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Patent code US11013745

Compile Data Set for Download or QSAR
Found 80 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498166
PNG
(US11013745, Compound SL-E14)
Show SMILES CS(=O)(=O)N1CCC=C(CC1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C21H23FN6O3S/c1-32(29,30)27-8-2-3-14(6-9-27)16-11-23-21(28-13-25-26-20(16)28)24-12-17-15-7-10-31-19(15)5-4-18(17)22/h3-5,11,13H,2,6-10,12H2,1H3,(H,23,24)
PDB

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US Patent
n/an/a 1.70n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498165
PNG
(US11013745, Compound SL-ZYE-183)
Show SMILES COC(=O)N1CCC=C(CC1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C22H23FN6O3/c1-31-22(30)28-8-2-3-14(6-9-28)16-11-24-21(29-13-26-27-20(16)29)25-12-17-15-7-10-32-19(15)5-4-18(17)23/h3-5,11,13H,2,6-10,12H2,1H3,(H,24,25)
PDB

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US Patent
n/an/a 2.20n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498157
PNG
(US11013745, Compound SL-ZYE-147)
Show SMILES COC(=O)N1CCC(=CC1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C21H21FN6O3/c1-30-21(29)27-7-4-13(5-8-27)15-10-23-20(28-12-25-26-19(15)28)24-11-16-14-6-9-31-18(14)3-2-17(16)22/h2-4,10,12H,5-9,11H2,1H3,(H,23,24)
PDB

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US Patent
n/an/a 2.5n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498156
PNG
(US11013745, Compound SL-ZYE-146)
Show SMILES Fc1ccc2OCCc2c1CNc1ncc(C2=CCN(CC2)S(=O)(=O)C2CC2)c2nncn12
Show InChI InChI=1S/C22H23FN6O3S/c23-19-3-4-20-16(7-10-32-20)18(19)12-25-22-24-11-17(21-27-26-13-29(21)22)14-5-8-28(9-6-14)33(30,31)15-1-2-15/h3-5,11,13,15H,1-2,6-10,12H2,(H,24,25)
PDB

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US Patent
n/an/a 2.90n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498150
PNG
(US11013745, Compound SL-ZYE-34)
Show SMILES Fc1ccc2OCCc2c1CNc1ncc(C2CCS(=O)(=O)CC2)c2nncn12
Show InChI InChI=1S/C19H20FN5O3S/c20-16-1-2-17-13(3-6-28-17)15(16)10-22-19-21-9-14(18-24-23-11-25(18)19)12-4-7-29(26,27)8-5-12/h1-2,9,11-12H,3-8,10H2,(H,21,22)
PDB

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US Patent
n/an/a 3.20n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498164
PNG
(US11013745, Compound SL-E13)
Show SMILES CC(=O)N1CCC=C(CC1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C22H23FN6O2/c1-14(30)28-8-2-3-15(6-9-28)17-11-24-22(29-13-26-27-21(17)29)25-12-18-16-7-10-31-20(16)5-4-19(18)23/h3-5,11,13H,2,6-10,12H2,1H3,(H,24,25)
PDB

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US Patent
n/an/a 3.30n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498129
PNG
(US11013745, Compound E-Y45)
Show SMILES Fc1ccc2OCCc2c1CNc1ncc(C2=CCN(CC2)C(=O)C=C)c2nncn12
Show InChI InChI=1S/C22H21FN6O2/c1-2-20(30)28-8-5-14(6-9-28)16-11-24-22(29-13-26-27-21(16)29)25-12-17-15-7-10-31-19(15)4-3-18(17)23/h2-5,11,13H,1,6-10,12H2,(H,24,25)
PDB

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US Patent
n/an/a 3.40n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498155
PNG
(US11013745, Compound SL-ZYE-144)
Show SMILES CCS(=O)(=O)N1CCC(=CC1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C21H23FN6O3S/c1-2-32(29,30)27-8-5-14(6-9-27)16-11-23-21(28-13-25-26-20(16)28)24-12-17-15-7-10-31-19(15)4-3-18(17)22/h3-5,11,13H,2,6-10,12H2,1H3,(H,23,24)
PDB

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n/an/a 3.5n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498170
PNG
(US11013745, Compound SL-ZYE-120)
Show SMILES CC1(C)OCCC(=C1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C21H22FN5O2/c1-21(2)9-13(5-8-29-21)15-10-23-20(27-12-25-26-19(15)27)24-11-16-14-6-7-28-18(14)4-3-17(16)22/h3-4,9-10,12H,5-8,11H2,1-2H3,(H,23,24)
PDB

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US Patent
n/an/a 3.60n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498162
PNG
(US11013745, Compound SL-E24)
Show SMILES CN1CCC(=CC1=O)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C20H19FN6O2/c1-26-6-4-12(8-18(26)28)14-9-22-20(27-11-24-25-19(14)27)23-10-15-13-5-7-29-17(13)3-2-16(15)21/h2-3,8-9,11H,4-7,10H2,1H3,(H,22,23)
PDB

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US Patent
n/an/a 3.90n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498136
PNG
(US11013745, Compound E-Y54 | US11013745, Compound ...)
Show SMILES CN(C)CC(=O)N1CCC(=CC1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C23H26FN7O2/c1-29(2)13-21(32)30-8-5-15(6-9-30)17-11-25-23(31-14-27-28-22(17)31)26-12-18-16-7-10-33-20(16)4-3-19(18)24/h3-5,11,14H,6-10,12-13H2,1-2H3,(H,25,26)
PDB

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US Patent
n/an/a 4.10n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498171
PNG
(US11013745, Compound SL-ZYE-121)
Show SMILES CC1(C)CC(CCO1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C21H24FN5O2/c1-21(2)9-13(5-8-29-21)15-10-23-20(27-12-25-26-19(15)27)24-11-16-14-6-7-28-18(14)4-3-17(16)22/h3-4,10,12-13H,5-9,11H2,1-2H3,(H,23,24)
PDB

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n/an/a 4.20n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498140
PNG
(US11013745, Compound SL-ZYE-09)
Show SMILES Fc1ccc2OCCc2c1CNc1ncc(C2=CCS(=O)(=O)CC2)c2nncn12
Show InChI InChI=1S/C19H18FN5O3S/c20-16-1-2-17-13(3-6-28-17)15(16)10-22-19-21-9-14(18-24-23-11-25(18)19)12-4-7-29(26,27)8-5-12/h1-2,4,9,11H,3,5-8,10H2,(H,21,22)
PDB

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US Patent
n/an/a 4.5n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498158
PNG
(US11013745, Compound SL-ZYE-148)
Show SMILES CCOC(=O)N1CCC(=CC1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C22H23FN6O3/c1-2-31-22(30)28-8-5-14(6-9-28)16-11-24-21(29-13-26-27-20(16)29)25-12-17-15-7-10-32-19(15)4-3-18(17)23/h3-5,11,13H,2,6-10,12H2,1H3,(H,24,25)
PDB

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US Patent
n/an/a 4.70n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498152
PNG
(US11013745, Compound SL-E23)
Show SMILES CN1CCC(=CC1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C20H21FN6O/c1-26-7-4-13(5-8-26)15-10-22-20(27-12-24-25-19(15)27)23-11-16-14-6-9-28-18(14)3-2-17(16)21/h2-4,10,12H,5-9,11H2,1H3,(H,22,23)
PDB

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UniChem
US Patent
n/an/a 4.70n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498126
PNG
(US11013745, Compound E-Y42)
Show SMILES Cc1cc(C(=O)N2CCC(=CC2)c2cnc(NCc3c4CCOc4ccc3F)n3cnnc23)n(C)n1
Show InChI InChI=1S/C25H25FN8O2/c1-15-11-21(32(2)31-15)24(35)33-8-5-16(6-9-33)18-12-27-25(34-14-29-30-23(18)34)28-13-19-17-7-10-36-22(17)4-3-20(19)26/h3-5,11-12,14H,6-10,13H2,1-2H3,(H,27,28)
PDB

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US Patent
n/an/a 4.80n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498136
PNG
(US11013745, Compound E-Y54 | US11013745, Compound ...)
Show SMILES CN(C)CC(=O)N1CCC(=CC1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C23H26FN7O2/c1-29(2)13-21(32)30-8-5-15(6-9-30)17-11-25-23(31-14-27-28-22(17)31)26-12-18-16-7-10-33-20(16)4-3-19(18)24/h3-5,11,14H,6-10,12-13H2,1-2H3,(H,25,26)
PDB

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n/an/a 5n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498160
PNG
(US11013745, Compound SL-ZYE-162)
Show SMILES Fc1ccc2OCCc2c1CNc1ncc(C2=CCN(CC2)C(=O)C2CC2)c2nncn12
Show InChI InChI=1S/C23H23FN6O2/c24-19-3-4-20-16(7-10-32-20)18(19)12-26-23-25-11-17(21-28-27-13-30(21)23)14-5-8-29(9-6-14)22(31)15-1-2-15/h3-5,11,13,15H,1-2,6-10,12H2,(H,25,26)
PDB

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US Patent
n/an/a 5.20n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498134
PNG
(US11013745, Compound E-Y50)
Show SMILES CC(=O)N1CCC(CC1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C21H23FN6O2/c1-13(29)27-7-4-14(5-8-27)16-10-23-21(28-12-25-26-20(16)28)24-11-17-15-6-9-30-19(15)3-2-18(17)22/h2-3,10,12,14H,4-9,11H2,1H3,(H,23,24)
PDB

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US Patent
n/an/a 5.30n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498132
PNG
(US11013745, Compound E-Y48)
Show SMILES CCNC(=O)N1CCC(CC1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C22H26FN7O2/c1-2-24-22(31)29-8-5-14(6-9-29)16-11-25-21(30-13-27-28-20(16)30)26-12-17-15-7-10-32-19(15)4-3-18(17)23/h3-4,11,13-14H,2,5-10,12H2,1H3,(H,24,31)(H,25,26)
PDB

UniProtKB/SwissProt

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US Patent
n/an/a 5.40n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498096
PNG
(US11013745, Compound E-Y15)
Show SMILES CC(=O)N1CCC(=CC1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C21H21FN6O2/c1-13(29)27-7-4-14(5-8-27)16-10-23-21(28-12-25-26-20(16)28)24-11-17-15-6-9-30-19(15)3-2-18(17)22/h2-4,10,12H,5-9,11H2,1H3,(H,23,24)
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n/an/a 5.60n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498098
PNG
(US11013745, Compound E-Y17)
Show SMILES CCNC(=O)N1CCC(=CC1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C22H24FN7O2/c1-2-24-22(31)29-8-5-14(6-9-29)16-11-25-21(30-13-27-28-20(16)30)26-12-17-15-7-10-32-19(15)4-3-18(17)23/h3-5,11,13H,2,6-10,12H2,1H3,(H,24,31)(H,25,26)
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n/an/a 6.10n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498133
PNG
(US11013745, Compound E-Y49)
Show SMILES CC(C)(C)NC(=O)N1CCC(CC1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C24H30FN7O2/c1-24(2,3)29-23(33)31-9-6-15(7-10-31)17-12-26-22(32-14-28-30-21(17)32)27-13-18-16-8-11-34-20(16)5-4-19(18)25/h4-5,12,14-15H,6-11,13H2,1-3H3,(H,26,27)(H,29,33)
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n/an/a 6.60n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498137
PNG
(US11013745, Compound SL-ZYE-07)
Show SMILES Fc1ccc2OCCc2c1CNc1ncc(C2=CCCOCC2)c2nncn12
Show InChI InChI=1S/C20H20FN5O2/c21-17-3-4-18-14(6-9-28-18)16(17)11-23-20-22-10-15(19-25-24-12-26(19)20)13-2-1-7-27-8-5-13/h2-4,10,12H,1,5-9,11H2,(H,22,23)
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n/an/a 7.30n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498169
PNG
(US11013745, Compound SL-ZYE-197)
Show SMILES CC1OCCC(=C1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C20H20FN5O2/c1-12-8-13(4-6-27-12)15-9-22-20(26-11-24-25-19(15)26)23-10-16-14-5-7-28-18(14)3-2-17(16)21/h2-3,8-9,11-12H,4-7,10H2,1H3,(H,22,23)
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n/an/a 7.80n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498084
PNG
(US11013745, Compound E-Y2)
Show SMILES Fc1ccc2OCCc2c1CNc1ncc(C2=CCSCC2)c2nncn12
Show InChI InChI=1S/C19H18FN5OS/c20-16-1-2-17-13(3-6-26-17)15(16)10-22-19-21-9-14(12-4-7-27-8-5-12)18-24-23-11-25(18)19/h1-2,4,9,11H,3,5-8,10H2,(H,21,22)
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n/an/a 8n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498148
PNG
(US11013745, Compound SL-ZYE-24)
Show SMILES CC1CC(=CC(C)O1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C21H22FN5O2/c1-12-7-14(8-13(2)29-12)16-9-23-21(27-11-25-26-20(16)27)24-10-17-15-5-6-28-19(15)4-3-18(17)22/h3-4,7,9,11-13H,5-6,8,10H2,1-2H3,(H,23,24)
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n/an/a 8.30n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498163
PNG
(US11013745, Compound SL-E26)
Show SMILES CN1CCC(CC1=O)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C20H21FN6O2/c1-26-6-4-12(8-18(26)28)14-9-22-20(27-11-24-25-19(14)27)23-10-15-13-5-7-29-17(13)3-2-16(15)21/h2-3,9,11-12H,4-8,10H2,1H3,(H,22,23)
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n/an/a 8.40n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498127
PNG
(US11013745, Compound E-Y43)
Show SMILES Fc1ccc2OCCc2c1CNc1ncc(C2=CCN(CC2)C(=O)C2CCOCC2)c2nncn12
Show InChI InChI=1S/C25H27FN6O3/c26-21-1-2-22-18(7-12-35-22)20(21)14-28-25-27-13-19(23-30-29-15-32(23)25)16-3-8-31(9-4-16)24(33)17-5-10-34-11-6-17/h1-3,13,15,17H,4-12,14H2,(H,27,28)
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n/an/a 8.5n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498161
PNG
(US11013745, Compound SL-ZYE-145)
Show SMILES CC(C)S(=O)(=O)N1CCC(=CC1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C22H25FN6O3S/c1-14(2)33(30,31)28-8-5-15(6-9-28)17-11-24-22(29-13-26-27-21(17)29)25-12-18-16-7-10-32-20(16)4-3-19(18)23/h3-5,11,13-14H,6-10,12H2,1-2H3,(H,24,25)
PDB

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n/an/a 8.90n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498101
PNG
(US11013745, Compound E-Y19)
Show SMILES CCNC(=S)N1CCC(=CC1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C22H24FN7OS/c1-2-24-22(32)29-8-5-14(6-9-29)16-11-25-21(30-13-27-28-20(16)30)26-12-17-15-7-10-31-19(15)4-3-18(17)23/h3-5,11,13H,2,6-10,12H2,1H3,(H,24,32)(H,25,26)
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n/an/a 9.30n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498146
PNG
(US11013745, Compound E-Y13-H)
Show SMILES CS(=O)(=O)N1CCC(CC1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C20H23FN6O3S/c1-31(28,29)26-7-4-13(5-8-26)15-10-22-20(27-12-24-25-19(15)27)23-11-16-14-6-9-30-18(14)3-2-17(16)21/h2-3,10,12-13H,4-9,11H2,1H3,(H,22,23)
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n/an/a 10.7n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498138
PNG
(US11013745, Compound SL-ZYE-08)
Show SMILES Fc1ccc2OCCc2c1CNc1ncc(C2CCCOCC2)c2nncn12
Show InChI InChI=1S/C20H22FN5O2/c21-17-3-4-18-14(6-9-28-18)16(17)11-23-20-22-10-15(19-25-24-12-26(19)20)13-2-1-7-27-8-5-13/h3-4,10,12-13H,1-2,5-9,11H2,(H,22,23)
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n/an/a 11.9n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498131
PNG
(US11013745, Compound E-Y47)
Show SMILES Fc1ccc2OCCc2c1CNc1ncc(C2CCOCC2)c2nncn12
Show InChI InChI=1S/C19H20FN5O2/c20-16-1-2-17-13(5-8-27-17)15(16)10-22-19-21-9-14(12-3-6-26-7-4-12)18-24-23-11-25(18)19/h1-2,9,11-12H,3-8,10H2,(H,21,22)
PDB

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n/an/a 13n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498168
PNG
(US11013745, Compound SL-ZYE-196)
Show SMILES CC1CC(=CCO1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C20H20FN5O2/c1-12-8-13(4-6-27-12)15-9-22-20(26-11-24-25-19(15)26)23-10-16-14-5-7-28-18(14)3-2-17(16)21/h2-4,9,11-12H,5-8,10H2,1H3,(H,22,23)
PDB

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n/an/a 14.1n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498153
PNG
(US11013745, Compound SL-E25)
Show SMILES CN1CCC(CC1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C20H23FN6O/c1-26-7-4-13(5-8-26)15-10-22-20(27-12-24-25-19(15)27)23-11-16-14-6-9-28-18(14)3-2-17(16)21/h2-3,10,12-13H,4-9,11H2,1H3,(H,22,23)
PDB

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n/an/a 15n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498124
PNG
(US11013745, Compound E-Y40)
Show SMILES Fc1ccc2OCCc2c1CNc1ncc(C2=CCN(CC2)C(=O)CN2CCOCC2)c2nncn12
Show InChI InChI=1S/C25H28FN7O3/c26-21-1-2-22-18(5-10-36-22)20(21)14-28-25-27-13-19(24-30-29-16-33(24)25)17-3-6-32(7-4-17)23(34)15-31-8-11-35-12-9-31/h1-3,13,16H,4-12,14-15H2,(H,27,28)
PDB

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n/an/a 16.1n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498097
PNG
(US11013745, Compound E-Y16)
Show SMILES Fc1ccc2OCCc2c1CNc1ncc(C2=CCN(CC2)C(=O)c2ccccc2)c2nncn12
Show InChI InChI=1S/C26H23FN6O2/c27-22-6-7-23-19(10-13-35-23)21(22)15-29-26-28-14-20(24-31-30-16-33(24)26)17-8-11-32(12-9-17)25(34)18-4-2-1-3-5-18/h1-8,14,16H,9-13,15H2,(H,28,29)
PDB

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n/an/a 17.7n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498141
PNG
(US11013745, Compound SL-ZYE-11)
Show SMILES C(Nc1ncc(C2=CCOCC2)c2nncn12)c1cccc2OCCc12
Show InChI InChI=1S/C19H19N5O2/c1-2-14(15-6-9-26-17(15)3-1)10-20-19-21-11-16(13-4-7-25-8-5-13)18-23-22-12-24(18)19/h1-4,11-12H,5-10H2,(H,20,21)
PDB

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n/an/a 17.9n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498083
PNG
(US11013745, Compound E-Y1)
Show SMILES Fc1ccc2OCCc2c1CNc1ncc(C2=CCOCC2)c2nncn12
Show InChI InChI=1S/C19H18FN5O2/c20-16-1-2-17-13(5-8-27-17)15(16)10-22-19-21-9-14(12-3-6-26-7-4-12)18-24-23-11-25(18)19/h1-3,9,11H,4-8,10H2,(H,21,22)
PDB

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n/an/a 18n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498093
PNG
(US11013745, Compound E-Y13)
Show SMILES CS(=O)(=O)N1CCC(=CC1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C20H21FN6O3S/c1-31(28,29)26-7-4-13(5-8-26)15-10-22-20(27-12-24-25-19(15)27)23-11-16-14-6-9-30-18(14)3-2-17(16)21/h2-4,10,12H,5-9,11H2,1H3,(H,22,23)
PDB

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n/an/a 19n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498125
PNG
(US11013745, Compound E-Y41)
Show SMILES Fc1ccc2OCCc2c1CNc1ncc(C2=CCN(CC2)C(=O)c2cnco2)c2nncn12
Show InChI InChI=1S/C23H20FN7O3/c24-18-1-2-19-15(5-8-33-19)17(18)10-27-23-26-9-16(21-29-28-12-31(21)23)14-3-6-30(7-4-14)22(32)20-11-25-13-34-20/h1-3,9,11-13H,4-8,10H2,(H,26,27)
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n/an/a<20n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498100
PNG
(US11013745, Compound E-Y18)
Show SMILES CC(C)(C)NC(=O)N1CCC(=CC1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C24H28FN7O2/c1-24(2,3)29-23(33)31-9-6-15(7-10-31)17-12-26-22(32-14-28-30-21(17)32)27-13-18-16-8-11-34-20(16)5-4-19(18)25/h4-6,12,14H,7-11,13H2,1-3H3,(H,26,27)(H,29,33)
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n/an/a 21n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498167
PNG
(US11013745, Compound SL-ZYE-195)
Show SMILES CC1(C)CC(=CC(C)(C)O1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C23H26FN5O2/c1-22(2)9-14(10-23(3,4)31-22)16-11-25-21(29-13-27-28-20(16)29)26-12-17-15-7-8-30-19(15)6-5-18(17)24/h5-6,9,11,13H,7-8,10,12H2,1-4H3,(H,25,26)
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n/an/a 22.3n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498149
PNG
(US11013745, Compound SL-ZYE-28)
Show SMILES Fc1ccc2OCCc2c1CNc1ncc(C2=CCOc3ccccc23)c2nncn12
Show InChI InChI=1S/C23H18FN5O2/c24-19-5-6-21-16(8-10-31-21)17(19)11-25-23-26-12-18(22-28-27-13-29(22)23)14-7-9-30-20-4-2-1-3-15(14)20/h1-7,12-13H,8-11H2,(H,25,26)
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n/an/a 22.5n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498154
PNG
(US11013745, Compound SL-ZYE-119)
Show SMILES CC1(C)CC(=CCO1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C21H22FN5O2/c1-21(2)9-13(5-8-29-21)15-10-23-20(27-12-25-26-19(15)27)24-11-16-14-6-7-28-18(14)4-3-17(16)22/h3-5,10,12H,6-9,11H2,1-2H3,(H,23,24)
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n/an/a 23.3n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498120
PNG
(US11013745, Compound E-Y37)
Show SMILES Fc1ccc2OCCc2c1CNc1ncc(C2=CCN(CC2)C(=O)NCc2ccccc2)c2nncn12
Show InChI InChI=1S/C27H26FN7O2/c28-23-6-7-24-20(10-13-37-24)22(23)16-30-26-29-15-21(25-33-32-17-35(25)26)19-8-11-34(12-9-19)27(36)31-14-18-4-2-1-3-5-18/h1-8,15,17H,9-14,16H2,(H,29,30)(H,31,36)
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n/an/a 32.8n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498086
PNG
(US11013745, Compound E-Y3)
Show SMILES CC(C)(C)OC(=O)N1CCC(=CC1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C24H27FN6O3/c1-24(2,3)34-23(32)30-9-6-15(7-10-30)17-12-26-22(31-14-28-29-21(17)31)27-13-18-16-8-11-33-20(16)5-4-19(18)25/h4-6,12,14H,7-11,13H2,1-3H3,(H,26,27)
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n/an/a 37n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498159
PNG
(US11013745, Compound SL-ZYE-161)
Show SMILES CCC(=O)N1CCC(=CC1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C22H23FN6O2/c1-2-20(30)28-8-5-14(6-9-28)16-11-24-22(29-13-26-27-21(16)29)25-12-17-15-7-10-31-19(15)4-3-18(17)23/h3-5,11,13H,2,6-10,12H2,1H3,(H,24,25)
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n/an/a 40.8n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498147
PNG
(US11013745, Compound SL-ZYE-23)
Show SMILES CC1CC(=CC(C)N1C(=O)OC(C)(C)C)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C26H31FN6O3/c1-15-10-17(11-16(2)33(15)25(34)36-26(3,4)5)19-12-28-24(32-14-30-31-23(19)32)29-13-20-18-8-9-35-22(18)7-6-21(20)27/h6-7,10,12,14-16H,8-9,11,13H2,1-5H3,(H,28,29)
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n/an/a 47.6n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498123
PNG
(US11013745, Compound E-Y39)
Show SMILES Fc1ccc2OCCc2c1CNc1ncc(C2=CCN(CC2)C(=S)NC(=O)c2ccccc2)c2nncn12
Show InChI InChI=1S/C27H24FN7O2S/c28-22-6-7-23-19(10-13-37-23)21(22)15-30-26-29-14-20(24-33-31-16-35(24)26)17-8-11-34(12-9-17)27(38)32-25(36)18-4-2-1-3-5-18/h1-8,14,16H,9-13,15H2,(H,29,30)(H,32,36,38)
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n/an/a 54.5n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498143
PNG
(US11013745, Compound SL-ZYE-17)
Show SMILES C(Nc1ncc(C2=CCOCC2)c2nncn12)c1cccc2occc12
Show InChI InChI=1S/C19H17N5O2/c1-2-14(15-6-9-26-17(15)3-1)10-20-19-21-11-16(13-4-7-25-8-5-13)18-23-22-12-24(18)19/h1-4,6,9,11-12H,5,7-8,10H2,(H,20,21)
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n/an/a 56n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498122
PNG
(US11013745, Compound E-Y38)
Show SMILES Fc1ccc2OCCc2c1CNC1=NC=C(C2=CCN(CC2)C(=O)Nc2ccc(Cl)cc2)[C]=2=[N]1C=NN=2
Show InChI InChI=1S/C26H23ClFN7O2/c27-17-1-3-18(4-2-17)32-26(36)34-10-7-16(8-11-34)20-13-29-25(35-15-31-33-24(20)35)30-14-21-19-9-12-37-23(19)6-5-22(21)28/h1-7,13,15H,8-12,14H2,(H,29,30)(H,32,36)
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n/an/a 58.5n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498142
PNG
(US11013745, Compound SL-ZYE-14)
Show SMILES C(Nc1ncc(C2CCOCC2)c2nncn12)c1cccc2OCCc12
Show InChI InChI=1S/C19H21N5O2/c1-2-14(15-6-9-26-17(15)3-1)10-20-19-21-11-16(13-4-7-25-8-5-13)18-23-22-12-24(18)19/h1-3,11-13H,4-10H2,(H,20,21)
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n/an/a 84n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498128
PNG
(US11013745, Compound E-Y44)
Show SMILES Fc1ccc2OCCc2c1CNc1ncc(C2=CCN(CC2)C(=O)OCc2ccccc2)c2nncn12
Show InChI InChI=1S/C27H25FN6O3/c28-23-6-7-24-20(10-13-36-24)22(23)15-30-26-29-14-21(25-32-31-17-34(25)26)19-8-11-33(12-9-19)27(35)37-16-18-4-2-1-3-5-18/h1-8,14,17H,9-13,15-16H2,(H,29,30)
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n/an/a 85.8n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498111
PNG
(US11013745, Compound E-Y26)
Show SMILES Cc1ccc(NC(=O)N2CCC(=CC2)c2cnc(NCc3ccco3)n3cnnc23)cc1
Show InChI InChI=1S/C23H23N7O2/c1-16-4-6-18(7-5-16)27-23(31)29-10-8-17(9-11-29)20-14-25-22(30-15-26-28-21(20)30)24-13-19-3-2-12-32-19/h2-8,12,14-15H,9-11,13H2,1H3,(H,24,25)(H,27,31)
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n/an/a 91n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498112
PNG
(US11013745, Compound E-Y27)
Show SMILES Clc1ccc(NC(=O)N2CCC(=CC2)C2=CN=C(NCc3ccco3)[N]3=[C]2=NN=C3)cc1
Show InChI InChI=1S/C22H20ClN7O2/c23-16-3-5-17(6-4-16)27-22(31)29-9-7-15(8-10-29)19-13-25-21(30-14-26-28-20(19)30)24-12-18-2-1-11-32-18/h1-7,11,13-14H,8-10,12H2,(H,24,25)(H,27,31)
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n/an/a 92n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498145
PNG
(US11013745, Compound E-Y20-H)
Show SMILES CC(=O)N1CCC(CC1)c1cnc(NCc2ccco2)n2cnnc12
Show InChI InChI=1S/C17H20N6O2/c1-12(24)22-6-4-13(5-7-22)15-10-19-17(23-11-20-21-16(15)23)18-9-14-3-2-8-25-14/h2-3,8,10-11,13H,4-7,9H2,1H3,(H,18,19)
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n/an/a 93.9n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498095
PNG
(US11013745, Compound E-Y14)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCC(=CC1)c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
Show InChI InChI=1S/C26H25FN6O3S/c1-17-2-4-19(5-3-17)37(34,35)32-11-8-18(9-12-32)21-14-28-26(33-16-30-31-25(21)33)29-15-22-20-10-13-36-24(20)7-6-23(22)27/h2-8,14,16H,9-13,15H2,1H3,(H,28,29)
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n/an/a 101n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM225230
PNG
(EED226 | US11013745, Compound EED226)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cnc(NCc2ccco2)n2cnnc12
Show InChI InChI=1S/C17H15N5O3S/c1-26(23,24)14-6-4-12(5-7-14)15-10-19-17(22-11-20-21-16(15)22)18-9-13-3-2-8-25-13/h2-8,10-11H,9H2,1H3,(H,18,19)
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n/an/a 104n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498113
PNG
(US11013745, Compound E-Y28)
Show SMILES O=C(NCc1ccccc1)N1CCC(=CC1)c1cnc(NCc2ccco2)n2cnnc12
Show InChI InChI=1S/C23H23N7O2/c31-23(26-13-17-5-2-1-3-6-17)29-10-8-18(9-11-29)20-15-25-22(30-16-27-28-21(20)30)24-14-19-7-4-12-32-19/h1-8,12,15-16H,9-11,13-14H2,(H,24,25)(H,26,31)
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n/an/a 107n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498144
PNG
(US11013745, Compound SL-ZYE-18)
Show SMILES CC(C)(C)OC(=O)N1CCC(=CC1)c1cnc(NCc2cccc3occc23)n2cnnc12
Show InChI InChI=1S/C24H26N6O3/c1-24(2,3)33-23(31)29-10-7-16(8-11-29)19-14-26-22(30-15-27-28-21(19)30)25-13-17-5-4-6-20-18(17)9-12-32-20/h4-7,9,12,14-15H,8,10-11,13H2,1-3H3,(H,25,26)
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n/an/a 115n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498102
PNG
(US11013745, Compound E-Y20)
Show SMILES CC(=O)N1CCC(=CC1)c1cnc(NCc2ccco2)n2cnnc12
Show InChI InChI=1S/C17H18N6O2/c1-12(24)22-6-4-13(5-7-22)15-10-19-17(23-11-20-21-16(15)23)18-9-14-3-2-8-25-14/h2-4,8,10-11H,5-7,9H2,1H3,(H,18,19)
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n/an/a 166n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498135
PNG
(US11013745, Compound E-Y51)
Show SMILES CC(C)(C)OC(=O)N1CCC(=CC1)c1cc(C#N)c(NCc2ccco2)n2cnnc12
Show InChI InChI=1S/C22H24N6O3/c1-22(2,3)31-21(29)27-8-6-15(7-9-27)18-11-16(12-23)19(28-14-25-26-20(18)28)24-13-17-5-4-10-30-17/h4-6,10-11,14,24H,7-9,13H2,1-3H3
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n/an/a 200n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498109
PNG
(US11013745, Compound E-Y24)
Show SMILES CCNC(=O)N1CCC(=CC1)c1cnc(NCc2ccco2)n2cnnc12
Show InChI InChI=1S/C18H21N7O2/c1-2-19-18(26)24-7-5-13(6-8-24)15-11-21-17(25-12-22-23-16(15)25)20-10-14-4-3-9-27-14/h3-5,9,11-12H,2,6-8,10H2,1H3,(H,19,26)(H,20,21)
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n/an/a 204n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498092
PNG
(US11013745, Compound E-Y10)
Show SMILES Fc1ccc2OCCc2c1CNc1ncc(C2=CCNCC2)c2nncn12
Show InChI InChI=1S/C19H19FN6O/c20-16-1-2-17-13(5-8-27-17)15(16)10-23-19-22-9-14(12-3-6-21-7-4-12)18-25-24-11-26(18)19/h1-3,9,11,21H,4-8,10H2,(H,22,23)
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n/an/a 218n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498130
PNG
(US11013745, Compound E-Y46)
Show SMILES CC(C)(C)OC(=O)N1CCC(=CC1)c1cnc(NCc2cccs2)n2cnnc12
Show InChI InChI=1S/C20H24N6O2S/c1-20(2,3)28-19(27)25-8-6-14(7-9-25)16-12-22-18(26-13-23-24-17(16)26)21-11-15-5-4-10-29-15/h4-6,10,12-13H,7-9,11H2,1-3H3,(H,21,22)
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n/an/a 296n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498091
PNG
(US11013745, Compound E-Y6)
Show SMILES CC(C)(C)OC(=O)N1CCC(=CC1)c1cnc(NCc2ccco2)n2cnnc12
Show InChI InChI=1S/C20H24N6O3/c1-20(2,3)29-19(27)25-8-6-14(7-9-25)16-12-22-18(26-13-23-24-17(16)26)21-11-15-5-4-10-28-15/h4-6,10,12-13H,7-9,11H2,1-3H3,(H,21,22)
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n/an/a 307n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498118
PNG
(US11013745, Compound E-Y35)
Show SMILES CN(C)CC(=O)N1CCC(=CC1)c1cnc(NCc2ccco2)n2cnnc12
Show InChI InChI=1S/C19H23N7O2/c1-24(2)12-17(27)25-7-5-14(6-8-25)16-11-21-19(26-13-22-23-18(16)26)20-10-15-4-3-9-28-15/h3-5,9,11,13H,6-8,10,12H2,1-2H3,(H,20,21)
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n/an/a 318n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498106
PNG
(US11013745, Compound E-Y22)
Show SMILES CS(=O)(=O)N1CCC(=CC1)c1cnc(NCc2ccco2)n2cnnc12
Show InChI InChI=1S/C16H18N6O3S/c1-26(23,24)21-6-4-12(5-7-21)14-10-18-16(22-11-19-20-15(14)22)17-9-13-3-2-8-25-13/h2-4,8,10-11H,5-7,9H2,1H3,(H,17,18)
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n/an/a 334n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498116
PNG
(US11013745, Compound E-Y32)
Show SMILES CS(=O)(=O)NC1CCC(=CC1)c1cnc(NCc2ccco2)n2cnnc12
Show InChI InChI=1S/C17H20N6O3S/c1-27(24,25)22-13-6-4-12(5-7-13)15-10-19-17(23-11-20-21-16(15)23)18-9-14-3-2-8-26-14/h2-4,8,10-11,13,22H,5-7,9H2,1H3,(H,18,19)
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n/an/a 342n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498107
PNG
(US11013745, Compound E-Y23)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCC(=CC1)c1cnc(NCc2ccco2)n2cnnc12
Show InChI InChI=1S/C22H22N6O3S/c1-16-4-6-19(7-5-16)32(29,30)27-10-8-17(9-11-27)20-14-24-22(28-15-25-26-21(20)28)23-13-18-3-2-12-31-18/h2-8,12,14-15H,9-11,13H2,1H3,(H,23,24)
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n/an/a 350n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498104
PNG
(US11013745, Compound E-Y21)
Show SMILES O=C(N1CCC(=CC1)c1cnc(NCc2ccco2)n2cnnc12)c1ccccc1
Show InChI InChI=1S/C22H20N6O2/c29-21(17-5-2-1-3-6-17)27-10-8-16(9-11-27)19-14-24-22(28-15-25-26-20(19)28)23-13-18-7-4-12-30-18/h1-8,12,14-15H,9-11,13H2,(H,23,24)
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n/an/a 351n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498110
PNG
(US11013745, Compound E-Y25)
Show SMILES CC(C)(C)NC(=O)N1CCC(=CC1)c1cnc(NCc2ccco2)n2cnnc12
Show InChI InChI=1S/C20H25N7O2/c1-20(2,3)24-19(28)26-8-6-14(7-9-26)16-12-22-18(27-13-23-25-17(16)27)21-11-15-5-4-10-29-15/h4-6,10,12-13H,7-9,11H2,1-3H3,(H,21,22)(H,24,28)
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n/an/a 373n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498087
PNG
(US11013745, Compound E-Y4)
Show SMILES C(Nc1ncc(C2=CCOCC2)c2nncn12)c1ccco1
Show InChI InChI=1S/C15H15N5O2/c1-2-12(22-5-1)8-16-15-17-9-13(11-3-6-21-7-4-11)14-19-18-10-20(14)15/h1-3,5,9-10H,4,6-8H2,(H,16,17)
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n/an/a 511n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498119
PNG
(US11013745, Compound E-Y36)
Show SMILES O=C(CN1CCOCC1)N1CCC(=CC1)c1cnc(NCc2ccco2)n2cnnc12
Show InChI InChI=1S/C21H25N7O3/c29-19(14-26-7-10-30-11-8-26)27-5-3-16(4-6-27)18-13-23-21(28-15-24-25-20(18)28)22-12-17-2-1-9-31-17/h1-3,9,13,15H,4-8,10-12,14H2,(H,22,23)
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n/an/a 543n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498089
PNG
(US11013745, Compound E-Y5)
Show SMILES C(Nc1ncc(C2=CCSCC2)c2nncn12)c1ccco1
Show InChI InChI=1S/C15H15N5OS/c1-2-12(21-5-1)8-16-15-17-9-13(11-3-6-22-7-4-11)14-19-18-10-20(14)15/h1-3,5,9-10H,4,6-8H2,(H,16,17)
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n/an/a 611n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498115
PNG
(US11013745, Compound E-Y31)
Show SMILES O=C(NC1CCC(=CC1)c1cnc(NCc2ccco2)n2cnnc12)c1ccccc1
Show InChI InChI=1S/C23H22N6O2/c30-22(17-5-2-1-3-6-17)27-18-10-8-16(9-11-18)20-14-25-23(29-15-26-28-21(20)29)24-13-19-7-4-12-31-19/h1-8,12,14-15,18H,9-11,13H2,(H,24,25)(H,27,30)
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n/an/a 758n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498114
PNG
(US11013745, Compound E-Y30)
Show SMILES CC(=O)NC1CCC(=CC1)c1cnc(NCc2ccco2)n2cnnc12
Show InChI InChI=1S/C18H20N6O2/c1-12(25)22-14-6-4-13(5-7-14)16-10-20-18(24-11-21-23-17(16)24)19-9-15-3-2-8-26-15/h2-4,8,10-11,14H,5-7,9H2,1H3,(H,19,20)(H,22,25)
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n/an/a 793n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
Polycomb Repressive Complex 2 (PRC2)


(Homo sapiens (Human))
BDBM498117
PNG
(US11013745, Compound E-Y34)
Show SMILES CC(F)(F)C(=O)N1CCC(=CC1)c1cnc(NCc2ccco2)n2cnnc12
Show InChI InChI=1S/C18H18F2N6O2/c1-18(19,20)16(27)25-6-4-12(5-7-25)14-10-22-17(26-11-23-24-15(14)26)21-9-13-3-2-8-28-13/h2-4,8,10-11H,5-7,9H2,1H3,(H,21,22)
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n/an/a 907n/an/an/an/an/an/a



SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; SUZHOU SUPLEAD LIFE SCIENCES CO., LTD.

US Patent


Assay Description
The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...


US Patent US11013745 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%