BindingDB logo
myBDB logout

Patent code US11001586

Compile Data Set for Download or QSAR
Found 178 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497247
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CCCCN1
Show InChI InChI=1S/C28H44N6O2/c1-3-6-19(2)31-28-30-17-23-24(18-34(26(23)32-28)21-8-10-22(35)11-9-21)20-12-15-33(16-13-20)27(36)25-7-4-5-14-29-25/h17-22,25,29,35H,3-16H2,1-2H3,(H,30,31,32)/t19-,21-,22-,25?/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497260
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccncc1
Show InChI InChI=1S/C28H38N6O2/c1-3-4-19(2)31-28-30-17-24-25(18-34(26(24)32-28)22-5-7-23(35)8-6-22)20-11-15-33(16-12-20)27(36)21-9-13-29-14-10-21/h9-10,13-14,17-20,22-23,35H,3-8,11-12,15-16H2,1-2H3,(H,30,31,32)/t19-,22-,23-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497263
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C29H39N5O2/c1-3-7-20(2)31-29-30-18-25-26(19-34(27(25)32-29)23-10-12-24(35)13-11-23)21-14-16-33(17-15-21)28(36)22-8-5-4-6-9-22/h4-6,8-9,18-21,23-24,35H,3,7,10-17H2,1-2H3,(H,30,31,32)/t20-,23-,24-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497265
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cccc(OC)c1
Show InChI InChI=1S/C30H41N5O3/c1-4-6-20(2)32-30-31-18-26-27(19-35(28(26)33-30)23-9-11-24(36)12-10-23)21-13-15-34(16-14-21)29(37)22-7-5-8-25(17-22)38-3/h5,7-8,17-21,23-24,36H,4,6,9-16H2,1-3H3,(H,31,32,33)/t20-,23-,24-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497268
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccnc(C)c1
Show InChI InChI=1S/C29H40N6O2/c1-4-5-19(2)32-29-31-17-25-26(18-35(27(25)33-29)23-6-8-24(36)9-7-23)21-11-14-34(15-12-21)28(37)22-10-13-30-20(3)16-22/h10,13,16-19,21,23-24,36H,4-9,11-12,14-15H2,1-3H3,(H,31,32,33)/t19-,23-,24-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497269
PNG
((1-(2-fluoroethyl)piperidin- 4-yl)(4-(7-((1R,4S)-4...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CCN(CCF)CC1
Show InChI InChI=1S/C30H47FN6O2/c1-3-4-21(2)33-30-32-19-26-27(20-37(28(26)34-30)24-5-7-25(38)8-6-24)22-11-16-36(17-12-22)29(39)23-9-14-35(15-10-23)18-13-31/h19-25,38H,3-18H2,1-2H3,(H,32,33,34)/t21-,24-,25-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497275
PNG
((1S,4R)-4-(5-(1-((1- methylpiperidin-4- yl)methyl)...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC2CCN(C)CC2)CC1
Show InChI InChI=1S/C29H48N6O/c1-4-5-21(2)31-29-30-18-26-27(20-35(28(26)32-29)24-6-8-25(36)9-7-24)23-12-16-34(17-13-23)19-22-10-14-33(3)15-11-22/h18,20-25,36H,4-17,19H2,1-3H3,(H,30,31,32)/t21-,24-,25-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497280
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cncs1
Show InChI InChI=1S/C26H36N6O2S/c1-3-4-17(2)29-26-28-13-21-22(15-32(24(21)30-26)19-5-7-20(33)8-6-19)18-9-11-31(12-10-18)25(34)23-14-27-16-35-23/h13-20,33H,3-12H2,1-2H3,(H,28,29,30)/t17-,19-,20-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497284
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cccnn1
Show InChI InChI=1S/C27H37N7O2/c1-3-5-18(2)30-27-28-16-22-23(17-34(25(22)31-27)20-7-9-21(35)10-8-20)19-11-14-33(15-12-19)26(36)24-6-4-13-29-32-24/h4,6,13,16-21,35H,3,5,7-12,14-15H2,1-2H3,(H,28,30,31)/t18-,20-,21-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497285
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccnnc1
Show InChI InChI=1S/C27H37N7O2/c1-3-4-18(2)31-27-28-16-23-24(17-34(25(23)32-27)21-5-7-22(35)8-6-21)19-10-13-33(14-11-19)26(36)20-9-12-29-30-15-20/h9,12,15-19,21-22,35H,3-8,10-11,13-14H2,1-2H3,(H,28,31,32)/t18-,21-,22-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497302
PNG
((3,5-difluorophenyl)(4-(7- ((1r,4S)-4- hydroxycycl...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(F)cc(F)c1
Show InChI InChI=1S/C29H37F2N5O2/c1-3-4-18(2)33-29-32-16-25-26(17-36(27(25)34-29)23-5-7-24(37)8-6-23)19-9-11-35(12-10-19)28(38)20-13-21(30)15-22(31)14-20/h13-19,23-24,37H,3-12H2,1-2H3,(H,32,33,34)/t18-,23-,24-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497305
PNG
((4-chlorophenyl)(4-(7- ((1r,4S)-4- hydroxycyclohex...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H38ClN5O2/c1-3-4-19(2)32-29-31-17-25-26(18-35(27(25)33-29)23-9-11-24(36)12-10-23)20-13-15-34(16-14-20)28(37)21-5-7-22(30)8-6-21/h5-8,17-20,23-24,36H,3-4,9-16H2,1-2H3,(H,31,32,33)/t19-,23-,24-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497314
PNG
((1S,4r)-4-(5-(1- (cyclohexylmethyl)piperidin- 4-yl...)
Show SMILES C[C@H](Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC2CCCCC2)CC1)c1ccccc1
Show InChI InChI=1S/C32H45N5O/c1-23(25-10-6-3-7-11-25)34-32-33-20-29-30(22-37(31(29)35-32)27-12-14-28(38)15-13-27)26-16-18-36(19-17-26)21-24-8-4-2-5-9-24/h3,6-7,10-11,20,22-24,26-28,38H,2,4-5,8-9,12-19,21H2,1H3,(H,33,34,35)/t23-,27-,28-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497317
PNG
((4-(7-((1r,4S)-4- aminocyclohexyl)-2-(((S)- pentan...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](N)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1
Show InChI InChI=1S/C30H43N7O/c1-5-6-19(2)34-30-32-17-26-27(18-37(28(26)35-30)25-9-7-24(31)8-10-25)22-11-13-36(14-12-22)29(38)23-15-20(3)33-21(4)16-23/h15-19,22,24-25H,5-14,31H2,1-4H3,(H,32,34,35)/t19-,24-,25-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497322
PNG
((2,6-dimethylpyridin-4- yl)(4-(2-((4- hydroxybutyl...)
Show SMILES Cc1cc(cc(C)n1)C(=O)N1CCC(CC1)c1cn([C@H]2CC[C@H](O)CC2)c2nc(NCCCCO)ncc12
Show InChI InChI=1S/C29H40N6O3/c1-19-15-22(16-20(2)32-19)28(38)34-12-9-21(10-13-34)26-18-35(23-5-7-24(37)8-6-23)27-25(26)17-31-29(33-27)30-11-3-4-14-36/h15-18,21,23-24,36-37H,3-14H2,1-2H3,(H,30,31,33)/t23-,24-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497228
PNG
((1S,4R)-4-(5-(1-((1- methylpiperidin-4- yl)sulfony...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)S(=O)(=O)C1CCN(C)CC1
Show InChI InChI=1S/C28H46N6O3S/c1-4-5-20(2)30-28-29-18-25-26(19-34(27(25)31-28)22-6-8-23(35)9-7-22)21-10-16-33(17-11-21)38(36,37)24-12-14-32(3)15-13-24/h18-24,35H,4-17H2,1-3H3,(H,29,30,31)/t20-,22-,23-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497231
PNG
((1S,4R)-4-(5-(1-((2- methoxyethyl)sulfonyl) piperi...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)S(=O)(=O)CCOC
Show InChI InChI=1S/C25H41N5O4S/c1-4-5-18(2)27-25-26-16-22-23(17-30(24(22)28-25)20-6-8-21(31)9-7-20)19-10-12-29(13-11-19)35(32,33)15-14-34-3/h16-21,31H,4-15H2,1-3H3,(H,26,27,28)/t18-,20-,21-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497244
PNG
(7-((1R,4S)-4- hydroxycyclohexyl)-5-(1- (methylprol...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CCCN1C
Show InChI InChI=1S/C28H44N6O2/c1-4-6-19(2)30-28-29-17-23-24(18-34(26(23)31-28)21-8-10-22(35)11-9-21)20-12-15-33(16-13-20)27(36)25-7-5-14-32(25)3/h17-22,25,35H,4-16H2,1-3H3,(H,29,30,31)/t19-,21-,22-,25?/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497274
PNG
((1S,4R)-4-(2-(((S)-pentan- 2-yl)amino)-5-(1- (pipe...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC2CCNCC2)CC1
Show InChI InChI=1S/C28H46N6O/c1-3-4-20(2)31-28-30-17-25-26(19-34(27(25)32-28)23-5-7-24(35)8-6-23)22-11-15-33(16-12-22)18-21-9-13-29-14-10-21/h17,19-24,29,35H,3-16,18H2,1-2H3,(H,30,31,32)/t20-,23-,24-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497306
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccc(CNC)cc1
Show InChI InChI=1S/C31H44N6O2/c1-4-5-21(2)34-31-33-19-27-28(20-37(29(27)35-31)25-10-12-26(38)13-11-25)23-14-16-36(17-15-23)30(39)24-8-6-22(7-9-24)18-32-3/h6-9,19-21,23,25-26,32,38H,4-5,10-18H2,1-3H3,(H,33,34,35)/t21-,25-,26-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497312
PNG
((1S,4r)-4-(5-(1-((2,6- dimethylpyridin-4- yl)methy...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(Cc2cc(C)nc(C)c2)CC1
Show InChI InChI=1S/C30H44N6O/c1-5-6-20(2)33-30-31-17-27-28(19-36(29(27)34-30)25-7-9-26(37)10-8-25)24-11-13-35(14-12-24)18-23-15-21(3)32-22(4)16-23/h15-17,19-20,24-26,37H,5-14,18H2,1-4H3,(H,31,33,34)/t20-,25-,26-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497230
PNG
((1S,4R)-4-(2-(((S)-pentan- 2-yl)amino)-5-(1- (pipe...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)S(=O)(=O)C1CCNCC1
Show InChI InChI=1S/C27H44N6O3S/c1-3-4-19(2)30-27-29-17-24-25(18-33(26(24)31-27)21-5-7-22(34)8-6-21)20-11-15-32(16-12-20)37(35,36)23-9-13-28-14-10-23/h17-23,28,34H,3-16H2,1-2H3,(H,29,30,31)/t19-,21-,22-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497243
PNG
(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pentan-2...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CCCN1
Show InChI InChI=1S/C27H42N6O2/c1-3-5-18(2)30-27-29-16-22-23(17-33(25(22)31-27)20-7-9-21(34)10-8-20)19-11-14-32(15-12-19)26(35)24-6-4-13-28-24/h16-21,24,28,34H,3-15H2,1-2H3,(H,29,30,31)/t18-,20-,21-,24?/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497253
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)[C@@H]1CCCCN1C
Show InChI InChI=1S/C29H46N6O2/c1-4-7-20(2)31-29-30-18-24-25(19-35(27(24)32-29)22-9-11-23(36)12-10-22)21-13-16-34(17-14-21)28(37)26-8-5-6-15-33(26)3/h18-23,26,36H,4-17H2,1-3H3,(H,30,31,32)/t20-,22-,23-,26-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497254
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)[C@@H]1CCCNC1
Show InChI InChI=1S/C28H44N6O2/c1-3-5-19(2)31-28-30-17-24-25(18-34(26(24)32-28)22-7-9-23(35)10-8-22)20-11-14-33(15-12-20)27(36)21-6-4-13-29-16-21/h17-23,29,35H,3-16H2,1-2H3,(H,30,31,32)/t19-,21+,22-,23-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497258
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CCCN(C)C1
Show InChI InChI=1S/C29H46N6O2/c1-4-6-20(2)31-29-30-17-25-26(19-35(27(25)32-29)23-8-10-24(36)11-9-23)21-12-15-34(16-13-21)28(37)22-7-5-14-33(3)18-22/h17,19-24,36H,4-16,18H2,1-3H3,(H,30,31,32)/t20-,22?,23-,24-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497272
PNG
((1S,4R)-4-(5-([1,4'- bipiperidin]-4-yl)-2-(((S)- p...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C1CCNCC1
Show InChI InChI=1S/C27H44N6O/c1-3-4-19(2)30-27-29-17-24-25(18-33(26(24)31-27)22-5-7-23(34)8-6-22)20-11-15-32(16-12-20)21-9-13-28-14-10-21/h17-23,28,34H,3-16H2,1-2H3,(H,29,30,31)/t19-,22-,23-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497277
PNG
((2,6-dimethylpyridin-4- yl)(4-(2-(((1R,2R)-2- ethy...)
Show SMILES CC[C@@H]1C[C@H]1Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1
Show InChI InChI=1S/C30H40N6O2/c1-4-20-15-27(20)33-30-31-16-25-26(17-36(28(25)34-30)23-5-7-24(37)8-6-23)21-9-11-35(12-10-21)29(38)22-13-18(2)32-19(3)14-22/h13-14,16-17,20-21,23-24,27,37H,4-12,15H2,1-3H3,(H,31,33,34)/t20-,23-,24-,27-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497295
PNG
((2,6-dimethylpyridin-4- yl)(4-(7-((1r,4S)-4- hydro...)
Show SMILES C[C@H](Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1)c1ccccc1
Show InChI InChI=1S/C33H40N6O2/c1-21-17-26(18-22(2)35-21)32(41)38-15-13-25(14-16-38)30-20-39(27-9-11-28(40)12-10-27)31-29(30)19-34-33(37-31)36-23(3)24-7-5-4-6-8-24/h4-8,17-20,23,25,27-28,40H,9-16H2,1-3H3,(H,34,36,37)/t23-,27-,28-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497320
PNG
((1S,4r)-4-(2-(((S)-pentan-2- yl)amino)-5-(pyrrolid...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCNC1
Show InChI InChI=1S/C21H33N5O/c1-3-4-14(2)24-21-23-12-18-19(15-9-10-22-11-15)13-26(20(18)25-21)16-5-7-17(27)8-6-16/h12-17,22,27H,3-11H2,1-2H3,(H,23,24,25)/t14-,15?,16-,17-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497246
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CCN(C)C1
Show InChI InChI=1S/C28H44N6O2/c1-4-5-19(2)30-28-29-16-24-25(18-34(26(24)31-28)22-6-8-23(35)9-7-22)20-11-14-33(15-12-20)27(36)21-10-13-32(3)17-21/h16,18-23,35H,4-15,17H2,1-3H3,(H,29,30,31)/t19-,21?,22-,23-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497282
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc[nH]c1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497289
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cnccn1
Show InChI InChI=1S/C27H37N7O2/c1-3-4-18(2)31-27-30-15-22-23(17-34(25(22)32-27)20-5-7-21(35)8-6-20)19-9-13-33(14-10-19)26(36)24-16-28-11-12-29-24/h11-12,15-21,35H,3-10,13-14H2,1-2H3,(H,30,31,32)/t18-,20-,21-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497291
PNG
((4-(2-(butylamino)-7- ((1r,4r)-4- hydroxycyclohexy...)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1
Show InChI InChI=1S/C29H40N6O2/c1-4-5-12-30-29-31-17-25-26(18-35(27(25)33-29)23-6-8-24(36)9-7-23)21-10-13-34(14-11-21)28(37)22-15-19(2)32-20(3)16-22/h15-18,21,23-24,36H,4-14H2,1-3H3,(H,30,31,33)/t23-,24-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497296
PNG
((2,6-dimethylpyridin-4- yl)(4-(2-(((S)-1-(4- fluor...)
Show SMILES C[C@H](Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1)c1ccc(F)cc1
Show InChI InChI=1S/C33H39FN6O2/c1-20-16-25(17-21(2)36-20)32(42)39-14-12-24(13-15-39)30-19-40(27-8-10-28(41)11-9-27)31-29(30)18-35-33(38-31)37-22(3)23-4-6-26(34)7-5-23/h4-7,16-19,22,24,27-28,41H,8-15H2,1-3H3,(H,35,37,38)/t22-,27-,28-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497321
PNG
((1S,4r)-4-(5-(1- methylpyrrolidin-3-yl)-2- (((S)-p...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(C)C1
Show InChI InChI=1S/C22H35N5O/c1-4-5-15(2)24-22-23-12-19-20(16-10-11-26(3)13-16)14-27(21(19)25-22)17-6-8-18(28)9-7-17/h12,14-18,28H,4-11,13H2,1-3H3,(H,23,24,25)/t15-,16?,17-,18-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497233
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CCNCC1
Show InChI InChI=1S/C28H44N6O2/c1-3-4-19(2)31-28-30-17-24-25(18-34(26(24)32-28)22-5-7-23(35)8-6-22)20-11-15-33(16-12-20)27(36)21-9-13-29-14-10-21/h17-23,29,35H,3-16H2,1-2H3,(H,30,31,32)/t19-,22-,23-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497237
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CCOCC1
Show InChI InChI=1S/C28H43N5O3/c1-3-4-19(2)30-28-29-17-24-25(18-33(26(24)31-28)22-5-7-23(34)8-6-22)20-9-13-32(14-10-20)27(35)21-11-15-36-16-12-21/h17-23,34H,3-16H2,1-2H3,(H,29,30,31)/t19-,22-,23-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497245
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CCNC1
Show InChI InChI=1S/C27H42N6O2/c1-3-4-18(2)30-27-29-16-23-24(17-33(25(23)31-27)21-5-7-22(34)8-6-21)19-10-13-32(14-11-19)26(35)20-9-12-28-15-20/h16-22,28,34H,3-15H2,1-2H3,(H,29,30,31)/t18-,20?,21-,22-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497250
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CCCCN1C
Show InChI InChI=1S/C29H46N6O2/c1-4-7-20(2)31-29-30-18-24-25(19-35(27(24)32-29)22-9-11-23(36)12-10-22)21-13-16-34(17-14-21)28(37)26-8-5-6-15-33(26)3/h18-23,26,36H,4-17H2,1-3H3,(H,30,31,32)/t20-,22-,23-,26?/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497255
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)[C@H]1CCCNC1
Show InChI InChI=1S/C28H44N6O2/c1-3-5-19(2)31-28-30-17-24-25(18-34(26(24)32-28)22-7-9-23(35)10-8-22)20-11-14-33(15-12-20)27(36)21-6-4-13-29-16-21/h17-23,29,35H,3-16H2,1-2H3,(H,30,31,32)/t19-,21-,22-,23-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497276
PNG
((2,6-dimethylpyridin-4- yl)(4-(2-(((1S,2S)-2- ethy...)
Show SMILES CC[C@H]1C[C@@H]1Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1
Show InChI InChI=1S/C30H40N6O2/c1-4-20-15-27(20)33-30-31-16-25-26(17-36(28(25)34-30)23-5-7-24(37)8-6-23)21-9-11-35(12-10-21)29(38)22-13-18(2)32-19(3)14-22/h13-14,16-17,20-21,23-24,27,37H,4-12,15H2,1-3H3,(H,31,33,34)/t20-,23-,24-,27-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497301
PNG
((3,5-dimethoxyphenyl)(4- (7-((1r,4S)-4- hydroxycyc...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C31H43N5O4/c1-5-6-20(2)33-31-32-18-27-28(19-36(29(27)34-31)23-7-9-24(37)10-8-23)21-11-13-35(14-12-21)30(38)22-15-25(39-3)17-26(16-22)40-4/h15-21,23-24,37H,5-14H2,1-4H3,(H,32,33,34)/t20-,23-,24-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497303
PNG
((4-aminophenyl)(4-(7- ((1r,4S)-4- hydroxycyclohexy...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccc(N)cc1
Show InChI InChI=1S/C29H40N6O2/c1-3-4-19(2)32-29-31-17-25-26(18-35(27(25)33-29)23-9-11-24(36)12-10-23)20-13-15-34(16-14-20)28(37)21-5-7-22(30)8-6-21/h5-8,17-20,23-24,36H,3-4,9-16,30H2,1-2H3,(H,31,32,33)/t19-,23-,24-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497308
PNG
((2,6-dimethylpyridin-4- yl)(4-(7-((1r,4S)-4- hydro...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](CO)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1
Show InChI InChI=1S/C31H44N6O2/c1-5-6-20(2)34-31-32-17-27-28(18-37(29(27)35-31)26-9-7-23(19-38)8-10-26)24-11-13-36(14-12-24)30(39)25-15-21(3)33-22(4)16-25/h15-18,20,23-24,26,38H,5-14,19H2,1-4H3,(H,32,34,35)/t20-,23-,26-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497323
PNG
((2,6-dimethylpyridin-4- yl)(4-(7-((1r,4r)-4- hydro...)
Show SMILES Cc1cc(cc(C)n1)C(=O)N1CCC(CC1)c1cn([C@H]2CC[C@H](O)CC2)c2nc(NCCCC(F)(F)F)ncc12
Show InChI InChI=1S/C29H37F3N6O2/c1-18-14-21(15-19(2)35-18)27(40)37-12-8-20(9-13-37)25-17-38(22-4-6-23(39)7-5-22)26-24(25)16-34-28(36-26)33-11-3-10-29(30,31)32/h14-17,20,22-23,39H,3-13H2,1-2H3,(H,33,34,36)/t22-,23-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497229
PNG
((1S,4R)-4-(2-(((S)-pentan- 2-yl)amino)-5-(1- ((tet...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)S(=O)(=O)C1CCOCC1
Show InChI InChI=1S/C27H43N5O4S/c1-3-4-19(2)29-27-28-17-24-25(18-32(26(24)30-27)21-5-7-22(33)8-6-21)20-9-13-31(14-10-20)37(34,35)23-11-15-36-16-12-23/h17-23,33H,3-16H2,1-2H3,(H,28,29,30)/t19-,21-,22-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497238
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CCN(C)CC1
Show InChI InChI=1S/C29H46N6O2/c1-4-5-20(2)31-29-30-18-25-26(19-35(27(25)32-29)23-6-8-24(36)9-7-23)21-12-16-34(17-13-21)28(37)22-10-14-33(3)15-11-22/h18-24,36H,4-17H2,1-3H3,(H,30,31,32)/t20-,23-,24-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497264
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccc(OC)cc1
Show InChI InChI=1S/C30H41N5O3/c1-4-5-20(2)32-30-31-18-26-27(19-35(28(26)33-30)23-8-10-24(36)11-9-23)21-14-16-34(17-15-21)29(37)22-6-12-25(38-3)13-7-22/h6-7,12-13,18-21,23-24,36H,4-5,8-11,14-17H2,1-3H3,(H,31,32,33)/t20-,23-,24-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497266
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccccc1OC
Show InChI InChI=1S/C30H41N5O3/c1-4-7-20(2)32-30-31-18-25-26(19-35(28(25)33-30)22-10-12-23(36)13-11-22)21-14-16-34(17-15-21)29(37)24-8-5-6-9-27(24)38-3/h5-6,8-9,18-23,36H,4,7,10-17H2,1-3H3,(H,31,32,33)/t20-,22-,23-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497267
PNG
((2,6-dimethylpyridin-4- yl)(4-(7-((1R,4S)-4- hydro...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1
Show InChI InChI=1S/C30H42N6O2/c1-5-6-19(2)33-30-31-17-26-27(18-36(28(26)34-30)24-7-9-25(37)10-8-24)22-11-13-35(14-12-22)29(38)23-15-20(3)32-21(4)16-23/h15-19,22,24-25,37H,5-14H2,1-4H3,(H,31,33,34)/t19-,24-,25-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497273
PNG
((1S,4R)-4-(5-(1'-methyl- [1,4'-bipiperidin]-4-yl)-...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C1CCN(C)CC1
Show InChI InChI=1S/C28H46N6O/c1-4-5-20(2)30-28-29-18-25-26(19-34(27(25)31-28)23-6-8-24(35)9-7-23)21-10-16-33(17-11-21)22-12-14-32(3)15-13-22/h18-24,35H,4-17H2,1-3H3,(H,29,30,31)/t20-,23-,24-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497281
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccc[nH]1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497286
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ncccn1
Show InChI InChI=1S/C27H37N7O2/c1-3-5-18(2)31-27-30-16-22-23(17-34(25(22)32-27)20-6-8-21(35)9-7-20)19-10-14-33(15-11-19)26(36)24-28-12-4-13-29-24/h4,12-13,16-21,35H,3,5-11,14-15H2,1-2H3,(H,30,31,32)/t18-,20-,21-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497287
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccncn1
Show InChI InChI=1S/C27H37N7O2/c1-3-4-18(2)31-27-29-15-22-23(16-34(25(22)32-27)20-5-7-21(35)8-6-20)19-10-13-33(14-11-19)26(36)24-9-12-28-17-30-24/h9,12,15-21,35H,3-8,10-11,13-14H2,1-2H3,(H,29,31,32)/t18-,20-,21-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497288
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cncnc1
Show InChI InChI=1S/C27H37N7O2/c1-3-4-18(2)31-27-30-15-23-24(16-34(25(23)32-27)21-5-7-22(35)8-6-21)19-9-11-33(12-10-19)26(36)20-13-28-17-29-14-20/h13-19,21-22,35H,3-12H2,1-2H3,(H,30,31,32)/t18-,21-,22-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497290
PNG
((2,6-dimethylpyridin-4- yl)(4-(2-((2- ethylbutyl)a...)
Show SMILES CCC(CC)CNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1
Show InChI InChI=1S/C31H44N6O2/c1-5-22(6-2)17-32-31-33-18-27-28(19-37(29(27)35-31)25-7-9-26(38)10-8-25)23-11-13-36(14-12-23)30(39)24-15-20(3)34-21(4)16-24/h15-16,18-19,22-23,25-26,38H,5-14,17H2,1-4H3,(H,32,33,35)/t25-,26-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497293
PNG
((4-(2-((2- cyclopropylethyl)amino)-7- ((1r,4r)-4- ...)
Show SMILES Cc1cc(cc(C)n1)C(=O)N1CCC(CC1)c1cn([C@H]2CC[C@H](O)CC2)c2nc(NCCC3CC3)ncc12
Show InChI InChI=1S/C30H40N6O2/c1-19-15-23(16-20(2)33-19)29(38)35-13-10-22(11-14-35)27-18-36(24-5-7-25(37)8-6-24)28-26(27)17-32-30(34-28)31-12-9-21-3-4-21/h15-18,21-22,24-25,37H,3-14H2,1-2H3,(H,31,32,34)/t24-,25-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497300
PNG
((4- (dimethylamino)phenyl)(4- (7-((1r,4S)-4- hydro...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C31H44N6O2/c1-5-6-21(2)33-31-32-19-27-28(20-37(29(27)34-31)25-11-13-26(38)14-12-25)22-15-17-36(18-16-22)30(39)23-7-9-24(10-8-23)35(3)4/h7-10,19-22,25-26,38H,5-6,11-18H2,1-4H3,(H,32,33,34)/t21-,25-,26-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497309
PNG
((4- ((dimethylamino)methyl) phenyl)(4-(7-((1r,4S)-...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccc(CN(C)C)cc1
Show InChI InChI=1S/C32H46N6O2/c1-5-6-22(2)34-32-33-19-28-29(21-38(30(28)35-32)26-11-13-27(39)14-12-26)24-15-17-37(18-16-24)31(40)25-9-7-23(8-10-25)20-36(3)4/h7-10,19,21-22,24,26-27,39H,5-6,11-18,20H2,1-4H3,(H,33,34,35)/t22-,26-,27-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497310
PNG
((4-(7-((1r,4S)-4- (difluoromethyl)cyclohexyl)- 2-(...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@@H](CC3)C(F)F)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1
Show InChI InChI=1S/C31H42F2N6O/c1-5-6-19(2)36-31-34-17-26-27(18-39(29(26)37-31)25-9-7-23(8-10-25)28(32)33)22-11-13-38(14-12-22)30(40)24-15-20(3)35-21(4)16-24/h15-19,22-23,25,28H,5-14H2,1-4H3,(H,34,36,37)/t19-,23-,25-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497324
PNG
((4-(7-(((1r,4S)-4- aminocyclohexyl)methyl)- 2-(((S...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn(CC3CC[C@H](N)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1
Show InChI InChI=1S/C31H45N7O/c1-5-6-20(2)35-31-33-17-27-28(19-38(29(27)36-31)18-23-7-9-26(32)10-8-23)24-11-13-37(14-12-24)30(39)25-15-21(3)34-22(4)16-25/h15-17,19-20,23-24,26H,5-14,18,32H2,1-4H3,(H,33,35,36)/t20-,23?,26-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497236
PNG
(1-(4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pe...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)CCOC
Show InChI InChI=1S/C26H41N5O3/c1-4-5-18(2)28-26-27-16-22-23(19-10-13-30(14-11-19)24(33)12-15-34-3)17-31(25(22)29-26)20-6-8-21(32)9-7-20/h16-21,32H,4-15H2,1-3H3,(H,27,28,29)/t18-,20-,21-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497247
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CCCCN1
Show InChI InChI=1S/C28H44N6O2/c1-3-6-19(2)31-28-30-17-23-24(18-34(26(23)32-28)21-8-10-22(35)11-9-21)20-12-15-33(16-13-20)27(36)25-7-4-5-14-29-25/h17-22,25,29,35H,3-16H2,1-2H3,(H,30,31,32)/t19-,21-,22-,25?/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497278
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1nccs1
Show InChI InChI=1S/C26H36N6O2S/c1-3-4-17(2)29-26-28-15-21-22(16-32(23(21)30-26)19-5-7-20(33)8-6-19)18-9-12-31(13-10-18)25(34)24-27-11-14-35-24/h11,14-20,33H,3-10,12-13H2,1-2H3,(H,28,29,30)/t17-,19-,20-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497292
PNG
((3,5-dimethylphenyl)(4-(7- ((1r,4S)-4- hydroxycycl...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)cc(C)c1
Show InChI InChI=1S/C31H43N5O2/c1-5-6-22(4)33-31-32-18-27-28(19-36(29(27)34-31)25-7-9-26(37)10-8-25)23-11-13-35(14-12-23)30(38)24-16-20(2)15-21(3)17-24/h15-19,22-23,25-26,37H,5-14H2,1-4H3,(H,32,33,34)/t22-,25-,26-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497297
PNG
((4-(2- ((cyclohexylmethyl)amino)- 7-((1r,4r)-4- hy...)
Show SMILES Cc1cc(cc(C)n1)C(=O)N1CCC(CC1)c1cn([C@H]2CC[C@H](O)CC2)c2nc(NCC3CCCCC3)ncc12
Show InChI InChI=1S/C32H44N6O2/c1-21-16-25(17-22(2)35-21)31(40)37-14-12-24(13-15-37)29-20-38(26-8-10-27(39)11-9-26)30-28(29)19-34-32(36-30)33-18-23-6-4-3-5-7-23/h16-17,19-20,23-24,26-27,39H,3-15,18H2,1-2H3,(H,33,34,36)/t26-,27-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497232
PNG
((1S,4R)-4-(5-(1- (methylsulfonyl)piperidin- 4-yl)-...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C23H37N5O3S/c1-4-5-16(2)25-23-24-14-20-21(17-10-12-27(13-11-17)32(3,30)31)15-28(22(20)26-23)18-6-8-19(29)9-7-18/h14-19,29H,4-13H2,1-3H3,(H,24,25,26)/t16-,18-,19-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497241
PNG
(Azetidin-3-yl(4-(7- ((1R,4S)-4- hydroxycyclohexyl)...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CNC1
Show InChI InChI=1S/C26H40N6O2/c1-3-4-17(2)29-26-28-15-22-23(16-32(24(22)30-26)20-5-7-21(33)8-6-20)18-9-11-31(12-10-18)25(34)19-13-27-14-19/h15-21,27,33H,3-14H2,1-2H3,(H,28,29,30)/t17-,20-,21-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497259
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)[C@H]1CCCN(C)C1
Show InChI InChI=1S/C29H46N6O2/c1-4-6-20(2)31-29-30-17-25-26(19-35(27(25)32-29)23-8-10-24(36)11-9-23)21-12-15-34(16-13-21)28(37)22-7-5-14-33(3)18-22/h17,19-24,36H,4-16,18H2,1-3H3,(H,30,31,32)/t20-,22-,23-,24-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497261
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cccnc1
Show InChI InChI=1S/C28H38N6O2/c1-3-5-19(2)31-28-30-17-24-25(18-34(26(24)32-28)22-7-9-23(35)10-8-22)20-11-14-33(15-12-20)27(36)21-6-4-13-29-16-21/h4,6,13,16-20,22-23,35H,3,5,7-12,14-15H2,1-2H3,(H,30,31,32)/t19-,22-,23-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497262
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccccn1
Show InChI InChI=1S/C28H38N6O2/c1-3-6-19(2)31-28-30-17-23-24(18-34(26(23)32-28)21-8-10-22(35)11-9-21)20-12-15-33(16-13-20)27(36)25-7-4-5-14-29-25/h4-5,7,14,17-22,35H,3,6,8-13,15-16H2,1-2H3,(H,30,31,32)/t19-,21-,22-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497270
PNG
((4-(2-(((1S,2S)-2- ethylcyclopropyl)amino)-7- ((1R...)
Show SMILES CC[C@H]1C[C@@H]1Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccncc1
Show InChI InChI=1S/C28H36N6O2/c1-2-18-15-25(18)31-28-30-16-23-24(17-34(26(23)32-28)21-3-5-22(35)6-4-21)19-9-13-33(14-10-19)27(36)20-7-11-29-12-8-20/h7-8,11-12,16-19,21-22,25,35H,2-6,9-10,13-15H2,1H3,(H,30,31,32)/t18-,21-,22-,25-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497271
PNG
((4-(2-(((1R,2R)-2- ethylcyclopropyl)amino)-7- ((1R...)
Show SMILES CC[C@@H]1C[C@H]1Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccncc1
Show InChI InChI=1S/C28H36N6O2/c1-2-18-15-25(18)31-28-30-16-23-24(17-34(26(23)32-28)21-3-5-22(35)6-4-21)19-9-13-33(14-10-19)27(36)20-7-11-29-12-8-20/h7-8,11-12,16-19,21-22,25,35H,2-6,9-10,13-15H2,1H3,(H,30,31,32)/t18-,21-,22-,25-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497279
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cscn1
Show InChI InChI=1S/C26H36N6O2S/c1-3-4-17(2)29-26-27-13-21-22(14-32(24(21)30-26)19-5-7-20(33)8-6-19)18-9-11-31(12-10-18)25(34)23-15-35-16-28-23/h13-20,33H,3-12H2,1-2H3,(H,27,29,30)/t17-,19-,20-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497283
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ncc[nH]1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497294
PNG
((4-(2-(benzylamino)-7- ((1r,4r)-4- hydroxycyclohex...)
Show SMILES Cc1cc(cc(C)n1)C(=O)N1CCC(CC1)c1cn([C@H]2CC[C@H](O)CC2)c2nc(NCc3ccccc3)ncc12
Show InChI InChI=1S/C32H38N6O2/c1-21-16-25(17-22(2)35-21)31(40)37-14-12-24(13-15-37)29-20-38(26-8-10-27(39)11-9-26)30-28(29)19-34-32(36-30)33-18-23-6-4-3-5-7-23/h3-7,16-17,19-20,24,26-27,39H,8-15,18H2,1-2H3,(H,33,34,36)/t26-,27-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497304
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccc(NC)cc1
Show InChI InChI=1S/C30H42N6O2/c1-4-5-20(2)33-30-32-18-26-27(19-36(28(26)34-30)24-10-12-25(37)13-11-24)21-14-16-35(17-15-21)29(38)22-6-8-23(31-3)9-7-22/h6-9,18-21,24-25,31,37H,4-5,10-17H2,1-3H3,(H,32,33,34)/t20-,24-,25-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497311
PNG
((4-fluorophenyl)(4-(7- ((1r,4S)-4- hydroxycyclohex...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C29H38FN5O2/c1-3-4-19(2)32-29-31-17-25-26(18-35(27(25)33-29)23-9-11-24(36)12-10-23)20-13-15-34(16-14-20)28(37)21-5-7-22(30)8-6-21/h5-8,17-20,23-24,36H,3-4,9-16H2,1-2H3,(H,31,32,33)/t19-,23-,24-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497242
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CN(C)C1
Show InChI InChI=1S/C27H42N6O2/c1-4-5-18(2)29-27-28-14-23-24(17-33(25(23)30-27)21-6-8-22(34)9-7-21)19-10-12-32(13-11-19)26(35)20-15-31(3)16-20/h14,17-22,34H,4-13,15-16H2,1-3H3,(H,28,29,30)/t18-,21-,22-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<3n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497239
PNG
((1R,4R)-4-(5-((1R,3S,5S)- 8-azabicyclo[3.2.1]octan...)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CC2CCC(C1)N2
Show InChI InChI=1S/C23H35N5O/c1-2-3-10-24-23-25-13-20-21(15-11-16-4-5-17(12-15)26-16)14-28(22(20)27-23)18-6-8-19(29)9-7-18/h13-19,26,29H,2-12H2,1H3,(H,24,25,27)/t15?,16?,17?,18-,19-
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497322
PNG
((2,6-dimethylpyridin-4- yl)(4-(2-((4- hydroxybutyl...)
Show SMILES Cc1cc(cc(C)n1)C(=O)N1CCC(CC1)c1cn([C@H]2CC[C@H](O)CC2)c2nc(NCCCCO)ncc12
Show InChI InChI=1S/C29H40N6O3/c1-19-15-22(16-20(2)32-19)28(38)34-12-9-21(10-13-34)26-18-35(23-5-7-24(37)8-6-23)27-25(26)17-31-29(33-27)30-11-3-4-14-36/h15-18,21,23-24,36-37H,3-14H2,1-2H3,(H,30,31,33)/t23-,24-
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497297
PNG
((4-(2- ((cyclohexylmethyl)amino)- 7-((1r,4r)-4- hy...)
Show SMILES Cc1cc(cc(C)n1)C(=O)N1CCC(CC1)c1cn([C@H]2CC[C@H](O)CC2)c2nc(NCC3CCCCC3)ncc12
Show InChI InChI=1S/C32H44N6O2/c1-21-16-25(17-22(2)35-21)31(40)37-14-12-24(13-15-37)29-20-38(26-8-10-27(39)11-9-26)30-28(29)19-34-32(36-30)33-18-23-6-4-3-5-7-23/h16-17,19-20,23-24,26-27,39H,3-15,18H2,1-2H3,(H,33,34,36)/t26-,27-
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497323
PNG
((2,6-dimethylpyridin-4- yl)(4-(7-((1r,4r)-4- hydro...)
Show SMILES Cc1cc(cc(C)n1)C(=O)N1CCC(CC1)c1cn([C@H]2CC[C@H](O)CC2)c2nc(NCCCC(F)(F)F)ncc12
Show InChI InChI=1S/C29H37F3N6O2/c1-18-14-21(15-19(2)35-18)27(40)37-12-8-20(9-13-37)25-17-38(22-4-6-23(39)7-5-22)26-24(25)16-34-28(36-26)33-11-3-10-29(30,31)32/h14-17,20,22-23,39H,3-13H2,1-2H3,(H,33,34,36)/t22-,23-
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497299
PNG
((4-(2-(((S)-2,3-dihydro-1H- inden-1-yl)amino)-7- (...)
Show SMILES Cc1cc(cc(C)n1)C(=O)N1CCC(CC1)c1cn([C@H]2CC[C@H](O)CC2)c2nc(N[C@H]3CCc4ccccc34)ncc12
Show InChI InChI=1S/C34H40N6O2/c1-21-17-25(18-22(2)36-21)33(42)39-15-13-24(14-16-39)30-20-40(26-8-10-27(41)11-9-26)32-29(30)19-35-34(38-32)37-31-12-7-23-5-3-4-6-28(23)31/h3-6,17-20,24,26-27,31,41H,7-16H2,1-2H3,(H,35,37,38)/t26-,27-,31-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497319
PNG
((2,6-dimethylpyridin-4- yl)(3-(7-((1r,4S)-4- hydro...)
Show SMILES C[C@H](Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(C1)C(=O)c1cc(C)nc(C)c1)c1ccccc1
Show InChI InChI=1S/C32H38N6O2/c1-20-15-25(16-21(2)34-20)31(40)37-14-13-24(18-37)29-19-38(26-9-11-27(39)12-10-26)30-28(29)17-33-32(36-30)35-22(3)23-7-5-4-6-8-23/h4-8,15-17,19,22,24,26-27,39H,9-14,18H2,1-3H3,(H,33,35,36)/t22-,24?,26-,27-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497247
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CCCCN1
Show InChI InChI=1S/C28H44N6O2/c1-3-6-19(2)31-28-30-17-23-24(18-34(26(23)32-28)21-8-10-22(35)11-9-21)20-12-15-33(16-13-20)27(36)25-7-4-5-14-29-25/h17-22,25,29,35H,3-16H2,1-2H3,(H,30,31,32)/t19-,21-,22-,25?/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497271
PNG
((4-(2-(((1R,2R)-2- ethylcyclopropyl)amino)-7- ((1R...)
Show SMILES CC[C@@H]1C[C@H]1Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccncc1
Show InChI InChI=1S/C28H36N6O2/c1-2-18-15-25(18)31-28-30-16-23-24(17-34(26(23)32-28)21-3-5-22(35)6-4-21)19-9-13-33(14-10-19)27(36)20-7-11-29-12-8-20/h7-8,11-12,16-19,21-22,25,35H,2-6,9-10,13-15H2,1H3,(H,30,31,32)/t18-,21-,22-,25-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497293
PNG
((4-(2-((2- cyclopropylethyl)amino)-7- ((1r,4r)-4- ...)
Show SMILES Cc1cc(cc(C)n1)C(=O)N1CCC(CC1)c1cn([C@H]2CC[C@H](O)CC2)c2nc(NCCC3CC3)ncc12
Show InChI InChI=1S/C30H40N6O2/c1-19-15-23(16-20(2)33-19)29(38)35-13-10-22(11-14-35)27-18-36(24-5-7-25(37)8-6-24)28-26(27)17-32-30(34-28)31-12-9-21-3-4-21/h15-18,21-22,24-25,37H,3-14H2,1-2H3,(H,31,32,34)/t24-,25-
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497321
PNG
((1S,4r)-4-(5-(1- methylpyrrolidin-3-yl)-2- (((S)-p...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(C)C1
Show InChI InChI=1S/C22H35N5O/c1-4-5-15(2)24-22-23-12-19-20(16-10-11-26(3)13-16)14-27(21(19)25-22)17-6-8-18(28)9-7-17/h12,14-18,28H,4-11,13H2,1-3H3,(H,23,24,25)/t15-,16?,17-,18-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497236
PNG
(1-(4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pe...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)CCOC
Show InChI InChI=1S/C26H41N5O3/c1-4-5-18(2)28-26-27-16-22-23(19-10-13-30(14-11-19)24(33)12-15-34-3)17-31(25(22)29-26)20-6-8-21(32)9-7-20/h16-21,32H,4-15H2,1-3H3,(H,27,28,29)/t18-,20-,21-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497278
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1nccs1
Show InChI InChI=1S/C26H36N6O2S/c1-3-4-17(2)29-26-28-15-21-22(16-32(23(21)30-26)19-5-7-20(33)8-6-19)18-9-12-31(13-10-18)25(34)24-27-11-14-35-24/h11,14-20,33H,3-10,12-13H2,1-2H3,(H,28,29,30)/t17-,19-,20-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497283
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ncc[nH]1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497303
PNG
((4-aminophenyl)(4-(7- ((1r,4S)-4- hydroxycyclohexy...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccc(N)cc1
Show InChI InChI=1S/C29H40N6O2/c1-3-4-19(2)32-29-31-17-25-26(18-35(27(25)33-29)23-9-11-24(36)12-10-23)20-13-15-34(16-14-20)28(37)21-5-7-22(30)8-6-21/h5-8,17-20,23-24,36H,3-4,9-16,30H2,1-2H3,(H,31,32,33)/t19-,23-,24-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497315
PNG
((1S,4r)-4-(5-(1- ethylpiperidin-4-yl)-2-(((S)- 1-p...)
Show SMILES CCN1CCC(CC1)c1cn([C@H]2CC[C@H](O)CC2)c2nc(N[C@@H](C)c3ccccc3)ncc12
Show InChI InChI=1S/C27H37N5O/c1-3-31-15-13-21(14-16-31)25-18-32(22-9-11-23(33)12-10-22)26-24(25)17-28-27(30-26)29-19(2)20-7-5-4-6-8-20/h4-8,17-19,21-23,33H,3,9-16H2,1-2H3,(H,28,29,30)/t19-,22-,23-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497229
PNG
((1S,4R)-4-(2-(((S)-pentan- 2-yl)amino)-5-(1- ((tet...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)S(=O)(=O)C1CCOCC1
Show InChI InChI=1S/C27H43N5O4S/c1-3-4-19(2)29-27-28-17-24-25(18-32(26(24)30-27)21-5-7-22(33)8-6-21)20-9-13-31(14-10-20)37(34,35)23-11-15-36-16-12-23/h17-23,33H,3-16H2,1-2H3,(H,28,29,30)/t19-,21-,22-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497262
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccccn1
Show InChI InChI=1S/C28H38N6O2/c1-3-6-19(2)31-28-30-17-23-24(18-34(26(23)32-28)21-8-10-22(35)11-9-21)20-12-15-33(16-13-20)27(36)25-7-4-5-14-29-25/h4-5,7,14,17-22,35H,3,6,8-13,15-16H2,1-2H3,(H,30,31,32)/t19-,21-,22-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497265
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cccc(OC)c1
Show InChI InChI=1S/C30H41N5O3/c1-4-6-20(2)32-30-31-18-26-27(19-35(28(26)33-30)23-9-11-24(36)12-10-23)21-13-15-34(16-14-21)29(37)22-7-5-8-25(17-22)38-3/h5,7-8,17-21,23-24,36H,4,6,9-16H2,1-3H3,(H,31,32,33)/t20-,23-,24-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497266
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccccc1OC
Show InChI InChI=1S/C30H41N5O3/c1-4-7-20(2)32-30-31-18-25-26(19-35(28(25)33-30)22-10-12-23(36)13-11-22)21-14-16-34(17-15-21)29(37)24-8-5-6-9-27(24)38-3/h5-6,8-9,18-23,36H,4,7,10-17H2,1-3H3,(H,31,32,33)/t20-,22-,23-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497281
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccc[nH]1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497289
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cnccn1
Show InChI InChI=1S/C27H37N7O2/c1-3-4-18(2)31-27-30-15-22-23(17-34(25(22)32-27)20-5-7-21(35)8-6-20)19-9-13-33(14-10-19)26(36)24-16-28-11-12-29-24/h11-12,15-21,35H,3-10,13-14H2,1-2H3,(H,30,31,32)/t18-,20-,21-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497305
PNG
((4-chlorophenyl)(4-(7- ((1r,4S)-4- hydroxycyclohex...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H38ClN5O2/c1-3-4-19(2)32-29-31-17-25-26(18-35(27(25)33-29)23-9-11-24(36)12-10-23)20-13-15-34(16-14-20)28(37)21-5-7-22(30)8-6-21/h5-8,17-20,23-24,36H,3-4,9-16H2,1-2H3,(H,31,32,33)/t19-,23-,24-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497313
PNG
((1S,4r)-4-(5-(1-((2,6- dimethylpyridin-4- yl)methy...)
Show SMILES C[C@H](Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(Cc2cc(C)nc(C)c2)CC1)c1ccccc1
Show InChI InChI=1S/C33H42N6O/c1-22-17-25(18-23(2)35-22)20-38-15-13-27(14-16-38)31-21-39(28-9-11-29(40)12-10-28)32-30(31)19-34-33(37-32)36-24(3)26-7-5-4-6-8-26/h4-8,17-19,21,24,27-29,40H,9-16,20H2,1-3H3,(H,34,36,37)/t24-,28-,29-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497319
PNG
((2,6-dimethylpyridin-4- yl)(3-(7-((1r,4S)-4- hydro...)
Show SMILES C[C@H](Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(C1)C(=O)c1cc(C)nc(C)c1)c1ccccc1
Show InChI InChI=1S/C32H38N6O2/c1-20-15-25(16-21(2)34-20)31(40)37-14-13-24(18-37)29-19-38(26-9-11-27(39)12-10-26)30-28(29)17-33-32(36-30)35-22(3)23-7-5-4-6-8-23/h4-8,15-17,19,22,24,26-27,39H,9-14,18H2,1-3H3,(H,33,35,36)/t22-,24?,26-,27-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497325
PNG
((2,6-dimethylpyridin-4- yl)(4-(7-(((1r,4S)-4- hydr...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn(CC3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1
Show InChI InChI=1S/C31H44N6O2/c1-5-6-20(2)34-31-32-17-27-28(19-37(29(27)35-31)18-23-7-9-26(38)10-8-23)24-11-13-36(14-12-24)30(39)25-15-21(3)33-22(4)16-25/h15-17,19-20,23-24,26,38H,5-14,18H2,1-4H3,(H,32,34,35)/t20-,23?,26-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497232
PNG
((1S,4R)-4-(5-(1- (methylsulfonyl)piperidin- 4-yl)-...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C23H37N5O3S/c1-4-5-16(2)25-23-24-14-20-21(17-10-12-27(13-11-17)32(3,30)31)15-28(22(20)26-23)18-6-8-19(29)9-7-18/h14-19,29H,4-13H2,1-3H3,(H,24,25,26)/t16-,18-,19-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497261
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cccnc1
Show InChI InChI=1S/C28H38N6O2/c1-3-5-19(2)31-28-30-17-24-25(18-34(26(24)32-28)22-7-9-23(35)10-8-22)20-11-14-33(15-12-20)27(36)21-6-4-13-29-16-21/h4,6,13,16-20,22-23,35H,3,5,7-12,14-15H2,1-2H3,(H,30,31,32)/t19-,22-,23-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497282
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc[nH]c1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497284
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cccnn1
Show InChI InChI=1S/C27H37N7O2/c1-3-5-18(2)30-27-28-16-22-23(17-34(25(22)31-27)20-7-9-21(35)10-8-20)19-11-14-33(15-12-19)26(36)24-6-4-13-29-32-24/h4,6,13,16-21,35H,3,5,7-12,14-15H2,1-2H3,(H,28,30,31)/t18-,20-,21-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497292
PNG
((3,5-dimethylphenyl)(4-(7- ((1r,4S)-4- hydroxycycl...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)cc(C)c1
Show InChI InChI=1S/C31H43N5O2/c1-5-6-22(4)33-31-32-18-27-28(19-36(29(27)34-31)25-7-9-26(37)10-8-25)23-11-13-35(14-12-23)30(38)24-16-20(2)15-21(3)17-24/h15-19,22-23,25-26,37H,5-14H2,1-4H3,(H,32,33,34)/t22-,25-,26-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497295
PNG
((2,6-dimethylpyridin-4- yl)(4-(7-((1r,4S)-4- hydro...)
Show SMILES C[C@H](Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1)c1ccccc1
Show InChI InChI=1S/C33H40N6O2/c1-21-17-26(18-22(2)35-21)32(41)38-15-13-25(14-16-38)30-20-39(27-9-11-28(40)12-10-27)31-29(30)19-34-33(37-31)36-23(3)24-7-5-4-6-8-24/h4-8,17-20,23,25,27-28,40H,9-16H2,1-3H3,(H,34,36,37)/t23-,27-,28-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497301
PNG
((3,5-dimethoxyphenyl)(4- (7-((1r,4S)-4- hydroxycyc...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C31H43N5O4/c1-5-6-20(2)33-31-32-18-27-28(19-36(29(27)34-31)23-7-9-24(37)10-8-23)21-11-13-35(14-12-21)30(38)22-15-25(39-3)17-26(16-22)40-4/h15-21,23-24,37H,5-14H2,1-4H3,(H,32,33,34)/t20-,23-,24-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497312
PNG
((1S,4r)-4-(5-(1-((2,6- dimethylpyridin-4- yl)methy...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(Cc2cc(C)nc(C)c2)CC1
Show InChI InChI=1S/C30H44N6O/c1-5-6-20(2)33-30-31-17-27-28(19-36(29(27)34-30)25-7-9-26(37)10-8-25)24-11-13-35(14-12-24)18-23-15-21(3)32-22(4)16-23/h15-17,19-20,24-26,37H,5-14,18H2,1-4H3,(H,31,33,34)/t20-,25-,26-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497318
PNG
((2,6-dimethylpyridin-4- yl)(3-(7-((1r,4S)-4- hydro...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(C1)C(=O)c1cc(C)nc(C)c1
Show InChI InChI=1S/C29H40N6O2/c1-5-6-18(2)32-29-30-15-25-26(17-35(27(25)33-29)23-7-9-24(36)10-8-23)21-11-12-34(16-21)28(37)22-13-19(3)31-20(4)14-22/h13-15,17-18,21,23-24,36H,5-12,16H2,1-4H3,(H,30,32,33)/t18-,21?,23-,24-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497324
PNG
((4-(7-(((1r,4S)-4- aminocyclohexyl)methyl)- 2-(((S...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn(CC3CC[C@H](N)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1
Show InChI InChI=1S/C31H45N7O/c1-5-6-20(2)35-31-33-17-27-28(19-38(29(27)36-31)18-23-7-9-26(32)10-8-23)24-11-13-37(14-12-24)30(39)25-15-21(3)34-22(4)16-25/h15-17,19-20,23-24,26H,5-14,18,32H2,1-4H3,(H,33,35,36)/t20-,23?,26-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497264
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccc(OC)cc1
Show InChI InChI=1S/C30H41N5O3/c1-4-5-20(2)32-30-31-18-26-27(19-35(28(26)33-30)23-8-10-24(36)11-9-23)21-14-16-34(17-15-21)29(37)22-6-12-25(38-3)13-7-22/h6-7,12-13,18-21,23-24,36H,4-5,8-11,14-17H2,1-3H3,(H,31,32,33)/t20-,23-,24-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497270
PNG
((4-(2-(((1S,2S)-2- ethylcyclopropyl)amino)-7- ((1R...)
Show SMILES CC[C@H]1C[C@@H]1Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccncc1
Show InChI InChI=1S/C28H36N6O2/c1-2-18-15-25(18)31-28-30-16-23-24(17-34(26(23)32-28)21-3-5-22(35)6-4-21)19-9-13-33(14-10-19)27(36)20-7-11-29-12-8-20/h7-8,11-12,16-19,21-22,25,35H,2-6,9-10,13-15H2,1H3,(H,30,31,32)/t18-,21-,22-,25-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497300
PNG
((4- (dimethylamino)phenyl)(4- (7-((1r,4S)-4- hydro...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C31H44N6O2/c1-5-6-21(2)33-31-32-19-27-28(20-37(29(27)34-31)25-11-13-26(38)14-12-25)22-15-17-36(18-16-22)30(39)23-7-9-24(10-8-23)35(3)4/h7-10,19-22,25-26,38H,5-6,11-18H2,1-4H3,(H,32,33,34)/t21-,25-,26-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497310
PNG
((4-(7-((1r,4S)-4- (difluoromethyl)cyclohexyl)- 2-(...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@@H](CC3)C(F)F)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1
Show InChI InChI=1S/C31H42F2N6O/c1-5-6-19(2)36-31-34-17-26-27(18-39(29(26)37-31)25-9-7-23(8-10-25)28(32)33)22-11-13-38(14-12-22)30(40)24-15-20(3)35-21(4)16-24/h15-19,22-23,25,28H,5-14H2,1-4H3,(H,34,36,37)/t19-,23-,25-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497316
PNG
((1S,4r)-4-(5-(1- isopropylpiperidin-4-yl)-2- (((S)...)
Show SMILES CC(C)N1CCC(CC1)c1cn([C@H]2CC[C@H](O)CC2)c2nc(N[C@@H](C)c3ccccc3)ncc12
Show InChI InChI=1S/C28H39N5O/c1-19(2)32-15-13-22(14-16-32)26-18-33(23-9-11-24(34)12-10-23)27-25(26)17-29-28(31-27)30-20(3)21-7-5-4-6-8-21/h4-8,17-20,22-24,34H,9-16H2,1-3H3,(H,29,30,31)/t20-,23-,24-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497231
PNG
((1S,4R)-4-(5-(1-((2- methoxyethyl)sulfonyl) piperi...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)S(=O)(=O)CCOC
Show InChI InChI=1S/C25H41N5O4S/c1-4-5-18(2)27-25-26-16-22-23(17-30(24(22)28-25)20-6-8-21(31)9-7-20)19-10-12-29(13-11-19)35(32,33)15-14-34-3/h16-21,31H,4-15H2,1-3H3,(H,26,27,28)/t18-,20-,21-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497291
PNG
((4-(2-(butylamino)-7- ((1r,4r)-4- hydroxycyclohexy...)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1
Show InChI InChI=1S/C29H40N6O2/c1-4-5-12-30-29-31-17-25-26(18-35(27(25)33-29)23-6-8-24(36)9-7-23)21-10-13-34(14-11-21)28(37)22-15-19(2)32-20(3)16-22/h15-18,21,23-24,36H,4-14H2,1-3H3,(H,30,31,33)/t23-,24-
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497302
PNG
((3,5-difluorophenyl)(4-(7- ((1r,4S)-4- hydroxycycl...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(F)cc(F)c1
Show InChI InChI=1S/C29H37F2N5O2/c1-3-4-18(2)33-29-32-16-25-26(17-36(27(25)34-29)23-5-7-24(37)8-6-23)19-9-11-35(12-10-19)28(38)20-13-21(30)15-22(31)14-20/h13-19,23-24,37H,3-12H2,1-2H3,(H,32,33,34)/t18-,23-,24-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497311
PNG
((4-fluorophenyl)(4-(7- ((1r,4S)-4- hydroxycyclohex...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C29H38FN5O2/c1-3-4-19(2)32-29-31-17-25-26(18-35(27(25)33-29)23-9-11-24(36)12-10-23)20-13-15-34(16-14-20)28(37)21-5-7-22(30)8-6-21/h5-8,17-20,23-24,36H,3-4,9-16H2,1-2H3,(H,31,32,33)/t19-,23-,24-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497294
PNG
((4-(2-(benzylamino)-7- ((1r,4r)-4- hydroxycyclohex...)
Show SMILES Cc1cc(cc(C)n1)C(=O)N1CCC(CC1)c1cn([C@H]2CC[C@H](O)CC2)c2nc(NCc3ccccc3)ncc12
Show InChI InChI=1S/C32H38N6O2/c1-21-16-25(17-22(2)35-21)31(40)37-14-12-24(13-15-37)29-20-38(26-8-10-27(39)11-9-26)30-28(29)19-34-32(36-30)33-18-23-6-4-3-5-7-23/h3-7,16-17,19-20,24,26-27,39H,8-15,18H2,1-2H3,(H,33,34,36)/t26-,27-
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497298
PNG
((4-(2-(((R)-2,3-dihydro-1H- inden-1-yl)amino)-7- (...)
Show SMILES Cc1cc(cc(C)n1)C(=O)N1CCC(CC1)c1cn([C@H]2CC[C@H](O)CC2)c2nc(N[C@@H]3CCc4ccccc34)ncc12
Show InChI InChI=1S/C34H40N6O2/c1-21-17-25(18-22(2)36-21)33(42)39-15-13-24(14-16-39)30-20-40(26-8-10-27(41)11-9-26)32-29(30)19-35-34(38-32)37-31-12-7-23-5-3-4-6-28(23)31/h3-6,17-20,24,26-27,31,41H,7-16H2,1-2H3,(H,35,37,38)/t26-,27-,31-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497314
PNG
((1S,4r)-4-(5-(1- (cyclohexylmethyl)piperidin- 4-yl...)
Show SMILES C[C@H](Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC2CCCCC2)CC1)c1ccccc1
Show InChI InChI=1S/C32H45N5O/c1-23(25-10-6-3-7-11-25)34-32-33-20-29-30(22-37(31(29)35-32)27-12-14-28(38)15-13-27)26-16-18-36(19-17-26)21-24-8-4-2-5-9-24/h3,6-7,10-11,20,22-24,26-28,38H,2,4-5,8-9,12-19,21H2,1H3,(H,33,34,35)/t23-,27-,28-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 275n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497238
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CCN(C)CC1
Show InChI InChI=1S/C29H46N6O2/c1-4-5-20(2)31-29-30-18-25-26(19-35(27(25)32-29)23-6-8-24(36)9-7-23)21-12-16-34(17-13-21)28(37)22-10-14-33(3)15-11-22/h18-24,36H,4-17H2,1-3H3,(H,30,31,32)/t20-,23-,24-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497318
PNG
((2,6-dimethylpyridin-4- yl)(3-(7-((1r,4S)-4- hydro...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(C1)C(=O)c1cc(C)nc(C)c1
Show InChI InChI=1S/C29H40N6O2/c1-5-6-18(2)32-29-30-15-25-26(17-35(27(25)33-29)23-7-9-24(36)10-8-23)21-11-12-34(16-21)28(37)22-13-19(3)31-20(4)14-22/h13-15,17-18,21,23-24,36H,5-12,16H2,1-4H3,(H,30,32,33)/t18-,21?,23-,24-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497299
PNG
((4-(2-(((S)-2,3-dihydro-1H- inden-1-yl)amino)-7- (...)
Show SMILES Cc1cc(cc(C)n1)C(=O)N1CCC(CC1)c1cn([C@H]2CC[C@H](O)CC2)c2nc(N[C@H]3CCc4ccccc34)ncc12
Show InChI InChI=1S/C34H40N6O2/c1-21-17-25(18-22(2)36-21)33(42)39-15-13-24(14-16-39)30-20-40(26-8-10-27(41)11-9-26)32-29(30)19-35-34(38-32)37-31-12-7-23-5-3-4-6-28(23)31/h3-6,17-20,24,26-27,31,41H,7-16H2,1-2H3,(H,35,37,38)/t26-,27-,31-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497247
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CCCCN1
Show InChI InChI=1S/C28H44N6O2/c1-3-6-19(2)31-28-30-17-23-24(18-34(26(23)32-28)21-8-10-22(35)11-9-21)20-12-15-33(16-13-20)27(36)25-7-4-5-14-29-25/h17-22,25,29,35H,3-16H2,1-2H3,(H,30,31,32)/t19-,21-,22-,25?/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497250
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CCCCN1C
Show InChI InChI=1S/C29H46N6O2/c1-4-7-20(2)31-29-30-18-24-25(19-35(27(24)32-29)22-9-11-23(36)12-10-22)21-13-16-34(17-14-21)28(37)26-8-5-6-15-33(26)3/h18-23,26,36H,4-17H2,1-3H3,(H,30,31,32)/t20-,22-,23-,26?/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497280
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cncs1
Show InChI InChI=1S/C26H36N6O2S/c1-3-4-17(2)29-26-28-13-21-22(15-32(24(21)30-26)19-5-7-20(33)8-6-19)18-9-11-31(12-10-18)25(34)23-14-27-16-35-23/h13-20,33H,3-12H2,1-2H3,(H,28,29,30)/t17-,19-,20-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497308
PNG
((2,6-dimethylpyridin-4- yl)(4-(7-((1r,4S)-4- hydro...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](CO)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1
Show InChI InChI=1S/C31H44N6O2/c1-5-6-20(2)34-31-32-17-27-28(18-37(29(27)35-31)26-9-7-23(19-38)8-10-26)24-11-13-36(14-12-24)30(39)25-15-21(3)33-22(4)16-25/h15-18,20,23-24,26,38H,5-14,19H2,1-4H3,(H,32,34,35)/t20-,23-,26-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497315
PNG
((1S,4r)-4-(5-(1- ethylpiperidin-4-yl)-2-(((S)- 1-p...)
Show SMILES CCN1CCC(CC1)c1cn([C@H]2CC[C@H](O)CC2)c2nc(N[C@@H](C)c3ccccc3)ncc12
Show InChI InChI=1S/C27H37N5O/c1-3-31-15-13-21(14-16-31)25-18-32(22-9-11-23(33)12-10-22)26-24(25)17-28-27(30-26)29-19(2)20-7-5-4-6-8-20/h4-8,17-19,21-23,33H,3,9-16H2,1-2H3,(H,28,29,30)/t19-,22-,23-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497317
PNG
((4-(7-((1r,4S)-4- aminocyclohexyl)-2-(((S)- pentan...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](N)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1
Show InChI InChI=1S/C30H43N7O/c1-5-6-19(2)34-30-32-17-26-27(18-37(28(26)35-30)25-9-7-24(31)8-10-25)22-11-13-36(14-12-22)29(38)23-15-20(3)33-21(4)16-23/h15-19,22,24-25H,5-14,31H2,1-4H3,(H,32,34,35)/t19-,24-,25-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497237
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CCOCC1
Show InChI InChI=1S/C28H43N5O3/c1-3-4-19(2)30-28-29-17-24-25(18-33(26(24)31-28)22-5-7-23(34)8-6-22)20-9-13-32(14-10-20)27(35)21-11-15-36-16-12-21/h17-23,34H,3-16H2,1-2H3,(H,29,30,31)/t19-,22-,23-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497269
PNG
((1-(2-fluoroethyl)piperidin- 4-yl)(4-(7-((1R,4S)-4...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CCN(CCF)CC1
Show InChI InChI=1S/C30H47FN6O2/c1-3-4-21(2)33-30-32-19-26-27(20-37(28(26)34-30)24-5-7-25(38)8-6-24)22-11-16-36(17-12-22)29(39)23-9-14-35(15-10-23)18-13-31/h19-25,38H,3-18H2,1-2H3,(H,32,33,34)/t21-,24-,25-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497313
PNG
((1S,4r)-4-(5-(1-((2,6- dimethylpyridin-4- yl)methy...)
Show SMILES C[C@H](Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(Cc2cc(C)nc(C)c2)CC1)c1ccccc1
Show InChI InChI=1S/C33H42N6O/c1-22-17-25(18-23(2)35-22)20-38-15-13-27(14-16-38)31-21-39(28-9-11-29(40)12-10-28)32-30(31)19-34-33(37-32)36-24(3)26-7-5-4-6-8-26/h4-8,17-19,21,24,27-29,40H,9-16,20H2,1-3H3,(H,34,36,37)/t24-,28-,29-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497320
PNG
((1S,4r)-4-(2-(((S)-pentan-2- yl)amino)-5-(pyrrolid...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCNC1
Show InChI InChI=1S/C21H33N5O/c1-3-4-14(2)24-21-23-12-18-19(15-9-10-22-11-15)13-26(20(18)25-21)16-5-7-17(27)8-6-16/h12-17,22,27H,3-11H2,1-2H3,(H,23,24,25)/t14-,15?,16-,17-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497242
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CN(C)C1
Show InChI InChI=1S/C27H42N6O2/c1-4-5-18(2)29-27-28-14-23-24(17-33(25(23)30-27)21-6-8-22(34)9-7-21)19-10-12-32(13-11-19)26(35)20-15-31(3)16-20/h14,17-22,34H,4-13,15-16H2,1-3H3,(H,28,29,30)/t18-,21-,22-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497253
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)[C@@H]1CCCCN1C
Show InChI InChI=1S/C29H46N6O2/c1-4-7-20(2)31-29-30-18-24-25(19-35(27(24)32-29)22-9-11-23(36)12-10-22)21-13-16-34(17-14-21)28(37)26-8-5-6-15-33(26)3/h18-23,26,36H,4-17H2,1-3H3,(H,30,31,32)/t20-,22-,23-,26-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497268
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccnc(C)c1
Show InChI InChI=1S/C29H40N6O2/c1-4-5-19(2)32-29-31-17-25-26(18-35(27(25)33-29)23-6-8-24(36)9-7-23)21-11-14-34(15-12-21)28(37)22-10-13-30-20(3)16-22/h10,13,16-19,21,23-24,36H,4-9,11-12,14-15H2,1-3H3,(H,31,32,33)/t19-,23-,24-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497273
PNG
((1S,4R)-4-(5-(1'-methyl- [1,4'-bipiperidin]-4-yl)-...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C1CCN(C)CC1
Show InChI InChI=1S/C28H46N6O/c1-4-5-20(2)30-28-29-18-25-26(19-34(27(25)31-28)23-6-8-24(35)9-7-23)21-10-16-33(17-11-21)22-12-14-32(3)15-13-22/h18-24,35H,4-17H2,1-3H3,(H,29,30,31)/t20-,23-,24-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497286
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ncccn1
Show InChI InChI=1S/C27H37N7O2/c1-3-5-18(2)31-27-30-16-22-23(17-34(25(22)32-27)20-6-8-21(35)9-7-20)19-10-14-33(15-11-19)26(36)24-28-12-4-13-29-24/h4,12-13,16-21,35H,3,5-11,14-15H2,1-2H3,(H,30,31,32)/t18-,20-,21-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497287
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccncn1
Show InChI InChI=1S/C27H37N7O2/c1-3-4-18(2)31-27-29-15-22-23(16-34(25(22)32-27)20-5-7-21(35)8-6-20)19-10-13-33(14-11-19)26(36)24-9-12-28-17-30-24/h9,12,15-21,35H,3-8,10-11,13-14H2,1-2H3,(H,29,31,32)/t18-,20-,21-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497304
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccc(NC)cc1
Show InChI InChI=1S/C30H42N6O2/c1-4-5-20(2)33-30-32-18-26-27(19-36(28(26)34-30)24-10-12-25(37)13-11-24)21-14-16-35(17-15-21)29(38)22-6-8-23(31-3)9-7-22/h6-9,18-21,24-25,31,37H,4-5,10-17H2,1-3H3,(H,32,33,34)/t20-,24-,25-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497246
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CCN(C)C1
Show InChI InChI=1S/C28H44N6O2/c1-4-5-19(2)30-28-29-16-24-25(18-34(26(24)31-28)22-6-8-23(35)9-7-22)20-11-14-33(15-12-20)27(36)21-10-13-32(3)17-21/h16,18-23,35H,4-15,17H2,1-3H3,(H,29,30,31)/t19-,21?,22-,23-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497254
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)[C@@H]1CCCNC1
Show InChI InChI=1S/C28H44N6O2/c1-3-5-19(2)31-28-30-17-24-25(18-34(26(24)32-28)22-7-9-23(35)10-8-22)20-11-14-33(15-12-20)27(36)21-6-4-13-29-16-21/h17-23,29,35H,3-16H2,1-2H3,(H,30,31,32)/t19-,21+,22-,23-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497255
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)[C@H]1CCCNC1
Show InChI InChI=1S/C28H44N6O2/c1-3-5-19(2)31-28-30-17-24-25(18-34(26(24)32-28)22-7-9-23(35)10-8-22)20-11-14-33(15-12-20)27(36)21-6-4-13-29-16-21/h17-23,29,35H,3-16H2,1-2H3,(H,30,31,32)/t19-,21-,22-,23-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497298
PNG
((4-(2-(((R)-2,3-dihydro-1H- inden-1-yl)amino)-7- (...)
Show SMILES Cc1cc(cc(C)n1)C(=O)N1CCC(CC1)c1cn([C@H]2CC[C@H](O)CC2)c2nc(N[C@@H]3CCc4ccccc34)ncc12
Show InChI InChI=1S/C34H40N6O2/c1-21-17-25(18-22(2)36-21)33(42)39-15-13-24(14-16-39)30-20-40(26-8-10-27(41)11-9-26)32-29(30)19-35-34(38-32)37-31-12-7-23-5-3-4-6-28(23)31/h3-6,17-20,24,26-27,31,41H,7-16H2,1-2H3,(H,35,37,38)/t26-,27-,31-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497306
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccc(CNC)cc1
Show InChI InChI=1S/C31H44N6O2/c1-4-5-21(2)34-31-33-19-27-28(20-37(29(27)35-31)25-10-12-26(38)13-11-25)23-14-16-36(17-15-23)30(39)24-8-6-22(7-9-24)18-32-3/h6-9,19-21,23,25-26,32,38H,4-5,10-18H2,1-3H3,(H,33,34,35)/t21-,25-,26-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497245
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CCNC1
Show InChI InChI=1S/C27H42N6O2/c1-3-4-18(2)30-27-29-16-23-24(17-33(25(23)31-27)21-5-7-22(34)8-6-21)19-10-13-32(14-11-19)26(35)20-9-12-28-15-20/h16-22,28,34H,3-15H2,1-2H3,(H,29,30,31)/t18-,20?,21-,22-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497263
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C29H39N5O2/c1-3-7-20(2)31-29-30-18-25-26(19-34(27(25)32-29)23-10-12-24(35)13-11-23)21-14-16-33(17-15-21)28(36)22-8-5-4-6-9-22/h4-6,8-9,18-21,23-24,35H,3,7,10-17H2,1-2H3,(H,30,31,32)/t20-,23-,24-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497272
PNG
((1S,4R)-4-(5-([1,4'- bipiperidin]-4-yl)-2-(((S)- p...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C1CCNCC1
Show InChI InChI=1S/C27H44N6O/c1-3-4-19(2)30-27-29-17-24-25(18-33(26(24)31-27)22-5-7-23(34)8-6-22)20-11-15-32(16-12-20)21-9-13-28-14-10-21/h17-23,28,34H,3-16H2,1-2H3,(H,29,30,31)/t19-,22-,23-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497276
PNG
((2,6-dimethylpyridin-4- yl)(4-(2-(((1S,2S)-2- ethy...)
Show SMILES CC[C@H]1C[C@@H]1Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1
Show InChI InChI=1S/C30H40N6O2/c1-4-20-15-27(20)33-30-31-16-25-26(17-36(28(25)34-30)23-5-7-24(37)8-6-23)21-9-11-35(12-10-21)29(38)22-13-18(2)32-19(3)14-22/h13-14,16-17,20-21,23-24,27,37H,4-12,15H2,1-3H3,(H,31,33,34)/t20-,23-,24-,27-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497285
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccnnc1
Show InChI InChI=1S/C27H37N7O2/c1-3-4-18(2)31-27-28-16-23-24(17-34(25(23)32-27)21-5-7-22(35)8-6-21)19-10-13-33(14-11-19)26(36)20-9-12-29-30-15-20/h9,12,15-19,21-22,35H,3-8,10-11,13-14H2,1-2H3,(H,28,31,32)/t18-,21-,22-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497296
PNG
((2,6-dimethylpyridin-4- yl)(4-(2-(((S)-1-(4- fluor...)
Show SMILES C[C@H](Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1)c1ccc(F)cc1
Show InChI InChI=1S/C33H39FN6O2/c1-20-16-25(17-21(2)36-20)32(42)39-14-12-24(13-15-39)30-19-40(27-8-10-28(41)11-9-27)31-29(30)18-35-33(38-31)37-22(3)23-4-6-26(34)7-5-23/h4-7,16-19,22,24,27-28,41H,8-15H2,1-3H3,(H,35,37,38)/t22-,27-,28-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497325
PNG
((2,6-dimethylpyridin-4- yl)(4-(7-(((1r,4S)-4- hydr...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn(CC3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1
Show InChI InChI=1S/C31H44N6O2/c1-5-6-20(2)34-31-32-17-27-28(19-37(29(27)35-31)18-23-7-9-26(38)10-8-23)24-11-13-36(14-12-24)30(39)25-15-21(3)33-22(4)16-25/h15-17,19-20,23-24,26,38H,5-14,18H2,1-4H3,(H,32,34,35)/t20-,23?,26-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497228
PNG
((1S,4R)-4-(5-(1-((1- methylpiperidin-4- yl)sulfony...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)S(=O)(=O)C1CCN(C)CC1
Show InChI InChI=1S/C28H46N6O3S/c1-4-5-20(2)30-28-29-18-25-26(19-34(27(25)31-28)22-6-8-23(35)9-7-22)21-10-16-33(17-11-21)38(36,37)24-12-14-32(3)15-13-24/h18-24,35H,4-17H2,1-3H3,(H,29,30,31)/t20-,22-,23-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497230
PNG
((1S,4R)-4-(2-(((S)-pentan- 2-yl)amino)-5-(1- (pipe...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)S(=O)(=O)C1CCNCC1
Show InChI InChI=1S/C27H44N6O3S/c1-3-4-19(2)30-27-29-17-24-25(18-33(26(24)31-27)21-5-7-22(34)8-6-21)20-11-15-32(16-12-20)37(35,36)23-9-13-28-14-10-23/h17-23,28,34H,3-16H2,1-2H3,(H,29,30,31)/t19-,21-,22-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497233
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CCNCC1
Show InChI InChI=1S/C28H44N6O2/c1-3-4-19(2)31-28-30-17-24-25(18-34(26(24)32-28)22-5-7-23(35)8-6-22)20-11-15-33(16-12-20)27(36)21-9-13-29-14-10-21/h17-23,29,35H,3-16H2,1-2H3,(H,30,31,32)/t19-,22-,23-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497241
PNG
(Azetidin-3-yl(4-(7- ((1R,4S)-4- hydroxycyclohexyl)...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CNC1
Show InChI InChI=1S/C26H40N6O2/c1-3-4-17(2)29-26-28-15-22-23(16-32(24(22)30-26)20-5-7-21(33)8-6-20)18-9-11-31(12-10-18)25(34)19-13-27-14-19/h15-21,27,33H,3-14H2,1-2H3,(H,28,29,30)/t17-,20-,21-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497244
PNG
(7-((1R,4S)-4- hydroxycyclohexyl)-5-(1- (methylprol...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CCCN1C
Show InChI InChI=1S/C28H44N6O2/c1-4-6-19(2)30-28-29-17-23-24(18-34(26(23)31-28)21-8-10-22(35)11-9-21)20-12-15-33(16-13-20)27(36)25-7-5-14-32(25)3/h17-22,25,35H,4-16H2,1-3H3,(H,29,30,31)/t19-,21-,22-,25?/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497258
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CCCN(C)C1
Show InChI InChI=1S/C29H46N6O2/c1-4-6-20(2)31-29-30-17-25-26(19-35(27(25)32-29)23-8-10-24(36)11-9-23)21-12-15-34(16-13-21)28(37)22-7-5-14-33(3)18-22/h17,19-24,36H,4-16,18H2,1-3H3,(H,30,31,32)/t20-,22?,23-,24-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497259
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)[C@H]1CCCN(C)C1
Show InChI InChI=1S/C29H46N6O2/c1-4-6-20(2)31-29-30-17-25-26(19-35(27(25)32-29)23-8-10-24(36)11-9-23)21-12-15-34(16-13-21)28(37)22-7-5-14-33(3)18-22/h17,19-24,36H,4-16,18H2,1-3H3,(H,30,31,32)/t20-,22-,23-,24-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497260
PNG
((4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccncc1
Show InChI InChI=1S/C28H38N6O2/c1-3-4-19(2)31-28-30-17-24-25(18-34(26(24)32-28)22-5-7-23(35)8-6-22)20-11-15-33(16-12-20)27(36)21-9-13-29-14-10-21/h9-10,13-14,17-20,22-23,35H,3-8,11-12,15-16H2,1-2H3,(H,30,31,32)/t19-,22-,23-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497267
PNG
((2,6-dimethylpyridin-4- yl)(4-(7-((1R,4S)-4- hydro...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1
Show InChI InChI=1S/C30H42N6O2/c1-5-6-19(2)33-30-31-17-26-27(18-36(28(26)34-30)24-7-9-25(37)10-8-24)22-11-13-35(14-12-22)29(38)23-15-20(3)32-21(4)16-23/h15-19,22,24-25,37H,5-14H2,1-4H3,(H,31,33,34)/t19-,24-,25-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497275
PNG
((1S,4R)-4-(5-(1-((1- methylpiperidin-4- yl)methyl)...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC2CCN(C)CC2)CC1
Show InChI InChI=1S/C29H48N6O/c1-4-5-21(2)31-29-30-18-26-27(20-35(28(26)32-29)24-6-8-25(36)9-7-24)23-12-16-34(17-13-23)19-22-10-14-33(3)15-11-22/h18,20-25,36H,4-17,19H2,1-3H3,(H,30,31,32)/t21-,24-,25-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497288
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cncnc1
Show InChI InChI=1S/C27H37N7O2/c1-3-4-18(2)31-27-30-15-23-24(16-34(25(23)32-27)21-5-7-22(35)8-6-21)19-9-11-33(12-10-19)26(36)20-13-28-17-29-14-20/h13-19,21-22,35H,3-12H2,1-2H3,(H,30,31,32)/t18-,21-,22-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497239
PNG
((1R,4R)-4-(5-((1R,3S,5S)- 8-azabicyclo[3.2.1]octan...)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CC2CCC(C1)N2
Show InChI InChI=1S/C23H35N5O/c1-2-3-10-24-23-25-13-20-21(15-11-16-4-5-17(12-15)26-16)14-28(22(20)27-23)18-6-8-19(29)9-7-18/h13-19,26,29H,2-12H2,1H3,(H,24,25,27)/t15?,16?,17?,18-,19-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497274
PNG
((1S,4R)-4-(2-(((S)-pentan- 2-yl)amino)-5-(1- (pipe...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC2CCNCC2)CC1
Show InChI InChI=1S/C28H46N6O/c1-3-4-20(2)31-28-30-17-25-26(19-34(27(25)32-28)23-5-7-24(35)8-6-23)22-11-15-33(16-12-22)18-21-9-13-29-14-10-21/h17,19-24,29,35H,3-16,18H2,1-2H3,(H,30,31,32)/t20-,23-,24-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497277
PNG
((2,6-dimethylpyridin-4- yl)(4-(2-(((1R,2R)-2- ethy...)
Show SMILES CC[C@@H]1C[C@H]1Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1
Show InChI InChI=1S/C30H40N6O2/c1-4-20-15-27(20)33-30-31-16-25-26(17-36(28(25)34-30)23-5-7-24(37)8-6-23)21-9-11-35(12-10-21)29(38)22-13-18(2)32-19(3)14-22/h13-14,16-17,20-21,23-24,27,37H,4-12,15H2,1-3H3,(H,31,33,34)/t20-,23-,24-,27-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497279
PNG
((4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pent...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cscn1
Show InChI InChI=1S/C26H36N6O2S/c1-3-4-17(2)29-26-27-13-21-22(14-32(24(21)30-26)19-5-7-20(33)8-6-19)18-9-11-31(12-10-18)25(34)23-15-35-16-28-23/h13-20,33H,3-12H2,1-2H3,(H,27,29,30)/t17-,19-,20-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497290
PNG
((2,6-dimethylpyridin-4- yl)(4-(2-((2- ethylbutyl)a...)
Show SMILES CCC(CC)CNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1
Show InChI InChI=1S/C31H44N6O2/c1-5-22(6-2)17-32-31-33-18-27-28(19-37(29(27)35-31)25-7-9-26(38)10-8-25)23-11-13-36(14-12-23)30(39)24-15-20(3)34-21(4)16-24/h15-16,18-19,22-23,25-26,38H,5-14,17H2,1-4H3,(H,32,33,35)/t25-,26-
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497309
PNG
((4- ((dimethylamino)methyl) phenyl)(4-(7-((1r,4S)-...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccc(CN(C)C)cc1
Show InChI InChI=1S/C32H46N6O2/c1-5-6-22(2)34-32-33-19-28-29(21-38(30(28)35-32)26-11-13-27(39)14-12-26)24-15-17-37(18-16-24)31(40)25-9-7-23(8-10-25)20-36(3)4/h7-10,19,21-22,24,26-27,39H,5-6,11-18,20H2,1-4H3,(H,33,34,35)/t22-,26-,27-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
MER intracellular domain/EGFR extracellular domain chimera


(Homo sapiens (Human))
BDBM497316
PNG
((1S,4r)-4-(5-(1- isopropylpiperidin-4-yl)-2- (((S)...)
Show SMILES CC(C)N1CCC(CC1)c1cn([C@H]2CC[C@H](O)CC2)c2nc(N[C@@H](C)c3ccccc3)ncc12
Show InChI InChI=1S/C28H39N5O/c1-19(2)32-15-13-22(14-16-32)26-18-33(23-9-11-24(34)12-10-23)27-25(26)17-29-28(31-27)30-20(3)21-7-5-4-6-8-21/h4-8,17-20,22-24,34H,9-16H2,1-3H3,(H,29,30,31)/t20-,23-,24-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Mer Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3


(Homo sapiens (Human))
BDBM497243
PNG
(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pentan-2...)
Show SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CCCN1
Show InChI InChI=1S/C27H42N6O2/c1-3-5-18(2)30-27-29-16-22-23(17-33(25(22)31-27)20-7-9-21(34)10-8-20)19-11-14-32(15-12-19)26(35)24-6-4-13-28-24/h16-21,24,28,34H,3-15H2,1-2H3,(H,29,30,31)/t18-,20-,21-,24?/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 750n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
Activity Against Tyro3 Tyrosine Kinase.


US Patent US11001586 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%