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Patent code US11014929

Compile Data Set for Download or QSAR
Found 126 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498960
PNG
(US11014929, Example 1)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cnc(nc12)-c1ccccc1F
Show InChI InChI=1S/C22H21FN6/c1-28-10-12-29(13-11-28)16-8-6-15(7-9-16)20-21-19(26-27-20)14-24-22(25-21)17-4-2-3-5-18(17)23/h2-9,14H,10-13H2,1H3,(H,26,27)
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<50n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499036
PNG
(US11014929, Example 74)
Show SMILES CNCc1cc(F)c(c(F)c1)-c1ncc2[nH]nc(-c3ccc(nc3)N3CCN(CC3)S(C)(=O)=O)c2n1
Show InChI InChI=1S/C23H24F2N8O2S/c1-26-11-14-9-16(24)20(17(25)10-14)23-28-13-18-22(29-23)21(31-30-18)15-3-4-19(27-12-15)32-5-7-33(8-6-32)36(2,34)35/h3-4,9-10,12-13,26H,5-8,11H2,1-2H3,(H,30,31)
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<50n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499038
PNG
(US11014929, Example 76)
Show SMILES CNCc1cc(F)c(c(F)c1)-c1ncc2[nH]nc(-c3ccc(nc3)N3CCCCC3)c2n1
Show InChI InChI=1S/C23H23F2N7/c1-26-11-14-9-16(24)20(17(25)10-14)23-28-13-18-22(29-23)21(31-30-18)15-5-6-19(27-12-15)32-7-3-2-4-8-32/h5-6,9-10,12-13,26H,2-4,7-8,11H2,1H3,(H,30,31)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499039
PNG
(US11014929, Example 77)
Show SMILES CNCc1cc(F)c(-c2ncc3[nH]nc(-c4ccc(nc4)N4CCN(CC4)C(C)=O)c3n2)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H24F4N8O/c1-14(38)36-5-7-37(8-6-36)20-4-3-16(12-31-20)22-23-19(34-35-22)13-32-24(33-23)21-17(25(27,28)29)9-15(11-30-2)10-18(21)26/h3-4,9-10,12-13,30H,5-8,11H2,1-2H3,(H,34,35)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499050
PNG
(US11014929, Example 88)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3cc(C)n[nH]3)c2n1
Show InChI InChI=1S/C16H13FN6O/c1-8-6-10(21-20-8)15-14-11(22-23-15)7-18-16(19-14)13-9(17)4-3-5-12(13)24-2/h3-7H,1-2H3,(H,20,21)(H,22,23)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499060
PNG
(US11014929, Example 98)
Show SMILES Fc1cc2CCNCc2c(F)c1-c1ncc2[nH]nc(-c3ccc(nc3)N3CCOCC3)c2n1
Show InChI InChI=1S/C23H21F2N7O/c24-16-9-13-3-4-26-11-15(13)20(25)19(16)23-28-12-17-22(29-23)21(31-30-17)14-1-2-18(27-10-14)32-5-7-33-8-6-32/h1-2,9-10,12,26H,3-8,11H2,(H,30,31)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499062
PNG
(US11014929, Example 100)
Show SMILES COc1ccc(c2CCNCc12)-c1ncc2[nH]nc(-c3ccc(cc3)N3CCN(C)CC3)c2n1
Show InChI InChI=1S/C26H29N7O/c1-32-11-13-33(14-12-32)18-5-3-17(4-6-18)24-25-22(30-31-24)16-28-26(29-25)20-7-8-23(34-2)21-15-27-10-9-19(20)21/h3-8,16,27H,9-15H2,1-2H3,(H,30,31)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499070
PNG
(US11014929, Example 108)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cnc(nc12)-c1c(F)cc2CCNCc2c1C
Show InChI InChI=1S/C27H28FN7O/c1-16-21-14-29-8-7-19(21)13-22(28)24(16)27-30-15-23-26(31-27)25(33-32-23)18-3-5-20(6-4-18)35-11-9-34(10-12-35)17(2)36/h3-6,13,15,29H,7-12,14H2,1-2H3,(H,32,33)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499088
PNG
(US11014929, Example 126)
Show SMILES CNCc1cc(F)c(-c2ncc3[nH]nc(-c4ccc(nc4)N4CCO[C@@H](COC)C4)c3n2)c(c1)C(F)(F)F
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498966
PNG
(US11014929, Example 6)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cnc(nc12)-c1cncc(C)c1
Show InChI InChI=1S/C22H23N7/c1-15-11-17(13-23-12-15)22-24-14-19-21(25-22)20(27-26-19)16-3-5-18(6-4-16)29-9-7-28(2)8-10-29/h3-6,11-14H,7-10H2,1-2H3,(H,26,27)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498968
PNG
(US11014929, Example 8)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cnc(nc12)-c1cncc(c1)C(=O)N1CCOCC1
Show InChI InChI=1S/C26H28N8O2/c1-32-6-8-33(9-7-32)21-4-2-18(3-5-21)23-24-22(30-31-23)17-28-25(29-24)19-14-20(16-27-15-19)26(35)34-10-12-36-13-11-34/h2-5,14-17H,6-13H2,1H3,(H,30,31)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498970
PNG
(US11014929, Example 10)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cnc(nc12)-c1cccc2CNCCc12
Show InChI InChI=1S/C25H27N7/c1-31-11-13-32(14-12-31)19-7-5-17(6-8-19)23-24-22(29-30-23)16-27-25(28-24)21-4-2-3-18-15-26-10-9-20(18)21/h2-8,16,26H,9-15H2,1H3,(H,29,30)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498975
PNG
(US11014929, Example 15)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3ccncc3)c2n1
Show InChI InChI=1S/C17H12FN5O/c1-24-13-4-2-3-11(18)14(13)17-20-9-12-16(21-17)15(23-22-12)10-5-7-19-8-6-10/h2-9H,1H3,(H,22,23)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498985
PNG
(US11014929, Example 25)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3cccc(CN4CCN(C)CC4)c3)c2n1
Show InChI InChI=1S/C24H25FN6O/c1-30-9-11-31(12-10-30)15-16-5-3-6-17(13-16)22-23-19(28-29-22)14-26-24(27-23)21-18(25)7-4-8-20(21)32-2/h3-8,13-14H,9-12,15H2,1-2H3,(H,28,29)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498997
PNG
(US11014929, Example 37)
Show SMILES CCN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cnc(nc12)-c1c(F)cccc1OC
Show InChI InChI=1S/C24H25FN6O/c1-3-30-11-13-31(14-12-30)17-9-7-16(8-10-17)22-23-19(28-29-22)15-26-24(27-23)21-18(25)5-4-6-20(21)32-2/h4-10,15H,3,11-14H2,1-2H3,(H,28,29)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499015
PNG
(US11014929, Example 53)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3ccc(nc3)N3CCOCC3)c2n1
Show InChI InChI=1S/C21H19FN6O2/c1-29-16-4-2-3-14(22)18(16)21-24-12-15-20(25-21)19(27-26-15)13-5-6-17(23-11-13)28-7-9-30-10-8-28/h2-6,11-12H,7-10H2,1H3,(H,26,27)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499028
PNG
(US11014929, Example 66)
Show SMILES CNCc1cc(F)c(c(F)c1)-c1ncc2[nH]nc(-c3ccc(cc3)C3CCOCC3)c2n1
Show InChI InChI=1S/C24H23F2N5O/c1-27-12-14-10-18(25)21(19(26)11-14)24-28-13-20-23(29-24)22(31-30-20)17-4-2-15(3-5-17)16-6-8-32-9-7-16/h2-5,10-11,13,16,27H,6-9,12H2,1H3,(H,30,31)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499029
PNG
(US11014929, Example 67)
Show SMILES CCN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cnc(nc12)-c1c(F)cc(CNC)cc1F
Show InChI InChI=1S/C25H27F2N7/c1-3-33-8-10-34(11-9-33)18-6-4-17(5-7-18)23-24-21(31-32-23)15-29-25(30-24)22-19(26)12-16(14-28-2)13-20(22)27/h4-7,12-13,15,28H,3,8-11,14H2,1-2H3,(H,31,32)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499041
PNG
(US11014929, Example 79)
Show SMILES CNCc1cc(C)c(c(F)c1)-c1ncc2[nH]nc(-c3cnn(c3)-c3ccccc3C#N)c2n1
Show InChI InChI=1S/C24H19FN8/c1-14-7-15(10-27-2)8-18(25)21(14)24-28-12-19-23(30-24)22(32-31-19)17-11-29-33(13-17)20-6-4-3-5-16(20)9-26/h3-8,11-13,27H,10H2,1-2H3,(H,31,32)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499047
PNG
(US11014929, Example 85)
Show SMILES CNC(C)c1cc(F)c(c(F)c1)-c1ncc2[nH]nc(-c3cnn(C)c3)c2n1
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499055
PNG
(US11014929, Example 93)
Show SMILES CN(C)c1ncc(cn1)-c1n[nH]c2cnc(nc12)-c1c(F)cc2CCNCc2c1F
Show InChI InChI=1S/C20H18F2N8/c1-30(2)20-25-6-11(7-26-20)17-18-14(28-29-17)9-24-19(27-18)15-13(21)5-10-3-4-23-8-12(10)16(15)22/h5-7,9,23H,3-4,8H2,1-2H3,(H,28,29)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499058
PNG
(US11014929, Example 96)
Show SMILES Fc1cc2CCNCc2c(F)c1-c1ncc2[nH]nc(-c3ccc(cc3)S(=O)(=O)N3CCC3)c2n1
Show InChI InChI=1S/C23H20F2N6O2S/c24-17-10-14-6-7-26-11-16(14)20(25)19(17)23-27-12-18-22(28-23)21(30-29-18)13-2-4-15(5-3-13)34(32,33)31-8-1-9-31/h2-5,10,12,26H,1,6-9,11H2,(H,29,30)
PDB

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US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499066
PNG
(US11014929, Example 104)
Show SMILES CNCc1cc(C)c(cn1)-c1ncc2[nH]nc(-c3ccc(cc3)N3CCN(C)CC3)c2n1
Show InChI InChI=1S/C24H28N8/c1-16-12-18(13-25-2)26-14-20(16)24-27-15-21-23(28-24)22(30-29-21)17-4-6-19(7-5-17)32-10-8-31(3)9-11-32/h4-7,12,14-15,25H,8-11,13H2,1-3H3,(H,29,30)
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US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499081
PNG
(US11014929, Example 119)
Show SMILES COc1c2C(N)CCc2cc(F)c1-c1ncc2[nH]nc(-c3ccc(nc3)N3CCOCC3)c2n1
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US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498992
PNG
(US11014929, Example 32)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3ccc(cc3)C(=O)NC3CCCC3)c2n1
Show InChI InChI=1S/C24H22FN5O2/c1-32-19-8-4-7-17(25)20(19)23-26-13-18-22(28-23)21(30-29-18)14-9-11-15(12-10-14)24(31)27-16-5-2-3-6-16/h4,7-13,16H,2-3,5-6H2,1H3,(H,27,31)(H,29,30)
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US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498996
PNG
(US11014929, Example 36)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3ccc(F)cc3)c2n1
Show InChI InChI=1S/C18H12F2N4O/c1-25-14-4-2-3-12(20)15(14)18-21-9-13-17(22-18)16(24-23-13)10-5-7-11(19)8-6-10/h2-9H,1H3,(H,23,24)
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US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498998
PNG
(US11014929, Example 38)
Show SMILES CNC(=O)c1ccc(cc1)-c1n[nH]c2cnc(nc12)-c1c(F)cccc1OC
Show InChI InChI=1S/C20H16FN5O2/c1-22-20(27)12-8-6-11(7-9-12)17-18-14(25-26-17)10-23-19(24-18)16-13(21)4-3-5-15(16)28-2/h3-10H,1-2H3,(H,22,27)(H,25,26)
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US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499010
PNG
(US11014929, Example 48)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3cnn(c3)-c3ccccc3)c2n1
Show InChI InChI=1S/C21H15FN6O/c1-29-17-9-5-8-15(22)18(17)21-23-11-16-20(25-21)19(27-26-16)13-10-24-28(12-13)14-6-3-2-4-7-14/h2-12H,1H3,(H,26,27)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499011
PNG
(US11014929, Example 49)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(C3=C[C](=O)=[N](C)C=C3)c2n1
Show InChI InChI=1S/C18H14FN5O2/c1-24-7-6-10(8-14(24)25)16-17-12(22-23-16)9-20-18(21-17)15-11(19)4-3-5-13(15)26-2/h3-9H,1-2H3,(H,22,23)
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US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499013
PNG
(US11014929, Example 51)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3ccnc(c3)N3CCN(C)CC3)c2n1
Show InChI InChI=1S/C22H22FN7O/c1-29-8-10-30(11-9-29)18-12-14(6-7-24-18)20-21-16(27-28-20)13-25-22(26-21)19-15(23)4-3-5-17(19)31-2/h3-7,12-13H,8-11H2,1-2H3,(H,27,28)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499016
PNG
(US11014929, Example 54)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3ccc(nc3)N3CCN(CC3)C(C)=O)c2n1
Show InChI InChI=1S/C23H22FN7O2/c1-14(32)30-8-10-31(11-9-30)19-7-6-15(12-25-19)21-22-17(28-29-21)13-26-23(27-22)20-16(24)4-3-5-18(20)33-2/h3-7,12-13H,8-11H2,1-2H3,(H,28,29)
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US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499017
PNG
(US11014929, Example 55)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(\C=C\c3ccc(cc3)N3CCN(C)CC3)c2n1
Show InChI InChI=1S/C25H25FN6O/c1-31-12-14-32(15-13-31)18-9-6-17(7-10-18)8-11-20-24-21(30-29-20)16-27-25(28-24)23-19(26)4-3-5-22(23)33-2/h3-11,16H,12-15H2,1-2H3,(H,29,30)/b11-8+
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499018
PNG
(US11014929, Example 56)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cnc(nc12)-c1c(F)ccc2CNCCc12
Show InChI InChI=1S/C25H26FN7/c1-32-10-12-33(13-11-32)18-5-2-16(3-6-18)23-24-21(30-31-23)15-28-25(29-24)22-19-8-9-27-14-17(19)4-7-20(22)26/h2-7,15,27H,8-14H2,1H3,(H,30,31)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499023
PNG
(US11014929, Example 61)
Show SMILES CNCc1cc(F)c(c(F)c1)-c1ncc2[nH]nc(-c3ccc(nc3)C(=O)NC)c2n1
Show InChI InChI=1S/C20H17F2N7O/c1-23-7-10-5-12(21)16(13(22)6-10)19-26-9-15-18(27-19)17(29-28-15)11-3-4-14(25-8-11)20(30)24-2/h3-6,8-9,23H,7H2,1-2H3,(H,24,30)(H,28,29)
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US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499030
PNG
(US11014929, Example 68)
Show SMILES CNCc1cc(F)c(c(F)c1)-c1ncc2[nH]nc(-c3cnc(N4CCOCC4)c(c3)C#N)c2n1
Show InChI InChI=1S/C23H20F2N8O/c1-27-10-13-6-16(24)19(17(25)7-13)22-28-12-18-21(30-22)20(32-31-18)15-8-14(9-26)23(29-11-15)33-2-4-34-5-3-33/h6-8,11-12,27H,2-5,10H2,1H3,(H,31,32)
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US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499032
PNG
(US11014929, Example 70)
Show SMILES CNCc1cc(F)c(c(F)c1)-c1ncc2[nH]nc(-c3ccc(nc3)N3CCN(CC(C)(C)O)CC3)c2n1
Show InChI InChI=1S/C26H30F2N8O/c1-26(2,37)15-35-6-8-36(9-7-35)21-5-4-17(13-30-21)23-24-20(33-34-23)14-31-25(32-24)22-18(27)10-16(12-29-3)11-19(22)28/h4-5,10-11,13-14,29,37H,6-9,12,15H2,1-3H3,(H,33,34)
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US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499048
PNG
(US11014929, Example 86)
Show SMILES CNCc1cc(F)c(c(OC)c1)-c1ncc2[nH]nc(-c3cnn(C)c3)c2n1
Show InChI InChI=1S/C18H18FN7O/c1-20-6-10-4-12(19)15(14(5-10)27-3)18-21-8-13-17(23-18)16(25-24-13)11-7-22-26(2)9-11/h4-5,7-9,20H,6H2,1-3H3,(H,24,25)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499052
PNG
(US11014929, Example 90)
Show SMILES CN1CCN(CC1)c1cc(ccn1)-c1n[nH]c2cnc(nc12)-c1c(F)cc2CCNCc2c1F
Show InChI InChI=1S/C24H24F2N8/c1-33-6-8-34(9-7-33)19-11-15(3-5-28-19)22-23-18(31-32-22)13-29-24(30-23)20-17(25)10-14-2-4-27-12-16(14)21(20)26/h3,5,10-11,13,27H,2,4,6-9,12H2,1H3,(H,31,32)
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US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499061
PNG
(US11014929, Example 99)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cnc(nc12)-c1c(F)cc2CCNCc2c1F
Show InChI InChI=1S/C25H25F2N7/c1-33-8-10-34(11-9-33)17-4-2-15(3-5-17)23-24-20(31-32-23)14-29-25(30-24)21-19(26)12-16-6-7-28-13-18(16)22(21)27/h2-5,12,14,28H,6-11,13H2,1H3,(H,31,32)
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US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499072
PNG
(US11014929, Example 110)
Show SMILES CN1CCN(CC1)c1ccc(cn1)-c1n[nH]c2cnc(nc12)-c1c(F)cc2CCNCc2c1C
Show InChI InChI=1S/C25H27FN8/c1-15-18-13-27-6-5-16(18)11-19(26)22(15)25-29-14-20-24(30-25)23(32-31-20)17-3-4-21(28-12-17)34-9-7-33(2)8-10-34/h3-4,11-12,14,27H,5-10,13H2,1-2H3,(H,31,32)
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US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499077
PNG
(US11014929, Example 115)
Show SMILES CNC1CCc2cc(F)c(c(F)c2C1)-c1ncc2[nH]nc(-c3ccc(nc3)N3CCOCC3)c2n1
PDB

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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499080
PNG
(US11014929, Example 118)
Show SMILES NC1CCc2cc(F)c(c(F)c12)-c1ncc2[nH]nc(-c3ccc(nc3)N3CCOCC3)c2n1
PDB

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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499083
PNG
(US11014929, Example 121)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cnc(nc12)-c1c(F)ccc2C(N)CCCc12
PDB

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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499085
PNG
(US11014929, Example 123)
Show SMILES CNCc1cc(F)c(c(F)c1)-c1ncc2[nH]nc(-c3ccc(cc3)N3CCN(CCOC)CC3)c2n1
Show InChI InChI=1S/C26H29F2N7O/c1-29-15-17-13-20(27)23(21(28)14-17)26-30-16-22-25(31-26)24(33-32-22)18-3-5-19(6-4-18)35-9-7-34(8-10-35)11-12-36-2/h3-6,13-14,16,29H,7-12,15H2,1-2H3,(H,32,33)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498969
PNG
(US11014929, Example 9)
Show SMILES CNC(=O)c1cncc(c1)-c1ncc2[nH]nc(-c3ccc(cc3)N3CCN(C)CC3)c2n1
Show InChI InChI=1S/C23H24N8O/c1-24-23(32)17-11-16(12-25-13-17)22-26-14-19-21(27-22)20(29-28-19)15-3-5-18(6-4-15)31-9-7-30(2)8-10-31/h3-6,11-14H,7-10H2,1-2H3,(H,24,32)(H,28,29)
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US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498974
PNG
(US11014929, Example 14)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3cnn(C)c3)c2n1
Show InChI InChI=1S/C16H13FN6O/c1-23-8-9(6-19-23)14-15-11(21-22-14)7-18-16(20-15)13-10(17)4-3-5-12(13)24-2/h3-8H,1-2H3,(H,21,22)
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US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498979
PNG
(US11014929, Example 19)
Show SMILES COc1cccc(c1)-c1n[nH]c2cnc(nc12)-c1c(F)cccc1OC
Show InChI InChI=1S/C19H15FN4O2/c1-25-12-6-3-5-11(9-12)17-18-14(23-24-17)10-21-19(22-18)16-13(20)7-4-8-15(16)26-2/h3-10H,1-2H3,(H,23,24)
PDB

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US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498989
PNG
(US11014929, Example 29)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3cccc(c3)N3CCOCC3)c2n1
Show InChI InChI=1S/C22H20FN5O2/c1-29-18-7-3-6-16(23)19(18)22-24-13-17-21(25-22)20(27-26-17)14-4-2-5-15(12-14)28-8-10-30-11-9-28/h2-7,12-13H,8-11H2,1H3,(H,26,27)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499006
PNG
(US11014929, Example 44)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cnc(nc12)-c1cccc(F)c1F
Show InChI InChI=1S/C22H20F2N6/c1-29-9-11-30(12-10-29)15-7-5-14(6-8-15)20-21-18(27-28-20)13-25-22(26-21)16-3-2-4-17(23)19(16)24/h2-8,13H,9-12H2,1H3,(H,27,28)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499024
PNG
(US11014929, Example 62)
Show SMILES CNCc1cc(F)c(c(F)c1)-c1ncc2[nH]nc(-c3ccc(C(=O)NC)c(F)c3)c2n1
Show InChI InChI=1S/C21H17F3N6O/c1-25-8-10-5-14(23)17(15(24)6-10)20-27-9-16-19(28-20)18(30-29-16)11-3-4-12(13(22)7-11)21(31)26-2/h3-7,9,25H,8H2,1-2H3,(H,26,31)(H,29,30)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499027
PNG
(US11014929, Example 65)
Show SMILES CNCc1cc(F)c(c(F)c1)-c1ncc2[nH]nc(-c3ccc(cc3)C3CCNCC3)c2n1
Show InChI InChI=1S/C24H24F2N6/c1-27-12-14-10-18(25)21(19(26)11-14)24-29-13-20-23(30-24)22(32-31-20)17-4-2-15(3-5-17)16-6-8-28-9-7-16/h2-5,10-11,13,16,27-28H,6-9,12H2,1H3,(H,31,32)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499033
PNG
(US11014929, Example 71)
Show SMILES CNCc1cc(F)c(c(F)c1)-c1ncc2[nH]nc(-c3ccc(nc3)N3CCCC(C)(CO)C3)c2n1
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499037
PNG
(US11014929, Example 75)
Show SMILES CCN(C)C(=O)N1CCN(CC1)c1ccc(cn1)-c1n[nH]c2cnc(nc12)-c1c(F)cc(CNC)cc1F
Show InChI InChI=1S/C26H29F2N9O/c1-4-35(3)26(38)37-9-7-36(8-10-37)21-6-5-17(14-30-21)23-24-20(33-34-23)15-31-25(32-24)22-18(27)11-16(13-29-2)12-19(22)28/h5-6,11-12,14-15,29H,4,7-10,13H2,1-3H3,(H,33,34)
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A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499042
PNG
(US11014929, Example 80)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cnc(nc12)-c1c(C)cc(cc1F)C1CCCN1
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A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499043
PNG
(US11014929, Example 81)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cnc(nc12)-c1c(C)cc(cc1F)C1CCCCN1
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A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499045
PNG
(US11014929, Example 83)
Show SMILES CN(C)CC(=O)Nc1cc(F)c(c(F)c1)-c1ncc2[nH]nc(-c3cnn(C)c3)c2n1
Show InChI InChI=1S/C19H18F2N8O/c1-28(2)9-15(30)24-11-4-12(20)16(13(21)5-11)19-22-7-14-18(25-19)17(27-26-14)10-6-23-29(3)8-10/h4-8H,9H2,1-3H3,(H,24,30)(H,26,27)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499051
PNG
(US11014929, Example 89)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(OCc3ccccc3)c2n1
Show InChI InChI=1S/C19H15FN4O2/c1-25-15-9-5-8-13(20)16(15)18-21-10-14-17(22-18)19(24-23-14)26-11-12-6-3-2-4-7-12/h2-10H,11H2,1H3,(H,23,24)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499075
PNG
(US11014929, Example 113)
Show SMILES CNC1CCc2c1cc(F)c(c2F)-c1ncc2[nH]nc(-c3ccc(nc3)N3CCOCC3)c2n1
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499082
PNG
(US11014929, Example 120)
Show SMILES CNC1CCCc2c1ccc(F)c2-c1ncc2[nH]nc(-c3ccc(nc3)N3CCN(C)CC3)c2n1
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499086
PNG
(US11014929, Example 124)
Show SMILES CCN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cnc(nc12)-c1c(F)cc(CNC)cc1C(F)(F)F
Show InChI InChI=1S/C26H27F4N7/c1-3-36-8-10-37(11-9-36)18-6-4-17(5-7-18)23-24-21(34-35-23)15-32-25(33-24)22-19(26(28,29)30)12-16(14-31-2)13-20(22)27/h4-7,12-13,15,31H,3,8-11,14H2,1-2H3,(H,34,35)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498963
PNG
(US11014929, Example 4)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cnc(nc12)-c1c(F)cccc1Cl
Show InChI InChI=1S/C22H20ClFN6/c1-29-9-11-30(12-10-29)15-7-5-14(6-8-15)20-21-18(27-28-20)13-25-22(26-21)19-16(23)3-2-4-17(19)24/h2-8,13H,9-12H2,1H3,(H,27,28)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498977
PNG
(US11014929, Example 17)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3ccc(cc3)C#N)c2n1
Show InChI InChI=1S/C19H12FN5O/c1-26-15-4-2-3-13(20)16(15)19-22-10-14-18(23-19)17(25-24-14)12-7-5-11(9-21)6-8-12/h2-8,10H,1H3,(H,24,25)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498999
PNG
(US11014929, Example 39)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3ccc(cc3)C3CC3)c2n1
Show InChI InChI=1S/C21H17FN4O/c1-27-17-4-2-3-15(22)18(17)21-23-11-16-20(24-21)19(26-25-16)14-9-7-13(8-10-14)12-5-6-12/h2-4,7-12H,5-6H2,1H3,(H,25,26)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499019
PNG
(US11014929, Example 57)
Show SMILES Cc1cccc(F)c1-c1ncc2[nH]nc(-c3ccc(cc3)N3CCCC(O)C3)c2n1
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499046
PNG
(US11014929, Example 84)
Show SMILES CNCc1cc(F)c(c(F)c1)-c1ncc2[nH]nc(-c3cnn(C)c3)c2n1
Show InChI InChI=1S/C17H15F2N7/c1-20-5-9-3-11(18)14(12(19)4-9)17-21-7-13-16(23-17)15(25-24-13)10-6-22-26(2)8-10/h3-4,6-8,20H,5H2,1-2H3,(H,24,25)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499053
PNG
(US11014929, Example 91)
Show SMILES OCCNc1ncc(cn1)-c1n[nH]c2cnc(nc12)-c1c(F)cc2CCNCc2c1F
Show InChI InChI=1S/C20H18F2N8O/c21-13-5-10-1-2-23-8-12(10)16(22)15(13)19-25-9-14-18(28-19)17(30-29-14)11-6-26-20(27-7-11)24-3-4-31/h5-7,9,23,31H,1-4,8H2,(H,29,30)(H,24,26,27)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499056
PNG
(US11014929, Example 94)
Show SMILES CNc1ncc(cn1)-c1n[nH]c2cnc(nc12)-c1c(F)cc2CCNCc2c1F
Show InChI InChI=1S/C19H16F2N8/c1-22-19-25-5-10(6-26-19)16-17-13(28-29-16)8-24-18(27-17)14-12(20)4-9-2-3-23-7-11(9)15(14)21/h4-6,8,23H,2-3,7H2,1H3,(H,28,29)(H,22,25,26)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499069
PNG
(US11014929, Example 107)
Show SMILES CN1CCN(CC1)c1cc(ccn1)-c1n[nH]c2cnc(nc12)-c1c(F)cc2CCNCc2c1C
Show InChI InChI=1S/C25H27FN8/c1-15-18-13-27-5-3-16(18)11-19(26)22(15)25-29-14-20-24(30-25)23(32-31-20)17-4-6-28-21(12-17)34-9-7-33(2)8-10-34/h4,6,11-12,14,27H,3,5,7-10,13H2,1-2H3,(H,31,32)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499079
PNG
(US11014929, Example 117)
Show SMILES NC1CCCc2c(F)c(c(F)cc12)-c1ncc2[nH]nc(-c3ccc(nc3)N3CCOCC3)c2n1
PDB

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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498961
PNG
(US11014929, Example 2)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cnc(nc12)-c1ccccc1C
Show InChI InChI=1S/C23H24N6/c1-16-5-3-4-6-19(16)23-24-15-20-22(25-23)21(27-26-20)17-7-9-18(10-8-17)29-13-11-28(2)12-14-29/h3-10,15H,11-14H2,1-2H3,(H,26,27)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498972
PNG
(US11014929, Example 12)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3ccccc3)c2n1
Show InChI InChI=1S/C18H13FN4O/c1-24-14-9-5-8-12(19)15(14)18-20-10-13-17(21-18)16(23-22-13)11-6-3-2-4-7-11/h2-10H,1H3,(H,22,23)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498981
PNG
(US11014929, Example 21)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3ccsc3)c2n1
Show InChI InChI=1S/C16H11FN4OS/c1-22-12-4-2-3-10(17)13(12)16-18-7-11-15(19-16)14(21-20-11)9-5-6-23-8-9/h2-8H,1H3,(H,20,21)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498983
PNG
(US11014929, Example 23)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3ccc(CN4CCN(C)CC4)cc3)c2n1
Show InChI InChI=1S/C24H25FN6O/c1-30-10-12-31(13-11-30)15-16-6-8-17(9-7-16)22-23-19(28-29-22)14-26-24(27-23)21-18(25)4-3-5-20(21)32-2/h3-9,14H,10-13,15H2,1-2H3,(H,28,29)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498986
PNG
(US11014929, Example 26)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3ccc(cc3)N3CCOCC3)c2n1
Show InChI InChI=1S/C22H20FN5O2/c1-29-18-4-2-3-16(23)19(18)22-24-13-17-21(25-22)20(27-26-17)14-5-7-15(8-6-14)28-9-11-30-12-10-28/h2-8,13H,9-12H2,1H3,(H,26,27)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498987
PNG
(US11014929, Example 27)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3cccc(c3)N3CCNCC3)c2n1
Show InChI InChI=1S/C22H21FN6O/c1-30-18-7-3-6-16(23)19(18)22-25-13-17-21(26-22)20(28-27-17)14-4-2-5-15(12-14)29-10-8-24-9-11-29/h2-7,12-13,24H,8-11H2,1H3,(H,27,28)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498990
PNG
(US11014929, Example 30)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3cccc(c3)N(C)C)c2n1
Show InChI InChI=1S/C20H18FN5O/c1-26(2)13-7-4-6-12(10-13)18-19-15(24-25-18)11-22-20(23-19)17-14(21)8-5-9-16(17)27-3/h4-11H,1-3H3,(H,24,25)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498995
PNG
(US11014929, Example 35)
Show SMILES COc1ccc(cc1)-c1n[nH]c2cnc(nc12)-c1c(F)cccc1OC
Show InChI InChI=1S/C19H15FN4O2/c1-25-12-8-6-11(7-9-12)17-18-14(23-24-17)10-21-19(22-18)16-13(20)4-3-5-15(16)26-2/h3-10H,1-2H3,(H,23,24)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499003
PNG
(US11014929, Example 43)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3ccc(cc3)C3CCOCC3)c2n1
Show InChI InChI=1S/C23H21FN4O2/c1-29-19-4-2-3-17(24)20(19)23-25-13-18-22(26-23)21(28-27-18)16-7-5-14(6-8-16)15-9-11-30-12-10-15/h2-8,13,15H,9-12H2,1H3,(H,27,28)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499034
PNG
(US11014929, Example 72)
Show SMILES CNCc1cc(F)c(c(F)c1)-c1ncc2[nH]nc(-c3ccc(NC4CCN(CC4)S(C)(=O)=O)nc3)c2n1
Show InChI InChI=1S/C24H26F2N8O2S/c1-27-11-14-9-17(25)21(18(26)10-14)24-29-13-19-23(31-24)22(33-32-19)15-3-4-20(28-12-15)30-16-5-7-34(8-6-16)37(2,35)36/h3-4,9-10,12-13,16,27H,5-8,11H2,1-2H3,(H,28,30)(H,32,33)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499035
PNG
(US11014929, Example 73)
Show SMILES CNCc1cc(F)c(c(F)c1)-c1ncc2[nH]nc(-c3ccc(cc3)N3CCN(CCO)CC3)c2n1
Show InChI InChI=1S/C25H27F2N7O/c1-28-14-16-12-19(26)22(20(27)13-16)25-29-15-21-24(30-25)23(32-31-21)17-2-4-18(5-3-17)34-8-6-33(7-9-34)10-11-35/h2-5,12-13,15,28,35H,6-11,14H2,1H3,(H,31,32)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499059
PNG
(US11014929, Example 97)
Show SMILES FC(F)Oc1ccc(cn1)-c1n[nH]c2cnc(nc12)-c1c(F)cc2CCNCc2c1F
Show InChI InChI=1S/C20H14F4N6O/c21-12-5-9-3-4-25-7-11(9)16(22)15(12)19-27-8-13-18(28-19)17(30-29-13)10-1-2-14(26-6-10)31-20(23)24/h1-2,5-6,8,20,25H,3-4,7H2,(H,29,30)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499064
PNG
(US11014929, Example 102)
Show SMILES COc1ccncc1-c1ncc2[nH]nc(-c3ccc(cc3)N3CCN(C)CC3)c2n1
Show InChI InChI=1S/C22H23N7O/c1-28-9-11-29(12-10-28)16-5-3-15(4-6-16)20-21-18(26-27-20)14-24-22(25-21)17-13-23-8-7-19(17)30-2/h3-8,13-14H,9-12H2,1-2H3,(H,26,27)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499067
PNG
(US11014929, Example 105)
Show SMILES CN1CCN(CC1)c1ncc(cn1)-c1n[nH]c2cnc(nc12)-c1c(C)cc(CC#N)cc1F
Show InChI InChI=1S/C23H22FN9/c1-14-9-15(3-4-25)10-17(24)19(14)22-26-13-18-21(29-22)20(31-30-18)16-11-27-23(28-12-16)33-7-5-32(2)6-8-33/h9-13H,3,5-8H2,1-2H3,(H,30,31)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499073
PNG
(US11014929, Example 111)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cnc(nc12)-c1c(F)cc2CCNCc2c1C
Show InChI InChI=1S/C26H28FN7/c1-16-20-14-28-8-7-18(20)13-21(27)23(16)26-29-15-22-25(30-26)24(32-31-22)17-3-5-19(6-4-17)34-11-9-33(2)10-12-34/h3-6,13,15,28H,7-12,14H2,1-2H3,(H,31,32)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499076
PNG
(US11014929, Example 114)
Show SMILES CNC1CCc2c1cc(F)c(c2F)-c1ncc2[nH]nc(-c3cnc(nc3)N3CCN(C)CC3)c2n1
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499084
PNG
(US11014929, Example 122)
Show SMILES CNCc1cc(F)c(c(F)c1)-c1ncc2[nH]nc(-c3ccc(nc3)N3CCC(C)(O)CC3)c2n1
Show InChI InChI=1S/C24H25F2N7O/c1-24(34)5-7-33(8-6-24)19-4-3-15(12-28-19)21-22-18(31-32-21)13-29-23(30-22)20-16(25)9-14(11-27-2)10-17(20)26/h3-4,9-10,12-13,27,34H,5-8,11H2,1-2H3,(H,31,32)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498962
PNG
(US11014929, Example 3)
Show SMILES COc1ccccc1-c1ncc2[nH]nc(-c3ccc(cc3)N3CCN(C)CC3)c2n1
Show InChI InChI=1S/C23H24N6O/c1-28-11-13-29(14-12-28)17-9-7-16(8-10-17)21-22-19(26-27-21)15-24-23(25-22)18-5-3-4-6-20(18)30-2/h3-10,15H,11-14H2,1-2H3,(H,26,27)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498964
PNG
(US11014929, Example 5)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cnc(nc12)-c1cccnc1
Show InChI InChI=1S/C21H21N7/c1-27-9-11-28(12-10-27)17-6-4-15(5-7-17)19-20-18(25-26-19)14-23-21(24-20)16-3-2-8-22-13-16/h2-8,13-14H,9-12H2,1H3,(H,25,26)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498967
PNG
(US11014929, Example 7)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cnc(nc12)-c1ccc2CNC(=O)c2c1
Show InChI InChI=1S/C24H23N7O/c1-30-8-10-31(11-9-30)18-6-4-15(5-7-18)21-22-20(28-29-21)14-25-23(27-22)16-2-3-17-13-26-24(32)19(17)12-16/h2-7,12,14H,8-11,13H2,1H3,(H,26,32)(H,28,29)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498971
PNG
(US11014929, Example 11)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3ccc(cc3)N3CCN(C)CC3)c2n1
Show InChI InChI=1S/C23H23FN6O/c1-29-10-12-30(13-11-29)16-8-6-15(7-9-16)21-22-18(27-28-21)14-25-23(26-22)20-17(24)4-3-5-19(20)31-2/h3-9,14H,10-13H2,1-2H3,(H,27,28)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498984
PNG
(US11014929, Example 24)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3ccc(CN4CCOCC4)cc3)c2n1
Show InChI InChI=1S/C23H22FN5O2/c1-30-19-4-2-3-17(24)20(19)23-25-13-18-22(26-23)21(28-27-18)16-7-5-15(6-8-16)14-29-9-11-31-12-10-29/h2-8,13H,9-12,14H2,1H3,(H,27,28)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498994
PNG
(US11014929, Example 34)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3ccc(CC#N)cc3)c2n1
Show InChI InChI=1S/C20H14FN5O/c1-27-16-4-2-3-14(21)17(16)20-23-11-15-19(24-20)18(26-25-15)13-7-5-12(6-8-13)9-10-22/h2-8,11H,9H2,1H3,(H,25,26)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499000
PNG
(US11014929, Example 40)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3ccc(cc3)N3CCCCC3)c2n1
Show InChI InChI=1S/C23H22FN5O/c1-30-19-7-5-6-17(24)20(19)23-25-14-18-22(26-23)21(28-27-18)15-8-10-16(11-9-15)29-12-3-2-4-13-29/h5-11,14H,2-4,12-13H2,1H3,(H,27,28)
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US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499007
PNG
(US11014929, Example 45)
Show SMILES COc1ccc(F)c(F)c1-c1ncc2[nH]nc(-c3ccc(cc3)N3CCN(C)CC3)c2n1
Show InChI InChI=1S/C23H22F2N6O/c1-30-9-11-31(12-10-30)15-5-3-14(4-6-15)21-22-17(28-29-21)13-26-23(27-22)19-18(32-2)8-7-16(24)20(19)25/h3-8,13H,9-12H2,1-2H3,(H,28,29)
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US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499008
PNG
(US11014929, Example 46)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cnc(nc12)-c1cccc(C(N)=O)c1F
Show InChI InChI=1S/C23H22FN7O/c1-30-9-11-31(12-10-30)15-7-5-14(6-8-15)20-21-18(28-29-20)13-26-23(27-21)17-4-2-3-16(19(17)24)22(25)32/h2-8,13H,9-12H2,1H3,(H2,25,32)(H,28,29)
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US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499012
PNG
(US11014929, Example 50)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3ccnc(c3)N3CCNCC3)c2n1
Show InChI InChI=1S/C21H20FN7O/c1-30-16-4-2-3-14(22)18(16)21-25-12-15-20(26-21)19(28-27-15)13-5-6-24-17(11-13)29-9-7-23-8-10-29/h2-6,11-12,23H,7-10H2,1H3,(H,27,28)
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Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499014
PNG
(US11014929, Example 52)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3ccc(nc3)N3CCNCC3)c2n1
Show InChI InChI=1S/C21H20FN7O/c1-30-16-4-2-3-14(22)18(16)21-25-12-15-20(26-21)19(28-27-15)13-5-6-17(24-11-13)29-9-7-23-8-10-29/h2-6,11-12,23H,7-10H2,1H3,(H,27,28)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499021
PNG
(US11014929, Example 59)
Show SMILES Cc1cccc(F)c1-c1ncc2[nH]nc(-c3ccc(cc3)N3CCNCC3)c2n1
Show InChI InChI=1S/C22H21FN6/c1-14-3-2-4-17(23)19(14)22-25-13-18-21(26-22)20(28-27-18)15-5-7-16(8-6-15)29-11-9-24-10-12-29/h2-8,13,24H,9-12H2,1H3,(H,27,28)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499025
PNG
(US11014929, Example 63)
Show SMILES CNCc1cc(F)c(c(F)c1)-c1ncc2[nH]nc(-c3ccc(OC)cc3)c2n1
Show InChI InChI=1S/C20H17F2N5O/c1-23-9-11-7-14(21)17(15(22)8-11)20-24-10-16-19(25-20)18(27-26-16)12-3-5-13(28-2)6-4-12/h3-8,10,23H,9H2,1-2H3,(H,26,27)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499031
PNG
(US11014929, Example 69)
Show SMILES CNCc1cc(F)c(c(F)c1)-c1ncc2[nH]nc(-c3ccnc(N4CCOCC4)c3F)c2n1
Show InChI InChI=1S/C22H20F3N7O/c1-26-10-12-8-14(23)17(15(24)9-12)21-28-11-16-20(29-21)19(31-30-16)13-2-3-27-22(18(13)25)32-4-6-33-7-5-32/h2-3,8-9,11,26H,4-7,10H2,1H3,(H,30,31)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499040
PNG
(US11014929, Example 78)
Show SMILES CNCc1cc(C)c(c(F)c1)-c1ncc2[nH]nc(-c3cnn(C)c3)c2n1
Show InChI InChI=1S/C18H18FN7/c1-10-4-11(6-20-2)5-13(19)15(10)18-21-8-14-17(23-18)16(25-24-14)12-7-22-26(3)9-12/h4-5,7-9,20H,6H2,1-3H3,(H,24,25)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499044
PNG
(US11014929, Example 82)
Show SMILES Cn1cc(cn1)-c1n[nH]c2cnc(nc12)-c1c(F)cc(NC(=O)CN2CCCC2)cc1F
Show InChI InChI=1S/C21H20F2N8O/c1-30-10-12(8-25-30)19-20-16(28-29-19)9-24-21(27-20)18-14(22)6-13(7-15(18)23)26-17(32)11-31-4-2-3-5-31/h6-10H,2-5,11H2,1H3,(H,26,32)(H,28,29)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499049
PNG
(US11014929, Example 87)
Show SMILES CCNCc1cc(F)c(c(OC)c1)-c1ncc2[nH]nc(-c3cnn(C)c3)c2n1
Show InChI InChI=1S/C19H20FN7O/c1-4-21-7-11-5-13(20)16(15(6-11)28-3)19-22-9-14-18(24-19)17(26-25-14)12-8-23-27(2)10-12/h5-6,8-10,21H,4,7H2,1-3H3,(H,25,26)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499054
PNG
(US11014929, Example 92)
Show SMILES CN1CCN(CC1)c1ncc(cn1)-c1n[nH]c2cnc(nc12)-c1c(F)cc2CCNCc2c1F
Show InChI InChI=1S/C23H23F2N9/c1-33-4-6-34(7-5-33)23-28-9-14(10-29-23)20-21-17(31-32-20)12-27-22(30-21)18-16(24)8-13-2-3-26-11-15(13)19(18)25/h8-10,12,26H,2-7,11H2,1H3,(H,31,32)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499057
PNG
(US11014929, Example 95)
Show SMILES CS(=O)(=O)NCc1ccc(cc1)-c1n[nH]c2cnc(nc12)-c1c(F)cc2CCNCc2c1F
Show InChI InChI=1S/C22H20F2N6O2S/c1-33(31,32)27-9-12-2-4-13(5-3-12)20-21-17(29-30-20)11-26-22(28-21)18-16(23)8-14-6-7-25-10-15(14)19(18)24/h2-5,8,11,25,27H,6-7,9-10H2,1H3,(H,29,30)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499063
PNG
(US11014929, Example 101)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cnc(nc12)-c1ccc2cccnc2c1F
Show InChI InChI=1S/C25H22FN7/c1-32-11-13-33(14-12-32)18-7-4-17(5-8-18)23-24-20(30-31-23)15-28-25(29-24)19-9-6-16-3-2-10-27-22(16)21(19)26/h2-10,15H,11-14H2,1H3,(H,30,31)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499065
PNG
(US11014929, Example 103)
Show SMILES COc1ccncc1-c1ncc2[nH]nc(-c3ccc(nc3)N3CCN(C)CC3)c2n1
Show InChI InChI=1S/C21H22N8O/c1-28-7-9-29(10-8-28)18-4-3-14(11-23-18)19-20-16(26-27-19)13-24-21(25-20)15-12-22-6-5-17(15)30-2/h3-6,11-13H,7-10H2,1-2H3,(H,26,27)
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US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499074
PNG
(US11014929, Example 112)
Show SMILES CN1CCN(CC1)c1ccc(cn1)-c1n[nH]c2cnc(nc12)-c1c(C)cc2CCNCc2c1F
Show InChI InChI=1S/C25H27FN8/c1-15-11-16-5-6-27-13-18(16)22(26)21(15)25-29-14-19-24(30-25)23(32-31-19)17-3-4-20(28-12-17)34-9-7-33(2)8-10-34/h3-4,11-12,14,27H,5-10,13H2,1-2H3,(H,31,32)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499078
PNG
(US11014929, Example 116)
Show SMILES CNC1CCCc2c(F)c(c(F)cc12)-c1ncc2[nH]nc(-c3ccc(nc3)N3CCOCC3)c2n1
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499087
PNG
(US11014929, Example 125)
Show SMILES CCN1CCN(CC1)c1ccc(cc1)-c1n[nH]c2cnc(nc12)-c1c(C)cc(cc1F)C1CCCCN1
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498991
PNG
(US11014929, Example 31)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3ccc(cc3)C(=O)N3CCOCC3)c2n1
Show InChI InChI=1S/C23H20FN5O3/c1-31-18-4-2-3-16(24)19(18)22-25-13-17-21(26-22)20(28-27-17)14-5-7-15(8-6-14)23(30)29-9-11-32-12-10-29/h2-8,13H,9-12H2,1H3,(H,27,28)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499001
PNG
(US11014929, Example 41)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3ccc(CN)cc3)c2n1
Show InChI InChI=1S/C19H16FN5O/c1-26-15-4-2-3-13(20)16(15)19-22-10-14-18(23-19)17(25-24-14)12-7-5-11(9-21)6-8-12/h2-8,10H,9,21H2,1H3,(H,24,25)
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US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499002
PNG
(US11014929, Example 42)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3ccc(cc3)C(C)(C)C#N)c2n1
Show InChI InChI=1S/C22H18FN5O/c1-22(2,12-24)14-9-7-13(8-10-14)19-20-16(27-28-19)11-25-21(26-20)18-15(23)5-4-6-17(18)29-3/h4-11H,1-3H3,(H,27,28)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499020
PNG
(US11014929, Example 58)
Show SMILES Cc1cccc(F)c1-c1ncc2[nH]nc(-c3ccc(cc3)N3CCC(CC3)C#N)c2n1
Show InChI InChI=1S/C24H21FN6/c1-15-3-2-4-19(25)21(15)24-27-14-20-23(28-24)22(30-29-20)17-5-7-18(8-6-17)31-11-9-16(13-26)10-12-31/h2-8,14,16H,9-12H2,1H3,(H,29,30)
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US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499022
PNG
(US11014929, Example 60)
Show SMILES Cc1cccc(F)c1-c1ncc2[nH]nc(-c3ccc(cc3)N3CCC(O)C3)c2n1
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499026
PNG
(US11014929, Example 64)
Show SMILES CNCc1cc(F)c(c(F)c1)-c1ncc2[nH]nc(-c3cccc(c3)C#N)c2n1
Show InChI InChI=1S/C20H14F2N6/c1-24-9-12-6-14(21)17(15(22)7-12)20-25-10-16-19(26-20)18(28-27-16)13-4-2-3-11(5-13)8-23/h2-7,10,24H,9H2,1H3,(H,27,28)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499068
PNG
(US11014929, Example 106)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2n[nH]c3cnc(nc23)-c2c(F)ccc3CNCCc23)CC1
Show InChI InChI=1S/C26H28FN7/c1-33-10-12-34(13-11-33)16-17-2-4-18(5-3-17)24-25-22(31-32-24)15-29-26(30-25)23-20-8-9-28-14-19(20)6-7-21(23)27/h2-7,15,28H,8-14,16H2,1H3,(H,31,32)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499071
PNG
(US11014929, Example 109)
Show SMILES Cc1c2CNCCc2cc(F)c1-c1ncc2[nH]nc(-c3ccc(nc3)N3CCOCC3)c2n1
Show InChI InChI=1S/C24H24FN7O/c1-14-17-12-26-5-4-15(17)10-18(25)21(14)24-28-13-19-23(29-24)22(31-30-19)16-2-3-20(27-11-16)32-6-8-33-9-7-32/h2-3,10-11,13,26H,4-9,12H2,1H3,(H,30,31)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498988
PNG
(US11014929, Example 28)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3cccc(c3)N3CCCC3)c2n1
Show InChI InChI=1S/C22H20FN5O/c1-29-18-9-5-8-16(23)19(18)22-24-13-17-21(25-22)20(27-26-17)14-6-4-7-15(12-14)28-10-2-3-11-28/h4-9,12-13H,2-3,10-11H2,1H3,(H,26,27)
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Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498976
PNG
(US11014929, Example 16)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3cncnc3)c2n1
Show InChI InChI=1S/C16H11FN6O/c1-24-12-4-2-3-10(17)13(12)16-20-7-11-15(21-16)14(23-22-11)9-5-18-8-19-6-9/h2-8H,1H3,(H,22,23)
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Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498973
PNG
(US11014929, Example 13)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3ccccc3F)c2n1
Show InChI InChI=1S/C18H12F2N4O/c1-25-14-8-4-7-12(20)15(14)18-21-9-13-17(22-18)16(24-23-13)10-5-2-3-6-11(10)19/h2-9H,1H3,(H,23,24)
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275n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM499009
PNG
(US11014929, Example 47)
Show SMILES CNC(=O)c1cccc(c1F)-c1ncc2[nH]nc(-c3ccc(cc3)N3CCN(C)CC3)c2n1
Show InChI InChI=1S/C24H24FN7O/c1-26-24(33)18-5-3-4-17(20(18)25)23-27-14-19-22(28-23)21(30-29-19)15-6-8-16(9-7-15)32-12-10-31(2)11-13-32/h3-9,14H,10-13H2,1-2H3,(H,26,33)(H,29,30)
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275n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498982
PNG
(US11014929, Example 22)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3ccc(cc3)C(=O)N(C)C)c2n1
Show InChI InChI=1S/C21H18FN5O2/c1-27(2)21(28)13-9-7-12(8-10-13)18-19-15(25-26-18)11-23-20(24-19)17-14(22)5-4-6-16(17)29-3/h4-11H,1-3H3,(H,25,26)
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275n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498978
PNG
(US11014929, Example 18)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3ccc(cc3)C(F)(F)F)c2n1
Show InChI InChI=1S/C19H12F4N4O/c1-28-14-4-2-3-12(20)15(14)18-24-9-13-17(25-18)16(27-26-13)10-5-7-11(8-6-10)19(21,22)23/h2-9H,1H3,(H,26,27)
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275n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498993
PNG
(US11014929, Example 33)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3ccc(cc3)C3(CC3)N3CCOCC3)c2n1
Show InChI InChI=1S/C25H24FN5O2/c1-32-20-4-2-3-18(26)21(20)24-27-15-19-23(28-24)22(30-29-19)16-5-7-17(8-6-16)25(9-10-25)31-11-13-33-14-12-31/h2-8,15H,9-14H2,1H3,(H,29,30)
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275n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM498980
PNG
(US11014929, Example 20)
Show SMILES COc1cccc(F)c1-c1ncc2[nH]nc(-c3ccccc3C)c2n1
Show InChI InChI=1S/C19H15FN4O/c1-11-6-3-4-7-12(11)17-18-14(23-24-17)10-21-19(22-18)16-13(20)8-5-9-15(16)25-2/h3-10H,1-2H3,(H,23,24)
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750n/an/an/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...


US Patent US11014929 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%