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Patent code US11008308

Compile Data Set for Download or QSAR

Found 435 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434086
PNG
(US10562891, Example 8 | US11008308, Example 8)
Show SMILES Cc1ccc(F)c2c1nc(CSC1CCOCC1)[nH]c2=O
Show InChI InChI=1S/C15H17FN2O2S/c1-9-2-3-11(16)13-14(9)17-12(18-15(13)19)8-21-10-4-6-20-7-5-10/h2-3,10H,4-8H2,1H3,(H,17,18,19)
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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434100
PNG
(US10562891, Example 22 | US11008308, Example 22)
Show SMILES Cc1cccc2c1nc(CSC1CCC(O)CC1)[nH]c2=O
Show InChI InChI=1S/C16H20N2O2S/c1-10-3-2-4-13-15(10)17-14(18-16(13)20)9-21-12-7-5-11(19)6-8-12/h2-4,11-12,19H,5-9H2,1H3,(H,17,18,20)
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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434112
PNG
(US10562891, Example 34 | US11008308, Example 34)
Show SMILES Cc1ccc(Cl)c2c1nc(CSC1CCOCC1)[nH]c2=O
Show InChI InChI=1S/C15H17ClN2O2S/c1-9-2-3-11(16)13-14(9)17-12(18-15(13)19)8-21-10-4-6-20-7-5-10/h2-3,10H,4-8H2,1H3,(H,17,18,19)
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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM497555
PNG
(US11008308, Example 57)
Show SMILES Cc1ccc(F)c2c1nc(CS[C@H]1CC[C@H](O)CC1)[nH]c2=O
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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434138
PNG
(US10562891, Example 60 | US11008308, Example 61)
Show SMILES Cc1ccc(c2c1nc(CS[C@@H]1CC[C@H](O)CC1)[nH]c2=O)C(F)(F)F
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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434172
PNG
(US10562891, Example 94 | US11008308, Example 94)
Show SMILES O=c1[nH]c(CSC2CCOCC2)nc2cc(Nc3ccon3)ccc12
Show InChI InChI=1S/C17H18N4O3S/c22-17-13-2-1-11(18-15-5-8-24-21-15)9-14(13)19-16(20-17)10-25-12-3-6-23-7-4-12/h1-2,5,8-9,12H,3-4,6-7,10H2,(H,18,21)(H,19,20,22)
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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434179
PNG
(US10562891, Example 101 | US11008308, Example 101)
Show SMILES O[C@H]1CC[C@@H](CC1)SCc1nc2cc(Nc3cccnc3)ccc2c(=O)[nH]1
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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434224
PNG
(US10562891, Example 146 | US11008308, Example 146)
Show SMILES Cc1cccnc1CN1CCC(CC1)SCc1nc2c(C)cccc2c(=O)[nH]1
Show InChI InChI=1S/C22H26N4OS/c1-15-6-4-10-23-19(15)13-26-11-8-17(9-12-26)28-14-20-24-21-16(2)5-3-7-18(21)22(27)25-20/h3-7,10,17H,8-9,11-14H2,1-2H3,(H,24,25,27)
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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434225
PNG
(US10562891, Example 147 | US11008308, Example 147)
Show SMILES Cc1cccc2c1nc(CSC1CCN(CCc3ccccc3)CC1)[nH]c2=O
Show InChI InChI=1S/C23H27N3OS/c1-17-6-5-9-20-22(17)24-21(25-23(20)27)16-28-19-11-14-26(15-12-19)13-10-18-7-3-2-4-8-18/h2-9,19H,10-16H2,1H3,(H,24,25,27)
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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434233
PNG
(US10562891, Example 155 | US11008308, Example 155)
Show SMILES Cc1cccc2c1nc(CSC1CCN(Cc3ccccc3OCC#N)CC1)[nH]c2=O
Show InChI InChI=1S/C24H26N4O2S/c1-17-5-4-7-20-23(17)26-22(27-24(20)29)16-31-19-9-12-28(13-10-19)15-18-6-2-3-8-21(18)30-14-11-25/h2-8,19H,9-10,12-16H2,1H3,(H,26,27,29)
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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434248
PNG
(US10562891, Example 170 | US11008308, Example 170)
Show SMILES Cc1cccc2c1nc(CSC1CCN(CC1)C(=O)[C@@H](N)CCCNC(N)=N)[nH]c2=O
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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434268
PNG
(US10562891, Example 190 | US11008308, Example 190)
Show SMILES O=c1[nH]c(CSC2CCCNCC2)nc2cc(NC3CCCC3)ccc12
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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434288
PNG
(US10562891, Example 210 | US10562891, Example 211a...)
Show SMILES F[C@H]1CNCC[C@@H]1SCc1nc2cc(NC3CCCC3)cc(F)c2c(=O)[nH]1
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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434291
PNG
(US10562891, Example 212 | US11008308, Example 213b)
Show SMILES F[C@@H]1CNCC[C@@H]1SCc1nc2cc(NC3CCCC3)cc(F)c2c(=O)[nH]1
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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434303
PNG
(US10562891, Example 223 | US11008308, Example 223)
Show SMILES F[C@@H]1CNC[C@@H]1SCc1nc2cc(NC3CCCC3)cc(F)c2c(=O)[nH]1
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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434318
PNG
(US10562891, Example 238 | US11008308, Example 238)
Show SMILES Fc1cc(OCC2CCOC2)cc2nc(CSC3CCOCC3)[nH]c(=O)c12
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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434328
PNG
(US10562891, Example 247 | US11008308, Example 247)
Show SMILES Fc1cc(NC2CCCCC2)cc2nc(CSC3CCOCC3)[nH]c(=O)c12
Show InChI InChI=1S/C20H26FN3O2S/c21-16-10-14(22-13-4-2-1-3-5-13)11-17-19(16)20(25)24-18(23-17)12-27-15-6-8-26-9-7-15/h10-11,13,15,22H,1-9,12H2,(H,23,24,25)
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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434331
PNG
(US10562891, Example 250 | US11008308, Example 250)
Show SMILES CS(=O)(=O)N1CCC[C@H](C1)Nc1cc(F)c2c(c1)nc(CSC1CCOCC1)[nH]c2=O
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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434332
PNG
(US10562891, Example 251 | US11008308, Example 251)
Show SMILES Fc1cc(NC2CCC2)cc2nc(CSC3CCOCC3)[nH]c(=O)c12
Show InChI InChI=1S/C18H22FN3O2S/c19-14-8-12(20-11-2-1-3-11)9-15-17(14)18(23)22-16(21-15)10-25-13-4-6-24-7-5-13/h8-9,11,13,20H,1-7,10H2,(H,21,22,23)
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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434347
PNG
(US10562891, Example 266 | US11008308, Example 266)
Show SMILES Fc1cc(NC2CCC(F)(F)C2)cc2nc(CSC3CCNCC3)[nH]c(=O)c12
PDB

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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434356
PNG
(US10562891, Example 275 | US11008308, Example 275)
Show SMILES O=c1[nH]c(CSC2CCNCC2)nc2cc(OCC3CC3)ccc12
Show InChI InChI=1S/C18H23N3O2S/c22-18-15-4-3-13(23-10-12-1-2-12)9-16(15)20-17(21-18)11-24-14-5-7-19-8-6-14/h3-4,9,12,14,19H,1-2,5-8,10-11H2,(H,20,21,22)
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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434361
PNG
(US10562891, Example 280 | US11008308, Example 280)
Show SMILES Fc1cc(OCC2CCC2)cc2nc(CSC3CCNCC3)[nH]c(=O)c12
Show InChI InChI=1S/C19H24FN3O2S/c20-15-8-13(25-10-12-2-1-3-12)9-16-18(15)19(24)23-17(22-16)11-26-14-4-6-21-7-5-14/h8-9,12,14,21H,1-7,10-11H2,(H,22,23,24)
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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434377
PNG
(US10562891, Example 296 | US11008308, Example 296)
Show SMILES Fc1cc2c(cc1NCC1CCC1)nc(CSC1CCS(=O)(=O)CC1)[nH]c2=O
Show InChI InChI=1S/C19H24FN3O3S2/c20-15-8-14-16(9-17(15)21-10-12-2-1-3-12)22-18(23-19(14)24)11-27-13-4-6-28(25,26)7-5-13/h8-9,12-13,21H,1-7,10-11H2,(H,22,23,24)
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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434384
PNG
(US10562891, Example 303 | US11008308, Example 303)
Show SMILES F[C@@H]1CNCC[C@@H]1SCc1nc2cc(NCC3CCC3)c(F)cc2c(=O)[nH]1
PDB

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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM497830
PNG
(US11008308, Example 321a | US11008308, Example 321...)
Show SMILES Fc1cc(OC[C@H]2CCCO2)cc2nc(CSC3CCOCC3)[nH]c(=O)c12
PDB

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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM497833
PNG
(US11008308, Example 323a | US11008308, Example 323...)
Show SMILES Fc1c(F)c2c(cc1NC[C@@H]1CCOC1)nc(CSC1CCOCC1)[nH]c2=O
PDB

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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434413
PNG
(US10562891, Example 328 | US11008308, Example 328)
Show SMILES CO[C@@H]1C[C@@H](C1)Nc1cc2nc(CSC3CCOCC3)[nH]c(=O)c2c(F)c1F
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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM497852
PNG
(US11008308, Example 337)
Show SMILES Fc1c(F)c2c(cc1NCC1CCC1)nc(CSC1CCOCC1)[nH]c2=O
Show InChI InChI=1S/C19H23F2N3O2S/c20-17-14(22-9-11-2-1-3-11)8-13-16(18(17)21)19(25)24-15(23-13)10-27-12-4-6-26-7-5-12/h8,11-12,22H,1-7,9-10H2,(H,23,24,25)
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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434427
PNG
(US10562891, Example 341 | US11008308, Example 341)
Show SMILES O[C@H]1CC[C@@H](CC1)SCc1nc2cc(N[C@@H]3CCC[C@@H]3F)cc(F)c2c(=O)[nH]1
PDB

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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434428
PNG
(US10562891, Example 342 | US11008308, Example 342)
Show SMILES O[C@H]1CC[C@@H](CC1)SCc1nc2cc(OCC3CCOCC3)cc(F)c2c(=O)[nH]1
PDB

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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434462
PNG
(US10562891, Example 376 | US11008308, Example 376)
Show SMILES Brc1cc(OCC2CCOC2)cc2nc(CSC3CCOCC3)[nH]c(=O)c12
PDB

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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434468
PNG
(US10562891, Example 382 | US11008308, Example 382)
Show SMILES O[C@H]1C[C@@H](C1)SCc1nc2cc(OCC3CCOCC3)cc(F)c2c(=O)[nH]1
PDB

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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434469
PNG
(US10562891, Example 383 | US11008308, Example 383)
Show SMILES O=c1[nH]c(CSC2CCOCC2)nc2cc(OCC3CCOC3)cc(C#N)c12
PDB

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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434476
PNG
(US10562891, Example 390 | US11008308, Example 390)
Show SMILES Fc1cc(OCC2CCN(CC2)C(=O)C2CC2)cc2nc(CSC3CCOCC3)[nH]c(=O)c12
Show InChI InChI=1S/C24H30FN3O4S/c25-19-11-17(32-13-15-3-7-28(8-4-15)24(30)16-1-2-16)12-20-22(19)23(29)27-21(26-20)14-33-18-5-9-31-10-6-18/h11-12,15-16,18H,1-10,13-14H2,(H,26,27,29)
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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434478
PNG
(US10562891, Example 392 | US11008308, Example 392)
Show SMILES CC(=O)N[C@H]1CC[C@@H](CC1)SCc1nc2cc(NC3CCC3)c(F)c(F)c2c(=O)[nH]1
PDB

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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434480
PNG
(US10562891, Example 394 | US11008308, Example 394)
Show SMILES CC(Oc1cc(F)c2c(c1)nc(CSC1CCOCC1)[nH]c2=O)C1CCCC1
PDB

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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434510
PNG
(US10562891, Example 424 | US11008308, Example 424)
Show SMILES COCC(=O)N1CCC(COc2cc(F)c3c(c2)nc(CSC2CCOCC2)[nH]c3=O)CC1
Show InChI InChI=1S/C23H30FN3O5S/c1-30-13-21(28)27-6-2-15(3-7-27)12-32-16-10-18(24)22-19(11-16)25-20(26-23(22)29)14-33-17-4-8-31-9-5-17/h10-11,15,17H,2-9,12-14H2,1H3,(H,25,26,29)
PDB

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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434098
PNG
(US10562891, Example 20 | US11008308, Example 20)
Show SMILES Cc1cccc2c1nc(CSC1CCCNCC1)[nH]c2=O
PDB

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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434101
PNG
(US10562891, Example 23 | US11008308, Example 23)
Show SMILES Cc1cccc2c1nc(CS[C@H]1CC[C@H](O)CC1)[nH]c2=O
PDB

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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM497558
PNG
(US11008308, Example 60)
Show SMILES Cc1ccc(c2c1nc(CS[C@H]1CC[C@H](O)CC1)[nH]c2=O)C(F)(F)F
PDB

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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434157
PNG
(US10562891, Example 79 | US11008308, Example 79)
Show SMILES O=c1[nH]c(CSC2CCOCC2)nc2cc(Nc3ccccc3)ccc12
Show InChI InChI=1S/C20H21N3O2S/c24-20-17-7-6-15(21-14-4-2-1-3-5-14)12-18(17)22-19(23-20)13-26-16-8-10-25-11-9-16/h1-7,12,16,21H,8-11,13H2,(H,22,23,24)
PDB

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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434158
PNG
(US10562891, Example 80 | US11008308, Example 80)
Show SMILES O=c1[nH]c(CSC2CCOCC2)nc2cc(Nc3cccnc3)ccc12
Show InChI InChI=1S/C19H20N4O2S/c24-19-16-4-3-13(21-14-2-1-7-20-11-14)10-17(16)22-18(23-19)12-26-15-5-8-25-9-6-15/h1-4,7,10-11,15,21H,5-6,8-9,12H2,(H,22,23,24)
PDB

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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434176
PNG
(US10562891, Example 98 | US11008308, Example 98)
Show SMILES O[C@H]1CC[C@@H](CC1)SCc1nc2cc(Nc3ccccc3)ccc2c(=O)[nH]1
PDB

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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434178
PNG
(US10562891, Example 100 | US11008308, Example 100)
Show SMILES O[C@H]1CC[C@H](CC1)SCc1nc2cc(Nc3cccnc3)ccc2c(=O)[nH]1
PDB

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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434180
PNG
(US10562891, Example 102 | US11008308, Example 102)
Show SMILES O[C@H]1CC[C@@H](CC1)SCc1nc2cc(NC3CCCC3)ccc2c(=O)[nH]1
PDB

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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434185
PNG
(US10562891, Example 107 | US11008308, Example 107)
Show SMILES OC[C@H]1CC[C@@H](CC1)SCc1nc2cc(Nc3cccnc3)ccc2c(=O)[nH]1
PDB

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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434217
PNG
(US10562891, Example 139 | US11008308, Example 139)
Show SMILES CC(=O)Nc1ccc(CN2CCC(CC2)SCc2nc3c(C)cccc3c(=O)[nH]2)cc1
Show InChI InChI=1S/C24H28N4O2S/c1-16-4-3-5-21-23(16)26-22(27-24(21)30)15-31-20-10-12-28(13-11-20)14-18-6-8-19(9-7-18)25-17(2)29/h3-9,20H,10-15H2,1-2H3,(H,25,29)(H,26,27,30)
PDB

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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434240
PNG
(US10562891, Example 162 | US11008308, Example 162)
Show SMILES Cc1cccc2c1nc(CSC1CCN(CCO)CC1)[nH]c2=O
Show InChI InChI=1S/C17H23N3O2S/c1-12-3-2-4-14-16(12)18-15(19-17(14)22)11-23-13-5-7-20(8-6-13)9-10-21/h2-4,13,21H,5-11H2,1H3,(H,18,19,22)
PDB

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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434257
PNG
(US10562891, Example 179 | US11008308, Example 179)
Show SMILES O=c1[nH]c(CSC2CCNCC2)nc2cc(NC3CCCC3)ccc12
Show InChI InChI=1S/C19H26N4OS/c24-19-16-6-5-14(21-13-3-1-2-4-13)11-17(16)22-18(23-19)12-25-15-7-9-20-10-8-15/h5-6,11,13,15,20-21H,1-4,7-10,12H2,(H,22,23,24)
PDB

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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 14


(Homo sapiens (Human))
BDBM434271
PNG
(US10562891, Example 193 | US11008308, Example 193)
Show SMILES CS(=O)(=O)N1CCC[C@H](C1)Nc1ccc2c(c1)nc(CSC1CCOCC1)[nH]c2=O
PDB

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Ribon Therapeutics Inc.

US Patent


Assay Description
Enzymatic inhibition of PARP14 was measured using a dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA) monitoring the auto-modificati...


US Patent US11008308 (2021)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%