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Patent code US11014913

Compile Data Set for Download or QSAR

Found 855 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431323
PNG
(US10550105, Example 268 | US10870641, Example 268 ...)
Show SMILES FC(F)(F)c1c(cn[nH]c1=O)N1Cc2cccc(OC3CCCOC3)c2C1
PDB

UniProtKB/SwissProt

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US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431325
PNG
(US10550105, Example 270 | US10870641, Example 270 ...)
Show SMILES CN(CC1CCCO1)c1cccc2CN(Cc12)c1cn[nH]c(=O)c1C(F)(F)F
PDB

UniProtKB/SwissProt

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n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431329
PNG
(US10550105, Example 274 | US10870641, Example 274 ...)
Show SMILES COc1cc(F)cc2CN(Cc12)c1cn[nH]c(=O)c1C(F)(F)F
Show InChI InChI=1S/C14H11F4N3O2/c1-23-11-3-8(15)2-7-5-21(6-9(7)11)10-4-19-20-13(22)12(10)14(16,17)18/h2-4H,5-6H2,1H3,(H,20,22)
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431299
PNG
(US10550105, Example 244 | US10550105, Example 288 ...)
Show SMILES FC(F)(F)c1c(cn[nH]c1=O)N1Cc2ccc(OC3CCCNC3)cc2C1
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431384
PNG
(US10550105, Example 329 | US10870641, Example 329 ...)
Show SMILES FC(F)(F)c1c(cn[nH]c1=O)N1Cc2cccc(CNCc3ccncc3)c2C1
Show InChI InChI=1S/C20H18F3N5O/c21-20(22,23)18-17(10-26-27-19(18)29)28-11-15-3-1-2-14(16(15)12-28)9-25-8-13-4-6-24-7-5-13/h1-7,10,25H,8-9,11-12H2,(H,27,29)
PDB

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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431386
PNG
(US10550105, Example 331 | US10870641, Example 331 ...)
Show SMILES CN(C)CCOc1cc2CN(Cc2c(F)c1)c1cn[nH]c(=O)c1C(F)(F)F
Show InChI InChI=1S/C17H18F4N4O2/c1-24(2)3-4-27-11-5-10-8-25(9-12(10)13(18)6-11)14-7-22-23-16(26)15(14)17(19,20)21/h5-7H,3-4,8-9H2,1-2H3,(H,23,26)
PDB

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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431408
PNG
(US10550105, Example 353 | US10870641, Example 353 ...)
Show SMILES FC(F)(F)c1c(cn[nH]c1=O)N1Cc2ccccc2[C@H]1COc1cncc(c1)C(=O)N1CCN(CC1)c1ccc(cn1)C#N
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431085
PNG
(US10550105, Example 357 | US10550105, Example 64B ...)
Show SMILES FC(F)(F)c1c(cn[nH]c1=O)N1Cc2ccccc2[C@H]1COc1ccnc(c1)C(=O)N1CCN(CC1)c1ccc(cn1)C#N
PDB

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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431434
PNG
(US10550105, Example 379 | US10870641, Example 379 ...)
Show SMILES FC(F)(F)c1c(cn[nH]c1=O)N1Cc2ccccc2C1COc1cncc(c1)C(=O)N1CCN(CC1)c1ncc(cn1)C#N
PDB

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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431436
PNG
(US10550105, Example 381 | US10870641, Example 381 ...)
Show SMILES FC(F)(F)c1c(cn[nH]c1=O)N1Cc2ccccc2C1COc1cc(ccn1)C(=O)N1CCN(CC1)c1ccc(cn1)C#N
PDB

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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431437
PNG
(US10550105, Example 382 | US10870641, Example 382 ...)
Show SMILES FC(F)(F)c1c(cn[nH]c1=O)N1Cc2ccccc2C1COc1cncc(n1)C(=O)N1CCN(CC1)c1ccc(cn1)C#N
PDB

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n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431457
PNG
(US10550105, Example 402 | US10870641, Example 402 ...)
Show SMILES FC(F)(F)c1c(cn[nH]c1=O)N1Cc2cccc(CCOc3ccc(cc3)C(=O)N3CCN(CC3)c3ccc(cn3)C#N)c2C1
Show InChI InChI=1S/C32H28F3N7O3/c33-32(34,35)29-27(18-38-39-30(29)43)42-19-24-3-1-2-22(26(24)20-42)10-15-45-25-7-5-23(6-8-25)31(44)41-13-11-40(12-14-41)28-9-4-21(16-36)17-37-28/h1-9,17-18H,10-15,19-20H2,(H,39,43)
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431467
PNG
(US10550105, Example 412 | US10870641, Example 412 ...)
Show SMILES FC(F)(F)c1c(cn[nH]c1=O)N1Cc2cccnc2C1COCCC(=O)N1CCN(CC1)c1ccc(cn1)C#N
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431490
PNG
(US10550105, Example 435 | US10870641, Example 435 ...)
Show SMILES FC(F)(F)c1c(cn[nH]c1=O)N1CCCC1COc1cccc(c1)C(=O)N1CCN(CC1)c1ccc(cn1)C#N
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431505
PNG
(US10550105, Example 450 | US10870641, Example 450 ...)
Show SMILES CC1CN(CCN1C(=O)c1cccc(OC[C@@H]2CCCN2c2cn[nH]c(=O)c2C(F)(F)F)c1)c1ccc(cn1)C#N
PDB

UniProtKB/SwissProt

GoogleScholar
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PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431524
PNG
(US10550105, Example 469 | US10870641, Example 469 ...)
Show SMILES FC(F)(F)c1c(cn[nH]c1=O)N1CCC(COc2cccc(c2)C(=O)N2CCN(CC2)c2ccc(cn2)C#N)C1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431535
PNG
(US10550105, Example 480 | US10870641, Example 480 ...)
Show SMILES Cc1c(cn[nH]c1=O)N1CCC[C@H]1COCCC(=O)N1CCN(CC1)c1ccc(cn1)C#N
PDB

UniProtKB/SwissProt

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PC sid
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US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431565
PNG
(6-[4-[3-(2-[Methyl[6-oxo-5-(trifluoromethyl)-1,6-d...)
Show SMILES CN(CCOCCC(=O)N1CCN(CC1)c1ccc(cn1)C#N)c1cn[nH]c(=O)c1C(F)(F)F
Show InChI InChI=1S/C21H24F3N7O3/c1-29(16-14-27-28-20(33)19(16)21(22,23)24)9-11-34-10-4-18(32)31-7-5-30(6-8-31)17-3-2-15(12-25)13-26-17/h2-3,13-14H,4-11H2,1H3,(H,28,33)
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431580
PNG
(US10550105, Example 521 | US10870641, Example 521 ...)
Show SMILES Clc1c(OCCOCCC(=O)N2CCN(CC2)c2ccc(cn2)C#N)cn[nH]c1=O
Show InChI InChI=1S/C19H21ClN6O4/c20-18-15(13-23-24-19(18)28)30-10-9-29-8-3-17(27)26-6-4-25(5-7-26)16-2-1-14(11-21)12-22-16/h1-2,12-13H,3-10H2,(H,24,28)
PDB

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PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM477283
PNG
(US10870641, Example 523 | US11014913, Example 523)
Show SMILES Clc1ccc(nc1)N1CCN(CC1)C(=O)CCOCCOc1cn[nH]c(=O)c1Cl
Show InChI InChI=1S/C18H21Cl2N5O4/c19-13-1-2-15(21-11-13)24-4-6-25(7-5-24)16(26)3-8-28-9-10-29-14-12-22-23-18(27)17(14)20/h1-2,11-12H,3-10H2,(H,23,27)
PDB

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PC sid
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US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431589
PNG
(US10550105, Example 528B | US10870641, Example 528...)
Show SMILES C[C@H](CC(=O)N1CCN(CC1)c1ccc(cn1)C#N)OCCNc1cn[nH]c(=O)c1C(F)(F)F
PDB

UniProtKB/SwissProt

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n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431615
PNG
(US10550105, Example 543C | US10870641, Example 543...)
Show SMILES C[C@H](COc1cn[nH]c(=O)c1C(F)(F)F)OCCC(=O)N1CCN(CC1)c1ncc(Cl)cn1
PDB

UniProtKB/SwissProt

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n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431622
PNG
(US10550105, Example 545B | US10550105, Example 545...)
Show SMILES FC(F)(F)c1ccc(nc1)N1CCN(CC1)C(=O)C[C@H]1CC[C@H](COc2cn[nH]c(=O)c2C(F)(F)F)O1
PDB

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n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431627
PNG
(US10550105, Example 546C | US10870641, Example 546...)
Show SMILES FC(F)(F)c1ccc(nc1)N1CCN(CC1)C(=O)C[C@H]1CC[C@@H](CNc2cn[nH]c(=O)c2C(F)(F)F)O1
PDB

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n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431635
PNG
(US10550105, Example 553 | US10870641, Example 553 ...)
Show SMILES FC(F)(F)c1cnc(nc1)N1CCN(CC1)C(=O)CCOCCOc1cn[nH]c(=O)c1C#N
Show InChI InChI=1S/C19H20F3N7O4/c20-19(21,22)13-10-24-18(25-11-13)29-4-2-28(3-5-29)16(30)1-6-32-7-8-33-15-12-26-27-17(31)14(15)9-23/h10-12H,1-8H2,(H,27,31)
PDB

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n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431639
PNG
(5-[[(2R)-1-[3-[4-(5-Chloropyrimidin-2-yl)piperazin...)
Show SMILES COC[C@H](COCCC(=O)N1CCN(CC1)c1ncc(Cl)cn1)Nc1cn[nH]c(=O)c1C(F)(F)F
PDB

UniProtKB/SwissProt

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UniChem
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n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431640
PNG
(5-[[(2S)-1-[3-[4-(5-Chloropyrimidin-2-yl)piperazin...)
Show SMILES COC[C@@H](COCCC(=O)N1CCN(CC1)c1ncc(Cl)cn1)Nc1cn[nH]c(=O)c1C(F)(F)F
PDB

UniProtKB/SwissProt

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UniChem
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n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431641
PNG
(5-[[(2S)-1-Methoxy-3-(3-oxo-3-[4-[5-(trifluorometh...)
Show SMILES COC[C@@H](COCCC(=O)N1CCN(CC1)c1ncc(cn1)C(F)(F)F)Nc1cn[nH]c(=O)c1C(F)(F)F
PDB

UniProtKB/SwissProt

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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431649
PNG
(US10550105, Example 564 | US10870641, Example 564 ...)
Show SMILES C[C@@H](COCCC(=O)N1CCN(CC1)c1ccc(cn1)C(F)(F)F)Nc1cn[nH]c(=O)c1C(F)(F)F
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US Patent
n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431662
PNG
(US10550105, Example 568A | US10550105, Example 568...)
Show SMILES FC(F)(F)c1cnc(nc1)N1CCN(CC1)C(=O)C[C@@H]1CC[C@@H](CNc2cn[nH]c(=O)c2C(F)(F)F)O1
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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431667
PNG
(US10550105, Example 570A | US11014913, Example 570...)
Show SMILES COC[C@@H](COCCC(=O)N1CCN(CC1)c1ncc(cn1)C(F)(F)F)Oc1cn[nH]c(=O)c1C(F)(F)F
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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM477376
PNG
(US10870641, Example 573A | US11014913, Example 573...)
Show SMILES OC[C@@H](COCCC(=O)N1CCN(CC1)c1ccc(cn1)C#N)Oc1cn[nH]c(=O)c1C(F)(F)F
PDB

UniProtKB/SwissProt

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n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431677
PNG
(US10550105, Example 573C | US10870641, Example 573...)
Show SMILES OC[C@@H](COc1cn[nH]c(=O)c1C(F)(F)F)OCCC(=O)N1CCN(CC1)c1ccc(cn1)C#N
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UniProtKB/SwissProt

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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431682
PNG
(US10550105, Example 574D | US10870641, Example 574...)
Show SMILES FC(F)(F)c1cnc(nc1)N1CCN(CC1)C(=O)C[C@@H]1CC[C@H](COc2cn[nH]c(=O)c2C(F)(F)F)O1
PDB

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n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM477392
PNG
(US10870641, Example 578A | US11014913, Example 578...)
Show SMILES C[C@@H](COCCC(=O)N1CCN(CC1)c1ncc(cn1)C(F)(F)F)Oc1cn[nH]c(=O)c1Cl
PDB

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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431697
PNG
(US10550105, Example 580D | US10870641, Example 580...)
Show SMILES FC(F)(F)c1c(OC[C@H]2CC[C@@H](CC(=O)N3CCN(CC3)c3ccc(cn3)C#N)O2)cn[nH]c1=O
PDB

UniProtKB/SwissProt

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n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431706
PNG
(US10550105, Example 583A | US10870641, Example 583...)
Show SMILES FC(F)(F)c1c(OC[C@@H]2CCC[C@@H](CC(=O)N3CCN(CC3)c3ccc(cn3)C#N)O2)cn[nH]c1=O
PDB

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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431714
PNG
(2-(4-(3-(2-(6-Oxo-5-(trifluoromethyl)-1,6-dihydrop...)
Show SMILES FC(F)(F)c1c(OCCOCCC(=O)N2CCN(CC2)c2ncc(cn2)C#N)cn[nH]c1=O
Show InChI InChI=1S/C19H20F3N7O4/c20-19(21,22)16-14(12-26-27-17(16)31)33-8-7-32-6-1-15(30)28-2-4-29(5-3-28)18-24-10-13(9-23)11-25-18/h10-12H,1-8H2,(H,27,31)
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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431732
PNG
(US10550105, Example 607 | US10550105, Example 698 ...)
Show SMILES COC(C)[C@@H](COCCC(=O)N1CCN(CC1)c1ncc(cn1)C(F)(F)F)Nc1cn[nH]c(=O)c1C(F)(F)F
PDB

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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431743
PNG
(US10550105, Example 614B | US10870641, Example 614...)
Show SMILES FC(F)(F)c1cnc(nc1)N1CCN(CC1)C(=O)CCOC[C@H](Nc1cn[nH]c(=O)c1C(F)(F)F)[C@H]1CCOC1
PDB

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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431750
PNG
((S)-5-((1-(3-Oxo-3-(4-(5-(trifluoromethyl)pyrimidi...)
Show SMILES C[C@@H](COCCC(=O)N1CCN(CC1)c1ncc(cn1)C(F)(F)F)Sc1cn[nH]c(=O)c1C(F)(F)F
PDB

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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431752
PNG
(US10550105, Example 619B | US10870641, Example 619...)
Show SMILES C[C@@H](COCCC(=O)N1CCN(C[C@H]1C)c1ncc(cn1)C(F)(F)F)Nc1cn[nH]c(=O)c1C(F)(F)F
PDB

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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431755
PNG
(US10550105, Example 621B | US10870641, Example 621...)
Show SMILES C[C@H](CSCCC(=O)N1CCN(CC1)c1ncc(cn1)C(F)(F)F)Oc1cn[nH]c(=O)c1C(F)(F)F
PDB

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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431758
PNG
((S)-5-((1-Methoxy-3-(2-[(4-(5-(trifluoromethyl)pyr...)
Show SMILES COC[C@@H](COCCS(=O)(=O)N1CCN(CC1)c1ncc(cn1)C(F)(F)F)Nc1cn[nH]c(=O)c1C(F)(F)F
PDB

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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431759
PNG
((S)-4-(Trifluoromethyl)-5-((1-(2-[(4-(5-(trifluoro...)
Show SMILES C[C@@H](COCCS(=O)(=O)N1CCN(CC1)c1ncc(s1)C(F)(F)F)Oc1cn[nH]c(=O)c1C(F)(F)F
PDB

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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431761
PNG
(US10550105, Example 627 | US10870641, Example 627 ...)
Show SMILES FC(F)(F)c1c(cn[nH]c1=O)N1Cc2ccccc2[C@H]1CNCCC(=O)N1CCN(CC1)c1ncc(Cl)cn1
PDB

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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431763
PNG
(US10550105, Example 629 | US10870641, Example 629 ...)
Show SMILES FC(F)(F)c1ccc(nc1)N1CCN(CC1)C(=O)CCNC[C@H]1N(Cc2ccccc12)c1cn[nH]c(=O)c1C(F)(F)F
PDB

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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431769
PNG
(US10550105, Example 635 | US10870641, Example 635 ...)
Show SMILES C[C@H](O)[C@@H](COCCC(=O)N1CCN(CC1)c1ncc(cn1)C(F)(F)F)Nc1cn[nH]c(=O)c1C(F)(F)F
PDB

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n/an/a<100n/an/an/an/an/an/a



Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431790
PNG
(US10550105, Example 656 | US10870641, Example 656 ...)
Show SMILES C[C@@H](COCCC(=O)N1CCN(CC1)c1ccc(CC#N)cn1)Oc1cn[nH]c(=O)c1C(F)(F)F
PDB

UniProtKB/SwissProt

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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
Protein mono-ADP-ribosyltransferase TIPARP


(Human)
BDBM431797
PNG
(US10550105, Example 663 | US10870641, Example 663 ...)
Show SMILES FC(F)(F)c1c(O[C@H](COCCC(=O)N2CCN(CC2)c2ccc(cn2)C#N)CN2CCOCC2)cn[nH]c1=O
PDB

UniProtKB/SwissProt

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Ribon Therapeutics, Inc.

US Patent


Assay Description
Displacement of Probe A, a biotinylated probe binding to the TIPARP active site, was measured using a time-resolved fluorescence energy transfer (TR-...


US Patent US11014913 (2021)

More data for this
Ligand-Target Pair
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