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Patent code US11001589

Compile Data Set for Download or QSAR
Found 51 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Flap endonuclease 1


(Homo sapiens (Human))
BDBM323045
PNG
((1R,2R)-N-(2-Methyl-4-oxo-4,5,6,7- tetrahydropyraz...)
Show SMILES Cc1cc(n[nH]1)-c1ccc(cc1)C(=O)[C@@H]1CCCC[C@H]1C(=O)Nc1c(C)nn2CCNC(=O)c12
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US Patent
n/an/a 3.90n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM323046
PNG
((1R,2R)-N-(2-Methyl-4-oxo-4,5,6,7- tetrahydropyraz...)
Show SMILES Cc1nn2CCNC(=O)c2c1NC(=O)[C@@H]1CCCC[C@H]1C(=O)c1ccc(cc1)-c1cc[nH]n1
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n/an/a 4.80n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM323023
PNG
((1R,2R)-2-[4-(3-Methyl-1H-pyrazol-5- yl)benzoyl]-N...)
Show SMILES Cc1cc([nH]n1)-c1ccc(cc1)C(=O)[C@@H]1CCCC[C@H]1C(=O)Nc1cnn2CCNC(=O)c12
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US Patent
n/an/a 6.30n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM323041
PNG
((1R,2R)-N-(4-Oxo-4,5,6,7- tetrahydropyrazolo[1,5-a...)
Show SMILES O=C(Nc1cnn2CCNC(=O)c12)[C@@H]1CCCC[C@H]1C(=O)c1ccc(cc1)-c1ccn[nH]1
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n/an/a 8.10n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM323031
PNG
((1R,2R)-N-[5-(Difluoromethyl)-1H- pyrazol-4-yl]-2-...)
Show SMILES Cc1cc(n[nH]1)-c1ccc(cc1)C(=O)[C@@H]1CCCC[C@H]1C(=O)Nc1cn[nH]c1C(F)F
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n/an/a 8.60n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM497366
PNG
((1R,2R or 1S,2S)-2-[2-Fluoro-4-(3-methyl- 1H-pyraz...)
Show SMILES Cc1cc([nH]n1)-c1ccc(C(=O)C2CCCCC2C(=O)Nc2cnn3CCNC(=O)c23)c(F)c1
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n/an/a 9n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM323047
PNG
((1R,2R)-N-[5-(Difluoromethyl)-1H- pyrazol-4-yl]-2-...)
Show SMILES FC(F)c1[nH]ncc1NC(=O)[C@@H]1CCCC[C@H]1C(=O)c1ccc(cc1)-c1cc[nH]n1
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n/an/a 12n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM323033
PNG
((1R,2R)-N-(5-Methyl-4-oxo-4,5,6,7- tetrahydropyraz...)
Show SMILES CN1CCn2ncc(NC(=O)[C@@H]3CCCC[C@H]3C(=O)c3ccc(cc3)-c3cc[nH]n3)c2C1=O
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n/an/a 20n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM497365
PNG
(4-[({(1R,2R or 1S,2S)-2-[2-Fluoro-4-(3- methyl-1H-...)
Show SMILES Cc1cc([nH]n1)-c1ccc(C(=O)C2CCCCC2C(=O)Nc2cn[nH]c2C(N)=O)c(F)c1
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n/an/a 20n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM323032
PNG
((1R,2R)-N-(5-Methyl-4-oxo-4,5,6,7- tetrahydropyraz...)
Show SMILES CN1CCn2ncc(NC(=O)[C@@H]3CCCC[C@H]3C(=O)c3ccc(cc3)-c3cc(C)[nH]n3)c2C1=O
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n/an/a 22n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM497331
PNG
((1R,2R or 1S,2S)-N-(3-Cyano-1-methyl- 1H-pyrazol-4...)
Show SMILES Cc1cc([nH]n1)-c1ccc(cc1)C(=O)[C@H]1CCCC[C@H]1C(=O)Nc1cn(C)nc1C#N
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n/an/a 22n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM497375
PNG
((1R,2R and 1S,2S)-N-(3-Methyl-1,2- thiazol-5-yl)-2...)
Show SMILES Cc1cc(NC(=O)C2CCCCC2C(=O)c2ccc(cc2)-c2ccn[nH]2)sn1
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n/an/a 23n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM323039
PNG
(5-Methyl-4-[({(1R,2R)-2-[4-(3-methyl-1H- pyrazol-5...)
Show SMILES Cc1cc([nH]n1)-c1ccc(cc1)C(=O)[C@@H]1CCCC[C@H]1C(=O)Nc1c(C)[nH]nc1C(N)=O
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n/an/a 24n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM323042
PNG
((1R,2R)-N-[1-Methyl-5- (melhyIsulfamoyl)-1H-pyrazo...)
Show SMILES CNS(=O)(=O)c1c(NC(=O)[C@@H]2CCCC[C@H]2C(=O)c2ccc(cc2)-c2cc(C)n[nH]2)cnn1C
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n/an/a 25n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM497364
PNG
(4-[({(1R,2R or 1S,2S)-2-[2-Fluoro-4-(3- methyl-1H-...)
Show SMILES Cc1cc([nH]n1)-c1ccc(C(=O)C2CCCCC2C(=O)Nc2cnn(C)c2C(N)=O)c(F)c1
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n/an/a 27n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM497345
PNG
((1S,2S or 1R,2R)-N-(5-Cyano-1-methyl- 1H-pyrazol-4...)
Show SMILES Cn1ncc(NC(=O)[C@@H]2CCCC[C@@H]2C(=O)c2ccc(cc2)-c2cc[nH]n2)c1C#N
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n/an/a 28n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM323036
PNG
(1-Ethyl-4-[({(1R,2R)-2-[4-(3-methyl-1H- pyrazol-5-...)
Show SMILES CCn1ncc(NC(=O)[C@@H]2CCCC[C@H]2C(=O)c2ccc(cc2)-c2cc(C)n[nH]2)c1C(N)=O
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n/an/a 29n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM323025
PNG
((1R,2R)-N-[3-(Difluoromethoxy)-1- methyl-1H-pyrazo...)
Show SMILES Cn1cc(NC(=O)[C@@H]2CCCC[C@H]2C(=O)c2ccc(cc2)-c2ccn[nH]2)c(OC(F)F)n1
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n/an/a 30n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM323029
PNG
((1R,2R)-2-[4-(3-Methyl-1H-pyrazol-5- yl)benzoyl]-N...)
Show SMILES Cc1cc([nH]n1)-c1ccc(cc1)C(=O)[C@@H]1CCCC[C@H]1C(=O)Nc1cnn(C)c1S(N)(=O)=O
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n/an/a 33n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM323017
PNG
(1-Methyl-4-[({(1R,2R)-2-[4-(1H-pyrazol- 3-yl)benzo...)
Show SMILES Cn1ncc(NC(=O)[C@@H]2CCCC[C@H]2C(=O)c2ccc(cc2)-c2cc[nH]n2)c1C(N)=O
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ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM323040
PNG
(4-[({(1R,2R)-2-[4-(1H-Pyrazol-5- yl)benzoyl]cycloh...)
Show SMILES NC(=O)c1[nH]ncc1NC(=O)[C@@H]1CCCC[C@H]1C(=O)c1ccc(cc1)-c1ccn[nH]1
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ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM323019
PNG
(1-Methyl-4-[({(1R,2R)-2-[4-(3-methyl-1H- pyrazol-5...)
Show SMILES Cc1cc(n[nH]1)-c1ccc(cc1)C(=O)[C@@H]1CCCC[C@H]1C(=O)Nc1cn(C)nc1C(N)=O
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ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM323018
PNG
(1-Methyl-4-[({(1R,2R)-2-[4-(3-methyl-1H- pyrazol-5...)
Show SMILES Cc1cc([nH]n1)-c1ccc(cc1)C(=O)[C@@H]1CCCC[C@H]1C(=O)Nc1cnn(C)c1C(N)=O
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ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM497361
PNG
(4-[({(1R,2R or 1S,2S)-2-[2-Fluoro-4-(1H- pyrazol-5...)
Show SMILES Cn1ncc(NC(=O)C2CCCCC2C(=O)c2ccc(cc2F)-c2ccn[nH]2)c1C(N)=O
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ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM497338
PNG
((1R,2R or 1S,2S)-N-(3-Cyano-1-methyl- 1H-pyrazol-4...)
Show SMILES Cn1cc(NC(=O)C2CCCCC2C(=O)c2ccc(cc2)-c2cc[nH]n2)c(n1)C#N
PDB
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n/an/a 41n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM497376
PNG
((1R,2R and 1S,1S)-N-(4-Cyano-3-methyl- 1,2-thiazol...)
Show SMILES Cc1nsc(NC(=O)C2CCCCC2C(=O)c2ccc(cc2)-c2ccn[nH]2)c1C#N
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n/an/a 44n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM323024
PNG
(((1R,2R)-N-[1-Methyl-5-(methylsulfonyl)- 1H-pyrazo...)
Show SMILES Cn1ncc(NC(=O)[C@@H]2CCCC[C@H]2C(=O)c2ccc(cc2)-c2ccn[nH]2)c1S(C)(=O)=O
PDB
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n/an/a 45n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM497371
PNG
((1R,2R and 1S,2S)-N-(3-Methyl-1,2- oxazol-5-yl)-2-...)
Show SMILES Cc1cc(NC(=O)C2CCCCC2C(=O)c2ccc(cc2)-c2ccn[nH]2)on1
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n/an/a 46n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM497374
PNG
((1R,2R and 1S,2S)-N-(3-Cyclopropyl- 1,2,4-thiadiaz...)
Show SMILES O=C(Nc1nc(ns1)C1CC1)C1CCCCC1C(=O)c1ccc(cc1)-c1ccn[nH]1
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n/an/a 53n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM497360
PNG
((1R,2R and 1S,2S)-N-(5-Cyclopropyl-1- methyl-1H-1,...)
Show SMILES Cn1nnc(NC(=O)C2CCCCC2C(=O)c2ccc(cc2)-c2ccn[nH]2)c1C1CC1
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n/an/a 54n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM323022
PNG
((1R,2R)-2-[4-(3-Methyl-1H-pyrazol-5- yl)benzoyl]-N...)
Show SMILES Cc1cc([nH]n1)-c1ccc(cc1)C(=O)[C@@H]1CCCC[C@H]1C(=O)Nc1cn[nH]c1
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n/an/a 57n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM323044
PNG
((1R,2R)-N-[5-(Dimethylsulfamoyl)-1- methyl-1H-pyra...)
Show SMILES CN(C)S(=O)(=O)c1c(NC(=O)[C@@H]2CCCC[C@H]2C(=O)c2ccc(cc2)-c2ccn[nH]2)cnn1C
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n/an/a 65n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM497367
PNG
(4-[({(1R,2R or 1S,2S)-2-[2-Fluoro-4-(3- methyl-1H-...)
Show SMILES Cc1cc([nH]n1)-c1ccc(C(=O)C2CCCCC2C(=O)Nc2nonc2C(N)=O)c(F)c1
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n/an/a 70n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM497326
PNG
(1-Methyl-4-[({(1R,2R or 1S,2S)-2-[4-(1H- pyrazol-3...)
Show SMILES Cn1cc(NC(=O)C2CCCCC2C(=O)c2ccc(cc2)-c2cc[nH]n2)c(n1)C(N)=O
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n/an/a 73n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM323027
PNG
((1R,2R)-N-(2,3-Dihydropyrazolo[5,1- b][1,3]oxazol-...)
Show SMILES Cc1cc([nH]n1)-c1ccc(cc1)C(=O)[C@@H]1CCCC[C@H]1C(=O)Nc1cnn2CCOc12
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n/an/a 82n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM497362
PNG
(4-[({(1R,2R or 1S,2S)-2-[2-Fluoro-4-(1H- pyrazol-5...)
Show SMILES Cn1cc(NC(=O)C2CCCCC2C(=O)c2ccc(cc2F)-c2ccn[nH]2)c(n1)C(N)=O
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n/an/a 83n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM497373
PNG
((1R,2R and 1S,2S)-N-(5-Cyano-1-methyl- 1H-pyrazol-...)
Show SMILES Cc1cc([nH]n1)-c1ccc(cc1)C(=O)C1CCCCC1C(=O)Nc1cnn(C)c1C#N
PDB
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n/an/a 86n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM497363
PNG
(4-[({(1R,2R or 1S,2S)-2-[2-Fluoro-4-(3- methyl-1H-...)
Show SMILES Cc1cc([nH]n1)-c1ccc(C(=O)C2CCCCC2C(=O)Nc2cn(C)nc2C(N)=O)c(F)c1
PDB
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n/an/a 90n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM323060
PNG
((1R,2R)-2-[4-(3-Methyl-1H-pyrazol-5- yl)benzoyl]-N...)
Show SMILES Cc1cc([nH]n1)-c1ccc(cc1)C(=O)[C@@H]1CCCC[C@H]1C(=O)Nc1nnco1
PDB
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n/an/a 140n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM497368
PNG
(3-[({(1R,2R or 1S,2S)-2-[2-Fluoro-4-(1H- pyrazol-5...)
Show SMILES Cc1onc(NC(=O)C2CCCCC2C(=O)c2ccc(cc2F)-c2ccn[nH]2)c1C(N)=O
PDB
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n/an/a 160n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM497359
PNG
(4-[({(1R,2R and 1S,2S)-2-[2-Chloro-4-(3- methyl-1H...)
Show SMILES Cc1cc([nH]n1)-c1ccc(C(=O)C2CCCCC2C(=O)Nc2cnn(C)c2C(N)=O)c(Cl)c1
PDB
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n/an/a 170n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM497347
PNG
(N,1-Dimethyl-4-[({(1R,2R and 1S,2S)-2- [4-(1H-pyra...)
Show SMILES CNC(=O)c1nn(C)cc1NC(=O)C1CCCCC1C(=O)c1ccc(cc1)-c1cc[nH]n1
PDB
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n/an/a 180n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM497358
PNG
(4-[({(1R,2R and 1S,2S)-2-[2-Chloro-4- (1H-pyrazol-...)
Show SMILES Cn1ncc(NC(=O)C2CCCCC2C(=O)c2ccc(cc2Cl)-c2ccn[nH]2)c1C(N)=O
PDB
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n/an/a 190n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM497369
PNG
(1-Ethyl-4-[({(1R,2R and 1S,2S)-2-[4-(1H- pyrazol-5...)
Show SMILES CCn1cc(NC(=O)C2CCCCC2C(=O)c2ccc(cc2)-c2ccn[nH]2)c(n1)C(N)=O
PDB
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n/an/a 200n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM497372
PNG
((1R,2R and 1S,2S)-N-(4-Methyl-1,3- oxazol-2-yl)-2-...)
Show SMILES Cc1coc(NC(=O)C2CCCCC2C(=O)c2ccc(cc2)-c2ccn[nH]2)n1
PDB
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n/an/a 210n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM323038
PNG
(N,1-Dimethyl-4-[({(1R,2R)-2-[4-(5- methyl-1H-pyraz...)
Show SMILES CNC(=O)c1c(NC(=O)[C@@H]2CCCC[C@H]2C(=O)c2ccc(cc2)-c2cc(C)[nH]n2)cnn1C
PDB
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n/an/a 230n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM323026
PNG
((1R,2R)-2-[4-(3-Methyl-1H-pyrazol-5- yl)benzoyl]-N...)
Show SMILES Cc1cc([nH]n1)-c1ccc(cc1)C(=O)[C@@H]1CCCC[C@H]1C(=O)Nc1cn(C)nc1S(N)(=O)=O
PDB
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n/an/a 270n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM323043
PNG
((1R,2R)-N-(1-Methyl-3-sulfamoyl-1H- pyrazol-4-yl)-...)
Show SMILES Cn1cc(NC(=O)[C@@H]2CCCC[C@H]2C(=O)c2ccc(cc2)-c2ccn[nH]2)c(n1)S(N)(=O)=O
PDB
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n/an/a 290n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM497340
PNG
((1R,2R and 1S,2S)-N-(5-Methoxy-1- methyl-1H-pyrazo...)
Show SMILES COc1c(NC(=O)C2CCCCC2C(=O)c2ccc(cc2)-c2cc[nH]n2)cnn1C
PDB
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n/an/a 400n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM497330
PNG
((1S,2S or 1R,2R)-N-(3-Cyano-1-methyl- 1H-pyrazol-4...)
Show SMILES Cc1cc([nH]n1)-c1ccc(cc1)C(=O)[C@H]1CCCC[C@@H]1C(=O)Nc1cn(C)nc1C#N
PDB
MMDB

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n/an/a 2.50E+3n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM497344
PNG
((1R,2R or 1S,2S)-N-(5-Cyano-1-methyl- 1H-pyrazol-4...)
Show SMILES Cn1ncc(NC(=O)[C@H]2CCCC[C@@H]2C(=O)c2ccc(cc2)-c2cc[nH]n2)c1C#N
PDB
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n/an/a 3.70E+3n/an/an/an/an/an/a



ASTRAZENECA AB

US Patent


Assay Description
Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...


US Patent US11001589 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%