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Patent code US11021481

Compile Data Set for Download or QSAR

Found 837 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501020
PNG
((S)-7-((6-(4- amino-2- oxopyrrolidin- 1-yl)pyridin...)
Show SMILES Cn1ccc2c(ccnc12)-c1ncc(Nc2cccc(n2)N2C[C@@H](N)CC2=O)c2C(=O)NCc12
Show InChI InChI=1S/C24H22N8O2/c1-31-8-6-15-14(5-7-26-23(15)31)22-16-10-28-24(34)21(16)17(11-27-22)29-18-3-2-4-19(30-18)32-12-13(25)9-20(32)33/h2-8,11,13H,9-10,12,25H2,1H3,(H,28,34)(H,29,30)/t13-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501058
PNG
((R)-4-(7- fluoroimidazo [1,2-a]pyridin- 3-yl)-7-((...)
Show SMILES CC(C)N(C)Cc1nc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)ccc1[C@@H]1CCOC1
Show InChI InChI=1S/C29H31FN6O2/c1-17(2)35(3)15-24-20(18-9-11-38-16-18)5-7-26(34-24)33-23-6-4-21(22-13-32-29(37)28(22)23)25-14-31-27-12-19(30)8-10-36(25)27/h4-8,10,12,14,17-18H,9,11,13,15-16H2,1-3H3,(H,32,37)(H,33,34)/t18-/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501070
PNG
(4-(7- fluoroimidazo [1,2-a]pyridin- 3-yl)-74(6-(((...)
Show SMILES F[C@@H]1CCN(Cc2nc(Nc3ccc(c4CNC(=O)c34)-c3cnc4cc(F)ccn34)ccc2[C@@H]2CCOC2)C1
Show InChI InChI=1S/C29H28F2N6O2/c30-18-6-9-37-25(13-32-27(37)11-18)21-1-3-23(28-22(21)12-33-29(28)38)34-26-4-2-20(17-7-10-39-16-17)24(35-26)15-36-8-5-19(31)14-36/h1-4,6,9,11,13,17,19H,5,7-8,10,12,14-16H2,(H,33,38)(H,34,35)/t17-,19-/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501073
PNG
((R)-7-((6- ((dimethylamino)- methyl)-5-(3-(2- hydr...)
Show SMILES CN(C)Cc1nc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)ccc1N1CCC[C@@H](C1)C(C)(C)O
Show InChI InChI=1S/C31H36FN7O2/c1-31(2,41)19-6-5-12-38(17-19)25-9-10-27(36-24(25)18-37(3)4)35-23-8-7-21(22-15-34-30(40)29(22)23)26-16-33-28-14-20(32)11-13-39(26)28/h7-11,13-14,16,19,41H,5-6,12,15,17-18H2,1-4H3,(H,34,40)(H,35,36)/t19-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501075
PNG
(4-(7- fluoroimidazo [1,2-a]pyridin- 3-yl)-7-((5-(2...)
Show SMILES CC(C)(N1CCOCC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)nc1
Show InChI InChI=1S/C27H27FN6O2/c1-27(2,33-9-11-36-12-10-33)17-3-6-23(29-14-17)32-21-5-4-19(20-15-31-26(35)25(20)21)22-16-30-24-13-18(28)7-8-34(22)24/h3-8,13-14,16H,9-12,15H2,1-2H3,(H,29,32)(H,31,35)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501097
PNG
((R)-7-((6- ((dimethylamino)- methyl)-5-(2-(2- hydr...)
Show SMILES CN(C)Cc1nc(Nc2cnc(c3CNC(=O)c23)-c2ccnc3n(C)ccc23)ccc1N1CCO[C@@H](C1)C(C)(C)O
Show InChI InChI=1S/C30H36N8O3/c1-30(2,40)24-17-38(12-13-41-24)23-6-7-25(35-22(23)16-36(3)4)34-21-15-32-27(20-14-33-29(39)26(20)21)18-8-10-31-28-19(18)9-11-37(28)5/h6-11,15,24,40H,12-14,16-17H2,1-5H3,(H,33,39)(H,34,35)/t24-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501106
PNG
(4-(7- fluoroimidazo [1,2-a]pyridin- 3-yl)-7-((6-((...)
Show SMILES O[C@H]1CCN(Cc2nc(Nc3ccc(c4CNC(=O)c34)-c3cnc4cc(F)ccn34)ccc2[C@H]2CCOC2)C1
Show InChI InChI=1S/C29H29FN6O3/c30-18-5-9-36-25(13-31-27(36)11-18)21-1-3-23(28-22(21)12-32-29(28)38)33-26-4-2-20(17-7-10-39-16-17)24(34-26)15-35-8-6-19(37)14-35/h1-5,9,11,13,17,19,37H,6-8,10,12,14-16H2,(H,32,38)(H,33,34)/t17-,19-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501110
PNG
(7-((6- ((dimethylamino)- methyl)-5- (4-hydroxy-4- ...)
Show SMILES COCC1(O)CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)nc1CN(C)C
Show InChI InChI=1S/C30H34FN7O3/c1-36(2)17-23-24(37-12-9-30(40,10-13-37)18-41-3)6-7-26(35-23)34-22-5-4-20(21-15-33-29(39)28(21)22)25-16-32-27-14-19(31)8-11-38(25)27/h4-8,11,14,16,40H,9-10,12-13,15,17-18H2,1-3H3,(H,33,39)(H,34,35)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501121
PNG
(7-((6- ((dimethylamino)- methyl)-5- ((lS,3S)-3- me...)
Show SMILES CO[C@@H]1CCC(C1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)nc1CN(C)C
Show InChI InChI=1S/C29H31FN6O2/c1-35(2)16-24-20(17-4-5-19(12-17)38-3)7-9-26(34-24)33-23-8-6-21(22-14-32-29(37)28(22)23)25-15-31-27-13-18(30)10-11-36(25)27/h6-11,13,15,17,19H,4-5,12,14,16H2,1-3H3,(H,32,37)(H,33,34)/t17?,19-/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501122
PNG
(7-((6- ((dimethylamino)- methyl)-5- ((lR,3R)-3- me...)
Show SMILES CO[C@H]1CCC(C1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)nc1CN(C)C
Show InChI InChI=1S/C29H31FN6O2/c1-35(2)16-24-20(17-4-5-19(12-17)38-3)7-9-26(34-24)33-23-8-6-21(22-14-32-29(37)28(22)23)25-15-31-27-13-18(30)10-11-36(25)27/h6-11,13,15,17,19H,4-5,12,14,16H2,1-3H3,(H,32,37)(H,33,34)/t17?,19-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501123
PNG
(7-((6- ((dimethylamino)- methyl)-5- (4-methyl-3- o...)
Show SMILES CN(C)Cc1nc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)ccc1N1CCN(C)C(=O)C1
Show InChI InChI=1S/C28H29FN8O2/c1-34(2)15-21-22(36-11-10-35(3)26(38)16-36)6-7-24(33-21)32-20-5-4-18(19-13-31-28(39)27(19)20)23-14-30-25-12-17(29)8-9-37(23)25/h4-9,12,14H,10-11,13,15-16H2,1-3H3,(H,31,39)(H,32,33)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501135
PNG
((R)-7-((6-(2- (dimethylami- no)ethyl)-5- (tetrahyd...)
Show SMILES CN(C)CCc1nc(Nc2cnc(c3CNC(=O)c23)-c2ccnc3n(C)ccc23)ccc1[C@@H]1CCOC1
Show InChI InChI=1S/C28H31N7O2/c1-34(2)11-8-22-18(17-9-13-37-16-17)4-5-24(32-22)33-23-15-30-26(21-14-31-28(36)25(21)23)19-6-10-29-27-20(19)7-12-35(27)3/h4-7,10,12,15,17H,8-9,11,13-14,16H2,1-3H3,(H,31,36)(H,32,33)/t17-/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501145
PNG
(7-((6-((R)-1- (dimethylami- no)ethyl)-5- ((R)-THF-...)
Show SMILES C[C@@H](N(C)C)c1nc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)ccc1[C@H]1CCOC1
Show InChI InChI=1S/C28H29FN6O2/c1-16(34(2)3)27-19(17-9-11-37-15-17)5-7-24(33-27)32-22-6-4-20(21-13-31-28(36)26(21)22)23-14-30-25-12-18(29)8-10-35(23)25/h4-8,10,12,14,16-17H,9,11,13,15H2,1-3H3,(H,31,36)(H,32,33)/t16-,17+/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501157
PNG
((R)-7-((6- (aminomethyl)- 5-(THF-3- yl)pyridin-2- ...)
Show SMILES Cn1ccc2c(ccnc12)-c1ncc(Nc2ccc([C@H]3CCOC3)c(CN)n2)c2C(=O)NCc12
Show InChI InChI=1S/C25H25N7O2/c1-32-8-5-17-16(4-7-27-24(17)32)23-18-11-29-25(33)22(18)20(12-28-23)31-21-3-2-15(19(10-26)30-21)14-6-9-34-13-14/h2-5,7-8,12,14H,6,9-11,13,26H2,1H3,(H,29,33)(H,30,31)/t14-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500363
PNG
(7-[[5-(4- methylpiperazin- 1-yl)-2- pyridyl]amino]...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2c[nH]c3ncccc23)nc1
Show InChI InChI=1S/C25H25N7O/c1-31-9-11-32(12-10-31)16-4-7-22(27-13-16)30-21-6-5-17(20-15-29-25(33)23(20)21)19-14-28-24-18(19)3-2-8-26-24/h2-8,13-14H,9-12,15H2,1H3,(H,26,28)(H,27,30)(H,29,33)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501162
PNG
(7-((6- ((dimethylamino)- methyl)-5-(4- fluorotetra...)
Show SMILES CN(C)Cc1nc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)ccc1C1(F)CCOCC1
Show InChI InChI=1S/C28H28F2N6O2/c1-35(2)16-22-20(28(30)8-11-38-12-9-28)4-6-24(34-22)33-21-5-3-18(19-14-32-27(37)26(19)21)23-15-31-25-13-17(29)7-10-36(23)25/h3-7,10,13,15H,8-9,11-12,14,16H2,1-2H3,(H,32,37)(H,33,34)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501166
PNG
(7-((6-(2- (dimethylami- no)ethyl)-5- (tetrahydro- ...)
Show SMILES CN(C)CCc1nc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)ccc1C1CCOCC1
Show InChI InChI=1S/C29H31FN6O2/c1-35(2)11-8-23-20(18-9-13-38-14-10-18)4-6-26(33-23)34-24-5-3-21(22-16-32-29(37)28(22)24)25-17-31-27-15-19(30)7-12-36(25)27/h3-7,12,15,17-18H,8-11,13-14,16H2,1-2H3,(H,32,37)(H,33,34)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501174
PNG
(7-[[6- [(dimethylamino)- methyl]-5- tetrahydrofura...)
Show SMILES CN(C)Cc1nc(Nc2ccc(c3CNC(=O)c23)-c2cnn3cc(C)cnc23)ccc1C1CCOC1
Show InChI InChI=1S/C27H29N7O2/c1-16-10-28-26-21(12-30-34(26)13-16)19-4-6-22(25-20(19)11-29-27(25)35)31-24-7-5-18(17-8-9-36-15-17)23(32-24)14-33(2)3/h4-7,10,12-13,17H,8-9,11,14-15H2,1-3H3,(H,29,35)(H,31,32)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500399
PNG
(4-imidazo[1,2- a]pyridin-3-yl- 7-[[5-[4- (methylam...)
Show SMILES CNC1CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3ccccn23)nc1
Show InChI InChI=1S/C26H27N7O/c1-27-17-9-12-32(13-10-17)18-5-8-23(28-14-18)31-21-7-6-19(20-15-30-26(34)25(20)21)22-16-29-24-4-2-3-11-33(22)24/h2-8,11,14,16-17,27H,9-10,12-13,15H2,1H3,(H,28,31)(H,30,34)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500405
PNG
(4-(7-methylimidazo [1,2-a]pyridin- 3-yl)-7-[[5-(4-...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(C)ccn23)nc1
Show InChI InChI=1S/C26H27N7O/c1-17-7-8-33-22(16-28-24(33)13-17)19-4-5-21(25-20(19)15-29-26(25)34)30-23-6-3-18(14-27-23)32-11-9-31(2)10-12-32/h3-8,13-14,16H,9-12,15H2,1-2H3,(H,27,30)(H,29,34)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500416
PNG
(7-[[5-(4- hydroxy-1- piperidyl)-2- pyridyl]amino]-...)
Show SMILES Cn1ccc2c(ccnc12)-c1ccc(Nc2ccc(cn2)N2CCC(O)CC2)c2C(=O)NCc12
Show InChI InChI=1S/C26H26N6O2/c1-31-11-9-20-19(6-10-27-25(20)31)18-3-4-22(24-21(18)15-29-26(24)34)30-23-5-2-16(14-28-23)32-12-7-17(33)8-13-32/h2-6,9-11,14,17,33H,7-8,12-13,15H2,1H3,(H,28,30)(H,29,34)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500425
PNG
(4-(7-methylpyrazolo [1,5-a]pyridin-3- yl)-7-[(5- p...)
Show SMILES Cc1cccc2c(cnn12)-c1ccc(Nc2ccc(cn2)N2CCNCC2)c2C(=O)NCc12
Show InChI InChI=1S/C25H25N7O/c1-16-3-2-4-22-19(15-29-32(16)22)18-6-7-21(24-20(18)14-28-25(24)33)30-23-8-5-17(13-27-23)31-11-9-26-10-12-31/h2-8,13,15,26H,9-12,14H2,1H3,(H,27,30)(H,28,33)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500428
PNG
(4-imidazo[1,2- a]pyrimidin-3- yl-7-[(5- piperazin-...)
Show SMILES O=C1NCc2c1c(Nc1ccc(cn1)N1CCNCC1)ccc2-c1cnc2ncccn12
Show InChI InChI=1S/C23H22N8O/c32-22-21-17(13-27-22)16(19-14-28-23-25-6-1-9-31(19)23)3-4-18(21)29-20-5-2-15(12-26-20)30-10-7-24-8-11-30/h1-6,9,12,14,24H,7-8,10-11,13H2,(H,26,29)(H,27,32)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500429
PNG
(4-(8-fluoroimidazo [1,2-a]pyridin- 3-yl)-7-[(5- pi...)
Show SMILES Fc1cccn2c(cnc12)-c1ccc(Nc2ccc(cn2)N2CCNCC2)c2C(=O)NCc12
Show InChI InChI=1S/C24H22FN7O/c25-18-2-1-9-32-20(14-28-23(18)32)16-4-5-19(22-17(16)13-29-24(22)33)30-21-6-3-15(12-27-21)31-10-7-26-8-11-31/h1-6,9,12,14,26H,7-8,10-11,13H2,(H,27,30)(H,29,33)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500385
PNG
(4-(1-methylpyrrolo] 2,3-b]pyridin- 4-yl)-7-[(5- pi...)
Show SMILES Cn1ccc2c(ccnc12)-c1ccc(Nc2ccc(cn2)N2CCNCC2)c2C(=O)NCc12
Show InChI InChI=1S/C25H25N7O/c1-31-11-7-19-18(6-8-27-24(19)31)17-3-4-21(23-20(17)15-29-25(23)33)30-22-5-2-16(14-28-22)32-12-9-26-10-13-32/h2-8,11,14,26H,9-10,12-13,15H2,1H3,(H,28,30)(H,29,33)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500441
PNG
(7-[[5-[(3R)-3- (methv iamino)- 1-piperidyl]- 2-pyr...)
Show SMILES CN[C@@H]1CCCN(C1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2ccnc3n(C)ccc23)nc1
Show InChI InChI=1S/C27H29N7O/c1-28-17-4-3-12-34(16-17)18-5-8-24(30-14-18)32-23-7-6-19(22-15-31-27(35)25(22)23)20-9-11-29-26-21(20)10-13-33(26)2/h5-11,13-14,17,28H,3-4,12,15-16H2,1-2H3,(H,30,32)(H,31,35)/t17-/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500489
PNG
(4-(7- methylimidazo [1,2-a]pyridin- 3-yl)-7-[(5- m...)
Show SMILES Cc1ccn2c(cnc2c1)-c1ccc(Nc2ccc(cn2)S(C)(=O)=O)c2C(=O)NCc12
Show InChI InChI=1S/C22H19N5O3S/c1-13-7-8-27-18(12-24-20(27)9-13)15-4-5-17(21-16(15)11-25-22(21)28)26-19-6-3-14(10-23-19)31(2,29)30/h3-10,12H,11H2,1-2H3,(H,23,26)(H,25,28)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500496
PNG
(4-(7-methylimidazo [1,2-a]pyridin- 3-yl)-7-[(5- TH...)
Show SMILES Cc1ccn2c(cnc2c1)-c1ccc(Nc2ccc(cn2)C2CCOC2)c2C(=O)NCc12
Show InChI InChI=1S/C25H23N5O2/c1-15-6-8-30-21(13-27-23(30)10-15)18-3-4-20(24-19(18)12-28-25(24)31)29-22-5-2-16(11-26-22)17-7-9-32-14-17/h2-6,8,10-11,13,17H,7,9,12,14H2,1H3,(H,26,29)(H,28,31)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500503
PNG
(7-[[5-(4-hydroxy-1- piperidyl)-2-pyridyl] amino]-4...)
Show SMILES OC1CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cccnn23)nc1
Show InChI InChI=1S/C24H23N7O2/c32-16-7-10-30(11-8-16)15-3-6-21(25-12-15)29-19-5-4-17(18-13-27-24(33)23(18)19)20-14-26-22-2-1-9-28-31(20)22/h1-6,9,12,14,16,32H,7-8,10-11,13H2,(H,25,29)(H,27,33)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500512
PNG
(7-[[5-[(3R)-3- hydroxy-1- piperipyl]-2- pyripyl]am...)
Show SMILES O[C@@H]1CCCN(C1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cnccn23)nc1
Show InChI InChI=1S/C24H23N7O2/c32-16-2-1-8-30(14-16)15-3-6-21(26-10-15)29-19-5-4-17(18-11-28-24(33)23(18)19)20-12-27-22-13-25-7-9-31(20)22/h3-7,9-10,12-13,16,32H,1-2,8,11,14H2,(H,26,29)(H,28,33)/t16-/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500523
PNG
(3-[7-[[5-(4-hydroxy-1- piperidyl)-2-pyridyl] amino...)
Show SMILES OC1CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(ccn23)C#N)nc1
Show InChI InChI=1S/C26H23N7O2/c27-12-16-5-10-33-22(15-29-24(33)11-16)19-2-3-21(25-20(19)14-30-26(25)35)31-23-4-1-17(13-28-23)32-8-6-18(34)7-9-32/h1-5,10-11,13,15,18,34H,6-9,14H2,(H,28,31)(H,30,35)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500531
PNG
(5-chloro-7-[[5-(4- hydroxy-1- piperidyl)-2- pyridy...)
Show SMILES Cn1ccc2c(ccnc12)-c1c2CNC(=O)c2c(Nc2ccc(cn2)N2CCC(O)CC2)cc1Cl
Show InChI InChI=1S/C26H25ClN6O2/c1-32-9-7-18-17(4-8-28-25(18)32)23-19-14-30-26(35)24(19)21(12-20(23)27)31-22-3-2-15(13-29-22)33-10-5-16(34)6-11-33/h2-4,7-9,12-13,16,34H,5-6,10-11,14H2,1H3,(H,29,31)(H,30,35)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500566
PNG
(7-[[5-[(3S)-3- (1-hydroxy-1- methyl-ethyl)- 1-pipe...)
Show SMILES Cc1ccn2c(cnc2n1)-c1ccc(Nc2ccc(cn2)N2CCC[C@@H](C2)C(C)(C)O)c2C(=O)NCc12
Show InChI InChI=1S/C28H31N7O2/c1-17-10-12-35-23(15-31-27(35)32-17)20-7-8-22(25-21(20)14-30-26(25)36)33-24-9-6-19(13-29-24)34-11-4-5-18(16-34)28(2,3)37/h6-10,12-13,15,18,37H,4-5,11,14,16H2,1-3H3,(H,29,33)(H,30,36)/t18-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500572
PNG
(7-[[6-[(3R)-3- amino-1-piperidyl]-2- pyridyl]-amin...)
Show SMILES Cn1ccc2c(ccnc12)-c1ncc(Nc2cccc(n2)N2CCC[C@@H](N)C2)c2C(=O)NCc12
Show InChI InChI=1S/C25H26N8O/c1-32-11-8-17-16(7-9-27-24(17)32)23-18-12-29-25(34)22(18)19(13-28-23)30-20-5-2-6-21(31-20)33-10-3-4-15(26)14-33/h2,5-9,11,13,15H,3-4,10,12,14,26H2,1H3,(H,29,34)(H,30,31)/t15-/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500574
PNG
(7-[[5-[(3R)-3- (1-hydroxy-1- methyl-ethyl)- 1-pipe...)
Show SMILES Cc1ccn2c(cnc2n1)-c1ccc(Nc2ccc(cn2)N2CCC[C@H](C2)C(C)(C)O)c2C(=O)NCc12
Show InChI InChI=1S/C28H31N7O2/c1-17-10-12-35-23(15-31-27(35)32-17)20-7-8-22(25-21(20)14-30-26(25)36)33-24-9-6-19(13-29-24)34-11-4-5-18(16-34)28(2,3)37/h6-10,12-13,15,18,37H,4-5,11,14,16H2,1-3H3,(H,29,33)(H,30,36)/t18-/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500577
PNG
(4-(7-chloroimidazo [1,2-a]pyridin- 3-yl)-7-[[6-(4-...)
Show SMILES CN1CCN(CC1)c1cccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(Cl)ccn23)n1
Show InChI InChI=1S/C25H24ClN7O/c1-31-9-11-32(12-10-31)22-4-2-3-21(30-22)29-19-6-5-17(18-14-28-25(34)24(18)19)20-15-27-23-13-16(26)7-8-33(20)23/h2-8,13,15H,9-12,14H2,1H3,(H,28,34)(H,29,30)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500579
PNG
(4-(7- fluoroimidazo [1,2-a]pyridin- 3-yl)-7-[[5- (...)
Show SMILES Fc1ccn2c(cnc2c1)-c1ccc(Nc2ccc(CN3CCOCC3)cn2)c2C(=O)NCc12
Show InChI InChI=1S/C25H23FN6O2/c26-17-5-6-32-21(14-28-23(32)11-17)18-2-3-20(24-19(18)13-29-25(24)33)30-22-4-1-16(12-27-22)15-31-7-9-34-10-8-31/h1-6,11-12,14H,7-10,13,15H2,(H,27,30)(H,29,33)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500586
PNG
(7-[[6-[(3S)-3- (methylamino) pyrrolidin-1- yl]-2-p...)
Show SMILES CN[C@H]1CCN(C1)c1cccc(Nc2cnc(c3CNC(=O)c23)-c2ccnc3n(C)ccc23)n1
Show InChI InChI=1S/C25H26N8O/c1-26-15-7-11-33(14-15)21-5-3-4-20(31-21)30-19-13-28-23(18-12-29-25(34)22(18)19)16-6-9-27-24-17(16)8-10-32(24)2/h3-6,8-10,13,15,26H,7,11-12,14H2,1-2H3,(H,29,34)(H,30,31)/t15-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500588
PNG
(7-[[6-(4- methylpiperazin- 1-yl)-2- pyridyl]amino]...)
Show SMILES CN1CCN(CC1)c1cccc(Nc2ccc(c3CNC(=O)c23)-c2ccnc3n(C)ccc23)n1
Show InChI InChI=1S/C26H27N7O/c1-31-12-14-33(15-13-31)23-5-3-4-22(30-23)29-21-7-6-17(20-16-28-26(34)24(20)21)18-8-10-27-25-19(18)9-11-32(25)2/h3-11H,12-16H2,1-2H3,(H,28,34)(H,29,30)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500596
PNG
(7-((5-(4- methylpiperazin- 1-yl)pyridin- 2-yl)amin...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2cnc(c3CNC(=O)c23)-c2cnn3CCCCc23)nc1
Show InChI InChI=1S/C24H28N8O/c1-30-8-10-31(11-9-30)16-5-6-21(25-12-16)29-19-15-26-23(18-13-27-24(33)22(18)19)17-14-28-32-7-3-2-4-20(17)32/h5-6,12,14-15H,2-4,7-11,13H2,1H3,(H,25,29)(H,27,33)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500600
PNG
((R)-4-(6- methyl-6,7- dihydro-5H- pyrazolo[5,1- b]...)
Show SMILES C[C@@H]1COc2c(cnn2C1)-c1ccc(Nc2ccc(cn2)N2CCN(C)CC2)c2C(=O)NCc12
Show InChI InChI=1S/C25H29N7O2/c1-16-14-32-25(34-15-16)20(13-28-32)18-4-5-21(23-19(18)12-27-24(23)33)29-22-6-3-17(11-26-22)31-9-7-30(2)8-10-31/h3-6,11,13,16H,7-10,12,14-15H2,1-2H3,(H,26,29)(H,27,33)/t16-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500610
PNG
(2-(4-(7-((5-(4- methylpiperazin- 1-yl)pyridin- 2-y...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2ccnc3n(CC(N)=O)ccc23)nc1
Show InChI InChI=1S/C27H28N8O2/c1-33-10-12-34(13-11-33)17-2-5-24(30-14-17)32-22-4-3-18(21-15-31-27(37)25(21)22)19-6-8-29-26-20(19)7-9-35(26)16-23(28)36/h2-9,14H,10-13,15-16H2,1H3,(H2,28,36)(H,30,32)(H,31,37)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500613
PNG
(4-(1-methyl- 1H-pyrrolo[2,3- b]pyridin-4- yl)-7-((...)
Show SMILES Cn1ccc2c(ccnc12)-c1ccc(Nc2ccc(cn2)C2(C)CCNCC2)c2C(=O)NCc12
Show InChI InChI=1S/C27H28N6O/c1-27(9-12-28-13-10-27)17-3-6-23(30-15-17)32-22-5-4-18(21-16-31-26(34)24(21)22)19-7-11-29-25-20(19)8-14-33(25)2/h3-8,11,14-15,28H,9-10,12-13,16H2,1-2H3,(H,30,32)(H,31,34)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500616
PNG
(7-((5-(1,4- dimethyl-piperidin-4- yl)pyridin-2- yl...)
Show SMILES CN1CCC(C)(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2ccnc3n(C)ccc23)nc1
Show InChI InChI=1S/C28H30N6O/c1-28(10-14-33(2)15-11-28)18-4-7-24(30-16-18)32-23-6-5-19(22-17-31-27(35)25(22)23)20-8-12-29-26-21(20)9-13-34(26)3/h4-9,12-13,16H,10-11,14-15,17H2,1-3H3,(H,30,32)(H,31,35)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500619
PNG
(7-((5-(4-hydroxypi- peridin-1- yl)pyridin-2- yl)am...)
Show SMILES Cn1ccc2c(cccc12)-c1ncc(Nc2ccc(cn2)N2CCC(O)CC2)c2C(=O)NCc12
Show InChI InChI=1S/C26H26N6O2/c1-31-10-9-18-19(3-2-4-22(18)31)25-20-14-29-26(34)24(20)21(15-28-25)30-23-6-5-16(13-27-23)32-11-7-17(33)8-12-32/h2-6,9-10,13,15,17,33H,7-8,11-12,14H2,1H3,(H,27,30)(H,29,34)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500624
PNG
(7-((5-(4-hydroxy- piperidin-1- yl)pyridin-2- yl)am...)
Show SMILES OC1CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnn3CCCCc23)nc1
Show InChI InChI=1S/C25H28N6O2/c32-17-8-11-30(12-9-17)16-4-7-23(26-13-16)29-21-6-5-18(20-14-27-25(33)24(20)21)19-15-28-31-10-2-1-3-22(19)31/h4-7,13,15,17,32H,1-3,8-12,14H2,(H,26,29)(H,27,33)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500634
PNG
(6-methyl-2- ((7-(1-methyl- 1H-pyrrolo[2,3- b]pyrid...)
Show SMILES CN1CCc2cc(Nc3ccc(c4CNC(=O)c34)-c3ccnc4n(C)ccc34)nn2CC1=O
Show InChI InChI=1S/C24H23N7O2/c1-29-9-6-14-11-20(28-31(14)13-21(29)32)27-19-4-3-15(18-12-26-24(33)22(18)19)16-5-8-25-23-17(16)7-10-30(23)2/h3-5,7-8,10-11H,6,9,12-13H2,1-2H3,(H,26,33)(H,27,28)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500690
PNG
(7-((5-((2S,4R)-4- hydroxy-2- methylpiperidin- 1-yl...)
Show SMILES C[C@H]1C[C@H](O)CCN1c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cnccn23)nc1
Show InChI InChI=1S/C25H25N7O2/c1-15-10-17(33)6-8-31(15)16-2-5-22(27-11-16)30-20-4-3-18(19-12-29-25(34)24(19)20)21-13-28-23-14-26-7-9-32(21)23/h2-5,7,9,11,13-15,17,33H,6,8,10,12H2,1H3,(H,27,30)(H,29,34)/t15-,17+/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500694
PNG
(4-(7-fluoroimidazo [1,2-a]pyridin- 3-yl)-7-((5- ((...)
Show SMILES C[C@H](O)[C@H]1CCCN(C1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)nc1
Show InChI InChI=1S/C27H27FN6O2/c1-16(35)17-3-2-9-33(15-17)19-4-7-24(29-12-19)32-22-6-5-20(21-13-31-27(36)26(21)22)23-14-30-25-11-18(28)8-10-34(23)25/h4-8,10-12,14,16-17,35H,2-3,9,13,15H2,1H3,(H,29,32)(H,31,36)/t16-,17-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500695
PNG
(4-(7-fluoroimidazo [1,2-a]pyridin- 3-yl)-7-((5- ((...)
Show SMILES C[C@@H](O)[C@@H]1CCCN(C1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)nc1
Show InChI InChI=1S/C27H27FN6O2/c1-16(35)17-3-2-9-33(15-17)19-4-7-24(29-12-19)32-22-6-5-20(21-13-31-27(36)26(21)22)23-14-30-25-11-18(28)8-10-34(23)25/h4-8,10-12,14,16-17,35H,2-3,9,13,15H2,1H3,(H,29,32)(H,31,36)/t16-,17-/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11021481 (2021)

More data for this
Ligand-Target Pair
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