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Found 20 Enz. Inhib. hit(s) with all data for entry = 9934
TargetStimulator of interferon genes protein [138-378](Mus musculus (Mouse))
Janssen Biotech

US Patent
LigandPNGBDBM501204(US11021511, Compound 4)
Affinity DataIC50: <2nMAssay Description:The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein [139-379,H232R](Homo sapiens (Human))
Janssen Biotech

US Patent
LigandPNGBDBM501364(US11021511, Compound 6c)
Affinity DataIC50: <10nMAssay Description:The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein [138-378](Mus musculus (Mouse))
Janssen Biotech

US Patent
LigandPNGBDBM501363(US11021511, Compound 6b)
Affinity DataIC50: <10nMAssay Description:The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein [139-379,H232R](Homo sapiens (Human))
Janssen Biotech

US Patent
LigandPNGBDBM501362(US11021511, Compound 6a)
Affinity DataIC50: <10nMAssay Description:The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein [139-379,H232R](Homo sapiens (Human))
Janssen Biotech

US Patent
LigandPNGBDBM501361(US11021511, Compound 5)
Affinity DataIC50: <10nMAssay Description:The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein [139-379,H232R](Homo sapiens (Human))
Janssen Biotech

US Patent
LigandPNGBDBM501363(US11021511, Compound 6b)
Affinity DataIC50: <10nMAssay Description:The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein [139-379,H232R](Homo sapiens (Human))
Janssen Biotech

US Patent
LigandPNGBDBM501204(US11021511, Compound 4)
Affinity DataIC50: <10nMAssay Description:The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein [138-378](Mus musculus (Mouse))
Janssen Biotech

US Patent
LigandPNGBDBM501364(US11021511, Compound 6c)
Affinity DataIC50: <10nMAssay Description:The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein [138-378](Mus musculus (Mouse))
Janssen Biotech

US Patent
LigandPNGBDBM501361(US11021511, Compound 5)
Affinity DataIC50:  16nMAssay Description:The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein [139-379,H232R](Homo sapiens (Human))
Janssen Biotech

US Patent
LigandPNGBDBM501193(US11021511, Compound 1)
Affinity DataIC50:  5.45E+4nMAssay Description:The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein [139-379,H232R](Homo sapiens (Human))
Janssen Biotech

US Patent
LigandPNGBDBM501364(US11021511, Compound 6c)
Affinity DataKd:  1.70nMAssay Description:Compounds were analyzed on an S200 biacore SPR instrument (GE Healthcare). E. coli produced truncated STING protein was immobilized on a series S str...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein [139-379,H232R](Homo sapiens (Human))
Janssen Biotech

US Patent
LigandPNGBDBM501364(US11021511, Compound 6c)
Affinity DataEC50:  60nMAssay Description:Agonism of the human STING pathway is assessed in THP1-ISG cells (Invivogen, cat #thp-isg) derived from human THP1 monocyte cell line by stable integ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein [139-379,H232R](Homo sapiens (Human))
Janssen Biotech

US Patent
LigandPNGBDBM501363(US11021511, Compound 6b)
Affinity DataKd:  1.70nMAssay Description:Compounds were analyzed on an S200 biacore SPR instrument (GE Healthcare). E. coli produced truncated STING protein was immobilized on a series S str...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein [139-379,H232R](Homo sapiens (Human))
Janssen Biotech

US Patent
LigandPNGBDBM501363(US11021511, Compound 6b)
Affinity DataEC50:  107nMAssay Description:Agonism of the human STING pathway is assessed in THP1-ISG cells (Invivogen, cat #thp-isg) derived from human THP1 monocyte cell line by stable integ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein [139-379,H232R](Homo sapiens (Human))
Janssen Biotech

US Patent
LigandPNGBDBM501362(US11021511, Compound 6a)
Affinity DataKd:  6nMAssay Description:Compounds were analyzed on an S200 biacore SPR instrument (GE Healthcare). E. coli produced truncated STING protein was immobilized on a series S str...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein [139-379,H232R](Homo sapiens (Human))
Janssen Biotech

US Patent
LigandPNGBDBM501362(US11021511, Compound 6a)
Affinity DataEC50:  53nMAssay Description:Agonism of the human STING pathway is assessed in THP1-ISG cells (Invivogen, cat #thp-isg) derived from human THP1 monocyte cell line by stable integ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein [139-379,H232R](Homo sapiens (Human))
Janssen Biotech

US Patent
LigandPNGBDBM501361(US11021511, Compound 5)
Affinity DataKd: <10nMAssay Description:Compounds were analyzed on an S200 biacore SPR instrument (GE Healthcare). E. coli produced truncated STING protein was immobilized on a series S str...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein [139-379,H232R](Homo sapiens (Human))
Janssen Biotech

US Patent
LigandPNGBDBM501361(US11021511, Compound 5)
Affinity DataEC50:  210nMAssay Description:Agonism of the human STING pathway is assessed in THP1-ISG cells (Invivogen, cat #thp-isg) derived from human THP1 monocyte cell line by stable integ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein [139-379,H232R](Homo sapiens (Human))
Janssen Biotech

US Patent
LigandPNGBDBM501204(US11021511, Compound 4)
Affinity DataEC50:  19nMAssay Description:Agonism of the human STING pathway is assessed in THP1-ISG cells (Invivogen, cat #thp-isg) derived from human THP1 monocyte cell line by stable integ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetStimulator of interferon genes protein [139-379,H232R](Homo sapiens (Human))
Janssen Biotech

US Patent
LigandPNGBDBM501193(US11021511, Compound 1)
Affinity DataEC50:  1.81E+3nMAssay Description:Agonism of the human STING pathway is assessed in THP1-ISG cells (Invivogen, cat #thp-isg) derived from human THP1 monocyte cell line by stable integ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent