BindingDB logo
myBDB logout

Patent code US11001572

Compile Data Set for Download or QSAR
Found 40 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM443226
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCC(CC3)N(C)C)ncn2)c1Cl
Show InChI InChI=1S/C30H36Cl2N8O4/c1-7-26(41)36-21-14-19(40-12-10-18(11-13-40)38(2)3)8-9-20(21)35-24-16-25(34-17-33-24)39(4)30(42)37-29-27(31)22(43-5)15-23(44-6)28(29)32/h7-9,14-18H,1,10-13H2,2-6H3,(H,36,41)(H,37,42)(H,33,34,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM443223
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES CCN1CCC2(CN(C2)c2ccc(Nc3cc(ncn3)N(C)C(=O)Nc3c(Cl)c(OC)cc(OC)c3Cl)c(NC(=O)C=C)c2)CC1
Show InChI InChI=1S/C32H38Cl2N8O4/c1-6-27(43)38-22-14-20(42-17-32(18-42)10-12-41(7-2)13-11-32)8-9-21(22)37-25-16-26(36-19-35-25)40(3)31(44)39-30-28(33)23(45-4)15-24(46-5)29(30)34/h6,8-9,14-16,19H,1,7,10-13,17-18H2,2-5H3,(H,38,43)(H,39,44)(H,35,36,37)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.30n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM443222
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCC4(C3)CCNCC4)ncn2)c1Cl
Show InChI InChI=1S/C31H36Cl2N8O4/c1-5-26(42)38-21-14-19(41-13-10-31(17-41)8-11-34-12-9-31)6-7-20(21)37-24-16-25(36-18-35-24)40(2)30(43)39-29-27(32)22(44-3)15-23(45-4)28(29)33/h5-7,14-16,18,34H,1,8-13,17H2,2-4H3,(H,38,42)(H,39,43)(H,35,36,37)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM443225
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES CCN1CCC2(CCN(C2)c2ccc(Nc3cc(ncn3)N(C)C(=O)Nc3c(Cl)c(OC)cc(OC)c3Cl)c(NC(=O)C=C)c2)C1
Show InChI InChI=1S/C32H38Cl2N8O4/c1-6-27(43)38-22-14-20(42-13-11-32(18-42)10-12-41(7-2)17-32)8-9-21(22)37-25-16-26(36-19-35-25)40(3)31(44)39-30-28(33)23(45-4)15-24(46-5)29(30)34/h6,8-9,14-16,19H,1,7,10-13,17-18H2,2-5H3,(H,38,43)(H,39,44)(H,35,36,37)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.20n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM443224
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES CCN1CCN(CC11CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C31H36Cl2N8O4/c1-6-26(42)37-21-14-19(40-12-13-41(7-2)31(17-40)10-11-31)8-9-20(21)36-24-16-25(35-18-34-24)39(3)30(43)38-29-27(32)22(44-4)15-23(45-5)28(29)33/h6,8-9,14-16,18H,1,7,10-13,17H2,2-5H3,(H,37,42)(H,38,43)(H,34,35,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.40n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM443227
PNG
(N-(5-(4-Cyclopropylpiperazin-1-yl)-2-((6-(3-(2,6-d...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CC3)C3CC3)ncn2)c1Cl
Show InChI InChI=1S/C30H34Cl2N8O4/c1-5-26(41)36-21-14-19(40-12-10-39(11-13-40)18-6-7-18)8-9-20(21)35-24-16-25(34-17-33-24)38(2)30(42)37-29-27(31)22(43-3)15-23(44-4)28(29)32/h5,8-9,14-18H,1,6-7,10-13H2,2-4H3,(H,36,41)(H,37,42)(H,33,34,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.5n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM443228
PNG
(N-(5-(4-(Cyclopropyl(methyl)amino)piperidin-1-yl)-...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCC(CC3)N(C)C3CC3)ncn2)c1Cl
Show InChI InChI=1S/C32H38Cl2N8O4/c1-6-28(43)38-23-15-21(42-13-11-20(12-14-42)40(2)19-7-8-19)9-10-22(23)37-26-17-27(36-18-35-26)41(3)32(44)39-31-29(33)24(45-4)16-25(46-5)30(31)34/h6,9-10,15-20H,1,7-8,11-14H2,2-5H3,(H,38,43)(H,39,44)(H,35,36,37)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.80n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM443221
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCNC4(CC4)C3)ncn2)c1Cl
Show InChI InChI=1S/C29H32Cl2N8O4/c1-5-24(40)36-19-12-17(39-11-10-34-29(15-39)8-9-29)6-7-18(19)35-22-14-23(33-16-32-22)38(2)28(41)37-27-25(30)20(42-3)13-21(43-4)26(27)31/h5-7,12-14,16,34H,1,8-11,15H2,2-4H3,(H,36,40)(H,37,41)(H,32,33,35)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.60n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM443220
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CC4(C3)CCNCC4)ncn2)c1Cl
Show InChI InChI=1S/C30H34Cl2N8O4/c1-5-25(41)37-20-12-18(40-15-30(16-40)8-10-33-11-9-30)6-7-19(20)36-23-14-24(35-17-34-23)39(2)29(42)38-28-26(31)21(43-3)13-22(44-4)27(28)32/h5-7,12-14,17,33H,1,8-11,15-16H2,2-4H3,(H,37,41)(H,38,42)(H,34,35,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM249396
PNG
(US10537571, Compound 108 | US10562888, Compound 10...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
Purchase

PC cid
PC sid
UniChem
US Patent
n/an/a 14n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM443221
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCNC4(CC4)C3)ncn2)c1Cl
Show InChI InChI=1S/C29H32Cl2N8O4/c1-5-24(40)36-19-12-17(39-11-10-34-29(15-39)8-9-29)6-7-18(19)35-22-14-23(33-16-32-22)38(2)28(41)37-27-25(30)20(42-3)13-21(43-4)26(27)31/h5-7,12-14,16,34H,1,8-11,15H2,2-4H3,(H,36,40)(H,37,41)(H,32,33,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 87n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM443220
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CC4(C3)CCNCC4)ncn2)c1Cl
Show InChI InChI=1S/C30H34Cl2N8O4/c1-5-25(41)37-20-12-18(40-15-30(16-40)8-10-33-11-9-30)6-7-19(20)36-23-14-24(35-17-34-23)39(2)29(42)38-28-26(31)21(43-3)13-22(44-4)27(28)32/h5-7,12-14,17,33H,1,8-11,15-16H2,2-4H3,(H,37,41)(H,38,42)(H,34,35,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 160n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM443223
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES CCN1CCC2(CN(C2)c2ccc(Nc3cc(ncn3)N(C)C(=O)Nc3c(Cl)c(OC)cc(OC)c3Cl)c(NC(=O)C=C)c2)CC1
Show InChI InChI=1S/C32H38Cl2N8O4/c1-6-27(43)38-22-14-20(42-17-32(18-42)10-12-41(7-2)13-11-32)8-9-21(22)37-25-16-26(36-19-35-25)40(3)31(44)39-30-28(33)23(45-4)15-24(46-5)29(30)34/h6,8-9,14-16,19H,1,7,10-13,17-18H2,2-5H3,(H,38,43)(H,39,44)(H,35,36,37)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 165n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM443226
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCC(CC3)N(C)C)ncn2)c1Cl
Show InChI InChI=1S/C30H36Cl2N8O4/c1-7-26(41)36-21-14-19(40-12-10-18(11-13-40)38(2)3)8-9-20(21)35-24-16-25(34-17-33-24)39(4)30(42)37-29-27(31)22(43-5)15-23(44-6)28(29)32/h7-9,14-18H,1,10-13H2,2-6H3,(H,36,41)(H,37,42)(H,33,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 176n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM443221
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCNC4(CC4)C3)ncn2)c1Cl
Show InChI InChI=1S/C29H32Cl2N8O4/c1-5-24(40)36-19-12-17(39-11-10-34-29(15-39)8-9-29)6-7-18(19)35-22-14-23(33-16-32-22)38(2)28(41)37-27-25(30)20(42-3)13-21(43-4)26(27)31/h5-7,12-14,16,34H,1,8-11,15H2,2-4H3,(H,36,40)(H,37,41)(H,32,33,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 179n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM443221
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCNC4(CC4)C3)ncn2)c1Cl
Show InChI InChI=1S/C29H32Cl2N8O4/c1-5-24(40)36-19-12-17(39-11-10-34-29(15-39)8-9-29)6-7-18(19)35-22-14-23(33-16-32-22)38(2)28(41)37-27-25(30)20(42-3)13-21(43-4)26(27)31/h5-7,12-14,16,34H,1,8-11,15H2,2-4H3,(H,36,40)(H,37,41)(H,32,33,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 189n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM249396
PNG
(US10537571, Compound 108 | US10562888, Compound 10...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
Purchase

PC cid
PC sid
UniChem
US Patent
n/an/a 210n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM443228
PNG
(N-(5-(4-(Cyclopropyl(methyl)amino)piperidin-1-yl)-...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCC(CC3)N(C)C3CC3)ncn2)c1Cl
Show InChI InChI=1S/C32H38Cl2N8O4/c1-6-28(43)38-23-15-21(42-13-11-20(12-14-42)40(2)19-7-8-19)9-10-22(23)37-26-17-27(36-18-35-26)41(3)32(44)39-31-29(33)24(45-4)16-25(46-5)30(31)34/h6,9-10,15-20H,1,7-8,11-14H2,2-5H3,(H,38,43)(H,39,44)(H,35,36,37)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 228n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM443228
PNG
(N-(5-(4-(Cyclopropyl(methyl)amino)piperidin-1-yl)-...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCC(CC3)N(C)C3CC3)ncn2)c1Cl
Show InChI InChI=1S/C32H38Cl2N8O4/c1-6-28(43)38-23-15-21(42-13-11-20(12-14-42)40(2)19-7-8-19)9-10-22(23)37-26-17-27(36-18-35-26)41(3)32(44)39-31-29(33)24(45-4)16-25(46-5)30(31)34/h6,9-10,15-20H,1,7-8,11-14H2,2-5H3,(H,38,43)(H,39,44)(H,35,36,37)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 244n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM443228
PNG
(N-(5-(4-(Cyclopropyl(methyl)amino)piperidin-1-yl)-...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCC(CC3)N(C)C3CC3)ncn2)c1Cl
Show InChI InChI=1S/C32H38Cl2N8O4/c1-6-28(43)38-23-15-21(42-13-11-20(12-14-42)40(2)19-7-8-19)9-10-22(23)37-26-17-27(36-18-35-26)41(3)32(44)39-31-29(33)24(45-4)16-25(46-5)30(31)34/h6,9-10,15-20H,1,7-8,11-14H2,2-5H3,(H,38,43)(H,39,44)(H,35,36,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 311n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM443225
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES CCN1CCC2(CCN(C2)c2ccc(Nc3cc(ncn3)N(C)C(=O)Nc3c(Cl)c(OC)cc(OC)c3Cl)c(NC(=O)C=C)c2)C1
Show InChI InChI=1S/C32H38Cl2N8O4/c1-6-27(43)38-22-14-20(42-13-11-32(18-42)10-12-41(7-2)17-32)8-9-21(22)37-25-16-26(36-19-35-25)40(3)31(44)39-30-28(33)23(45-4)15-24(46-5)29(30)34/h6,8-9,14-16,19H,1,7,10-13,17-18H2,2-5H3,(H,38,43)(H,39,44)(H,35,36,37)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 368n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM443223
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES CCN1CCC2(CN(C2)c2ccc(Nc3cc(ncn3)N(C)C(=O)Nc3c(Cl)c(OC)cc(OC)c3Cl)c(NC(=O)C=C)c2)CC1
Show InChI InChI=1S/C32H38Cl2N8O4/c1-6-27(43)38-22-14-20(42-17-32(18-42)10-12-41(7-2)13-11-32)8-9-21(22)37-25-16-26(36-19-35-25)40(3)31(44)39-30-28(33)23(45-4)15-24(46-5)29(30)34/h6,8-9,14-16,19H,1,7,10-13,17-18H2,2-5H3,(H,38,43)(H,39,44)(H,35,36,37)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 382n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM443226
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCC(CC3)N(C)C)ncn2)c1Cl
Show InChI InChI=1S/C30H36Cl2N8O4/c1-7-26(41)36-21-14-19(40-12-10-18(11-13-40)38(2)3)8-9-20(21)35-24-16-25(34-17-33-24)39(4)30(42)37-29-27(31)22(43-5)15-23(44-6)28(29)32/h7-9,14-18H,1,10-13H2,2-6H3,(H,36,41)(H,37,42)(H,33,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 405n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM443223
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES CCN1CCC2(CN(C2)c2ccc(Nc3cc(ncn3)N(C)C(=O)Nc3c(Cl)c(OC)cc(OC)c3Cl)c(NC(=O)C=C)c2)CC1
Show InChI InChI=1S/C32H38Cl2N8O4/c1-6-27(43)38-22-14-20(42-17-32(18-42)10-12-41(7-2)13-11-32)8-9-21(22)37-25-16-26(36-19-35-25)40(3)31(44)39-30-28(33)23(45-4)15-24(46-5)29(30)34/h6,8-9,14-16,19H,1,7,10-13,17-18H2,2-5H3,(H,38,43)(H,39,44)(H,35,36,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 439n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM443222
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCC4(C3)CCNCC4)ncn2)c1Cl
Show InChI InChI=1S/C31H36Cl2N8O4/c1-5-26(42)38-21-14-19(41-13-10-31(17-41)8-11-34-12-9-31)6-7-20(21)37-24-16-25(36-18-35-24)40(2)30(43)39-29-27(32)22(44-3)15-23(45-4)28(29)33/h5-7,14-16,18,34H,1,8-13,17H2,2-4H3,(H,38,42)(H,39,43)(H,35,36,37)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 465n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM443224
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES CCN1CCN(CC11CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C31H36Cl2N8O4/c1-6-26(42)37-21-14-19(40-12-13-41(7-2)31(17-40)10-11-31)8-9-20(21)36-24-16-25(35-18-34-24)39(3)30(43)38-29-27(32)22(44-4)15-23(45-5)28(29)33/h6,8-9,14-16,18H,1,7,10-13,17H2,2-5H3,(H,37,42)(H,38,43)(H,34,35,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 533n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM443225
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES CCN1CCC2(CCN(C2)c2ccc(Nc3cc(ncn3)N(C)C(=O)Nc3c(Cl)c(OC)cc(OC)c3Cl)c(NC(=O)C=C)c2)C1
Show InChI InChI=1S/C32H38Cl2N8O4/c1-6-27(43)38-22-14-20(42-13-11-32(18-42)10-12-41(7-2)17-32)8-9-21(22)37-25-16-26(36-19-35-25)40(3)31(44)39-30-28(33)23(45-4)15-24(46-5)29(30)34/h6,8-9,14-16,19H,1,7,10-13,17-18H2,2-5H3,(H,38,43)(H,39,44)(H,35,36,37)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 544n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM443220
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CC4(C3)CCNCC4)ncn2)c1Cl
Show InChI InChI=1S/C30H34Cl2N8O4/c1-5-25(41)37-20-12-18(40-15-30(16-40)8-10-33-11-9-30)6-7-19(20)36-23-14-24(35-17-34-23)39(2)29(42)38-28-26(31)21(43-3)13-22(44-4)27(28)32/h5-7,12-14,17,33H,1,8-11,15-16H2,2-4H3,(H,37,41)(H,38,42)(H,34,35,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 557n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM249396
PNG
(US10537571, Compound 108 | US10562888, Compound 10...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
Purchase

PC cid
PC sid
UniChem
US Patent
n/an/a 575n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM249396
PNG
(US10537571, Compound 108 | US10562888, Compound 10...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
Purchase

PC cid
PC sid
UniChem
US Patent
n/an/a 579n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM443227
PNG
(N-(5-(4-Cyclopropylpiperazin-1-yl)-2-((6-(3-(2,6-d...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CC3)C3CC3)ncn2)c1Cl
Show InChI InChI=1S/C30H34Cl2N8O4/c1-5-26(41)36-21-14-19(40-12-10-39(11-13-40)18-6-7-18)8-9-20(21)35-24-16-25(34-17-33-24)38(2)30(42)37-29-27(31)22(43-3)15-23(44-4)28(29)32/h5,8-9,14-18H,1,6-7,10-13H2,2-4H3,(H,36,41)(H,37,42)(H,33,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 618n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM443224
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES CCN1CCN(CC11CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C31H36Cl2N8O4/c1-6-26(42)37-21-14-19(40-12-13-41(7-2)31(17-40)10-11-31)8-9-20(21)36-24-16-25(35-18-34-24)39(3)30(43)38-29-27(32)22(44-4)15-23(45-5)28(29)33/h6,8-9,14-16,18H,1,7,10-13,17H2,2-5H3,(H,37,42)(H,38,43)(H,34,35,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 624n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM443227
PNG
(N-(5-(4-Cyclopropylpiperazin-1-yl)-2-((6-(3-(2,6-d...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CC3)C3CC3)ncn2)c1Cl
Show InChI InChI=1S/C30H34Cl2N8O4/c1-5-26(41)36-21-14-19(40-12-10-39(11-13-40)18-6-7-18)8-9-20(21)35-24-16-25(34-17-33-24)38(2)30(42)37-29-27(31)22(43-3)15-23(44-4)28(29)32/h5,8-9,14-18H,1,6-7,10-13H2,2-4H3,(H,36,41)(H,37,42)(H,33,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 644n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM443222
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCC4(C3)CCNCC4)ncn2)c1Cl
Show InChI InChI=1S/C31H36Cl2N8O4/c1-5-26(42)38-21-14-19(41-13-10-31(17-41)8-11-34-12-9-31)6-7-20(21)37-24-16-25(36-18-35-24)40(2)30(43)39-29-27(32)22(44-3)15-23(45-4)28(29)33/h5-7,14-16,18,34H,1,8-13,17H2,2-4H3,(H,38,42)(H,39,43)(H,35,36,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 715n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM443226
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCC(CC3)N(C)C)ncn2)c1Cl
Show InChI InChI=1S/C30H36Cl2N8O4/c1-7-26(41)36-21-14-19(40-12-10-18(11-13-40)38(2)3)8-9-20(21)35-24-16-25(34-17-33-24)39(4)30(42)37-29-27(31)22(43-5)15-23(44-6)28(29)32/h7-9,14-18H,1,10-13H2,2-6H3,(H,36,41)(H,37,42)(H,33,34,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 729n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM443225
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES CCN1CCC2(CCN(C2)c2ccc(Nc3cc(ncn3)N(C)C(=O)Nc3c(Cl)c(OC)cc(OC)c3Cl)c(NC(=O)C=C)c2)C1
Show InChI InChI=1S/C32H38Cl2N8O4/c1-6-27(43)38-22-14-20(42-13-11-32(18-42)10-12-41(7-2)17-32)8-9-21(22)37-25-16-26(36-19-35-25)40(3)31(44)39-30-28(33)23(45-4)15-24(46-5)29(30)34/h6,8-9,14-16,19H,1,7,10-13,17-18H2,2-5H3,(H,38,43)(H,39,44)(H,35,36,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 731n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM443220
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CC4(C3)CCNCC4)ncn2)c1Cl
Show InChI InChI=1S/C30H34Cl2N8O4/c1-5-25(41)37-20-12-18(40-15-30(16-40)8-10-33-11-9-30)6-7-19(20)36-23-14-24(35-17-34-23)39(2)29(42)38-28-26(31)21(43-3)13-22(44-4)27(28)32/h5-7,12-14,17,33H,1,8-11,15-16H2,2-4H3,(H,37,41)(H,38,42)(H,34,35,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 777n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM443227
PNG
(N-(5-(4-Cyclopropylpiperazin-1-yl)-2-((6-(3-(2,6-d...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CC3)C3CC3)ncn2)c1Cl
Show InChI InChI=1S/C30H34Cl2N8O4/c1-5-26(41)36-21-14-19(40-12-10-39(11-13-40)18-6-7-18)8-9-20(21)35-24-16-25(34-17-33-24)38(2)30(42)37-29-27(31)22(43-3)15-23(44-4)28(29)32/h5,8-9,14-18H,1,6-7,10-13H2,2-4H3,(H,36,41)(H,37,42)(H,33,34,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 880n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM443224
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES CCN1CCN(CC11CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1
Show InChI InChI=1S/C31H36Cl2N8O4/c1-6-26(42)37-21-14-19(40-12-13-41(7-2)31(17-40)10-11-31)8-9-20(21)36-24-16-25(35-18-34-24)39(3)30(43)38-29-27(32)22(44-4)15-23(45-5)28(29)33/h6,8-9,14-16,18H,1,7,10-13,17H2,2-5H3,(H,37,42)(H,38,43)(H,34,35,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 989n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM443222
PNG
(N-(2-((6-(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-m...)
Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCC4(C3)CCNCC4)ncn2)c1Cl
Show InChI InChI=1S/C31H36Cl2N8O4/c1-5-26(42)38-21-14-19(41-13-10-31(17-41)8-11-34-12-9-31)6-7-20(21)37-24-16-25(36-18-35-24)40(2)30(43)39-29-27(32)22(44-3)15-23(45-4)28(29)33/h5-7,14-16,18,34H,1,8-13,17H2,2-4H3,(H,38,42)(H,39,43)(H,35,36,37)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.43E+3n/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following method was used to determine the inhibition degree of the kinase activity of recombinant human FGFR protein by the compounds of the pre...


US Patent US11001572 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%