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Patent code US11028064

Compile Data Set for Download or QSAR
Found 146 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501688
PNG
(3-({5-[2-(Dimethylamino)ethoxy]-9-oxo-9H-xanthen-3...)
Show SMILES CN(C)CCOc1cccc2c1oc1cc(Oc3cccc(c3)C(=O)Nc3ccccc3)ccc1c2=O
Show InChI InChI=1S/C30H26N2O5/c1-32(2)16-17-35-26-13-7-12-25-28(33)24-15-14-23(19-27(24)37-29(25)26)36-22-11-6-8-20(18-22)30(34)31-21-9-4-3-5-10-21/h3-15,18-19H,16-17H2,1-2H3,(H,31,34)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501699
PNG
(4-(2-(Dimethylamino)ethoxy)-2-methyl-6-((6-((6-(tr...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(OCc4ccc(nc4)C(F)(F)F)nc3)ccc1c2=O
Show InChI InChI=1S/C30H26F3N3O5/c1-18-12-23-28(37)22-7-5-20(14-24(22)41-29(23)25(13-18)38-11-10-36(2)3)40-21-6-9-27(35-16-21)39-17-19-4-8-26(34-15-19)30(31,32)33/h4-9,12-16H,10-11,17H2,1-3H3
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501702
PNG
(4-(2-(Dimethylamino)ethoxy)-6-((6-(((6-methoxypyri...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(NCc4ccc(CO)nc4)nc3)ccc1c2=O
Show InChI InChI=1S/C30H30N4O5/c1-19-12-25-29(36)24-8-6-22(14-26(24)39-30(25)27(13-19)37-11-10-34(2)3)38-23-7-9-28(33-17-23)32-16-20-4-5-21(18-35)31-15-20/h4-9,12-15,17,35H,10-11,16,18H2,1-3H3,(H,32,33)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501713
PNG
(N-(2-(5-((5-(2-(Dimethylamino)ethoxy)-7-methyl-9-o...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(CCNC(=O)N4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C30H34N4O5/c1-20-16-25-28(35)24-9-8-22(18-26(24)39-29(25)27(17-20)37-15-14-33(2)3)38-23-7-6-21(32-19-23)10-11-31-30(36)34-12-4-5-13-34/h6-9,16-19H,4-5,10-15H2,1-3H3,(H,31,36)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501731
PNG
(N-Cyclopentyl-3-(5-((7-(2-(dimethylamino)ethoxy)-5...)
Show SMILES CN(C)CCOc1cc(C)c2oc3cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc3c(=O)c2c1
Show InChI InChI=1S/C31H35N3O5/c1-20-16-25(37-15-14-34(2)3)17-27-30(36)26-12-11-23(18-28(26)39-31(20)27)38-24-10-8-21(32-19-24)9-13-29(35)33-22-6-4-5-7-22/h8,10-12,16-19,22H,4-7,9,13-15H2,1-3H3,(H,33,35)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501732
PNG
(N-Cyclopentyl-3-(5-((7-(2-(dimethylamino)ethoxy)-5...)
Show SMILES COc1cc(OCCN(C)C)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C31H35N3O6/c1-34(2)14-15-38-24-16-26-30(36)25-12-11-22(17-27(25)40-31(26)28(18-24)37-3)39-23-10-8-20(32-19-23)9-13-29(35)33-21-6-4-5-7-21/h8,10-12,16-19,21H,4-7,9,13-15H2,1-3H3,(H,33,35)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501740
PNG
(4-(2-(Dimethylamino)ethoxy)-2-methyl-6-((6-(3-(4-m...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)N4CCC(N)CC4)nc3)ccc1c2=O
Show InChI InChI=1S/C31H36N4O5/c1-20-16-26-30(37)25-8-7-23(18-27(25)40-31(26)28(17-20)38-15-14-34(2)3)39-24-6-4-22(33-19-24)5-9-29(36)35-12-10-21(32)11-13-35/h4,6-8,16-19,21H,5,9-15,32H2,1-3H3
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501741
PNG
(N-Cyclopentyl-3-(5-((5-(2-(diethylamino)ethoxy)-7-...)
Show SMILES CCN(CC)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C33H39N3O5/c1-4-36(5-2)16-17-39-30-19-22(3)18-28-32(38)27-14-13-25(20-29(27)41-33(28)30)40-26-12-10-23(34-21-26)11-15-31(37)35-24-8-6-7-9-24/h10,12-14,18-21,24H,4-9,11,15-17H2,1-3H3,(H,35,37)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501753
PNG
(N-Cyclopentyl-3-(5-((5-(3-((3S,5R)-3,5-dimethylpip...)
Show SMILES C[C@H]1CN(CCCOc2cc(C)cc3c2oc2cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc2c3=O)C[C@@H](C)N1
Show InChI InChI=1S/C36H44N4O5/c1-23-17-31-35(42)30-13-12-28(44-29-11-9-26(37-20-29)10-14-34(41)39-27-7-4-5-8-27)19-32(30)45-36(31)33(18-23)43-16-6-15-40-21-24(2)38-25(3)22-40/h9,11-13,17-20,24-25,27,38H,4-8,10,14-16,21-22H2,1-3H3,(H,39,41)/t24-,25+
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501760
PNG
(N-Cyclopentyl-3-(5-((7-methyl-5-((1-methylpiperidi...)
Show SMILES CN1CCCCC1COc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C34H39N3O5/c1-22-17-29-33(39)28-14-13-26(19-30(28)42-34(29)31(18-22)40-21-25-9-5-6-16-37(25)2)41-27-12-10-23(35-20-27)11-15-32(38)36-24-7-3-4-8-24/h10,12-14,17-20,24-25H,3-9,11,15-16,21H2,1-2H3,(H,36,38)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501761
PNG
(N-Cyclopentyl-3-(5-((7-methyl-5-(2-(1-methylpyrrol...)
Show SMILES CN1CCCC1CCOc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C34H39N3O5/c1-22-18-29-33(39)28-13-12-26(20-30(28)42-34(29)31(19-22)40-17-15-25-8-5-16-37(25)2)41-27-11-9-23(35-21-27)10-14-32(38)36-24-6-3-4-7-24/h9,11-13,18-21,24-25H,3-8,10,14-17H2,1-2H3,(H,36,38)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501691
PNG
(3-((5-(2-(Dimethylamino)ethoxy)-7-methyl-9-oxo-9H-...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3cccc(c3)C(=O)Nc3ccccc3)ccc1c2=O
Show InChI InChI=1S/C31H28N2O5/c1-20-16-26-29(34)25-13-12-24(19-27(25)38-30(26)28(17-20)36-15-14-33(2)3)37-23-11-7-8-21(18-23)31(35)32-22-9-5-4-6-10-22/h4-13,16-19H,14-15H2,1-3H3,(H,32,35)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501696
PNG
(4-(2-(Dimethylamino)ethoxy)-6-((6-((4-methoxybenzy...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(OCc4ccc(CO)cc4)nc3)ccc1c2=O
Show InChI InChI=1S/C31H30N2O6/c1-20-14-26-30(35)25-10-8-23(16-27(25)39-31(26)28(15-20)36-13-12-33(2)3)38-24-9-11-29(32-17-24)37-19-22-6-4-21(18-34)5-7-22/h4-11,14-17,34H,12-13,18-19H2,1-3H3
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501698
PNG
(4-(2-(Dimethylamino)ethoxy)-6-((5-methoxy-6-((4-me...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3cnc(OCc4ccc(CO)cc4)c(CO)c3)ccc1c2=O
Show InChI InChI=1S/C32H32N2O7/c1-20-12-27-30(37)26-9-8-24(15-28(26)41-31(27)29(13-20)38-11-10-34(2)3)40-25-14-23(18-36)32(33-16-25)39-19-22-6-4-21(17-35)5-7-22/h4-9,12-16,35-36H,10-11,17-19H2,1-3H3
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501709
PNG
(4-(2-(Dimethylamino)ethoxy)-2-methyl-6-((6-(3-oxo-...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)N4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C30H33N3O5/c1-20-16-25-29(35)24-10-9-22(18-26(24)38-30(25)27(17-20)36-15-14-32(2)3)37-23-8-6-21(31-19-23)7-11-28(34)33-12-4-5-13-33/h6,8-10,16-19H,4-5,7,11-15H2,1-3H3
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501718
PNG
(1-(3-((5-(3-(Dimethylamino)propoxy)-7-methyl-9-oxo...)
Show SMILES CN(C)CCCOc1cc(C)cc2c1oc1cc(Oc3cccc(NC(=O)Nc4ccccc4)c3)ccc1c2=O
Show InChI InChI=1S/C32H31N3O5/c1-21-17-27-30(36)26-14-13-25(20-28(26)40-31(27)29(18-21)38-16-8-15-35(2)3)39-24-12-7-11-23(19-24)34-32(37)33-22-9-5-4-6-10-22/h4-7,9-14,17-20H,8,15-16H2,1-3H3,(H2,33,34,37)
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Reactome pathway
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501723
PNG
(N-Cyclopentyl-3-(5-((7-methyl-9-oxo-5-(2-(pyrrolid...)
Show SMILES Cc1cc(OCCN2CCCC2)c2oc3cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc3c(=O)c2c1
Show InChI InChI=1S/C33H37N3O5/c1-22-18-28-32(38)27-12-11-25(20-29(27)41-33(28)30(19-22)39-17-16-36-14-4-5-15-36)40-26-10-8-23(34-21-26)9-13-31(37)35-24-6-2-3-7-24/h8,10-12,18-21,24H,2-7,9,13-17H2,1H3,(H,35,37)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501737
PNG
(N-Cyclopentyl-3-(5-((5-(2-(dimethylamino)ethoxy)-7...)
Show SMILES CN(C)CCOc1cc(C)cc2c1sc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C31H35N3O4S/c1-20-16-26-30(36)25-12-11-23(18-28(25)39-31(26)27(17-20)37-15-14-34(2)3)38-24-10-8-21(32-19-24)9-13-29(35)33-22-6-4-5-7-22/h8,10-12,16-19,22H,4-7,9,13-15H2,1-3H3,(H,33,35)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501749
PNG
(N-Cyclopentyl-3-(5-((5-(3-(dimethylamino)propoxy)-...)
Show SMILES CN(C)CCCOc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C32H37N3O5/c1-21-17-27-31(37)26-13-12-24(19-28(26)40-32(27)29(18-21)38-16-6-15-35(2)3)39-25-11-9-22(33-20-25)10-14-30(36)34-23-7-4-5-8-23/h9,11-13,17-20,23H,4-8,10,14-16H2,1-3H3,(H,34,36)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501697
PNG
(4-(2-(Dimethylamino)ethoxy)-6-((6-((6-methoxypyrid...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(OCc4ccc(CO)nc4)nc3)ccc1c2=O
Show InChI InChI=1S/C30H29N3O6/c1-19-12-25-29(35)24-8-6-22(14-26(24)39-30(25)27(13-19)36-11-10-33(2)3)38-23-7-9-28(32-16-23)37-18-20-4-5-21(17-34)31-15-20/h4-9,12-16,34H,10-11,17-18H2,1-3H3
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501715
PNG
(N-Cyclopentyl-3-(5-((7-methyl-5-(2-(methylamino)et...)
Show SMILES CN(CCOc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O)C(=O)OC(C)(C)C
Show InChI InChI=1S/C35H41N3O7/c1-22-18-28-32(40)27-14-13-25(43-26-12-10-23(36-21-26)11-15-31(39)37-24-8-6-7-9-24)20-29(27)44-33(28)30(19-22)42-17-16-38(5)34(41)45-35(2,3)4/h10,12-14,18-21,24H,6-9,11,15-17H2,1-5H3,(H,37,39)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501750
PNG
(N-Cyclopentyl-3-(5-((5-(3-((2R,6S)-2,6-dimethylpip...)
Show SMILES C[C@H]1CCC[C@@H](C)N1CCCOc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C37H45N3O5/c1-24-20-32-36(42)31-16-15-29(44-30-14-12-27(38-23-30)13-17-35(41)39-28-10-4-5-11-28)22-33(31)45-37(32)34(21-24)43-19-7-18-40-25(2)8-6-9-26(40)3/h12,14-16,20-23,25-26,28H,4-11,13,17-19H2,1-3H3,(H,39,41)/t25-,26+
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501754
PNG
(N-Cyclopentyl-3-(5-((7-methyl-9-oxo-5-(3-((3S,5R)-...)
Show SMILES C[C@H]1CN(CCCOc2cc(C)cc3c2oc2cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc2c3=O)C[C@@H](C)N1C
Show InChI InChI=1S/C37H46N4O5/c1-24-18-32-36(43)31-14-13-29(45-30-12-10-27(38-21-30)11-15-35(42)39-28-8-5-6-9-28)20-33(31)46-37(32)34(19-24)44-17-7-16-41-22-25(2)40(4)26(3)23-41/h10,12-14,18-21,25-26,28H,5-9,11,15-17,22-23H2,1-4H3,(H,39,42)/t25-,26+
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501758
PNG
((R)—N-Cyclopentyl-3-(5-((7-methyl-5-((1-methylpyrr...)
Show SMILES CN1CCC[C@@H]1COc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C33H37N3O5/c1-21-16-28-32(38)27-13-12-25(18-29(27)41-33(28)30(17-21)39-20-24-8-5-15-36(24)2)40-26-11-9-22(34-19-26)10-14-31(37)35-23-6-3-4-7-23/h9,11-13,16-19,23-24H,3-8,10,14-15,20H2,1-2H3,(H,35,37)/t24-/m1/s1
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501692
PNG
(1-(3-((5-(2-(Dimethylamino)ethoxy)-7-methyl-9-oxo-...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3cccc(NC(=O)Nc4ccccc4)c3)ccc1c2=O
Show InChI InChI=1S/C31H29N3O5/c1-20-16-26-29(35)25-13-12-24(19-27(25)39-30(26)28(17-20)37-15-14-34(2)3)38-23-11-7-10-22(18-23)33-31(36)32-21-8-5-4-6-9-21/h4-13,16-19H,14-15H2,1-3H3,(H2,32,33,36)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501695
PNG
(6-((5,6-Dimethoxypyridin-3-yl)oxy)-4-(2-(dimethyla...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3cnc(CO)c(CO)c3)ccc1c2=O
Show InChI InChI=1S/C25H26N2O6/c1-15-8-20-24(30)19-5-4-17(32-18-10-16(13-28)21(14-29)26-12-18)11-22(19)33-25(20)23(9-15)31-7-6-27(2)3/h4-5,8-12,28-29H,6-7,13-14H2,1-3H3
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501700
PNG
(4-(2-(Dimethylamino)ethoxy)-6-((6-((4-methoxybenzy...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(NCc4ccc(CO)cc4)nc3)ccc1c2=O
Show InChI InChI=1S/C31H31N3O5/c1-20-14-26-30(36)25-10-8-23(16-27(25)39-31(26)28(15-20)37-13-12-34(2)3)38-24-9-11-29(33-18-24)32-17-21-4-6-22(19-35)7-5-21/h4-11,14-16,18,35H,12-13,17,19H2,1-3H3,(H,32,33)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501707
PNG
(3-(5-((5-(2-(Dimethylamino)ethoxy)-7-methyl-9-oxo-...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(ccc1c2=O)C(=O)c1ccc(CCC(=O)Nc2cccnc2)nc1
Show InChI InChI=1S/C32H30N4O5/c1-20-15-26-31(39)25-10-7-21(17-27(25)41-32(26)28(16-20)40-14-13-36(2)3)30(38)22-6-8-23(34-18-22)9-11-29(37)35-24-5-4-12-33-19-24/h4-8,10,12,15-19H,9,11,13-14H2,1-3H3,(H,35,37)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501745
PNG
(N-Cyclopentyl-3-(5-((7-methyl-9-oxo-5-(2-(4-(2,2,2...)
Show SMILES Cc1cc(OCCN2CCN(CC(F)(F)F)CC2)c2oc3cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc3c(=O)c2c1
Show InChI InChI=1S/C35H39F3N4O5/c1-23-18-29-33(44)28-10-9-26(46-27-8-6-24(39-21-27)7-11-32(43)40-25-4-2-3-5-25)20-30(28)47-34(29)31(19-23)45-17-16-41-12-14-42(15-13-41)22-35(36,37)38/h6,8-10,18-21,25H,2-5,7,11-17,22H2,1H3,(H,40,43)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501746
PNG
(N-Cyclopentyl-3-(5-((7-methyl-5-((1-methylpiperidi...)
Show SMILES CN1CCCC(C1)Oc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C33H37N3O5/c1-21-16-28-32(38)27-13-12-24(18-29(27)41-33(28)30(17-21)40-26-8-5-15-36(2)20-26)39-25-11-9-22(34-19-25)10-14-31(37)35-23-6-3-4-7-23/h9,11-13,16-19,23,26H,3-8,10,14-15,20H2,1-2H3,(H,35,37)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501751
PNG
(N-Cyclopentyl-3-(5-((5-(3-(4-ethylpiperazin-1-yl)p...)
Show SMILES CCN1CCN(CCCOc2cc(C)cc3c2oc2cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc2c3=O)CC1
Show InChI InChI=1S/C36H44N4O5/c1-3-39-16-18-40(19-17-39)15-6-20-43-33-22-25(2)21-31-35(42)30-13-12-28(23-32(30)45-36(31)33)44-29-11-9-26(37-24-29)10-14-34(41)38-27-7-4-5-8-27/h9,11-13,21-24,27H,3-8,10,14-20H2,1-2H3,(H,38,41)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501752
PNG
(N-Cyclopentyl-3-(5-((5-(3-(4-isopropylpiperazin-1-...)
Show SMILES CC(C)N1CCN(CCCOc2cc(C)cc3c2oc2cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc2c3=O)CC1
Show InChI InChI=1S/C37H46N4O5/c1-25(2)41-18-16-40(17-19-41)15-6-20-44-34-22-26(3)21-32-36(43)31-13-12-29(23-33(31)46-37(32)34)45-30-11-9-27(38-24-30)10-14-35(42)39-28-7-4-5-8-28/h9,11-13,21-25,28H,4-8,10,14-20H2,1-3H3,(H,39,42)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501756
PNG
(N-Cyclopentyl-3-(5-((7-methyl-5-((1-methylpyrrolid...)
Show SMILES CN1CCC(C1)Oc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C32H35N3O5/c1-20-15-27-31(37)26-11-10-23(17-28(26)40-32(27)29(16-20)39-25-13-14-35(2)19-25)38-24-9-7-21(33-18-24)8-12-30(36)34-22-5-3-4-6-22/h7,9-11,15-18,22,25H,3-6,8,12-14,19H2,1-2H3,(H,34,36)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501759
PNG
((S)—N-Cyclopentyl-3-(5-((7-methyl-5-((1-methylpyrr...)
Show SMILES CN1CCC[C@H]1COc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C33H37N3O5/c1-21-16-28-32(38)27-13-12-25(18-29(27)41-33(28)30(17-21)39-20-24-8-5-15-36(24)2)40-26-11-9-22(34-19-26)10-14-31(37)35-23-6-3-4-7-23/h9,11-13,16-19,23-24H,3-8,10,14-15,20H2,1-2H3,(H,35,37)/t24-/m0/s1
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501710
PNG
(4-(2-(Dimethylamino)ethoxy)-2-methyl-6-((6-(3-morp...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)N4CCOCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C30H33N3O6/c1-20-16-25-29(35)24-8-7-22(18-26(24)39-30(25)27(17-20)37-15-10-32(2)3)38-23-6-4-21(31-19-23)5-9-28(34)33-11-13-36-14-12-33/h4,6-8,16-19H,5,9-15H2,1-3H3
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501712
PNG
(N-(2-(5-((5-(2-(Dimethylamino)ethoxy)-7-methyl-9-o...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(CCNC(=O)C4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C31H35N3O5/c1-20-16-26-29(35)25-11-10-23(18-27(25)39-30(26)28(17-20)37-15-14-34(2)3)38-24-9-8-22(33-19-24)12-13-32-31(36)21-6-4-5-7-21/h8-11,16-19,21H,4-7,12-15H2,1-3H3,(H,32,36)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501714
PNG
(3-(5-((5-(2-Aminoethoxy)-7-methyl-9-oxo-9H-xanthen...)
Show SMILES Cc1cc(OCCNC(=O)OC(C)(C)C)c2oc3cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc3c(=O)c2c1
Show InChI InChI=1S/C34H39N3O7/c1-21-17-27-31(39)26-13-12-24(42-25-11-9-22(36-20-25)10-14-30(38)37-23-7-5-6-8-23)19-28(26)43-32(27)29(18-21)41-16-15-35-33(40)44-34(2,3)4/h9,11-13,17-20,23H,5-8,10,14-16H2,1-4H3,(H,35,40)(H,37,38)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501718
PNG
(1-(3-((5-(3-(Dimethylamino)propoxy)-7-methyl-9-oxo...)
Show SMILES CN(C)CCCOc1cc(C)cc2c1oc1cc(Oc3cccc(NC(=O)Nc4ccccc4)c3)ccc1c2=O
Show InChI InChI=1S/C32H31N3O5/c1-21-17-27-30(36)26-14-13-25(20-28(26)40-31(27)29(18-21)38-16-8-15-35(2)3)39-24-12-7-11-23(19-24)34-32(37)33-22-9-5-4-6-10-22/h4-7,9-14,17-20H,8,15-16H2,1-3H3,(H2,33,34,37)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501736
PNG
(4-(2-(Dimethylamino)ethoxy)-6-((6-(4-methoxyphenet...)
Show SMILES CN(C)CCOc1cc(C)cc2c1sc1cc(Oc3ccc(CCc4ccc(CO)cc4)nc3)ccc1c2=O
Show InChI InChI=1S/C32H32N2O4S/c1-21-16-28-31(36)27-13-12-25(18-30(27)39-32(28)29(17-21)37-15-14-34(2)3)38-26-11-10-24(33-19-26)9-8-22-4-6-23(20-35)7-5-22/h4-7,10-13,16-19,35H,8-9,14-15,20H2,1-3H3
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501755
PNG
(N-Cyclopentyl-3-[5-({7-methyl-5-[3-(4-morpholinyl)...)
Show SMILES Cc1cc(OCCCN2CCOCC2)c2oc3cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc3c(=O)c2c1
Show InChI InChI=1S/C34H39N3O6/c1-23-19-29-33(39)28-11-10-26(42-27-9-7-24(35-22-27)8-12-32(38)36-25-5-2-3-6-25)21-30(28)43-34(29)31(20-23)41-16-4-13-37-14-17-40-18-15-37/h7,9-11,19-22,25H,2-6,8,12-18H2,1H3,(H,36,38)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501693
PNG
(4-(2-(Dimethylamino)ethoxy)-6-(3-methoxy-4-((4-met...)
Show SMILES COc1cc(Oc2ccc3c(c2)oc2c(OCCN(C)C)cc(C)cc2c3=O)ccc1OCc1ccc(CO)cc1
Show InChI InChI=1S/C33H33NO7/c1-21-15-27-32(36)26-11-9-24(17-29(26)41-33(27)31(16-21)38-14-13-34(2)3)40-25-10-12-28(30(18-25)37-4)39-20-23-7-5-22(19-35)6-8-23/h5-12,15-18,35H,13-14,19-20H2,1-4H3
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501701
PNG
(4-(2-(Dimethylamino)ethoxy)-2-methyl-6-((6-((4-(tr...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(NCc4ccc(cc4)C#[F][O](F)F)nc3)ccc1c2=O
Show InChI InChI=1S/C31H28F3N3O5/c1-20-14-26-30(38)25-10-8-23(16-27(25)41-31(26)28(15-20)39-13-12-37(2)3)40-24-9-11-29(36-19-24)35-18-22-6-4-21(5-7-22)17-34-42(32)33/h4-11,14-16,19H,12-13,18H2,1-3H3,(H,35,36)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501704
PNG
(4-(2-(Dimethylamino)ethoxy)-6-((6-(4-methoxyphenet...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(CCc4ccc(CO)cc4)nc3)ccc1c2=O
Show InChI InChI=1S/C32H32N2O5/c1-21-16-28-31(36)27-13-12-25(18-29(27)39-32(28)30(17-21)37-15-14-34(2)3)38-26-11-10-24(33-19-26)9-8-22-4-6-23(20-35)7-5-22/h4-7,10-13,16-19,35H,8-9,14-15,20H2,1-3H3
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501711
PNG
(N-Cyclopentyl-2-((5-((5-(2-(dimethylamino)ethoxy)-...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(nc3)N(CC(=O)NC3CCCC3)C(=O)OC(C)(C)C)ccc1c2=O
Show InChI InChI=1S/C35H42N4O7/c1-22-17-27-32(41)26-13-11-24(19-28(26)45-33(27)29(18-22)43-16-15-38(5)6)44-25-12-14-30(36-20-25)39(34(42)46-35(2,3)4)21-31(40)37-23-9-7-8-10-23/h11-14,17-20,23H,7-10,15-16,21H2,1-6H3,(H,37,40)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501717
PNG
(3-((5-(3-(Dimethylamino)propoxy)-7-methyl-9-oxo-9H...)
Show SMILES CN(C)CCCOc1cc(C)cc2c1oc1cc(Oc3cccc(c3)C(=O)Nc3ccccc3)ccc1c2=O
Show InChI InChI=1S/C32H30N2O5/c1-21-17-27-30(35)26-14-13-25(20-28(26)39-31(27)29(18-21)37-16-8-15-34(2)3)38-24-12-7-9-22(19-24)32(36)33-23-10-5-4-6-11-23/h4-7,9-14,17-20H,8,15-16H2,1-3H3,(H,33,36)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501726
PNG
(3-({7-Chloro-5-[2-(dimethylamino)ethoxy]-9-oxo-9H-...)
Show SMILES CN(C)CCOc1cc(Cl)cc2c1oc1cc(Oc3cccc(c3)C(=O)Nc3ccccc3)ccc1c2=O
Show InChI InChI=1S/C30H25ClN2O5/c1-33(2)13-14-36-27-17-20(31)16-25-28(34)24-12-11-23(18-26(24)38-29(25)27)37-22-10-6-7-19(15-22)30(35)32-21-8-4-3-5-9-21/h3-12,15-18H,13-14H2,1-2H3,(H,32,35)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501728
PNG
(3-(5-((7-Bromo-5-(2-(dimethylamino)ethoxy)-9-oxo-9...)
Show SMILES CN(C)CCOc1cc(Br)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C30H32BrN3O5/c1-34(2)13-14-37-27-16-19(31)15-25-29(36)24-11-10-22(17-26(24)39-30(25)27)38-23-9-7-20(32-18-23)8-12-28(35)33-21-5-3-4-6-21/h7,9-11,15-18,21H,3-6,8,12-14H2,1-2H3,(H,33,35)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501735
PNG
(3-((5-(2-(Dimethylamino)ethoxy)-7-methyl-9-oxo-9H-...)
Show SMILES CN(C)CCOc1cc(C)cc2c1sc1cc(Oc3cccc(c3)C(=O)Nc3ccccc3)ccc1c2=O
Show InChI InChI=1S/C31H28N2O4S/c1-20-16-26-29(34)25-13-12-24(19-28(25)38-30(26)27(17-20)36-15-14-33(2)3)37-23-11-7-8-21(18-23)31(35)32-22-9-5-4-6-10-22/h4-13,16-19H,14-15H2,1-3H3,(H,32,35)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501692
PNG
(1-(3-((5-(2-(Dimethylamino)ethoxy)-7-methyl-9-oxo-...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3cccc(NC(=O)Nc4ccccc4)c3)ccc1c2=O
Show InChI InChI=1S/C31H29N3O5/c1-20-16-26-29(35)25-13-12-24(19-27(25)39-30(26)28(17-20)37-15-14-34(2)3)38-23-11-7-10-22(18-23)33-31(36)32-21-8-5-4-6-9-21/h4-13,16-19H,14-15H2,1-3H3,(H2,32,33,36)
PDB
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KEGG

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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501706
PNG
((2-(Dimethylamino)ethoxy)-6-(6-((4-methoxybenzyl)o...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(ccc1c2=O)C(=O)c1ccc(CCc2ccc(CO)cc2)nc1
Show InChI InChI=1S/C33H32N2O5/c1-21-16-28-32(38)27-13-10-24(18-29(27)40-33(28)30(17-21)39-15-14-35(2)3)31(37)25-9-12-26(34-19-25)11-8-22-4-6-23(20-36)7-5-22/h4-7,9-10,12-13,16-19,36H,8,11,14-15,20H2,1-3H3
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501708
PNG
(N-Cyclopentyl-3-(5-((5-(2-(dimethylamino)ethoxy)-7...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C31H35N3O5/c1-20-16-26-30(36)25-12-11-23(18-27(25)39-31(26)28(17-20)37-15-14-34(2)3)38-24-10-8-21(32-19-24)9-13-29(35)33-22-6-4-5-7-22/h8,10-12,16-19,22H,4-7,9,13-15H2,1-3H3,(H,33,35)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501730
PNG
(N-Cyclopentyl-3-(5-((7-(2-(dimethylamino)ethoxy)-9...)
Show SMILES CN(C)CCOc1ccc2oc3cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc3c(=O)c2c1
Show InChI InChI=1S/C30H33N3O5/c1-33(2)15-16-36-22-11-13-27-26(17-22)30(35)25-12-10-23(18-28(25)38-27)37-24-9-7-20(31-19-24)8-14-29(34)32-21-5-3-4-6-21/h7,9-13,17-19,21H,3-6,8,14-16H2,1-2H3,(H,32,34)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501733
PNG
(N-Cyclopentyl-3-(5-((6-(2-(dimethylamino)ethoxy)-9...)
Show SMILES CN(C)CCOc1ccc2c(c1)oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C30H33N3O5/c1-33(2)15-16-36-22-10-12-25-27(17-22)38-28-18-23(11-13-26(28)30(25)35)37-24-9-7-20(31-19-24)8-14-29(34)32-21-5-3-4-6-21/h7,9-13,17-19,21H,3-6,8,14-16H2,1-2H3,(H,32,34)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501743
PNG
(N-Cyclopentyl-3-[5-({5-[2-(diisopropylamino)ethoxy...)
Show SMILES CC(C)N(CCOc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O)C(C)C
Show InChI InChI=1S/C35H43N3O5/c1-22(2)38(23(3)4)16-17-41-32-19-24(5)18-30-34(40)29-14-13-27(20-31(29)43-35(30)32)42-28-12-10-25(36-21-28)11-15-33(39)37-26-8-6-7-9-26/h10,12-14,18-23,26H,6-9,11,15-17H2,1-5H3,(H,37,39)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501747
PNG
(N-Cyclopentyl-3-(5-((5-(2-((3S,5R)-3,5-dimethylpip...)
Show SMILES C[C@H]1CN(CCOc2cc(C)cc3c2oc2cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc2c3=O)C[C@@H](C)N1
Show InChI InChI=1S/C35H42N4O5/c1-22-16-30-34(41)29-12-11-27(43-28-10-8-25(36-19-28)9-13-33(40)38-26-6-4-5-7-26)18-31(29)44-35(30)32(17-22)42-15-14-39-20-23(2)37-24(3)21-39/h8,10-12,16-19,23-24,26,37H,4-7,9,13-15,20-21H2,1-3H3,(H,38,40)/t23-,24+
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501748
PNG
(N-Cyclopentyl-3-(5-((7-methyl-9-oxo-5-(2-((3S,5R)-...)
Show SMILES C[C@H]1CN(CCOc2cc(C)cc3c2oc2cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc2c3=O)C[C@@H](C)N1C
Show InChI InChI=1S/C36H44N4O5/c1-23-17-31-35(42)30-13-12-28(44-29-11-9-26(37-20-29)10-14-34(41)38-27-7-5-6-8-27)19-32(30)45-36(31)33(18-23)43-16-15-40-21-24(2)39(4)25(3)22-40/h9,11-13,17-20,24-25,27H,5-8,10,14-16,21-22H2,1-4H3,(H,38,41)/t24-,25+
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501724
PNG
(N-Cyclopentyl-3-(5-((7-methyl-9-oxo-5-(2-(piperidi...)
Show SMILES Cc1cc(OCCN2CCCCC2)c2oc3cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc3c(=O)c2c1
Show InChI InChI=1S/C34H39N3O5/c1-23-19-29-33(39)28-13-12-26(21-30(28)42-34(29)31(20-23)40-18-17-37-15-5-2-6-16-37)41-27-11-9-24(35-22-27)10-14-32(38)36-25-7-3-4-8-25/h9,11-13,19-22,25H,2-8,10,14-18H2,1H3,(H,36,38)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501729
PNG
(N-Cyclopentyl-3-(5-((5-(2-(dimethylamino)ethoxy)-7...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Sc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C31H35N3O4S/c1-20-16-26-30(36)25-12-11-23(18-27(25)38-31(26)28(17-20)37-15-14-34(2)3)39-24-10-8-21(32-19-24)9-13-29(35)33-22-6-4-5-7-22/h8,10-12,16-19,22H,4-7,9,13-15H2,1-3H3,(H,33,35)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501742
PNG
(N-Cyclopentyl-3-[5-({7-methyl-5-[2-(4-morpholinyl)...)
Show SMILES Cc1cc(OCCN2CCOCC2)c2oc3cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc3c(=O)c2c1
Show InChI InChI=1S/C33H37N3O6/c1-22-18-28-32(38)27-10-9-25(20-29(27)42-33(28)30(19-22)40-17-14-36-12-15-39-16-13-36)41-26-8-6-23(34-21-26)7-11-31(37)35-24-4-2-3-5-24/h6,8-10,18-21,24H,2-5,7,11-17H2,1H3,(H,35,37)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501744
PNG
(N-Cyclopentyl-3-(5-((7-methyl-5-(2-(4-methylpipera...)
Show SMILES CN1CCN(CCOc2cc(C)cc3c2oc2cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc2c3=O)CC1
Show InChI InChI=1S/C34H40N4O5/c1-23-19-29-33(40)28-11-10-26(42-27-9-7-24(35-22-27)8-12-32(39)36-25-5-3-4-6-25)21-30(28)43-34(29)31(20-23)41-18-17-38-15-13-37(2)14-16-38/h7,9-11,19-22,25H,3-6,8,12-18H2,1-2H3,(H,36,39)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501757
PNG
(N-Cyclopentyl-3-[5-({7-methyl-5-[(1-methyl-4-piper...)
Show SMILES CN1CCC(CC1)Oc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C33H37N3O5/c1-21-17-28-32(38)27-11-10-25(19-29(27)41-33(28)30(18-21)40-24-13-15-36(2)16-14-24)39-26-9-7-22(34-20-26)8-12-31(37)35-23-5-3-4-6-23/h7,9-11,17-20,23-24H,3-6,8,12-16H2,1-2H3,(H,35,37)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501762
PNG
(N-Cyclopentyl-3-(5-((7-methyl-5-((1-methylpiperidi...)
Show SMILES CN1CCCC(COc2cc(C)cc3c2oc2cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc2c3=O)C1
Show InChI InChI=1S/C34H39N3O5/c1-22-16-29-33(39)28-13-12-26(18-30(28)42-34(29)31(17-22)40-21-23-6-5-15-37(2)20-23)41-27-11-9-24(35-19-27)10-14-32(38)36-25-7-3-4-8-25/h9,11-13,16-19,23,25H,3-8,10,14-15,20-21H2,1-2H3,(H,36,38)
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n/an/a<100n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501705
PNG
(4-(2-(Dimethylamino)ethoxy)-6-((6-methoxypyridin-3...)
Show SMILES COc1cc(C)cc2c1oc1cc(ccc1c2=O)B1OC(C)(C)C(C)(C)O1
Show InChI InChI=1S/C21H23BO5/c1-12-9-15-18(23)14-8-7-13(22-26-20(2,3)21(4,5)27-22)11-16(14)25-19(15)17(10-12)24-6/h7-11H,1-6H3
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n/an/a 550n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501734
PNG
(4-(2-(Dimethylamino)ethoxy)-2-methyl-6-phenoxy-9H-...)
Show SMILES CN(C)CCOc1cc(C)cc2c1sc1cc(Oc3ccccc3)ccc1c2=O
Show InChI InChI=1S/C24H23NO3S/c1-16-13-20-23(26)19-10-9-18(28-17-7-5-4-6-8-17)15-22(19)29-24(20)21(14-16)27-12-11-25(2)3/h4-10,13-15H,11-12H2,1-3H3
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n/an/a 550n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501689
PNG
(5-[2-(Dimethylamino)ethoxy]-3-({6-[2-(4-methoxyphe...)
Show SMILES CN(C)CCOc1cccc2c1oc1cc(Oc3ccc(CCc4ccc(CO)cc4)nc3)ccc1c2=O
Show InChI InChI=1S/C31H30N2O5/c1-33(2)16-17-36-28-5-3-4-27-30(35)26-15-14-24(18-29(26)38-31(27)28)37-25-13-12-23(32-19-25)11-10-21-6-8-22(20-34)9-7-21/h3-9,12-15,18-19,34H,10-11,16-17,20H2,1-2H3
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n/an/a 550n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501719
PNG
(2-Methyl-4-(3-morpholinopropoxy)-6-phenoxy-9H-xant...)
Show SMILES Cc1cc(OCCCN2CCOCC2)c2oc3cc(Oc4ccccc4)ccc3c(=O)c2c1
Show InChI InChI=1S/C27H27NO5/c1-19-16-23-26(29)22-9-8-21(32-20-6-3-2-4-7-20)18-24(22)33-27(23)25(17-19)31-13-5-10-28-11-14-30-15-12-28/h2-4,6-9,16-18H,5,10-15H2,1H3
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n/an/a 550n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501716
PNG
(4-[3-(Dimethylamino)propoxy]-2-methyl-6-phenoxy-9H...)
Show SMILES CN(C)CCCOc1cc(C)cc2c1oc1cc(Oc3ccccc3)ccc1c2=O
Show InChI InChI=1S/C25H25NO4/c1-17-14-21-24(27)20-11-10-19(29-18-8-5-4-6-9-18)16-22(20)30-25(21)23(15-17)28-13-7-12-26(2)3/h4-6,8-11,14-16H,7,12-13H2,1-3H3
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n/an/a 550n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501694
PNG
(4-(2-(Dimethylamino)ethoxy)-6-((6-methoxypyridin-3...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(CO)nc3)ccc1c2=O
Show InChI InChI=1S/C24H24N2O5/c1-15-10-20-23(28)19-7-6-17(30-18-5-4-16(14-27)25-13-18)12-21(19)31-24(20)22(11-15)29-9-8-26(2)3/h4-7,10-13,27H,8-9,14H2,1-3H3
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n/an/a 550n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501703
PNG
(6-((6-Aminopyridin-3-yl)oxy)-4-(2-(dimethylamino)e...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(N)nc3)ccc1c2=O
Show InChI InChI=1S/C23H23N3O4/c1-14-10-18-22(27)17-6-4-15(29-16-5-7-21(24)25-13-16)12-19(17)30-23(18)20(11-14)28-9-8-26(2)3/h4-7,10-13H,8-9H2,1-3H3,(H2,24,25)
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n/an/a 550n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501721
PNG
(2-Methyl-4-((1-methylpiperidin-4-yl)methoxy)-6-phe...)
Show SMILES Cc1cc(OCC2CCN(CC2)C(=O)OC(C)(C)C)c2oc3cc(Oc4ccccc4)ccc3c(=O)c2c1
Show InChI InChI=1S/C31H33NO6/c1-20-16-25-28(33)24-11-10-23(36-22-8-6-5-7-9-22)18-26(24)37-29(25)27(17-20)35-19-21-12-14-32(15-13-21)30(34)38-31(2,3)4/h5-11,16-18,21H,12-15,19H2,1-4H3
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n/an/a 550n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501727
PNG
(2-Chloro-4-[2-(dimethylamino)ethoxy]-6-({6-[2-(4-m...)
Show SMILES CN(C)CCOc1cc(Cl)cc2c1oc1cc(Oc3ccc(CCc4ccc(CO)cc4)nc3)ccc1c2=O
Show InChI InChI=1S/C31H29ClN2O5/c1-34(2)13-14-37-29-16-22(32)15-27-30(36)26-12-11-24(17-28(26)39-31(27)29)38-25-10-9-23(33-18-25)8-7-20-3-5-21(19-35)6-4-20/h3-6,9-12,15-18,35H,7-8,13-14,19H2,1-2H3
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n/an/a 550n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501717
PNG
(3-((5-(3-(Dimethylamino)propoxy)-7-methyl-9-oxo-9H...)
Show SMILES CN(C)CCCOc1cc(C)cc2c1oc1cc(Oc3cccc(c3)C(=O)Nc3ccccc3)ccc1c2=O
Show InChI InChI=1S/C32H30N2O5/c1-21-17-27-30(35)26-14-13-25(20-28(26)39-31(27)29(18-21)37-16-8-15-34(2)3)38-24-12-7-9-22(19-24)32(36)33-23-10-5-4-6-11-23/h4-7,9-14,17-20H,8,15-16H2,1-3H3,(H,33,36)
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n/an/a 550n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501722
PNG
(2-Methyl-4-(2-(1-methylpiperidin-4-yl)ethoxy)-6-ph...)
Show SMILES Cc1cc(OCCC2CCN(CC2)C(=O)OC(C)(C)C)c2oc3cc(Oc4ccccc4)ccc3c(=O)c2c1
Show InChI InChI=1S/C32H35NO6/c1-21-18-26-29(34)25-11-10-24(37-23-8-6-5-7-9-23)20-27(25)38-30(26)28(19-21)36-17-14-22-12-15-33(16-13-22)31(35)39-32(2,3)4/h5-11,18-20,22H,12-17H2,1-4H3
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n/an/a 550n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501739
PNG
(4-(2-(Dimethylamino)ethoxy)-2-methyl-6-(pyridin-3-...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3cccnc3)ccc1c2=O
Show InChI InChI=1S/C23H22N2O4/c1-15-11-19-22(26)18-7-6-16(28-17-5-4-8-24-14-17)13-20(18)29-23(19)21(12-15)27-10-9-25(2)3/h4-8,11-14H,9-10H2,1-3H3
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n/an/a 550n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501720
PNG
(4-(4-(Dimethylamino)butoxy)-2-methyl-6-phenoxy-9H-...)
Show SMILES Cc1cc(OCCCCBr)c2oc3cc(Oc4ccccc4)ccc3c(=O)c2c1
Show InChI InChI=1S/C24H21BrO4/c1-16-13-20-23(26)19-10-9-18(28-17-7-3-2-4-8-17)15-21(19)29-24(20)22(14-16)27-12-6-5-11-25/h2-4,7-10,13-15H,5-6,11-12H2,1H3
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n/an/a 550n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501690
PNG
(4-[2-(Dimethylamino)ethoxy]-2-methyl-6-phenoxy-9H-...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccccc3)ccc1c2=O
Show InChI InChI=1S/C24H23NO4/c1-16-13-20-23(26)19-10-9-18(28-17-7-5-4-6-8-17)15-21(19)29-24(20)22(14-16)27-12-11-25(2)3/h4-10,13-15H,11-12H2,1-3H3
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n/an/a 550n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501722
PNG
(2-Methyl-4-(2-(1-methylpiperidin-4-yl)ethoxy)-6-ph...)
Show SMILES Cc1cc(OCCC2CCN(CC2)C(=O)OC(C)(C)C)c2oc3cc(Oc4ccccc4)ccc3c(=O)c2c1
Show InChI InChI=1S/C32H35NO6/c1-21-18-26-29(34)25-11-10-24(37-23-8-6-5-7-9-23)20-27(25)38-30(26)28(19-21)36-17-14-22-12-15-33(16-13-22)31(35)39-32(2,3)4/h5-11,18-20,22H,12-17H2,1-4H3
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n/an/a 5.50E+3n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501687
PNG
(5-[2-(Dimethylamino)ethoxy]-3-phenoxy-9H-xanthen-9...)
Show SMILES CN(C)CCOc1cccc2c1oc1cc(Oc3ccccc3)ccc1c2=O
Show InChI InChI=1S/C23H21NO4/c1-24(2)13-14-26-20-10-6-9-19-22(25)18-12-11-17(15-21(18)28-23(19)20)27-16-7-4-3-5-8-16/h3-12,15H,13-14H2,1-2H3
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n/an/a 5.50E+3n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501729
PNG
(N-Cyclopentyl-3-(5-((5-(2-(dimethylamino)ethoxy)-7...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Sc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C31H35N3O4S/c1-20-16-26-30(36)25-12-11-23(18-27(25)38-31(26)28(17-20)37-15-14-34(2)3)39-24-10-8-21(32-19-24)9-13-29(35)33-22-6-4-5-7-22/h8,10-12,16-19,22H,4-7,9,13-15H2,1-3H3,(H,33,35)
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n/an/a 5.50E+3n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501691
PNG
(3-((5-(2-(Dimethylamino)ethoxy)-7-methyl-9-oxo-9H-...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3cccc(c3)C(=O)Nc3ccccc3)ccc1c2=O
Show InChI InChI=1S/C31H28N2O5/c1-20-16-26-29(34)25-13-12-24(19-27(25)38-30(26)28(17-20)36-15-14-33(2)3)37-23-11-7-8-21(18-23)31(35)32-22-9-5-4-6-10-22/h4-13,16-19H,14-15H2,1-3H3,(H,32,35)
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n/an/a 5.50E+3n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501688
PNG
(3-({5-[2-(Dimethylamino)ethoxy]-9-oxo-9H-xanthen-3...)
Show SMILES CN(C)CCOc1cccc2c1oc1cc(Oc3cccc(c3)C(=O)Nc3ccccc3)ccc1c2=O
Show InChI InChI=1S/C30H26N2O5/c1-32(2)16-17-35-26-13-7-12-25-28(33)24-15-14-23(19-27(24)37-29(25)26)36-22-11-6-8-20(18-22)30(34)31-21-9-4-3-5-10-21/h3-15,18-19H,16-17H2,1-2H3,(H,31,34)
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n/an/a 5.50E+3n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501752
PNG
(N-Cyclopentyl-3-(5-((5-(3-(4-isopropylpiperazin-1-...)
Show SMILES CC(C)N1CCN(CCCOc2cc(C)cc3c2oc2cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc2c3=O)CC1
Show InChI InChI=1S/C37H46N4O5/c1-25(2)41-18-16-40(17-19-41)15-6-20-44-34-22-26(3)21-32-36(43)31-13-12-29(23-33(31)46-37(32)34)45-30-11-9-27(38-24-30)10-14-35(42)39-28-7-4-5-8-28/h9,11-13,21-25,28H,4-8,10,14-20H2,1-3H3,(H,39,42)
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n/an/a 5.50E+3n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501731
PNG
(N-Cyclopentyl-3-(5-((7-(2-(dimethylamino)ethoxy)-5...)
Show SMILES CN(C)CCOc1cc(C)c2oc3cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc3c(=O)c2c1
Show InChI InChI=1S/C31H35N3O5/c1-20-16-25(37-15-14-34(2)3)17-27-30(36)26-12-11-23(18-28(26)39-31(20)27)38-24-10-8-21(32-19-24)9-13-29(35)33-22-6-4-5-7-22/h8,10-12,16-19,22H,4-7,9,13-15H2,1-3H3,(H,33,35)
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n/an/a 5.50E+3n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501725
PNG
(2-Chloro-4-[2-(dimethylamino)ethoxy]-6-phenoxy-9H-...)
Show SMILES CN(C)CCOc1cc(Cl)cc2c1oc1cc(Oc3ccccc3)ccc1c2=O
Show InChI InChI=1S/C23H20ClNO4/c1-25(2)10-11-27-21-13-15(24)12-19-22(26)18-9-8-17(14-20(18)29-23(19)21)28-16-6-4-3-5-7-16/h3-9,12-14H,10-11H2,1-2H3
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n/an/a 5.50E+3n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501716
PNG
(4-[3-(Dimethylamino)propoxy]-2-methyl-6-phenoxy-9H...)
Show SMILES CN(C)CCCOc1cc(C)cc2c1oc1cc(Oc3ccccc3)ccc1c2=O
Show InChI InChI=1S/C25H25NO4/c1-17-14-21-24(27)20-11-10-19(29-18-8-5-4-6-9-18)16-22(20)30-25(21)23(15-17)28-13-7-12-26(2)3/h4-6,8-11,14-16H,7,12-13H2,1-3H3
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n/an/a 5.50E+3n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501757
PNG
(N-Cyclopentyl-3-[5-({7-methyl-5-[(1-methyl-4-piper...)
Show SMILES CN1CCC(CC1)Oc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C33H37N3O5/c1-21-17-28-32(38)27-11-10-25(19-29(27)41-33(28)30(18-21)40-24-13-15-36(2)16-14-24)39-26-9-7-22(34-20-26)8-12-31(37)35-23-5-3-4-6-23/h7,9-11,17-20,23-24H,3-6,8,12-16H2,1-2H3,(H,35,37)
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n/an/a 5.50E+3n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (Human))
BDBM501738
PNG
(10-(3-(Dimethylamino)propyl)-2-methyl-6-(phenylthi...)
Show SMILES CN(C)CCCn1c2ccc(C)cc2c(=O)c2ccc(Sc3ccccc3)cc12
Show InChI InChI=1S/C25H26N2OS/c1-18-10-13-23-22(16-18)25(28)21-12-11-20(29-19-8-5-4-6-9-19)17-24(21)27(23)15-7-14-26(2)3/h4-6,8-13,16-17H,7,14-15H2,1-3H3
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n/an/a 5.50E+3n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501720
PNG
(4-(4-(Dimethylamino)butoxy)-2-methyl-6-phenoxy-9H-...)
Show SMILES Cc1cc(OCCCCBr)c2oc3cc(Oc4ccccc4)ccc3c(=O)c2c1
Show InChI InChI=1S/C24H21BrO4/c1-16-13-20-23(26)19-10-9-18(28-17-7-3-2-4-8-17)15-21(19)29-24(20)22(14-16)27-12-6-5-11-25/h2-4,7-10,13-15H,5-6,11-12H2,1H3
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n/an/a 5.50E+3n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501693
PNG
(4-(2-(Dimethylamino)ethoxy)-6-(3-methoxy-4-((4-met...)
Show SMILES COc1cc(Oc2ccc3c(c2)oc2c(OCCN(C)C)cc(C)cc2c3=O)ccc1OCc1ccc(CO)cc1
Show InChI InChI=1S/C33H33NO7/c1-21-15-27-32(36)26-11-9-24(17-29(26)41-33(27)31(16-21)38-14-13-34(2)3)40-25-10-12-28(30(18-25)37-4)39-20-23-7-5-22(19-35)6-8-23/h5-12,15-18,35H,13-14,19-20H2,1-4H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501756
PNG
(N-Cyclopentyl-3-(5-((7-methyl-5-((1-methylpyrrolid...)
Show SMILES CN1CCC(C1)Oc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C32H35N3O5/c1-20-15-27-31(37)26-11-10-23(17-28(26)40-32(27)29(16-20)39-25-13-14-35(2)19-25)38-24-9-7-21(33-18-24)8-12-30(36)34-22-5-3-4-6-22/h7,9-11,15-18,22,25H,3-6,8,12-14,19H2,1-2H3,(H,34,36)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501758
PNG
((R)—N-Cyclopentyl-3-(5-((7-methyl-5-((1-methylpyrr...)
Show SMILES CN1CCC[C@@H]1COc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C33H37N3O5/c1-21-16-28-32(38)27-13-12-25(18-29(27)41-33(28)30(17-21)39-20-24-8-5-15-36(24)2)40-26-11-9-22(34-19-26)10-14-31(37)35-23-6-3-4-7-23/h9,11-13,16-19,23-24H,3-8,10,14-15,20H2,1-2H3,(H,35,37)/t24-/m1/s1
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501696
PNG
(4-(2-(Dimethylamino)ethoxy)-6-((6-((4-methoxybenzy...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(OCc4ccc(CO)cc4)nc3)ccc1c2=O
Show InChI InChI=1S/C31H30N2O6/c1-20-14-26-30(35)25-10-8-23(16-27(25)39-31(26)28(15-20)36-13-12-33(2)3)38-24-9-11-29(32-17-24)37-19-22-6-4-21(18-34)5-7-22/h4-11,14-17,34H,12-13,18-19H2,1-3H3
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501706
PNG
((2-(Dimethylamino)ethoxy)-6-(6-((4-methoxybenzyl)o...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(ccc1c2=O)C(=O)c1ccc(CCc2ccc(CO)cc2)nc1
Show InChI InChI=1S/C33H32N2O5/c1-21-16-28-32(38)27-13-10-24(18-29(27)40-33(28)30(17-21)39-15-14-35(2)3)31(37)25-9-12-26(34-19-25)11-8-22-4-6-23(20-36)7-5-22/h4-7,9-10,12-13,16-19,36H,8,11,14-15,20H2,1-3H3
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501711
PNG
(N-Cyclopentyl-2-((5-((5-(2-(dimethylamino)ethoxy)-...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(nc3)N(CC(=O)NC3CCCC3)C(=O)OC(C)(C)C)ccc1c2=O
Show InChI InChI=1S/C35H42N4O7/c1-22-17-27-32(41)26-13-11-24(19-28(26)45-33(27)29(18-22)43-16-15-38(5)6)44-25-12-14-30(36-20-25)39(34(42)46-35(2,3)4)21-31(40)37-23-9-7-8-10-23/h11-14,17-20,23H,7-10,15-16,21H2,1-6H3,(H,37,40)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501724
PNG
(N-Cyclopentyl-3-(5-((7-methyl-9-oxo-5-(2-(piperidi...)
Show SMILES Cc1cc(OCCN2CCCCC2)c2oc3cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc3c(=O)c2c1
Show InChI InChI=1S/C34H39N3O5/c1-23-19-29-33(39)28-13-12-26(21-30(28)42-34(29)31(20-23)40-18-17-37-15-5-2-6-16-37)41-27-11-9-24(35-22-27)10-14-32(38)36-25-7-3-4-8-25/h9,11-13,19-22,25H,2-8,10,14-18H2,1H3,(H,36,38)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501735
PNG
(3-((5-(2-(Dimethylamino)ethoxy)-7-methyl-9-oxo-9H-...)
Show SMILES CN(C)CCOc1cc(C)cc2c1sc1cc(Oc3cccc(c3)C(=O)Nc3ccccc3)ccc1c2=O
Show InChI InChI=1S/C31H28N2O4S/c1-20-16-26-29(34)25-13-12-24(19-28(25)38-30(26)27(17-20)36-15-14-33(2)3)37-23-11-7-8-21(18-23)31(35)32-22-9-5-4-6-10-22/h4-13,16-19H,14-15H2,1-3H3,(H,32,35)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501739
PNG
(4-(2-(Dimethylamino)ethoxy)-2-methyl-6-(pyridin-3-...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3cccnc3)ccc1c2=O
Show InChI InChI=1S/C23H22N2O4/c1-15-11-19-22(26)18-7-6-16(28-17-5-4-8-24-14-17)13-20(18)29-23(19)21(12-15)27-10-9-25(2)3/h4-8,11-14H,9-10H2,1-3H3
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501745
PNG
(N-Cyclopentyl-3-(5-((7-methyl-9-oxo-5-(2-(4-(2,2,2...)
Show SMILES Cc1cc(OCCN2CCN(CC(F)(F)F)CC2)c2oc3cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc3c(=O)c2c1
Show InChI InChI=1S/C35H39F3N4O5/c1-23-18-29-33(44)28-10-9-26(46-27-8-6-24(39-21-27)7-11-32(43)40-25-4-2-3-5-25)20-30(28)47-34(29)31(19-23)45-17-16-41-12-14-42(15-13-41)22-35(36,37)38/h6,8-10,18-21,25H,2-5,7,11-17,22H2,1H3,(H,40,43)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501762
PNG
(N-Cyclopentyl-3-(5-((7-methyl-5-((1-methylpiperidi...)
Show SMILES CN1CCCC(COc2cc(C)cc3c2oc2cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc2c3=O)C1
Show InChI InChI=1S/C34H39N3O5/c1-22-16-29-33(39)28-13-12-26(18-30(28)42-34(29)31(17-22)40-21-23-6-5-15-37(2)20-23)41-27-11-9-24(35-19-27)10-14-32(38)36-25-7-3-4-8-25/h9,11-13,16-19,23,25H,3-8,10,14-15,20-21H2,1-2H3,(H,36,38)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501694
PNG
(4-(2-(Dimethylamino)ethoxy)-6-((6-methoxypyridin-3...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(CO)nc3)ccc1c2=O
Show InChI InChI=1S/C24H24N2O5/c1-15-10-20-23(28)19-7-6-17(30-18-5-4-16(14-27)25-13-18)12-21(19)31-24(20)22(11-15)29-9-8-26(2)3/h4-7,10-13,27H,8-9,14H2,1-3H3
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501695
PNG
(6-((5,6-Dimethoxypyridin-3-yl)oxy)-4-(2-(dimethyla...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3cnc(CO)c(CO)c3)ccc1c2=O
Show InChI InChI=1S/C25H26N2O6/c1-15-8-20-24(30)19-5-4-17(32-18-10-16(13-28)21(14-29)26-12-18)11-22(19)33-25(20)23(9-15)31-7-6-27(2)3/h4-5,8-12,28-29H,6-7,13-14H2,1-3H3
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501700
PNG
(4-(2-(Dimethylamino)ethoxy)-6-((6-((4-methoxybenzy...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(NCc4ccc(CO)cc4)nc3)ccc1c2=O
Show InChI InChI=1S/C31H31N3O5/c1-20-14-26-30(36)25-10-8-23(16-27(25)39-31(26)28(15-20)37-13-12-34(2)3)38-24-9-11-29(33-18-24)32-17-21-4-6-22(19-35)7-5-21/h4-11,14-16,18,35H,12-13,17,19H2,1-3H3,(H,32,33)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501715
PNG
(N-Cyclopentyl-3-(5-((7-methyl-5-(2-(methylamino)et...)
Show SMILES CN(CCOc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O)C(=O)OC(C)(C)C
Show InChI InChI=1S/C35H41N3O7/c1-22-18-28-32(40)27-14-13-25(43-26-12-10-23(36-21-26)11-15-31(39)37-24-8-6-7-9-24)20-29(27)44-33(28)30(19-22)42-17-16-38(5)34(41)45-35(2,3)4/h10,12-14,18-21,24H,6-9,11,15-17H2,1-5H3,(H,37,39)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501719
PNG
(2-Methyl-4-(3-morpholinopropoxy)-6-phenoxy-9H-xant...)
Show SMILES Cc1cc(OCCCN2CCOCC2)c2oc3cc(Oc4ccccc4)ccc3c(=O)c2c1
Show InChI InChI=1S/C27H27NO5/c1-19-16-23-26(29)22-9-8-21(32-20-6-3-2-4-7-20)18-24(22)33-27(23)25(17-19)31-13-5-10-28-11-14-30-15-12-28/h2-4,6-9,16-18H,5,10-15H2,1H3
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501744
PNG
(N-Cyclopentyl-3-(5-((7-methyl-5-(2-(4-methylpipera...)
Show SMILES CN1CCN(CCOc2cc(C)cc3c2oc2cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc2c3=O)CC1
Show InChI InChI=1S/C34H40N4O5/c1-23-19-29-33(40)28-11-10-26(42-27-9-7-24(35-22-27)8-12-32(39)36-25-5-3-4-6-25)21-30(28)43-34(29)31(20-23)41-18-17-38-15-13-37(2)14-16-38/h7,9-11,19-22,25H,3-6,8,12-18H2,1-2H3,(H,36,39)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501760
PNG
(N-Cyclopentyl-3-(5-((7-methyl-5-((1-methylpiperidi...)
Show SMILES CN1CCCCC1COc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C34H39N3O5/c1-22-17-29-33(39)28-14-13-26(19-30(28)42-34(29)31(18-22)40-21-25-9-5-6-16-37(25)2)41-27-12-10-23(35-20-27)11-15-32(38)36-24-7-3-4-8-24/h10,12-14,17-20,24-25H,3-9,11,15-16,21H2,1-2H3,(H,36,38)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501689
PNG
(5-[2-(Dimethylamino)ethoxy]-3-({6-[2-(4-methoxyphe...)
Show SMILES CN(C)CCOc1cccc2c1oc1cc(Oc3ccc(CCc4ccc(CO)cc4)nc3)ccc1c2=O
Show InChI InChI=1S/C31H30N2O5/c1-33(2)16-17-36-28-5-3-4-27-30(35)26-15-14-24(18-29(26)38-31(27)28)37-25-13-12-23(32-19-25)11-10-21-6-8-22(20-34)9-7-21/h3-9,12-15,18-19,34H,10-11,16-17,20H2,1-2H3
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501701
PNG
(4-(2-(Dimethylamino)ethoxy)-2-methyl-6-((6-((4-(tr...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(NCc4ccc(cc4)C#[F][O](F)F)nc3)ccc1c2=O
Show InChI InChI=1S/C31H28F3N3O5/c1-20-14-26-30(38)25-10-8-23(16-27(25)41-31(26)28(15-20)39-13-12-37(2)3)40-24-9-11-29(36-19-24)35-18-22-6-4-21(5-7-22)17-34-42(32)33/h4-11,14-16,19H,12-13,18H2,1-3H3,(H,35,36)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501702
PNG
(4-(2-(Dimethylamino)ethoxy)-6-((6-(((6-methoxypyri...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(NCc4ccc(CO)nc4)nc3)ccc1c2=O
Show InChI InChI=1S/C30H30N4O5/c1-19-12-25-29(36)24-8-6-22(14-26(24)39-30(25)27(13-19)37-11-10-34(2)3)38-23-7-9-28(33-17-23)32-16-20-4-5-21(18-35)31-15-20/h4-9,12-15,17,35H,10-11,16,18H2,1-3H3,(H,32,33)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501709
PNG
(4-(2-(Dimethylamino)ethoxy)-2-methyl-6-((6-(3-oxo-...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)N4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C30H33N3O5/c1-20-16-25-29(35)24-10-9-22(18-26(24)38-30(25)27(17-20)36-15-14-32(2)3)37-23-8-6-21(31-19-23)7-11-28(34)33-12-4-5-13-33/h6,8-10,16-19H,4-5,7,11-15H2,1-3H3
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501726
PNG
(3-({7-Chloro-5-[2-(dimethylamino)ethoxy]-9-oxo-9H-...)
Show SMILES CN(C)CCOc1cc(Cl)cc2c1oc1cc(Oc3cccc(c3)C(=O)Nc3ccccc3)ccc1c2=O
Show InChI InChI=1S/C30H25ClN2O5/c1-33(2)13-14-36-27-17-20(31)16-25-28(34)24-12-11-23(18-26(24)38-29(25)27)37-22-10-6-7-19(15-22)30(35)32-21-8-4-3-5-9-21/h3-12,15-18H,13-14H2,1-2H3,(H,32,35)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501737
PNG
(N-Cyclopentyl-3-(5-((5-(2-(dimethylamino)ethoxy)-7...)
Show SMILES CN(C)CCOc1cc(C)cc2c1sc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C31H35N3O4S/c1-20-16-26-30(36)25-12-11-23(18-28(25)39-31(26)27(17-20)37-15-14-34(2)3)38-24-10-8-21(32-19-24)9-13-29(35)33-22-6-4-5-7-22/h8,10-12,16-19,22H,4-7,9,13-15H2,1-3H3,(H,33,35)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501740
PNG
(4-(2-(Dimethylamino)ethoxy)-2-methyl-6-((6-(3-(4-m...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)N4CCC(N)CC4)nc3)ccc1c2=O
Show InChI InChI=1S/C31H36N4O5/c1-20-16-26-30(37)25-8-7-23(18-27(25)40-31(26)28(17-20)38-15-14-34(2)3)39-24-6-4-22(33-19-24)5-9-29(36)35-12-10-21(32)11-13-35/h4,6-8,16-19,21H,5,9-15,32H2,1-3H3
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501754
PNG
(N-Cyclopentyl-3-(5-((7-methyl-9-oxo-5-(3-((3S,5R)-...)
Show SMILES C[C@H]1CN(CCCOc2cc(C)cc3c2oc2cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc2c3=O)C[C@@H](C)N1C
Show InChI InChI=1S/C37H46N4O5/c1-24-18-32-36(43)31-14-13-29(45-30-12-10-27(38-21-30)11-15-35(42)39-28-8-5-6-9-28)20-33(31)46-37(32)34(19-24)44-17-7-16-41-22-25(2)40(4)26(3)23-41/h10,12-14,18-21,25-26,28H,5-9,11,15-17,22-23H2,1-4H3,(H,39,42)/t25-,26+
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501755
PNG
(N-Cyclopentyl-3-[5-({7-methyl-5-[3-(4-morpholinyl)...)
Show SMILES Cc1cc(OCCCN2CCOCC2)c2oc3cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc3c(=O)c2c1
Show InChI InChI=1S/C34H39N3O6/c1-23-19-29-33(39)28-11-10-26(42-27-9-7-24(35-22-27)8-12-32(38)36-25-5-2-3-6-25)21-30(28)43-34(29)31(20-23)41-16-4-13-37-14-17-40-18-15-37/h7,9-11,19-22,25H,2-6,8,12-18H2,1H3,(H,36,38)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501759
PNG
((S)—N-Cyclopentyl-3-(5-((7-methyl-5-((1-methylpyrr...)
Show SMILES CN1CCC[C@H]1COc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C33H37N3O5/c1-21-16-28-32(38)27-13-12-25(18-29(27)41-33(28)30(17-21)39-20-24-8-5-15-36(24)2)40-26-11-9-22(34-19-26)10-14-31(37)35-23-6-3-4-7-23/h9,11-13,16-19,23-24H,3-8,10,14-15,20H2,1-2H3,(H,35,37)/t24-/m0/s1
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501761
PNG
(N-Cyclopentyl-3-(5-((7-methyl-5-(2-(1-methylpyrrol...)
Show SMILES CN1CCCC1CCOc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C34H39N3O5/c1-22-18-29-33(39)28-13-12-26(20-30(28)42-34(29)31(19-22)40-17-15-25-8-5-16-37(25)2)41-27-11-9-23(35-21-27)10-14-32(38)36-24-6-3-4-7-24/h9,11-13,18-21,24-25H,3-8,10,14-17H2,1-2H3,(H,36,38)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501698
PNG
(4-(2-(Dimethylamino)ethoxy)-6-((5-methoxy-6-((4-me...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3cnc(OCc4ccc(CO)cc4)c(CO)c3)ccc1c2=O
Show InChI InChI=1S/C32H32N2O7/c1-20-12-27-30(37)26-9-8-24(15-28(26)41-31(27)29(13-20)38-11-10-34(2)3)40-25-14-23(18-36)32(33-16-25)39-19-22-6-4-21(17-35)5-7-22/h4-9,12-16,35-36H,10-11,17-19H2,1-3H3
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501710
PNG
(4-(2-(Dimethylamino)ethoxy)-2-methyl-6-((6-(3-morp...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)N4CCOCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C30H33N3O6/c1-20-16-25-29(35)24-8-7-22(18-26(24)39-30(25)27(17-20)37-15-10-32(2)3)38-23-6-4-21(31-19-23)5-9-28(34)33-11-13-36-14-12-33/h4,6-8,16-19H,5,9-15H2,1-3H3
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501723
PNG
(N-Cyclopentyl-3-(5-((7-methyl-9-oxo-5-(2-(pyrrolid...)
Show SMILES Cc1cc(OCCN2CCCC2)c2oc3cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc3c(=O)c2c1
Show InChI InChI=1S/C33H37N3O5/c1-22-18-28-32(38)27-12-11-25(20-29(27)41-33(28)30(19-22)39-17-16-36-14-4-5-15-36)40-26-10-8-23(34-21-26)9-13-31(37)35-24-6-2-3-7-24/h8,10-12,18-21,24H,2-7,9,13-17H2,1H3,(H,35,37)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501734
PNG
(4-(2-(Dimethylamino)ethoxy)-2-methyl-6-phenoxy-9H-...)
Show SMILES CN(C)CCOc1cc(C)cc2c1sc1cc(Oc3ccccc3)ccc1c2=O
Show InChI InChI=1S/C24H23NO3S/c1-16-13-20-23(26)19-10-9-18(28-17-7-5-4-6-8-17)15-22(19)29-24(20)21(14-16)27-12-11-25(2)3/h4-10,13-15H,11-12H2,1-3H3
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501747
PNG
(N-Cyclopentyl-3-(5-((5-(2-((3S,5R)-3,5-dimethylpip...)
Show SMILES C[C@H]1CN(CCOc2cc(C)cc3c2oc2cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc2c3=O)C[C@@H](C)N1
Show InChI InChI=1S/C35H42N4O5/c1-22-16-30-34(41)29-12-11-27(43-28-10-8-25(36-19-28)9-13-33(40)38-26-6-4-5-7-26)18-31(29)44-35(30)32(17-22)42-15-14-39-20-23(2)37-24(3)21-39/h8,10-12,16-19,23-24,26,37H,4-7,9,13-15,20-21H2,1-3H3,(H,38,40)/t23-,24+
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501749
PNG
(N-Cyclopentyl-3-(5-((5-(3-(dimethylamino)propoxy)-...)
Show SMILES CN(C)CCCOc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C32H37N3O5/c1-21-17-27-31(37)26-13-12-24(19-28(26)40-32(27)29(18-21)38-16-6-15-35(2)3)39-25-11-9-22(33-20-25)10-14-30(36)34-23-7-4-5-8-23/h9,11-13,17-20,23H,4-8,10,14-16H2,1-3H3,(H,34,36)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501697
PNG
(4-(2-(Dimethylamino)ethoxy)-6-((6-((6-methoxypyrid...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(OCc4ccc(CO)nc4)nc3)ccc1c2=O
Show InChI InChI=1S/C30H29N3O6/c1-19-12-25-29(35)24-8-6-22(14-26(24)39-30(25)27(13-19)36-11-10-33(2)3)38-23-7-9-28(32-16-23)37-18-20-4-5-21(17-34)31-15-20/h4-9,12-16,34H,10-11,17-18H2,1-3H3
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501703
PNG
(6-((6-Aminopyridin-3-yl)oxy)-4-(2-(dimethylamino)e...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(N)nc3)ccc1c2=O
Show InChI InChI=1S/C23H23N3O4/c1-14-10-18-22(27)17-6-4-15(29-16-5-7-21(24)25-13-16)12-19(17)30-23(18)20(11-14)28-9-8-26(2)3/h4-7,10-13H,8-9H2,1-3H3,(H2,24,25)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501704
PNG
(4-(2-(Dimethylamino)ethoxy)-6-((6-(4-methoxyphenet...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(CCc4ccc(CO)cc4)nc3)ccc1c2=O
Show InChI InChI=1S/C32H32N2O5/c1-21-16-28-31(36)27-13-12-25(18-29(27)39-32(28)30(17-21)37-15-14-34(2)3)38-26-11-10-24(33-19-26)9-8-22-4-6-23(20-35)7-5-22/h4-7,10-13,16-19,35H,8-9,14-15,20H2,1-3H3
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501705
PNG
(4-(2-(Dimethylamino)ethoxy)-6-((6-methoxypyridin-3...)
Show SMILES COc1cc(C)cc2c1oc1cc(ccc1c2=O)B1OC(C)(C)C(C)(C)O1
Show InChI InChI=1S/C21H23BO5/c1-12-9-15-18(23)14-8-7-13(22-26-20(2,3)21(4,5)27-22)11-16(14)25-19(15)17(10-12)24-6/h7-11H,1-6H3
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501708
PNG
(N-Cyclopentyl-3-(5-((5-(2-(dimethylamino)ethoxy)-7...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C31H35N3O5/c1-20-16-26-30(36)25-12-11-23(18-27(25)39-31(26)28(17-20)37-15-14-34(2)3)38-24-10-8-21(32-19-24)9-13-29(35)33-22-6-4-5-7-22/h8,10-12,16-19,22H,4-7,9,13-15H2,1-3H3,(H,33,35)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501732
PNG
(N-Cyclopentyl-3-(5-((7-(2-(dimethylamino)ethoxy)-5...)
Show SMILES COc1cc(OCCN(C)C)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C31H35N3O6/c1-34(2)14-15-38-24-16-26-30(36)25-12-11-22(17-27(25)40-31(26)28(18-24)37-3)39-23-10-8-20(32-19-23)9-13-29(35)33-21-6-4-5-7-21/h8,10-12,16-19,21H,4-7,9,13-15H2,1-3H3,(H,33,35)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501742
PNG
(N-Cyclopentyl-3-[5-({7-methyl-5-[2-(4-morpholinyl)...)
Show SMILES Cc1cc(OCCN2CCOCC2)c2oc3cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc3c(=O)c2c1
Show InChI InChI=1S/C33H37N3O6/c1-22-18-28-32(38)27-10-9-25(20-29(27)42-33(28)30(19-22)40-17-14-36-12-15-39-16-13-36)41-26-8-6-23(34-21-26)7-11-31(37)35-24-4-2-3-5-24/h6,8-10,18-21,24H,2-5,7,11-17H2,1H3,(H,35,37)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501687
PNG
(5-[2-(Dimethylamino)ethoxy]-3-phenoxy-9H-xanthen-9...)
Show SMILES CN(C)CCOc1cccc2c1oc1cc(Oc3ccccc3)ccc1c2=O
Show InChI InChI=1S/C23H21NO4/c1-24(2)13-14-26-20-10-6-9-19-22(25)18-12-11-17(15-21(18)28-23(19)20)27-16-7-4-3-5-8-16/h3-12,15H,13-14H2,1-2H3
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501713
PNG
(N-(2-(5-((5-(2-(Dimethylamino)ethoxy)-7-methyl-9-o...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(CCNC(=O)N4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C30H34N4O5/c1-20-16-25-28(35)24-9-8-22(18-26(24)39-29(25)27(17-20)37-15-14-33(2)3)38-23-7-6-21(32-19-23)10-11-31-30(36)34-12-4-5-13-34/h6-9,16-19H,4-5,10-15H2,1-3H3,(H,31,36)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501714
PNG
(3-(5-((5-(2-Aminoethoxy)-7-methyl-9-oxo-9H-xanthen...)
Show SMILES Cc1cc(OCCNC(=O)OC(C)(C)C)c2oc3cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc3c(=O)c2c1
Show InChI InChI=1S/C34H39N3O7/c1-21-17-27-31(39)26-13-12-24(42-25-11-9-22(36-20-25)10-14-30(38)37-23-7-5-6-8-23)19-28(26)43-32(27)29(18-21)41-16-15-35-33(40)44-34(2,3)4/h9,11-13,17-20,23H,5-8,10,14-16H2,1-4H3,(H,35,40)(H,37,38)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501728
PNG
(3-(5-((7-Bromo-5-(2-(dimethylamino)ethoxy)-9-oxo-9...)
Show SMILES CN(C)CCOc1cc(Br)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C30H32BrN3O5/c1-34(2)13-14-37-27-16-19(31)15-25-29(36)24-11-10-22(17-26(24)39-30(25)27)38-23-9-7-20(32-18-23)8-12-28(35)33-21-5-3-4-6-21/h7,9-11,15-18,21H,3-6,8,12-14H2,1-2H3,(H,33,35)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501736
PNG
(4-(2-(Dimethylamino)ethoxy)-6-((6-(4-methoxyphenet...)
Show SMILES CN(C)CCOc1cc(C)cc2c1sc1cc(Oc3ccc(CCc4ccc(CO)cc4)nc3)ccc1c2=O
Show InChI InChI=1S/C32H32N2O4S/c1-21-16-28-31(36)27-13-12-25(18-30(27)39-32(28)29(17-21)37-15-14-34(2)3)38-26-11-10-24(33-19-26)9-8-22-4-6-23(20-35)7-5-22/h4-7,10-13,16-19,35H,8-9,14-15,20H2,1-3H3
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501741
PNG
(N-Cyclopentyl-3-(5-((5-(2-(diethylamino)ethoxy)-7-...)
Show SMILES CCN(CC)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C33H39N3O5/c1-4-36(5-2)16-17-39-30-19-22(3)18-28-32(38)27-14-13-25(20-29(27)41-33(28)30)40-26-12-10-23(34-21-26)11-15-31(37)35-24-8-6-7-9-24/h10,12-14,18-21,24H,4-9,11,15-17H2,1-3H3,(H,35,37)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501746
PNG
(N-Cyclopentyl-3-(5-((7-methyl-5-((1-methylpiperidi...)
Show SMILES CN1CCCC(C1)Oc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C33H37N3O5/c1-21-16-28-32(38)27-13-12-24(18-29(27)41-33(28)30(17-21)40-26-8-5-15-36(2)20-26)39-25-11-9-22(34-19-25)10-14-31(37)35-23-6-3-4-7-23/h9,11-13,16-19,23,26H,3-8,10,14-15,20H2,1-2H3,(H,35,37)
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501750
PNG
(N-Cyclopentyl-3-(5-((5-(3-((2R,6S)-2,6-dimethylpip...)
Show SMILES C[C@H]1CCC[C@@H](C)N1CCCOc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C37H45N3O5/c1-24-20-32-36(42)31-16-15-29(44-30-14-12-27(38-23-30)13-17-35(41)39-28-10-4-5-11-28)22-33(31)45-37(32)34(21-24)43-19-7-18-40-25(2)8-6-9-26(40)3/h12,14-16,20-23,25-26,28H,4-11,13,17-19H2,1-3H3,(H,39,41)/t25-,26+
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AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501751
PNG
(N-Cyclopentyl-3-(5-((5-(3-(4-ethylpiperazin-1-yl)p...)
Show SMILES CCN1CCN(CCCOc2cc(C)cc3c2oc2cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc2c3=O)CC1
Show InChI InChI=1S/C36H44N4O5/c1-3-39-16-18-40(19-17-39)15-6-20-43-33-22-25(2)21-31-35(42)30-13-12-28(23-32(30)45-36(31)33)44-29-11-9-26(37-24-29)10-14-34(41)38-27-7-4-5-8-27/h9,11-13,21-24,27H,3-8,10,14-20H2,1-2H3,(H,38,41)
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n/an/a>1.00E+4n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501699
PNG
(4-(2-(Dimethylamino)ethoxy)-2-methyl-6-((6-((6-(tr...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(OCc4ccc(nc4)C(F)(F)F)nc3)ccc1c2=O
Show InChI InChI=1S/C30H26F3N3O5/c1-18-12-23-28(37)22-7-5-20(14-24(22)41-29(23)25(13-18)38-11-10-36(2)3)40-21-6-9-27(35-16-21)39-17-19-4-8-26(34-15-19)30(31,32)33/h4-9,12-16H,10-11,17H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501707
PNG
(3-(5-((5-(2-(Dimethylamino)ethoxy)-7-methyl-9-oxo-...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(ccc1c2=O)C(=O)c1ccc(CCC(=O)Nc2cccnc2)nc1
Show InChI InChI=1S/C32H30N4O5/c1-20-15-26-31(39)25-10-7-21(17-27(25)41-32(26)28(16-20)40-14-13-36(2)3)30(38)22-6-8-23(34-18-22)9-11-29(37)35-24-5-4-12-33-19-24/h4-8,10,12,15-19H,9,11,13-14H2,1-3H3,(H,35,37)
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n/an/a>1.00E+4n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501712
PNG
(N-(2-(5-((5-(2-(Dimethylamino)ethoxy)-7-methyl-9-o...)
Show SMILES CN(C)CCOc1cc(C)cc2c1oc1cc(Oc3ccc(CCNC(=O)C4CCCC4)nc3)ccc1c2=O
Show InChI InChI=1S/C31H35N3O5/c1-20-16-26-29(35)25-11-10-23(18-27(25)39-30(26)28(17-20)37-15-14-34(2)3)38-24-9-8-22(33-19-24)12-13-32-31(36)21-6-4-5-7-21/h8-11,16-19,21H,4-7,12-15H2,1-3H3,(H,32,36)
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n/an/a>1.00E+4n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501730
PNG
(N-Cyclopentyl-3-(5-((7-(2-(dimethylamino)ethoxy)-9...)
Show SMILES CN(C)CCOc1ccc2oc3cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc3c(=O)c2c1
Show InChI InChI=1S/C30H33N3O5/c1-33(2)15-16-36-22-11-13-27-26(17-22)30(35)25-12-10-23(18-28(25)38-27)37-24-9-7-20(31-19-24)8-14-29(34)32-21-5-3-4-6-21/h7,9-13,17-19,21H,3-6,8,14-16H2,1-2H3,(H,32,34)
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n/an/a>1.00E+4n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501743
PNG
(N-Cyclopentyl-3-[5-({5-[2-(diisopropylamino)ethoxy...)
Show SMILES CC(C)N(CCOc1cc(C)cc2c1oc1cc(Oc3ccc(CCC(=O)NC4CCCC4)nc3)ccc1c2=O)C(C)C
Show InChI InChI=1S/C35H43N3O5/c1-22(2)38(23(3)4)16-17-41-32-19-24(5)18-30-34(40)29-14-13-27(20-31(29)43-35(30)32)42-28-12-10-25(36-21-28)11-15-33(39)37-26-8-6-7-9-26/h10,12-14,18-23,26H,6-9,11,15-17H2,1-5H3,(H,37,39)
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n/an/a>1.00E+4n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501748
PNG
(N-Cyclopentyl-3-(5-((7-methyl-9-oxo-5-(2-((3S,5R)-...)
Show SMILES C[C@H]1CN(CCOc2cc(C)cc3c2oc2cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc2c3=O)C[C@@H](C)N1C
Show InChI InChI=1S/C36H44N4O5/c1-23-17-31-35(42)30-13-12-28(44-29-11-9-26(37-20-29)10-14-34(41)38-27-7-5-6-8-27)19-32(30)45-36(31)33(18-23)43-16-15-40-21-24(2)39(4)25(3)22-40/h9,11-13,17-20,24-25,27H,5-8,10,14-16,21-22H2,1-4H3,(H,38,41)/t24-,25+
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n/an/a>1.00E+4n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM501753
PNG
(N-Cyclopentyl-3-(5-((5-(3-((3S,5R)-3,5-dimethylpip...)
Show SMILES C[C@H]1CN(CCCOc2cc(C)cc3c2oc2cc(Oc4ccc(CCC(=O)NC5CCCC5)nc4)ccc2c3=O)C[C@@H](C)N1
Show InChI InChI=1S/C36H44N4O5/c1-23-17-31-35(42)30-13-12-28(44-29-11-9-26(37-20-29)10-14-34(41)39-27-7-4-5-8-27)19-32(30)45-36(31)33(18-23)43-16-6-15-40-21-24(2)38-25(3)22-40/h9,11-13,17-20,24-25,27,38H,4-8,10,14-16,21-22H2,1-3H3,(H,39,41)/t24-,25+
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n/an/a>1.00E+4n/an/an/an/an/an/a



AUCKLAND UNISERVICES LIMITED

US Patent


Assay Description
IC50 values were determined using the Z′-LYTEŽ activity assay, with ATP concentration used at Km app for the specific assay (500 μM ATP fo...


US Patent US11028064 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%