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Patent code US11008304

Compile Data Set for Download or QSAR
Found 85 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497491
PNG
(US11008304, Example 77)
Show SMILES COc1cc(C)c(cc1C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO)-c1cnn(c1)C1CC1
Show InChI InChI=1S/C24H26N8O3/c1-14-9-21(35-3)19(10-18(14)16-11-25-31(12-16)17-7-8-17)24(34)27-22-6-4-5-20(26-22)23-28-29-30-32(23)15(2)13-33/h4-6,9-12,15,17,33H,7-8,13H2,1-3H3,(H,26,27,34)/t15-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497494
PNG
(US11008304, Example 80)
Show SMILES COc1cc(C)c(cc1C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO)-c1ccn(n1)C(C)C
Show InChI InChI=1S/C24H28N8O3/c1-14(2)31-10-9-19(28-31)17-12-18(21(35-5)11-15(17)3)24(34)26-22-8-6-7-20(25-22)23-27-29-30-32(23)16(4)13-33/h6-12,14,16,33H,13H2,1-5H3,(H,25,26,34)/t16-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497489
PNG
(US11008304, Example 75)
Show SMILES COc1cc(C)c(cc1C(=O)Nc1cccc(n1)-c1nnnn1C(C)C)-c1cnn(c1)C1CC1
Show InChI InChI=1S/C24H26N8O2/c1-14(2)32-23(28-29-30-32)20-6-5-7-22(26-20)27-24(33)19-11-18(15(3)10-21(19)34-4)16-12-25-31(13-16)17-8-9-17/h5-7,10-14,17H,8-9H2,1-4H3,(H,26,27,33)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497490
PNG
(US11008304, Example 76)
Show SMILES COc1cc(C)c(cc1C(=O)Nc1cccc(n1)-n1nnnc1C(C)C)-c1cnn(c1)C1CC1
Show InChI InChI=1S/C24H26N8O2/c1-14(2)23-28-29-30-32(23)22-7-5-6-21(26-22)27-24(33)19-11-18(15(3)10-20(19)34-4)16-12-25-31(13-16)17-8-9-17/h5-7,10-14,17H,8-9H2,1-4H3,(H,26,27,33)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497465
PNG
(US11008304, Example 52)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(-c3cnn(c3)C(C)(C)C)c(C)cc2F)n1
Show InChI InChI=1S/C24H27FN8O/c1-14(2)33-22(29-30-31-33)20-8-7-9-21(27-20)28-23(34)18-11-17(15(3)10-19(18)25)16-12-26-32(13-16)24(4,5)6/h7-14H,1-6H3,(H,27,28,34)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497467
PNG
(US11008304, Example 54)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc(-c3cnn(c3)C(C)(C)C)c(C)cc2F)n1
Show InChI InChI=1S/C24H27FN8O2/c1-14-9-19(25)18(10-17(14)16-11-26-32(12-16)24(3,4)5)23(35)28-21-8-6-7-20(27-21)22-29-30-31-33(22)15(2)13-34/h6-12,15,34H,13H2,1-5H3,(H,27,28,35)/t15-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497433
PNG
(US11008304, Example 20)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(-c3cnn(c3)C(C)(C)C)c(C)cn2)n1
Show InChI InChI=1S/C23H27N9O/c1-14(2)32-21(28-29-30-32)18-8-7-9-20(26-18)27-22(33)19-10-17(15(3)11-24-19)16-12-25-31(13-16)23(4,5)6/h7-14H,1-6H3,(H,26,27,33)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497498
PNG
(US11008304, Example 84)
Show SMILES Cc1cc(F)c(cc1-c1cnn(c1)C1CC1)C(=O)Nc1cccc(n1)-c1nnnn1[C@@H]1CCC[C@@H]1O
Show InChI InChI=1S/C25H25FN8O2/c1-14-10-19(26)18(11-17(14)15-12-27-33(13-15)16-8-9-16)25(36)29-23-7-2-4-20(28-23)24-30-31-32-34(24)21-5-3-6-22(21)35/h2,4,7,10-13,16,21-22,35H,3,5-6,8-9H2,1H3,(H,28,29,36)/t21-,22+/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497426
PNG
(US11008304, Example 13)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc(-c3cnn(c3)C3CC3)c(C)cn2)n1
Show InChI InChI=1S/C22H23N9O2/c1-13-9-23-19(8-17(13)15-10-24-30(11-15)16-6-7-16)22(33)26-20-5-3-4-18(25-20)21-27-28-29-31(21)14(2)12-32/h3-5,8-11,14,16,32H,6-7,12H2,1-2H3,(H,25,26,33)/t14-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497470
PNG
(US11008304, Example 57)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc(-c3cnn(c3)C(F)(F)F)c(C)cc2F)n1
Show InChI InChI=1S/C21H18F4N8O2/c1-11-6-16(22)15(7-14(11)13-8-26-32(9-13)21(23,24)25)20(35)28-18-5-3-4-17(27-18)19-29-30-31-33(19)12(2)10-34/h3-9,12,34H,10H2,1-2H3,(H,27,28,35)/t12-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497487
PNG
(US11008304, Example 73)
Show SMILES COc1cc(C)c(cc1C(=O)Nc1cccc(n1)-c1nnnn1C(C)C)-c1cnn(C)c1
Show InChI InChI=1S/C22H24N8O2/c1-13(2)30-21(26-27-28-30)18-7-6-8-20(24-18)25-22(31)17-10-16(14(3)9-19(17)32-5)15-11-23-29(4)12-15/h6-13H,1-5H3,(H,24,25,31)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497455
PNG
(US11008304, Example 42)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(-c3cnc(s3)C3CC3)c(C)cn2)n1
Show InChI InChI=1S/C22H22N8OS/c1-12(2)30-20(27-28-29-30)16-5-4-6-19(25-16)26-21(31)17-9-15(13(3)10-23-17)18-11-24-22(32-18)14-7-8-14/h4-6,9-12,14H,7-8H2,1-3H3,(H,25,26,31)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497458
PNG
(US11008304, Example 45)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc(-c3ccc(s3)C3CC3)c(C)cn2)n1
Show InChI InChI=1S/C23H23N7O2S/c1-13-11-24-18(10-16(13)20-9-8-19(33-20)15-6-7-15)23(32)26-21-5-3-4-17(25-21)22-27-28-29-30(22)14(2)12-31/h3-5,8-11,14-15,31H,6-7,12H2,1-2H3,(H,25,26,32)/t14-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497460
PNG
(US11008304, Example 47)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc(-c3cnn(c3)C3CC3)c(C)cc2F)n1
Show InChI InChI=1S/C23H23FN8O2/c1-13-8-19(24)18(9-17(13)15-10-25-31(11-15)16-6-7-16)23(34)27-21-5-3-4-20(26-21)22-28-29-30-32(22)14(2)12-33/h3-5,8-11,14,16,33H,6-7,12H2,1-2H3,(H,26,27,34)/t14-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497420
PNG
(US11008304, Example 7)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(-c3cnn(c3)C3CC3)c(cn2)N2CCN(C)CC2)n1
Show InChI InChI=1S/C26H31N11O/c1-17(2)37-25(31-32-33-37)21-5-4-6-24(29-21)30-26(38)22-13-20(18-14-28-36(16-18)19-7-8-19)23(15-27-22)35-11-9-34(3)10-12-35/h4-6,13-17,19H,7-12H2,1-3H3,(H,29,30,38)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497422
PNG
(US11008304, Example 9)
Show SMILES CC(C)n1nnnc1-c1nc(NC(=O)c2cc(-c3cnn(c3)C3CC3)c(cn2)N2CCCC2)cs1
Show InChI InChI=1S/C23H26N10OS/c1-14(2)33-21(28-29-30-33)23-27-20(13-35-23)26-22(34)18-9-17(15-10-25-32(12-15)16-5-6-16)19(11-24-18)31-7-3-4-8-31/h9-14,16H,3-8H2,1-2H3,(H,26,34)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497425
PNG
(US11008304, Example 12)
Show SMILES CC(C)n1nnnc1-c1nc(NC(=O)c2cc(-c3cnn(c3)C3CC3)c(cn2)N2CCN(C)CC2)cs1
Show InChI InChI=1S/C24H29N11OS/c1-15(2)35-22(29-30-31-35)24-28-21(14-37-24)27-23(36)19-10-18(16-11-26-34(13-16)17-4-5-17)20(12-25-19)33-8-6-32(3)7-9-33/h10-15,17H,4-9H2,1-3H3,(H,27,36)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497431
PNG
(US11008304, Example 18)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(-c3cnn(c3)C3CC3)c(cn2)C(F)F)n1
Show InChI InChI=1S/C22H21F2N9O/c1-12(2)33-21(29-30-31-33)17-4-3-5-19(27-17)28-22(34)18-8-15(16(10-25-18)20(23)24)13-9-26-32(11-13)14-6-7-14/h3-5,8-12,14,20H,6-7H2,1-2H3,(H,27,28,34)
PDB

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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497452
PNG
(US11008304, Example 39)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(-c3cnc(C)s3)c(C)cn2)n1
Show InChI InChI=1S/C20H20N8OS/c1-11(2)28-19(25-26-27-28)15-6-5-7-18(23-15)24-20(29)16-8-14(12(3)9-22-16)17-10-21-13(4)30-17/h5-11H,1-4H3,(H,23,24,29)
PDB

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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497459
PNG
(US11008304, Example 46)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(-c3cnn(c3)C3CC3)c(C)cc2F)n1
Show InChI InChI=1S/C23H23FN8O/c1-13(2)32-22(28-29-30-32)20-5-4-6-21(26-20)27-23(33)18-10-17(14(3)9-19(18)24)15-11-25-31(12-15)16-7-8-16/h4-6,9-13,16H,7-8H2,1-3H3,(H,26,27,33)
PDB

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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497466
PNG
(US11008304, Example 53)
Show SMILES CC(C)c1nnnn1-c1cccc(NC(=O)c2cc(-c3cnn(c3)C(C)(C)C)c(C)cc2F)n1
Show InChI InChI=1S/C24H27FN8O/c1-14(2)22-29-30-31-33(22)21-9-7-8-20(27-21)28-23(34)18-11-17(15(3)10-19(18)25)16-12-26-32(13-16)24(4,5)6/h7-14H,1-6H3,(H,27,28,34)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497497
PNG
(US11008304, Example 83)
Show SMILES Cc1cc(F)c(cc1-c1cnn(c1)C1CC1)C(=O)Nc1cccc(n1)-c1nnnn1[C@H]1CCC[C@@H]1O
Show InChI InChI=1S/C25H25FN8O2/c1-14-10-19(26)18(11-17(14)15-12-27-33(13-15)16-8-9-16)25(36)29-23-7-2-4-20(28-23)24-30-31-32-34(24)21-5-3-6-22(21)35/h2,4,7,10-13,16,21-22,35H,3,5-6,8-9H2,1H3,(H,28,29,36)/t21-,22-/m0/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497438
PNG
(US11008304, Example 25)
Show SMILES CC(C)n1cnc(c1)-c1cc(ncc1C)C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO
Show InChI InChI=1S/C22H25N9O2/c1-13(2)30-10-19(24-12-30)16-8-18(23-9-14(16)3)22(33)26-20-7-5-6-17(25-20)21-27-28-29-31(21)15(4)11-32/h5-10,12-13,15,32H,11H2,1-4H3,(H,25,26,33)/t15-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497439
PNG
(US11008304, Example 26)
Show SMILES CC(C)n1cc(cn1)-c1cc(ncc1C)C(=O)Nc1cccc(n1)-c1nnnn1C(C)C
Show InChI InChI=1S/C22H25N9O/c1-13(2)30-12-16(11-24-30)17-9-19(23-10-15(17)5)22(32)26-20-8-6-7-18(25-20)21-27-28-29-31(21)14(3)4/h6-14H,1-5H3,(H,25,26,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497441
PNG
(US11008304, Example 28)
Show SMILES CC(C)n1cc(cn1)-c1cc(ncc1C)C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO
Show InChI InChI=1S/C22H25N9O2/c1-13(2)30-11-16(10-24-30)17-8-19(23-9-14(17)3)22(33)26-20-7-5-6-18(25-20)21-27-28-29-31(21)15(4)12-32/h5-11,13,15,32H,12H2,1-4H3,(H,25,26,33)/t15-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497442
PNG
(US11008304, Example 29)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc(-c3cnn(c3)C3CC3)c(cn2)C(F)F)n1
Show InChI InChI=1S/C22H21F2N9O2/c1-12(11-34)33-21(29-30-31-33)17-3-2-4-19(27-17)28-22(35)18-7-15(16(9-25-18)20(23)24)13-8-26-32(10-13)14-5-6-14/h2-4,7-10,12,14,20,34H,5-6,11H2,1H3,(H,27,28,35)/t12-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497450
PNG
(US11008304, Example 37)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cn2)-c2cccnc2)n1
Show InChI InChI=1S/C21H20N8O/c1-13(2)29-20(26-27-28-29)17-7-4-8-19(24-17)25-21(30)18-10-16(14(3)11-23-18)15-6-5-9-22-12-15/h4-13H,1-3H3,(H,24,25,30)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497479
PNG
(US11008304, Example 65)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cc2F)-c2cccnc2)n1
Show InChI InChI=1S/C22H20FN7O/c1-13(2)30-21(27-28-29-30)19-7-4-8-20(25-19)26-22(31)17-11-16(14(3)10-18(17)23)15-6-5-9-24-12-15/h4-13H,1-3H3,(H,25,26,31)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497484
PNG
(US11008304, Example 70)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc(-c3ccc(s3)C3CC3)c(C)cc2F)n1
Show InChI InChI=1S/C24H23FN6O2S/c1-13-10-18(25)17(11-16(13)21-9-8-20(34-21)15-6-7-15)24(33)27-22-5-3-4-19(26-22)23-28-29-30-31(23)14(2)12-32/h3-5,8-11,14-15,32H,6-7,12H2,1-2H3,(H,26,27,33)/t14-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497419
PNG
(US11008304, Example 6)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(-c3cnn(c3)C3CC3)c(cn2)N2CCOCC2)n1
Show InChI InChI=1S/C25H28N10O2/c1-16(2)35-24(30-31-32-35)20-4-3-5-23(28-20)29-25(36)21-12-19(17-13-27-34(15-17)18-6-7-18)22(14-26-21)33-8-10-37-11-9-33/h3-5,12-16,18H,6-11H2,1-2H3,(H,28,29,36)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497440
PNG
(US11008304, Example 27)
Show SMILES CC(C)c1nnnn1-c1cccc(NC(=O)c2cc(-c3cnn(c3)C(C)C)c(C)cn2)n1
Show InChI InChI=1S/C22H25N9O/c1-13(2)21-27-28-29-31(21)20-8-6-7-19(25-20)26-22(32)18-9-17(15(5)10-23-18)16-11-24-30(12-16)14(3)4/h6-14H,1-5H3,(H,25,26,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497454
PNG
(US11008304, Example 41)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cn2)-c2cccnc2)n1
Show InChI InChI=1S/C21H20N8O2/c1-13-10-23-18(9-16(13)15-5-4-8-22-11-15)21(31)25-19-7-3-6-17(24-19)20-26-27-28-29(20)14(2)12-30/h3-11,14,30H,12H2,1-2H3,(H,24,25,31)/t14-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497492
PNG
(US11008304, Example 78)
Show SMILES COc1cc(C)c(cc1C(=O)Nc1cccc(n1)-c1nnnn1C(C)C)-c1ccn(n1)C(C)C
Show InChI InChI=1S/C24H28N8O2/c1-14(2)31-11-10-19(28-31)17-13-18(21(34-6)12-16(17)5)24(33)26-22-9-7-8-20(25-22)23-27-29-30-32(23)15(3)4/h7-15H,1-6H3,(H,25,26,33)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497496
PNG
(US11008304, Example 82)
Show SMILES Cc1cc(F)c(cc1-c1cnn(c1)C1CC1)C(=O)Nc1cccc(n1)-c1nnnn1[C@@H]1CCOC1
Show InChI InChI=1S/C24H23FN8O2/c1-14-9-20(25)19(10-18(14)15-11-26-32(12-15)16-5-6-16)24(34)28-22-4-2-3-21(27-22)23-29-30-31-33(23)17-7-8-35-13-17/h2-4,9-12,16-17H,5-8,13H2,1H3,(H,27,28,34)/t17-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497423
PNG
(US11008304, Example 10)
Show SMILES CC(C)n1nnnc1-c1nc(NC(=O)c2cc(-c3cnn(c3)C3CC3)c(cn2)N2CCOCC2)cs1
Show InChI InChI=1S/C23H26N10O2S/c1-14(2)33-21(28-29-30-33)23-27-20(13-36-23)26-22(34)18-9-17(15-10-25-32(12-15)16-3-4-16)19(11-24-18)31-5-7-35-8-6-31/h9-14,16H,3-8H2,1-2H3,(H,26,34)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497429
PNG
(US11008304, Example 16)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc(-c3cnn(c3)C3CC3)c(cn2)C(F)(F)F)n1
Show InChI InChI=1S/C22H20F3N9O2/c1-12(11-35)34-20(30-31-32-34)17-3-2-4-19(28-17)29-21(36)18-7-15(16(9-26-18)22(23,24)25)13-8-27-33(10-13)14-5-6-14/h2-4,7-10,12,14,35H,5-6,11H2,1H3,(H,28,29,36)/t12-/m1/s1
PDB

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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497432
PNG
(US11008304, Example 19)
Show SMILES CC(C)n1nnnc1-c1nc(NC(=O)c2cc(-c3cnn(c3)C3CC3)c(cn2)C(F)F)cs1
Show InChI InChI=1S/C20H19F2N9OS/c1-10(2)31-18(27-28-29-31)20-26-16(9-33-20)25-19(32)15-5-13(14(7-23-15)17(21)22)11-6-24-30(8-11)12-3-4-12/h5-10,12,17H,3-4H2,1-2H3,(H,25,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497435
PNG
(US11008304, Example 22)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc(-c3cnn(c3)C(C)(C)C)c(C)cn2)n1
Show InChI InChI=1S/C23H27N9O2/c1-14-10-24-19(9-17(14)16-11-25-31(12-16)23(3,4)5)22(34)27-20-8-6-7-18(26-20)21-28-29-30-32(21)15(2)13-33/h6-12,15,33H,13H2,1-5H3,(H,26,27,34)/t15-/m1/s1
PDB

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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497448
PNG
(US11008304, Example 35)
Show SMILES CC(C)n1ccc(n1)-c1cc(ncc1C)C(=O)Nc1cccc(n1)-c1nnnn1[C@H](C)CO
Show InChI InChI=1S/C22H25N9O2/c1-13(2)30-9-8-17(27-30)16-10-19(23-11-14(16)3)22(33)25-20-7-5-6-18(24-20)21-26-28-29-31(21)15(4)12-32/h5-11,13,15,32H,12H2,1-4H3,(H,24,25,33)/t15-/m1/s1
PDB

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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497461
PNG
(US11008304, Example 48)
Show SMILES CC(C)c1nnnn1-c1cccc(NC(=O)c2cc(-c3cnn(c3)C3CC3)c(C)cc2F)n1
Show InChI InChI=1S/C23H23FN8O/c1-13(2)22-28-29-30-32(22)21-6-4-5-20(26-21)27-23(33)18-10-17(14(3)9-19(18)24)15-11-25-31(12-15)16-7-8-16/h4-6,9-13,16H,7-8H2,1-3H3,(H,26,27,33)
PDB

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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497462
PNG
(US11008304, Example 49)
Show SMILES CC(C)n1cc(cn1)-c1cc(C(=O)Nc2cccc(n2)-c2nnnn2C(C)C)c(F)cc1C
Show InChI InChI=1S/C23H25FN8O/c1-13(2)31-12-16(11-25-31)17-10-18(19(24)9-15(17)5)23(33)27-21-8-6-7-20(26-21)22-28-29-30-32(22)14(3)4/h6-14H,1-5H3,(H,26,27,33)
PDB

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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497488
PNG
(US11008304, Example 74)
Show SMILES COc1cc(C)c(cc1C(=O)Nc1cccc(n1)-n1nnnc1C(C)C)-c1cnn(C)c1
Show InChI InChI=1S/C22H24N8O2/c1-13(2)21-26-27-28-30(21)20-8-6-7-19(24-20)25-22(31)17-10-16(14(3)9-18(17)32-5)15-11-23-29(4)12-15/h6-13H,1-5H3,(H,24,25,31)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497464
PNG
(US11008304, Example 51)
Show SMILES CC(C)c1nnnn1-c1cccc(NC(=O)c2cc(-c3cnn(c3)C(C)C)c(C)cc2F)n1
Show InChI InChI=1S/C23H25FN8O/c1-13(2)22-28-29-30-32(22)21-8-6-7-20(26-21)27-23(33)18-10-17(15(5)9-19(18)24)16-11-25-31(12-16)14(3)4/h6-14H,1-5H3,(H,26,27,33)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497463
PNG
(US11008304, Example 50)
Show SMILES CC(C)n1cc(cn1)-c1cc(C(=O)Nc2cccc(n2)-c2nnnn2[C@H](C)CO)c(F)cc1C
Show InChI InChI=1S/C23H25FN8O2/c1-13(2)31-11-16(10-25-31)17-9-18(19(24)8-14(17)3)23(34)27-21-7-5-6-20(26-21)22-28-29-30-32(22)15(4)12-33/h5-11,13,15,33H,12H2,1-4H3,(H,26,27,34)/t15-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497495
PNG
(US11008304, Example 81)
Show SMILES Cc1cc(F)c(cc1-c1cnn(c1)C1CC1)C(=O)Nc1cccc(n1)-c1nnnn1[C@H]1CCOC1
Show InChI InChI=1S/C24H23FN8O2/c1-14-9-20(25)19(10-18(14)15-11-26-32(12-15)16-5-6-16)24(34)28-22-4-2-3-21(27-22)23-29-30-31-33(23)17-7-8-35-13-17/h2-4,9-12,16-17H,5-8,13H2,1H3,(H,27,28,34)/t17-/m0/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497445
PNG
(US11008304, Example 32)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc(-c3cnn(c3)C(F)(F)F)c(C)cn2)n1
Show InChI InChI=1S/C20H18F3N9O2/c1-11-7-24-16(6-14(11)13-8-25-31(9-13)20(21,22)23)19(34)27-17-5-3-4-15(26-17)18-28-29-30-32(18)12(2)10-33/h3-9,12,33H,10H2,1-2H3,(H,26,27,34)/t12-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497456
PNG
(US11008304, Example 43)
Show SMILES C[C@H](CO)n1nnnc1-c1cccc(NC(=O)c2cc(-c3cnc(s3)C3CC3)c(C)cn2)n1
Show InChI InChI=1S/C22H22N8O2S/c1-12-9-23-17(8-15(12)18-10-24-22(33-18)14-6-7-14)21(32)26-19-5-3-4-16(25-19)20-27-28-29-30(20)13(2)11-31/h3-5,8-10,13-14,31H,6-7,11H2,1-2H3,(H,25,26,32)/t13-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497414
PNG
(US11008304, Example 1)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(ccn2)-c2cnn(c2)C2CC2)n1
Show InChI InChI=1S/C21H21N9O/c1-13(2)30-20(26-27-28-30)17-4-3-5-19(24-17)25-21(31)18-10-14(8-9-22-18)15-11-23-29(12-15)16-6-7-16/h3-5,8-13,16H,6-7H2,1-2H3,(H,24,25,31)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497418
PNG
(US11008304, Example 5)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(-c3cnn(c3)C3CC3)c(cn2)N2CCCCC2)n1
Show InChI InChI=1S/C26H30N10O/c1-17(2)36-25(31-32-33-36)21-7-6-8-24(29-21)30-26(37)22-13-20(18-14-28-35(16-18)19-9-10-19)23(15-27-22)34-11-4-3-5-12-34/h6-8,13-17,19H,3-5,9-12H2,1-2H3,(H,29,30,37)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497457
PNG
(US11008304, Example 44)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(-c3ccc(s3)C3CC3)c(C)cn2)n1
Show InChI InChI=1S/C23H23N7OS/c1-13(2)30-22(27-28-29-30)17-5-4-6-21(25-17)26-23(31)18-11-16(14(3)12-24-18)20-10-9-19(32-20)15-7-8-15/h4-6,9-13,15H,7-8H2,1-3H3,(H,25,26,31)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497468
PNG
(US11008304, Example 55)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(-c3cnn(c3)C(F)(F)F)c(C)cc2F)n1
Show InChI InChI=1S/C21H18F4N8O/c1-11(2)33-19(29-30-31-33)17-5-4-6-18(27-17)28-20(34)15-8-14(12(3)7-16(15)22)13-9-26-32(10-13)21(23,24)25/h4-11H,1-3H3,(H,27,28,34)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497475
PNG
(US11008304, Example 61)
Show SMILES CC(C)n1cnc(c1)-c1cc(C(=O)Nc2cccc(n2)-c2nnnn2C(C)C)c(F)cc1C
Show InChI InChI=1S/C23H25FN8O/c1-13(2)31-11-20(25-12-31)16-10-17(18(24)9-15(16)5)23(33)27-21-8-6-7-19(26-21)22-28-29-30-32(22)14(3)4/h6-14H,1-5H3,(H,26,27,33)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497493
PNG
(US11008304, Example 79)
Show SMILES COc1cc(C)c(cc1C(=O)Nc1cccc(n1)-n1nnnc1C(C)C)-c1ccn(n1)C(C)C
Show InChI InChI=1S/C24H28N8O2/c1-14(2)23-27-29-30-32(23)22-9-7-8-21(25-22)26-24(33)18-13-17(16(5)12-20(18)34-6)19-10-11-31(28-19)15(3)4/h7-15H,1-6H3,(H,25,26,33)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497415
PNG
(US11008304, Example 2)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(-c3cnn(c3)C3CC3)c(C)cn2)n1
Show InChI InChI=1S/C22H23N9O/c1-13(2)31-21(27-28-29-31)18-5-4-6-20(25-18)26-22(32)19-9-17(14(3)10-23-19)15-11-24-30(12-15)16-7-8-16/h4-6,9-13,16H,7-8H2,1-3H3,(H,25,26,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497428
PNG
(US11008304, Example 15)
Show SMILES CC(C)n1nnnc1-c1nc(NC(=O)c2cc(-c3cnn(c3)C3CC3)c(cn2)C(F)(F)F)cs1
Show InChI InChI=1S/C20H18F3N9OS/c1-10(2)32-17(28-29-30-32)19-27-16(9-34-19)26-18(33)15-5-13(14(7-24-15)20(21,22)23)11-6-25-31(8-11)12-3-4-12/h5-10,12H,3-4H2,1-2H3,(H,26,33)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497446
PNG
(US11008304, Example 33)
Show SMILES CC(C)n1ccc(n1)-c1cc(ncc1C)C(=O)Nc1cccc(n1)-c1nnnn1C(C)C
Show InChI InChI=1S/C22H25N9O/c1-13(2)30-10-9-17(27-30)16-11-19(23-12-15(16)5)22(32)25-20-8-6-7-18(24-20)21-26-28-29-31(21)14(3)4/h6-14H,1-5H3,(H,24,25,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497424
PNG
(US11008304, Example 11)
Show SMILES CC(C)n1nnnc1-c1nc(NC(=O)c2cc(-c3cnn(c3)C3CC3)c(cn2)N2CCCCC2)cs1
Show InChI InChI=1S/C24H28N10OS/c1-15(2)34-22(29-30-31-34)24-28-21(14-36-24)27-23(35)19-10-18(16-11-26-33(13-16)17-6-7-17)20(12-25-19)32-8-4-3-5-9-32/h10-15,17H,3-9H2,1-2H3,(H,27,35)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497427
PNG
(US11008304, Example 14)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(-c3cnn(c3)C3CC3)c(cn2)C(F)(F)F)n1
Show InChI InChI=1S/C22H20F3N9O/c1-12(2)34-20(30-31-32-34)17-4-3-5-19(28-17)29-21(35)18-8-15(16(10-26-18)22(23,24)25)13-9-27-33(11-13)14-6-7-14/h3-5,8-12,14H,6-7H2,1-2H3,(H,28,29,35)
PDB

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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497481
PNG
(US11008304, Example 67)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(-c3cnc(C)s3)c(C)cc2F)n1
Show InChI InChI=1S/C21H20FN7OS/c1-11(2)29-20(26-27-28-29)17-6-5-7-19(24-17)25-21(30)15-9-14(12(3)8-16(15)22)18-10-23-13(4)31-18/h5-11H,1-4H3,(H,24,25,30)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497436
PNG
(US11008304, Example 23)
Show SMILES CC(C)n1cnc(c1)-c1cc(ncc1C)C(=O)Nc1cccc(n1)-c1nnnn1C(C)C
Show InChI InChI=1S/C22H25N9O/c1-13(2)30-11-19(24-12-30)16-9-18(23-10-15(16)5)22(32)26-20-8-6-7-17(25-20)21-27-28-29-31(21)14(3)4/h6-14H,1-5H3,(H,25,26,32)
PDB

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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497474
PNG
(US11008304, Example 60)
Show SMILES CC(C)n1ccc(n1)-c1cc(C(=O)Nc2cccc(n2)-c2nnnn2[C@H](C)CO)c(F)cc1C
Show InChI InChI=1S/C23H25FN8O2/c1-13(2)31-9-8-19(28-31)16-11-17(18(24)10-14(16)3)23(34)26-21-7-5-6-20(25-21)22-27-29-30-32(22)15(4)12-33/h5-11,13,15,33H,12H2,1-4H3,(H,25,26,34)/t15-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497416
PNG
(US11008304, Example 3)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(-c3cnn(c3)C3CC3)c(F)cn2)n1
Show InChI InChI=1S/C21H20FN9O/c1-12(2)31-20(27-28-29-31)17-4-3-5-19(25-17)26-21(32)18-8-15(16(22)10-23-18)13-9-24-30(11-13)14-6-7-14/h3-5,8-12,14H,6-7H2,1-2H3,(H,25,26,32)
PDB

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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497421
PNG
(US11008304, Example 8)
Show SMILES CC(C)n1nnnc1-c1nc(NC(=O)c2cc(-c3cnn(c3)C3CC3)c(F)cn2)cs1
Show InChI InChI=1S/C19H18FN9OS/c1-10(2)29-17(25-26-27-29)19-24-16(9-31-19)23-18(30)15-5-13(14(20)7-21-15)11-6-22-28(8-11)12-3-4-12/h5-10,12H,3-4H2,1-2H3,(H,23,30)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497453
PNG
(US11008304, Example 40)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(-c3csc(C)n3)c(C)cn2)n1
Show InChI InChI=1S/C20H20N8OS/c1-11(2)28-19(25-26-27-28)15-6-5-7-18(23-15)24-20(29)16-8-14(12(3)9-21-16)17-10-30-13(4)22-17/h5-11H,1-4H3,(H,23,24,29)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497472
PNG
(US11008304, Example 58)
Show SMILES CC(C)n1ccc(n1)-c1cc(C(=O)Nc2cccc(n2)-c2nnnn2C(C)C)c(F)cc1C
Show InChI InChI=1S/C23H25FN8O/c1-13(2)31-10-9-19(28-31)16-12-17(18(24)11-15(16)5)23(33)26-21-8-6-7-20(25-21)22-27-29-30-32(22)14(3)4/h6-14H,1-5H3,(H,25,26,33)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497480
PNG
(US11008304, Example 66)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cc2F)-c2ccncc2)n1
Show InChI InChI=1S/C22H20FN7O/c1-13(2)30-21(27-28-29-30)19-5-4-6-20(25-19)26-22(31)17-12-16(14(3)11-18(17)23)15-7-9-24-10-8-15/h4-13H,1-3H3,(H,25,26,31)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497485
PNG
(US11008304, Example 71)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(-c3cc(on3)C3CC3)c(C)cc2F)n1
Show InChI InChI=1S/C23H22FN7O2/c1-12(2)31-22(27-29-30-31)18-5-4-6-21(25-18)26-23(32)16-10-15(13(3)9-17(16)24)19-11-20(33-28-19)14-7-8-14/h4-6,9-12,14H,7-8H2,1-3H3,(H,25,26,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497486
PNG
(US11008304, Example 72A)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(-c3cc(on3)C3CC3)c(C)cn2)n1
Show InChI InChI=1S/C22H22N8O2/c1-12(2)30-21(26-28-29-30)16-5-4-6-20(24-16)25-22(31)18-9-15(13(3)11-23-18)17-10-19(32-27-17)14-7-8-14/h4-6,9-12,14H,7-8H2,1-3H3,(H,24,25,31)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497430
PNG
(US11008304, Example 17)
Show SMILES CC(C)c1nnnn1-c1cccc(NC(=O)c2cc(-c3cnn(c3)C3CC3)c(C)cn2)n1
Show InChI InChI=1S/C22H23N9O/c1-13(2)21-27-28-29-31(21)20-6-4-5-19(25-20)26-22(32)18-9-17(14(3)10-23-18)15-11-24-30(12-15)16-7-8-16/h4-6,9-13,16H,7-8H2,1-3H3,(H,25,26,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497434
PNG
(US11008304, Example 21)
Show SMILES CC(C)c1nnnn1-c1cccc(NC(=O)c2cc(-c3cnn(c3)C(C)(C)C)c(C)cn2)n1
Show InChI InChI=1S/C23H27N9O/c1-14(2)21-28-29-30-32(21)20-9-7-8-19(26-20)27-22(33)18-10-17(15(3)11-24-18)16-12-25-31(13-16)23(4,5)6/h7-14H,1-6H3,(H,26,27,33)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497443
PNG
(US11008304, Example 30)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(-c3cnn(c3)C(F)(F)F)c(C)cn2)n1
Show InChI InChI=1S/C20H18F3N9O/c1-11(2)32-18(28-29-30-32)15-5-4-6-17(26-15)27-19(33)16-7-14(12(3)8-24-16)13-9-25-31(10-13)20(21,22)23/h4-11H,1-3H3,(H,26,27,33)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497477
PNG
(US11008304, Example 63)
Show SMILES CC(C)n1cnc(c1)-c1cc(C(=O)Nc2cccc(n2)-c2nnnn2[C@H](C)CO)c(F)cc1C
Show InChI InChI=1S/C23H25FN8O2/c1-13(2)31-10-20(25-12-31)16-9-17(18(24)8-14(16)3)23(34)27-21-7-5-6-19(26-21)22-28-29-30-32(22)15(4)11-33/h5-10,12-13,15,33H,11H2,1-4H3,(H,26,27,34)/t15-/m1/s1
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497483
PNG
(US11008304, Example 69)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(-c3ccc(s3)C3CC3)c(C)cc2F)n1
Show InChI InChI=1S/C24H23FN6OS/c1-13(2)31-23(28-29-30-31)19-5-4-6-22(26-19)27-24(32)17-12-16(14(3)11-18(17)25)21-10-9-20(33-21)15-7-8-15/h4-6,9-13,15H,7-8H2,1-3H3,(H,26,27,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497417
PNG
(US11008304, Example 4)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(-c3cnn(c3)C3CC3)c(cn2)N2CCCC2)n1
Show InChI InChI=1S/C25H28N10O/c1-16(2)35-24(30-31-32-35)20-6-5-7-23(28-20)29-25(36)21-12-19(17-13-27-34(15-17)18-8-9-18)22(14-26-21)33-10-3-4-11-33/h5-7,12-16,18H,3-4,8-11H2,1-2H3,(H,28,29,36)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497449
PNG
(US11008304, Example 36)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cn2)-c2ccccn2)n1
Show InChI InChI=1S/C21H20N8O/c1-13(2)29-20(26-27-28-29)17-8-6-9-19(24-17)25-21(30)18-11-15(14(3)12-23-18)16-7-4-5-10-22-16/h4-13H,1-3H3,(H,24,25,30)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497451
PNG
(US11008304, Example 38)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cn2)-c2ccncc2)n1
Show InChI InChI=1S/C21H20N8O/c1-13(2)29-20(26-27-28-29)17-5-4-6-19(24-17)25-21(30)18-11-16(14(3)12-23-18)15-7-9-22-10-8-15/h4-13H,1-3H3,(H,24,25,30)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497499
PNG
(US11008304, Example 72B)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(-c3cc(no3)C3CC3)c(C)cn2)n1
Show InChI InChI=1S/C22H22N8O2/c1-12(2)30-21(26-28-29-30)16-5-4-6-20(24-16)25-22(31)18-9-15(13(3)11-23-18)19-10-17(27-32-19)14-7-8-14/h4-6,9-12,14H,7-8H2,1-3H3,(H,24,25,31)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497469
PNG
(US11008304, Example 56)
Show SMILES CC(C)c1nnnn1-c1cccc(NC(=O)c2cc(-c3cnn(c3)C(F)(F)F)c(C)cc2F)n1
Show InChI InChI=1S/C21H18F4N8O/c1-11(2)19-29-30-31-33(19)18-6-4-5-17(27-18)28-20(34)15-8-14(12(3)7-16(15)22)13-9-26-32(10-13)21(23,24)25/h4-11H,1-3H3,(H,27,28,34)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497478
PNG
(US11008304, Example 64)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(c(C)cc2F)-c2ccccn2)n1
Show InChI InChI=1S/C22H20FN7O/c1-13(2)30-21(27-28-29-30)19-8-6-9-20(25-19)26-22(31)16-12-15(14(3)11-17(16)23)18-7-4-5-10-24-18/h4-13H,1-3H3,(H,25,26,31)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497482
PNG
(US11008304, Example 68)
Show SMILES CC(C)n1nnnc1-c1cccc(NC(=O)c2cc(-c3csc(C)n3)c(C)cc2F)n1
Show InChI InChI=1S/C21H20FN7OS/c1-11(2)29-20(26-27-28-29)17-6-5-7-19(24-17)25-21(30)15-9-14(12(3)8-16(15)22)18-10-31-13(4)23-18/h5-11H,1-4H3,(H,24,25,30)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497447
PNG
(US11008304, Example 34)
Show SMILES CC(C)c1nnnn1-c1cccc(NC(=O)c2cc(-c3ccn(n3)C(C)C)c(C)cn2)n1
Show InChI InChI=1S/C22H25N9O/c1-13(2)21-26-28-29-31(21)20-8-6-7-19(24-20)25-22(32)18-11-16(15(5)12-23-18)17-9-10-30(27-17)14(3)4/h6-14H,1-5H3,(H,24,25,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497444
PNG
(US11008304, Example 31)
Show SMILES CC(C)c1nnnn1-c1cccc(NC(=O)c2cc(-c3cnn(c3)C(F)(F)F)c(C)cn2)n1
Show InChI InChI=1S/C20H18F3N9O/c1-11(2)18-28-29-30-32(18)17-6-4-5-16(26-17)27-19(33)15-7-14(12(3)8-24-15)13-9-25-31(10-13)20(21,22)23/h4-11H,1-3H3,(H,26,27,33)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497437
PNG
(US11008304, Example 24)
Show SMILES CC(C)c1nnnn1-c1cccc(NC(=O)c2cc(-c3cn(cn3)C(C)C)c(C)cn2)n1
Show InChI InChI=1S/C22H25N9O/c1-13(2)21-27-28-29-31(21)20-8-6-7-19(25-20)26-22(32)17-9-16(15(5)10-23-17)18-11-30(12-24-18)14(3)4/h6-14H,1-5H3,(H,25,26,32)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497476
PNG
(US11008304, Example 62)
Show SMILES CC(C)c1nnnn1-c1cccc(NC(=O)c2cc(-c3cn(cn3)C(C)C)c(C)cc2F)n1
Show InChI InChI=1S/C23H25FN8O/c1-13(2)22-28-29-30-32(22)21-8-6-7-20(26-21)27-23(33)17-10-16(15(5)9-18(17)24)19-11-31(12-25-19)14(3)4/h6-14H,1-5H3,(H,26,27,33)
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Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM497473
PNG
(US11008304, Example 59)
Show SMILES CC(C)c1nnnn1-c1cccc(NC(=O)c2cc(-c3ccn(n3)C(C)C)c(C)cc2F)n1
Show InChI InChI=1S/C23H25FN8O/c1-13(2)22-27-29-30-32(22)21-8-6-7-20(25-21)26-23(33)17-12-16(15(5)11-18(17)24)19-9-10-31(28-19)14(3)4/h6-14H,1-5H3,(H,25,26,33)
PDB

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KEGG

UniProtKB/SwissProt

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US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Enanta Pharmaceuticals, Inc.

US Patent


Assay Description
The ability (IC50) of compounds to inhibit ASK1 kinase activity was determined by HTRF® KinEASE™ Assay System. ASK1 was purchased from Thermofisher (...


US Patent US11008304 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%