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Patent code US11008314

Compile Data Set for Download or QSAR

Found 623 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM498071
PNG
(US11008314, Compound 154)
Show SMILES COc1cc(C)c(Sc2cnc(Nc3ccccn3)s2)cc1C(=O)N(C)[C@@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H27N5O3S2/c1-5-22(31)30-11-9-17(15-30)29(3)24(32)18-13-20(16(2)12-19(18)33-4)34-23-14-27-25(35-23)28-21-8-6-7-10-26-21/h5-8,10,12-14,17H,1,9,11,15H2,2-4H3,(H,26,27,28)/t17-/m1/s1
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM498072
PNG
(US11008314, Compound 155)
Show SMILES COc1cc(C)c(Sc2cnc(NC(=O)c3ccsc3)s2)cc1C(=O)N1C[C@@H]2CC[C@H](C1)N2C(=O)C=C
Show InChI InChI=1S/C26H26N4O4S3/c1-4-22(31)30-17-5-6-18(30)13-29(12-17)25(33)19-10-21(15(2)9-20(19)34-3)36-23-11-27-26(37-23)28-24(32)16-7-8-35-14-16/h4,7-11,14,17-18H,1,5-6,12-13H2,2-3H3,(H,27,28,32)/t17-,18+
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM498072
PNG
(US11008314, Compound 155)
Show SMILES COc1cc(C)c(Sc2cnc(NC(=O)c3ccsc3)s2)cc1C(=O)N1C[C@@H]2CC[C@H](C1)N2C(=O)C=C
Show InChI InChI=1S/C26H26N4O4S3/c1-4-22(31)30-17-5-6-18(30)13-29(12-17)25(33)19-10-21(15(2)9-20(19)34-3)36-23-11-27-26(37-23)28-24(32)16-7-8-35-14-16/h4,7-11,14,17-18H,1,5-6,12-13H2,2-3H3,(H,27,28,32)/t17-,18+
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase TXK


(Homo sapiens (Human))
BDBM497910
PNG
(US11008314, Compound 5)
Show SMILES COc1cc(C)c(Sc2cnc(NC(C)=O)s2)cc1C(=O)N1CCN(CC1(C)C)C(=O)C=C
Show InChI InChI=1S/C23H28N4O4S2/c1-7-19(29)26-8-9-27(23(4,5)13-26)21(30)16-11-18(14(2)10-17(16)31-6)32-20-12-24-22(33-20)25-15(3)28/h7,10-12H,1,8-9,13H2,2-6H3,(H,24,25,28)
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM497918
PNG
(US11008314, Compound 11)
Show SMILES COc1cc(C)c(Sc2cnc(NC(C)=O)s2)cc1C(=O)N1CCN([C@H](C)C1)C(=O)C=C
Show InChI InChI=1S/C22H26N4O4S2/c1-6-19(28)26-8-7-25(12-14(26)3)21(29)16-10-18(13(2)9-17(16)30-5)31-20-11-23-22(32-20)24-15(4)27/h6,9-11,14H,1,7-8,12H2,2-5H3,(H,23,24,27)/t14-/m1/s1
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM497925
PNG
(US11008314, Compound 17)
Show SMILES COc1cc(C)c(Sc2cnc(NC(=O)C3CC3)s2)cc1C(=O)N1[C@H]2CC[C@@H]1CN(C2)C(=O)C=C
Show InChI InChI=1S/C25H28N4O4S2/c1-4-21(30)28-12-16-7-8-17(13-28)29(16)24(32)18-10-20(14(2)9-19(18)33-3)34-22-11-26-25(35-22)27-23(31)15-5-6-15/h4,9-11,15-17H,1,5-8,12-13H2,2-3H3,(H,26,27,31)/t16-,17+
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase TXK


(Homo sapiens (Human))
BDBM497926
PNG
(US11008314, Compound 18)
Show SMILES COc1cc(C)c(Sc2cnc(NC(=O)C3CC3)s2)cc1C(=O)N1C[C@@H]2CC[C@H](C1)N2C(=O)C=C
Show InChI InChI=1S/C25H28N4O4S2/c1-4-21(30)29-16-7-8-17(29)13-28(12-16)24(32)18-10-20(14(2)9-19(18)33-3)34-22-11-26-25(35-22)27-23(31)15-5-6-15/h4,9-11,15-17H,1,5-8,12-13H2,2-3H3,(H,26,27,31)/t16-,17+
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM497932
PNG
(US11008314, Compound 23)
Show SMILES COc1cc(C)c(Sc2cnc(NC(=O)C3CC3)s2)cc1C(=O)N1C[C@@H]2C[C@H]1CN2C(=O)C=C
Show InChI InChI=1S/C24H26N4O4S2/c1-4-20(29)27-11-16-8-15(27)12-28(16)23(31)17-9-19(13(2)7-18(17)32-3)33-21-10-25-24(34-21)26-22(30)14-5-6-14/h4,7,9-10,14-16H,1,5-6,8,11-12H2,2-3H3,(H,25,26,30)/t15-,16-/m0/s1
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM497950
PNG
(US11008314, Compound 40)
Show SMILES COc1cc(C)c(Sc2cnc(NC(=O)c3ccc(cc3)N3CCN(CC3)C(=O)OC(C)(C)C)s2)cc1C(=O)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C35H42N6O6S2/c1-7-29(42)39-14-16-40(17-15-39)32(44)26-21-28(23(2)20-27(26)46-6)48-30-22-36-33(49-30)37-31(43)24-8-10-25(11-9-24)38-12-18-41(19-13-38)34(45)47-35(3,4)5/h7-11,20-22H,1,12-19H2,2-6H3,(H,36,37,43)
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM497962
PNG
(US11008314, Compound 51)
Show SMILES CCC(=O)Nc1ncc(Sc2cc(C(=O)N3CCN(C[C@@H]3C)C(=O)C=C)c(OC)cc2C)s1
Show InChI InChI=1S/C23H28N4O4S2/c1-6-19(28)25-23-24-12-21(33-23)32-18-11-16(17(31-5)10-14(18)3)22(30)27-9-8-26(13-15(27)4)20(29)7-2/h7,10-12,15H,2,6,8-9,13H2,1,3-5H3,(H,24,25,28)/t15-/m0/s1
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM497963
PNG
(US11008314, Compound 52)
Show SMILES COc1cc(C)c(Sc2cnc(NC(=O)C3CC3)s2)cc1C(=O)N1C[C@@H]2CN([C@@H]2C1)C(=O)C=C
Show InChI InChI=1S/C24H26N4O4S2/c1-4-20(29)28-11-15-10-27(12-17(15)28)23(31)16-8-19(13(2)7-18(16)32-3)33-21-9-25-24(34-21)26-22(30)14-5-6-14/h4,7-9,14-15,17H,1,5-6,10-12H2,2-3H3,(H,25,26,30)/t15-,17-/m1/s1
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM497987
PNG
(US11008314, Compound 75)
Show SMILES C[C@@H]1CN(CCN1C(=O)C=C)C(=O)c1cc(Sc2cnc(NC(=O)C3CC3)s2)c(C)cc1C
Show InChI InChI=1S/C24H28N4O3S2/c1-5-20(29)28-9-8-27(13-16(28)4)23(31)18-11-19(15(3)10-14(18)2)32-21-12-25-24(33-21)26-22(30)17-6-7-17/h5,10-12,16-17H,1,6-9,13H2,2-4H3,(H,25,26,30)/t16-/m1/s1
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM497992
PNG
(US11008314, Compound 80)
Show SMILES Cc1cc(Cl)c(Sc2cnc(NC(=O)C3CC3)s2)cc1C(=O)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C22H23ClN4O3S2/c1-3-18(28)26-6-8-27(9-7-26)21(30)15-11-17(16(23)10-13(15)2)31-19-12-24-22(32-19)25-20(29)14-4-5-14/h3,10-12,14H,1,4-9H2,2H3,(H,24,25,29)
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase TXK


(Homo sapiens (Human))
BDBM498002
PNG
(US11008314, Compound 90)
Show SMILES COc1cc(C)c(Sc2cnc(NC(=O)c3ccsc3)s2)cc1C(=O)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C24H24N4O4S3/c1-4-20(29)27-6-8-28(9-7-27)23(31)17-12-19(15(2)11-18(17)32-3)34-21-13-25-24(35-21)26-22(30)16-5-10-33-14-16/h4-5,10-14H,1,6-9H2,2-3H3,(H,25,26,30)
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase TXK


(Homo sapiens (Human))
BDBM498010
PNG
(US11008314, Compound 135 | US11008314, Compound 98)
Show SMILES COc1cc(C)c(Sc2cnc(Nc3ccccn3)s2)cc1C(=O)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C24H25N5O3S2/c1-4-21(30)28-9-11-29(12-10-28)23(31)17-14-19(16(2)13-18(17)32-3)33-22-15-26-24(34-22)27-20-7-5-6-8-25-20/h4-8,13-15H,1,9-12H2,2-3H3,(H,25,26,27)
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM498039
PNG
(US11008314, Compound 123)
Show SMILES CC[C@@H]1CN(CCCN1C(=O)C=C)C(=O)c1cc(Sc2cnc(NC(=O)c3cnsc3)s2)c(C)cc1C
Show InChI InChI=1S/C26H29N5O3S3/c1-5-19-14-30(8-7-9-31(19)22(32)6-2)25(34)20-11-21(17(4)10-16(20)3)36-23-13-27-26(37-23)29-24(33)18-12-28-35-15-18/h6,10-13,15,19H,2,5,7-9,14H2,1,3-4H3,(H,27,29,33)/t19-/m1/s1
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM498059
PNG
(US11008314, Compound 142)
Show SMILES COc1cc(C)c(Sc2cnc(NC(=O)c3ccsc3)s2)cc1C(=O)N1CCN(CC1(C)C)C(=O)C=C
Show InChI InChI=1S/C26H28N4O4S3/c1-6-21(31)29-8-9-30(26(3,4)15-29)24(33)18-12-20(16(2)11-19(18)34-5)36-22-13-27-25(37-22)28-23(32)17-7-10-35-14-17/h6-7,10-14H,1,8-9,15H2,2-5H3,(H,27,28,32)
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM498060
PNG
(US11008314, Compound 143)
Show SMILES COc1cc(C)c(Sc2cnc(NC(=O)c3ccsc3)s2)cc1C(=O)N1[C@H]2CC[C@@H]1CN(C2)C(=O)C=C
Show InChI InChI=1S/C26H26N4O4S3/c1-4-22(31)29-12-17-5-6-18(13-29)30(17)25(33)19-10-21(15(2)9-20(19)34-3)36-23-11-27-26(37-23)28-24(32)16-7-8-35-14-16/h4,7-11,14,17-18H,1,5-6,12-13H2,2-3H3,(H,27,28,32)/t17-,18+
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM498065
PNG
(US11008314, Compound 148)
Show SMILES COc1cc(C)c(Sc2cnc(NC(=O)C3CC3)s2)cc1C(=O)N1CCCN([C@@H](C1)C(C)C)C(=O)C=C
Show InChI InChI=1S/C27H34N4O4S2/c1-6-23(32)31-11-7-10-30(15-20(31)16(2)3)26(34)19-13-22(17(4)12-21(19)35-5)36-24-14-28-27(37-24)29-25(33)18-8-9-18/h6,12-14,16,18,20H,1,7-11,15H2,2-5H3,(H,28,29,33)/t20-/m0/s1
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM498066
PNG
(US11008314, Compound 149)
Show SMILES COc1cc(C)c(Sc2cnc(NC(=O)c3ccsc3)s2)cc1C(=O)N1CCCN([C@@H](C1)C(C)C)C(=O)C=C
Show InChI InChI=1S/C28H32N4O4S3/c1-6-24(33)32-10-7-9-31(15-21(32)17(2)3)27(35)20-13-23(18(4)12-22(20)36-5)38-25-14-29-28(39-25)30-26(34)19-8-11-37-16-19/h6,8,11-14,16-17,21H,1,7,9-10,15H2,2-5H3,(H,29,30,34)/t21-/m0/s1
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase TXK


(Homo sapiens (Human))
BDBM498067
PNG
(US11008314, Compound 150)
Show SMILES COc1cc(C)c(Sc2cnc(Nc3ccccn3)s2)cc1C(=O)N1C[C@@H]2CC[C@H](C1)N2C(=O)C=C
Show InChI InChI=1S/C26H27N5O3S2/c1-4-23(32)31-17-8-9-18(31)15-30(14-17)25(33)19-12-21(16(2)11-20(19)34-3)35-24-13-28-26(36-24)29-22-7-5-6-10-27-22/h4-7,10-13,17-18H,1,8-9,14-15H2,2-3H3,(H,27,28,29)/t17-,18+
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM498068
PNG
(US11008314, Compound 151)
Show SMILES COc1cc(C)c(Sc2cnc(Nc3ccccn3)s2)cc1C(=O)N1CCN(C[C@@H]1C)C(=O)C=C
Show InChI InChI=1S/C25H27N5O3S2/c1-5-22(31)29-10-11-30(17(3)15-29)24(32)18-13-20(16(2)12-19(18)33-4)34-23-14-27-25(35-23)28-21-8-6-7-9-26-21/h5-9,12-14,17H,1,10-11,15H2,2-4H3,(H,26,27,28)/t17-/m0/s1
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase TXK


(Homo sapiens (Human))
BDBM498068
PNG
(US11008314, Compound 151)
Show SMILES COc1cc(C)c(Sc2cnc(Nc3ccccn3)s2)cc1C(=O)N1CCN(C[C@@H]1C)C(=O)C=C
Show InChI InChI=1S/C25H27N5O3S2/c1-5-22(31)29-10-11-30(17(3)15-29)24(32)18-13-20(16(2)12-19(18)33-4)34-23-14-27-25(35-23)28-21-8-6-7-9-26-21/h5-9,12-14,17H,1,10-11,15H2,2-4H3,(H,26,27,28)/t17-/m0/s1
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM498070
PNG
(US11008314, Compound 153)
Show SMILES COc1cc(C)c(Sc2cnc(Nc3ccccn3)s2)cc1C(=O)N1CCN([C@@H](C1)C#N)C(=O)C=C
Show InChI InChI=1S/C25H24N6O3S2/c1-4-22(32)31-10-9-30(15-17(31)13-26)24(33)18-12-20(16(2)11-19(18)34-3)35-23-14-28-25(36-23)29-21-7-5-6-8-27-21/h4-8,11-12,14,17H,1,9-10,15H2,2-3H3,(H,27,28,29)/t17-/m1/s1
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM497912
PNG
(US11008314, Compound 7)
Show SMILES COc1cc(C)c(Sc2cnc(NC(C)=O)s2)cc1C(=O)N1[C@H]2CC[C@@H]1CN(C2)C(=O)C=C
Show InChI InChI=1S/C23H26N4O4S2/c1-5-20(29)26-11-15-6-7-16(12-26)27(15)22(30)17-9-19(13(2)8-18(17)31-4)32-21-10-24-23(33-21)25-14(3)28/h5,8-10,15-16H,1,6-7,11-12H2,2-4H3,(H,24,25,28)/t15-,16+
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM497916
PNG
(US11008314, Compound 9)
Show SMILES COc1cc(C)c(Sc2cnc(NC(C)=O)s2)cc1C(=O)N1CCN(C[C@@H]1C)C(=O)C=C
Show InChI InChI=1S/C22H26N4O4S2/c1-6-19(28)25-7-8-26(14(3)12-25)21(29)16-10-18(13(2)9-17(16)30-5)31-20-11-23-22(32-20)24-15(4)27/h6,9-11,14H,1,7-8,12H2,2-5H3,(H,23,24,27)/t14-/m0/s1
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase TXK


(Homo sapiens (Human))
BDBM497925
PNG
(US11008314, Compound 17)
Show SMILES COc1cc(C)c(Sc2cnc(NC(=O)C3CC3)s2)cc1C(=O)N1[C@H]2CC[C@@H]1CN(C2)C(=O)C=C
Show InChI InChI=1S/C25H28N4O4S2/c1-4-21(30)28-12-16-7-8-17(13-28)29(16)24(32)18-10-20(14(2)9-19(18)33-3)34-22-11-26-25(35-22)27-23(31)15-5-6-15/h4,9-11,15-17H,1,5-8,12-13H2,2-3H3,(H,26,27,31)/t16-,17+
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM497925
PNG
(US11008314, Compound 17)
Show SMILES COc1cc(C)c(Sc2cnc(NC(=O)C3CC3)s2)cc1C(=O)N1[C@H]2CC[C@@H]1CN(C2)C(=O)C=C
Show InChI InChI=1S/C25H28N4O4S2/c1-4-21(30)28-12-16-7-8-17(13-28)29(16)24(32)18-10-20(14(2)9-19(18)33-3)34-22-11-26-25(35-22)27-23(31)15-5-6-15/h4,9-11,15-17H,1,5-8,12-13H2,2-3H3,(H,26,27,31)/t16-,17+
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM497952
PNG
(US11008314, Compound 42)
Show SMILES CC[C@@H]1CN(CCN1C(=O)C=C)C(=O)c1cc(Sc2cnc(NC(=O)C3CC3)s2)c(C)cc1OC
Show InChI InChI=1S/C25H30N4O4S2/c1-5-17-14-28(9-10-29(17)21(30)6-2)24(32)18-12-20(15(3)11-19(18)33-4)34-22-13-26-25(35-22)27-23(31)16-7-8-16/h6,11-13,16-17H,2,5,7-10,14H2,1,3-4H3,(H,26,27,31)/t17-/m1/s1
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase TXK


(Homo sapiens (Human))
BDBM497956
PNG
(US11008314, Compound 45)
Show SMILES COc1cc(C)c(Sc2cnc(NC(=O)C3CC3)s2)cc1C(=O)N1CCC2(CN(C2)C(=O)C=C)C1
Show InChI InChI=1S/C25H28N4O4S2/c1-4-20(30)29-13-25(14-29)7-8-28(12-25)23(32)17-10-19(15(2)9-18(17)33-3)34-21-11-26-24(35-21)27-22(31)16-5-6-16/h4,9-11,16H,1,5-8,12-14H2,2-3H3,(H,26,27,31)
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM497985
PNG
(US11008314, Compound 73)
Show SMILES Cc1cc(C)c(cc1Sc1cnc(NC(=O)C2CC2)s1)C(=O)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C23H26N4O3S2/c1-4-19(28)26-7-9-27(10-8-26)22(30)17-12-18(15(3)11-14(17)2)31-20-13-24-23(32-20)25-21(29)16-5-6-16/h4,11-13,16H,1,5-10H2,2-3H3,(H,24,25,29)
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM497986
PNG
(US11008314, Compound 74)
Show SMILES Cc1cc(C)c(cc1Sc1cnc(NC(=O)C2CC2)s1)C(=O)N1CCCN(CC1)C(=O)C=C
Show InChI InChI=1S/C24H28N4O3S2/c1-4-20(29)27-8-5-9-28(11-10-27)23(31)18-13-19(16(3)12-15(18)2)32-21-14-25-24(33-21)26-22(30)17-6-7-17/h4,12-14,17H,1,5-11H2,2-3H3,(H,25,26,30)
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM498023
PNG
(US11008314, Compound 108)
Show SMILES Cc1cc(C)c(cc1Sc1cnc(NC(=O)c2cnn(C)c2)s1)C(=O)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C24H26N6O3S2/c1-5-20(31)29-6-8-30(9-7-29)23(33)18-11-19(16(3)10-15(18)2)34-21-13-25-24(35-21)27-22(32)17-12-26-28(4)14-17/h5,10-14H,1,6-9H2,2-4H3,(H,25,27,32)
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM498035
PNG
(US11008314, Compound 119)
Show SMILES CC(=O)Nc1ncc(Sc2cc(C(=O)N3CCN([C@@H](C3)C#N)C(=O)C=C)c(C)cc2C)s1
Show InChI InChI=1S/C22H23N5O3S2/c1-5-19(29)27-7-6-26(12-16(27)10-23)21(30)17-9-18(14(3)8-13(17)2)31-20-11-24-22(32-20)25-15(4)28/h5,8-9,11,16H,1,6-7,12H2,2-4H3,(H,24,25,28)/t16-/m1/s1
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM498035
PNG
(US11008314, Compound 119)
Show SMILES CC(=O)Nc1ncc(Sc2cc(C(=O)N3CCN([C@@H](C3)C#N)C(=O)C=C)c(C)cc2C)s1
Show InChI InChI=1S/C22H23N5O3S2/c1-5-19(29)27-7-6-26(12-16(27)10-23)21(30)17-9-18(14(3)8-13(17)2)31-20-11-24-22(32-20)25-15(4)28/h5,8-9,11,16H,1,6-7,12H2,2-4H3,(H,24,25,28)/t16-/m1/s1
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM498037
PNG
(US11008314, Compound 121)
Show SMILES CC[C@@H]1CN(CCCN1C(=O)C=C)C(=O)c1cc(Sc2cnc(NC(=O)c3cnsc3)s2)c(C)cc1OC
Show InChI InChI=1S/C26H29N5O4S3/c1-5-18-14-30(8-7-9-31(18)22(32)6-2)25(34)19-11-21(16(3)10-20(19)35-4)37-23-13-27-26(38-23)29-24(33)17-12-28-36-15-17/h6,10-13,15,18H,2,5,7-9,14H2,1,3-4H3,(H,27,29,33)/t18-/m1/s1
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM498040
PNG
(US11008314, Compound 124)
Show SMILES COc1cc(C)c(Sc2cnc(NC(=O)c3cccc(CN(C)C)c3)s2)cc1C(=O)N1CCN([C@@H](C1)C#N)C(=O)C=C
Show InChI InChI=1S/C30H32N6O4S2/c1-6-26(37)36-11-10-35(18-22(36)15-31)29(39)23-14-25(19(2)12-24(23)40-5)41-27-16-32-30(42-27)33-28(38)21-9-7-8-20(13-21)17-34(3)4/h6-9,12-14,16,22H,1,10-11,17-18H2,2-5H3,(H,32,33,38)/t22-/m1/s1
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM498046
PNG
(US11008314, Compound 130)
Show SMILES CC[C@@H]1CN(CCN1C(=O)C=C)C(=O)c1cc(Sc2cnc(NC(=O)c3ccsc3)s2)c(C)cc1C
Show InChI InChI=1S/C26H28N4O3S3/c1-5-19-14-29(8-9-30(19)22(31)6-2)25(33)20-12-21(17(4)11-16(20)3)35-23-13-27-26(36-23)28-24(32)18-7-10-34-15-18/h6-7,10-13,15,19H,2,5,8-9,14H2,1,3-4H3,(H,27,28,32)/t19-/m1/s1
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase TXK


(Homo sapiens (Human))
BDBM498050
PNG
(US11008314, Compound 133)
Show SMILES Cc1cc(C)c(cc1Sc1cnc(Nc2ccccn2)s1)C(=O)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C24H25N5O2S2/c1-4-21(30)28-9-11-29(12-10-28)23(31)18-14-19(17(3)13-16(18)2)32-22-15-26-24(33-22)27-20-7-5-6-8-25-20/h4-8,13-15H,1,9-12H2,2-3H3,(H,25,26,27)
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase TXK


(Homo sapiens (Human))
BDBM498069
PNG
(US11008314, Compound 152)
Show SMILES COc1cc(C)c(Sc2cnc(Nc3ccccn3)s2)cc1C(=O)N1CC2(C1)CCN(C2)C(=O)C=C
Show InChI InChI=1S/C26H27N5O3S2/c1-4-22(32)30-10-8-26(14-30)15-31(16-26)24(33)18-12-20(17(2)11-19(18)34-3)35-23-13-28-25(36-23)29-21-7-5-6-9-27-21/h4-7,9,11-13H,1,8,10,14-16H2,2-3H3,(H,27,28,29)
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM498071
PNG
(US11008314, Compound 154)
Show SMILES COc1cc(C)c(Sc2cnc(Nc3ccccn3)s2)cc1C(=O)N(C)[C@@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H27N5O3S2/c1-5-22(31)30-11-9-17(15-30)29(3)24(32)18-13-20(16(2)12-19(18)33-4)34-23-14-27-25(35-23)28-21-8-6-7-10-26-21/h5-8,10,12-14,17H,1,9,11,15H2,2-4H3,(H,26,27,28)/t17-/m1/s1
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase TXK


(Homo sapiens (Human))
BDBM498071
PNG
(US11008314, Compound 154)
Show SMILES COc1cc(C)c(Sc2cnc(Nc3ccccn3)s2)cc1C(=O)N(C)[C@@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H27N5O3S2/c1-5-22(31)30-11-9-17(15-30)29(3)24(32)18-13-20(16(2)12-19(18)33-4)34-23-14-27-25(35-23)28-21-8-6-7-10-26-21/h5-8,10,12-14,17H,1,9,11,15H2,2-4H3,(H,26,27,28)/t17-/m1/s1
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n/an/a<1n/an/an/an/an/an/a



Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM498073
PNG
(US11008314, Compound 156)
Show SMILES COc1cc(C)c(Sc2cnc(NC(=O)c3ccsc3)s2)cc1C(=O)N1CCN([C@@H](C1)C#N)C(=O)C=C
Show InChI InChI=1S/C25H23N5O4S3/c1-4-21(31)30-7-6-29(13-17(30)11-26)24(33)18-10-20(15(2)9-19(18)34-3)36-22-12-27-25(37-22)28-23(32)16-5-8-35-14-16/h4-5,8-10,12,14,17H,1,6-7,13H2,2-3H3,(H,27,28,32)/t17-/m1/s1
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM497907
PNG
(US11008314, Compound 1)
Show SMILES COc1cc(C)c(Sc2cnc(NC(=O)C3CC3)s2)cc1C(=O)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C23H26N4O4S2/c1-4-19(28)26-7-9-27(10-8-26)22(30)16-12-18(14(2)11-17(16)31-3)32-20-13-24-23(33-20)25-21(29)15-5-6-15/h4,11-13,15H,1,5-10H2,2-3H3,(H,24,25,29)
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase TXK


(Homo sapiens (Human))
BDBM497907
PNG
(US11008314, Compound 1)
Show SMILES COc1cc(C)c(Sc2cnc(NC(=O)C3CC3)s2)cc1C(=O)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C23H26N4O4S2/c1-4-19(28)26-7-9-27(10-8-26)22(30)16-12-18(14(2)11-17(16)31-3)32-20-13-24-23(33-20)25-21(29)15-5-6-15/h4,11-13,15H,1,5-10H2,2-3H3,(H,24,25,29)
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n/an/a<1n/an/an/an/an/an/a



Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM497961
PNG
(US11008314, Compound 50)
Show SMILES COc1cc(C)c(Sc2cnc(NC(=O)c3ccc(F)c(CN(C)C)c3)s2)cc1C(=O)N1CCCN(CC1)C(=O)C=C
Show InChI InChI=1S/C30H34FN5O4S2/c1-6-26(37)35-10-7-11-36(13-12-35)29(39)22-16-25(19(2)14-24(22)40-5)41-27-17-32-30(42-27)33-28(38)20-8-9-23(31)21(15-20)18-34(3)4/h6,8-9,14-17H,1,7,10-13,18H2,2-5H3,(H,32,33,38)
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM497996
PNG
(US11008314, Compound 84)
Show SMILES COc1cc(C)c(Sc2cnc(NC(=O)C3CCC3)s2)cc1C(=O)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C24H28N4O4S2/c1-4-20(29)27-8-10-28(11-9-27)23(31)17-13-19(15(2)12-18(17)32-3)33-21-14-25-24(34-21)26-22(30)16-6-5-7-16/h4,12-14,16H,1,5-11H2,2-3H3,(H,25,26,30)
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM498002
PNG
(US11008314, Compound 90)
Show SMILES COc1cc(C)c(Sc2cnc(NC(=O)c3ccsc3)s2)cc1C(=O)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C24H24N4O4S3/c1-4-20(29)27-6-8-28(9-7-27)23(31)17-12-19(15(2)11-18(17)32-3)34-21-13-25-24(35-21)26-22(30)16-5-10-33-14-16/h4-5,10-14H,1,6-9H2,2-3H3,(H,25,26,30)
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM498015
PNG
(US11008314, Compound 103)
Show SMILES COc1cc(C)c(Sc2cnc(Nc3ccccn3)s2)cc1C(=O)N1CCCN([C@H](C)C1)C(=O)C=C
Show InChI InChI=1S/C26H29N5O3S2/c1-5-23(32)31-12-8-11-30(16-18(31)3)25(33)19-14-21(17(2)13-20(19)34-4)35-24-15-28-26(36-24)29-22-9-6-7-10-27-22/h5-7,9-10,13-15,18H,1,8,11-12,16H2,2-4H3,(H,27,28,29)/t18-/m1/s1
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens (Human))
BDBM498027
PNG
(US11008314, Compound 112)
Show SMILES CC[C@@H]1CN(CCCN1C(=O)C=C)C(=O)c1cc(Sc2cnc(NC(=O)C3CC3)s2)c(C)cc1C
Show InChI InChI=1S/C26H32N4O3S2/c1-5-19-15-29(10-7-11-30(19)22(31)6-2)25(33)20-13-21(17(4)12-16(20)3)34-23-14-27-26(35-23)28-24(32)18-8-9-18/h6,12-14,18-19H,2,5,7-11,15H2,1,3-4H3,(H,27,28,32)/t19-/m1/s1
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Corvus Pharmaceuticals, Inc.

US Patent


Assay Description
The potency of inhibition is measured by binding affinity.


US Patent US11008314 (2021)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 623 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%