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Patent code US11014912

Compile Data Set for Download or QSAR
Found 68 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498874
PNG
(US11014912, Example 50)
Show SMILES C[C@@H]([C@@H]1CCN(C1)C#N)C(=O)Nc1cc(no1)-c1cccc(Cl)c1
Show InChI InChI=1S/C17H17ClN4O2/c1-11(13-5-6-22(9-13)10-19)17(23)20-16-8-15(21-24-16)12-3-2-4-14(18)7-12/h2-4,7-8,11,13H,5-6,9H2,1H3,(H,20,23)/t11-,13+/m0/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498879
PNG
(US11014912, Example 55)
Show SMILES O=C(C[C@H]1CCN(C1)C#N)Nc1cc(on1)-c1cccc(c1)C#N
Show InChI InChI=1S/C17H15N5O2/c18-9-12-2-1-3-14(6-12)15-8-16(21-24-15)20-17(23)7-13-4-5-22(10-13)11-19/h1-3,6,8,13H,4-5,7,10H2,(H,20,21,23)/t13-/m1/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498875
PNG
(US11014912, Example 51)
Show SMILES O=C(C[C@H]1CCN(C1)C#N)Nc1cc(no1)-c1cccc(c1)C#N
Show InChI InChI=1S/C17H15N5O2/c18-9-12-2-1-3-14(6-12)15-8-17(24-21-15)20-16(23)7-13-4-5-22(10-13)11-19/h1-3,6,8,13H,4-5,7,10H2,(H,20,23)/t13-/m1/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498860
PNG
((R)—N-(3-(3-Chlorophenyl)isoxazol-5-yl)-2-(1-...)
Show SMILES Clc1cccc(c1)-c1cc(NC(=O)C[C@H]2CCN(C2)C#N)on1
Show InChI InChI=1S/C16H15ClN4O2/c17-13-3-1-2-12(7-13)14-8-16(23-20-14)19-15(22)6-11-4-5-21(9-11)10-18/h1-3,7-8,11H,4-6,9H2,(H,19,22)/t11-/m1/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498878
PNG
(US11014912, Example 54)
Show SMILES FC(F)(F)Oc1cccc(c1)-c1cc(NC(=O)C[C@H]2CCN(C2)C#N)on1
Show InChI InChI=1S/C17H15F3N4O3/c18-17(19,20)26-13-3-1-2-12(7-13)14-8-16(27-23-14)22-15(25)6-11-4-5-24(9-11)10-21/h1-3,7-8,11H,4-6,9H2,(H,22,25)/t11-/m1/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498862
PNG
(US11014912, Example 38)
Show SMILES COc1ccc(cc1)C1CN(C1)C(=O)C[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C17H21N3O2/c1-22-16-4-2-14(3-5-16)15-10-20(11-15)17(21)8-13-6-7-19(9-13)12-18/h2-5,13,15H,6-11H2,1H3/t13-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498889
PNG
(US11014912, Example 67)
Show SMILES COc1ccc(cc1-c1cnn(C)c1)C1CN(C1)C(=O)C[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C21H25N5O2/c1-24-11-17(9-23-24)19-8-16(3-4-20(19)28-2)18-12-26(13-18)21(27)7-15-5-6-25(10-15)14-22/h3-4,8-9,11,15,18H,5-7,10,12-13H2,1-2H3/t15-/m0/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498863
PNG
((S)-3-(2-(3-(4-Methoxy-3-(1H-pyrazol-5-yl)phenyl)a...)
Show SMILES COc1ccc(cc1-c1ccnn1C(=O)OC(C)(C)C)C1CN(C1)C(=O)C[C@@H]1CCN(C1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C29H40N4O6/c1-28(2,3)38-26(35)31-13-11-19(16-31)14-25(34)32-17-21(18-32)20-8-9-24(37-7)22(15-20)23-10-12-30-33(23)27(36)39-29(4,5)6/h8-10,12,15,19,21H,11,13-14,16-18H2,1-7H3/t19-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498877
PNG
(US11014912, Example 53)
Show SMILES C[C@H]([C@@H]1CCN(C1)C#N)C(=O)Nc1cc(no1)-c1cccc(Cl)c1
Show InChI InChI=1S/C17H17ClN4O2/c1-11(13-5-6-22(9-13)10-19)17(23)20-16-8-15(21-24-16)12-3-2-4-14(18)7-12/h2-4,7-8,11,13H,5-6,9H2,1H3,(H,20,23)/t11-,13-/m1/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498846
PNG
(2-(1-Cyanopyrrolidin-3- ylidene)-N-(4- phenoxyphen...)
Show SMILES O=C(Nc1ccc(Oc2ccccc2)cc1)C=C1CCN(C1)C#N
Show InChI InChI=1S/C19H17N3O2/c20-14-22-11-10-15(13-22)12-19(23)21-16-6-8-18(9-7-16)24-17-4-2-1-3-5-17/h1-9,12H,10-11,13H2,(H,21,23)/b15-12-
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498867
PNG
(US11014912, Example 43)
Show SMILES COc1cccc(c1)-c1cc(NC(=O)C[C@H]2CCN(C2)C#N)on1
Show InChI InChI=1S/C17H18N4O3/c1-23-14-4-2-3-13(8-14)15-9-17(24-20-15)19-16(22)7-12-5-6-21(10-12)11-18/h2-4,8-9,12H,5-7,10H2,1H3,(H,19,22)/t12-/m1/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498890
PNG
(US11014912, Example 68)
Show SMILES COc1cccc(C2CN(C2)C(=O)C[C@@H]2CCN(C2)C#N)c1F
Show InChI InChI=1S/C17H20FN3O2/c1-23-15-4-2-3-14(17(15)18)13-9-21(10-13)16(22)7-12-5-6-20(8-12)11-19/h2-4,12-13H,5-10H2,1H3/t12-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498883
PNG
(US11014912, Example 59)
Show SMILES Cc1cc(ccc1C#N)C1CN(C1)C(=O)C[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C18H20N4O/c1-13-6-15(2-3-16(13)8-19)17-10-22(11-17)18(23)7-14-4-5-21(9-14)12-20/h2-3,6,14,17H,4-5,7,9-11H2,1H3/t14-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498864
PNG
((S)-3-(2-(3-(4-Methoxy-3-(1-methyl-1H-pyrazol-5-yl...)
Show SMILES COc1ccc(cc1-c1ccnn1C)C1CN(C1)C(=O)C[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C21H25N5O2/c1-24-19(5-7-23-24)18-10-16(3-4-20(18)28-2)17-12-26(13-17)21(27)9-15-6-8-25(11-15)14-22/h3-5,7,10,15,17H,6,8-9,11-13H2,1-2H3/t15-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498866
PNG
(US11014912, Example 42)
Show SMILES Clc1cccc(c1)-c1cc(NC(=O)C[C@@H]2CCN(C2)C#N)on1
Show InChI InChI=1S/C16H15ClN4O2/c17-13-3-1-2-12(7-13)14-8-16(23-20-14)19-15(22)6-11-4-5-21(9-11)10-18/h1-3,7-8,11H,4-6,9H2,(H,19,22)/t11-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498856
PNG
(N-(Benzo[d]thiazol-2-yl)-2-(1- cyanopyrrolidin-3-y...)
Show SMILES CN(C(=O)C=C1CCN(C1)C#N)c1nc2ccccc2s1
Show InChI InChI=1S/C15H14N4OS/c1-18(14(20)8-11-6-7-19(9-11)10-16)15-17-12-4-2-3-5-13(12)21-15/h2-5,8H,6-7,9H2,1H3/b11-8+
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498857
PNG
(2-(1-Cyanopyrrolidin-3- ylidene)-N-(3,4- dichlorob...)
Show SMILES CN(Cc1ccc(Cl)c(Cl)c1)C(=O)C=C1CCN(C1)C#N
Show InChI InChI=1S/C15H15Cl2N3O/c1-19(8-11-2-3-13(16)14(17)6-11)15(21)7-12-4-5-20(9-12)10-18/h2-3,6-7H,4-5,8-9H2,1H3/b12-7-
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498859
PNG
((R)—N-(3-(4-Chlorophenyl)isoxazol-5-yl)-2-(1-...)
Show SMILES Clc1ccc(cc1)-c1cc(NC(=O)C[C@H]2CCN(C2)C#N)on1
Show InChI InChI=1S/C16H15ClN4O2/c17-13-3-1-12(2-4-13)14-8-16(23-20-14)19-15(22)7-11-5-6-21(9-11)10-18/h1-4,8,11H,5-7,9H2,(H,19,22)/t11-/m1/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498865
PNG
(US11014912, Example 41)
Show SMILES O=C(CC1CCN(C1)C#N)Nc1nnc(s1)-c1ccccc1
Show InChI InChI=1S/C15H15N5OS/c16-10-20-7-6-11(9-20)8-13(21)17-15-19-18-14(22-15)12-4-2-1-3-5-12/h1-5,11H,6-9H2,(H,17,19,21)
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498876
PNG
(US11014912, Example 52)
Show SMILES O=C(C[C@@H]1CCN(C1)C#N)N1CC(C1)c1ccc(cc1)C#N
Show InChI InChI=1S/C17H18N4O/c18-8-13-1-3-15(4-2-13)16-10-21(11-16)17(22)7-14-5-6-20(9-14)12-19/h1-4,14,16H,5-7,9-11H2/t14-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498881
PNG
(US11014912, Example 57)
Show SMILES O=C(C[C@@H]1CCN(C1)C#N)N1CC(C1)c1ccc(cn1)C#N
Show InChI InChI=1S/C16H17N5O/c17-6-13-1-2-15(19-7-13)14-9-21(10-14)16(22)5-12-3-4-20(8-12)11-18/h1-2,7,12,14H,3-5,8-10H2/t12-/m0/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498884
PNG
(US11014912, Example 60)
Show SMILES CN(C)C(=O)c1ccc(cc1)C1CN(C1)C(=O)C[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C19H24N4O2/c1-21(2)19(25)16-5-3-15(4-6-16)17-11-23(12-17)18(24)9-14-7-8-22(10-14)13-20/h3-6,14,17H,7-12H2,1-2H3/t14-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498827
PNG
(2-(1-Cyanopyrrolidin-3-yl)-N-(6- methoxybenzo[d]th...)
Show SMILES COc1ccc2nc(NC(=O)CC3CCN(C3)C#N)sc2c1
Show InChI InChI=1S/C15H16N4O2S/c1-21-11-2-3-12-13(7-11)22-15(17-12)18-14(20)6-10-4-5-19(8-10)9-16/h2-3,7,10H,4-6,8H2,1H3,(H,17,18,20)
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498849
PNG
(2-(1-Cyanopyrrolidin-3- ylidene)-N-methyl-N-((5- p...)
Show SMILES CN(Cc1cc(on1)-c1ccccc1)C(=O)C=C1CCN(C1)C#N
Show InChI InChI=1S/C18H18N4O2/c1-21(18(23)9-14-7-8-22(11-14)13-19)12-16-10-17(24-20-16)15-5-3-2-4-6-15/h2-6,9-10H,7-8,11-12H2,1H3/b14-9-
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498851
PNG
(2-(1-Cyanopyrrolidin-3- ylidene)-N-methyl-N-((3- p...)
Show SMILES CN(Cc1cc(no1)-c1ccccc1)C(=O)C=C1CCN(C1)C#N
Show InChI InChI=1S/C18H18N4O2/c1-21(18(23)9-14-7-8-22(11-14)13-19)12-16-10-17(20-24-16)15-5-3-2-4-6-15/h2-6,9-10H,7-8,11-12H2,1H3/b14-9-
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498853
PNG
(2-(1-Cyanopyrrolidin-3- ylidene)-N-methyl-((2- phe...)
Show SMILES CNC(=O)C(Cc1csc(n1)-c1ccccc1)=C1CCN(C1)C#N
Show InChI InChI=1S/C18H18N4OS/c1-20-17(23)16(14-7-8-22(10-14)12-19)9-15-11-24-18(21-15)13-5-3-2-4-6-13/h2-6,11H,7-10H2,1H3,(H,20,23)/b16-14-
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498858
PNG
((S)—N-(3-(4-Chlorophenyl)isoxazol-5-yl)-2-(1-...)
Show SMILES Clc1ccc(cc1)-c1cc(NC(=O)C[C@@H]2CCN(C2)C#N)on1
Show InChI InChI=1S/C16H15ClN4O2/c17-13-3-1-12(2-4-13)14-8-16(23-20-14)19-15(22)7-11-5-6-21(9-11)10-18/h1-4,8,11H,5-7,9H2,(H,19,22)/t11-/m0/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498861
PNG
((S)—N-(3-(3-Methoxyphenyl)isoxazol-5-yl)-2-(1...)
Show SMILES COc1cccc(c1)-c1cc(NC(=O)C[C@@H]2CCN(C2)C#N)on1
Show InChI InChI=1S/C17H18N4O3/c1-23-14-4-2-3-13(8-14)15-9-17(24-20-15)19-16(22)7-12-5-6-21(10-12)11-18/h2-4,8-9,12H,5-7,10H2,1H3,(H,19,22)/t12-/m0/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498831
PNG
(2-(1-Cyanopyrrolidin-3-yl)-N-(5- phenylpyrrolidin-...)
Show SMILES O=C(CC1CCN(C1)C#N)NC1CCC(N1)c1ccccc1
Show InChI InChI=1S/C17H22N4O/c18-12-21-9-8-13(11-21)10-17(22)20-16-7-6-15(19-16)14-4-2-1-3-5-14/h1-5,13,15-16,19H,6-11H2,(H,20,22)
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498832
PNG
(N-(5-Chlorobenzo[d]oxazol-2- yl)-2-(1-cyanopyrroli...)
Show SMILES Clc1ccc2oc(NC(=O)CC3CCN(C3)C#N)nc2c1
Show InChI InChI=1S/C14H13ClN4O2/c15-10-1-2-12-11(6-10)17-14(21-12)18-13(20)5-9-3-4-19(7-9)8-16/h1-2,6,9H,3-5,7H2,(H,17,18,20)
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498836
PNG
(3-(2-Oxo-2-(3- phenoxyazetidin-1- yl)ethyl)pyrroli...)
Show SMILES O=C(CC1CCN(C1)C#N)N1CC(C1)Oc1ccccc1
Show InChI InChI=1S/C16H19N3O2/c17-12-18-7-6-13(9-18)8-16(20)19-10-15(11-19)21-14-4-2-1-3-5-14/h1-5,13,15H,6-11H2
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498844
PNG
(N-(4-Chloro-3- (trifluoromethyl)phenyl)-2-(1- cyan...)
Show SMILES FC(F)(F)c1cc(NC(=O)C=C2CCN(C2)C#N)ccc1Cl
Show InChI InChI=1S/C14H11ClF3N3O/c15-12-2-1-10(6-11(12)14(16,17)18)20-13(22)5-9-3-4-21(7-9)8-19/h1-2,5-6H,3-4,7H2,(H,20,22)/b9-5+
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498872
PNG
(US11014912, Example 48)
Show SMILES Clc1cccc(c1)-c1nnc(NC(=O)C[C@@H]2CCN(C2)C#N)o1
Show InChI InChI=1S/C15H14ClN5O2/c16-12-3-1-2-11(7-12)14-19-20-15(23-14)18-13(22)6-10-4-5-21(8-10)9-17/h1-3,7,10H,4-6,8H2,(H,18,20,22)/t10-/m0/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498887
PNG
(US11014912, Example 65)
Show SMILES CC(C)Oc1ccc(nc1)C1CN(C1)C(=O)C[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C18H24N4O2/c1-13(2)24-16-3-4-17(20-8-16)15-10-22(11-15)18(23)7-14-5-6-21(9-14)12-19/h3-4,8,13-15H,5-7,9-11H2,1-2H3/t14-/m0/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498837
PNG
(3-(2-(3-(3- Methoxyphenyl) azetidin-1-yl)-2- oxoet...)
Show SMILES COc1cccc(c1)C1CN(C1)C(=O)CC1CCN(C1)C#N
Show InChI InChI=1S/C17H21N3O2/c1-22-16-4-2-3-14(8-16)15-10-20(11-15)17(21)7-13-5-6-19(9-13)12-18/h2-4,8,13,15H,5-7,9-11H2,1H3
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498841
PNG
(US11014912, Example 17)
Show SMILES COc1ccc(cc1)C1CN(C1)C(=O)C=C1CCN(C1)C#N
Show InChI InChI=1S/C17H19N3O2/c1-22-16-4-2-14(3-5-16)15-10-20(11-15)17(21)8-13-6-7-19(9-13)12-18/h2-5,8,15H,6-7,9-11H2,1H3/b13-8+
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498871
PNG
(US11014912, Example 47)
Show SMILES O=C(CC1CCN(C1)C#N)NC1CN(C1)c1ccccn1
Show InChI InChI=1S/C15H19N5O/c16-11-19-6-4-12(8-19)7-15(21)18-13-9-20(10-13)14-3-1-2-5-17-14/h1-3,5,12-13H,4,6-10H2,(H,18,21)
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498873
PNG
(US11014912, Example 49)
Show SMILES O=C(CC1CCN(C1)C#N)Nc1nnc(o1)-c1cccc(c1)C#N
Show InChI InChI=1S/C16H14N6O2/c17-8-11-2-1-3-13(6-11)15-20-21-16(24-15)19-14(23)7-12-4-5-22(9-12)10-18/h1-3,6,12H,4-5,7,9H2,(H,19,21,23)
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498826
PNG
(N-(3-Chlorophenyl)-2-(1- cyanopyrrolidin-3-yl)acet...)
Show SMILES Clc1cccc(NC(=O)CC2CCN(C2)C#N)c1
Show InChI InChI=1S/C13H14ClN3O/c14-11-2-1-3-12(7-11)16-13(18)6-10-4-5-17(8-10)9-15/h1-3,7,10H,4-6,8H2,(H,16,18)
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498842
PNG
(3-(2-Oxo-2-(3-phenylazetidin-1-yl)ethylidene)pyrro...)
Show SMILES O=C(C=C1CCN(C1)C#N)N1CC(C1)c1ccccc1
Show InChI InChI=1S/C16H17N3O/c17-12-18-7-6-13(9-18)8-16(20)19-10-15(11-19)14-4-2-1-3-5-14/h1-5,8,15H,6-7,9-11H2/b13-8+
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498843
PNG
(N-(3-Chloro-4-methylphenyl)- 2-(1-cyanopyrrolidin-...)
Show SMILES Cc1ccc(NC(=O)C=C2CCN(C2)C#N)cc1Cl
Show InChI InChI=1S/C14H14ClN3O/c1-10-2-3-12(7-13(10)15)17-14(19)6-11-4-5-18(8-11)9-16/h2-3,6-7H,4-5,8H2,1H3,(H,17,19)/b11-6-
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498850
PNG
(2-(1-Cyanopyrrolidin-3- ylidene)-N-methyl-N-(3- (p...)
Show SMILES CN(Cc1cccc(c1)-c1ccncc1)C(=O)C=C1CCN(C1)C#N
Show InChI InChI=1S/C20H20N4O/c1-23(20(25)12-17-7-10-24(14-17)15-21)13-16-3-2-4-19(11-16)18-5-8-22-9-6-18/h2-6,8-9,11-12H,7,10,13-14H2,1H3/b17-12-
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498882
PNG
(US11014912, Example 58)
Show SMILES Oc1ccc(cc1)C1CN(C1)C(=O)CC1CCN(C1)C#N
Show InChI InChI=1S/C16H19N3O2/c17-11-18-6-5-12(8-18)7-16(21)19-9-14(10-19)13-1-3-15(20)4-2-13/h1-4,12,14,20H,5-10H2
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498829
PNG
(N-(6-Chlorobenzo[d]thiazol-2- yl)-2-(1-cyanopyrrol...)
Show SMILES Clc1ccc2nc(NC(=O)CC3CCN(C3)C#N)sc2c1
Show InChI InChI=1S/C14H13ClN4OS/c15-10-1-2-11-12(6-10)21-14(17-11)18-13(20)5-9-3-4-19(7-9)8-16/h1-2,6,9H,3-5,7H2,(H,17,18,20)
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498830
PNG
(2-(1-Cyanopyrrolidin-3-yl)-N-(3- phenylisoxazol-5-...)
Show SMILES O=C(CC1CCN(C1)C#N)Nc1cc(no1)-c1ccccc1
Show InChI InChI=1S/C16H16N4O2/c17-11-20-7-6-12(10-20)8-15(21)18-16-9-14(19-22-16)13-4-2-1-3-5-13/h1-5,9,12H,6-8,10H2,(H,18,21)
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498833
PNG
(2-(1-Cyanopyrrolidin-3-yl)-N- (3,4-dichlorophenyl)...)
Show SMILES Clc1ccc(NC(=O)CC2CCN(C2)C#N)cc1Cl
Show InChI InChI=1S/C13H13Cl2N3O/c14-11-2-1-10(6-12(11)15)17-13(19)5-9-3-4-18(7-9)8-16/h1-2,6,9H,3-5,7H2,(H,17,19)
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498848
PNG
(2-(1-Cyanopyrrolidin-3- ylidene)-N-methyl-N-(quino...)
Show SMILES CN(Cc1ccc2ncccc2c1)C(=O)C=C1CCN(C1)C#N
Show InChI InChI=1S/C18H18N4O/c1-21(18(23)10-15-6-8-22(12-15)13-19)11-14-4-5-17-16(9-14)3-2-7-20-17/h2-5,7,9-10H,6,8,11-12H2,1H3/b15-10-
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498891
PNG
(US11014912, Example 62)
Show SMILES CC([C@H]1CCN(C1)C#N)C(=O)N1CC(C1)c1ccc(cc1)C#N
Show InChI InChI=1S/C18H20N4O/c1-13(16-6-7-21(9-16)12-20)18(23)22-10-17(11-22)15-4-2-14(8-19)3-5-15/h2-5,13,16-17H,6-7,9-11H2,1H3/t13?,16-/m0/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498825
PNG
(US11014912, Example 1)
Show SMILES COc1ccc(cc1)C1CN(C1)C(=O)CC1CCN(C1)C#N
Show InChI InChI=1S/C17H21N3O2/c1-22-16-4-2-14(3-5-16)15-10-20(11-15)17(21)8-13-6-7-19(9-13)12-18/h2-5,13,15H,6-11H2,1H3
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498838
PNG
(2-(1- Cyanopyrrolidin-3- yl)-N-(3,4- dichloropheny...)
Show SMILES Fc1ccc(cc1F)C1CN(C1)C(=O)CC1CCN(C1)C#N
Show InChI InChI=1S/C16H17F2N3O/c17-14-2-1-12(6-15(14)18)13-8-21(9-13)16(22)5-11-3-4-20(7-11)10-19/h1-2,6,11,13H,3-5,7-9H2
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498869
PNG
(US11014912, Example 45)
Show SMILES FC(F)(F)c1ccnc(NC(=O)CC2CCN(C2)C#N)c1
Show InChI InChI=1S/C13H13F3N4O/c14-13(15,16)10-1-3-18-11(6-10)19-12(21)5-9-2-4-20(7-9)8-17/h1,3,6,9H,2,4-5,7H2,(H,18,19,21)
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498880
PNG
(US11014912, Example 56)
Show SMILES O=C(C[C@@H]1CCN(C1)C#N)N1CC(C1)c1cccc(c1)C#N
Show InChI InChI=1S/C17H18N4O/c18-8-13-2-1-3-15(6-13)16-10-21(11-16)17(22)7-14-4-5-20(9-14)12-19/h1-3,6,14,16H,4-5,7,9-11H2/t14-/m0/s1
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498834
PNG
(2-(1- Cyanopyrrolidin-3- yl)-N-(5- phenylthiazol-2...)
Show SMILES O=C(CC1CCN(C1)C#N)Nc1ncc(s1)-c1ccccc1
Show InChI InChI=1S/C16H16N4OS/c17-11-20-7-6-12(10-20)8-15(21)19-16-18-9-14(22-16)13-4-2-1-3-5-13/h1-5,9,12H,6-8,10H2,(H,18,19,21)
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498847
PNG
(2-(1-Cyanopyrrolidin-3- ylidene)-N-(quinolin-3- yl...)
Show SMILES O=C(Nc1cnc2ccccc2c1)C=C1CCN(C1)C#N
Show InChI InChI=1S/C16H14N4O/c17-11-20-6-5-12(10-20)7-16(21)19-14-8-13-3-1-2-4-15(13)18-9-14/h1-4,7-9H,5-6,10H2,(H,19,21)/b12-7-
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Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498852
PNG
(2-(1-Cyanopyrrolidin-3- ylidene)-N-methyl-N-(4- (p...)
Show SMILES CN(Cc1ccc(cc1)N1CCCC1)C(=O)C=C1CCN(C1)C#N
Show InChI InChI=1S/C19H24N4O/c1-21(19(24)12-17-8-11-22(14-17)15-20)13-16-4-6-18(7-5-16)23-9-2-3-10-23/h4-7,12H,2-3,8-11,13-14H2,1H3/b17-12-
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498854
PNG
(2-(1-Cyanopyrrolidin-3- ylidene)-N-methyl-N-((5- p...)
Show SMILES CN(Cc1cc(n[nH]1)-c1ccccc1)C(=O)C=C1CCN(C1)C#N
Show InChI InChI=1S/C18H19N5O/c1-22(18(24)9-14-7-8-23(11-14)13-19)12-16-10-17(21-20-16)15-5-3-2-4-6-15/h2-6,9-10H,7-8,11-12H2,1H3,(H,20,21)/b14-9-
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498892
PNG
(US11014912, Example 64)
Show SMILES O=C(C[C@@H]1CCN(C1)C#N)Nc1nnc(s1)-c1ccccc1
Show InChI InChI=1S/C15H15N5OS/c16-10-20-7-6-11(9-20)8-13(21)17-15-19-18-14(22-15)12-4-2-1-3-5-12/h1-5,11H,6-9H2,(H,17,19,21)/t11-/m0/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498845
PNG
(N-(Benzo[d]thiazol-6-yl)-2-(1- cyanopyrrolidin-3- ...)
Show SMILES O=C(Nc1ccc2ncsc2c1)C=C1CCN(C1)C#N
Show InChI InChI=1S/C14H12N4OS/c15-8-18-4-3-10(7-18)5-14(19)17-11-1-2-12-13(6-11)20-9-16-12/h1-2,5-6,9H,3-4,7H2,(H,17,19)/b10-5+
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498855
PNG
(2-(1-Cyanopyrrolidin-3- ylidene)-N-(2-fluoro-5- (t...)
Show SMILES Fc1ccc(cc1CNC(=O)C=C1CCN(C1)C#N)C(F)(F)F
Show InChI InChI=1S/C15H13F4N3O/c16-13-2-1-12(15(17,18)19)6-11(13)7-21-14(23)5-10-3-4-22(8-10)9-20/h1-2,5-6H,3-4,7-8H2,(H,21,23)/b10-5-
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498835
PNG
(2-(1- Cyanopyrrolidin-3- yl)-N- phenethylacetamide...)
Show SMILES O=C(CC1CCN(C1)C#N)NCCc1ccccc1
Show InChI InChI=1S/C15H19N3O/c16-12-18-9-7-14(11-18)10-15(19)17-8-6-13-4-2-1-3-5-13/h1-5,14H,6-11H2,(H,17,19)
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498839
PNG
(3-(2-(3-(2- Methylpyridin-4- yl)azetidin-1-yl)-2- ...)
Show SMILES Cc1cc(ccn1)C1CN(C1)C(=O)CC1CCN(C1)C#N
Show InChI InChI=1S/C16H20N4O/c1-12-6-14(2-4-18-12)15-9-20(10-15)16(21)7-13-3-5-19(8-13)11-17/h2,4,6,13,15H,3,5,7-10H2,1H3
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498885
PNG
(US11014912, Example 61)
Show SMILES CC([C@@H]1CCN(C1)C#N)C(=O)N1CC(C1)c1ccc(cc1)C#N
Show InChI InChI=1S/C18H20N4O/c1-13(16-6-7-21(9-16)12-20)18(23)22-10-17(11-22)15-4-2-14(8-19)3-5-15/h2-5,13,16-17H,6-7,9-11H2,1H3/t13?,16-/m1/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498868
PNG
(US11014912, Example 44)
Show SMILES O=C(CC1CCN(C1)C#N)Nc1cc2ccccn2n1
Show InChI InChI=1S/C14H15N5O/c15-10-18-6-4-11(9-18)7-14(20)16-13-8-12-3-1-2-5-19(12)17-13/h1-3,5,8,11H,4,6-7,9H2,(H,16,17,20)
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498828
PNG
(2-(1-Cyanopyrrolidin-3-yl)-N-(6- (trifluoromethyl)...)
Show SMILES FC(F)(F)c1ccc(NC(=O)CC2CCN(C2)C#N)cn1
Show InChI InChI=1S/C13H13F3N4O/c14-13(15,16)11-2-1-10(6-18-11)19-12(21)5-9-3-4-20(7-9)8-17/h1-2,6,9H,3-5,7H2,(H,19,21)
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498840
PNG
(2-(1-Cyanopyrrolidin-3-yl)-N-(6-(3,5-dimethylisoxa...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(NC(=O)CC3CCN(C3)C#N)cn2c1
Show InChI InChI=1S/C19H20N6O2/c1-12-19(13(2)27-23-12)15-3-4-17-21-16(10-25(17)9-15)22-18(26)7-14-5-6-24(8-14)11-20/h3-4,9-10,14H,5-8H2,1-2H3,(H,22,26)
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498886
PNG
(US11014912, Example 63)
Show SMILES O=C(C[C@H]1CCN(C1)C#N)Nc1nnc(s1)-c1ccccc1
Show InChI InChI=1S/C15H15N5OS/c16-10-20-7-6-11(9-20)8-13(21)17-15-19-18-14(22-15)12-4-2-1-3-5-12/h1-5,11H,6-9H2,(H,17,19,21)/t11-/m1/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498870
PNG
(US11014912, Example 46)
Show SMILES O=C(CC1CCN(C1)C#N)Nc1ccc(cn1)C#N
Show InChI InChI=1S/C13H13N5O/c14-6-11-1-2-12(16-7-11)17-13(19)5-10-3-4-18(8-10)9-15/h1-2,7,10H,3-5,8H2,(H,16,17,19)
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM498888
PNG
(US11014912, Example 66)
Show SMILES COCCOc1ccc(cc1)C1CN(C1)C(=O)C[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C19H25N3O3/c1-24-8-9-25-18-4-2-16(3-5-18)17-12-22(13-17)19(23)10-15-6-7-21(11-15)14-20/h2-5,15,17H,6-13H2,1H3/t15-/m0/s1
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US Patent


Assay Description
Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...


US Patent US11014912 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%