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Patent code US11020380

Compile Data Set for Download or QSAR

Found 410 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CREB-binding protein


(Homo sapiens (Human))
BDBM437649
PNG
(2-cyclopropyl-6-(4-(6-methoxy-1'-methyl-6'-oxo-1',...)
Show SMILES COc1ccc(cn1)-c1cc(=O)n(C)cc1-c1cnn(c1)-c1cccc(C2CC2)c1C#N
Show InChI InChI=1S/C25H21N5O2/c1-29-15-22(20(10-25(29)31)17-8-9-24(32-2)27-12-17)18-13-28-30(14-18)23-5-3-4-19(16-6-7-16)21(23)11-26/h3-5,8-10,12-16H,6-7H2,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437650
PNG
(2-cyclopropyl-6-(4-(6-ethoxy-1'-methyl-6'-oxo-1',6...)
Show SMILES CCOc1ccc(cn1)-c1cc(=O)n(C)cc1-c1cnn(c1)-c1cccc(C2CC2)c1C#N
Show InChI InChI=1S/C26H23N5O2/c1-3-33-25-10-9-18(13-28-25)21-11-26(32)30(2)16-23(21)19-14-29-31(15-19)24-6-4-5-20(17-7-8-17)22(24)12-27/h4-6,9-11,13-17H,3,7-8H2,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437657
PNG
(2-cyclopropyl-6-(4-(6-(cyclopropylmethoxy)-1'-meth...)
Show SMILES Cn1cc(-c2cnn(c2)-c2cccc(C3CC3)c2C#N)c(cc1=O)-c1ccc(OCC2CC2)nc1
Show InChI InChI=1S/C28H25N5O2/c1-32-16-25(23(11-28(32)34)20-9-10-27(30-13-20)35-17-18-5-6-18)21-14-31-33(15-21)26-4-2-3-22(19-7-8-19)24(26)12-29/h2-4,9-11,13-16,18-19H,5-8,17H2,1H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437280
PNG
((S)-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl)...)
Show SMILES C[C@@H](c1ccccc1)n1cc(cn1)-c1ccc(=O)n(C)c1
Show InChI InChI=1S/C17H17N3O/c1-13(14-6-4-3-5-7-14)20-12-16(10-18-20)15-8-9-17(21)19(2)11-15/h3-13H,1-2H3/t13-/m0/s1
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437289
PNG
(5-(1-(1-(3-chlorophenyl)ethyl)-1H-pyrazol-4-yl)- 1...)
Show SMILES CC(c1cccc(Cl)c1)n1cc(cn1)-c1ccc(=O)n(C)c1
Show InChI InChI=1S/C17H16ClN3O/c1-12(13-4-3-5-16(18)8-13)21-11-15(9-19-21)14-6-7-17(22)20(2)10-14/h3-12H,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437302
PNG
(4-isopropoxy-1-methyl-5-(1-(1-phenylethyl)-1H- pyr...)
Show SMILES CC(C)Oc1cc(=O)n(C)cc1-c1cnn(c1)C(C)c1ccccc1
Show InChI InChI=1S/C20H23N3O2/c1-14(2)25-19-10-20(24)22(4)13-18(19)17-11-21-23(12-17)15(3)16-8-6-5-7-9-16/h5-15H,1-4H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437315
PNG
(4-cyclobutoxy-1-methyl-5-(1-(1-phenylethyl)-1H- py...)
Show SMILES CC(c1ccccc1)n1cc(cn1)-c1cn(C)c(=O)cc1OC1CCC1
Show InChI InChI=1S/C21H23N3O2/c1-15(16-7-4-3-5-8-16)24-13-17(12-22-24)19-14-23(2)21(25)11-20(19)26-18-9-6-10-18/h3-5,7-8,11-15,18H,6,9-10H2,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437319
PNG
(1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl)-4-(...)
Show SMILES CC(c1ccccc1)n1cc(cn1)-c1cn(C)c(=O)cc1-n1cccn1
Show InChI InChI=1S/C20H19N5O/c1-15(16-7-4-3-5-8-16)25-13-17(12-22-25)18-14-23(2)20(26)11-19(18)24-10-6-9-21-24/h3-15H,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437327
PNG
((R)-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol-4-yl)...)
Show SMILES C[C@H](c1ccccc1)n1cc(cn1)-c1cn(C)c(=O)cc1-n1cccn1
Show InChI InChI=1S/C20H19N5O/c1-15(16-7-4-3-5-8-16)25-13-17(12-22-25)18-14-23(2)20(26)11-19(18)24-10-6-9-21-24/h3-15H,1-2H3/t15-/m1/s1
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437328
PNG
(4-ethoxy-1-methyl-5-(1-(1-(p-tolyl)ethyl)-1H- pyra...)
Show SMILES CCOc1cc(=O)n(C)cc1-c1cnn(c1)C(C)c1ccc(C)cc1
Show InChI InChI=1S/C20H23N3O2/c1-5-25-19-10-20(24)22(4)13-18(19)17-11-21-23(12-17)15(3)16-8-6-14(2)7-9-16/h6-13,15H,5H2,1-4H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437333
PNG
(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-4- morpholin...)
Show SMILES Cn1cc(-c2cnn(Cc3ccccc3)c2)c(cc1=O)N1CCOCC1
Show InChI InChI=1S/C20H22N4O2/c1-22-15-18(19(11-20(22)25)23-7-9-26-10-8-23)17-12-21-24(14-17)13-16-5-3-2-4-6-16/h2-6,11-12,14-15H,7-10,13H2,1H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437344
PNG
(1-(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2...)
Show SMILES CN(C)C(=O)c1ccn(c1)-c1cc(=O)n(C)cc1-c1cnn(Cc2ccccc2)c1
Show InChI InChI=1S/C23H23N5O2/c1-25(2)23(30)18-9-10-27(14-18)21-11-22(29)26(3)16-20(21)19-12-24-28(15-19)13-17-7-5-4-6-8-17/h4-12,14-16H,13H2,1-3H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437364
PNG
(5-(1-(2,6-dichlorophenyl)-1H-pyrazol-4-yl)-4-ethox...)
Show SMILES CCOc1cc(=O)n(C)cc1-c1cnn(c1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C17H15Cl2N3O2/c1-3-24-15-7-16(23)21(2)10-12(15)11-8-20-22(9-11)17-13(18)5-4-6-14(17)19/h4-10H,3H2,1-2H3
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CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437368
PNG
(4-ethoxy-1-methyl-5-(1-(4-(1-methyl-1H-pyrazol-4-y...)
Show SMILES CCOc1cc(=O)n(C)cc1-c1cnn(Cc2ccc(cc2)-c2cnn(C)c2)c1
Show InChI InChI=1S/C22H23N5O2/c1-4-29-21-9-22(28)25(2)15-20(21)19-11-24-27(14-19)12-16-5-7-17(8-6-16)18-10-23-26(3)13-18/h5-11,13-15H,4,12H2,1-3H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437370
PNG
(4-ethoxy-1-methyl-5-(1-(1-(3-(1-methyl-1H-pyrazol-...)
Show SMILES CCOc1cc(=O)n(C)cc1-c1cnn(c1)C(C)c1cccc(c1)-c1cnn(C)c1
Show InChI InChI=1S/C23H25N5O2/c1-5-30-22-10-23(29)26(3)15-21(22)20-12-25-28(14-20)16(2)17-7-6-8-18(9-17)19-11-24-27(4)13-19/h6-16H,5H2,1-4H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437374
PNG
(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-4-(1-methyl-...)
Show SMILES Cn1cc(cn1)-c1cc(=O)n(C)cc1-c1cnn(Cc2ccccc2)c1
Show InChI InChI=1S/C20H19N5O/c1-23-14-19(18(8-20(23)26)16-9-21-24(2)12-16)17-10-22-25(13-17)11-15-6-4-3-5-7-15/h3-10,12-14H,11H2,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437386
PNG
(5-(1-benzyl-1H-pyrazol-4-yl)-4-(4-methoxyphenyl)-1...)
Show SMILES COc1ccc(cc1)-c1cc(=O)n(C)cc1-c1cnn(Cc2ccccc2)c1
Show InChI InChI=1S/C23H21N3O2/c1-25-16-22(19-13-24-26(15-19)14-17-6-4-3-5-7-17)21(12-23(25)27)18-8-10-20(28-2)11-9-18/h3-13,15-16H,14H2,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437404
PNG
(5-(1-isopropyl-1H-pyrazol-4-yl)-1-methyl-4- phenyl...)
Show SMILES CC(C)n1cc(cn1)-c1cn(C)c(=O)cc1-c1ccccc1
Show InChI InChI=1S/C18H19N3O/c1-13(2)21-11-15(10-19-21)17-12-20(3)18(22)9-16(17)14-7-5-4-6-8-14/h4-13H,1-3H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437406
PNG
(US10617680, Example 140 | US11020380, Example 140 ...)
Show SMILES COC(=O)Cn1cc(cn1)-c1cn(C)c(=O)cc1-c1ccccc1
Show InChI InChI=1S/C18H17N3O3/c1-20-11-16(14-9-19-21(10-14)12-18(23)24-2)15(8-17(20)22)13-6-4-3-5-7-13/h3-11H,12H2,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437418
PNG
(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-4-(1H-pyrazo...)
Show SMILES Cn1cc(-c2cnn(Cc3ccccc3)c2)c(cc1=O)-c1cn[nH]c1
Show InChI InChI=1S/C19H17N5O/c1-23-13-18(17(7-19(23)25)15-8-20-21-9-15)16-10-22-24(12-16)11-14-5-3-2-4-6-14/h2-10,12-13H,11H2,1H3,(H,20,21)
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437425
PNG
(2-(4-(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-...)
Show SMILES Cn1cc(-c2cnn(Cc3ccccc3)c2)c(cc1=O)-c1cnn(CC(O)=O)c1
Show InChI InChI=1S/C21H19N5O3/c1-24-13-19(17-9-22-25(12-17)10-15-5-3-2-4-6-15)18(7-20(24)27)16-8-23-26(11-16)14-21(28)29/h2-9,11-13H,10,14H2,1H3,(H,28,29)
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437433
PNG
(US10617680, Example 167 | US11020380, Example 167 ...)
Show SMILES Cn1cc(-c2cnn(Cc3ccccc3)c2)c(OCC#N)cc1=O
Show InChI InChI=1S/C18H16N4O2/c1-21-13-16(17(9-18(21)23)24-8-7-19)15-10-20-22(12-15)11-14-5-3-2-4-6-14/h2-6,9-10,12-13H,8,11H2,1H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437437
PNG
(5-[1-(2,2-Difluoro-cyclopropylmethyl)-1H-pyrazol-4...)
Show SMILES CCOc1cc(=O)n(C)cc1-c1cnn(CC2CC2(F)F)c1
Show InChI InChI=1S/C15H17F2N3O2/c1-3-22-13-4-14(21)19(2)9-12(13)10-6-18-20(7-10)8-11-5-15(11,16)17/h4,6-7,9,11H,3,5,8H2,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437438
PNG
(1-(5-(1-benzyl-1H-pyrazol-4-yl)-1-methyl-2-oxo-1,2...)
Show SMILES CNS(=O)(=O)C1CCN(C1)c1cc(=O)n(C)cc1-c1cnn(Cc2ccccc2)c1
Show InChI InChI=1S/C21H25N5O3S/c1-22-30(28,29)18-8-9-25(14-18)20-10-21(27)24(2)15-19(20)17-11-23-26(13-17)12-16-6-4-3-5-7-16/h3-7,10-11,13,15,18,22H,8-9,12,14H2,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437441
PNG
(4-methoxy-1-methyl-5-(1-(1-phenylethyl)-1H-pyrazol...)
Show SMILES COc1cc(=O)n(C)cc1-c1cnn(c1)C(C)c1ccccc1
Show InChI InChI=1S/C18H19N3O2/c1-13(14-7-5-4-6-8-14)21-11-15(10-19-21)16-12-20(2)18(22)9-17(16)23-3/h4-13H,1-3H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437446
PNG
(4-Ethoxy-5-[1-(2-methanesulfonyl-phenyl)-1H-pyrazo...)
Show SMILES CCOc1cc(=O)n(C)cc1-c1cnn(c1)-c1ccccc1S(C)(=O)=O
Show InChI InChI=1S/C18H19N3O4S/c1-4-25-16-9-18(22)20(2)12-14(16)13-10-19-21(11-13)15-7-5-6-8-17(15)26(3,23)24/h5-12H,4H2,1-3H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437447
PNG
(4-ethoxy-1-methyl-5-(1-(1-(methylsulfonyl)piperidi...)
Show SMILES CCOc1cc(=O)n(C)cc1-c1cnn(c1)C1CCCN(C1)S(C)(=O)=O
Show InChI InChI=1S/C17H24N4O4S/c1-4-25-16-8-17(22)19(2)12-15(16)13-9-18-21(10-13)14-6-5-7-20(11-14)26(3,23)24/h8-10,12,14H,4-7,11H2,1-3H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437449
PNG
(2-[4-(4-Ethoxy-1-methyl-6-oxo-1,6-dihydro-pyridin-...)
Show SMILES CCOc1cc(=O)n(C)cc1-c1cnn(c1)-c1cc(Oc2ccccc2)ccc1C#N
Show InChI InChI=1S/C24H20N4O3/c1-3-30-23-12-24(29)27(2)16-21(23)18-14-26-28(15-18)22-11-20(10-9-17(22)13-25)31-19-7-5-4-6-8-19/h4-12,14-16H,3H2,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437458
PNG
(5-[1-(2,2-Difluoro-cyclopropylmethyl)-1H-pyrazol-4...)
Show SMILES Cn1cc(cn1)-c1cc(=O)n(C)cc1-c1cnn(CC2CC2(F)F)c1
Show InChI InChI=1S/C17H17F2N5O/c1-22-10-15(14(3-16(22)25)11-5-20-23(2)7-11)12-6-21-24(8-12)9-13-4-17(13,18)19/h3,5-8,10,13H,4,9H2,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437465
PNG
(2-Benzyl-4-(1,5-dimethyl-6-oxo-1,6-dihydro-pyridin...)
Show SMILES CCOC(=O)c1c(cnn1Cc1ccccc1)-c1cc(C)c(=O)n(C)c1
Show InChI InChI=1S/C20H21N3O3/c1-4-26-20(25)18-17(16-10-14(2)19(24)22(3)13-16)11-21-23(18)12-15-8-6-5-7-9-15/h5-11,13H,4,12H2,1-3H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437493
PNG
(2-[4-(1'-Methyl-6'-oxo-1',6'-dihydro-[3,4']bipyrid...)
Show SMILES Cn1cc(-c2cnn(c2)-c2ccccc2C(O)=O)c(cc1=O)-c1cccnc1
Show InChI InChI=1S/C21H16N4O3/c1-24-13-18(17(9-20(24)26)14-5-4-8-22-10-14)15-11-23-25(12-15)19-7-3-2-6-16(19)21(27)28/h2-13H,1H3,(H,27,28)
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437496
PNG
(2-[4-(6-Ethoxy-1'-methyl-6'-oxo-1',6'-dihydro- [3,...)
Show SMILES CCOc1ccc(cn1)-c1cc(=O)n(C)cc1-c1cnn(c1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C23H20N4O4/c1-3-31-21-9-8-15(11-24-21)18-10-22(28)26(2)14-19(18)16-12-25-27(13-16)20-7-5-4-6-17(20)23(29)30/h4-14H,3H2,1-2H3,(H,29,30)
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437502
PNG
(2-[4-(6-Isobutoxy-1'-methyl-6'-oxo-1',6'-dihydro- ...)
Show SMILES CC(C)COc1ccc(cn1)-c1cc(=O)n(C)cc1-c1cnn(c1)-c1ccccc1C#N
Show InChI InChI=1S/C25H23N5O2/c1-17(2)16-32-24-9-8-19(12-27-24)21-10-25(31)29(3)15-22(21)20-13-28-30(14-20)23-7-5-4-6-18(23)11-26/h4-10,12-15,17H,16H2,1-3H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437503
PNG
(2-[4-(1'-Methyl-6'-oxo-1',6'-dihydro-[3,4']bipyrid...)
Show SMILES Cn1cc(-c2cnn(c2)-c2ccccc2C#N)c(cc1=O)-c1cccnc1
Show InChI InChI=1S/C21H15N5O/c1-25-14-19(18(9-21(25)27)16-6-4-8-23-11-16)17-12-24-26(13-17)20-7-3-2-5-15(20)10-22/h2-9,11-14H,1H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437508
PNG
(2-(4-(5-methoxy-1'-methyl-6'-oxo-1',6'-dihydro-[3,...)
Show SMILES COc1cncc(c1)-c1cc(=O)n(C)cc1-c1cnn(c1)-c1ccccc1C#N
Show InChI InChI=1S/C22H17N5O2/c1-26-14-20(19(8-22(26)28)16-7-18(29-2)12-24-10-16)17-11-25-27(13-17)21-6-4-3-5-15(21)9-23/h3-8,10-14H,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437510
PNG
(2-{4-[4-(2-Methoxy-pyrimidin-5-yl)-1-methyl-6-oxo-...)
Show SMILES COc1ncc(cn1)-c1cc(=O)n(C)cc1-c1cnn(c1)-c1ccccc1C#N
Show InChI InChI=1S/C21H16N6O2/c1-26-13-18(17(7-20(26)28)15-9-23-21(29-2)24-10-15)16-11-25-27(12-16)19-6-4-3-5-14(19)8-22/h3-7,9-13H,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437515
PNG
(2-(4-(4-ethoxy-1-methyl-6-oxo-1,6-dihydropyridin-3...)
Show SMILES CCOc1cc(=O)n(C)cc1-c1cnn(c1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C18H17N3O4/c1-3-25-16-8-17(22)20(2)11-14(16)12-9-19-21(10-12)15-7-5-4-6-13(15)18(23)24/h4-11H,3H2,1-2H3,(H,23,24)
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437521
PNG
(2-[4-(1,5-Dimethyl-6-oxo-1,6-dihydro-pyridin-3-yl)...)
Show SMILES Cc1cc(cn(C)c1=O)-c1cnn(c1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C17H15N3O3/c1-11-7-12(9-19(2)16(11)21)13-8-18-20(10-13)15-6-4-3-5-14(15)17(22)23/h3-10H,1-2H3,(H,22,23)
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437533
PNG
(4-Methoxy-2-[4-(1-methyl-6-oxo-4-phenyl-1,6-dihydr...)
Show SMILES COc1ccc(C(O)=O)c(c1)-n1cc(cn1)-c1cn(C)c(=O)cc1-c1ccccc1
Show InChI InChI=1S/C23H19N3O4/c1-25-14-20(19(11-22(25)27)15-6-4-3-5-7-15)16-12-24-26(13-16)21-10-17(30-2)8-9-18(21)23(28)29/h3-14H,1-2H3,(H,28,29)
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437542
PNG
(2-Chloro-6-[4-(1,1''-dimethyl-6,2''-dioxo-1,6,1'',...)
Show SMILES Cn1ccc(cc1=O)-c1cc(=O)n(C)cc1-c1cnn(c1)-c1cccc(Cl)c1C#N
Show InChI InChI=1S/C22H16ClN5O2/c1-26-7-6-14(8-21(26)29)16-9-22(30)27(2)13-18(16)15-11-25-28(12-15)20-5-3-4-19(23)17(20)10-24/h3-9,11-13H,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437543
PNG
(2-Chloro-6-[4-(6-methoxy-1'-methyl-6'-oxo-1',6'-di...)
Show SMILES COc1ccc(cn1)-c1cc(=O)n(C)cc1-c1cnn(c1)-c1cccc(Cl)c1C#N
Show InChI InChI=1S/C22H16ClN5O2/c1-27-13-18(16(8-22(27)29)14-6-7-21(30-2)25-10-14)15-11-26-28(12-15)20-5-3-4-19(23)17(20)9-24/h3-8,10-13H,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437363
PNG
(5-(1-(2-chlorophenyl)-1H-pyrazol-4-yl)-4-ethoxy-1-...)
Show SMILES CCOc1cc(=O)n(C)cc1-c1cnn(c1)-c1ccccc1Cl
Show InChI InChI=1S/C17H16ClN3O2/c1-3-23-16-8-17(22)20(2)11-13(16)12-9-19-21(10-12)15-7-5-4-6-14(15)18/h4-11H,3H2,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437561
PNG
(N-cyano-2-(4-(1-methyl-4-(2-(methylamino)pyrimidin...)
Show SMILES CNc1ncc(cn1)-c1cc(=O)n(C)cc1-c1cnn(c1)-c1ccccc1C(=O)NC#N
Show InChI InChI=1S/C22H18N8O2/c1-24-22-25-8-14(9-26-22)17-7-20(31)29(2)12-18(17)15-10-28-30(11-15)19-6-4-3-5-16(19)21(32)27-13-23/h3-12H,1-2H3,(H,27,32)(H,24,25,26)
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US Patent
n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437562
PNG
(N-cyano-2-(4-(6-ethoxy-1'-methyl-6'-oxo-1',6'-dihy...)
Show SMILES CCOc1ccc(cn1)-c1cc(=O)n(C)cc1-c1cnn(c1)-c1ccccc1C(=O)NC#N
Show InChI InChI=1S/C24H20N6O3/c1-3-33-22-9-8-16(11-26-22)19-10-23(31)29(2)14-20(19)17-12-28-30(13-17)21-7-5-4-6-18(21)24(32)27-15-25/h4-14H,3H2,1-2H3,(H,27,32)
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US Patent
n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437570
PNG
(N-[(dimethylamino)sulfonyl]-{2-[4-(4-cyclopropyl-1...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1ccccc1-n1cc(cn1)-c1cn(C)c(=O)cc1C1CC1
Show InChI InChI=1S/C21H23N5O4S/c1-24(2)31(29,30)23-21(28)16-6-4-5-7-19(16)26-12-15(11-22-26)18-13-25(3)20(27)10-17(18)14-8-9-14/h4-7,10-14H,8-9H2,1-3H3,(H,23,28)
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437581
PNG
(5-(1-(2-chlorophenyl)-1H-pyrazol-4-yl)-4-(2- metho...)
Show SMILES COc1ncc(cn1)-c1cc(=O)n(C)cc1-c1cnn(c1)-c1ccccc1Cl
Show InChI InChI=1S/C20H16ClN5O2/c1-25-12-16(14-10-24-26(11-14)18-6-4-3-5-17(18)21)15(7-19(25)27)13-8-22-20(28-2)23-9-13/h3-12H,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437582
PNG
(5'-(1-(2-chlorophenyl)-1H-pyrazol-4-yl)-6-methoxy-...)
Show SMILES COc1ncc(cc1C)-c1cc(=O)n(C)cc1-c1cnn(c1)-c1ccccc1Cl
Show InChI InChI=1S/C22H19ClN4O2/c1-14-8-15(10-24-22(14)29-3)17-9-21(28)26(2)13-18(17)16-11-25-27(12-16)20-7-5-4-6-19(20)23/h4-13H,1-3H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437588
PNG
(2-chloro-6-[4-[4-[2-(cyclopropylamino)pyrimidin-5-...)
Show SMILES Cn1cc(-c2cnn(c2)-c2cccc(Cl)c2C#N)c(cc1=O)-c1cnc(NC2CC2)nc1
Show InChI InChI=1S/C23H18ClN7O/c1-30-13-19(15-11-28-31(12-15)21-4-2-3-20(24)18(21)8-25)17(7-22(30)32)14-9-26-23(27-10-14)29-16-5-6-16/h2-4,7,9-13,16H,5-6H2,1H3,(H,26,27,29)
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437598
PNG
(2-chloro-6-(4-(1-methyl-4-(2-(methylamino)pyrimidi...)
Show SMILES CNc1ncc(cn1)-c1cc(=O)n(C)cc1-c1cnn(c1)-c1cccc(Cl)c1C#N
Show InChI InChI=1S/C21H16ClN7O/c1-24-21-25-8-13(9-26-21)15-6-20(30)28(2)12-17(15)14-10-27-29(11-14)19-5-3-4-18(22)16(19)7-23/h3-6,8-12H,1-2H3,(H,24,25,26)
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM437603
PNG
(2-chloro-6-(4-(1-methyl-4-(2-(4-methylpiperazin-1-...)
Show SMILES CN1CCN(CC1)c1ncc(cn1)-c1cc(=O)n(C)cc1-c1cnn(c1)-c1cccc(Cl)c1C#N
Show InChI InChI=1S/C25H23ClN8O/c1-31-6-8-33(9-7-31)25-28-12-17(13-29-25)19-10-24(35)32(2)16-21(19)18-14-30-34(15-18)23-5-3-4-22(26)20(23)11-27/h3-5,10,12-16H,6-9H2,1-2H3
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n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
The CBP-inhibitory activity of the compounds described herein was determined by calculating the IC50. More specifically, CBP inhibitor activity was a...


US Patent US11020380 (2021)

More data for this
Ligand-Target Pair
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