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Patent code US11014926

Compile Data Set for Download or QSAR
Found 35 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498956
PNG
(US11014926, Cpd. No. 27)
Show SMILES Clc1cc(cc2c1C(=O)NC21CCCC1)-n1ccc2cncnc12
Show InChI InChI=1S/C18H15ClN4O/c19-14-8-12(23-6-3-11-9-20-10-21-16(11)23)7-13-15(14)17(24)22-18(13)4-1-2-5-18/h3,6-10H,1-2,4-5H2,(H,22,24)
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n/an/a<10n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498957
PNG
(US11014926, Cpd. No. 28)
Show SMILES Nc1ncnc2n(ccc12)-c1cc2c(C(=O)NC22CCCCC2)c(Cl)c1
Show InChI InChI=1S/C19H18ClN5O/c20-14-9-11(25-7-4-12-16(21)22-10-23-17(12)25)8-13-15(14)18(26)24-19(13)5-2-1-3-6-19/h4,7-10H,1-3,5-6H2,(H,24,26)(H2,21,22,23)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM498947
PNG
(US11014926, Cpd. No. 18)
Show SMILES CC1(C)NC(=O)c2c1cc(cc2Cl)-n1ccc2cncnc12
Show InChI InChI=1S/C16H13ClN4O/c1-16(2)11-5-10(6-12(17)13(11)15(22)20-16)21-4-3-9-7-18-8-19-14(9)21/h3-8H,1-2H3,(H,20,22)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM498946
PNG
(US11014926, Cpd. No. 17)
Show SMILES CC1NC(=O)c2c1cc(cc2Cl)-n1ccc2cncnc12
Show InChI InChI=1S/C15H11ClN4O/c1-8-11-4-10(5-12(16)13(11)15(21)19-8)20-3-2-9-6-17-7-18-14(9)20/h2-8H,1H3,(H,19,21)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498947
PNG
(US11014926, Cpd. No. 18)
Show SMILES CC1(C)NC(=O)c2c1cc(cc2Cl)-n1ccc2cncnc12
Show InChI InChI=1S/C16H13ClN4O/c1-16(2)11-5-10(6-12(17)13(11)15(22)20-16)21-4-3-9-7-18-8-19-14(9)21/h3-8H,1-2H3,(H,20,22)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498959
PNG
(US11014926, Cpd. No. 30)
Show SMILES Nc1ncnc2n(ccc12)-c1cc2c(C(=O)NC22CCCC2)c(Cl)c1
Show InChI InChI=1S/C18H16ClN5O/c19-13-8-10(24-6-3-11-15(20)21-9-22-16(11)24)7-12-14(13)17(25)23-18(12)4-1-2-5-18/h3,6-9H,1-2,4-5H2,(H,23,25)(H2,20,21,22)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498946
PNG
(US11014926, Cpd. No. 17)
Show SMILES CC1NC(=O)c2c1cc(cc2Cl)-n1ccc2cncnc12
Show InChI InChI=1S/C15H11ClN4O/c1-8-11-4-10(5-12(16)13(11)15(21)19-8)20-3-2-9-6-17-7-18-14(9)20/h2-8H,1H3,(H,19,21)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM498937
PNG
(US11014926, Cpd. No. 8)
Show SMILES Cn1cc(cn1)-c1cn(-c2ccc3C(=O)NCc3c2)c2ncncc12
Show InChI InChI=1S/C18H14N6O/c1-23-8-12(6-22-23)16-9-24(17-15(16)7-19-10-21-17)13-2-3-14-11(4-13)5-20-18(14)25/h2-4,6-10H,5H2,1H3,(H,20,25)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498951
PNG
(US11014926, Cpd. No. 22)
Show SMILES CC1NC(=O)c2c1cc(cc2C)-n1ccc2cncnc12
Show InChI InChI=1S/C16H14N4O/c1-9-5-12(6-13-10(2)19-16(21)14(9)13)20-4-3-11-7-17-8-18-15(11)20/h3-8,10H,1-2H3,(H,19,21)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498958
PNG
(US11014926, Cpd. No. 29)
Show SMILES Clc1cc(cc2c1C(=O)NC21CCCCC1)-n1ccc2cncnc12
Show InChI InChI=1S/C19H17ClN4O/c20-15-9-13(24-7-4-12-10-21-11-22-17(12)24)8-14-16(15)18(25)23-19(14)5-2-1-3-6-19/h4,7-11H,1-3,5-6H2,(H,23,25)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498937
PNG
(US11014926, Cpd. No. 8)
Show SMILES Cn1cc(cn1)-c1cn(-c2ccc3C(=O)NCc3c2)c2ncncc12
Show InChI InChI=1S/C18H14N6O/c1-23-8-12(6-22-23)16-9-24(17-15(16)7-19-10-21-17)13-2-3-14-11(4-13)5-20-18(14)25/h2-4,6-10H,5H2,1H3,(H,20,25)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM498951
PNG
(US11014926, Cpd. No. 22)
Show SMILES CC1NC(=O)c2c1cc(cc2C)-n1ccc2cncnc12
Show InChI InChI=1S/C16H14N4O/c1-9-5-12(6-13-10(2)19-16(21)14(9)13)20-4-3-11-7-17-8-18-15(11)20/h3-8,10H,1-2H3,(H,19,21)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498942
PNG
(US11014926, Cpd. No. 13)
Show SMILES C1SCc2cc(ccc12)-n1ccc2cncnc12
Show InChI InChI=1S/C14H11N3S/c1-2-13(5-12-8-18-7-11(1)12)17-4-3-10-6-15-9-16-14(10)17/h1-6,9H,7-8H2
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498948
PNG
(US11014926, Cpd. No. 19)
Show SMILES O=C1NCc2cc(ccc12)-n1cc(-c2ccncc2)c2cncnc12
Show InChI InChI=1S/C19H13N5O/c25-19-15-2-1-14(7-13(15)8-22-19)24-10-17(12-3-5-20-6-4-12)16-9-21-11-23-18(16)24/h1-7,9-11H,8H2,(H,22,25)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498949
PNG
(US11014926, Cpd. No. 20)
Show SMILES COC(=O)NCC1NC(=O)c2ccc(cc12)-n1ccc2cncnc12
Show InChI InChI=1S/C17H15N5O3/c1-25-17(24)19-8-14-13-6-11(2-3-12(13)16(23)21-14)22-5-4-10-7-18-9-20-15(10)22/h2-7,9,14H,8H2,1H3,(H,19,24)(H,21,23)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498950
PNG
(US11014926, Cpd. No. 21)
Show SMILES NCC1NC(=O)c2ccc(cc12)-n1ccc2cncnc12
Show InChI InChI=1S/C15H13N5O/c16-6-13-12-5-10(1-2-11(12)15(21)19-13)20-4-3-9-7-17-8-18-14(9)20/h1-5,7-8,13H,6,16H2,(H,19,21)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498931
PNG
(US11014926, Cpd. No. 3)
Show SMILES CC1NC(=O)c2ccc(cc12)N1CCc2cncnc12
Show InChI InChI=1S/C15H14N4O/c1-9-13-6-11(2-3-12(13)15(20)18-9)19-5-4-10-7-16-8-17-14(10)19/h2-3,6-9H,4-5H2,1H3,(H,18,20)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498932
PNG
(US11014926, Cpd. No. 4)
Show SMILES O=C1NCc2cc(ccc12)-n1ncc2cnccc12
Show InChI InChI=1S/C14H10N4O/c19-14-12-2-1-11(5-9(12)7-16-14)18-13-3-4-15-6-10(13)8-17-18/h1-6,8H,7H2,(H,16,19)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498952
PNG
(US11014926, Cpd. No. 23)
Show SMILES Fc1cc(cc2CNC(=O)c12)-n1ccc2cncnc12
Show InChI InChI=1S/C14H9FN4O/c15-11-4-10(3-9-6-17-14(20)12(9)11)19-2-1-8-5-16-7-18-13(8)19/h1-5,7H,6H2,(H,17,20)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498955
PNG
(US11014926, Cpd. No. 26)
Show SMILES O=C1NCc2cc(ccc12)-n1cc(-c2ccccc2C#N)c2cncnc12
Show InChI InChI=1S/C21H13N5O/c22-8-13-3-1-2-4-16(13)19-11-26(20-18(19)10-23-12-25-20)15-5-6-17-14(7-15)9-24-21(17)27/h1-7,10-12H,9H2,(H,24,27)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498930
PNG
(US11014926, Cpd. No. 2)
Show SMILES CC1NC(=O)c2ccc(cc12)-n1ccc2cncnc12
Show InChI InChI=1S/C15H12N4O/c1-9-13-6-11(2-3-12(13)15(20)18-9)19-5-4-10-7-16-8-17-14(10)19/h2-9H,1H3,(H,18,20)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498933
PNG
(US11014926, Cpd. No. 5)
Show SMILES O=C1NCc2nc(ccc12)-n1ccc2cnccc12
Show InChI InChI=1S/C14H10N4O/c19-14-10-1-2-13(17-11(10)8-16-14)18-6-4-9-7-15-5-3-12(9)18/h1-7H,8H2,(H,16,19)
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eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498941
PNG
(US11014926, Cpd. No. 12)
Show SMILES Nc1ncnc2n(ccc12)-c1ccc2C(=O)NCc2c1
Show InChI InChI=1S/C14H11N5O/c15-12-11-3-4-19(13(11)18-7-17-12)9-1-2-10-8(5-9)6-16-14(10)20/h1-5,7H,6H2,(H,16,20)(H2,15,17,18)
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n/an/a 5.05E+3n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498954
PNG
(US11014926, Cpd. No. 25)
Show SMILES O=C1NCc2cc(ccc12)-n1cc(-c2cscn2)c2cncnc12
Show InChI InChI=1S/C17H11N5OS/c23-17-12-2-1-11(3-10(12)4-19-17)22-6-14(15-7-24-9-21-15)13-5-18-8-20-16(13)22/h1-3,5-9H,4H2,(H,19,23)
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n/an/a 5.05E+3n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498936
PNG
(US11014926, Cpd. No. 7)
Show SMILES Cc1ncnc2n(ccc12)-c1ccc2C(=O)NCc2c1
Show InChI InChI=1S/C15H12N4O/c1-9-12-4-5-19(14(12)18-8-17-9)11-2-3-13-10(6-11)7-16-15(13)20/h2-6,8H,7H2,1H3,(H,16,20)
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n/an/a 5.05E+3n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM498929
PNG
(US11014926, Cpd. No. 1)
Show SMILES O=C1NCc2cc(ccc12)-n1ccc2cncnc12
Show InChI InChI=1S/C14H10N4O/c19-14-12-2-1-11(5-10(12)7-16-14)18-4-3-9-6-15-8-17-13(9)18/h1-6,8H,7H2,(H,16,19)
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n/an/a 5.05E+3n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498943
PNG
(US11014926, Cpd. No. 14)
Show SMILES O=C1NCc2nc(ncc12)-n1ccc2cnccc12
Show InChI InChI=1S/C13H9N5O/c19-12-9-6-16-13(17-10(9)7-15-12)18-4-2-8-5-14-3-1-11(8)18/h1-6H,7H2,(H,15,19)
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n/an/a 5.05E+3n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498935
PNG
(US11014926, Cpd. No. 6)
Show SMILES c1cc2cncnc2n1-c1ccc2cnccc2c1
Show InChI InChI=1S/C15H10N4/c1-2-14(7-11-3-5-16-8-12(1)11)19-6-4-13-9-17-10-18-15(13)19/h1-10H
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n/an/a 5.05E+3n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498953
PNG
(US11014926, Cpd. No. 24)
Show SMILES Clc1ccccc1-c1cn(-c2ccc3C(=O)NCc3c2)c2ncncc12
Show InChI InChI=1S/C20H13ClN4O/c21-18-4-2-1-3-15(18)17-10-25(19-16(17)9-22-11-24-19)13-5-6-14-12(7-13)8-23-20(14)26/h1-7,9-11H,8H2,(H,23,26)
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n/an/a 5.05E+3n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498929
PNG
(US11014926, Cpd. No. 1)
Show SMILES O=C1NCc2cc(ccc12)-n1ccc2cncnc12
Show InChI InChI=1S/C14H10N4O/c19-14-12-2-1-11(5-10(12)7-16-14)18-4-3-9-6-15-8-17-13(9)18/h1-6,8H,7H2,(H,16,19)
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n/an/a 5.05E+3n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498940
PNG
(US11014926, Cpd. No. 11)
Show SMILES O=C1NCc2cc(ncc12)-n1ccc2cnccc12
Show InChI InChI=1S/C14H10N4O/c19-14-11-8-16-13(5-10(11)7-17-14)18-4-2-9-6-15-3-1-12(9)18/h1-6,8H,7H2,(H,17,19)
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n/an/a 5.05E+3n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498945
PNG
(US11014926, Cpd. No. 16)
Show SMILES O=C1NCc2cc(ccc12)-n1cnc2cncnc12
Show InChI InChI=1S/C13H9N5O/c19-13-10-2-1-9(3-8(10)4-15-13)18-7-17-11-5-14-6-16-12(11)18/h1-3,5-7H,4H2,(H,15,19)
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n/an/a 5.05E+3n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498944
PNG
(US11014926, Cpd. No. 15)
Show SMILES O=C1Cc2cc(ccc2N1)-n1ccc2cncnc12
Show InChI InChI=1S/C14H10N4O/c19-13-6-10-5-11(1-2-12(10)17-13)18-4-3-9-7-15-8-16-14(9)18/h1-5,7-8H,6H2,(H,17,19)
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n/an/a>5.70E+4n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498939
PNG
(US11014926, Cpd. No. 10)
Show SMILES O=C1NCc2cc(ccc12)-c1nccc2C(=O)NCc12
Show InChI InChI=1S/C15H11N3O2/c19-14-10-2-1-8(5-9(10)6-17-14)13-12-7-18-15(20)11(12)3-4-16-13/h1-5H,6-7H2,(H,17,19)(H,18,20)
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n/an/a>5.70E+4n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM498938
PNG
(US11014926, Cpd. No. 9)
Show SMILES CC1NC(=O)c2ccc(cc12)N1CCCc2cncnc12
Show InChI InChI=1S/C16H16N4O/c1-10-14-7-12(4-5-13(14)16(21)19-10)20-6-2-3-11-8-17-9-18-15(11)20/h4-5,7-10H,2-3,6H2,1H3,(H,19,21)
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n/an/a>5.70E+4n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
Compounds are screened for MNK inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...


US Patent US11014926 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%