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Patent code US11001563

Compile Data Set for Download or QSAR
Found 81 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497223
PNG
(US11001563, Compound WX126)
Show SMILES Cn1nc(nc1C(F)F)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C14H15F3N4O/c1-21-14(12(16)17)19-13(20-21)10-2-4-11(5-3-10)22-8-9(6-15)7-18/h2-6,12H,7-8,18H2,1H3/b9-6-
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TBA

US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497190
PNG
(US11001563, Compound WX085)
Show SMILES NC\C(COc1ccc(cc1)-c1nc(n[nH]1)C1CCC1)=C\F
Show InChI InChI=1S/C16H19FN4O/c17-8-11(9-18)10-22-14-6-4-13(5-7-14)16-19-15(20-21-16)12-2-1-3-12/h4-8,12H,1-3,9-10,18H2,(H,19,20,21)/b11-8-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497185
PNG
(US11001563, Compound WX079)
Show SMILES NC\C(COc1ccc(cc1)-c1nnc(NC2CC2)o1)=C\F
Show InChI InChI=1S/C15H17FN4O2/c16-7-10(8-17)9-21-13-5-1-11(2-6-13)14-19-20-15(22-14)18-12-3-4-12/h1-2,5-7,12H,3-4,8-9,17H2,(H,18,20)/b10-7-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497208
PNG
(US11001563, Compound WX103)
Show SMILES NC\C(COc1ccc(cc1)-c1nc(CC2CCCC2)n[nH]1)=C\F
Show InChI InChI=1S/C18H23FN4O/c19-10-14(11-20)12-24-16-7-5-15(6-8-16)18-21-17(22-23-18)9-13-3-1-2-4-13/h5-8,10,13H,1-4,9,11-12,20H2,(H,21,22,23)/b14-10-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497157
PNG
(US11001563, Compound WX024)
Show SMILES Cc1ncc(s1)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C14H15FN2OS/c1-10-17-8-14(19-10)12-2-4-13(5-3-12)18-9-11(6-15)7-16/h2-6,8H,7,9,16H2,1H3/b11-6-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497199
PNG
(US11001563, Compound WX094)
Show SMILES NC\C(COc1ccc(-c2nc(n[nH]2)C2CC2)c(F)c1)=C\F
Show InChI InChI=1S/C15H16F2N4O/c16-6-9(7-18)8-22-11-3-4-12(13(17)5-11)15-19-14(20-21-15)10-1-2-10/h3-6,10H,1-2,7-8,18H2,(H,19,20,21)/b9-6-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497155
PNG
(US11001563, Compound WX022)
Show SMILES Cc1csc(n1)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C14H15FN2OS/c1-10-9-19-14(17-10)12-2-4-13(5-3-12)18-8-11(6-15)7-16/h2-6,9H,7-8,16H2,1H3/b11-6-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497192
PNG
(US11001563, Compound WX087)
Show SMILES NC\C(COc1ccc(cc1)-c1nc(n[nH]1)C1(F)CC1)=C\F
Show InChI InChI=1S/C15H16F2N4O/c16-7-10(8-18)9-22-12-3-1-11(2-4-12)13-19-14(21-20-13)15(17)5-6-15/h1-4,7H,5-6,8-9,18H2,(H,19,20,21)/b10-7-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497161
PNG
(US11001563, Compound WX033)
Show SMILES NC\C(COc1ccc(cc1)-c1noc2ccccc12)=C\F
Show InChI InChI=1S/C17H15FN2O2/c18-9-12(10-19)11-21-14-7-5-13(6-8-14)17-15-3-1-2-4-16(15)22-20-17/h1-9H,10-11,19H2/b12-9-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497188
PNG
(US11001563, Compound WX082)
Show SMILES NC\C(COc1ccc(cc1)-c1nc(NC2CC2)no1)=C\F
Show InChI InChI=1S/C15H17FN4O2/c16-7-10(8-17)9-21-13-5-1-11(2-6-13)14-19-15(20-22-14)18-12-3-4-12/h1-2,5-7,12H,3-4,8-9,17H2,(H,18,20)/b10-7-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497172
PNG
(US11001563, Compound WX049)
Show SMILES NC\C(COc1ccc(cc1)-c1nnn(n1)C1CC1)=C\F
Show InChI InChI=1S/C14H16FN5O/c15-7-10(8-16)9-21-13-5-1-11(2-6-13)14-17-19-20(18-14)12-3-4-12/h1-2,5-7,12H,3-4,8-9,16H2/b10-7-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497209
PNG
(US11001563, Compound WX104)
Show SMILES Cn1nc(CC(F)(F)F)nc1-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C15H16F4N4O/c1-23-14(21-13(22-23)6-15(17,18)19)11-2-4-12(5-3-11)24-9-10(7-16)8-20/h2-5,7H,6,8-9,20H2,1H3/b10-7-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497198
PNG
(US11001563, Compound WX093)
Show SMILES NC\C(COc1ccc(cc1)-c1nc(n[nH]1)C1CCOCC1)=C\F
Show InChI InChI=1S/C17H21FN4O2/c18-9-12(10-19)11-24-15-3-1-13(2-4-15)16-20-17(22-21-16)14-5-7-23-8-6-14/h1-4,9,14H,5-8,10-11,19H2,(H,20,21,22)/b12-9-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497154
PNG
(US11001563, Compound WX021)
Show SMILES NC\C(COc1ccc(cc1)-c1ncccn1)=C\F
Show InChI InChI=1S/C14H14FN3O/c15-8-11(9-16)10-19-13-4-2-12(3-5-13)14-17-6-1-7-18-14/h1-8H,9-10,16H2/b11-8-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497159
PNG
(US11001563, Compound WX026)
Show SMILES Cn1ncc(n1)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C13H15FN4O/c1-18-16-8-13(17-18)11-2-4-12(5-3-11)19-9-10(6-14)7-15/h2-6,8H,7,9,15H2,1H3/b10-6-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497189
PNG
(US11001563, Compound WX083)
Show SMILES NC\C(COc1ccc(cc1)-c1nc(no1)C(CO)CCl)=C\F
Show InChI InChI=1S/C15H17ClFN3O3/c16-5-12(8-21)14-19-15(23-20-14)11-1-3-13(4-2-11)22-9-10(6-17)7-18/h1-4,6,12,21H,5,7-9,18H2/b10-6-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497206
PNG
(US11001563, Compound WX101)
Show SMILES NC\C(COc1ccc(-c2nc(CC(F)(F)F)n[nH]2)c(F)c1)=C\F
Show InChI InChI=1S/C14H13F5N4O/c15-5-8(6-20)7-24-9-1-2-10(11(16)3-9)13-21-12(22-23-13)4-14(17,18)19/h1-3,5H,4,6-7,20H2,(H,21,22,23)/b8-5-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497148
PNG
(US11001563, Compound WX008)
Show SMILES Cc1noc(n1)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C13H14FN3O2/c1-9-16-13(19-17-9)11-2-4-12(5-3-11)18-8-10(6-14)7-15/h2-6H,7-8,15H2,1H3/b10-6-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497207
PNG
(US11001563, Compound WX102)
Show SMILES Cc1[nH]c(sc1N1CCOCC1)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C18H23FN3O2S/c1-13-18(22-6-8-23-9-7-22)25-17(21-13)15-2-4-16(5-3-15)24-12-14(10-19)11-20/h2-5,10,21H,6-9,11-12,20H2,1H3/b14-10-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497156
PNG
(US11001563, Compound WX023)
Show SMILES NC\C(COc1ccc(cc1)-c1nc2ccccc2o1)=C\F
Show InChI InChI=1S/C17H15FN2O2/c18-9-12(10-19)11-21-14-7-5-13(6-8-14)17-20-15-3-1-2-4-16(15)22-17/h1-9H,10-11,19H2/b12-9-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497214
PNG
(US11001563, Compound WX111)
Show SMILES Cc1nc(sc1C)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C15H17FN2OS/c1-10-11(2)20-15(18-10)13-3-5-14(6-4-13)19-9-12(7-16)8-17/h3-7H,8-9,17H2,1-2H3/b12-7-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497193
PNG
(US11001563, Compound WX088)
Show SMILES NC\C(COc1ccc(cc1)-c1nc(n[nH]1)C(F)F)=C\F
Show InChI InChI=1S/C13H13F3N4O/c14-5-8(6-17)7-21-10-3-1-9(2-4-10)12-18-13(11(15)16)20-19-12/h1-5,11H,6-7,17H2,(H,18,19,20)/b8-5-
PDB
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497174
PNG
(US11001563, Compound WX054)
Show SMILES NC\C(COc1ccc(cc1)-c1nc2ccc(Cl)cc2[nH]1)=C\F
Show InChI InChI=1S/C17H15ClFN3O/c18-13-3-6-15-16(7-13)22-17(21-15)12-1-4-14(5-2-12)23-10-11(8-19)9-20/h1-8H,9-10,20H2,(H,21,22)/b11-8-
PDB
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497166
PNG
(US11001563, Compound WX040)
Show SMILES Cc1cnoc1-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C14H15FN2O2/c1-10-8-17-19-14(10)12-2-4-13(5-3-12)18-9-11(6-15)7-16/h2-6,8H,7,9,16H2,1H3/b11-6-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497169
PNG
(US11001563, Compound WX044)
Show SMILES NC\C(COc1ccc(cc1)-c1noc(n1)C1CC1)=C\F
Show InChI InChI=1S/C15H16FN3O2/c16-7-10(8-17)9-20-13-5-3-11(4-6-13)14-18-15(21-19-14)12-1-2-12/h3-7,12H,1-2,8-9,17H2/b10-7-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497165
PNG
(US11001563, Compound WX039)
Show SMILES Cc1coc(n1)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C14H15FN2O2/c1-10-8-19-14(17-10)12-2-4-13(5-3-12)18-9-11(6-15)7-16/h2-6,8H,7,9,16H2,1H3/b11-6-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497187
PNG
(US11001563, Compound WX081)
Show SMILES NC\C(COc1ccc(cc1)-c1nc(NC2CC2)n[nH]1)=C\F
Show InChI InChI=1S/C15H18FN5O/c16-7-10(8-17)9-22-13-5-1-11(2-6-13)14-19-15(21-20-14)18-12-3-4-12/h1-2,5-7,12H,3-4,8-9,17H2,(H2,18,19,20,21)/b10-7-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497210
PNG
(US11001563, Compound WX105)
Show SMILES Cn1nc(nc1CC(F)(F)F)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C15H16F4N4O/c1-23-13(6-15(17,18)19)21-14(22-23)11-2-4-12(5-3-11)24-9-10(7-16)8-20/h2-5,7H,6,8-9,20H2,1H3/b10-7-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497202
PNG
(US11001563, Compound WX097)
Show SMILES CCCc1n[nH]c(n1)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C15H19FN4O/c1-2-3-14-18-15(20-19-14)12-4-6-13(7-5-12)21-10-11(8-16)9-17/h4-8H,2-3,9-10,17H2,1H3,(H,18,19,20)/b11-8-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497167
PNG
(US11001563, Compound WX041)
Show SMILES Cc1cn[nH]c1-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C14H16FN3O/c1-10-8-17-18-14(10)12-2-4-13(5-3-12)19-9-11(6-15)7-16/h2-6,8H,7,9,16H2,1H3,(H,17,18)/b11-6-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497171
PNG
(US11001563, Compound WX048)
Show SMILES CC(C)(C)n1nnc(n1)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C15H20FN5O/c1-15(2,3)21-19-14(18-20-21)12-4-6-13(7-5-12)22-10-11(8-16)9-17/h4-8H,9-10,17H2,1-3H3/b11-8-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497160
PNG
(US11001563, Compound WX028)
Show SMILES Cc1nc(no1)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C13H14FN3O2/c1-9-16-13(17-19-9)11-2-4-12(5-3-11)18-8-10(6-14)7-15/h2-6H,7-8,15H2,1H3/b10-6-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497182
PNG
(US11001563, Compound WX075)
Show SMILES Cn1nc(nc1C1CC1)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C16H19FN4O/c1-21-16(13-2-3-13)19-15(20-21)12-4-6-14(7-5-12)22-10-11(8-17)9-18/h4-8,13H,2-3,9-10,18H2,1H3/b11-8-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497218
PNG
(US11001563, Compound WX118)
Show SMILES CCn1nc(nc1-c1ccc(OC\C(CN)=C/F)cc1)C1(F)CC1
Show InChI InChI=1S/C17H20F2N4O/c1-2-23-15(21-16(22-23)17(19)7-8-17)13-3-5-14(6-4-13)24-11-12(9-18)10-20/h3-6,9H,2,7-8,10-11,20H2,1H3/b12-9-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497217
PNG
(US11001563, Compound WX117)
Show SMILES Cn1nc(nc1-c1ccc(OC\C(CN)=C/F)cc1F)C1(F)CC1
Show InChI InChI=1S/C16H17F3N4O/c1-23-14(21-15(22-23)16(19)4-5-16)12-3-2-11(6-13(12)18)24-9-10(7-17)8-20/h2-3,6-7H,4-5,8-9,20H2,1H3/b10-7-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497179
PNG
(US11001563, Compound WX072)
Show SMILES NC\C(COc1ccc(cc1)-c1nc(n[nH]1)C(N)=O)=C\F
Show InChI InChI=1S/C13H14FN5O2/c14-5-8(6-15)7-21-10-3-1-9(2-4-10)12-17-13(11(16)20)19-18-12/h1-5H,6-7,15H2,(H2,16,20)(H,17,18,19)/b8-5-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497201
PNG
(US11001563, Compound WX096)
Show SMILES NC\C(COc1ccc(cc1)-c1nc(n[nH]1)C1CC1(F)F)=C\F
PDB
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497152
PNG
(US11001563, Compound WX017)
Show SMILES NC\C(COc1ccc(cc1)-c1nc(no1)-c1ccccc1)=C\F
Show InChI InChI=1S/C18H16FN3O2/c19-10-13(11-20)12-23-16-8-6-15(7-9-16)18-21-17(22-24-18)14-4-2-1-3-5-14/h1-10H,11-12,20H2/b13-10-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497162
PNG
(US11001563, Compound WX034)
Show SMILES NC\C(COc1ccc(cc1)-c1nc(n[nH]1)C1CC1)=C\F
Show InChI InChI=1S/C15H17FN4O/c16-7-10(8-17)9-21-13-5-3-12(4-6-13)15-18-14(19-20-15)11-1-2-11/h3-7,11H,1-2,8-9,17H2,(H,18,19,20)/b10-7-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497150
PNG
(US11001563, Compound WX014)
Show SMILES CCn1nnc(n1)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C13H16FN5O/c1-2-19-17-13(16-18-19)11-3-5-12(6-4-11)20-9-10(7-14)8-15/h3-7H,2,8-9,15H2,1H3/b10-7-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497177
PNG
(US11001563, Compound WX064)
Show SMILES NC\C(COc1ccc(cc1)-c1nnc(n1)C1CCCC1)=C\F
PDB
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497224
PNG
(US11001563, Compound WX127)
Show SMILES Cn1nc(nc1C1(F)CC1)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C16H18F2N4O/c1-22-15(16(18)6-7-16)20-14(21-22)12-2-4-13(5-3-12)23-10-11(8-17)9-19/h2-5,8H,6-7,9-10,19H2,1H3/b11-8-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497180
PNG
(US11001563, Compound WX073)
Show SMILES NC\C(COc1ccc(cc1)-c1nc(n[nH]1)N1CCOCC1)=C\F
Show InChI InChI=1S/C16H20FN5O2/c17-9-12(10-18)11-24-14-3-1-13(2-4-14)15-19-16(21-20-15)22-5-7-23-8-6-22/h1-4,9H,5-8,10-11,18H2,(H,19,20,21)/b12-9-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497158
PNG
(US11001563, Compound WX025)
Show SMILES Cn1cnc(n1)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C13H15FN4O/c1-18-9-16-13(17-18)11-2-4-12(5-3-11)19-8-10(6-14)7-15/h2-6,9H,7-8,15H2,1H3/b10-6-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497212
PNG
(US11001563, Compound WX107)
Show SMILES Cn1nc(nc1N1CCOCC1)-c1ccc(OC\C(CN)=C/F)cc1Cl
Show InChI InChI=1S/C17H21ClFN5O2/c1-23-17(24-4-6-25-7-5-24)21-16(22-23)14-3-2-13(8-15(14)18)26-11-12(9-19)10-20/h2-3,8-9H,4-7,10-11,20H2,1H3/b12-9-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497225
PNG
(US11001563, Compound WX128)
Show SMILES CCn1nc(nc1C(F)F)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C15H17F3N4O/c1-2-22-15(13(17)18)20-14(21-22)11-3-5-12(6-4-11)23-9-10(7-16)8-19/h3-7,13H,2,8-9,19H2,1H3/b10-7-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497181
PNG
(US11001563, Compound WX074)
Show SMILES NC\C(COc1ccc(cc1)-c1nc(N)n[nH]1)=C\F
Show InChI InChI=1S/C12H14FN5O/c13-5-8(6-14)7-19-10-3-1-9(2-4-10)11-16-12(15)18-17-11/h1-5H,6-7,14H2,(H3,15,16,17,18)/b8-5-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497151
PNG
(US11001563, Compound WX016)
Show SMILES NC\C(COc1ccc(cc1)-c1nc(no1)C1CC1)=C\F
Show InChI InChI=1S/C15H16FN3O2/c16-7-10(8-17)9-20-13-5-3-12(4-6-13)15-18-14(19-21-15)11-1-2-11/h3-7,11H,1-2,8-9,17H2/b10-7-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497219
PNG
(US11001563, Compound WX122)
Show SMILES Cn1nc(nc1N1CCOCC1)-c1ccc(OC\C(CN)=C/F)cc1F
Show InChI InChI=1S/C17H21F2N5O2/c1-23-17(24-4-6-25-7-5-24)21-16(22-23)14-3-2-13(8-15(14)19)26-11-12(9-18)10-20/h2-3,8-9H,4-7,10-11,20H2,1H3/b12-9-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497222
PNG
(US11001563, Compound WX125)
Show SMILES CCn1nc(nc1N1CCOCC1)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C18H24FN5O2/c1-2-24-18(23-7-9-25-10-8-23)21-17(22-24)15-3-5-16(6-4-15)26-13-14(11-19)12-20/h3-6,11H,2,7-10,12-13,20H2,1H3/b14-11-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497226
PNG
(US11001563, Compound WX129)
Show SMILES CCn1nc(nc1C1(F)CC1)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C17H20F2N4O/c1-2-23-16(17(19)7-8-17)21-15(22-23)13-3-5-14(6-4-13)24-11-12(9-18)10-20/h3-6,9H,2,7-8,10-11,20H2,1H3/b12-9-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497170
PNG
(US11001563, Compound WX045)
Show SMILES CC(C)(C)c1nc(no1)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C16H20FN3O2/c1-16(2,3)15-19-14(20-22-15)12-4-6-13(7-5-12)21-10-11(8-17)9-18/h4-8H,9-10,18H2,1-3H3/b11-8-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497211
PNG
(US11001563, Compound WX106)
Show SMILES CC1(C)CN=C(N1)c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C15H20FN3O/c1-15(2)10-18-14(19-15)12-3-5-13(6-4-12)20-9-11(7-16)8-17/h3-7H,8-10,17H2,1-2H3,(H,18,19)/b11-7-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497205
PNG
(US11001563, Compound WX100)
Show SMILES NC\C(COc1ccc(-c2nc(n[nH]2)N2CCOCC2)c(F)c1)=C\F
Show InChI InChI=1S/C16H19F2N5O2/c17-8-11(9-19)10-25-12-1-2-13(14(18)7-12)15-20-16(22-21-15)23-3-5-24-6-4-23/h1-2,7-8H,3-6,9-10,19H2,(H,20,21,22)/b11-8-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497195
PNG
(US11001563, Compound WX090)
Show SMILES Cn1nc(nc1C(C)(C)C)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C17H23FN4O/c1-17(2,3)16-20-15(21-22(16)4)13-5-7-14(8-6-13)23-11-12(9-18)10-19/h5-9H,10-11,19H2,1-4H3/b12-9-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497216
PNG
(US11001563, Compound WX113)
Show SMILES NC\C(COc1ccc(cc1)-c1nc(C2CC2)n(CC(F)(F)F)n1)=C\F
Show InChI InChI=1S/C17H18F4N4O/c18-7-11(8-22)9-26-14-5-3-12(4-6-14)15-23-16(13-1-2-13)25(24-15)10-17(19,20)21/h3-7,13H,1-2,8-10,22H2/b11-7-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497178
PNG
(US11001563, Compound WX070)
Show SMILES NC\C(COc1ccc(cc1)-c1nccc(n1)N1CCOCC1)=C\F
Show InChI InChI=1S/C18H21FN4O2/c19-11-14(12-20)13-25-16-3-1-15(2-4-16)18-21-6-5-17(22-18)23-7-9-24-10-8-23/h1-6,11H,7-10,12-13,20H2/b14-11-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497196
PNG
(US11001563, Compound WX091)
Show SMILES CC(C)n1nc(nc1C1CC1)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C18H23FN4O/c1-12(2)23-18(15-3-4-15)21-17(22-23)14-5-7-16(8-6-14)24-11-13(9-19)10-20/h5-9,12,15H,3-4,10-11,20H2,1-2H3/b13-9-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497176
PNG
(US11001563, Compound WX062)
Show SMILES CS(=O)(=O)n1nc(nc1-c1ccc(OC\C(CN)=C/F)cc1)C1CC1
Show InChI InChI=1S/C16H19FN4O3S/c1-25(22,23)21-16(19-15(20-21)12-2-3-12)13-4-6-14(7-5-13)24-10-11(8-17)9-18/h4-8,12H,2-3,9-10,18H2,1H3/b11-8-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497173
PNG
(US11001563, Compound WX052)
Show SMILES NC\C(COc1ccc(cc1)N1C(=O)C(=O)c2ccccc12)=C\F
Show InChI InChI=1S/C18H15FN2O3/c19-9-12(10-20)11-24-14-7-5-13(6-8-14)21-16-4-2-1-3-15(16)17(22)18(21)23/h1-9H,10-11,20H2/b12-9-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497227
PNG
(US11001563, Compound WX130)
Show SMILES CC(C)n1nc(nc1C1(F)CC1)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C18H22F2N4O/c1-12(2)24-17(18(20)7-8-18)22-16(23-24)14-3-5-15(6-4-14)25-11-13(9-19)10-21/h3-6,9,12H,7-8,10-11,21H2,1-2H3/b13-9-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497197
PNG
(US11001563, Compound WX092)
Show SMILES CCn1nc(nc1C1CC1)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C17H21FN4O/c1-2-22-17(14-3-4-14)20-16(21-22)13-5-7-15(8-6-13)23-11-12(9-18)10-19/h5-9,14H,2-4,10-11,19H2,1H3/b12-9-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497221
PNG
(US11001563, Compound WX124)
Show SMILES CC(C)n1nc(nc1C(F)F)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C16H19F3N4O/c1-10(2)23-16(14(18)19)21-15(22-23)12-3-5-13(6-4-12)24-9-11(7-17)8-20/h3-7,10,14H,8-9,20H2,1-2H3/b11-7-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497168
PNG
(US11001563, Compound WX042)
Show SMILES CC(C)(C)NC(=O)c1noc(n1)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C17H21FN4O3/c1-17(2,3)21-15(23)14-20-16(25-22-14)12-4-6-13(7-5-12)24-10-11(8-18)9-19/h4-8H,9-10,19H2,1-3H3,(H,21,23)/b11-8-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497184
PNG
(US11001563, Compound WX077)
Show SMILES CC(C)(C)C(=O)Nc1noc(n1)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C17H21FN4O3/c1-17(2,3)15(23)21-16-20-14(25-22-16)12-4-6-13(7-5-12)24-10-11(8-18)9-19/h4-8H,9-10,19H2,1-3H3,(H,21,22,23)/b11-8-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497175
PNG
(US11001563, Compound WX056)
Show SMILES NC\C(COc1ccc(-c2nc(no2)C2CC2)c(Cl)c1)=C\F
Show InChI InChI=1S/C15H15ClFN3O2/c16-13-5-11(21-8-9(6-17)7-18)3-4-12(13)15-19-14(20-22-15)10-1-2-10/h3-6,10H,1-2,7-8,18H2/b9-6-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497215
PNG
(US11001563, Compound WX112)
Show SMILES NC\C(COc1ccc(cc1)-c1nc(C2CC2)n(CCO)n1)=C\F
Show InChI InChI=1S/C17H21FN4O2/c18-9-12(10-19)11-24-15-5-3-13(4-6-15)16-20-17(14-1-2-14)22(21-16)7-8-23/h3-6,9,14,23H,1-2,7-8,10-11,19H2/b12-9-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497203
PNG
(US11001563, Compound WX098)
Show SMILES Cn1nc(nc1-c1ccc(OC\C(CN)=C/F)cc1F)C1CC1
Show InChI InChI=1S/C16H18F2N4O/c1-22-16(20-15(21-22)11-2-3-11)13-5-4-12(6-14(13)18)23-9-10(7-17)8-19/h4-7,11H,2-3,8-9,19H2,1H3/b10-7-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497194
PNG
(US11001563, Compound WX089)
Show SMILES Cn1nc(nc1-c1ccc(OC\C(CN)=C/F)cc1)C(C)(C)C
Show InChI InChI=1S/C17H23FN4O/c1-17(2,3)16-20-15(22(4)21-16)13-5-7-14(8-6-13)23-11-12(9-18)10-19/h5-9H,10-11,19H2,1-4H3/b12-9-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497153
PNG
(US11001563, Compound WX019)
Show SMILES CC(C)(C)c1noc(n1)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C16H20FN3O2/c1-16(2,3)15-19-14(22-20-15)12-4-6-13(7-5-12)21-10-11(8-17)9-18/h4-8H,9-10,18H2,1-3H3/b11-8-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497183
PNG
(US11001563, Compound WX076)
Show SMILES Cn1nc(nc1-c1ccc(OC\C(CN)=C/F)cc1)C1CC1
Show InChI InChI=1S/C16H19FN4O/c1-21-16(19-15(20-21)12-2-3-12)13-4-6-14(7-5-13)22-10-11(8-17)9-18/h4-8,12H,2-3,9-10,18H2,1H3/b11-8-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497220
PNG
(US11001563, Compound WX123)
Show SMILES CC(C)n1nc(nc1N1CCOCC1)-c1ccc(OC\C(CN)=C/F)cc1F
Show InChI InChI=1S/C19H25F2N5O2/c1-13(2)26-19(25-5-7-27-8-6-25)23-18(24-26)16-4-3-15(9-17(16)21)28-12-14(10-20)11-22/h3-4,9-10,13H,5-8,11-12,22H2,1-2H3/b14-10-
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n/an/a 2.20n/an/an/an/an/an/a



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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497163
PNG
(US11001563, Compound WX035)
Show SMILES CC(C)(C)c1n[nH]c(n1)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C16H21FN4O/c1-16(2,3)15-19-14(20-21-15)12-4-6-13(7-5-12)22-10-11(8-17)9-18/h4-8H,9-10,18H2,1-3H3,(H,19,20,21)/b11-8-
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n/an/a 2.30n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497146
PNG
(US11001563, Compound WX004)
Show SMILES Cc1nnc(o1)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C13H14FN3O2/c1-9-16-17-13(19-9)11-2-4-12(5-3-11)18-8-10(6-14)7-15/h2-6H,7-8,15H2,1H3/b10-6-
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n/an/a 2.5n/an/an/an/an/an/a



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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497213
PNG
(US11001563, Compound WX109)
Show SMILES CC(C)n1nc(nc1-c1ccc(OC\C(CN)=C/F)cc1)C(F)F
Show InChI InChI=1S/C16H19F3N4O/c1-10(2)23-16(21-15(22-23)14(18)19)12-3-5-13(6-4-12)24-9-11(7-17)8-20/h3-7,10,14H,8-9,20H2,1-2H3/b11-7-
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n/an/a 2.80n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497200
PNG
(US11001563, Compound WX095)
Show SMILES Cn1nc(nc1C1CCOCC1)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C18H23FN4O2/c1-23-18(15-6-8-24-9-7-15)21-17(22-23)14-2-4-16(5-3-14)25-12-13(10-19)11-20/h2-5,10,15H,6-9,11-12,20H2,1H3/b13-10-
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n/an/a 2.90n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497204
PNG
(US11001563, Compound WX099)
Show SMILES NC\C(COc1cc(F)c(-c2nc(n[nH]2)N2CCOCC2)c(F)c1)=C\F
Show InChI InChI=1S/C16H18F3N5O2/c17-7-10(8-20)9-26-11-5-12(18)14(13(19)6-11)15-21-16(23-22-15)24-1-3-25-4-2-24/h5-7H,1-4,8-9,20H2,(H,21,22,23)/b10-7-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497149
PNG
(US11001563, Compound WX009)
Show SMILES Cc1n[nH]c(n1)-c1ccc(OC\C(CN)=C/F)cc1
Show InChI InChI=1S/C13H15FN4O/c1-9-16-13(18-17-9)11-2-4-12(5-3-11)19-8-10(6-14)7-15/h2-6H,7-8,15H2,1H3,(H,16,17,18)/b10-6-
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US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497186
PNG
(US11001563, Compound WX080)
Show SMILES COc1ccc(Cn2nc(nc2NC2CC2)-c2ccc(OC\C(CN)=C/F)cc2)cc1
Show InChI InChI=1S/C23H26FN5O2/c1-30-20-8-2-16(3-9-20)14-29-23(26-19-6-7-19)27-22(28-29)18-4-10-21(11-5-18)31-15-17(12-24)13-25/h2-5,8-12,19H,6-7,13-15,25H2,1H3,(H,26,27,28)/b17-12-
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n/an/a 3.80n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497164
PNG
(US11001563, Compound WX036)
Show SMILES NC\C(COc1ccc(cc1)-c1nc(n[nH]1)C(F)(F)F)=C\F
Show InChI InChI=1S/C13H12F4N4O/c14-5-8(6-18)7-22-10-3-1-9(2-4-10)11-19-12(21-20-11)13(15,16)17/h1-5H,6-7,18H2,(H,19,20,21)/b8-5-
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n/an/a 4.60n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Homo sapiens (Human))
BDBM497191
PNG
(US11001563, Compound WX086)
Show SMILES NC\C(COc1ccc(cc1)-c1nc(cs1)N1CCOCC1)=C\F
Show InChI InChI=1S/C17H20FN3O2S/c18-9-13(10-19)11-23-15-3-1-14(2-4-15)17-20-16(12-24-17)21-5-7-22-8-6-21/h1-4,9,12H,5-8,10-11,19H2/b13-9-
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n/an/a 9.90n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The inhibition of the sample on VAP-enzyme activity was measured by using an Amplex® Red Monoamine Oxidase kit (Invitrogen #A12214). 100 nL of the gr...


US Patent US11001563 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%