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Patent code US11014911

Compile Data Set for Download or QSAR

Found 1035 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498218
PNG
(US11014911, Example 43)
Show SMILES CC[C@H](C)NC(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)c2ccnc3ncsc23)n[nH]1
PDB

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US Patent
0.0400n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498217
PNG
(US11014911, Example 42)
Show SMILES CC[C@H](C)NC(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)c2ccnn2C)n[nH]1
PDB

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0.0500n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498324
PNG
(US11014911, Example 149)
Show SMILES COc1cc(CC(=O)Nc2cc([nH]n2)[C@H]2CC[C@H](C2)OC(=O)N2[C@@H](C)C[C@@H]2C)ccn1
PDB

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0.0600n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498321
PNG
(US11014911, Example 146)
Show SMILES COc1cc(CC(=O)Nc2cc([nH]n2)[C@H]2CC[C@H](C2)OC(=O)N2CCC2(C)C)ccn1
PDB

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0.0700n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498778
PNG
((1R,3S)-3-(3-{[(3-methyl-1,2- oxazol-5-yl)acetyl]...)
Show SMILES CCC1(C)CCN1C(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)Cc2cc(C)no2)n[nH]1
PDB

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0.0700n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498778
PNG
((1R,3S)-3-(3-{[(3-methyl-1,2- oxazol-5-yl)acetyl]...)
Show SMILES CCC1(C)CCN1C(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)Cc2cc(C)no2)n[nH]1
PDB

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0.0800n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498295
PNG
(US11014911, Example 120 | US11014911, Example 121)
Show SMILES CC1(CCOC1)NC(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)Cc2cc(F)cc(F)c2)n[nH]1
PDB

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Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498316
PNG
(US11014911, Example 141)
Show SMILES C[C@H]1CCCN1C(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)Cc2cnc3ncnn3c2)n[nH]1
PDB

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Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498266
PNG
(US11014911, Example 91)
Show SMILES C[C@@H](CC(F)(F)F)NC(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)c2cnnn2C)n[nH]1
PDB

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Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498295
PNG
(US11014911, Example 120 | US11014911, Example 121)
Show SMILES CC1(CCOC1)NC(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)Cc2cc(F)cc(F)c2)n[nH]1
PDB

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Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498312
PNG
(US11014911, Example 137)
Show SMILES CC1(C)CCCN1C(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)Cc2cnc3ncnn3c2)n[nH]1
PDB

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Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498273
PNG
(US11014911, Example 98 | US11014911, Example 99)
Show SMILES COc1cc(CC(=O)Nc2cc([nH]n2)[C@H]2CC[C@H](C2)OC(=O)NC(C)CC(F)F)ccn1
PDB

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0.0900n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498258
PNG
(US11014911, Example 83 | US11014911, Example 84)
Show SMILES CC(CC(F)(F)F)NC(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)Cc2cnco2)n[nH]1
PDB

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Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498267
PNG
(US11014911, Example 92)
Show SMILES C[C@@H](CC(F)(F)F)NC(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)Cc2cnn(C)c2)n[nH]1
PDB

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Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498250
PNG
(US11014911, Example 75 | US11014911, Example 76)
Show SMILES CC(CC(F)(F)F)NC(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)Cc2ccc(C)nc2)n[nH]1
PDB

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Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498228
PNG
(US11014911, Example 53)
Show SMILES CC[C@H](C)NC(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)c2ccnn2CCO)n[nH]1
PDB

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Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498175
PNG
(US11014911, Example 4)
Show SMILES CC[C@H](C)NC(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)c2cnnn2C)n[nH]1
PDB

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Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498230
PNG
(US11014911, Example 55)
Show SMILES CC(C)NC(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)Cc2ccc3n(C)ncc3c2)n[nH]1
PDB

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Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498319
PNG
(US11014911, Example 144)
Show SMILES COc1ccc(CC(=O)Nc2cc([nH]n2)[C@H]2CC[C@H](C2)OC(=O)N2CCC2(C)C)cn1
PDB

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Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498220
PNG
(US11014911, Example 45)
Show SMILES CC[C@H](C)NC(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)Cc2ccc(C)cc2S(C)(=O)=O)n[nH]1
PDB

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0.110n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498308
PNG
(US11014911, Example 133)
Show SMILES Cc1cc(CC(=O)Nc2cc([nH]n2)[C@H]2CC[C@H](C2)OC(=O)N2CCCCC2(C)C)on1
PDB

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0.110n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498236
PNG
(US11014911, Example 61)
Show SMILES CCC(C)(C)NC(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)Cc2cnn(C)c2)n[nH]1
PDB

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0.110n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498198
PNG
(US11014911, Example 23)
Show SMILES CCCNC(=O)O[C@H]1CC[C@H](C1)c1cc(NC(=O)Cc2ccc3[nH]c(C)nc3c2)n[nH]1
PDB

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0.110n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498222
PNG
(US11014911, Example 47)
Show SMILES CC[C@H](C)NC(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)Cc2ccc3nc(C)cn3n2)n[nH]1
PDB

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0.110n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498309
PNG
(US11014911, Example 134)
Show SMILES Cc1cc(CC(=O)Nc2cc([nH]n2)[C@H]2CC[C@H](C2)OC(=O)N2CCCC2(C)C)on1
PDB

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0.120n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498320
PNG
(US11014911, Example 145)
Show SMILES COc1ccc(CC(=O)Nc2cc([nH]n2)[C@@H]2CC[C@@H](C2)OC(=O)N2CCC2(C)C)cn1
PDB

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Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498291
PNG
(US11014911, Example 116)
Show SMILES Cc1ncc(CC(=O)Nc2cc([nH]n2)[C@H]2CC[C@H](C2)OC(=O)NC2(C)CCCC2)s1
PDB

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0.130n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498294
PNG
(US11014911, Example 119)
Show SMILES Cn1cc(CC(=O)Nc2cc([nH]n2)[C@H]2CC[C@H](C2)OC(=O)NC2(C)CCC2)cn1
PDB

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0.130n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498330
PNG
(US11014911, Example 155 | US11014911, Example 156)
Show SMILES COc1cc(CC(=O)Nc2cc([nH]n2)[C@H]2CC[C@H](C2)OC(=O)N2C[C@@H](C#N)[C@@H]2C)ccn1
PDB

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0.130n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498184
PNG
(US11014911, Example 12)
Show SMILES Cc1cc(CC(=O)Nc2cc([nH]n2)[C@H]2CC[C@H](C2)OC(=O)N2CCC2(C)C)on1
PDB

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0.130n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498297
PNG
(US11014911, Example 122 | US11014911, Example 123)
Show SMILES COc1ccc(CC(=O)Nc2cc([nH]n2)[C@H]2CC[C@H](C2)OC(=O)NC2(C)CCOC2)cn1
PDB

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0.130n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498214
PNG
(US11014911, Example 39)
Show SMILES CC[C@H](C)NC(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)Cc2cnc3ncnn3c2)n[nH]1
PDB

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Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498238
PNG
(US11014911, Example 63 | US11014911, Example 64)
Show SMILES CC(CC(F)(F)F)NC(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)Cc2ccon2)n[nH]1
PDB

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Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498292
PNG
(US11014911, Example 117)
Show SMILES CC1(CCCC1)NC(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)Cc2ccno2)n[nH]1
PDB

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Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498246
PNG
(US11014911, Example 71 | US11014911, Example 72)
Show SMILES CC(CC(F)(F)F)NC(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)Cc2cc(C)no2)n[nH]1
PDB

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0.150n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498334
PNG
(US11014911, Example 159 | US11014911, Example 160)
Show SMILES C[C@H]1[C@@H](CN1C(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)Cc2cnc(C)s2)n[nH]1)C#N
PDB

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0.150n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498336
PNG
(US11014911, Example 161 | US11014911, Example 162)
Show SMILES C[C@H]1[C@@H](CN1C(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)Cc2ccccc2)n[nH]1)C#N
PDB

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Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498269
PNG
(US11014911, Example 94)
Show SMILES COc1cc(C(=O)Nc2cc([nH]n2)[C@H]2CC[C@H](C2)OC(=O)N[C@@H](C)CC(F)(F)F)n(C)n1
PDB

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Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498283
PNG
(US11014911, Example 108)
Show SMILES CC(C)(C)NC(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)Cc2ccno2)n[nH]1
PDB

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Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498234
PNG
(US11014911, Example 59)
Show SMILES COc1ccc(CC(=O)Nc2cc([nH]n2)[C@H]2CC[C@H](C2)OC(=O)N(C)C(C)C)cn1
PDB

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Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498326
PNG
(US11014911, Example 151 | US11014911, Example 152)
Show SMILES COc1ccc(CC(=O)Nc2cc([nH]n2)[C@H]2CC[C@H](C2)OC(=O)N2CCC2C)cn1
PDB

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Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498254
PNG
(US11014911, Example 79 | US11014911, Example 80)
Show SMILES CC(CC(F)(F)F)NC(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)Cc2cnc(C)s2)n[nH]1
PDB

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Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498287
PNG
(US11014911, Example 112)
Show SMILES Cn1cc(CC(=O)Nc2cc([nH]n2)[C@H]2CC[C@H](C2)OC(=O)NC(C)(C)C)cn1
PDB

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Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498303
PNG
(US11014911, Example 128)
Show SMILES CC1(CC1)NC(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)Cc2ccno2)n[nH]1
PDB

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0.150n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498262
PNG
(US11014911, Example 87 | US11014911, Example 88)
Show SMILES COCCn1nccc1C(=O)Nc1cc([nH]n1)[C@H]1CC[C@H](C1)OC(=O)NC(C)CC(F)(F)F
PDB

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Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498252
PNG
(US11014911, Example 77 | US11014911, Example 78)
Show SMILES COc1cc(CC(=O)Nc2cc([nH]n2)[C@H]2CC[C@H](C2)OC(=O)NC(C)CC(F)(F)F)ccn1
PDB

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Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498206
PNG
(US11014911, Example 31)
Show SMILES CC[C@H](C)NC(=O)O[C@H]1CC[C@H](C1)c1cc(NC(=O)c2cnnn2C)n[nH]1
PDB

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0.160n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498204
PNG
(US11014911, Example 29)
Show SMILES CC[C@@H](C)NC(=O)O[C@H]1CC[C@H](C1)c1cc(NC(=O)Cc2ccno2)n[nH]1
PDB

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0.160n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498288
PNG
(US11014911, Example 113)
Show SMILES Cc1ncc(CC(=O)Nc2cc([nH]n2)[C@H]2CC[C@H](C2)OC(=O)NC(C)(C)C)s1
PDB

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0.160n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM498205
PNG
(US11014911, Example 30)
Show SMILES CC[C@H](C)NC(=O)O[C@H]1CC[C@H](C1)c1cc(NC(=O)Cc2ccno2)n[nH]1
PDB

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0.160n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...


US Patent US11014911 (2021)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%