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Patent code US11020395

Compile Data Set for Download or QSAR
Found 154 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Apelin receptor


(Homo sapiens (Human))
BDBM499490
PNG
(US11020395, Example 20.0 | US11020395, Example 21....)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2CC2(C)C)n1C1CCOCC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C20H29ClN6O4S/c1-12(16(30-4)17-22-10-13(21)11-23-17)32(28,29)26-19-25-24-18(15-9-20(15,2)3)27(19)14-5-7-31-8-6-14/h10-12,14-16H,5-9H2,1-4H3,(H,25,26)/t12-,15-,16-/m0/s1
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n/an/an/an/a 840n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499495
PNG
(US11020395, Example 25.0 | US11020395, Example 26....)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CC2(C)C)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C21H27ClN8O5S/c1-11(15(33-4)16-23-8-12(22)9-24-16)36(31,32)29-20-28-27-17(13-7-21(13,2)3)30(20)14-18(34-5)25-10-26-19(14)35-6/h8-11,13,15H,7H2,1-6H3,(H,28,29)/t11-,13?,15-/m0/s1
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n/an/an/an/a 4.40n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499508
PNG
(US11020395, Example 90.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CCC2)n1-c1c(OC)ncnc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C21H28N8O5S/c1-12-9-22-17(23-10-12)16(32-3)13(2)35(30,31)28-21-27-26-18(14-7-6-8-14)29(21)15-19(33-4)24-11-25-20(15)34-5/h9-11,13-14,16H,6-8H2,1-5H3,(H,27,28)/t13-,16-/m0/s1
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n/an/an/an/a 9.20n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499514
PNG
(US11020395, Example 96.0)
Show SMILES COCC1(CC1)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1C1CCC1
Show InChI InChI=1S/C19H27ClN6O4S/c1-12(15(30-3)16-21-9-14(20)10-22-16)31(27,28)25-18-24-23-17(13-5-4-6-13)26(18)19(7-8-19)11-29-2/h9-10,12-13,15H,4-8,11H2,1-3H3,(H,24,25)/t12-,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499516
PNG
(US11020395, Example 100.0 | US11020395, Example 10...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CC2(F)F)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C19H21ClF2N8O5S/c1-9(13(33-2)14-23-6-10(20)7-24-14)36(31,32)29-18-28-27-15(11-5-19(11,21)22)30(18)12-16(34-3)25-8-26-17(12)35-4/h6-9,11,13H,5H2,1-4H3,(H,28,29)/t9-,11+,13-/m0/s1
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n/an/an/an/a 140n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499527
PNG
(US11020395, Example 123.0 | US11020395, Example 12...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2C[C@H](CO)C2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H29ClN6O6S/c1-13(20(36-4)21-25-10-16(24)11-26-21)37(32,33)29-23-28-27-22(15-8-14(9-15)12-31)30(23)19-17(34-2)6-5-7-18(19)35-3/h5-7,10-11,13-15,20,31H,8-9,12H2,1-4H3,(H,28,29)/t13-,14-,15+,20-/m0/s1
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n/an/an/an/a 49n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499536
PNG
(US11020395, Example 132.0 | US11020395, Example 13...)
Show SMILES COCC1(CC1)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1[C@H]1C[C@H](CO)C1
Show InChI InChI=1S/C20H29ClN6O5S/c1-12(16(32-3)17-22-8-15(21)9-23-17)33(29,30)26-19-25-24-18(14-6-13(7-14)10-28)27(19)20(4-5-20)11-31-2/h8-9,12-14,16,28H,4-7,10-11H2,1-3H3,(H,25,26)/t12-,13-,14-,16-/m0/s1
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n/an/an/an/a 1.27E+3n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499548
PNG
(US11020395, Example 144.0 | US11020395, Example 14...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2CC[C@@H](CC2)C(F)F)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H29ClF2N8O5S/c1-12(17(37-2)19-27-9-15(24)10-28-19)40(35,36)33-23-32-31-20(14-7-5-13(6-8-14)18(25)26)34(23)16-21(38-3)29-11-30-22(16)39-4/h9-14,17-18H,5-8H2,1-4H3,(H,32,33)/t12-,13-,14+,17-/m0/s1
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n/an/an/an/a 4.80n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499558
PNG
(US11020395, Example 153.0 | US11020395, Example 15...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2C[C@H](Cl)C2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C22H26Cl2N6O5S/c1-12(19(35-4)20-25-10-15(24)11-26-20)36(31,32)29-22-28-27-21(13-8-14(23)9-13)30(22)18-16(33-2)6-5-7-17(18)34-3/h5-7,10-14,19H,8-9H2,1-4H3,(H,28,29)/t12-,13-,14-,19-/m0/s1
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n/an/an/an/a 1.5n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499576
PNG
(US11020395, Example 172.0 | US11020395, Example 17...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CC[C@H](CC2)C(F)(F)F)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H28ClF3N8O5S/c1-12(17(38-2)18-28-9-15(24)10-29-18)41(36,37)34-22-33-32-19(13-5-7-14(8-6-13)23(25,26)27)35(22)16-20(39-3)30-11-31-21(16)40-4/h9-14,17H,5-8H2,1-4H3,(H,33,34)/t12-,13-,14+,17-/m0/s1
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n/an/an/an/a 13n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499579
PNG
(US11020395, Example 175.0 | US11020395, Example 17...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2CC[C@H](F)CC2)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C22H28ClFN8O5S/c1-12(17(35-2)18-25-9-14(23)10-26-18)38(33,34)31-22-30-29-19(13-5-7-15(24)8-6-13)32(22)16-20(36-3)27-11-28-21(16)37-4/h9-13,15,17H,5-8H2,1-4H3,(H,30,31)/t12-,13-,15+,17-/m0/s1
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n/an/an/an/a 59n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499590
PNG
(US11020395, Example 184.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CC3(CCC3)C2)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H29ClN8O5S/c1-13(17(35-2)18-25-10-15(24)11-26-18)38(33,34)31-22-30-29-19(14-8-23(9-14)6-5-7-23)32(22)16-20(36-3)27-12-28-21(16)37-4/h10-14,17H,5-9H2,1-4H3,(H,30,31)/t13-,17-/m0/s1
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n/an/an/an/a 1.10n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499599
PNG
(US11020395, Example 195.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2C[C@@](C)(F)C2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H28ClFN6O5S/c1-13(19(36-5)20-26-11-15(24)12-27-20)37(32,33)30-22-29-28-21(14-9-23(2,25)10-14)31(22)18-16(34-3)7-6-8-17(18)35-4/h6-8,11-14,19H,9-10H2,1-5H3,(H,29,30)/t13-,14-,19-,23+/m0/s1
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n/an/an/an/a 2.60n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499620
PNG
(US11020395, Example 220.0 | US11020395, Example 22...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1[C@H]1CC1(F)F
Show InChI InChI=1S/C21H23ClF2N6O4S/c1-11(18-25-9-13(22)10-26-18)12(2)35(31,32)29-20-28-27-19(14-8-21(14,23)24)30(20)17-15(33-3)6-5-7-16(17)34-4/h5-7,9-12,14H,8H2,1-4H3,(H,28,29)/t11-,12-,14+/m0/s1
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n/an/an/an/a 39n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499624
PNG
(US11020395, Example 224.0 | US11020395, Example 22...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2CCC(=O)C2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H27ClN6O6S/c1-13(20(36-4)21-25-11-15(24)12-26-21)37(32,33)29-23-28-27-22(14-8-9-16(31)10-14)30(23)19-17(34-2)6-5-7-18(19)35-3/h5-7,11-14,20H,8-10H2,1-4H3,(H,28,29)/t13-,14+,20-/m0/s1
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n/an/an/an/a 160n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499638
PNG
(US11020395, Example 236.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CC3(CCC3)C2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C25H31ClN6O5S/c1-15(21(37-4)22-27-13-17(26)14-28-22)38(33,34)31-24-30-29-23(16-11-25(12-16)9-6-10-25)32(24)20-18(35-2)7-5-8-19(20)36-3/h5,7-8,13-16,21H,6,9-12H2,1-4H3,(H,30,31)/t15-,21-/m0/s1
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n/an/an/an/a 0.990n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499642
PNG
(US11020395, Example 240.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CC3(COC3)C2)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C22H27ClN8O6S/c1-12(16(34-2)17-24-7-14(23)8-25-17)38(32,33)30-21-29-28-18(13-5-22(6-13)9-37-10-22)31(21)15-19(35-3)26-11-27-20(15)36-4/h7-8,11-13,16H,5-6,9-10H2,1-4H3,(H,29,30)/t12-,16-/m0/s1
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n/an/an/an/a 71n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499483
PNG
(US11020395, Example 5.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1C1CCCCC1
Show InChI InChI=1S/C23H32N8O4S/c1-14-11-24-19(25-12-14)15(2)16(3)36(32,33)30-23-29-28-20(17-9-7-6-8-10-17)31(23)18-21(34-4)26-13-27-22(18)35-5/h11-13,15-17H,6-10H2,1-5H3,(H,29,30)/t15-,16-/m0/s1
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n/an/an/an/a 9.40n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499484
PNG
(US11020395, Example 6.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CCCCC2)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C22H29ClN8O5S/c1-13(17(34-2)18-24-10-15(23)11-25-18)37(32,33)30-22-29-28-19(14-8-6-5-7-9-14)31(22)16-20(35-3)26-12-27-21(16)36-4/h10-14,17H,5-9H2,1-4H3,(H,29,30)/t13-,17-/m0/s1
PDB

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n/an/an/an/a 7.5n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499488
PNG
(US11020395, Example 18.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1C1CCCC1
Show InChI InChI=1S/C22H30N8O4S/c1-13-10-23-18(24-11-13)14(2)15(3)35(31,32)29-22-28-27-19(16-8-6-7-9-16)30(22)17-20(33-4)25-12-26-21(17)34-5/h10-12,14-16H,6-9H2,1-5H3,(H,28,29)/t14-,15-/m0/s1
PDB

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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499490
PNG
(US11020395, Example 20.0 | US11020395, Example 21....)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2CC2(C)C)n1C1CCOCC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C20H29ClN6O4S/c1-12(16(30-4)17-22-10-13(21)11-23-17)32(28,29)26-19-25-24-18(15-9-20(15,2)3)27(19)14-5-7-31-8-6-14/h10-12,14-16H,5-9H2,1-4H3,(H,25,26)/t12-,15-,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499492
PNG
(US11020395, Example 22.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2CC2(C)C)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H29ClN6O5S/c1-13(19(35-6)20-25-11-14(24)12-26-20)36(31,32)29-22-28-27-21(15-10-23(15,2)3)30(22)18-16(33-4)8-7-9-17(18)34-5/h7-9,11-13,15,19H,10H2,1-6H3,(H,28,29)/t13-,15-,19-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499495
PNG
(US11020395, Example 25.0 | US11020395, Example 26....)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CC2(C)C)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C21H27ClN8O5S/c1-11(15(33-4)16-23-8-12(22)9-24-16)36(31,32)29-20-28-27-17(13-7-21(13,2)3)30(20)14-18(34-5)25-10-26-19(14)35-6/h8-11,13,15H,7H2,1-6H3,(H,28,29)/t11-,13?,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499502
PNG
(US11020395, Example 84.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)nnc1C1CCC1
Show InChI InChI=1S/C20H25FN8O4S/c1-11(16-22-8-14(21)9-23-16)12(2)34(30,31)28-20-27-26-17(13-6-5-7-13)29(20)15-18(32-3)24-10-25-19(15)33-4/h8-13H,5-7H2,1-4H3,(H,27,28)/t11-,12-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499503
PNG
(US11020395, Example 85.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1C1CCC1
Show InChI InChI=1S/C20H25ClN8O4S/c1-11(16-22-8-14(21)9-23-16)12(2)34(30,31)28-20-27-26-17(13-6-5-7-13)29(20)15-18(32-3)24-10-25-19(15)33-4/h8-13H,5-7H2,1-4H3,(H,27,28)/t11-,12-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499505
PNG
(US11020395, Example 87.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ccc(Cl)cn2)nnc1C1CCC1
Show InChI InChI=1S/C21H26ClN7O4S/c1-12(16-9-8-15(22)10-23-16)13(2)34(30,31)28-21-27-26-18(14-6-5-7-14)29(21)17-19(32-3)24-11-25-20(17)33-4/h8-14H,5-7H2,1-4H3,(H,27,28)/t12-,13-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499509
PNG
(US11020395, Example 91.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CCC2)n1-c1c(OC)ncnc1OC)c1ccc(Cl)cn1
Show InChI InChI=1S/C21H26ClN7O5S/c1-12(17(32-2)15-9-8-14(22)10-23-15)35(30,31)28-21-27-26-18(13-6-5-7-13)29(21)16-19(33-3)24-11-25-20(16)34-4/h8-13,17H,5-7H2,1-4H3,(H,27,28)/t12-,17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499518
PNG
(US11020395, Example 102.0 | US11020395, Example 10...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CC22CCOCC2)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H29ClN8O6S/c1-13(17(35-2)18-25-10-14(24)11-26-18)39(33,34)31-22-30-29-19(15-9-23(15)5-7-38-8-6-23)32(22)16-20(36-3)27-12-28-21(16)37-4/h10-13,15,17H,5-9H2,1-4H3,(H,30,31)/t13-,15+,17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499543
PNG
(US11020395, Example 139.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2cnc(C)cn2)nnc1C1CCC1
Show InChI InChI=1S/C23H30N6O4S/c1-14-12-25-18(13-24-14)15(2)16(3)34(30,31)28-23-27-26-22(17-8-6-9-17)29(23)21-19(32-4)10-7-11-20(21)33-5/h7,10-13,15-17H,6,8-9H2,1-5H3,(H,27,28)/t15-,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499560
PNG
(US11020395, Example 155.0 | US11020395, Example 15...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2C[C@@H](C2)OC)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H29ClN6O6S/c1-13(20(36-5)21-25-11-15(24)12-26-21)37(31,32)29-23-28-27-22(14-9-16(10-14)33-2)30(23)19-17(34-3)7-6-8-18(19)35-4/h6-8,11-14,16,20H,9-10H2,1-5H3,(H,28,29)/t13-,14-,16-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499571
PNG
(US11020395, Example 167.0 | US11020395, Example 16...)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(Cl)cn2)nnc1[C@@H]1CC[C@@H]1C(F)F
Show InChI InChI=1S/C23H29ClF2N8O5S/c1-11(2)39-17(19-27-8-13(24)9-28-19)12(3)40(35,36)33-23-32-31-20(15-7-6-14(15)18(25)26)34(23)16-21(37-4)29-10-30-22(16)38-5/h8-12,14-15,17-18H,6-7H2,1-5H3,(H,32,33)/t12-,14-,15+,17+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499574
PNG
(US11020395, Example 169.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CC[C@H]2CN)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H30ClN7O5S/c1-13(20(36-4)21-26-11-15(24)12-27-21)37(32,33)30-23-29-28-22(16-9-8-14(16)10-25)31(23)19-17(34-2)6-5-7-18(19)35-3/h5-7,11-14,16,20H,8-10,25H2,1-4H3,(H,29,30)/t13-,14-,16-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499591
PNG
(US11020395, Example 185.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2C[C@H](C)C2)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C21H27ClN8O5S/c1-11-6-13(7-11)18-27-28-21(30(18)15-19(34-4)25-10-26-20(15)35-5)29-36(31,32)12(2)16(33-3)17-23-8-14(22)9-24-17/h8-13,16H,6-7H2,1-5H3,(H,28,29)/t11-,12-,13-,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499595
PNG
(US11020395, Example 191.0 | US11020395, Example 19...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2C[C@H](Cl)C2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C23H29ClN6O5S/c1-13-11-25-21(26-12-13)20(35-5)14(2)36(31,32)29-23-28-27-22(15-9-16(24)10-15)30(23)19-17(33-3)7-6-8-18(19)34-4/h6-8,11-12,14-16,20H,9-10H2,1-5H3,(H,28,29)/t14-,15-,16-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499603
PNG
(US11020395, Example 199.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2CC[C@@H](CC2)C#N)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C25H30ClN7O5S/c1-15(22(38-4)23-28-13-18(26)14-29-23)39(34,35)32-25-31-30-24(17-10-8-16(12-27)9-11-17)33(25)21-19(36-2)6-5-7-20(21)37-3/h5-7,13-17,22H,8-11H2,1-4H3,(H,31,32)/t15-,16-,17+,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499608
PNG
(US11020395, Example 204.0 | US11020395, Example 20...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2C[C@]3(CC3(F)F)C2)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C22H25ClF2N8O5S/c1-11(15(36-2)16-26-7-13(23)8-27-16)39(34,35)32-20-31-30-17(12-5-21(6-12)9-22(21,24)25)33(20)14-18(37-3)28-10-29-19(14)38-4/h7-8,10-12,15H,5-6,9H2,1-4H3,(H,31,32)/t11-,12-,15-,21+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499611
PNG
(US11020395, Example 209.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](OCC(F)F)c2ncc(C)cn2)nnc1C1CCC1
Show InChI InChI=1S/C24H30F2N6O5S/c1-14-11-27-22(28-12-14)21(37-13-19(25)26)15(2)38(33,34)31-24-30-29-23(16-7-5-8-16)32(24)20-17(35-3)9-6-10-18(20)36-4/h6,9-12,15-16,19,21H,5,7-8,13H2,1-4H3,(H,30,31)/t15-,21-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499620
PNG
(US11020395, Example 220.0 | US11020395, Example 22...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1[C@H]1CC1(F)F
Show InChI InChI=1S/C21H23ClF2N6O4S/c1-11(18-25-9-13(22)10-26-18)12(2)35(31,32)29-20-28-27-19(14-8-21(14,23)24)30(20)17-15(33-3)6-5-7-16(17)34-4/h5-7,9-12,14H,8H2,1-4H3,(H,28,29)/t11-,12-,14+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499494
PNG
(US11020395, Example 24.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CC2)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C19H23ClN8O5S/c1-10(14(31-2)15-21-7-12(20)8-22-15)34(29,30)27-19-26-25-16(11-5-6-11)28(19)13-17(32-3)23-9-24-18(13)33-4/h7-11,14H,5-6H2,1-4H3,(H,26,27)/t10-,14-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499504
PNG
(US11020395, Example 86.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2cnc(C)cn2)nnc1C1CCC1
Show InChI InChI=1S/C23H32N8O5S/c1-13(2)36-19(17-11-24-14(3)10-25-17)15(4)37(32,33)30-23-29-28-20(16-8-7-9-16)31(23)18-21(34-5)26-12-27-22(18)35-6/h10-13,15-16,19H,7-9H2,1-6H3,(H,29,30)/t15-,19+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499511
PNG
(US11020395, Example 93.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CCC2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C22H27ClN6O5S/c1-13(19(34-4)20-24-11-15(23)12-25-20)35(30,31)28-22-27-26-21(14-7-5-8-14)29(22)18-16(32-2)9-6-10-17(18)33-3/h6,9-14,19H,5,7-8H2,1-4H3,(H,27,28)/t13-,19-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499512
PNG
(US11020395, Example 94.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CCC2)n1-c1c(F)cccc1F)c1ncc(Cl)cn1
Show InChI InChI=1S/C20H21ClF2N6O3S/c1-11(17(32-2)18-24-9-13(21)10-25-18)33(30,31)28-20-27-26-19(12-5-3-6-12)29(20)16-14(22)7-4-8-15(16)23/h4,7-12,17H,3,5-6H2,1-2H3,(H,27,28)/t11-,17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499529
PNG
(US11020395, Example 125.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1C1(CC1)c1ccccn1
Show InChI InChI=1S/C26H28ClN7O4S/c1-16(23-29-14-18(27)15-30-23)17(2)39(35,36)33-25-32-31-24(26(11-12-26)21-10-5-6-13-28-21)34(25)22-19(37-3)8-7-9-20(22)38-4/h5-10,13-17H,11-12H2,1-4H3,(H,32,33)/t16-,17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499536
PNG
(US11020395, Example 132.0 | US11020395, Example 13...)
Show SMILES COCC1(CC1)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1[C@H]1C[C@H](CO)C1
Show InChI InChI=1S/C20H29ClN6O5S/c1-12(16(32-3)17-22-8-15(21)9-23-17)33(29,30)26-19-25-24-18(14-6-13(7-14)10-28)27(19)20(4-5-20)11-31-2/h8-9,12-14,16,28H,4-7,10-11H2,1-3H3,(H,25,26)/t12-,13-,14-,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499538
PNG
(US11020395, Example 134.0 | US11020395, Example 13...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2C[C@H](CO)C2)n1C1CC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C18H25ClN6O4S/c1-10(15(29-2)16-20-7-13(19)8-21-16)30(27,28)24-18-23-22-17(25(18)14-3-4-14)12-5-11(6-12)9-26/h7-8,10-12,14-15,26H,3-6,9H2,1-2H3,(H,23,24)/t10-,11-,12-,15-/m0/s1
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n/an/an/an/a 1.81E+3n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499558
PNG
(US11020395, Example 153.0 | US11020395, Example 15...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2C[C@H](Cl)C2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C22H26Cl2N6O5S/c1-12(19(35-4)20-25-10-15(24)11-26-20)36(31,32)29-22-28-27-21(13-8-14(23)9-13)30(22)18-16(33-2)6-5-7-17(18)34-3/h5-7,10-14,19H,8-9H2,1-4H3,(H,28,29)/t12-,13-,14-,19-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499560
PNG
(US11020395, Example 155.0 | US11020395, Example 15...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2C[C@@H](C2)OC)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H29ClN6O6S/c1-13(20(36-5)21-25-11-15(24)12-26-21)37(31,32)29-23-28-27-22(14-9-16(10-14)33-2)30(23)19-17(34-3)7-6-8-18(19)35-4/h6-8,11-14,16,20H,9-10H2,1-5H3,(H,28,29)/t13-,14-,16-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499569
PNG
(US11020395, Example 166.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1[C@@H]1CC[C@@H]1C(F)F
Show InChI InChI=1S/C21H25ClF2N8O4S/c1-10(17-25-7-12(22)8-26-17)11(2)37(33,34)31-21-30-29-18(14-6-5-13(14)16(23)24)32(21)15-19(35-3)27-9-28-20(15)36-4/h7-11,13-14,16H,5-6H2,1-4H3,(H,30,31)/t10-,11-,13-,14+/m0/s1
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n/an/an/an/a 20n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499576
PNG
(US11020395, Example 172.0 | US11020395, Example 17...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CC[C@H](CC2)C(F)(F)F)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H28ClF3N8O5S/c1-12(17(38-2)18-28-9-15(24)10-29-18)41(36,37)34-22-33-32-19(13-5-7-14(8-6-13)23(25,26)27)35(22)16-20(39-3)30-11-31-21(16)40-4/h9-14,17H,5-8H2,1-4H3,(H,33,34)/t12-,13-,14+,17-/m0/s1
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n/an/an/an/a 370n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499583
PNG
(US11020395, Example 179.0 | US11020395, Example 18...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2CC[C@@H]2F)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C20H24ClFN8O5S/c1-10(15(33-2)16-23-7-11(21)8-24-16)36(31,32)29-20-28-27-17(12-5-6-13(12)22)30(20)14-18(34-3)25-9-26-19(14)35-4/h7-10,12-13,15H,5-6H2,1-4H3,(H,28,29)/t10-,12+,13-,15-/m0/s1
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n/an/an/an/a 24n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499594
PNG
(US11020395, Example 188.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CC[C@H]2C)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C21H27ClN8O5S/c1-11-6-7-14(11)18-27-28-21(30(18)15-19(34-4)25-10-26-20(15)35-5)29-36(31,32)12(2)16(33-3)17-23-8-13(22)9-24-17/h8-12,14,16H,6-7H2,1-5H3,(H,28,29)/t11-,12+,14+,16+/m1/s1
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n/an/an/an/a 14n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499597
PNG
(US11020395, Example 193.0 | US11020395, Example 19...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1[C@H]1C[C@H](Cl)C1
Show InChI InChI=1S/C23H29ClN6O4S/c1-13-11-25-21(26-12-13)14(2)15(3)35(31,32)29-23-28-27-22(16-9-17(24)10-16)30(23)20-18(33-4)7-6-8-19(20)34-5/h6-8,11-12,14-17H,9-10H2,1-5H3,(H,28,29)/t14-,15-,16-,17-/m0/s1
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n/an/an/an/a 2.5n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499608
PNG
(US11020395, Example 204.0 | US11020395, Example 20...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2C[C@]3(CC3(F)F)C2)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C22H25ClF2N8O5S/c1-11(15(36-2)16-26-7-13(23)8-27-16)39(34,35)32-20-31-30-17(12-5-21(6-12)9-22(21,24)25)33(20)14-18(37-3)28-10-29-19(14)38-4/h7-8,10-12,15H,5-6,9H2,1-4H3,(H,31,32)/t11-,12-,15-,21+/m0/s1
PDB

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n/an/an/an/a 34n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499489
PNG
(US11020395, Example 19.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1C1CCCC1
Show InChI InChI=1S/C21H27ClN8O4S/c1-12(17-23-9-15(22)10-24-17)13(2)35(31,32)29-21-28-27-18(14-7-5-6-8-14)30(21)16-19(33-3)25-11-26-20(16)34-4/h9-14H,5-8H2,1-4H3,(H,28,29)/t12-,13-/m0/s1
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n/an/an/an/a 1.10n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499498
PNG
(US11020395, Example 58.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CC[C@@H]2F)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C20H24ClFN8O5S/c1-10(15(33-2)16-23-7-11(21)8-24-16)36(31,32)29-20-28-27-17(12-5-6-13(12)22)30(20)14-18(34-3)25-9-26-19(14)35-4/h7-10,12-13,15H,5-6H2,1-4H3,(H,28,29)/t10-,12-,13-,15-/m0/s1
PDB

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n/an/an/an/a 1.79E+5n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499499
PNG
(US11020395, Example 64.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CC[C@@H]2C(F)F)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C21H25ClF2N8O5S/c1-10(15(35-2)17-25-7-11(22)8-26-17)38(33,34)31-21-30-29-18(13-6-5-12(13)16(23)24)32(21)14-19(36-3)27-9-28-20(14)37-4/h7-10,12-13,15-16H,5-6H2,1-4H3,(H,30,31)/t10-,12-,13-,15-/m0/s1
PDB

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n/an/an/an/a 1.46E+5n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499501
PNG
(US11020395, Example 83.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1C1CCC1
Show InChI InChI=1S/C23H32N8O5S/c1-13(2)36-18(19-24-10-14(3)11-25-19)15(4)37(32,33)30-23-29-28-20(16-8-7-9-16)31(23)17-21(34-5)26-12-27-22(17)35-6/h10-13,15-16,18H,7-9H2,1-6H3,(H,29,30)/t15-,18+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499520
PNG
(US11020395, Example 105.0 | US11020395, Example 10...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CC22CC2)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C21H25ClN8O5S/c1-11(15(33-2)16-23-8-12(22)9-24-16)36(31,32)29-20-28-27-17(13-7-21(13)5-6-21)30(20)14-18(34-3)25-10-26-19(14)35-4/h8-11,13,15H,5-7H2,1-4H3,(H,28,29)/t11-,13+,15-/m0/s1
PDB

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n/an/an/an/a 0.920n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499534
PNG
(US11020395, Example 130.0 | US11020395, Example 13...)
Show SMILES COCC(COC)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1[C@H]1C[C@H](CO)C1
Show InChI InChI=1S/C20H31ClN6O6S/c1-12(17(33-4)18-22-7-15(21)8-23-18)34(29,30)26-20-25-24-19(14-5-13(6-14)9-28)27(20)16(10-31-2)11-32-3/h7-8,12-14,16-17,28H,5-6,9-11H2,1-4H3,(H,25,26)/t12-,13-,14-,17-/m0/s1
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n/an/an/an/a 110n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499542
PNG
(US11020395, Example 138.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CCC2)n1-c1c(OC)cccc1OC)c1cnc(C)cn1
Show InChI InChI=1S/C23H30N6O5S/c1-14-12-25-17(13-24-14)21(34-5)15(2)35(30,31)28-23-27-26-22(16-8-6-9-16)29(23)20-18(32-3)10-7-11-19(20)33-4/h7,10-13,15-16,21H,6,8-9H2,1-5H3,(H,27,28)/t15-,21-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499544
PNG
(US11020395, Example 140.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2cnc(C)cn2)nnc1C1CCC1
Show InChI InChI=1S/C25H34N6O5S/c1-15(2)36-23(19-14-26-16(3)13-27-19)17(4)37(32,33)30-25-29-28-24(18-9-7-10-18)31(25)22-20(34-5)11-8-12-21(22)35-6/h8,11-15,17-18,23H,7,9-10H2,1-6H3,(H,29,30)/t17-,23+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499564
PNG
(US11020395, Example 161.0 | US11020395, Example 17...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2CC[C@@H](CC2)OC)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H31ClN8O6S/c1-13(18(36-3)19-25-10-15(24)11-26-19)39(33,34)31-23-30-29-20(14-6-8-16(35-2)9-7-14)32(23)17-21(37-4)27-12-28-22(17)38-5/h10-14,16,18H,6-9H2,1-5H3,(H,30,31)/t13-,14-,16+,18-/m0/s1
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n/an/an/an/a 1.20E+3n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499579
PNG
(US11020395, Example 175.0 | US11020395, Example 17...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2CC[C@H](F)CC2)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C22H28ClFN8O5S/c1-12(17(35-2)18-25-9-14(23)10-26-18)38(33,34)31-22-30-29-19(13-5-7-15(24)8-6-13)32(22)16-20(36-3)27-11-28-21(16)37-4/h9-13,15,17H,5-8H2,1-4H3,(H,30,31)/t12-,13-,15+,17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499604
PNG
(US11020395, Example 200.0 | US11020395, Example 20...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CC3(CC3)C2)n1-c1c(OC)ncnc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C23H30N8O5S/c1-13-10-24-18(25-11-13)17(34-3)14(2)37(32,33)30-22-29-28-19(15-8-23(9-15)6-7-23)31(22)16-20(35-4)26-12-27-21(16)36-5/h10-12,14-15,17H,6-9H2,1-5H3,(H,29,30)/t14-,17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499615
PNG
(US11020395, Example 215.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CC[C@@H](C2)OC)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C24H31ClN6O6S/c1-14(21(37-5)22-26-12-16(25)13-27-22)38(32,33)30-24-29-28-23(15-9-10-17(11-15)34-2)31(24)20-18(35-3)7-6-8-19(20)36-4/h6-8,12-15,17,21H,9-11H2,1-5H3,(H,29,30)/t14-,15?,17-,21-/m0/s1
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n/an/an/an/a 66n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499635
PNG
(US11020395, Example 233.0 | US11020395, Example 23...)
Show SMILES CO[C@H]1CCC[C@H]1c1nnc(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C27H38N6O6S/c1-16(2)39-24(25-28-14-17(3)15-29-25)18(4)40(34,35)32-27-31-30-26(19-10-8-11-20(19)36-5)33(27)23-21(37-6)12-9-13-22(23)38-7/h9,12-16,18-20,24H,8,10-11H2,1-7H3,(H,31,32)/t18-,19+,20-,24+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499635
PNG
(US11020395, Example 233.0 | US11020395, Example 23...)
Show SMILES CO[C@H]1CCC[C@H]1c1nnc(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C27H38N6O6S/c1-16(2)39-24(25-28-14-17(3)15-29-25)18(4)40(34,35)32-27-31-30-26(19-10-8-11-20(19)36-5)33(27)23-21(37-6)12-9-13-22(23)38-7/h9,12-16,18-20,24H,8,10-11H2,1-7H3,(H,31,32)/t18-,19+,20-,24+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499640
PNG
(US11020395, Example 238.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CC(C2)(OC)OC)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C22H29ClN8O7S/c1-12(16(34-2)17-24-9-14(23)10-25-17)39(32,33)30-21-29-28-18(13-7-22(8-13,37-5)38-6)31(21)15-19(35-3)26-11-27-20(15)36-4/h9-13,16H,7-8H2,1-6H3,(H,29,30)/t12-,16-/m0/s1
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n/an/an/an/a 120n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499641
PNG
(US11020395, Example 239.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CC3(CC3)C2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C24H29ClN6O5S/c1-14(20(36-4)21-26-12-16(25)13-27-21)37(32,33)30-23-29-28-22(15-10-24(11-15)8-9-24)31(23)19-17(34-2)6-5-7-18(19)35-3/h5-7,12-15,20H,8-11H2,1-4H3,(H,29,30)/t14-,20-/m0/s1
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n/an/an/an/a 0.640n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499493
PNG
(US11020395, Example 23.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CC2(C)C)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H29ClN6O5S/c1-13(19(35-6)20-25-11-14(24)12-26-20)36(31,32)29-22-28-27-21(15-10-23(15,2)3)30(22)18-16(33-4)8-7-9-17(18)34-5/h7-9,11-13,15,19H,10H2,1-6H3,(H,28,29)/t13-,15?,19-/m0/s1
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n/an/an/an/a 14n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499500
PNG
(US11020395, Example 82.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CCC2)n1-c1c(OC)ncnc1OC)c1cnc(C)cn1
Show InChI InChI=1S/C21H28N8O5S/c1-12-9-23-15(10-22-12)17(32-3)13(2)35(30,31)28-21-27-26-18(14-7-6-8-14)29(21)16-19(33-4)24-11-25-20(16)34-5/h9-11,13-14,17H,6-8H2,1-5H3,(H,27,28)/t13-,17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499507
PNG
(US11020395, Example 89.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(Cl)cn2)nnc1C1CCC1
Show InChI InChI=1S/C22H29ClN8O5S/c1-12(2)36-17(18-24-9-15(23)10-25-18)13(3)37(32,33)30-22-29-28-19(14-7-6-8-14)31(22)16-20(34-4)26-11-27-21(16)35-5/h9-14,17H,6-8H2,1-5H3,(H,29,30)/t13-,17+/m0/s1
PDB

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n/an/an/an/a 0.740n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499524
PNG
(US11020395, Example 120.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CC(C)(C)C2)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C22H29ClN8O5S/c1-12(16(34-4)17-24-9-14(23)10-25-17)37(32,33)30-21-29-28-18(13-7-22(2,3)8-13)31(21)15-19(35-5)26-11-27-20(15)36-6/h9-13,16H,7-8H2,1-6H3,(H,29,30)/t12-,16-/m0/s1
PDB

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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499525
PNG
(US11020395, Example 121.0 | US11020395, Example 12...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2C[C@@H](C2)C#N)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H26ClN7O5S/c1-13(20(36-4)21-26-11-16(24)12-27-21)37(32,33)30-23-29-28-22(15-8-14(9-15)10-25)31(23)19-17(34-2)6-5-7-18(19)35-3/h5-7,11-15,20H,8-9H2,1-4H3,(H,29,30)/t13-,14-,15+,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499538
PNG
(US11020395, Example 134.0 | US11020395, Example 13...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2C[C@H](CO)C2)n1C1CC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C18H25ClN6O4S/c1-10(15(29-2)16-20-7-13(19)8-21-16)30(27,28)24-18-23-22-17(25(18)14-3-4-14)12-5-11(6-12)9-26/h7-8,10-12,14-15,26H,3-6,9H2,1-2H3,(H,23,24)/t10-,11-,12-,15-/m0/s1
PDB

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n/an/an/an/a 1.33E+3n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499546
PNG
(US11020395, Example 142.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1C1CCC1
Show InChI InChI=1S/C25H34N6O5S/c1-15(2)36-22(23-26-13-16(3)14-27-23)17(4)37(32,33)30-25-29-28-24(18-9-7-10-18)31(25)21-19(34-5)11-8-12-20(21)35-6/h8,11-15,17-18,22H,7,9-10H2,1-6H3,(H,29,30)/t17-,22+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499547
PNG
(US11020395, Example 143.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1C1CCC1
Show InChI InChI=1S/C22H27ClN6O4S/c1-13(20-24-11-16(23)12-25-20)14(2)34(30,31)28-22-27-26-21(15-7-5-8-15)29(22)19-17(32-3)9-6-10-18(19)33-4/h6,9-15H,5,7-8H2,1-4H3,(H,27,28)/t13-,14-/m0/s1
PDB

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n/an/an/an/a 4.10n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499550
PNG
(US11020395, Example 146.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CC[C@@H]2C(F)F)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C21H25ClF2N8O5S/c1-10(15(35-2)17-25-7-11(22)8-26-17)38(33,34)31-21-30-29-18(13-6-5-12(13)16(23)24)32(21)14-19(36-3)27-9-28-20(14)37-4/h7-10,12-13,15-16H,5-6H2,1-4H3,(H,30,31)/t10-,12-,13?,15-/m0/s1
PDB

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n/an/an/an/a 26n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499551
PNG
(US11020395, Example 147.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CC(F)(F)C2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C22H25ClF2N6O5S/c1-12(18(36-4)19-26-10-14(23)11-27-19)37(32,33)30-21-29-28-20(13-8-22(24,25)9-13)31(21)17-15(34-2)6-5-7-16(17)35-3/h5-7,10-13,18H,8-9H2,1-4H3,(H,29,30)/t12-,18-/m0/s1
PDB

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n/an/an/an/a 6.40n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499554
PNG
(US11020395, Example 150.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2C[C@@H](C2)C(F)(F)F)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H26ClF3N6O5S/c1-12(19(38-4)20-28-10-15(24)11-29-20)39(34,35)32-22-31-30-21(13-8-14(9-13)23(25,26)27)33(22)18-16(36-2)6-5-7-17(18)37-3/h5-7,10-14,19H,8-9H2,1-4H3,(H,31,32)/t12-,13-,14-,19-/m0/s1
PDB

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n/an/an/an/a 6.80n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499565
PNG
(US11020395, Example 162.0 | US11020395, Example 16...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2C[C@H](F)C2)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C20H24ClFN8O5S/c1-10(15(33-2)16-23-7-12(21)8-24-16)36(31,32)29-20-28-27-17(11-5-13(22)6-11)30(20)14-18(34-3)25-9-26-19(14)35-4/h7-11,13,15H,5-6H2,1-4H3,(H,28,29)/t10-,11-,13+,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499610
PNG
(US11020395, Example 208.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2CC[C@H]2C)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H29ClN6O5S/c1-13-9-10-16(13)22-27-28-23(30(22)19-17(33-3)7-6-8-18(19)34-4)29-36(31,32)14(2)20(35-5)21-25-11-15(24)12-26-21/h6-8,11-14,16,20H,9-10H2,1-5H3,(H,28,29)/t13-,14+,16-,20+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499617
PNG
(US11020395, Example 217.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(n1-c1c(OC)cccc1OC)C12CC(C1)C2)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H27ClN6O5S/c1-13(19(35-4)20-25-11-15(24)12-26-20)36(31,32)29-22-28-27-21(23-8-14(9-23)10-23)30(22)18-16(33-2)6-5-7-17(18)34-3/h5-7,11-14,19H,8-10H2,1-4H3,(H,28,29)/t13-,14?,19-,23?/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499618
PNG
(US11020395, Example 218.0 | US11020395, Example 21...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1[C@H]1CC11CC1
Show InChI InChI=1S/C23H27ClN6O4S/c1-13(20-25-11-15(24)12-26-20)14(2)35(31,32)29-22-28-27-21(16-10-23(16)8-9-23)30(22)19-17(33-3)6-5-7-18(19)34-4/h5-7,11-14,16H,8-10H2,1-4H3,(H,28,29)/t13-,14-,16+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499622
PNG
(US11020395, Example 222.0 | US11020395, Example 22...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CC22CC2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H27ClN6O5S/c1-13(19(35-4)20-25-11-14(24)12-26-20)36(31,32)29-22-28-27-21(15-10-23(15)8-9-23)30(22)18-16(33-2)6-5-7-17(18)34-3/h5-7,11-13,15,19H,8-10H2,1-4H3,(H,28,29)/t13-,15+,19-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499634
PNG
(US11020395, Example 232.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1[C@@H]1CCC(F)(F)C1
Show InChI InChI=1S/C26H34F2N6O5S/c1-15(2)39-22(23-29-13-16(3)14-30-23)17(4)40(35,36)33-25-32-31-24(18-10-11-26(27,28)12-18)34(25)21-19(37-5)8-7-9-20(21)38-6/h7-9,13-15,17-18,22H,10-12H2,1-6H3,(H,32,33)/t17-,18+,22+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499643
PNG
(US11020395, Example 241.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CCCC2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H29ClN6O5S/c1-14(20(35-4)21-25-12-16(24)13-26-21)36(31,32)29-23-28-27-22(15-8-5-6-9-15)30(23)19-17(33-2)10-7-11-18(19)34-3/h7,10-15,20H,5-6,8-9H2,1-4H3,(H,28,29)/t14-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499482
PNG
(US11020395, Example 4.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1C1CCC1
Show InChI InChI=1S/C21H28N8O4S/c1-12-9-22-17(23-10-12)13(2)14(3)34(30,31)28-21-27-26-18(15-7-6-8-15)29(21)16-19(32-4)24-11-25-20(16)33-5/h9-11,13-15H,6-8H2,1-5H3,(H,27,28)/t13-,14-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499516
PNG
(US11020395, Example 100.0 | US11020395, Example 10...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CC2(F)F)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C19H21ClF2N8O5S/c1-9(13(33-2)14-23-6-10(20)7-24-14)36(31,32)29-18-28-27-15(11-5-19(11,21)22)30(18)12-16(34-3)25-8-26-17(12)35-4/h6-9,11,13H,5H2,1-4H3,(H,28,29)/t9-,11+,13-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499518
PNG
(US11020395, Example 102.0 | US11020395, Example 10...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CC22CCOCC2)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H29ClN8O6S/c1-13(17(35-2)18-25-10-14(24)11-26-18)39(33,34)31-22-30-29-19(15-9-23(15)5-7-38-8-6-23)32(22)16-20(36-3)27-12-28-21(16)37-4/h10-13,15,17H,5-9H2,1-4H3,(H,30,31)/t13-,15+,17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499523
PNG
(US11020395, Example 119.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CC(C)(C)C2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C24H31ClN6O5S/c1-14(20(36-6)21-26-12-16(25)13-27-21)37(32,33)30-23-29-28-22(15-10-24(2,3)11-15)31(23)19-17(34-4)8-7-9-18(19)35-5/h7-9,12-15,20H,10-11H2,1-6H3,(H,29,30)/t14-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499552
PNG
(US11020395, Example 148.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2C[C@H](C)C2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H29ClN6O5S/c1-13-9-15(10-13)22-27-28-23(30(22)19-17(33-3)7-6-8-18(19)34-4)29-36(31,32)14(2)20(35-5)21-25-11-16(24)12-26-21/h6-8,11-15,20H,9-10H2,1-5H3,(H,28,29)/t13-,14-,15-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499555
PNG
(US11020395, Example 151.0 | US11020395, Example 15...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2C[C@H](F)C2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C22H26ClFN6O5S/c1-12(19(35-4)20-25-10-14(23)11-26-20)36(31,32)29-22-28-27-21(13-8-15(24)9-13)30(22)18-16(33-2)6-5-7-17(18)34-3/h5-7,10-13,15,19H,8-9H2,1-4H3,(H,28,29)/t12-,13-,15-,19-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499562
PNG
(US11020395, Example 159.0 | US11020395, Example 16...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CCC2(F)F)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C22H25ClF2N6O5S/c1-12(18(36-4)19-26-10-13(23)11-27-19)37(32,33)30-21-29-28-20(14-8-9-22(14,24)25)31(21)17-15(34-2)6-5-7-16(17)35-3/h5-7,10-12,14,18H,8-9H2,1-4H3,(H,29,30)/t12-,14+,18-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499571
PNG
(US11020395, Example 167.0 | US11020395, Example 16...)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(Cl)cn2)nnc1[C@@H]1CC[C@@H]1C(F)F
Show InChI InChI=1S/C23H29ClF2N8O5S/c1-11(2)39-17(19-27-8-13(24)9-28-19)12(3)40(35,36)33-23-32-31-20(15-7-6-14(15)18(25)26)34(23)16-21(37-4)29-10-30-22(16)38-5/h8-12,14-15,17-18H,6-7H2,1-5H3,(H,32,33)/t12-,14-,15+,17+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499575
PNG
(US11020395, Example 170.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2CC[C@H]2CN)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H30ClN7O5S/c1-13(20(36-4)21-26-11-15(24)12-27-21)37(32,33)30-23-29-28-22(16-9-8-14(16)10-25)31(23)19-17(34-2)6-5-7-18(19)35-3/h5-7,11-14,16,20H,8-10,25H2,1-4H3,(H,29,30)/t13-,14-,16+,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499586
PNG
(US11020395, Example 181.0 | US11020395, Example 18...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CC[C@@H]2F)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C20H24ClFN8O5S/c1-10(15(33-2)16-23-7-11(21)8-24-16)36(31,32)29-20-28-27-17(12-5-6-13(12)22)30(20)14-18(34-3)25-9-26-19(14)35-4/h7-10,12-13,15H,5-6H2,1-4H3,(H,28,29)/t10-,12-,13-,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499586
PNG
(US11020395, Example 181.0 | US11020395, Example 18...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CC[C@@H]2F)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C20H24ClFN8O5S/c1-10(15(33-2)16-23-7-11(21)8-24-16)36(31,32)29-20-28-27-17(12-5-6-13(12)22)30(20)14-18(34-3)25-9-26-19(14)35-4/h7-10,12-13,15H,5-6H2,1-4H3,(H,28,29)/t10-,12-,13-,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499606
PNG
(US11020395, Example 202.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1C1CC2(CC2)C1
Show InChI InChI=1S/C23H30N8O4S/c1-13-10-24-18(25-11-13)14(2)15(3)36(32,33)30-22-29-28-19(16-8-23(9-16)6-7-23)31(22)17-20(34-4)26-12-27-21(17)35-5/h10-12,14-16H,6-9H2,1-5H3,(H,29,30)/t14-,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499607
PNG
(US11020395, Example 203.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CC(Cl)(Cl)C2)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C20H23Cl3N8O5S/c1-10(14(34-2)15-24-7-12(21)8-25-15)37(32,33)30-19-29-28-16(11-5-20(22,23)6-11)31(19)13-17(35-3)26-9-27-18(13)36-4/h7-11,14H,5-6H2,1-4H3,(H,29,30)/t10-,14-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499627
PNG
(US11020395, Example 226.0 | US11020395, Example 22...)
Show SMILES CO[C@H]1C[C@H](C1)c1nnc(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C26H36N6O6S/c1-15(2)38-23(24-27-13-16(3)14-28-24)17(4)39(33,34)31-26-30-29-25(18-11-19(12-18)35-5)32(26)22-20(36-6)9-8-10-21(22)37-7/h8-10,13-15,17-19,23H,11-12H2,1-7H3,(H,30,31)/t17-,18-,19+,23+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499629
PNG
(US11020395, Example 228.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1[C@@H]1C2CC1[C@H]2O
Show InChI InChI=1S/C26H34N6O6S/c1-13(2)38-23(24-27-11-14(3)12-28-24)15(4)39(34,35)31-26-30-29-25(20-16-10-17(20)22(16)33)32(26)21-18(36-5)8-7-9-19(21)37-6/h7-9,11-13,15-17,20,22-23,33H,10H2,1-6H3,(H,30,31)/t15-,16?,17?,20-,22+,23+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499481
PNG
(US11020395, Example 3.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1C1CC1
Show InChI InChI=1S/C20H26N8O4S/c1-11-8-21-16(22-9-11)12(2)13(3)33(29,30)27-20-26-25-17(14-6-7-14)28(20)15-18(31-4)23-10-24-19(15)32-5/h8-10,12-14H,6-7H2,1-5H3,(H,26,27)/t12-,13-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499506
PNG
(US11020395, Example 88.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2cnc(C)cn2)nnc1C1CCC1
Show InChI InChI=1S/C21H28N8O4S/c1-12-9-23-16(10-22-12)13(2)14(3)34(30,31)28-21-27-26-18(15-7-6-8-15)29(21)17-19(32-4)24-11-25-20(17)33-5/h9-11,13-15H,6-8H2,1-5H3,(H,27,28)/t13-,14-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499513
PNG
(US11020395, Example 95.0)
Show SMILES COCC(COC)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1C1CCC1
Show InChI InChI=1S/C19H29ClN6O5S/c1-12(16(31-4)17-21-8-14(20)9-22-17)32(27,28)25-19-24-23-18(13-6-5-7-13)26(19)15(10-29-2)11-30-3/h8-9,12-13,15-16H,5-7,10-11H2,1-4H3,(H,24,25)/t12-,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499515
PNG
(US11020395, Example 97.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CCC2)n1C1CCOCC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C19H27ClN6O4S/c1-12(16(29-2)17-21-10-14(20)11-22-17)31(27,28)25-19-24-23-18(13-4-3-5-13)26(19)15-6-8-30-9-7-15/h10-13,15-16H,3-9H2,1-2H3,(H,24,25)/t12-,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499520
PNG
(US11020395, Example 105.0 | US11020395, Example 10...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CC22CC2)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C21H25ClN8O5S/c1-11(15(33-2)16-23-8-12(22)9-24-16)36(31,32)29-20-28-27-17(13-7-21(13)5-6-21)30(20)14-18(34-3)25-10-26-19(14)35-4/h8-11,13,15H,5-7H2,1-4H3,(H,28,29)/t11-,13+,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499522
PNG
(US11020395, Example 118.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CC(=C)C2)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C21H25ClN8O5S/c1-11-6-13(7-11)18-27-28-21(30(18)15-19(34-4)25-10-26-20(15)35-5)29-36(31,32)12(2)16(33-3)17-23-8-14(22)9-24-17/h8-10,12-13,16H,1,6-7H2,2-5H3,(H,28,29)/t12-,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499525
PNG
(US11020395, Example 121.0 | US11020395, Example 12...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2C[C@@H](C2)C#N)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H26ClN7O5S/c1-13(20(36-4)21-26-11-16(24)12-27-21)37(32,33)30-23-29-28-22(15-8-14(9-15)10-25)31(23)19-17(34-2)6-5-7-18(19)35-3/h5-7,11-15,20H,8-9H2,1-4H3,(H,29,30)/t13-,14-,15+,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499527
PNG
(US11020395, Example 123.0 | US11020395, Example 12...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2C[C@H](CO)C2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H29ClN6O6S/c1-13(20(36-4)21-25-10-16(24)11-26-21)37(32,33)29-23-28-27-22(15-8-14(9-15)12-31)30(23)19-17(34-2)6-5-7-18(19)35-3/h5-7,10-11,13-15,20,31H,8-9,12H2,1-4H3,(H,28,29)/t13-,14-,15+,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499531
PNG
(US11020395, Example 128.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CCC2)n1C(C)C)c1ncc(Cl)cn1
Show InChI InChI=1S/C17H25ClN6O3S/c1-10(2)24-16(12-6-5-7-12)21-22-17(24)23-28(25,26)11(3)14(27-4)15-19-8-13(18)9-20-15/h8-12,14H,5-7H2,1-4H3,(H,22,23)/t11-,14-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499534
PNG
(US11020395, Example 130.0 | US11020395, Example 13...)
Show SMILES COCC(COC)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1[C@H]1C[C@H](CO)C1
Show InChI InChI=1S/C20H31ClN6O6S/c1-12(17(33-4)18-22-7-15(21)8-23-18)34(29,30)26-20-25-24-19(14-5-13(6-14)9-28)27(20)16(10-31-2)11-32-3/h7-8,12-14,16-17,28H,5-6,9-11H2,1-4H3,(H,25,26)/t12-,13-,14-,17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499540
PNG
(US11020395, Example 136.0 | US11020395, Example 13...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2C[C@H](CO)C2)n1C(C)C)c1ncc(Cl)cn1
Show InChI InChI=1S/C18H27ClN6O4S/c1-10(2)25-17(13-5-12(6-13)9-26)22-23-18(25)24-30(27,28)11(3)15(29-4)16-20-7-14(19)8-21-16/h7-8,10-13,15,26H,5-6,9H2,1-4H3,(H,23,24)/t11-,12-,13-,15-/m0/s1
PDB

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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499540
PNG
(US11020395, Example 136.0 | US11020395, Example 13...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2C[C@H](CO)C2)n1C(C)C)c1ncc(Cl)cn1
Show InChI InChI=1S/C18H27ClN6O4S/c1-10(2)25-17(13-5-12(6-13)9-26)22-23-18(25)24-30(27,28)11(3)15(29-4)16-20-7-14(19)8-21-16/h7-8,10-13,15,26H,5-6,9H2,1-4H3,(H,23,24)/t11-,12-,13-,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499545
PNG
(US11020395, Example 141.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CCC2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C23H30N6O5S/c1-14-12-24-21(25-13-14)20(34-5)15(2)35(30,31)28-23-27-26-22(16-8-6-9-16)29(23)19-17(32-3)10-7-11-18(19)33-4/h7,10-13,15-16,20H,6,8-9H2,1-5H3,(H,27,28)/t15-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499548
PNG
(US11020395, Example 144.0 | US11020395, Example 14...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2CC[C@@H](CC2)C(F)F)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H29ClF2N8O5S/c1-12(17(37-2)19-27-9-15(24)10-28-19)40(35,36)33-23-32-31-20(14-7-5-13(6-8-14)18(25)26)34(23)16-21(38-3)29-11-30-22(16)39-4/h9-14,17-18H,5-8H2,1-4H3,(H,32,33)/t12-,13-,14+,17-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499555
PNG
(US11020395, Example 151.0 | US11020395, Example 15...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2C[C@H](F)C2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C22H26ClFN6O5S/c1-12(19(35-4)20-25-10-14(23)11-26-20)36(31,32)29-22-28-27-21(13-8-15(24)9-13)30(22)18-16(33-2)6-5-7-17(18)34-3/h5-7,10-13,15,19H,8-9H2,1-4H3,(H,28,29)/t12-,13-,15-,19-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499562
PNG
(US11020395, Example 159.0 | US11020395, Example 16...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CCC2(F)F)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C22H25ClF2N6O5S/c1-12(18(36-4)19-26-10-13(23)11-27-19)37(32,33)30-21-29-28-20(14-8-9-22(14,24)25)31(21)17-15(34-2)6-5-7-16(17)35-3/h5-7,10-12,14,18H,8-9H2,1-4H3,(H,29,30)/t12-,14+,18-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499589
PNG
(US11020395, Example 183.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CC3(CC3)C2)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C22H27ClN8O5S/c1-12(16(34-2)17-24-9-14(23)10-25-17)37(32,33)30-21-29-28-18(13-7-22(8-13)5-6-22)31(21)15-19(35-3)26-11-27-20(15)36-4/h9-13,16H,5-8H2,1-4H3,(H,29,30)/t12-,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499600
PNG
(US11020395, Example 196.0 | US11020395, Example 19...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CC(=O)C2(C)C)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C24H29ClN6O6S/c1-13(20(37-6)21-26-11-14(25)12-27-21)38(33,34)30-23-29-28-22(15-10-18(32)24(15,2)3)31(23)19-16(35-4)8-7-9-17(19)36-5/h7-9,11-13,15,20H,10H2,1-6H3,(H,29,30)/t13-,15+,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499602
PNG
(US11020395, Example 198.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2C[C@@](C)(F)C2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H28ClFN6O5S/c1-13(19(36-5)20-26-11-15(24)12-27-20)37(32,33)30-22-29-28-21(14-9-23(2,25)10-14)31(22)18-16(34-3)7-6-8-17(18)35-4/h6-8,11-14,19H,9-10H2,1-5H3,(H,29,30)/t13-,14-,19-,23+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499604
PNG
(US11020395, Example 200.0 | US11020395, Example 20...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CC3(CC3)C2)n1-c1c(OC)ncnc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C23H30N8O5S/c1-13-10-24-18(25-11-13)17(34-3)14(2)37(32,33)30-22-29-28-19(15-8-23(9-15)6-7-23)31(22)16-20(35-4)26-12-27-21(16)36-5/h10-12,14-15,17H,6-9H2,1-5H3,(H,29,30)/t14-,17-/m0/s1
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n/an/an/an/a 4.60n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499614
PNG
(US11020395, Example 214.0 | US11020395, Example 21...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CC[C@H](C2)OC)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C24H31ClN6O6S/c1-14(21(37-5)22-26-12-16(25)13-27-22)38(32,33)30-24-29-28-23(15-9-10-17(11-15)34-2)31(24)20-18(35-3)7-6-8-19(20)36-4/h6-8,12-15,17,21H,9-11H2,1-5H3,(H,29,30)/t14-,15?,17+,21-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499618
PNG
(US11020395, Example 218.0 | US11020395, Example 21...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1[C@H]1CC11CC1
Show InChI InChI=1S/C23H27ClN6O4S/c1-13(20-25-11-15(24)12-26-20)14(2)35(31,32)29-22-28-27-21(16-10-23(16)8-9-23)30(22)19-17(33-3)6-5-7-18(19)34-4/h5-7,11-14,16H,8-10H2,1-4H3,(H,28,29)/t13-,14-,16+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499624
PNG
(US11020395, Example 224.0 | US11020395, Example 22...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2CCC(=O)C2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H27ClN6O6S/c1-13(20(36-4)21-25-11-15(24)12-26-21)37(32,33)29-23-28-27-22(14-8-9-16(31)10-14)30(23)19-17(34-2)6-5-7-18(19)35-3/h5-7,11-14,20H,8-10H2,1-4H3,(H,28,29)/t13-,14+,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499633
PNG
(US11020395, Example 231.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1C1C[C@@](C)(O)C1
Show InChI InChI=1S/C26H36N6O6S/c1-15(2)38-22(23-27-13-16(3)14-28-23)17(4)39(34,35)31-25-30-29-24(18-11-26(5,33)12-18)32(25)21-19(36-6)9-8-10-20(21)37-7/h8-10,13-15,17-18,22,33H,11-12H2,1-7H3,(H,30,31)/t17-,18?,22+,26-/m0/s1
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n/an/an/an/a 220n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499639
PNG
(US11020395, Example 237.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2C[C@](C)(F)C2)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C21H26ClFN8O5S/c1-11(15(34-3)16-24-8-13(22)9-25-16)37(32,33)30-20-29-28-17(12-6-21(2,23)7-12)31(20)14-18(35-4)26-10-27-19(14)36-5/h8-12,15H,6-7H2,1-5H3,(H,29,30)/t11-,12-,15-,21-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499485
PNG
(US11020395, Example 7.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CCC2)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C20H25ClN8O5S/c1-11(15(32-2)16-22-8-13(21)9-23-16)35(30,31)28-20-27-26-17(12-6-5-7-12)29(20)14-18(33-3)24-10-25-19(14)34-4/h8-12,15H,5-7H2,1-4H3,(H,27,28)/t11-,15-/m0/s1
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n/an/an/an/a 66n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499486
PNG
(US11020395, Example 16.0 | US11046680, Example 329...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)N\C(S)=N/c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C18H24N4O5S2/c1-11-9-19-17(20-10-11)16(27-5)12(2)29(23,24)22-18(28)21-15-13(25-3)7-6-8-14(15)26-4/h6-10,12,16H,1-5H3,(H2,21,22,28)/t12-,16-/m0/s1
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n/an/an/an/a 22n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499487
PNG
(US11020395, Example 17.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1C1CCCC1
Show InChI InChI=1S/C24H32N6O4S/c1-15-13-25-22(26-14-15)16(2)17(3)35(31,32)29-24-28-27-23(18-9-6-7-10-18)30(24)21-19(33-4)11-8-12-20(21)34-5/h8,11-14,16-18H,6-7,9-10H2,1-5H3,(H,28,29)/t16-,17-/m0/s1
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n/an/an/an/a 1.10n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499497
PNG
(US11020395, Example 42.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(n1-c1c(OC)ncnc1OC)C12C3C4C5C3C1C5C24)c1ncc(Cl)cn1
Show InChI InChI=1S/C24H25ClN8O5S/c1-8(18(36-2)19-26-5-9(25)6-27-19)39(34,35)32-23-31-30-22(24-14-11-10-12(14)16(24)13(10)15(11)24)33(23)17-20(37-3)28-7-29-21(17)38-4/h5-8,10-16,18H,1-4H3,(H,31,32)/t8-,10?,11?,12?,13?,14?,15?,16?,18-,24?/m0/s1
PDB

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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499510
PNG
(US11020395, Example 92.0)
Show SMILES COc1cnc(nc1)[C@@H](C)[C@H](C)S(=O)(=O)Nc1nnc(C2CCC2)n1-c1c(OC)ncnc1OC
Show InChI InChI=1S/C21H28N8O5S/c1-12(17-22-9-15(32-3)10-23-17)13(2)35(30,31)28-21-27-26-18(14-7-6-8-14)29(21)16-19(33-4)24-11-25-20(16)34-5/h9-14H,6-8H2,1-5H3,(H,27,28)/t12-,13-/m0/s1
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n/an/an/an/a 5.70n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499530
PNG
(US11020395, Example 126.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1C1(CC1)c1ccccn1
Show InChI InChI=1S/C27H31N7O4S/c1-17-15-29-24(30-16-17)18(2)19(3)39(35,36)33-26-32-31-25(27(12-13-27)22-11-6-7-14-28-22)34(26)23-20(37-4)9-8-10-21(23)38-5/h6-11,14-16,18-19H,12-13H2,1-5H3,(H,32,33)/t18-,19-/m0/s1
PDB

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n/an/an/an/a 4.20E+3n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499553
PNG
(US11020395, Example 149.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2C[C@@H](C2)C(F)(F)F)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H26ClF3N6O5S/c1-12(19(38-4)20-28-10-15(24)11-29-20)39(34,35)32-22-31-30-21(13-8-14(9-13)23(25,26)27)33(22)18-16(36-2)6-5-7-17(18)37-3/h5-7,10-14,19H,8-9H2,1-4H3,(H,31,32)/t12-,13-,14-,19-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499564
PNG
(US11020395, Example 161.0 | US11020395, Example 17...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2CC[C@@H](CC2)OC)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H31ClN8O6S/c1-13(18(36-3)19-25-10-15(24)11-26-19)39(33,34)31-23-30-29-20(14-6-8-16(35-2)9-7-14)32(23)17-21(37-4)27-12-28-22(17)38-5/h10-14,16,18H,6-9H2,1-5H3,(H,30,31)/t13-,14-,16+,18-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499565
PNG
(US11020395, Example 162.0 | US11020395, Example 16...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2C[C@H](F)C2)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C20H24ClFN8O5S/c1-10(15(33-2)16-23-7-12(21)8-24-16)36(31,32)29-20-28-27-17(11-5-13(22)6-11)30(20)14-18(34-3)25-9-26-19(14)35-4/h7-11,13,15H,5-6H2,1-4H3,(H,28,29)/t10-,11-,13+,15-/m0/s1
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n/an/an/an/a 46n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499567
PNG
(US11020395, Example 164.0 | US11020395, Example 16...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2C[C@H](Cl)C2)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C20H24Cl2N8O5S/c1-10(15(33-2)16-23-7-13(22)8-24-16)36(31,32)29-20-28-27-17(11-5-12(21)6-11)30(20)14-18(34-3)25-9-26-19(14)35-4/h7-12,15H,5-6H2,1-4H3,(H,28,29)/t10-,11-,12+,15-/m0/s1
PDB

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n/an/an/an/a 0.540n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499567
PNG
(US11020395, Example 164.0 | US11020395, Example 16...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2C[C@H](Cl)C2)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C20H24Cl2N8O5S/c1-10(15(33-2)16-23-7-13(22)8-24-16)36(31,32)29-20-28-27-17(11-5-12(21)6-11)30(20)14-18(34-3)25-9-26-19(14)35-4/h7-12,15H,5-6H2,1-4H3,(H,28,29)/t10-,11-,12+,15-/m0/s1
PDB

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n/an/an/an/a 9.70n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499581
PNG
(US11020395, Example 177.0 | US11020395, Example 17...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2C[C@H](C2)C(F)(F)F)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C21H24ClF3N8O5S/c1-10(15(36-2)16-26-7-13(22)8-27-16)39(34,35)32-20-31-30-17(11-5-12(6-11)21(23,24)25)33(20)14-18(37-3)28-9-29-19(14)38-4/h7-12,15H,5-6H2,1-4H3,(H,31,32)/t10-,11-,12+,15-/m0/s1
PDB

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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499581
PNG
(US11020395, Example 177.0 | US11020395, Example 17...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2C[C@H](C2)C(F)(F)F)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C21H24ClF3N8O5S/c1-10(15(36-2)16-26-7-13(22)8-27-16)39(34,35)32-20-31-30-17(11-5-12(6-11)21(23,24)25)33(20)14-18(37-3)28-9-29-19(14)38-4/h7-12,15H,5-6H2,1-4H3,(H,31,32)/t10-,11-,12+,15-/m0/s1
PDB

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n/an/an/an/a 6.5n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499583
PNG
(US11020395, Example 179.0 | US11020395, Example 18...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2CC[C@@H]2F)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C20H24ClFN8O5S/c1-10(15(33-2)16-23-7-11(21)8-24-16)36(31,32)29-20-28-27-17(12-5-6-13(12)22)30(20)14-18(34-3)25-9-26-19(14)35-4/h7-10,12-13,15H,5-6H2,1-4H3,(H,28,29)/t10-,12+,13-,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499592
PNG
(US11020395, Example 186.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2C[C@H](C)C2)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C21H27ClN8O5S/c1-11-6-13(7-11)18-27-28-21(30(18)15-19(34-4)25-10-26-20(15)35-5)29-36(31,32)12(2)16(33-3)17-23-8-14(22)9-24-17/h8-13,16H,6-7H2,1-5H3,(H,28,29)/t11-,12-,13+,16-/m0/s1
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n/an/an/an/a 0.890n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499593
PNG
(US11020395, Example 187.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CC[C@@H]2C)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C21H27ClN8O5S/c1-11-6-7-14(11)18-27-28-21(30(18)15-19(34-4)25-10-26-20(15)35-5)29-36(31,32)12(2)16(33-3)17-23-8-13(22)9-24-17/h8-12,14,16H,6-7H2,1-5H3,(H,28,29)/t11-,12-,14-,16-/m0/s1
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n/an/an/an/a 8.80n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499595
PNG
(US11020395, Example 191.0 | US11020395, Example 19...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2C[C@H](Cl)C2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C23H29ClN6O5S/c1-13-11-25-21(26-12-13)20(35-5)14(2)36(31,32)29-23-28-27-22(15-9-16(24)10-15)30(23)19-17(33-3)7-6-8-18(19)34-4/h6-8,11-12,14-16,20H,9-10H2,1-5H3,(H,28,29)/t14-,15-,16-,20-/m0/s1
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n/an/an/an/a 7.5n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499597
PNG
(US11020395, Example 193.0 | US11020395, Example 19...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1[C@H]1C[C@H](Cl)C1
Show InChI InChI=1S/C23H29ClN6O4S/c1-13-11-25-21(26-12-13)14(2)15(3)35(31,32)29-23-28-27-22(16-9-17(24)10-16)30(23)20-18(33-4)7-6-8-19(20)34-5/h6-8,11-12,14-17H,9-10H2,1-5H3,(H,28,29)/t14-,15-,16-,17-/m0/s1
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n/an/an/an/a 10n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499600
PNG
(US11020395, Example 196.0 | US11020395, Example 19...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CC(=O)C2(C)C)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C24H29ClN6O6S/c1-13(20(37-6)21-26-11-14(25)12-27-21)38(33,34)30-23-29-28-22(15-10-18(32)24(15,2)3)31(23)19-16(35-4)8-7-9-17(19)36-5/h7-9,11-13,15,20H,10H2,1-6H3,(H,29,30)/t13-,15+,20-/m0/s1
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n/an/an/an/a 870n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499612
PNG
(US11020395, Example 210.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)CCc2ncc(Cl)cn2)nnc1C1CCC1
Show InChI InChI=1S/C20H23ClN6O4S/c1-30-15-7-4-8-16(31-2)18(15)27-19(13-5-3-6-13)24-25-20(27)26-32(28,29)10-9-17-22-11-14(21)12-23-17/h4,7-8,11-13H,3,5-6,9-10H2,1-2H3,(H,25,26)
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499613
PNG
(US11020395, Example 211.0)
Show SMILES CC(C)O[C@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CCC2)n1C1CCOCC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C21H31ClN6O4S/c1-13(2)32-18(19-23-11-16(22)12-24-19)14(3)33(29,30)27-21-26-25-20(15-5-4-6-15)28(21)17-7-9-31-10-8-17/h11-15,17-18H,4-10H2,1-3H3,(H,26,27)/t14-,18+/m0/s1
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n/an/an/an/a 420n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499614
PNG
(US11020395, Example 214.0 | US11020395, Example 21...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CC[C@H](C2)OC)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C24H31ClN6O6S/c1-14(21(37-5)22-26-12-16(25)13-27-22)38(32,33)30-24-29-28-23(15-9-10-17(11-15)34-2)31(24)20-18(35-3)7-6-8-19(20)36-4/h6-8,12-15,17,21H,9-11H2,1-5H3,(H,29,30)/t14-,15?,17+,21-/m0/s1
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n/an/an/an/a 15n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499622
PNG
(US11020395, Example 222.0 | US11020395, Example 22...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CC22CC2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C23H27ClN6O5S/c1-13(19(35-4)20-25-11-14(24)12-26-20)36(31,32)29-22-28-27-21(15-10-23(15)8-9-23)30(22)18-16(33-2)6-5-7-17(18)34-3/h5-7,11-13,15,19H,8-10H2,1-4H3,(H,28,29)/t13-,15+,19-/m0/s1
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n/an/an/an/a 24n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499627
PNG
(US11020395, Example 226.0 | US11020395, Example 22...)
Show SMILES CO[C@H]1C[C@H](C1)c1nnc(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C26H36N6O6S/c1-15(2)38-23(24-27-13-16(3)14-28-24)17(4)39(33,34)31-26-30-29-25(18-11-19(12-18)35-5)32(26)22-20(36-6)9-8-10-21(22)37-7/h8-10,13-15,17-19,23H,11-12H2,1-7H3,(H,30,31)/t17-,18-,19+,23+/m0/s1
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n/an/an/an/a 2.70n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499631
PNG
(US11020395, Example 229.0 | US11020395, Example 23...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1[C@@H]1CCC(=O)C1
Show InChI InChI=1S/C26H34N6O6S/c1-15(2)38-23(24-27-13-16(3)14-28-24)17(4)39(34,35)31-26-30-29-25(18-10-11-19(33)12-18)32(26)22-20(36-5)8-7-9-21(22)37-6/h7-9,13-15,17-18,23H,10-12H2,1-6H3,(H,30,31)/t17-,18+,23+/m0/s1
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n/an/an/an/a 30n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499631
PNG
(US11020395, Example 229.0 | US11020395, Example 23...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1[C@@H]1CCC(=O)C1
Show InChI InChI=1S/C26H34N6O6S/c1-15(2)38-23(24-27-13-16(3)14-28-24)17(4)39(34,35)31-26-30-29-25(18-10-11-19(33)12-18)32(26)22-20(36-5)8-7-9-21(22)37-6/h7-9,13-15,17-18,23H,10-12H2,1-6H3,(H,30,31)/t17-,18+,23+/m0/s1
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n/an/an/an/a 190n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM499635
PNG
(US11020395, Example 233.0 | US11020395, Example 23...)
Show SMILES CO[C@H]1CCC[C@H]1c1nnc(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C27H38N6O6S/c1-16(2)39-24(25-28-14-17(3)15-29-25)18(4)40(34,35)32-27-31-30-26(19-10-8-11-20(19)36-5)33(27)23-21(37-6)12-9-13-22(23)38-7/h9,12-16,18-20,24H,8,10-11H2,1-7H3,(H,31,32)/t18-,19+,20-,24+/m0/s1
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n/an/an/an/a 94n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11020395 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%