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Patent code US11020381

Compile Data Set for Download or QSAR
Found 174 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499334
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)phenox...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(F)c(COc2cccc(c2)-c2ccc(OCC3CC3)nc2)cc1F
Show InChI InChI=1S/C24H22F2N2O5S/c1-34(30,31)28-24(29)20-11-21(25)18(10-22(20)26)14-32-19-4-2-3-16(9-19)17-7-8-23(27-12-17)33-13-15-5-6-15/h2-4,7-12,15H,5-6,13-14H2,1H3,(H,28,29)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent




US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499324
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)phenox...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ccc(OCC3CC3)nc2)c(F)c1
Show InChI InChI=1S/C24H23FN2O5S/c1-33(29,30)27-24(28)18-7-8-20(22(25)12-18)15-31-21-4-2-3-17(11-21)19-9-10-23(26-13-19)32-14-16-5-6-16/h2-4,7-13,16H,5-6,14-15H2,1H3,(H,27,28)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent




US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499388
PNG
(4-((3-(5- (cyclopropylmethyl)isoxazol-3- yl)phenox...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2cc(CC3CC3)on2)c(F)c1
Show InChI InChI=1S/C22H21FN2O5S/c1-31(27,28)25-22(26)16-7-8-17(20(23)11-16)13-29-18-4-2-3-15(10-18)21-12-19(30-24-21)9-14-5-6-14/h2-4,7-8,10-12,14H,5-6,9,13H2,1H3,(H,25,26)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent




US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499334
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)phenox...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(F)c(COc2cccc(c2)-c2ccc(OCC3CC3)nc2)cc1F
Show InChI InChI=1S/C24H22F2N2O5S/c1-34(30,31)28-24(29)20-11-21(25)18(10-22(20)26)14-32-19-4-2-3-16(9-19)17-7-8-23(27-12-17)33-13-15-5-6-15/h2-4,7-12,15H,5-6,13-14H2,1H3,(H,28,29)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent




US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499313
PNG
(4-((3-(6- (cydopropylmethoxy)pyridin-3- yl)phenoxy...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ccc(OCC3CC3)nc2)cc1
Show InChI InChI=1S/C24H24N2O5S/c1-32(28,29)26-24(27)19-9-7-18(8-10-19)15-30-22-4-2-3-20(13-22)21-11-12-23(25-14-21)31-16-17-5-6-17/h2-4,7-14,17H,5-6,15-16H2,1H3,(H,26,27)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent




US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499313
PNG
(4-((3-(6- (cydopropylmethoxy)pyridin-3- yl)phenoxy...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ccc(OCC3CC3)nc2)cc1
Show InChI InChI=1S/C24H24N2O5S/c1-32(28,29)26-24(27)19-9-7-18(8-10-19)15-30-22-4-2-3-20(13-22)21-11-12-23(25-14-21)31-16-17-5-6-17/h2-4,7-14,17H,5-6,15-16H2,1H3,(H,26,27)
PDB

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n/an/a<500n/an/an/an/an/an/a



RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499335
PNG
(3-fluoro-N-(methylsulfonyl)-4- ((3-(6-((tetrahydro...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ccc(OCC3CCOCC3)nc2)c(F)c1
Show InChI InChI=1S/C26H27FN2O6S/c1-36(31,32)29-26(30)20-5-6-22(24(27)14-20)17-34-23-4-2-3-19(13-23)21-7-8-25(28-15-21)35-16-18-9-11-33-12-10-18/h2-8,13-15,18H,9-12,16-17H2,1H3,(H,29,30)
PDB

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n/an/a<500n/an/an/an/an/an/a



RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499341
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)-5-flu...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(F)c(COc2cc(F)cc(c2)-c2ccc(OCC3CC3)nc2)cc1F
Show InChI InChI=1S/C24H21F3N2O5S/c1-35(31,32)29-24(30)20-10-21(26)17(8-22(20)27)13-33-19-7-16(6-18(25)9-19)15-4-5-23(28-11-15)34-12-14-2-3-14/h4-11,14H,2-3,12-13H2,1H3,(H,29,30)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499344
PNG
(4-((3-cyclopropyl-5-(6- (cyclopropylmethoxy)pyridi...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(cc(c2)-c2ccc(OCC3CC3)nc2)C2CC2)cc1
Show InChI InChI=1S/C27H28N2O5S/c1-35(31,32)29-27(30)21-6-4-19(5-7-21)16-33-25-13-23(20-8-9-20)12-24(14-25)22-10-11-26(28-15-22)34-17-18-2-3-18/h4-7,10-15,18,20H,2-3,8-9,16-17H2,1H3,(H,29,30)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499349
PNG
(3-cyano-4-((3-(6- (cyclopropylmethoxy)pyridin-3- y...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ccc(OCC3CC3)nc2)c(c1)C#N
Show InChI InChI=1S/C25H23N3O5S/c1-34(30,31)28-25(29)19-7-8-21(22(11-19)13-26)16-32-23-4-2-3-18(12-23)20-9-10-24(27-14-20)33-15-17-5-6-17/h2-4,7-12,14,17H,5-6,15-16H2,1H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499355
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)-4-flu...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2ccc(F)c(c2)-c2ccc(OCC3CC3)nc2)c(F)c1
Show InChI InChI=1S/C24H22F2N2O5S/c1-34(30,31)28-24(29)16-4-5-18(22(26)10-16)14-32-19-7-8-21(25)20(11-19)17-6-9-23(27-12-17)33-13-15-2-3-15/h4-12,15H,2-3,13-14H2,1H3,(H,28,29)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499360
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)phenox...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ccc(OCC3CCC3)nc2)c(F)c1
Show InChI InChI=1S/C25H25FN2O5S/c1-34(30,31)28-25(29)19-8-9-21(23(26)13-19)16-32-22-7-3-6-18(12-22)20-10-11-24(27-14-20)33-15-17-4-2-5-17/h3,6-14,17H,2,4-5,15-16H2,1H3,(H,28,29)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499369
PNG
(4-((3-(5- (cyclopropylmethoxy)pyridin-3- yl)phenox...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2cncc(OCC3CC3)c2)cc1
Show InChI InChI=1S/C24H24N2O5S/c1-32(28,29)26-24(27)19-9-7-18(8-10-19)15-30-22-4-2-3-20(11-22)21-12-23(14-25-13-21)31-16-17-5-6-17/h2-4,7-14,17H,5-6,15-16H2,1H3,(H,26,27)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499384
PNG
(4-(((4'-(cyclopropylmethoxy)- [1,1'-biphenyl]-3- y...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ccc(OCC3CC3)cc2)cc1
Show InChI InChI=1S/C25H25NO5S/c1-32(28,29)26-25(27)21-9-7-19(8-10-21)17-31-24-4-2-3-22(15-24)20-11-13-23(14-12-20)30-16-18-5-6-18/h2-4,7-15,18H,5-6,16-17H2,1H3,(H,26,27)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499386
PNG
(4-(cyclopropylmethoxy)-3'-((2- fluoro-4- ((methyls...)
Show SMILES CN(C)C(=O)c1cc(ccc1OCC1CC1)-c1cccc(OCc2ccc(cc2F)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C28H29FN2O6S/c1-31(2)28(33)24-14-20(11-12-26(24)37-16-18-7-8-18)19-5-4-6-23(13-19)36-17-22-10-9-21(15-25(22)29)27(32)30-38(3,34)35/h4-6,9-15,18H,7-8,16-17H2,1-3H3,(H,30,32)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499394
PNG
(4-((3-(6-(cyclobutylmethoxy)-2- methylpyridin-3-yl...)
Show SMILES Cc1nc(OCC2CCC2)ccc1-c1cc(F)cc(OCc2ccc(cc2)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C26H27FN2O5S/c1-17-24(10-11-25(28-17)34-16-18-4-3-5-18)21-12-22(27)14-23(13-21)33-15-19-6-8-20(9-7-19)26(30)29-35(2,31)32/h6-14,18H,3-5,15-16H2,1-2H3,(H,29,30)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499399
PNG
(4-((3-(6-(cyclopropylmethoxy)- 4-methylpyridin-3-y...)
Show SMILES Cc1cc(OCC2CC2)ncc1-c1cc(F)cc(OCc2ccc(cc2)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C25H25FN2O5S/c1-16-9-24(33-15-17-3-4-17)27-13-23(16)20-10-21(26)12-22(11-20)32-14-18-5-7-19(8-6-18)25(29)28-34(2,30)31/h5-13,17H,3-4,14-15H2,1-2H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499402
PNG
(4-((3-(5-chloro-6- (cyclopropylmethoxy)pyridin-3- ...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(F)cc(c2)-c2cnc(OCC3CC3)c(Cl)c2)c(F)c1
Show InChI InChI=1S/C24H21ClF2N2O5S/c1-35(31,32)29-23(30)15-4-5-16(22(27)9-15)13-33-20-7-17(6-19(26)10-20)18-8-21(25)24(28-11-18)34-12-14-2-3-14/h4-11,14H,2-3,12-13H2,1H3,(H,29,30)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499412
PNG
(4-((3-(6- (cyclopropylmethoxy) pyridin-3-yl)- 5-(p...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(cc(c2)-c2cncnc2)-c2ccc(OCC3CC3)nc2)cc1
Show InChI InChI=1S/C28H26N4O5S/c1-38(34,35)32-28(33)21-6-4-20(5-7-21)16-36-26-11-23(10-24(12-26)25-13-29-18-30-14-25)22-8-9-27(31-15-22)37-17-19-2-3-19/h4-15,18-19H,2-3,16-17H2,1H3,(H,32,33)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499423
PNG
(4-((3-(5-(cyclopropylmethoxy)- 3-fluoropyridin-2-y...)
Show SMILES Cc1cc(OCC2CC2)cnc1-c1cc(F)cc(OCc2ccc(cc2)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C25H25FN2O5S/c1-16-9-23(33-15-17-3-4-17)13-27-24(16)20-10-21(26)12-22(11-20)32-14-18-5-7-19(8-6-18)25(29)28-34(2,30)31/h5-13,17H,3-4,14-15H2,1-2H3,(H,28,29)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499425
PNG
(4-((3-(5-(cyclobutylmethoxy)-3- methylpyridin-2-yl...)
Show SMILES Cc1cc(OCC2CCC2)cnc1-c1cc(F)cc(OCc2ccc(cc2)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C26H27FN2O5S/c1-17-10-24(34-15-18-4-3-5-18)14-28-25(17)21-11-22(27)13-23(12-21)33-16-19-6-8-20(9-7-19)26(30)29-35(2,31)32/h6-14,18H,3-5,15-16H2,1-2H3,(H,29,30)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499426
PNG
(4-((3-(5-(cyclopropylmethoxy)-3- methylpyridin-2- ...)
Show SMILES Cc1cc(OCC2CCC2)cnc1-c1cccc(OCc2ccc(cc2F)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C26H27FN2O5S/c1-17-11-23(33-15-18-5-3-6-18)14-28-25(17)19-7-4-8-22(12-19)34-16-21-10-9-20(13-24(21)27)26(30)29-35(2,31)32/h4,7-14,18H,3,5-6,15-16H2,1-2H3,(H,29,30)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499440
PNG
(4-((3-(2- ((cyclopropylmethyl) (methyl)amino) pyri...)
Show SMILES CN(CC1CC1)c1cc(ccn1)-c1cccc(OCc2ccc(cc2F)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C25H26FN3O4S/c1-29(15-17-6-7-17)24-14-19(10-11-27-24)18-4-3-5-22(12-18)33-16-21-9-8-20(13-23(21)26)25(30)28-34(2,31)32/h3-5,8-14,17H,6-7,15-16H2,1-2H3,(H,28,30)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499441
PNG
(4-((3-(5-(cyclobutylmethoxy) pyrazin- 2-yl)phenoxy...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2cnc(OCC3CCC3)cn2)cc1
Show InChI InChI=1S/C24H25N3O5S/c1-33(29,30)27-24(28)19-10-8-18(9-11-19)15-31-21-7-3-6-20(12-21)22-13-26-23(14-25-22)32-16-17-4-2-5-17/h3,6-14,17H,2,4-5,15-16H2,1H3,(H,27,28)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499445
PNG
(4-((3-(6-(cyclopropylmethoxy) pyrazin-2-yl)- 5-flu...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(F)cc(c2)-c2cncc(OCC3CC3)n2)cc1
Show InChI InChI=1S/C23H22FN3O5S/c1-33(29,30)27-23(28)17-6-4-16(5-7-17)13-31-20-9-18(8-19(24)10-20)21-11-25-12-22(26-21)32-14-15-2-3-15/h4-12,15H,2-3,13-14H2,1H3,(H,27,28)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499449
PNG
(4-((3-(5- (cyclopropylmethoxy)pyrimidin- 4-yl)phen...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2cc(OCC3CC3)ncn2)cc1
Show InChI InChI=1S/C23H23N3O5S/c1-32(28,29)26-23(27)18-9-7-17(8-10-18)13-30-20-4-2-3-19(11-20)21-12-22(25-15-24-21)31-14-16-5-6-16/h2-4,7-12,15-16H,5-6,13-14H2,1H3,(H,26,27)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499458
PNG
(4-((3-(2- ((cyclopropylmethyl) (methyl)amino) pyri...)
Show SMILES CN(CC1CC1)c1ncc(cn1)-c1cccc(OCc2ccc(cc2F)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C24H25FN4O4S/c1-29(14-16-6-7-16)24-26-12-20(13-27-24)17-4-3-5-21(10-17)33-15-19-9-8-18(11-22(19)25)23(30)28-34(2,31)32/h3-5,8-13,16H,6-7,14-15H2,1-2H3,(H,28,30)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499470
PNG
(4-((3-(6-(cyclopropyl- methoxy)pyridin- 3-yl)-5-fl...)
Show SMILES Fc1cc(OCc2ccc(cc2)C(=O)NS(=O)(=O)C2CC2)cc(c1)-c1ccc(OCC2CC2)nc1
Show InChI InChI=1S/C26H25FN2O5S/c27-22-11-21(20-7-10-25(28-14-20)34-16-17-1-2-17)12-23(13-22)33-15-18-3-5-19(6-4-18)26(30)29-35(31,32)24-8-9-24/h3-7,10-14,17,24H,1-2,8-9,15-16H2,(H,29,30)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499472
PNG
(4-((3-(6-(cyclopropyl- methoxy)pyridin- 3-yl)-5-fl...)
Show SMILES Fc1cc(OCc2ccc(cc2)C(=O)NS(=O)(=O)c2cccs2)cc(c1)-c1ccc(OCC2CC2)nc1
Show InChI InChI=1S/C27H23FN2O5S2/c28-23-12-22(21-9-10-25(29-15-21)35-17-18-3-4-18)13-24(14-23)34-16-19-5-7-20(8-6-19)27(31)30-37(32,33)26-2-1-11-36-26/h1-2,5-15,18H,3-4,16-17H2,(H,30,31)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499312
PNG
(N-(methylsulfonyl)-4-((3-(6- ((tetrahydro-2H-pyran...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ccc(OCC3CCOCC3)nc2)cc1
Show InChI InChI=1S/C26H28N2O6S/c1-35(30,31)28-26(29)21-7-5-19(6-8-21)17-33-24-4-2-3-22(15-24)23-9-10-25(27-16-23)34-18-20-11-13-32-14-12-20/h2-10,15-16,20H,11-14,17-18H2,1H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499330
PNG
(5-chloro-4-((3-(6- (cyclopropylmethoxy)pyridin-3- ...)
Show SMILES Fc1cc(COc2cccc(c2)-c2ccc(OCC3CC3)nc2)c(Cl)cc1C(=O)NS(=O)(=O)c1cccs1
Show InChI InChI=1S/C27H22ClFN2O5S2/c28-23-13-22(27(32)31-38(33,34)26-5-2-10-37-26)24(29)12-20(23)16-35-21-4-1-3-18(11-21)19-8-9-25(30-14-19)36-15-17-6-7-17/h1-5,8-14,17H,6-7,15-16H2,(H,31,32)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499356
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)-4-flu...)
Show SMILES Fc1ccc(OCc2ccc(cc2F)C(=O)NS(=O)(=O)C2CC2)cc1-c1ccc(OCC2CC2)nc1
Show InChI InChI=1S/C26H24F2N2O5S/c27-23-9-6-20(12-22(23)18-5-10-25(29-13-18)35-14-16-1-2-16)34-15-19-4-3-17(11-24(19)28)26(31)30-36(32,33)21-7-8-21/h3-6,9-13,16,21H,1-2,7-8,14-15H2,(H,30,31)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499362
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)phenox...)
Show SMILES CC(C)S(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ccc(OCC3CC3)nc2)c(F)c1
Show InChI InChI=1S/C26H27FN2O5S/c1-17(2)35(31,32)29-26(30)20-8-9-22(24(27)13-20)16-33-23-5-3-4-19(12-23)21-10-11-25(28-14-21)34-15-18-6-7-18/h3-5,8-14,17-18H,6-7,15-16H2,1-2H3,(H,29,30)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499365
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)phenox...)
Show SMILES Fc1cc(ccc1COc1cccc(c1)-c1ccc(OCC2CC2)nc1)C(=O)NS(=O)(=O)c1cccs1
Show InChI InChI=1S/C27H23FN2O5S2/c28-24-14-20(27(31)30-37(32,33)26-5-2-12-36-26)8-9-22(24)17-34-23-4-1-3-19(13-23)21-10-11-25(29-15-21)35-16-18-6-7-18/h1-5,8-15,18H,6-7,16-17H2,(H,30,31)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499368
PNG
(4-((3-(2- (cyclopropylmethoxy)pyridin-3- yl)phenox...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2cccnc2OCC2CC2)cc1
Show InChI InChI=1S/C24H24N2O5S/c1-32(28,29)26-23(27)19-11-9-18(10-12-19)15-30-21-5-2-4-20(14-21)22-6-3-13-25-24(22)31-16-17-7-8-17/h2-6,9-14,17H,7-8,15-16H2,1H3,(H,26,27)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499378
PNG
(4-((3-(5- (cyclopropylmethoxy)pyrazin-2- yl)phenox...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2cnc(OCC3CC3)cn2)cc1
Show InChI InChI=1S/C23H23N3O5S/c1-32(28,29)26-23(27)18-9-7-17(8-10-18)14-30-20-4-2-3-19(11-20)21-12-25-22(13-24-21)31-15-16-5-6-16/h2-4,7-13,16H,5-6,14-15H2,1H3,(H,26,27)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499383
PNG
(4-((3-(5- (cyclopropylmethoxy)pyrimidin- 2-yl)phen...)
Show SMILES O=C(NS(=O)(=O)C1CC1)c1ccc(COc2cccc(c2)-c2ncc(OCC3CC3)cn2)cc1
Show InChI InChI=1S/C25H25N3O5S/c29-25(28-34(30,31)23-10-11-23)19-8-6-18(7-9-19)15-32-21-3-1-2-20(12-21)24-26-13-22(14-27-24)33-16-17-4-5-17/h1-3,6-9,12-14,17,23H,4-5,10-11,15-16H2,(H,28,29)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499387
PNG
(4-((3-(1-(cyclopropylmethyl)- 1H-pyrazol-3- yl)phe...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ccn(CC3CC3)n2)c(F)c1
Show InChI InChI=1S/C22H22FN3O4S/c1-31(28,29)25-22(27)17-7-8-18(20(23)12-17)14-30-19-4-2-3-16(11-19)21-9-10-26(24-21)13-15-5-6-15/h2-4,7-12,15H,5-6,13-14H2,1H3,(H,25,27)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499389
PNG
(4-((3-(6-(cyclopropylmethoxy)- 2-methylpyridin-3- ...)
Show SMILES Cc1nc(OCC2CC2)ccc1-c1cccc(OCc2ccc(cc2)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C25H26N2O5S/c1-17-23(12-13-24(26-17)32-16-18-6-7-18)21-4-3-5-22(14-21)31-15-19-8-10-20(11-9-19)25(28)27-33(2,29)30/h3-5,8-14,18H,6-7,15-16H2,1-2H3,(H,27,28)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499393
PNG
(4-((3-cyano-5-(6- (cyclopropylmethoxy)pyridin-3- y...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(cc(c2)-c2ccc(OCC3CC3)nc2)C#N)cc1
Show InChI InChI=1S/C25H23N3O5S/c1-34(30,31)28-25(29)20-6-4-18(5-7-20)15-32-23-11-19(13-26)10-22(12-23)21-8-9-24(27-14-21)33-16-17-2-3-17/h4-12,14,17H,2-3,15-16H2,1H3,(H,28,29)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499395
PNG
(4-((3-(6-(cyclopropylmethoxy)- 5-methylpyridin-3- ...)
Show SMILES Cc1cc(cnc1OCC1CC1)-c1cccc(OCc2ccc(cc2F)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C25H25FN2O5S/c1-16-10-21(13-27-25(16)33-14-17-6-7-17)18-4-3-5-22(11-18)32-15-20-9-8-19(12-23(20)26)24(29)28-34(2,30)31/h3-5,8-13,17H,6-7,14-15H2,1-2H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499398
PNG
(4-((3-(6-(cyclopropylmethoxy)- 4-methylpyridin-3- ...)
Show SMILES Cc1cc(OCC2CC2)ncc1-c1cccc(OCc2ccc(cc2F)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C25H25FN2O5S/c1-16-10-24(33-14-17-6-7-17)27-13-22(16)18-4-3-5-21(11-18)32-15-20-9-8-19(12-23(20)26)25(29)28-34(2,30)31/h3-5,8-13,17H,6-7,14-15H2,1-2H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499409
PNG
(4-((3-(6-(cyclobutylmethoxy)-2- (hydroxymethyl)pyr...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ccc(OCC3CCC3)nc2CO)c(F)c1
Show InChI InChI=1S/C26H27FN2O6S/c1-36(32,33)29-26(31)19-8-9-20(23(27)13-19)16-34-21-7-3-6-18(12-21)22-10-11-25(28-24(22)14-30)35-15-17-4-2-5-17/h3,6-13,17,30H,2,4-5,14-16H2,1H3,(H,29,31)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499410
PNG
(4-((3-(6-(cyclobutylmethoxy)-2- (hydroxymethyl)pyr...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ccc(OCC3CCC3)nc2CO)cc1
Show InChI InChI=1S/C26H28N2O6S/c1-35(31,32)28-26(30)20-10-8-19(9-11-20)16-33-22-7-3-6-21(14-22)23-12-13-25(27-24(23)15-29)34-17-18-4-2-5-18/h3,6-14,18,29H,2,4-5,15-17H2,1H3,(H,28,30)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499417
PNG
(6-((3-(6- (cyclobutylmethoxy)pyridin-3- yl)phenoxy...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ccc(OCC3CCC3)nc2)nc1
Show InChI InChI=1S/C24H25N3O5S/c1-33(29,30)27-24(28)20-8-10-21(25-14-20)16-31-22-7-3-6-18(12-22)19-9-11-23(26-13-19)32-15-17-4-2-5-17/h3,6-14,17H,2,4-5,15-16H2,1H3,(H,27,28)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499421
PNG
(4-((3-(5-(cyclopropylmethoxy)- 3-fluoropyridin-2- ...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ncc(OCC3CC3)cc2F)c(F)c1
Show InChI InChI=1S/C24H22F2N2O5S/c1-34(30,31)28-24(29)17-7-8-18(21(25)10-17)14-33-19-4-2-3-16(9-19)23-22(26)11-20(12-27-23)32-13-15-5-6-15/h2-4,7-12,15H,5-6,13-14H2,1H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499429
PNG
(4-((3-(5- (cyclopropylmethoxy)pyridin-2- yl)-5-flu...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(F)cc(c2)-c2ccc(OCC3CC3)cn2)cc1
Show InChI InChI=1S/C24H23FN2O5S/c1-33(29,30)27-24(28)18-6-4-17(5-7-18)15-32-22-11-19(10-20(25)12-22)23-9-8-21(13-26-23)31-14-16-2-3-16/h4-13,16H,2-3,14-15H2,1H3,(H,27,28)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499430
PNG
(4-((3-(4-(cyclopropylmethoxy)-3- methylpyridin-2- ...)
Show SMILES Cc1c(OCC2CC2)ccnc1-c1cccc(OCc2ccc(cc2F)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C25H25FN2O5S/c1-16-23(33-14-17-6-7-17)10-11-27-24(16)18-4-3-5-21(12-18)32-15-20-9-8-19(13-22(20)26)25(29)28-34(2,30)31/h3-5,8-13,17H,6-7,14-15H2,1-2H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499436
PNG
(4-((3-(2-(cyclopropylmethoxy) pyridin-4-yl)- 5-flu...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(F)cc(c2)-c2ccnc(OCC3CC3)c2)cc1
Show InChI InChI=1S/C24H23FN2O5S/c1-33(29,30)27-24(28)18-6-4-17(5-7-18)14-31-22-11-20(10-21(25)13-22)19-8-9-26-23(12-19)32-15-16-2-3-16/h4-13,16H,2-3,14-15H2,1H3,(H,27,28)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499446
PNG
(4-((3-(6- (cyclopropylmethoxy)pyrazin-2- yl)phenox...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2cncc(OCC3CC3)n2)cc1
Show InChI InChI=1S/C23H23N3O5S/c1-32(28,29)26-23(27)18-9-7-17(8-10-18)14-30-20-4-2-3-19(11-20)21-12-24-13-22(25-21)31-15-16-5-6-16/h2-4,7-13,16H,5-6,14-15H2,1H3,(H,26,27)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499466
PNG
(4-(((3'-(cyclopropylmethoxy)- 5-fluoro-5'- (((2-hy...)
Show SMILES CN(CCO)Cc1cc(OCC2CC2)cc(c1)-c1cc(F)cc(OCc2ccc(cc2F)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C29H32F2N2O6S/c1-33(7-8-34)16-20-9-23(12-26(10-20)38-17-19-3-4-19)24-11-25(30)15-27(13-24)39-18-22-6-5-21(14-28(22)31)29(35)32-40(2,36)37/h5-6,9-15,19,34H,3-4,7-8,16-18H2,1-2H3,(H,32,35)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499314
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)phenox...)
Show SMILES FC(F)(F)S(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ccc(OCC3CC3)nc2)cc1
Show InChI InChI=1S/C24H21F3N2O5S/c25-24(26,27)35(31,32)29-23(30)18-8-6-17(7-9-18)14-33-21-3-1-2-19(12-21)20-10-11-22(28-13-20)34-15-16-4-5-16/h1-3,6-13,16H,4-5,14-15H2,(H,29,30)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499318
PNG
(4-((3-(6-(cyclopropylmethoxy)-4- methylpyridin-3- ...)
Show SMILES Cc1cc(OCC2CC2)ncc1-c1cccc(OCc2ccc(cc2)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C25H26N2O5S/c1-17-12-24(32-16-18-6-7-18)26-14-23(17)21-4-3-5-22(13-21)31-15-19-8-10-20(11-9-19)25(28)27-33(2,29)30/h3-5,8-14,18H,6-7,15-16H2,1-2H3,(H,27,28)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499325
PNG
(4-((3-(6- (cyclobutylmethoxy)pyridin-3- yl)phenoxy...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ccc(OCC3CCC3)nc2)cc1
Show InChI InChI=1S/C25H26N2O5S/c1-33(29,30)27-25(28)20-10-8-19(9-11-20)16-31-23-7-3-6-21(14-23)22-12-13-24(26-15-22)32-17-18-4-2-5-18/h3,6-15,18H,2,4-5,16-17H2,1H3,(H,27,28)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499327
PNG
(5-chloro-4-((3-(6- (cyclopropylmethoxy)pyridin-3- ...)
Show SMILES Fc1cc(COc2cccc(c2)-c2ccc(OCC3CC3)nc2)c(Cl)cc1C(=O)NS(=O)(=O)C1CC1
Show InChI InChI=1S/C26H24ClFN2O5S/c27-23-12-22(26(31)30-36(32,33)21-7-8-21)24(28)11-19(23)15-34-20-3-1-2-17(10-20)18-6-9-25(29-13-18)35-14-16-4-5-16/h1-3,6,9-13,16,21H,4-5,7-8,14-15H2,(H,30,31)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499332
PNG
(4-((4-chloro-3-(6- (cyclopropylmethoxy)pyridin-3- ...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2ccc(Cl)c(c2)-c2ccc(OCC3CC3)nc2)cc1
Show InChI InChI=1S/C24H23ClN2O5S/c1-33(29,30)27-24(28)18-6-4-17(5-7-18)14-31-20-9-10-22(25)21(12-20)19-8-11-23(26-13-19)32-15-16-2-3-16/h4-13,16H,2-3,14-15H2,1H3,(H,27,28)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499339
PNG
(N-(cyclopropylsulfonyl)-4-((3- (6-((tetrahydro-2H-...)
Show SMILES O=C(NS(=O)(=O)C1CC1)c1ccc(COc2cccc(c2)-c2ccc(OCC3CCOCC3)nc2)cc1
Show InChI InChI=1S/C28H30N2O6S/c31-28(30-37(32,33)26-9-10-26)22-6-4-20(5-7-22)18-35-25-3-1-2-23(16-25)24-8-11-27(29-17-24)36-19-21-12-14-34-15-13-21/h1-8,11,16-17,21,26H,9-10,12-15,18-19H2,(H,30,31)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499342
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)-5-flu...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(F)cc(c2)-c2ccc(OCC3CC3)nc2)c(F)c1
Show InChI InChI=1S/C24H22F2N2O5S/c1-34(30,31)28-24(29)16-4-5-18(22(26)10-16)14-32-21-9-19(8-20(25)11-21)17-6-7-23(27-12-17)33-13-15-2-3-15/h4-12,15H,2-3,13-14H2,1H3,(H,28,29)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499347
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)-5-(tr...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(cc(c2)C(F)(F)F)-c2ccc(OCC3CC3)nc2)cc1
Show InChI InChI=1S/C25H23F3N2O5S/c1-36(32,33)30-24(31)18-6-4-17(5-7-18)14-34-22-11-20(10-21(12-22)25(26,27)28)19-8-9-23(29-13-19)35-15-16-2-3-16/h4-13,16H,2-3,14-15H2,1H3,(H,30,31)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499358
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)-4-met...)
Show SMILES Cc1ccc(OCc2ccc(cc2F)C(=O)NS(=O)(=O)C2CC2)cc1-c1ccc(OCC2CC2)nc1
Show InChI InChI=1S/C27H27FN2O5S/c1-17-2-8-22(13-24(17)20-7-11-26(29-14-20)35-15-18-3-4-18)34-16-21-6-5-19(12-25(21)28)27(31)30-36(32,33)23-9-10-23/h2,5-8,11-14,18,23H,3-4,9-10,15-16H2,1H3,(H,30,31)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499364
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)phenox...)
Show SMILES Fc1cc(ccc1COc1cccc(c1)-c1ccc(OCC2CC2)nc1)C(=O)NS(=O)(=O)CC1CC1
Show InChI InChI=1S/C27H27FN2O5S/c28-25-13-21(27(31)30-36(32,33)17-19-6-7-19)8-9-23(25)16-34-24-3-1-2-20(12-24)22-10-11-26(29-14-22)35-15-18-4-5-18/h1-3,8-14,18-19H,4-7,15-17H2,(H,30,31)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499366
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)phenox...)
Show SMILES Fc1cc(ccc1COc1cccc(c1)-c1ccc(OCC2CC2)nc1)C(=O)NS(=O)(=O)c1nccs1
Show InChI InChI=1S/C26H22FN3O5S2/c27-23-13-19(25(31)30-37(32,33)26-28-10-11-36-26)6-7-21(23)16-34-22-3-1-2-18(12-22)20-8-9-24(29-14-20)35-15-17-4-5-17/h1-3,6-14,17H,4-5,15-16H2,(H,30,31)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499379
PNG
(4-((3-(5- (cyclopropylmethoxy)pyrazin-2- yl)phenox...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2cnc(OCC3CC3)cn2)c(F)c1
Show InChI InChI=1S/C23H22FN3O5S/c1-33(29,30)27-23(28)17-7-8-18(20(24)10-17)14-31-19-4-2-3-16(9-19)21-11-26-22(12-25-21)32-13-15-5-6-15/h2-4,7-12,15H,5-6,13-14H2,1H3,(H,27,28)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499392
PNG
(4-((3-fluoro-5-(6- ((tetrahydrofuran-3- yl)methoxy...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(F)cc(c2)-c2ccc(OCC3CCOC3)nc2)cc1
Show InChI InChI=1S/C25H25FN2O6S/c1-35(30,31)28-25(29)19-4-2-17(3-5-19)15-33-23-11-21(10-22(26)12-23)20-6-7-24(27-13-20)34-16-18-8-9-32-14-18/h2-7,10-13,18H,8-9,14-16H2,1H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499405
PNG
(4-((3-(6-(cyclobutylmethoxy)-5- (hydroxymethyl)pyr...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2cnc(OCC3CCC3)c(CO)c2)c(F)c1
Show InChI InChI=1S/C26H27FN2O6S/c1-36(32,33)29-25(31)19-8-9-20(24(27)12-19)16-34-23-7-3-6-18(11-23)21-10-22(14-30)26(28-13-21)35-15-17-4-2-5-17/h3,6-13,17,30H,2,4-5,14-16H2,1H3,(H,29,31)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499406
PNG
(4-((3-(6-(cyclobutylmethoxy)-5- (hydroxymethyl)pyr...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(F)cc(c2)-c2cnc(OCC3CCC3)c(CO)c2)c(F)c1
Show InChI InChI=1S/C26H26F2N2O6S/c1-37(33,34)30-25(32)17-5-6-18(24(28)10-17)15-35-23-9-19(8-22(27)11-23)20-7-21(13-31)26(29-12-20)36-14-16-3-2-4-16/h5-12,16,31H,2-4,13-15H2,1H3,(H,30,32)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499411
PNG
(4-(((5-(6- (cyclopropylmethoxy) pyridin-3-yl)- [1,...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(cc(c2)-c2ccc(OCC3CC3)nc2)-c2ccccc2)cc1
Show InChI InChI=1S/C30H28N2O5S/c1-38(34,35)32-30(33)24-11-9-22(10-12-24)19-36-28-16-26(23-5-3-2-4-6-23)15-27(17-28)25-13-14-29(31-18-25)37-20-21-7-8-21/h2-6,9-18,21H,7-8,19-20H2,1H3,(H,32,33)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499418
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-2- yl)phenox...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2cccc(OCC3CC3)n2)c(F)c1
Show InChI InChI=1S/C24H23FN2O5S/c1-33(29,30)27-24(28)18-10-11-19(21(25)13-18)15-31-20-5-2-4-17(12-20)22-6-3-7-23(26-22)32-14-16-8-9-16/h2-7,10-13,16H,8-9,14-15H2,1H3,(H,27,28)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499419
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-2- yl)-5-flu...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(F)cc(c2)-c2cccc(OCC3CC3)n2)cc1
Show InChI InChI=1S/C24H23FN2O5S/c1-33(29,30)27-24(28)18-9-7-17(8-10-18)14-31-21-12-19(11-20(25)13-21)22-3-2-4-23(26-22)32-15-16-5-6-16/h2-4,7-13,16H,5-6,14-15H2,1H3,(H,27,28)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499422
PNG
(4-((3-(5-(cyclopropylmethoxy)- 3-fluoropyridin-2-y...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(F)cc(c2)-c2ncc(OCC3CC3)cc2F)cc1
Show InChI InChI=1S/C24H22F2N2O5S/c1-34(30,31)28-24(29)17-6-4-16(5-7-17)13-32-20-9-18(8-19(25)10-20)23-22(26)11-21(12-27-23)33-14-15-2-3-15/h4-12,15H,2-3,13-14H2,1H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499437
PNG
(4-((3-(2-(cyclopropylmethoxy)-3- methylpyridin-4-y...)
Show SMILES Cc1c(OCC2CC2)nccc1-c1cccc(OCc2ccc(cc2F)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C25H25FN2O5S/c1-16-22(10-11-27-25(16)33-14-17-6-7-17)18-4-3-5-21(12-18)32-15-20-9-8-19(13-23(20)26)24(29)28-34(2,30)31/h3-5,8-13,17H,6-7,14-15H2,1-2H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499444
PNG
(4-((3-(5-(cyclobutylmethoxy) pyrazin-2-yl) phenoxy...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2cnc(OCC3CCC3)cn2)c(F)c1
Show InChI InChI=1S/C24H24FN3O5S/c1-34(30,31)28-24(29)18-8-9-19(21(25)11-18)15-32-20-7-3-6-17(10-20)22-12-27-23(13-26-22)33-14-16-4-2-5-16/h3,6-13,16H,2,4-5,14-15H2,1H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499454
PNG
(4-((3-(6-(cyclopropylmethoxy)-5- methylpyrimidin-4...)
Show SMILES Cc1c(OCC2CC2)ncnc1-c1cccc(OCc2ccc(cc2)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C24H25N3O5S/c1-16-22(25-15-26-24(16)32-14-17-6-7-17)20-4-3-5-21(12-20)31-13-18-8-10-19(11-9-18)23(28)27-33(2,29)30/h3-5,8-12,15,17H,6-7,13-14H2,1-2H3,(H,27,28)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499456
PNG
(4-((3-(2- (cyclopropylmethoxy) pyrimidin-5-yl)- 5-...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(F)cc(c2)-c2cnc(OCC3CC3)nc2)cc1
Show InChI InChI=1S/C23H22FN3O5S/c1-33(29,30)27-22(28)17-6-4-16(5-7-17)13-31-21-9-18(8-20(24)10-21)19-11-25-23(26-12-19)32-14-15-2-3-15/h4-12,15H,2-3,13-14H2,1H3,(H,27,28)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499463
PNG
(5-(cyclopropylmethoxy)- 3'-fluoro- 5'-((2-fluoro-4...)
Show SMILES CN(C)C(=O)c1cc(OCC2CC2)cc(c1)-c1cc(F)cc(OCc2ccc(cc2F)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C28H28F2N2O6S/c1-32(2)28(34)22-8-20(10-24(12-22)37-15-17-4-5-17)21-9-23(29)14-25(11-21)38-16-19-7-6-18(13-26(19)30)27(33)31-39(3,35)36/h6-14,17H,4-5,15-16H2,1-3H3,(H,31,33)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499464
PNG
(4-(((3'-(cyclopropylmethoxy)- 5'-(2- (dimethylamin...)
Show SMILES CN(C)C(=O)COc1cc(OCC2CC2)cc(c1)-c1cc(F)cc(OCc2ccc(cc2F)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C29H30F2N2O7S/c1-33(2)28(34)17-40-26-11-22(10-25(14-26)38-15-18-4-5-18)21-8-23(30)13-24(9-21)39-16-20-7-6-19(12-27(20)31)29(35)32-41(3,36)37/h6-14,18H,4-5,15-17H2,1-3H3,(H,32,35)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499469
PNG
(4-((3-(6-(cyclopropyl- methoxy)pyridin- 3-yl)-5-fl...)
Show SMILES CC(C)S(=O)(=O)NC(=O)c1ccc(COc2cc(F)cc(c2)-c2ccc(OCC3CC3)nc2)cc1
Show InChI InChI=1S/C26H27FN2O5S/c1-17(2)35(31,32)29-26(30)20-7-5-19(6-8-20)15-33-24-12-22(11-23(27)13-24)21-9-10-25(28-14-21)34-16-18-3-4-18/h5-14,17-18H,3-4,15-16H2,1-2H3,(H,29,30)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499324
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)phenox...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ccc(OCC3CC3)nc2)c(F)c1
Show InChI InChI=1S/C24H23FN2O5S/c1-33(29,30)27-24(28)18-7-8-20(22(25)12-18)15-31-21-4-2-3-17(11-21)19-9-10-23(26-13-19)32-14-16-5-6-16/h2-4,7-13,16H,5-6,14-15H2,1H3,(H,27,28)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499326
PNG
(5-chloro-4-((3-(6- (cyclopropylmethoxy)pyridin-3- ...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(COc2cccc(c2)-c2ccc(OCC3CC3)nc2)cc1F
Show InChI InChI=1S/C24H22ClFN2O5S/c1-34(30,31)28-24(29)20-11-21(25)18(10-22(20)26)14-32-19-4-2-3-16(9-19)17-7-8-23(27-12-17)33-13-15-5-6-15/h2-4,7-12,15H,5-6,13-14H2,1H3,(H,28,29)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499333
PNG
(5-cyclopropyl-4-((3-(6- (cyclopropylmethoxy)pyridi...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(COc2cccc(c2)-c2ccc(OCC3CC3)nc2)cc1F
Show InChI InChI=1S/C27H27FN2O5S/c1-36(32,33)30-27(31)24-13-23(18-7-8-18)21(12-25(24)28)16-34-22-4-2-3-19(11-22)20-9-10-26(29-14-20)35-15-17-5-6-17/h2-4,9-14,17-18H,5-8,15-16H2,1H3,(H,30,31)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499336
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)phenox...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(OC(F)F)c(COc2cccc(c2)-c2ccc(OCC3CC3)nc2)cc1F
Show InChI InChI=1S/C25H23F3N2O6S/c1-37(32,33)30-24(31)20-11-22(36-25(27)28)18(10-21(20)26)14-34-19-4-2-3-16(9-19)17-7-8-23(29-12-17)35-13-15-5-6-15/h2-4,7-12,15,25H,5-6,13-14H2,1H3,(H,30,31)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499337
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)phenox...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ccc(OCC3CC3)nc2)cc1F
Show InChI InChI=1S/C24H23FN2O5S/c1-33(29,30)27-24(28)21-9-7-17(11-22(21)25)15-31-20-4-2-3-18(12-20)19-8-10-23(26-13-19)32-14-16-5-6-16/h2-4,7-13,16H,5-6,14-15H2,1H3,(H,27,28)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499345
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)-5-met...)
Show SMILES Cc1cc(OCc2ccc(cc2F)C(=O)NS(C)(=O)=O)cc(c1)-c1ccc(OCC2CC2)nc1
Show InChI InChI=1S/C25H25FN2O5S/c1-16-9-21(19-7-8-24(27-13-19)33-14-17-3-4-17)11-22(10-16)32-15-20-6-5-18(12-23(20)26)25(29)28-34(2,30)31/h5-13,17H,3-4,14-15H2,1-2H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499350
PNG
(3-cyano-4-((3-(6- (cyclopropylmethoxy)pyridin-3- y...)
Show SMILES O=C(NS(=O)(=O)C1CC1)c1ccc(COc2cccc(c2)-c2ccc(OCC3CC3)nc2)c(c1)C#N
Show InChI InChI=1S/C27H25N3O5S/c28-14-23-12-20(27(31)30-36(32,33)25-9-10-25)6-7-22(23)17-34-24-3-1-2-19(13-24)21-8-11-26(29-15-21)35-16-18-4-5-18/h1-3,6-8,11-13,15,18,25H,4-5,9-10,16-17H2,(H,30,31)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499357
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)-4-met...)
Show SMILES Cc1ccc(OCc2ccc(cc2F)C(=O)NS(C)(=O)=O)cc1-c1ccc(OCC2CC2)nc1
Show InChI InChI=1S/C25H25FN2O5S/c1-16-3-9-21(12-22(16)19-8-10-24(27-13-19)33-14-17-4-5-17)32-15-20-7-6-18(11-23(20)26)25(29)28-34(2,30)31/h3,6-13,17H,4-5,14-15H2,1-2H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499363
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)phenox...)
Show SMILES Fc1cc(ccc1COc1cccc(c1)-c1ccc(OCC2CC2)nc1)C(=O)NS(=O)(=O)C1CC1
Show InChI InChI=1S/C26H25FN2O5S/c27-24-13-19(26(30)29-35(31,32)23-9-10-23)6-7-21(24)16-33-22-3-1-2-18(12-22)20-8-11-25(28-14-20)34-15-17-4-5-17/h1-3,6-8,11-14,17,23H,4-5,9-10,15-16H2,(H,29,30)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499374
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-2- yl)phenox...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2cccc(OCC3CC3)n2)cc1
Show InChI InChI=1S/C24H24N2O5S/c1-32(28,29)26-24(27)19-12-10-18(11-13-19)15-30-21-5-2-4-20(14-21)22-6-3-7-23(25-22)31-16-17-8-9-17/h2-7,10-14,17H,8-9,15-16H2,1H3,(H,26,27)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499375
PNG
(4-((3-(3-chloro-5- (cyclopropylmethoxy)pyridin-2- ...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ncc(OCC3CC3)cc2Cl)cc1
Show InChI InChI=1S/C24H23ClN2O5S/c1-33(29,30)27-24(28)18-9-7-17(8-10-18)14-31-20-4-2-3-19(11-20)23-22(25)12-21(13-26-23)32-15-16-5-6-16/h2-4,7-13,16H,5-6,14-15H2,1H3,(H,27,28)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499381
PNG
(4-((3-(6- (cyclopropylmethoxy)pyrazin-2- yl)phenox...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2cncc(OCC3CC3)n2)c(F)c1
Show InChI InChI=1S/C23H22FN3O5S/c1-33(29,30)27-23(28)17-7-8-18(20(24)10-17)14-31-19-4-2-3-16(9-19)21-11-25-12-22(26-21)32-13-15-5-6-15/h2-4,7-12,15H,5-6,13-14H2,1H3,(H,27,28)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499397
PNG
(4-((3-(6-(cyclopropylmethoxy)- 2-methylpyridin-3-y...)
Show SMILES Cc1nc(OCC2CC2)ccc1-c1cc(F)cc(OCc2ccc(cc2)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C25H25FN2O5S/c1-16-23(9-10-24(27-16)33-15-17-3-4-17)20-11-21(26)13-22(12-20)32-14-18-5-7-19(8-6-18)25(29)28-34(2,30)31/h5-13,17H,3-4,14-15H2,1-2H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499413
PNG
(4-((3-(6- (cyclopropylmethoxy) pyridin-3-yl)- 5-(1...)
Show SMILES Cn1cc(cn1)-c1cc(OCc2ccc(cc2)C(=O)NS(C)(=O)=O)cc(c1)-c1ccc(OCC2CC2)nc1
Show InChI InChI=1S/C28H28N4O5S/c1-32-16-25(15-30-32)24-11-23(22-9-10-27(29-14-22)37-18-19-3-4-19)12-26(13-24)36-17-20-5-7-21(8-6-20)28(33)31-38(2,34)35/h5-16,19H,3-4,17-18H2,1-2H3,(H,31,33)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499432
PNG
(4-((3-(4- (cyclopropylmethoxy)pyridin-2- yl)-5-flu...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(F)cc(c2)-c2cc(OCC3CC3)ccn2)cc1
Show InChI InChI=1S/C24H23FN2O5S/c1-33(29,30)27-24(28)18-6-4-17(5-7-18)15-32-22-11-19(10-20(25)12-22)23-13-21(8-9-26-23)31-14-16-2-3-16/h4-13,16H,2-3,14-15H2,1H3,(H,27,28)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499447
PNG
(4-((3-(5- (cyclopropylmethoxy)pyrimidin-2- yl)-5-f...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(F)cc(c2)-c2ncc(OCC3CC3)cn2)cc1
Show InChI InChI=1S/C23H22FN3O5S/c1-33(29,30)27-23(28)17-6-4-16(5-7-17)13-31-20-9-18(8-19(24)10-20)22-25-11-21(12-26-22)32-14-15-2-3-15/h4-12,15H,2-3,13-14H2,1H3,(H,27,28)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499451
PNG
(4-((3-(6- (cyclopropylmethoxy)pyrimidin- 4-yl)phen...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2cc(OCC3CC3)ncn2)c(F)c1
Show InChI InChI=1S/C23H22FN3O5S/c1-33(29,30)27-23(28)17-7-8-18(20(24)10-17)13-31-19-4-2-3-16(9-19)21-11-22(26-14-25-21)32-12-15-5-6-15/h2-4,7-11,14-15H,5-6,12-13H2,1H3,(H,27,28)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499462
PNG
(4-(((3'-(cyclopropylmethoxy)- 5-fluoro- 5'-(morpho...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(F)cc(c2)-c2cc(OCC3CC3)cc(c2)C(=O)N2CCOCC2)c(F)c1
Show InChI InChI=1S/C30H30F2N2O7S/c1-42(37,38)33-29(35)20-4-5-21(28(32)15-20)18-41-27-13-23(11-25(31)16-27)22-10-24(30(36)34-6-8-39-9-7-34)14-26(12-22)40-17-19-2-3-19/h4-5,10-16,19H,2-3,6-9,17-18H2,1H3,(H,33,35)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499465
PNG
(4-(((3'-(cyclopropylmethoxy)- 5-fluoro-5'- (3-meth...)
Show SMILES COC1CN(C1)C(=O)c1cc(OCC2CC2)cc(c1)-c1cc(F)cc(OCc2ccc(cc2F)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C30H30F2N2O7S/c1-39-27-14-34(15-27)30(36)23-7-21(9-25(11-23)40-16-18-3-4-18)22-8-24(31)13-26(10-22)41-17-20-6-5-19(12-28(20)32)29(35)33-42(2,37)38/h5-13,18,27H,3-4,14-17H2,1-2H3,(H,33,35)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499471
PNG
(4-((3-(6-(cyclopropyl- methoxy)pyridin- 3-yl)-5-fl...)
Show SMILES Fc1cc(OCc2ccc(cc2)C(=O)NS(=O)(=O)CC2CC2)cc(c1)-c1ccc(OCC2CC2)nc1
Show InChI InChI=1S/C27H27FN2O5S/c28-24-11-23(22-9-10-26(29-14-22)35-16-18-1-2-18)12-25(13-24)34-15-19-5-7-21(8-6-19)27(31)30-36(32,33)17-20-3-4-20/h5-14,18,20H,1-4,15-17H2,(H,30,31)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499316
PNG
(4-((3-(6-((3,3- difluorocyclobutyl)methoxy) pyridi...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ccc(OCC3CC(F)(F)C3)nc2)cc1
Show InChI InChI=1S/C25H24F2N2O5S/c1-35(31,32)29-24(30)19-7-5-17(6-8-19)15-33-22-4-2-3-20(11-22)21-9-10-23(28-14-21)34-16-18-12-25(26,27)13-18/h2-11,14,18H,12-13,15-16H2,1H3,(H,29,30)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499320
PNG
(4-((3-(6-(cyclopropylmethoxy)- 5-methylpyridin-3- ...)
Show SMILES Cc1cc(cnc1OCC1CC1)-c1cccc(OCc2ccc(cc2)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C25H26N2O5S/c1-17-12-22(14-26-25(17)32-16-18-6-7-18)21-4-3-5-23(13-21)31-15-19-8-10-20(11-9-19)24(28)27-33(2,29)30/h3-5,8-14,18H,6-7,15-16H2,1-2H3,(H,27,28)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499321
PNG
(US11020381, Example 11 | tert-butyl 4-(((5-(3-((4-...)
Show SMILES CC(C)(C)OC(=O)N1CCC(COc2ccc(cn2)-c2cccc(OCc3ccc(cc3)C(=O)NS(C)(=O)=O)c2)CC1
Show InChI InChI=1S/C31H37N3O7S/c1-31(2,3)41-30(36)34-16-14-23(15-17-34)21-40-28-13-12-26(19-32-28)25-6-5-7-27(18-25)39-20-22-8-10-24(11-9-22)29(35)33-42(4,37)38/h5-13,18-19,23H,14-17,20-21H2,1-4H3,(H,33,35)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499323
PNG
(3-chloro-4-((3-(6- (cyclopropylmethoxy)pyridin-3- ...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ccc(OCC3CC3)nc2)c(Cl)c1
Show InChI InChI=1S/C24H23ClN2O5S/c1-33(29,30)27-24(28)18-7-8-20(22(25)12-18)15-31-21-4-2-3-17(11-21)19-9-10-23(26-13-19)32-14-16-5-6-16/h2-4,7-13,16H,5-6,14-15H2,1H3,(H,27,28)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499329
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)phenox...)
Show SMILES O=C(NS(=O)(=O)c1nccs1)c1ccc(COc2cccc(c2)-c2ccc(OCC3CC3)nc2)cc1
Show InChI InChI=1S/C26H23N3O5S2/c30-25(29-36(31,32)26-27-12-13-35-26)20-8-6-19(7-9-20)16-33-23-3-1-2-21(14-23)22-10-11-24(28-15-22)34-17-18-4-5-18/h1-3,6-15,18H,4-5,16-17H2,(H,29,30)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499334
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)phenox...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(F)c(COc2cccc(c2)-c2ccc(OCC3CC3)nc2)cc1F
Show InChI InChI=1S/C24H22F2N2O5S/c1-34(30,31)28-24(29)20-11-21(25)18(10-22(20)26)14-32-19-4-2-3-16(9-19)17-7-8-23(27-12-17)33-13-15-5-6-15/h2-4,7-12,15H,5-6,13-14H2,1H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499338
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)phenox...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(F)c(COc2cccc(c2)-c2ccc(OCC3CC3)nc2)c(F)c1
Show InChI InChI=1S/C24H22F2N2O5S/c1-34(30,31)28-24(29)18-10-21(25)20(22(26)11-18)14-32-19-4-2-3-16(9-19)17-7-8-23(27-12-17)33-13-15-5-6-15/h2-4,7-12,15H,5-6,13-14H2,1H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499359
PNG
(4-((4-chloro-3-(6- (cyclopropylmethoxy)pyridin-3- ...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2ccc(Cl)c(c2)-c2ccc(OCC3CC3)nc2)c(F)c1
Show InChI InChI=1S/C24H22ClFN2O5S/c1-34(30,31)28-24(29)16-4-5-18(22(26)10-16)14-32-19-7-8-21(25)20(11-19)17-6-9-23(27-12-17)33-13-15-2-3-15/h4-12,15H,2-3,13-14H2,1H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499361
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)phenox...)
Show SMILES CCS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ccc(OCC3CC3)nc2)c(F)c1
Show InChI InChI=1S/C25H25FN2O5S/c1-2-34(30,31)28-25(29)19-8-9-21(23(26)13-19)16-32-22-5-3-4-18(12-22)20-10-11-24(27-14-20)33-15-17-6-7-17/h3-5,8-14,17H,2,6-7,15-16H2,1H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499377
PNG
(4-((3-(2- (cyclopropylmethoxy)pyridin-4- yl)phenox...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ccnc(OCC3CC3)c2)cc1
Show InChI InChI=1S/C24H24N2O5S/c1-32(28,29)26-24(27)19-9-7-18(8-10-19)15-30-22-4-2-3-20(13-22)21-11-12-25-23(14-21)31-16-17-5-6-17/h2-4,7-14,17H,5-6,15-16H2,1H3,(H,26,27)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499382
PNG
(4-((3-(5- (cyclopropylmethoxy)pyrimidin- 2-yl)phen...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ncc(OCC3CC3)cn2)c(F)c1
Show InChI InChI=1S/C23H22FN3O5S/c1-33(29,30)27-23(28)17-7-8-18(21(24)10-17)14-32-19-4-2-3-16(9-19)22-25-11-20(12-26-22)31-13-15-5-6-15/h2-4,7-12,15H,5-6,13-14H2,1H3,(H,27,28)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499400
PNG
(4-((3-(5-chloro-6- (cyclopropylmethoxy)pyridin-3- ...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2cnc(OCC3CC3)c(Cl)c2)c(F)c1
Show InChI InChI=1S/C24H22ClFN2O5S/c1-34(30,31)28-23(29)17-7-8-18(22(26)11-17)14-32-20-4-2-3-16(9-20)19-10-21(25)24(27-12-19)33-13-15-5-6-15/h2-4,7-12,15H,5-6,13-14H2,1H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499401
PNG
(US11020381, Example 97 | tert-butyl 3-(((5-(3-((2-...)
Show SMILES CC(C)(C)OC(=O)N1CC(COc2ccc(cn2)-c2cccc(OCc3ccc(cc3F)C(=O)NS(C)(=O)=O)c2)C1
Show InChI InChI=1S/C29H32FN3O7S/c1-29(2,3)40-28(35)33-15-19(16-33)17-39-26-11-10-22(14-31-26)20-6-5-7-24(12-20)38-18-23-9-8-21(13-25(23)30)27(34)32-41(4,36)37/h5-14,19H,15-18H2,1-4H3,(H,32,34)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499404
PNG
(4-((3-(6-(cyclopropylmethoxy)-2- methylpyridin-3-y...)
Show SMILES Cc1nc(OCC2CC2)ccc1-c1cc(OCc2ccc(cc2F)C(=O)NS(C)(=O)=O)ccc1F
Show InChI InChI=1S/C25H24F2N2O5S/c1-15-20(8-10-24(28-15)34-13-16-3-4-16)21-12-19(7-9-22(21)26)33-14-18-6-5-17(11-23(18)27)25(30)29-35(2,31)32/h5-12,16H,3-4,13-14H2,1-2H3,(H,29,30)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499407
PNG
(4-((3-(6-(cyclobutylmethoxy)-5- (hydroxymethyl)pyr...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2cnc(OCC3CCC3)c(CO)c2)cc1
Show InChI InChI=1S/C26H28N2O6S/c1-35(31,32)28-25(30)20-10-8-19(9-11-20)16-33-24-7-3-6-21(13-24)22-12-23(15-29)26(27-14-22)34-17-18-4-2-5-18/h3,6-14,18,29H,2,4-5,15-17H2,1H3,(H,28,30)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499414
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)-5-(py...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(cc(c2)-c2ccc(OCC3CC3)nc2)-c2cccnc2)cc1
Show InChI InChI=1S/C29H27N3O5S/c1-38(34,35)32-29(33)22-8-6-21(7-9-22)18-36-27-14-25(23-3-2-12-30-16-23)13-26(15-27)24-10-11-28(31-17-24)37-19-20-4-5-20/h2-3,6-17,20H,4-5,18-19H2,1H3,(H,32,33)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499424
PNG
(4-((3-(5-(cyclopropylmethoxy)-3- methylpyridin-2- ...)
Show SMILES Cc1cc(OCC2CC2)cnc1-c1cccc(OCc2ccc(cc2F)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C25H25FN2O5S/c1-16-10-22(32-14-17-6-7-17)13-27-24(16)18-4-3-5-21(11-18)33-15-20-9-8-19(12-23(20)26)25(29)28-34(2,30)31/h3-5,8-13,17H,6-7,14-15H2,1-2H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499431
PNG
(4-((3-(4-(cyclopropylmethoxy)-3- methylpyridin-2-y...)
Show SMILES Cc1c(OCC2CC2)ccnc1-c1cc(F)cc(OCc2ccc(cc2)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C25H25FN2O5S/c1-16-23(33-15-17-3-4-17)9-10-27-24(16)20-11-21(26)13-22(12-20)32-14-18-5-7-19(8-6-18)25(29)28-34(2,30)31/h5-13,17H,3-4,14-15H2,1-2H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499433
PNG
(4-((3-(4- (cyclopropylmethoxy)pyridin-2- yl)phenox...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2cc(OCC3CC3)ccn2)cc1
Show InChI InChI=1S/C24H24N2O5S/c1-32(28,29)26-24(27)19-9-7-18(8-10-19)16-30-21-4-2-3-20(13-21)23-14-22(11-12-25-23)31-15-17-5-6-17/h2-4,7-14,17H,5-6,15-16H2,1H3,(H,26,27)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499434
PNG
(4-((3-(4- (cyclopropylmethoxy)pyridin-2- yl)phenox...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2cc(OCC3CC3)ccn2)c(F)c1
Show InChI InChI=1S/C24H23FN2O5S/c1-33(29,30)27-24(28)18-7-8-19(22(25)12-18)15-32-20-4-2-3-17(11-20)23-13-21(9-10-26-23)31-14-16-5-6-16/h2-4,7-13,16H,5-6,14-15H2,1H3,(H,27,28)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499442
PNG
(4-((3-(5-(cyclopropylmethoxy) pyrazin-2-yl)- 5-flu...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(F)cc(c2)-c2cnc(OCC3CC3)cn2)cc1
Show InChI InChI=1S/C23H22FN3O5S/c1-33(29,30)27-23(28)17-6-4-16(5-7-17)13-31-20-9-18(8-19(24)10-20)21-11-26-22(12-25-21)32-14-15-2-3-15/h4-12,15H,2-3,13-14H2,1H3,(H,27,28)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499467
PNG
(US11020381, Example 170 | ethyl 4-(((5-(3-((4- ((m...)
Show SMILES CCOC(=O)N1CCC(COc2ccc(cn2)-c2cccc(OCc3ccc(cc3)C(=O)NS(C)(=O)=O)c2)CC1
Show InChI InChI=1S/C29H33N3O7S/c1-3-37-29(34)32-15-13-22(14-16-32)20-39-27-12-11-25(18-30-27)24-5-4-6-26(17-24)38-19-21-7-9-23(10-8-21)28(33)31-40(2,35)36/h4-12,17-18,22H,3,13-16,19-20H2,1-2H3,(H,31,33)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499328
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)phenox...)
Show SMILES O=C(NS(=O)(=O)c1cccs1)c1ccc(COc2cccc(c2)-c2ccc(OCC3CC3)nc2)cc1
Show InChI InChI=1S/C27H24N2O5S2/c30-27(29-36(31,32)26-5-2-14-35-26)21-10-8-20(9-11-21)17-33-24-4-1-3-22(15-24)23-12-13-25(28-16-23)34-18-19-6-7-19/h1-5,8-16,19H,6-7,17-18H2,(H,29,30)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499351
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)-4-flu...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2ccc(F)c(c2)-c2ccc(OCC3CC3)nc2)cc1
Show InChI InChI=1S/C24H23FN2O5S/c1-33(29,30)27-24(28)18-6-4-17(5-7-18)14-31-20-9-10-22(25)21(12-20)19-8-11-23(26-13-19)32-15-16-2-3-16/h4-13,16H,2-3,14-15H2,1H3,(H,27,28)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499367
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)phenox...)
Show SMILES COc1cc(ccc1COc1cccc(c1)-c1ccc(OCC2CC2)nc1)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C25H26N2O6S/c1-31-23-13-19(25(28)27-34(2,29)30)8-9-21(23)16-32-22-5-3-4-18(12-22)20-10-11-24(26-14-20)33-15-17-6-7-17/h3-5,8-14,17H,6-7,15-16H2,1-2H3,(H,27,28)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499373
PNG
(4-(((6'-(cyclopropylmethoxy)- [2,3'-bipyridin]-6-y...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(n2)-c2ccc(OCC3CC3)nc2)cc1
Show InChI InChI=1S/C23H23N3O5S/c1-32(28,29)26-23(27)18-9-7-17(8-10-18)15-31-22-4-2-3-20(25-22)19-11-12-21(24-13-19)30-14-16-5-6-16/h2-4,7-13,16H,5-6,14-15H2,1H3,(H,26,27)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499376
PNG
(4-((3-(5-(cyclopropylmethoxy)-3- fluoropyridin-2- ...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ncc(OCC3CC3)cc2F)cc1
Show InChI InChI=1S/C24H23FN2O5S/c1-33(29,30)27-24(28)18-9-7-17(8-10-18)14-31-20-4-2-3-19(11-20)23-22(25)12-21(13-26-23)32-15-16-5-6-16/h2-4,7-13,16H,5-6,14-15H2,1H3,(H,27,28)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499403
PNG
(4-((3-(5-chloro-6- (cyclopropylmethoxy)pyridin-3- ...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2ccc(F)c(c2)-c2cnc(OCC3CC3)c(Cl)c2)c(F)c1
Show InChI InChI=1S/C24H21ClF2N2O5S/c1-35(31,32)29-23(30)15-4-5-16(22(27)9-15)13-33-18-6-7-21(26)19(10-18)17-8-20(25)24(28-11-17)34-12-14-2-3-14/h4-11,14H,2-3,12-13H2,1H3,(H,29,30)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499448
PNG
(4-((3-(5- (cyclobutylmethoxy)pyrimidin-2- yl)-5-fl...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(F)cc(c2)-c2ncc(OCC3CCC3)cn2)cc1
Show InChI InChI=1S/C24H24FN3O5S/c1-34(30,31)28-24(29)18-7-5-17(6-8-18)15-32-21-10-19(9-20(25)11-21)23-26-12-22(13-27-23)33-14-16-3-2-4-16/h5-13,16H,2-4,14-15H2,1H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499457
PNG
(4-((3-(2-(cyclopropylmethoxy)-4- methylpyrimidin-5...)
Show SMILES Cc1nc(OCC2CC2)ncc1-c1cccc(OCc2ccc(cc2F)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C24H24FN3O5S/c1-15-21(12-26-24(27-15)33-13-16-6-7-16)17-4-3-5-20(10-17)32-14-19-9-8-18(11-22(19)25)23(29)28-34(2,30)31/h3-5,8-12,16H,6-7,13-14H2,1-2H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499459
PNG
(4-(((3'-(2-amino-2-oxoethoxy)-5'- (cyclopropylmeth...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(F)cc(c2)-c2cc(OCC3CC3)cc(OCC(N)=O)c2)c(F)c1
Show InChI InChI=1S/C27H26F2N2O7S/c1-39(34,35)31-27(33)17-4-5-18(25(29)10-17)14-37-22-7-19(6-21(28)11-22)20-8-23(36-13-16-2-3-16)12-24(9-20)38-15-26(30)32/h4-12,16H,2-3,13-15H2,1H3,(H2,30,32)(H,31,33)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499460
PNG
(4-(((3'-(cyclopropylmethoxy)- 5-fluoro- 5'-(2-meth...)
Show SMILES COCCOc1cc(OCC2CC2)cc(c1)-c1cc(F)cc(OCc2ccc(cc2F)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C28H29F2NO7S/c1-35-7-8-36-25-11-22(12-26(15-25)37-16-18-3-4-18)21-9-23(29)14-24(10-21)38-17-20-6-5-19(13-27(20)30)28(32)31-39(2,33)34/h5-6,9-15,18H,3-4,7-8,16-17H2,1-2H3,(H,31,32)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499461
PNG
(4-(((3'-(cyclopropylmethoxy)- 5-fluoro- 5'-(2-hydr...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(F)cc(c2)-c2cc(OCCO)cc(OCC3CC3)c2)c(F)c1
Show InChI InChI=1S/C27H27F2NO7S/c1-38(33,34)30-27(32)18-4-5-19(26(29)12-18)16-37-23-9-20(8-22(28)13-23)21-10-24(35-7-6-31)14-25(11-21)36-15-17-2-3-17/h4-5,8-14,17,31H,2-3,6-7,15-16H2,1H3,(H,30,32)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499468
PNG
(4-((3-(6-(cyclopropyl- methoxy)pyridin- 3-yl)-5-fl...)
Show SMILES CCS(=O)(=O)NC(=O)c1ccc(COc2cc(F)cc(c2)-c2ccc(OCC3CC3)nc2)cc1
Show InChI InChI=1S/C25H25FN2O5S/c1-2-34(30,31)28-25(29)19-7-5-18(6-8-19)15-32-23-12-21(11-22(26)13-23)20-9-10-24(27-14-20)33-16-17-3-4-17/h5-14,17H,2-4,15-16H2,1H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499473
PNG
(4-((3-(6-(cyclopropyl- methoxy)pyridin- 3-yl)-5-fl...)
Show SMILES Fc1cc(OCc2ccc(cc2)C(=O)NS(=O)(=O)C(F)(F)F)cc(c1)-c1ccc(OCC2CC2)nc1
Show InChI InChI=1S/C24H20F4N2O5S/c25-20-9-19(18-7-8-22(29-12-18)35-14-15-1-2-15)10-21(11-20)34-13-16-3-5-17(6-4-16)23(31)30-36(32,33)24(26,27)28/h3-12,15H,1-2,13-14H2,(H,30,31)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499317
PNG
(4-((3-(6-((4,4- difluorocyclohexyl)methoxy) pyridi...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ccc(OCC3CCC(F)(F)CC3)nc2)cc1
Show InChI InChI=1S/C27H28F2N2O5S/c1-37(33,34)31-26(32)21-7-5-19(6-8-21)17-35-24-4-2-3-22(15-24)23-9-10-25(30-16-23)36-18-20-11-13-27(28,29)14-12-20/h2-10,15-16,20H,11-14,17-18H2,1H3,(H,31,32)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499319
PNG
(4-((3-(6- (cyclopentylmethoxy)pyridin-3- yl)phenox...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ccc(OCC3CCCC3)nc2)cc1
Show InChI InChI=1S/C26H28N2O5S/c1-34(30,31)28-26(29)21-11-9-20(10-12-21)17-32-24-8-4-7-22(15-24)23-13-14-25(27-16-23)33-18-19-5-2-3-6-19/h4,7-16,19H,2-3,5-6,17-18H2,1H3,(H,28,29)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499331
PNG
(4-((3-chloro-5-(6- (cyclopropylmethoxy)pyridin-3- ...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(Cl)cc(c2)-c2ccc(OCC3CC3)nc2)cc1
Show InChI InChI=1S/C24H23ClN2O5S/c1-33(29,30)27-24(28)18-6-4-17(5-7-18)14-31-22-11-20(10-21(25)12-22)19-8-9-23(26-13-19)32-15-16-2-3-16/h4-13,16H,2-3,14-15H2,1H3,(H,27,28)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499340
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)-5-flu...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(F)cc(c2)-c2ccc(OCC3CC3)nc2)cc1
Show InChI InChI=1S/C24H23FN2O5S/c1-33(29,30)27-24(28)18-6-4-17(5-7-18)14-31-22-11-20(10-21(25)12-22)19-8-9-23(26-13-19)32-15-16-2-3-16/h4-13,16H,2-3,14-15H2,1H3,(H,27,28)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499346
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)-5-met...)
Show SMILES Cc1cc(OCc2ccc(cc2F)C(=O)NS(=O)(=O)C2CC2)cc(c1)-c1ccc(OCC2CC2)nc1
Show InChI InChI=1S/C27H27FN2O5S/c1-17-10-22(20-6-9-26(29-14-20)35-15-18-2-3-18)12-23(11-17)34-16-21-5-4-19(13-25(21)28)27(31)30-36(32,33)24-7-8-24/h4-6,9-14,18,24H,2-3,7-8,15-16H2,1H3,(H,30,31)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499353
PNG
(4-((5-(6- (cyclopropylmethoxy)pyridin-3- yl)-2-flu...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(ccc2F)-c2ccc(OCC3CC3)nc2)cc1
Show InChI InChI=1S/C24H23FN2O5S/c1-33(29,30)27-24(28)18-6-4-17(5-7-18)14-31-22-12-19(8-10-21(22)25)20-9-11-23(26-13-20)32-15-16-2-3-16/h4-13,16H,2-3,14-15H2,1H3,(H,27,28)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499371
PNG
(6-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)-5-flu...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(F)cc(c2)-c2ccc(OCC3CC3)nc2)nc1
Show InChI InChI=1S/C23H22FN3O5S/c1-33(29,30)27-23(28)17-4-6-20(25-12-17)14-31-21-9-18(8-19(24)10-21)16-5-7-22(26-11-16)32-13-15-2-3-15/h4-12,15H,2-3,13-14H2,1H3,(H,27,28)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499380
PNG
(4-((3-(5- (cyclopropylmethoxy)pyrazin-2- yl)phenox...)
Show SMILES O=C(NS(=O)(=O)C1CC1)c1ccc(COc2cccc(c2)-c2cnc(OCC3CC3)cn2)cc1
Show InChI InChI=1S/C25H25N3O5S/c29-25(28-34(30,31)22-10-11-22)19-8-6-18(7-9-19)15-32-21-3-1-2-20(12-21)23-13-27-24(14-26-23)33-16-17-4-5-17/h1-3,6-9,12-14,17,22H,4-5,10-11,15-16H2,(H,28,29)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499388
PNG
(4-((3-(5- (cyclopropylmethyl)isoxazol-3- yl)phenox...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2cc(CC3CC3)on2)c(F)c1
Show InChI InChI=1S/C22H21FN2O5S/c1-31(27,28)25-22(26)16-7-8-17(20(23)11-16)13-29-18-4-2-3-15(10-18)21-12-19(30-24-21)9-14-5-6-14/h2-4,7-8,10-12,14H,5-6,9,13H2,1H3,(H,25,26)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499391
PNG
(3-fluoro-N-(methylsulfonyl)-4- ((3-(6-((tetrahydro...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ccc(OCC3CCOC3)nc2)c(F)c1
Show InChI InChI=1S/C25H25FN2O6S/c1-35(30,31)28-25(29)19-5-6-21(23(26)12-19)16-33-22-4-2-3-18(11-22)20-7-8-24(27-13-20)34-15-17-9-10-32-14-17/h2-8,11-13,17H,9-10,14-16H2,1H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499408
PNG
(4-((3-(6-(cyclobutylmethoxy)-5- (hydroxymethyl)pyr...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(F)cc(c2)-c2cnc(OCC3CCC3)c(CO)c2)cc1
Show InChI InChI=1S/C26H27FN2O6S/c1-36(32,33)29-25(31)19-7-5-18(6-8-19)15-34-24-11-20(10-23(27)12-24)21-9-22(14-30)26(28-13-21)35-16-17-3-2-4-17/h5-13,17,30H,2-4,14-16H2,1H3,(H,29,31)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499415
PNG
(4-((3-(5- (cyclopropylmethoxy)pyridin-3- yl)phenox...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2cncc(OCC3CC3)c2)c(F)c1
Show InChI InChI=1S/C24H23FN2O5S/c1-33(29,30)27-24(28)18-7-8-19(23(25)11-18)15-32-21-4-2-3-17(9-21)20-10-22(13-26-12-20)31-14-16-5-6-16/h2-4,7-13,16H,5-6,14-15H2,1H3,(H,27,28)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499420
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-2- yl)-4-flu...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2ccc(F)c(c2)-c2cccc(OCC3CC3)n2)c(F)c1
Show InChI InChI=1S/C24H22F2N2O5S/c1-34(30,31)28-24(29)16-7-8-17(21(26)11-16)14-32-18-9-10-20(25)19(12-18)22-3-2-4-23(27-22)33-13-15-5-6-15/h2-4,7-12,15H,5-6,13-14H2,1H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499435
PNG
(4-((3-(2-(cyclopropylmethoxy) pyridin-4-yl) phenox...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ccnc(OCC3CC3)c2)c(F)c1
Show InChI InChI=1S/C24H23FN2O5S/c1-33(29,30)27-24(28)19-7-8-20(22(25)12-19)15-31-21-4-2-3-17(11-21)18-9-10-26-23(13-18)32-14-16-5-6-16/h2-4,7-13,16H,5-6,14-15H2,1H3,(H,27,28)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499438
PNG
(4-((3-(2-(cyclopropylmethoxy)-3- methylpyridin-4-y...)
Show SMILES Cc1c(OCC2CC2)nccc1-c1cc(F)cc(OCc2ccc(cc2)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C25H25FN2O5S/c1-16-23(9-10-27-25(16)33-15-17-3-4-17)20-11-21(26)13-22(12-20)32-14-18-5-7-19(8-6-18)24(29)28-34(2,30)31/h5-13,17H,3-4,14-15H2,1-2H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499439
PNG
(4-((3-(2-(cyclopropylmethoxy)-3- methylpyridin-4-y...)
Show SMILES Cc1c(OCC2CC2)nccc1-c1cc(OCc2ccc(cc2F)C(=O)NS(C)(=O)=O)ccc1F
Show InChI InChI=1S/C25H24F2N2O5S/c1-15-20(9-10-28-25(15)34-13-16-3-4-16)21-12-19(7-8-22(21)26)33-14-18-6-5-17(11-23(18)27)24(30)29-35(2,31)32/h5-12,16H,3-4,13-14H2,1-2H3,(H,29,30)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499443
PNG
(4-((3-(5-(cyclopropylmethoxy) pyrazin- 2-yl)-4-flu...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2ccc(F)c(c2)-c2cnc(OCC3CC3)cn2)c(F)c1
Show InChI InChI=1S/C23H21F2N3O5S/c1-34(30,31)28-23(29)15-4-5-16(20(25)8-15)13-32-17-6-7-19(24)18(9-17)21-10-27-22(11-26-21)33-12-14-2-3-14/h4-11,14H,2-3,12-13H2,1H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499452
PNG
(4-((3-(6-(cyclopropylmethoxy)- 5-methylpyrimidin-4...)
Show SMILES Cc1c(OCC2CC2)ncnc1-c1cccc(OCc2ccc(cc2F)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C24H24FN3O5S/c1-15-22(26-14-27-24(15)33-12-16-6-7-16)17-4-3-5-20(10-17)32-13-19-9-8-18(11-21(19)25)23(29)28-34(2,30)31/h3-5,8-11,14,16H,6-7,12-13H2,1-2H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499315
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)phenox...)
Show SMILES O=C(NS(=O)(=O)C1CC1)c1ccc(COc2cccc(c2)-c2ccc(OCC3CC3)nc2)cc1
Show InChI InChI=1S/C26H26N2O5S/c29-26(28-34(30,31)24-11-12-24)20-8-6-19(7-9-20)16-32-23-3-1-2-21(14-23)22-10-13-25(27-15-22)33-17-18-4-5-18/h1-3,6-10,13-15,18,24H,4-5,11-12,16-17H2,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499322
PNG
(4-((2-chloro-5-(6- (cyclopropylmethoxy)pyridin-3- ...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(ccc2Cl)-c2ccc(OCC3CC3)nc2)cc1
Show InChI InChI=1S/C24H23ClN2O5S/c1-33(29,30)27-24(28)18-6-4-17(5-7-18)14-31-22-12-19(8-10-21(22)25)20-9-11-23(26-13-20)32-15-16-2-3-16/h4-13,16H,2-3,14-15H2,1H3,(H,27,28)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499343
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)-5-flu...)
Show SMILES Fc1cc(OCc2ccc(cc2F)C(=O)NS(=O)(=O)C2CC2)cc(c1)-c1ccc(OCC2CC2)nc1
Show InChI InChI=1S/C26H24F2N2O5S/c27-21-9-20(18-5-8-25(29-13-18)35-14-16-1-2-16)10-22(12-21)34-15-19-4-3-17(11-24(19)28)26(31)30-36(32,33)23-6-7-23/h3-5,8-13,16,23H,1-2,6-7,14-15H2,(H,30,31)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499348
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)-2-flu...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2F)-c2ccc(OCC3CC3)nc2)cc1
Show InChI InChI=1S/C24H23FN2O5S/c1-33(29,30)27-24(28)18-9-7-17(8-10-18)14-31-21-4-2-3-20(23(21)25)19-11-12-22(26-13-19)32-15-16-5-6-16/h2-4,7-13,16H,5-6,14-15H2,1H3,(H,27,28)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499352
PNG
(4-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)-4-flu...)
Show SMILES Fc1ccc(OCc2ccc(cc2)C(=O)NS(=O)(=O)C2CC2)cc1-c1ccc(OCC2CC2)nc1
Show InChI InChI=1S/C26H25FN2O5S/c27-24-11-8-21(13-23(24)20-7-12-25(28-14-20)34-16-17-1-2-17)33-15-18-3-5-19(6-4-18)26(30)29-35(31,32)22-9-10-22/h3-8,11-14,17,22H,1-2,9-10,15-16H2,(H,29,30)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499354
PNG
(4-((3-bromo-5-(6- (cyclopropylmethoxy)pyridin-3- y...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(Br)cc(c2)-c2ccc(OCC3CC3)nc2)cc1
Show InChI InChI=1S/C24H23BrN2O5S/c1-33(29,30)27-24(28)18-6-4-17(5-7-18)14-31-22-11-20(10-21(25)12-22)19-8-9-23(26-13-19)32-15-16-2-3-16/h4-13,16H,2-3,14-15H2,1H3,(H,27,28)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499370
PNG
(6-((3-(6- (cyclopropylmethoxy)pyridin-3- yl)phenox...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ccc(OCC3CC3)nc2)nc1
Show InChI InChI=1S/C23H23N3O5S/c1-32(28,29)26-23(27)19-7-9-20(24-13-19)15-30-21-4-2-3-17(11-21)18-8-10-22(25-12-18)31-14-16-5-6-16/h2-4,7-13,16H,5-6,14-15H2,1H3,(H,26,27)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499372
PNG
(4-(((6-(cyclopropylmethoxy)- [3,4'-bipyridin]-2'-y...)
Show SMILES O=C(NS(=O)(=O)C1CC1)c1ccc(COc2cc(ccn2)-c2ccc(OCC3CC3)nc2)cc1
Show InChI InChI=1S/C25H25N3O5S/c29-25(28-34(30,31)22-8-9-22)19-5-3-18(4-6-19)16-33-24-13-20(11-12-26-24)21-7-10-23(27-14-21)32-15-17-1-2-17/h3-7,10-14,17,22H,1-2,8-9,15-16H2,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499385
PNG
(4-(cyclopropylmethoxy)-3'-((2- fluoro-4- ((methyls...)
Show SMILES CNC(=O)c1cc(ccc1OCC1CC1)-c1cccc(OCc2ccc(cc2F)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C27H27FN2O6S/c1-29-27(32)23-13-19(10-11-25(23)36-15-17-6-7-17)18-4-3-5-22(12-18)35-16-21-9-8-20(14-24(21)28)26(31)30-37(2,33)34/h3-5,8-14,17H,6-7,15-16H2,1-2H3,(H,29,32)(H,30,31)
PDB

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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499390
PNG
(4-((3-(6-(cyclopropylmethoxy)- 2-methylpyridin-3-f...)
Show SMILES Cc1nc(OCC2CC2)ccc1-c1cccc(OCc2ccc(cc2F)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C25H25FN2O5S/c1-16-22(10-11-24(27-16)33-14-17-6-7-17)18-4-3-5-21(12-18)32-15-20-9-8-19(13-23(20)26)25(29)28-34(2,30)31/h3-5,8-13,17H,6-7,14-15H2,1-2H3,(H,28,29)
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RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499396
PNG
(4-((3-(6-(cyclopropylmethoxy)- 5-methylpyridin-3-y...)
Show SMILES Cc1cc(cnc1OCC1CC1)-c1cc(F)cc(OCc2ccc(cc2)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C25H25FN2O5S/c1-16-9-21(13-27-25(16)33-15-17-3-4-17)20-10-22(26)12-23(11-20)32-14-18-5-7-19(8-6-18)24(29)28-34(2,30)31/h5-13,17H,3-4,14-15H2,1-2H3,(H,28,29)
PDB

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n/an/a<500n/an/an/an/an/an/a



RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499416
PNG
(4-((3-(5- (cyclopropylmethoxy)pyridin-3- yl)-5-flu...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(F)cc(c2)-c2cncc(OCC3CC3)c2)cc1
Show InChI InChI=1S/C24H23FN2O5S/c1-33(29,30)27-24(28)18-6-4-17(5-7-18)14-31-22-9-19(8-21(25)11-22)20-10-23(13-26-12-20)32-15-16-2-3-16/h4-13,16H,2-3,14-15H2,1H3,(H,27,28)
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n/an/a<500n/an/an/an/an/an/a



RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499427
PNG
(4-((3-(5-(cyclobutylmethoxy)-3- methylpyridin-2- y...)
Show SMILES Cc1cc(OCC2CCC2)cnc1-c1cccc(OCc2ccc(cc2)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C26H28N2O5S/c1-18-13-24(33-16-19-5-3-6-19)15-27-25(18)22-7-4-8-23(14-22)32-17-20-9-11-21(12-10-20)26(29)28-34(2,30)31/h4,7-15,19H,3,5-6,16-17H2,1-2H3,(H,28,29)
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n/an/a<500n/an/an/an/an/an/a



RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499428
PNG
(4-((3-(5- (cyclopropylmethoxy)pyridin-2- yl)phenox...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2ccc(OCC3CC3)cn2)c(F)c1
Show InChI InChI=1S/C24H23FN2O5S/c1-33(29,30)27-24(28)18-7-8-19(22(25)12-18)15-32-20-4-2-3-17(11-20)23-10-9-21(13-26-23)31-14-16-5-6-16/h2-4,7-13,16H,5-6,14-15H2,1H3,(H,27,28)
PDB

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n/an/a<500n/an/an/an/an/an/a



RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499450
PNG
(4-((3-(6- (cyclopropylmethoxy)pyrimidin- 4-yl)-5-f...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cc(F)cc(c2)-c2cc(OCC3CC3)ncn2)cc1
Show InChI InChI=1S/C23H22FN3O5S/c1-33(29,30)27-23(28)17-6-4-16(5-7-17)12-31-20-9-18(8-19(24)10-20)21-11-22(26-14-25-21)32-13-15-2-3-15/h4-11,14-15H,2-3,12-13H2,1H3,(H,27,28)
PDB

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n/an/a<500n/an/an/an/an/an/a



RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499453
PNG
(4-((3-(6-(cyclopropylmethoxy)-5- methylpyrimidin-4...)
Show SMILES Cc1c(OCC2CC2)ncnc1-c1cc(F)cc(OCc2ccc(cc2)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C24H24FN3O5S/c1-15-22(26-14-27-24(15)33-13-16-3-4-16)19-9-20(25)11-21(10-19)32-12-17-5-7-18(8-6-17)23(29)28-34(2,30)31/h5-11,14,16H,3-4,12-13H2,1-2H3,(H,28,29)
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n/an/a<500n/an/an/an/an/an/a



RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499455
PNG
(4-((3-(2- (cyclopropylmethoxy)pyrimidin- 5-yl)phen...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2cnc(OCC3CC3)nc2)c(F)c1
Show InChI InChI=1S/C23H22FN3O5S/c1-33(29,30)27-22(28)17-7-8-18(21(24)10-17)14-31-20-4-2-3-16(9-20)19-11-25-23(26-12-19)32-13-15-5-6-15/h2-4,7-12,15H,5-6,13-14H2,1H3,(H,27,28)
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n/an/a<500n/an/an/an/an/an/a



RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent


Assay Description
This screen is used to determine the effects of compounds on human Nav1.7 channels, utilizing electrical field stimulation (EFS) system in 96-well pl...


US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499480
PNG
(US11020381, WO2012/007868 Reference compound (C))
Show SMILES CS(=O)(=O)NC(=O)c1cc(F)c(COc2cccc(c2)-c2cccnc2)cc1F
Show InChI InChI=1S/C20H16F2N2O4S/c1-29(26,27)24-20(25)17-10-18(21)15(9-19(17)22)12-28-16-6-2-4-13(8-16)14-5-3-7-23-11-14/h2-11H,12H2,1H3,(H,24,25)
PDB

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n/an/a 600n/an/an/an/an/an/a



RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent




US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499479
PNG
(US11020381, WO2012/007868 Reference compound (B))
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2cccnc2)c(F)c1
Show InChI InChI=1S/C20H17FN2O4S/c1-28(25,26)23-20(24)15-7-8-17(19(21)11-15)13-27-18-6-2-4-14(10-18)16-5-3-9-22-12-16/h2-12H,13H2,1H3,(H,23,24)
PDB

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n/an/a 1.30E+3n/an/an/an/an/an/a



RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent




US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499477
PNG
(US11020381, WO2012/007868 comparative compound Exa...)
Show SMILES Cc1nc(no1)-c1cccc(OCc2cc(F)c(cc2F)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C18H15F2N3O5S/c1-10-21-17(22-28-10)11-4-3-5-13(6-11)27-9-12-7-16(20)14(8-15(12)19)18(24)23-29(2,25)26/h3-8H,9H2,1-2H3,(H,23,24)
PDB

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n/an/a 1.30E+3n/an/an/an/an/an/a



RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent




US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499476
PNG
(US11020381, WO2012/007868 comparative compound Exa...)
Show SMILES CN1CCC(CC1)c1cccc(OCc2cc(F)c(cc2F)C(=O)NS(C)(=O)=O)c1
Show InChI InChI=1S/C21H24F2N2O4S/c1-25-8-6-14(7-9-25)15-4-3-5-17(10-15)29-13-16-11-20(23)18(12-19(16)22)21(26)24-30(2,27)28/h3-5,10-12,14H,6-9,13H2,1-2H3,(H,24,26)
PDB

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n/an/a 9.20E+3n/an/an/an/an/an/a



RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent




US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499478
PNG
(US11020381, WO2012/007868 Reference compound (A))
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)-c2cccnc2)cc1
Show InChI InChI=1S/C20H18N2O4S/c1-27(24,25)22-20(23)16-9-7-15(8-10-16)14-26-19-6-2-4-17(12-19)18-5-3-11-21-13-18/h2-13H,14H2,1H3,(H,22,23)
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n/an/a>3.00E+6n/an/an/an/an/an/a



RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent




US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499474
PNG
(US11020381, WO2012/007868 comparative compound Exa...)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(COc2cccc(c2)C2CCNCC2)cc1
Show InChI InChI=1S/C20H24N2O4S/c1-27(24,25)22-20(23)17-7-5-15(6-8-17)14-26-19-4-2-3-18(13-19)16-9-11-21-12-10-16/h2-8,13,16,21H,9-12,14H2,1H3,(H,22,23)
PDB

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n/an/a>3.00E+6n/an/an/an/an/an/a



RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent




US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM499475
PNG
(US11020381, WO2012/007868 comparative compound Exa...)
Show SMILES Cc1c(OCc2cc(F)c(cc2F)C(=O)NS(C)(=O)=O)cccc1-n1cccn1
Show InChI InChI=1S/C19H17F2N3O4S/c1-12-17(24-8-4-7-22-24)5-3-6-18(12)28-11-13-9-16(21)14(10-15(13)20)19(25)23-29(2,26)27/h3-10H,11H2,1-2H3,(H,23,25)
PDB

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n/an/a>3.00E+6n/an/an/an/an/an/a



RaQualia Pharma Inc.; XuanZhu Pharma Co., Ltd.

US Patent




US Patent US11020381 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%