BindingDB logo
myBDB logout

Patent code US11021467

Compile Data Set for Download or QSAR

Found 405 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500199
PNG
(US11021467, Compound 56)
Show SMILES Nc1nc(N)c(C#N)c(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2CCCNC2CCC(F)(F)CC2)n1
Show InChI InChI=1S/C26H30ClF2N9O/c27-17-3-1-4-18-19(17)24(39)38(12-2-11-33-15-7-9-26(28,29)10-8-15)23(34-18)20(14-5-6-14)35-22-16(13-30)21(31)36-25(32)37-22/h1,3-4,14-15,20,33H,2,5-12H2,(H5,31,32,35,36,37)/t20-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 0.400n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500197
PNG
(US11021467, Compound 54)
Show SMILES Nc1nc(N)c(C#N)c(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2CCCNC2CCC2)n1
Show InChI InChI=1S/C24H28ClN9O/c25-16-6-2-7-17-18(16)23(35)34(11-3-10-29-14-4-1-5-14)22(30-17)19(13-8-9-13)31-21-15(12-26)20(27)32-24(28)33-21/h2,6-7,13-14,19,29H,1,3-5,8-11H2,(H5,27,28,31,32,33)/t19-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 0.400n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500198
PNG
(US11021467, Compound 55)
Show SMILES Nc1nc(N)c(C#N)c(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2CCCNC2COC2)n1
Show InChI InChI=1S/C23H26ClN9O2/c24-15-3-1-4-16-17(15)22(34)33(8-2-7-28-13-10-35-11-13)21(29-16)18(12-5-6-12)30-20-14(9-25)19(26)31-23(27)32-20/h1,3-4,12-13,18,28H,2,5-8,10-11H2,(H5,26,27,30,31,32)/t18-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 0.5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500263
PNG
(US11021467, Compound 122)
Show SMILES CS(=O)(=O)CCCCn1c(nc2cccc(Cl)c2c1=O)[C@@H](Nc1nc(N)nc(N)c1C#N)C1CC1
Show InChI InChI=1S/C22H25ClN8O3S/c1-35(33,34)10-3-2-9-31-20(27-15-6-4-5-14(23)16(15)21(31)32)17(12-7-8-12)28-19-13(11-24)18(25)29-22(26)30-19/h4-6,12,17H,2-3,7-10H2,1H3,(H5,25,26,28,29,30)/t17-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 0.700n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500255
PNG
(US11021467, Compound 114)
Show SMILES Nc1nc(N)c(C#N)c(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2CCCCC#N)n1
Show InChI InChI=1S/C22H22ClN9O/c23-14-5-4-6-15-16(14)21(33)32(10-3-1-2-9-24)20(28-15)17(12-7-8-12)29-19-13(11-25)18(26)30-22(27)31-19/h4-6,12,17H,1-3,7-8,10H2,(H5,26,27,29,30,31)/t17-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 0.800n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500267
PNG
(US11021467, Compound 126)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1C[C@@H]1CCNC1
Show InChI InChI=1S/C20H22ClN9O/c1-10(26-17-12(7-22)16(23)28-20(24)29-17)18-27-14-4-2-3-13(21)15(14)19(31)30(18)9-11-5-6-25-8-11/h2-4,10-11,25H,5-6,8-9H2,1H3,(H5,23,24,26,28,29)/t10-,11+/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 0.900n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500215
PNG
(US11021467, Compound 74)
Show SMILES CC(C)NCC(O)CCn1c(nc2cccc(Cl)c2c1=O)[C@H](C)Nc1nc(N)nc(N)c1C#N
Show InChI InChI=1S/C22H28ClN9O2/c1-11(2)27-10-13(33)7-8-32-20(29-16-6-4-5-15(23)17(16)21(32)34)12(3)28-19-14(9-24)18(25)30-22(26)31-19/h4-6,11-13,27,33H,7-8,10H2,1-3H3,(H5,25,26,28,30,31)/t12-,13?/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500192
PNG
(US11021467, Compound 49)
Show SMILES Cc1nc(N)nc(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2CCCN)c1C#N
Show InChI InChI=1S/C21H23ClN8O/c1-11-13(10-24)18(29-21(25)26-11)28-17(12-6-7-12)19-27-15-5-2-4-14(22)16(15)20(31)30(19)9-3-8-23/h2,4-5,12,17H,3,6-9,23H2,1H3,(H3,25,26,28,29)/t17-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500216
PNG
(US11021467, Compound 75)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1CCC(O)CNC(C)(C)C
Show InChI InChI=1S/C23H30ClN9O2/c1-12(29-19-14(10-25)18(26)31-22(27)32-19)20-30-16-7-5-6-15(24)17(16)21(35)33(20)9-8-13(34)11-28-23(2,3)4/h5-7,12-13,28,34H,8-9,11H2,1-4H3,(H5,26,27,29,31,32)/t12-,13?/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM500192
PNG
(US11021467, Compound 49)
Show SMILES Cc1nc(N)nc(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2CCCN)c1C#N
Show InChI InChI=1S/C21H23ClN8O/c1-11-13(10-24)18(29-21(25)26-11)28-17(12-6-7-12)19-27-15-5-2-4-14(22)16(15)20(31)30(19)9-3-8-23/h2,4-5,12,17H,3,6-9,23H2,1H3,(H3,25,26,28,29)/t17-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500208
PNG
(US11021467, Compound 65)
Show SMILES NC(=O)CCCn1c(nc2c(Cl)ccc(Cl)c2c1=O)[C@@H](Nc1nc(N)nc(N)c1C#N)C1CC1
Show InChI InChI=1S/C21H21Cl2N9O2/c22-11-5-6-12(23)16-14(11)20(34)32(7-1-2-13(25)33)19(29-16)15(9-3-4-9)28-18-10(8-24)17(26)30-21(27)31-18/h5-6,9,15H,1-4,7H2,(H2,25,33)(H5,26,27,28,30,31)/t15-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500254
PNG
(US11021467, Compound 113)
Show SMILES Nc1nc(N)c(C#N)c(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2CCCC#N)n1
Show InChI InChI=1S/C21H20ClN9O/c22-13-4-3-5-14-15(13)20(32)31(9-2-1-8-23)19(27-14)16(11-6-7-11)28-18-12(10-24)17(25)29-21(26)30-18/h3-5,11,16H,1-2,6-7,9H2,(H5,25,26,28,29,30)/t16-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500207
PNG
(US11021467, Compound 64)
Show SMILES NC(=O)CCCCn1c(nc2cccc(Cl)c2c1=O)[C@@H](Nc1nc(N)nc(N)c1C#N)C1CC1
Show InChI InChI=1S/C22H24ClN9O2/c23-13-4-3-5-14-16(13)21(34)32(9-2-1-6-15(25)33)20(28-14)17(11-7-8-11)29-19-12(10-24)18(26)30-22(27)31-19/h3-5,11,17H,1-2,6-9H2,(H2,25,33)(H5,26,27,29,30,31)/t17-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500209
PNG
(US11021467, Compound 66)
Show SMILES NC(=O)CCCn1c(nc2cccc(Cl)c2c1=O)[C@@H](Nc1nc(N)nc(N)c1C#N)C1CC1
Show InChI InChI=1S/C21H22ClN9O2/c22-12-3-1-4-13-15(12)20(33)31(8-2-5-14(24)32)19(27-13)16(10-6-7-10)28-18-11(9-23)17(25)29-21(26)30-18/h1,3-4,10,16H,2,5-8H2,(H2,24,32)(H5,25,26,28,29,30)/t16-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500234
PNG
(US11021467, Compound 93)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1[C@@H]1C[C@H](O)C1
Show InChI InChI=1S/C19H19ClN8O2/c1-8(24-16-11(7-21)15(22)26-19(23)27-16)17-25-13-4-2-3-12(20)14(13)18(30)28(17)9-5-10(29)6-9/h2-4,8-10,29H,5-6H2,1H3,(H5,22,23,24,26,27)/t8-,9-,10+/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500185
PNG
(US11021467, Compound 42)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1CCCN
Show InChI InChI=1S/C18H20ClN9O/c1-9(24-15-10(8-21)14(22)26-18(23)27-15)16-25-12-5-2-4-11(19)13(12)17(29)28(16)7-3-6-20/h2,4-5,9H,3,6-7,20H2,1H3,(H5,22,23,24,26,27)/t9-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500273
PNG
(US11021467, Compound 132)
Show SMILES COC[C@H](C)n1c(nc2cccc(Cl)c2c1=O)[C@H](C)Nc1nc(N)nc(N)c1C#N
Show InChI InChI=1S/C19H21ClN8O2/c1-9(8-30-3)28-17(25-13-6-4-5-12(20)14(13)18(28)29)10(2)24-16-11(7-21)15(22)26-19(23)27-16/h4-6,9-10H,8H2,1-3H3,(H5,22,23,24,26,27)/t9-,10-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500265
PNG
(US11021467, Compound 124)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1C[C@@H]1CCCNC1
Show InChI InChI=1S/C21H24ClN9O/c1-11(27-18-13(8-23)17(24)29-21(25)30-18)19-28-15-6-2-5-14(22)16(15)20(32)31(19)10-12-4-3-7-26-9-12/h2,5-6,11-12,26H,3-4,7,9-10H2,1H3,(H5,24,25,27,29,30)/t11-,12+/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500260
PNG
(US11021467, Compound 119)
Show SMILES CS(=O)(=O)CCCn1c(nc2c(Cl)ccc(Cl)c2c1=O)[C@@H](Nc1nc(N)nc(N)c1C#N)C1CC1
Show InChI InChI=1S/C21H22Cl2N8O3S/c1-35(33,34)8-2-7-31-19(28-16-13(23)6-5-12(22)14(16)20(31)32)15(10-3-4-10)27-18-11(9-24)17(25)29-21(26)30-18/h5-6,10,15H,2-4,7-8H2,1H3,(H5,25,26,27,29,30)/t15-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500259
PNG
(US11021467, Compound 118)
Show SMILES CS(=O)(=O)CCCn1c(nc2cccc(Cl)c2c1=O)[C@@H](Nc1nc(N)nc(N)c1C#N)C1CC1
Show InChI InChI=1S/C21H23ClN8O3S/c1-34(32,33)9-3-8-30-19(26-14-5-2-4-13(22)15(14)20(30)31)16(11-6-7-11)27-18-12(10-23)17(24)28-21(25)29-18/h2,4-5,11,16H,3,6-9H2,1H3,(H5,24,25,27,28,29)/t16-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500262
PNG
(US11021467, Compound 121)
Show SMILES NC(=O)CCCn1c(nc2c(Cl)cc(F)cc2c1=O)[C@@H](Nc1nc(N)nc(N)c1C#N)C1CC1
Show InChI InChI=1S/C21H21ClFN9O2/c22-13-7-10(23)6-11-16(13)29-19(32(20(11)34)5-1-2-14(25)33)15(9-3-4-9)28-18-12(8-24)17(26)30-21(27)31-18/h6-7,9,15H,1-5H2,(H2,25,33)(H5,26,27,28,30,31)/t15-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500220
PNG
(US11021467, Compound 79)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1Cc1cn[nH]c1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500206
PNG
(US11021467, Compound 63)
Show SMILES Nc1nc(N)c(Cl)c(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2CCC#N)n1
Show InChI InChI=1S/C19H18Cl2N8O/c20-10-3-1-4-11-12(10)18(30)29(8-2-7-22)17(25-11)14(9-5-6-9)26-16-13(21)15(23)27-19(24)28-16/h1,3-4,9,14H,2,5-6,8H2,(H5,23,24,26,27,28)/t14-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500160
PNG
(US11021467, Compound 14 | US11021467, Compound 15)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N(C)CCN
Show InChI InChI=1S/C18H21ClN10O/c1-9(24-15-10(8-21)14(22)26-18(23)27-15)16-25-12-5-3-4-11(19)13(12)17(30)29(16)28(2)7-6-20/h3-5,9H,6-7,20H2,1-2H3,(H5,22,23,24,26,27)/t9-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500243
PNG
(US11021467, Compound 102)
Show SMILES Nc1nc(N)c(C#N)c(N[C@@H](C2CC2)c2nc3c(Cl)cc(F)cc3c(=O)n2[C@@H]2C[C@H](O)C2)n1
Show InChI InChI=1S/C21H20ClFN8O2/c22-14-4-9(23)3-12-16(14)28-19(31(20(12)33)10-5-11(32)6-10)15(8-1-2-8)27-18-13(7-24)17(25)29-21(26)30-18/h3-4,8,10-11,15,32H,1-2,5-6H2,(H5,25,26,27,29,30)/t10-,11+,15-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500217
PNG
(US11021467, Compound 76)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1Cc1cc[nH]n1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500211
PNG
(US11021467, Compound 69)
Show SMILES NC(=O)CCCn1c(nc2cccc(Cl)c2c1=O)[C@@H](Nc1nc(N)nc(N)c1Cl)C1CC1
Show InChI InChI=1S/C20H22Cl2N8O2/c21-10-3-1-4-11-13(10)19(32)30(8-2-5-12(23)31)18(26-11)15(9-6-7-9)27-17-14(22)16(24)28-20(25)29-17/h1,3-4,9,15H,2,5-8H2,(H2,23,31)(H5,24,25,27,28,29)/t15-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500196
PNG
(US11021467, Compound 53)
Show SMILES CC(=O)NCCCn1c(nc2cccc(Cl)c2c1=O)[C@@H](Nc1nc(N)nc(N)c1C#N)C1CC1
Show InChI InChI=1S/C22H24ClN9O2/c1-11(33)27-8-3-9-32-20(28-15-5-2-4-14(23)16(15)21(32)34)17(12-6-7-12)29-19-13(10-24)18(25)30-22(26)31-19/h2,4-5,12,17H,3,6-9H2,1H3,(H,27,33)(H5,25,26,29,30,31)/t17-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM500160
PNG
(US11021467, Compound 14 | US11021467, Compound 15)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N(C)CCN
Show InChI InChI=1S/C18H21ClN10O/c1-9(24-15-10(8-21)14(22)26-18(23)27-15)16-25-12-5-3-4-11(19)13(12)17(30)29(16)28(2)7-6-20/h3-5,9H,6-7,20H2,1-2H3,(H5,22,23,24,26,27)/t9-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500270
PNG
(US11021467, Compound 129)
Show SMILES COC(C)(C)CCn1c(nc2cccc(Cl)c2c1=O)[C@H](C)Nc1nc(N)nc(N)c1C#N
Show InChI InChI=1S/C21H25ClN8O2/c1-11(26-17-12(10-23)16(24)28-20(25)29-17)18-27-14-7-5-6-13(22)15(14)19(31)30(18)9-8-21(2,3)32-4/h5-7,11H,8-9H2,1-4H3,(H5,24,25,26,28,29)/t11-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500268
PNG
(US11021467, Compound 127)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1CCCN1CCOCC1
Show InChI InChI=1S/C22H26ClN9O2/c1-13(27-19-14(12-24)18(25)29-22(26)30-19)20-28-16-5-2-4-15(23)17(16)21(33)32(20)7-3-6-31-8-10-34-11-9-31/h2,4-5,13H,3,6-11H2,1H3,(H5,25,26,27,29,30)/t13-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500237
PNG
(US11021467, Compound 96)
Show SMILES Nc1nc(N)c(C#N)c(N[C@@H](C2CC2)c2nc3c(Cl)ccc(Cl)c3c(=O)n2[C@@H]2C[C@H](O)C2)n1
Show InChI InChI=1S/C21H20Cl2N8O2/c22-12-3-4-13(23)16-14(12)20(33)31(9-5-10(32)6-9)19(28-16)15(8-1-2-8)27-18-11(7-24)17(25)29-21(26)30-18/h3-4,8-10,15,32H,1-2,5-6H2,(H5,25,26,27,29,30)/t9-,10+,15-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500241
PNG
(US11021467, Compound 100)
Show SMILES Nc1nc(N)c(C#N)c(N[C@@H](C2CC2)c2nc3c(Cl)ccc(Cl)c3c(=O)n2[C@H]2C[C@H](O)C2)n1
Show InChI InChI=1S/C21H20Cl2N8O2/c22-12-3-4-13(23)16-14(12)20(33)31(9-5-10(32)6-9)19(28-16)15(8-1-2-8)27-18-11(7-24)17(25)29-21(26)30-18/h3-4,8-10,15,32H,1-2,5-6H2,(H5,25,26,27,29,30)/t9-,10-,15-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500171
PNG
(US11021467, Compound 28)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1CCCCN
Show InChI InChI=1S/C19H21ClN8O/c1-11(26-17-12(9-22)16(23)24-10-25-17)18-27-14-6-4-5-13(20)15(14)19(29)28(18)8-3-2-7-21/h4-6,10-11H,2-3,7-8,21H2,1H3,(H3,23,24,25,26)/t11-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500184
PNG
(US11021467, Compound 41)
Show SMILES CNCCCn1c(nc2cccc(Cl)c2c1=O)[C@H](C)Nc1nc(N)nc(C)c1C#N
Show InChI InChI=1S/C20H23ClN8O/c1-11-13(10-22)17(28-20(23)26-11)25-12(2)18-27-15-7-4-6-14(21)16(15)19(30)29(18)9-5-8-24-3/h4,6-7,12,24H,5,8-9H2,1-3H3,(H3,23,25,26,28)/t12-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500264
PNG
(US11021467, Compound 123)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1C[C@H]1CCCNC1
Show InChI InChI=1S/C21H24ClN9O/c1-11(27-18-13(8-23)17(24)29-21(25)30-18)19-28-15-6-2-5-14(22)16(15)20(32)31(19)10-12-4-3-7-26-9-12/h2,5-6,11-12,26H,3-4,7,9-10H2,1H3,(H5,24,25,27,29,30)/t11-,12-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500190
PNG
(US11021467, Compound 47)
Show SMILES NCCCn1c(nc2cccc(Cl)c2c1=O)[C@@H](Nc1nc(N)nc(N)c1C#N)C1CC1
Show InChI InChI=1S/C20H22ClN9O/c21-12-3-1-4-13-14(12)19(31)30(8-2-7-22)18(26-13)15(10-5-6-10)27-17-11(9-23)16(24)28-20(25)29-17/h1,3-4,10,15H,2,5-8,22H2,(H5,24,25,27,28,29)/t15-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500189
PNG
(US11021467, Compound 46)
Show SMILES CNCCCn1c(nc2cccc(Cl)c2c1=O)[C@@H](Nc1nc(N)nc(N)c1C#N)C1CC1
Show InChI InChI=1S/C21H24ClN9O/c1-26-8-3-9-31-19(27-14-5-2-4-13(22)15(14)20(31)32)16(11-6-7-11)28-18-12(10-23)17(24)29-21(25)30-18/h2,4-5,11,16,26H,3,6-9H2,1H3,(H5,24,25,28,29,30)/t16-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500182
PNG
(US11021467, Compound 39)
Show SMILES CNCCCn1c(nc2cccc(Cl)c2c1=O)[C@H](C)Nc1nc(N)nc(N)c1C#N
Show InChI InChI=1S/C19H22ClN9O/c1-10(25-16-11(9-21)15(22)27-19(23)28-16)17-26-13-6-3-5-12(20)14(13)18(30)29(17)8-4-7-24-2/h3,5-6,10,24H,4,7-8H2,1-2H3,(H5,22,23,25,27,28)/t10-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500248
PNG
(US11021467, Compound 107)
Show SMILES COCCCn1c(nc2c(Cl)ccc(Cl)c2c1=O)[C@H](C)Nc1nc(N)nc(N)c1C#N
Show InChI InChI=1S/C19H20Cl2N8O2/c1-9(25-16-10(8-22)15(23)27-19(24)28-16)17-26-14-12(21)5-4-11(20)13(14)18(30)29(17)6-3-7-31-2/h4-5,9H,3,6-7H2,1-2H3,(H5,23,24,25,27,28)/t9-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500226
PNG
(US11021467, Compound 85)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C21H22ClN7O2/c1-11(27-19-14(9-23)18(24)25-10-26-19)20-28-16-4-2-3-15(22)17(16)21(31)29(20)12-5-7-13(30)8-6-12/h2-4,10-13,30H,5-8H2,1H3,(H3,24,25,26,27)/t11-,12-,13-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500253
PNG
(US11021467, Compound 112)
Show SMILES Nc1nc(N)c(C#N)c(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2CCC#N)n1
Show InChI InChI=1S/C20H18ClN9O/c21-12-3-1-4-13-14(12)19(31)30(8-2-7-22)18(26-13)15(10-5-6-10)27-17-11(9-23)16(24)28-20(25)29-17/h1,3-4,10,15H,2,5-6,8H2,(H5,24,25,27,28,29)/t15-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500252
PNG
(US11021467, Compound 111)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1CCCS(C)(=O)=O
Show InChI InChI=1S/C19H21ClN8O3S/c1-10(24-16-11(9-21)15(22)26-19(23)27-16)17-25-13-6-3-5-12(20)14(13)18(29)28(17)7-4-8-32(2,30)31/h3,5-6,10H,4,7-8H2,1-2H3,(H5,22,23,24,26,27)/t10-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500160
PNG
(US11021467, Compound 14 | US11021467, Compound 15)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N(C)CCN
Show InChI InChI=1S/C18H21ClN10O/c1-9(24-15-10(8-21)14(22)26-18(23)27-15)16-25-12-5-3-4-11(19)13(12)17(30)29(16)28(2)7-6-20/h3-5,9H,6-7,20H2,1-2H3,(H5,22,23,24,26,27)/t9-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500271
PNG
(US11021467, Compound 130)
Show SMILES CCOCCn1c(nc2cccc(Cl)c2c1=O)[C@H](C)Nc1nc(N)nc(N)c1C#N
Show InChI InChI=1S/C19H21ClN8O2/c1-3-30-8-7-28-17(25-13-6-4-5-12(20)14(13)18(28)29)10(2)24-16-11(9-21)15(22)26-19(23)27-16/h4-6,10H,3,7-8H2,1-2H3,(H5,22,23,24,26,27)/t10-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500230
PNG
(US11021467, Compound 89)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1CC1CCNC1
Show InChI InChI=1S/C20H21ClN8O/c1-11(27-18-13(7-22)17(23)25-10-26-18)19-28-15-4-2-3-14(21)16(15)20(30)29(19)9-12-5-6-24-8-12/h2-4,10-12,24H,5-6,8-9H2,1H3,(H3,23,25,26,27)/t11-,12?/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500266
PNG
(US11021467, Compound 125)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1C[C@H]1CCNC1
Show InChI InChI=1S/C20H22ClN9O/c1-10(26-17-12(7-22)16(23)28-20(24)29-17)18-27-14-4-2-3-13(21)15(14)19(31)30(18)9-11-5-6-25-8-11/h2-4,10-11,25H,5-6,8-9H2,1H3,(H5,23,24,26,28,29)/t10-,11-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500188
PNG
(US11021467, Compound 45)
Show SMILES NCCCn1c(nc2cccc(Cl)c2c1=O)[C@@H](Nc1ncnc2scnc12)C1CC1
Show InChI InChI=1S/C20H20ClN7OS/c21-12-3-1-4-13-14(12)20(29)28(8-2-7-22)18(26-13)15(11-5-6-11)27-17-16-19(24-9-23-17)30-10-25-16/h1,3-4,9-11,15H,2,5-8,22H2,(H,23,24,27)/t15-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM500194
PNG
(US11021467, Compound 52)
Show SMILES CC(C)(C)C(=O)NCCCn1c(nc2cccc(Cl)c2c1=O)[C@@H](Nc1nc(N)nc(N)c1C#N)C1CC1
Show InChI InChI=1S/C25H30ClN9O2/c1-25(2,3)23(37)30-10-5-11-35-21(31-16-7-4-6-15(26)17(16)22(35)36)18(13-8-9-13)32-20-14(12-27)19(28)33-24(29)34-20/h4,6-7,13,18H,5,8-11H2,1-3H3,(H,30,37)(H5,28,29,32,33,34)/t18-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (Human))
BDBM500199
PNG
(US11021467, Compound 56)
Show SMILES Nc1nc(N)c(C#N)c(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2CCCNC2CCC(F)(F)CC2)n1
Show InChI InChI=1S/C26H30ClF2N9O/c27-17-3-1-4-18-19(17)24(39)38(12-2-11-33-15-7-9-26(28,29)10-8-15)23(34-18)20(14-5-6-14)35-22-16(13-30)21(31)36-25(32)37-22/h1,3-4,14-15,20,33H,2,5-12H2,(H5,31,32,35,36,37)/t20-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...


US Patent US11021467 (2021)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 405 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%