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Patent code US11028066

Compile Data Set for Download or QSAR
Found 97 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501769
PNG
(4-[6-(4-amino-piperidin-1-yl)-4- cyclopropylmethy...)
Show SMILES NC1CCN(CC1)c1nc(cn(CC2CC2)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C20H22FN5O/c21-17-9-14(3-4-15(17)10-22)18-12-26(11-13-1-2-13)20(27)19(24-18)25-7-5-16(23)6-8-25/h3-4,9,12-13,16H,1-2,5-8,11,23H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501773
PNG
(4-[6-(4-aminopiperidin-1-yl)-4- [(4-methoxyphenyl...)
Show SMILES COc1ccc(Cn2cc(nc(N3CCC(N)CC3)c2=O)-c2ccc(cc2)C#N)cc1
Show InChI InChI=1S/C24H25N5O2/c1-31-21-8-4-18(5-9-21)15-29-16-22(19-6-2-17(14-25)3-7-19)27-23(24(29)30)28-12-10-20(26)11-13-28/h2-9,16,20H,10-13,15,26H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501785
PNG
(4-[4-methyl-3-(4-methylphenyl)- 6-{octahydro-1H-p...)
Show SMILES Cc1ccc(cc1)-c1c(nc(N2CCC3CNCC3C2)c(=O)n1C)-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H27N5O/c1-17-3-7-20(8-4-17)24-23(19-9-5-18(13-27)6-10-19)29-25(26(32)30(24)2)31-12-11-21-14-28-15-22(21)16-31/h3-10,21-22,28H,11-12,14-16H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501802
PNG
(4-[6-(4-amino-piperidin-1-yl)-4- (3-hydroxy-propy...)
Show SMILES Cc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)c(=O)n1CCCO)-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H29N5O2/c1-18-3-7-21(8-4-18)24-23(20-9-5-19(17-27)6-10-20)29-25(26(33)31(24)13-2-16-32)30-14-11-22(28)12-15-30/h3-10,22,32H,2,11-16,28H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501815
PNG
(5-[6-(4-amino-piperidin-1-yl)-3- (4-cyclopropyl-p...)
Show SMILES Cn1c(-c2ccc(cc2)C2CC2)c(nc(N2CCC(N)CC2)c1=O)-c1ccc(nc1)C#N
Show InChI InChI=1S/C25H26N6O/c1-30-23(18-6-4-17(5-7-18)16-2-3-16)22(19-8-9-21(14-26)28-15-19)29-24(25(30)32)31-12-10-20(27)11-13-31/h4-9,15-16,20H,2-3,10-13,27H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501817
PNG
(2-fluoro-4-{3-(4-methoxy- phenyl)-4-methyl-5-oxo-...)
Show SMILES COc1ccc(cc1)-c1c(nc(NC[C@H]2CCNC2)c(=O)n1C)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C24H24FN5O2/c1-30-22(16-5-7-19(32-2)8-6-16)21(17-3-4-18(12-26)20(25)11-17)29-23(24(30)31)28-14-15-9-10-27-13-15/h3-8,11,15,27H,9-10,13-14H2,1-2H3,(H,28,29)/t15-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501818
PNG
(5-{3-(4-ethyl-phenyl)-4-methyl-5- oxo-6-[((3S)-py...)
Show SMILES CCc1ccc(cc1)-c1c(nc(NC[C@H]2CCNC2)c(=O)n1C)-c1ccc(nc1)C#N
Show InChI InChI=1S/C24H26N6O/c1-3-16-4-6-18(7-5-16)22-21(19-8-9-20(12-25)27-15-19)29-23(24(31)30(22)2)28-14-17-10-11-26-13-17/h4-9,15,17,26H,3,10-11,13-14H2,1-2H3,(H,28,29)/t17-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501820
PNG
(5-{3-(4-cyclopropyl-phenyl)-4- methyl-5-oxo-6-[((...)
Show SMILES Cn1c(-c2ccc(cc2)C2CC2)c(nc(NC[C@H]2CCNC2)c1=O)-c1ccc(nc1)C#N
Show InChI InChI=1S/C25H26N6O/c1-31-23(19-6-4-18(5-7-19)17-2-3-17)22(20-8-9-21(12-26)28-15-20)30-24(25(31)32)29-14-16-10-11-27-13-16/h4-9,15-17,27H,2-3,10-11,13-14H2,1H3,(H,29,30)/t16-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501828
PNG
(4-[6-(4-Amino-piperidin-1-yl)-4- methyl-3-(6-meth...)
Show SMILES Cc1ccc(cn1)-c1c(nc(N2CCC(N)CC2)c(=O)n1C)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C23H23FN6O/c1-14-3-4-17(13-27-14)21-20(15-5-6-16(12-25)19(24)11-15)28-22(23(31)29(21)2)30-9-7-18(26)8-10-30/h3-6,11,13,18H,7-10,26H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501846
PNG
(4-[5-(4-aminopiperidin-1-yl)-2-(3- fluoro-4-metho...)
Show SMILES COc1ccc(cc1F)-c1c(cc(N2CCC(N)CC2)c(=O)n1C)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C25H24F2N4O2/c1-30-24(16-5-6-23(33-2)21(27)12-16)19(15-3-4-17(14-28)20(26)11-15)13-22(25(30)32)31-9-7-18(29)8-10-31/h3-6,11-13,18H,7-10,29H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501849
PNG
(4-[5-(4-aminopiperidin-1-yl)-1- ethyl-2-(4-methox...)
Show SMILES CCn1c(-c2ccc(OC)cc2)c(cc(N2CCC(N)CC2)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C26H27FN4O2/c1-3-31-25(17-6-8-21(33-2)9-7-17)22(18-4-5-19(16-28)23(27)14-18)15-24(26(31)32)30-12-10-20(29)11-13-30/h4-9,14-15,20H,3,10-13,29H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501777
PNG
(4-[6-(4-amino-piperidin-1-yl)-5- oxo-4-(tetrahydr...)
Show SMILES NC1CCN(CC1)c1nc(cn(CC2CCOCC2)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C22H26FN5O2/c23-19-11-16(1-2-17(19)12-24)20-14-28(13-15-5-9-30-10-6-15)22(29)21(26-20)27-7-3-18(25)4-8-27/h1-2,11,14-15,18H,3-10,13,25H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501784
PNG
(4-[6-(3-aminopiperidin-1-yl)-4- methyl-3-(4-methy...)
Show SMILES Cc1ccc(cc1)-c1c(nc(N2CCCC(N)C2)c(=O)n1C)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H25N5O/c1-16-5-9-19(10-6-16)22-21(18-11-7-17(14-25)8-12-18)27-23(24(30)28(22)2)29-13-3-4-20(26)15-29/h5-12,20H,3-4,13,15,26H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501789
PNG
(4-[6-(4-aminopiperidin-1-yl)-3-(4- ethylphenyl)-4...)
Show SMILES CCc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)c(=O)n1C)-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H27N5O/c1-3-17-4-10-20(11-5-17)23-22(19-8-6-18(16-26)7-9-19)28-24(25(31)29(23)2)30-14-12-21(27)13-15-30/h4-11,21H,3,12-15,27H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501794
PNG
(4-[3-(4-methoxyphenyl)-4-methyl- 5-oxo-6-{[(3R)-p...)
Show SMILES COc1ccc(cc1)-c1c(nc(NC[C@@H]2CCNC2)c(=O)n1C)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H25N5O2/c1-29-22(19-7-9-20(31-2)10-8-19)21(18-5-3-16(13-25)4-6-18)28-23(24(29)30)27-15-17-11-12-26-14-17/h3-10,17,26H,11-12,14-15H2,1-2H3,(H,27,28)/t17-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501795
PNG
(4-{6-(4-aminopiperidin-1-yl)-3-(4- cyclopropylphe...)
Show SMILES Cn1c(-c2ccc(cc2)C2CC2)c(nc(N2CCC(N)CC2)c1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H27N5O/c1-30-24(21-10-8-19(9-11-21)18-6-7-18)23(20-4-2-17(16-27)3-5-20)29-25(26(30)32)31-14-12-22(28)13-15-31/h2-5,8-11,18,22H,6-7,12-15,28H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501799
PNG
(4-[6-(4-amino-piperidin-1-yl)-4- (2-hydroxy-ethyl...)
Show SMILES Cc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)c(=O)n1CCO)-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H27N5O2/c1-17-2-6-20(7-3-17)23-22(19-8-4-18(16-26)5-9-19)28-24(25(32)30(23)14-15-31)29-12-10-21(27)11-13-29/h2-9,21,31H,10-15,27H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501800
PNG
(4-[6-(4-amino-piperidin-1-yl)-3- (4-cyclopropyl-p...)
Show SMILES NC1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2ccc(cc2)C2CC2)n(CCO)c1=O
Show InChI InChI=1S/C27H29N5O2/c28-17-18-1-3-21(4-2-18)24-25(22-9-7-20(8-10-22)19-5-6-19)32(15-16-33)27(34)26(30-24)31-13-11-23(29)12-14-31/h1-4,7-10,19,23,33H,5-6,11-16,29H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501803
PNG
(4-[6-(4-amino-piperidin-1-yl)-4- (2-methoxy-ethyl...)
Show SMILES COCCn1c(-c2ccc(C)cc2)c(nc(N2CCC(N)CC2)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C26H28FN5O2/c1-17-3-5-18(6-4-17)24-23(19-7-8-20(16-28)22(27)15-19)30-25(26(33)32(24)13-14-34-2)31-11-9-21(29)10-12-31/h3-8,15,21H,9-14,29H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501824
PNG
(4-{3-(4-ethoxy-phenyl)-4-methyl- 5-oxo-6-[((3S)-p...)
Show SMILES CCOc1ccc(cc1)-c1c(nc(NC[C@H]2CCNC2)c(=O)n1C)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C25H26FN5O2/c1-3-33-20-8-6-17(7-9-20)23-22(18-4-5-19(13-27)21(26)12-18)30-24(25(32)31(23)2)29-15-16-10-11-28-14-16/h4-9,12,16,28H,3,10-11,14-15H2,1-2H3,(H,29,30)/t16-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501829
PNG
(4-(5-(4-aminopiperidin-1-yl)-2-(4- methoxyphenyl)...)
Show SMILES COc1ccc(cc1)-c1c(cc(N2CCC(N)CC2)c(=O)n1C)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C25H25FN4O2/c1-29-24(16-5-7-20(32-2)8-6-16)21(17-3-4-18(15-27)22(26)13-17)14-23(25(29)31)30-11-9-19(28)10-12-30/h3-8,13-14,19H,9-12,28H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501834
PNG
((S)-4-(2-(4-ethylphenyl)-1- methyl-6-oxo-5-(pyrro...)
Show SMILES CCc1ccc(cc1)-c1c(cc(NC[C@H]2CCNC2)c(=O)n1C)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C26H27FN4O/c1-3-17-4-6-19(7-5-17)25-22(20-8-9-21(14-28)23(27)12-20)13-24(26(32)31(25)2)30-16-18-10-11-29-15-18/h4-9,12-13,18,29-30H,3,10-11,15-16H2,1-2H3/t18-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501836
PNG
((S)-4-(2-(4-cyclopropylphenyl)-1- methyl-6-oxo-5-...)
Show SMILES Cn1c(-c2ccc(cc2)C2CC2)c(cc(NC[C@H]2CCNC2)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C27H27FN4O/c1-32-26(20-6-4-19(5-7-20)18-2-3-18)23(21-8-9-22(14-29)24(28)12-21)13-25(27(32)33)31-16-17-10-11-30-15-17/h4-9,12-13,17-18,30-31H,2-3,10-11,15-16H2,1H3/t17-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501842
PNG
(4-{1-methyl-5-[4- (methylamino)piperidyl]-2-(4- ...)
Show SMILES CNC1CCN(CC1)c1cc(-c2ccc(cc2)C#N)c(-c2ccc(C)cc2)n(C)c1=O
Show InChI InChI=1S/C26H28N4O/c1-18-4-8-21(9-5-18)25-23(20-10-6-19(17-27)7-11-20)16-24(26(31)29(25)3)30-14-12-22(28-2)13-15-30/h4-11,16,22,28H,12-15H2,1-3H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501845
PNG
(4-[5-(4-aminopiperidin-1-yl)-2-(3- fluoro-4-metho...)
Show SMILES COc1ccc(cc1F)-c1c(cc(N2CCC(N)CC2)c(=O)n1C)-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H25FN4O2/c1-29-24(18-7-8-23(32-2)21(26)13-18)20(17-5-3-16(15-27)4-6-17)14-22(25(29)31)30-11-9-19(28)10-12-30/h3-8,13-14,19H,9-12,28H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501766
PNG
(4-[6-(4-aminopiperidin-1-yl)-4-(3- chloro-benzyl)...)
Show SMILES NC1CCN(CC1)c1nc(cn(Cc2cccc(Cl)c2)c1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H22ClN5O/c24-19-3-1-2-17(12-19)14-29-15-21(18-6-4-16(13-25)5-7-18)27-22(23(29)30)28-10-8-20(26)9-11-28/h1-7,12,15,20H,8-11,14,26H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501780
PNG
(4-[4-methyl-3-(4-methylphenyl)- 5-oxo-6-{[(3R)-py...)
Show SMILES Cc1ccc(cc1)-c1c(nc(NC[C@@H]2CCNC2)c(=O)n1C)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H25N5O/c1-16-3-7-20(8-4-16)22-21(19-9-5-17(13-25)6-10-19)28-23(24(30)29(22)2)27-15-18-11-12-26-14-18/h3-10,18,26H,11-12,14-15H2,1-2H3,(H,27,28)/t18-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501792
PNG
(4-[6-(4-aminopiperidin-1-yl)-3-(4- methoxyphenyl)...)
Show SMILES COc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)c(=O)n1C)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H25N5O2/c1-28-22(18-7-9-20(31-2)10-8-18)21(17-5-3-16(15-25)4-6-17)27-23(24(28)30)29-13-11-19(26)12-14-29/h3-10,19H,11-14,26H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501811
PNG
(4-[6-(4-amino-piperidin-1-yl)-4- methyl-3-(6-meth...)
Show SMILES Cc1ccc(cn1)-c1c(nc(N2CCC(N)CC2)c(=O)n1C)-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H24N6O/c1-15-3-6-18(14-26-15)21-20(17-7-4-16(13-24)5-8-17)27-22(23(30)28(21)2)29-11-9-19(25)10-12-29/h3-8,14,19H,9-12,25H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501819
PNG
(4-{3-(4-ethyl-phenyl)-4-methyl-5- oxo-6-[((3S)-py...)
Show SMILES CCc1ccc(cc1)-c1c(nc(NC[C@H]2CCNC2)c(=O)n1C)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C25H26FN5O/c1-3-16-4-6-18(7-5-16)23-22(19-8-9-20(13-27)21(26)12-19)30-24(25(32)31(23)2)29-15-17-10-11-28-14-17/h4-9,12,17,28H,3,10-11,14-15H2,1-2H3,(H,29,30)/t17-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501823
PNG
(4-{3-(4-cyclopropylmethoxy- phenyl)-4-methyl-5-ox...)
Show SMILES Cn1c(-c2ccc(OCC3CC3)cc2)c(nc(NC[C@H]2CCNC2)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C27H28FN5O2/c1-33-25(19-6-8-22(9-7-19)35-16-17-2-3-17)24(20-4-5-21(13-29)23(28)12-20)32-26(27(33)34)31-15-18-10-11-30-14-18/h4-9,12,17-18,30H,2-3,10-11,14-16H2,1H3,(H,31,32)/t18-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501831
PNG
((S)-5-(2-(4-methoxyphenyl)-1- methyl-6-oxo-5-(pyr...)
Show SMILES COc1ccc(cc1)-c1c(cc(NC[C@H]2CCNC2)c(=O)n1C)-c1ccc(nc1)C#N
Show InChI InChI=1S/C24H25N5O2/c1-29-23(17-4-7-20(31-2)8-5-17)21(18-3-6-19(12-25)27-15-18)11-22(24(29)30)28-14-16-9-10-26-13-16/h3-8,11,15-16,26,28H,9-10,13-14H2,1-2H3/t16-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501832
PNG
((S)-2-fluoro-4-(2-(4- methoxyphenyl)-1-methyl-6-o...)
Show SMILES COc1ccc(cc1)-c1c(cc(NC[C@H]2CCNC2)c(=O)n1C)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C25H25FN4O2/c1-30-24(17-5-7-20(32-2)8-6-17)21(18-3-4-19(13-27)22(26)11-18)12-23(25(30)31)29-15-16-9-10-28-14-16/h3-8,11-12,16,28-29H,9-10,14-15H2,1-2H3/t16-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501853
PNG
(4-{5-(4-aminopiperidyl)-2-[6- (dimethylamino)(3-p...)
Show SMILES CN(C)c1ccc(cn1)-c1c(cc(N2CCC(N)CC2)c(=O)n1C)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C25H27FN6O/c1-30(2)23-7-6-18(15-29-23)24-20(16-4-5-17(14-27)21(26)12-16)13-22(25(33)31(24)3)32-10-8-19(28)9-11-32/h4-7,12-13,15,19H,8-11,28H2,1-3H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501765
PNG
(4-[6-(4-aminopiperidin-1-yl)-4- [(2-fluorophenyl)...)
Show SMILES NC1CCN(CC1)c1nc(cn(Cc2ccccc2F)c1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H22FN5O/c24-20-4-2-1-3-18(20)14-29-15-21(17-7-5-16(13-25)6-8-17)27-22(23(29)30)28-11-9-19(26)10-12-28/h1-8,15,19H,9-12,14,26H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501770
PNG
(4-[6-(4-aminopiperidin-1-yl)-4- [(3-fluorophenyl)...)
Show SMILES NC1CCN(CC1)c1nc(cn(Cc2cccc(F)c2)c1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H22FN5O/c24-19-3-1-2-17(12-19)14-29-15-21(18-6-4-16(13-25)5-7-18)27-22(23(29)30)28-10-8-20(26)9-11-28/h1-7,12,15,20H,8-11,14,26H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501775
PNG
(4-[6-(4-aminopiperidin-1-yl)-5- oxo-4-[(1S)-1-phe...)
Show SMILES C[C@@H](c1ccccc1)n1cc(nc(N2CCC(N)CC2)c1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H25N5O/c1-17(19-5-3-2-4-6-19)29-16-22(20-9-7-18(15-25)8-10-20)27-23(24(29)30)28-13-11-21(26)12-14-28/h2-10,16-17,21H,11-14,26H2,1H3/t17-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501776
PNG
(4-[6-(4-amino-piperidin-1-yl)-5- oxo-4-(tetrahydr...)
Show SMILES NC1CCN(CC1)c1nc(cn(CC2CCOC2)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C21H24FN5O2/c22-18-9-15(1-2-16(18)10-23)19-12-27(11-14-5-8-29-13-14)21(28)20(25-19)26-6-3-17(24)4-7-26/h1-2,9,12,14,17H,3-8,11,13,24H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501782
PNG
(4-{4-methyl-6-[4- (methylamino)piperidin-1-yl]-3-...)
Show SMILES CNC1CCN(CC1)c1nc(-c2ccc(cc2)C#N)c(-c2ccc(C)cc2)n(C)c1=O
Show InChI InChI=1S/C25H27N5O/c1-17-4-8-20(9-5-17)23-22(19-10-6-18(16-26)7-11-19)28-24(25(31)29(23)3)30-14-12-21(27-2)13-15-30/h4-11,21,27H,12-15H2,1-3H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501797
PNG
(4-[3-(4-cyclopropylphenyl)-4- methyl-5-oxo-6-{[(3...)
Show SMILES Cn1c(-c2ccc(cc2)C2CC2)c(nc(NC[C@@H]2CCNC2)c1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H27N5O/c1-31-24(22-10-8-20(9-11-22)19-6-7-19)23(21-4-2-17(14-27)3-5-21)30-25(26(31)32)29-16-18-12-13-28-15-18/h2-5,8-11,18-19,28H,6-7,12-13,15-16H2,1H3,(H,29,30)/t18-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501798
PNG
(4-[6-(4-amino-piperidin-1-yl)-4- (2-methoxy-ethyl...)
Show SMILES COCCn1c(-c2ccc(C)cc2)c(nc(N2CCC(N)CC2)c1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H29N5O2/c1-18-3-7-21(8-4-18)24-23(20-9-5-19(17-27)6-10-20)29-25(26(32)31(24)15-16-33-2)30-13-11-22(28)12-14-30/h3-10,22H,11-16,28H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501812
PNG
(4-[6-(4-amino-piperidin-1-yl)-3- (4-cyclopropyl-p...)
Show SMILES Cn1c(-c2ccc(cc2)C2CC2)c(nc(N2CCC(N)CC2)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C26H26FN5O/c1-31-24(18-6-4-17(5-7-18)16-2-3-16)23(19-8-9-20(15-28)22(27)14-19)30-25(26(31)33)32-12-10-21(29)11-13-32/h4-9,14,16,21H,2-3,10-13,29H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501830
PNG
(5-(5-(4-aminopiperidin-1-yl)-2-(4- methoxyphenyl)...)
Show SMILES COc1ccc(cc1)-c1c(cc(N2CCC(N)CC2)c(=O)n1C)-c1ccc(nc1)C#N
Show InChI InChI=1S/C24H25N5O2/c1-28-23(16-4-7-20(31-2)8-5-16)21(17-3-6-19(14-25)27-15-17)13-22(24(28)30)29-11-9-18(26)10-12-29/h3-8,13,15,18H,9-12,26H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501837
PNG
(4-[5-(4-aminopiperidin-1-yl)-1- methyl-2-(4-methy...)
Show SMILES Cc1ccc(cc1)-c1c(cc(N2CCC(N)CC2)c(=O)n1C)-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H26N4O/c1-17-3-7-20(8-4-17)24-22(19-9-5-18(16-26)6-10-19)15-23(25(30)28(24)2)29-13-11-21(27)12-14-29/h3-10,15,21H,11-14,27H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501844
PNG
(4-[5-(4-aminopiperidin-1-yl)-1- ethyl-2-(4-methox...)
Show SMILES CCn1c(-c2ccc(OC)cc2)c(cc(N2CCC(N)CC2)c1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H28N4O2/c1-3-30-25(20-8-10-22(32-2)11-9-20)23(19-6-4-18(17-27)5-7-19)16-24(26(30)31)29-14-12-21(28)13-15-29/h4-11,16,21H,3,12-15,28H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501850
PNG
(2-[3-(4-aminopiperidyl)-5-(4- cyano-3-fluoropheny...)
Show SMILES COc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)c(=O)n1CC(N)=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C25H25FN6O3/c1-35-19-6-4-15(5-7-19)23-22(16-2-3-17(13-27)20(26)12-16)30-24(25(34)32(23)14-21(29)33)31-10-8-18(28)9-11-31/h2-7,12,18H,8-11,14,28H2,1H3,(H2,29,33)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501851
PNG
(3-[3-(4-aminopiperidyl)-5-(4- cyano-3-fluoropheny...)
Show SMILES COc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)c(=O)n1CCC(N)=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C26H27FN6O3/c1-36-20-6-4-16(5-7-20)24-23(17-2-3-18(15-28)21(27)14-17)31-25(32-11-8-19(29)9-12-32)26(35)33(24)13-10-22(30)34/h2-7,14,19H,8-13,29H2,1H3,(H2,30,34)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501771
PNG
(4-[6-(4-aminopiperidin-1-yl)-4- [(4-fluorophenyl)...)
Show SMILES NC1CCN(CC1)c1nc(cn(Cc2ccc(F)cc2)c1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H22FN5O/c24-19-7-3-17(4-8-19)14-29-15-21(18-5-1-16(13-25)2-6-18)27-22(23(29)30)28-11-9-20(26)10-12-28/h1-8,15,20H,9-12,14,26H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501772
PNG
(4-[6-(4-aminopiperidin-1-yl)-4- [(3-methoxyphenyl...)
Show SMILES COc1cccc(Cn2cc(nc(N3CCC(N)CC3)c2=O)-c2ccc(cc2)C#N)c1
Show InChI InChI=1S/C24H25N5O2/c1-31-21-4-2-3-18(13-21)15-29-16-22(19-7-5-17(14-25)6-8-19)27-23(24(29)30)28-11-9-20(26)10-12-28/h2-8,13,16,20H,9-12,15,26H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501781
PNG
(5-[6-(4-aminopiperidin-1-yl)-4- methyl-3-(4-methy...)
Show SMILES Cc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)c(=O)n1C)-c1ccc(nc1)C#N
Show InChI InChI=1S/C23H24N6O/c1-15-3-5-16(6-4-15)21-20(17-7-8-19(13-24)26-14-17)27-22(23(30)28(21)2)29-11-9-18(25)10-12-29/h3-8,14,18H,9-12,25H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501801
PNG
(4-[6-(4-amino-piperidin-1-yl)-4- (3-methoxy-propy...)
Show SMILES COCCCn1c(-c2ccc(C)cc2)c(nc(N2CCC(N)CC2)c1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C27H31N5O2/c1-19-4-8-22(9-5-19)25-24(21-10-6-20(18-28)7-11-21)30-26(31-15-12-23(29)13-16-31)27(33)32(25)14-3-17-34-2/h4-11,23H,3,12-17,29H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501805
PNG
(4-(6-{[((3S)-pyrrolidin-3- yl)methyl]amino}-4-(2-...)
Show SMILES COCCn1c(-c2ccc(C)cc2)c(nc(NC[C@H]2CCNC2)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C26H28FN5O2/c1-17-3-5-19(6-4-17)24-23(20-7-8-21(14-28)22(27)13-20)31-25(26(33)32(24)11-12-34-2)30-16-18-9-10-29-15-18/h3-8,13,18,29H,9-12,15-16H2,1-2H3,(H,30,31)/t18-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501808
PNG
(4-[6-(4-aminopiperidyl)-4-(3- hydroxypropyl)-3-(4...)
Show SMILES Cc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)c(=O)n1CCCO)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C26H28FN5O2/c1-17-3-5-18(6-4-17)24-23(19-7-8-20(16-28)22(27)15-19)30-25(26(34)32(24)11-2-14-33)31-12-9-21(29)10-13-31/h3-8,15,21,33H,2,9-14,29H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501810
PNG
(4-[6-(4-amino-piperidin-1-yl)-4- methyl-5-oxo-3-p...)
Show SMILES Cc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)c(=O)n1C)-c1ccc(cc1F)C#N
Show InChI InChI=1S/C24H24FN5O/c1-15-3-6-17(7-4-15)22-21(19-8-5-16(14-26)13-20(19)25)28-23(24(31)29(22)2)30-11-9-18(27)10-12-30/h3-8,13,18H,9-12,27H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501821
PNG
(4-{3-(4-cyclopropyl-phenyl)-4- methyl-5-oxo-6-[((...)
Show SMILES Cn1c(-c2ccc(cc2)C2CC2)c(nc(NC[C@H]2CCNC2)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C26H26FN5O/c1-32-24(19-6-4-18(5-7-19)17-2-3-17)23(20-8-9-21(13-28)22(27)12-20)31-25(26(32)33)30-15-16-10-11-29-14-16/h4-9,12,16-17,29H,2-3,10-11,14-15H2,1H3,(H,30,31)/t16-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501825
PNG
(2-fluoro-4-[4-methyl-5-oxo-6- [((3S)-pyrrolidin-3...)
Show SMILES Cn1c(-c2ccc(OC(F)(F)F)cc2)c(nc(NC[C@H]2CCNC2)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C24H21F4N5O2/c1-33-21(15-4-6-18(7-5-15)35-24(26,27)28)20(16-2-3-17(11-29)19(25)10-16)32-22(23(33)34)31-13-14-8-9-30-12-14/h2-7,10,14,30H,8-9,12-13H2,1H3,(H,31,32)/t14-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501826
PNG
(2-Fluoro-4-[4-(3-hydroxy-propyl)- 6-(4-methylamin...)
Show SMILES CNC1CCN(CC1)c1nc(-c2ccc(C#N)c(F)c2)c(-c2ccc(C)cc2)n(CCCO)c1=O
Show InChI InChI=1S/C27H30FN5O2/c1-18-4-6-19(7-5-18)25-24(20-8-9-21(17-29)23(28)16-20)31-26(27(35)33(25)12-3-15-34)32-13-10-22(30-2)11-14-32/h4-9,16,22,30,34H,3,10-15H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501833
PNG
((S)-5-(2-(4-ethylphenyl)-1- methyl-6-oxo-5-(pyrro...)
Show SMILES CCc1ccc(cc1)-c1c(cc(NC[C@H]2CCNC2)c(=O)n1C)-c1ccc(nc1)C#N
Show InChI InChI=1S/C25H27N5O/c1-3-17-4-6-19(7-5-17)24-22(20-8-9-21(13-26)28-16-20)12-23(25(31)30(24)2)29-15-18-10-11-27-14-18/h4-9,12,16,18,27,29H,3,10-11,14-15H2,1-2H3/t18-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501835
PNG
((S)-5-(2-(4-cyclopropylphenyl)-1- methyl-6-oxo-5-...)
Show SMILES Cn1c(-c2ccc(cc2)C2CC2)c(cc(NC[C@H]2CCNC2)c1=O)-c1ccc(nc1)C#N
Show InChI InChI=1S/C26H27N5O/c1-31-25(20-6-4-19(5-7-20)18-2-3-18)23(21-8-9-22(13-27)29-16-21)12-24(26(31)32)30-15-17-10-11-28-14-17/h4-9,12,16-18,28,30H,2-3,10-11,14-15H2,1H3/t17-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501839
PNG
(4-[5-(4-aminopiperidin-1-yl)-2-(4- methoxyphenyl)...)
Show SMILES COc1ccc(cc1)-c1c(cc(N2CCC(N)CC2)c(=O)n1C)-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H26N4O2/c1-28-24(19-7-9-21(31-2)10-8-19)22(18-5-3-17(16-26)4-6-18)15-23(25(28)30)29-13-11-20(27)12-14-29/h3-10,15,20H,11-14,27H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501841
PNG
(2-fluoro-4-{2-(4-methoxyphenyl)- 1-methyl-5-[4- ...)
Show SMILES CNC1CCN(CC1)c1cc(-c2ccc(C#N)c(F)c2)c(-c2ccc(OC)cc2)n(C)c1=O
Show InChI InChI=1S/C26H27FN4O2/c1-29-20-10-12-31(13-11-20)24-15-22(18-4-5-19(16-28)23(27)14-18)25(30(2)26(24)32)17-6-8-21(33-3)9-7-17/h4-9,14-15,20,29H,10-13H2,1-3H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501763
PNG
(4-[6-(4-aminopiperidin-1-yl)-4- benzyl-5-oxo-4,5-...)
Show SMILES NC1CCN(CC1)c1nc(cn(Cc2ccccc2)c1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H23N5O/c24-14-17-6-8-19(9-7-17)21-16-28(15-18-4-2-1-3-5-18)23(29)22(26-21)27-12-10-20(25)11-13-27/h1-9,16,20H,10-13,15,25H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501778
PNG
(4-[6-(4-aminopiperidin-1-yl)-4- methyl-3-(4-methy...)
Show SMILES Cc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)c(=O)n1C)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H25N5O/c1-16-3-7-19(8-4-16)22-21(18-9-5-17(15-25)6-10-18)27-23(24(30)28(22)2)29-13-11-20(26)12-14-29/h3-10,20H,11-14,26H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501779
PNG
(4-[4-methyl-3-(4-methylphenyl)- 5-oxo-6-{[(3S)-py...)
Show SMILES Cc1ccc(cc1)-c1c(nc(NC[C@H]2CCNC2)c(=O)n1C)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H25N5O/c1-16-3-7-20(8-4-16)22-21(19-9-5-17(13-25)6-10-19)28-23(24(30)29(22)2)27-15-18-11-12-26-14-18/h3-10,18,26H,11-12,14-15H2,1-2H3,(H,27,28)/t18-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501787
PNG
(4-(6-{decahydropyrrolo[3,4- d]azepin-6-yl}-4-meth...)
Show SMILES Cc1ccc(cc1)-c1c(nc(N2CCC3CNCC3CC2)c(=O)n1C)-c1ccc(cc1)C#N
Show InChI InChI=1S/C27H29N5O/c1-18-3-7-21(8-4-18)25-24(20-9-5-19(15-28)6-10-20)30-26(27(33)31(25)2)32-13-11-22-16-29-17-23(22)12-14-32/h3-10,22-23,29H,11-14,16-17H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501788
PNG
(4-[6-(4-aminopiperidin-1-yl)-4- ethyl-3-(4-methyl...)
Show SMILES CCn1c(-c2ccc(C)cc2)c(nc(N2CCC(N)CC2)c1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H27N5O/c1-3-30-23(20-8-4-17(2)5-9-20)22(19-10-6-18(16-26)7-11-19)28-24(25(30)31)29-14-12-21(27)13-15-29/h4-11,21H,3,12-15,27H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501827
PNG
(2-Fluoro-4-[4-(2-hydroxy-ethyl)- 6-(4-methylamino...)
Show SMILES CNC1CCN(CC1)c1nc(-c2ccc(C#N)c(F)c2)c(-c2ccc(C)cc2)n(CCO)c1=O
Show InChI InChI=1S/C26H28FN5O2/c1-17-3-5-18(6-4-17)24-23(19-7-8-20(16-28)22(27)15-19)30-25(26(34)32(24)13-14-33)31-11-9-21(29-2)10-12-31/h3-8,15,21,29,33H,9-14H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501838
PNG
(4-[5-(4-aminopiperidin-1-yl)-1- methyl-2-(4-methy...)
Show SMILES Cc1ccc(cc1)-c1c(cc(N2CCC(N)CC2)c(=O)n1C)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C25H25FN4O/c1-16-3-5-17(6-4-16)24-21(18-7-8-19(15-27)22(26)13-18)14-23(25(31)29(24)2)30-11-9-20(28)10-12-30/h3-8,13-14,20H,9-12,28H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501854
PNG
(4-{2-[6-(dimethylamino)(3- pyridyl)]-1-methyl-5-[...)
Show SMILES CNC1CCN(CC1)c1cc(-c2ccc(cc2)C#N)c(-c2ccc(nc2)N(C)C)n(C)c1=O
Show InChI InChI=1S/C26H30N6O/c1-28-21-11-13-32(14-12-21)23-15-22(19-7-5-18(16-27)6-8-19)25(31(4)26(23)33)20-9-10-24(29-17-20)30(2)3/h5-10,15,17,21,28H,11-14H2,1-4H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501764
PNG
(4-[6-(4-aminopiperidin-1-yl)-4- [(4-methylphenyl)...)
Show SMILES Cc1ccc(Cn2cc(nc(N3CCC(N)CC3)c2=O)-c2ccc(cc2)C#N)cc1
Show InChI InChI=1S/C24H25N5O/c1-17-2-4-19(5-3-17)15-29-16-22(20-8-6-18(14-25)7-9-20)27-23(24(29)30)28-12-10-21(26)11-13-28/h2-9,16,21H,10-13,15,26H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501774
PNG
(4[6-(4-aminopiperidin-1-yl)-5- oxo-4-[(1R)-1-phen...)
Show SMILES C[C@H](c1ccccc1)n1cc(nc(N2CCC(N)CC2)c1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H25N5O/c1-17(19-5-3-2-4-6-19)29-16-22(20-9-7-18(15-25)8-10-20)27-23(24(29)30)28-13-11-21(26)12-14-28/h2-10,16-17,21H,11-14,26H2,1H3/t17-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501786
PNG
(4-(6-{2,8-diazaspiro[4.5]decan-8- yl}-4-methyl-3-...)
Show SMILES Cc1ccc(cc1)-c1c(nc(N2CCC3(CCNC3)CC2)c(=O)n1C)-c1ccc(cc1)C#N
Show InChI InChI=1S/C27H29N5O/c1-19-3-7-22(8-4-19)24-23(21-9-5-20(17-28)6-10-21)30-25(26(33)31(24)2)32-15-12-27(13-16-32)11-14-29-18-27/h3-10,29H,11-16,18H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501804
PNG
(4-[6-(4-amino-piperidin-1-yl)-4- (2-hydroxy-ethyl...)
Show SMILES Cc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)c(=O)n1CCO)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C25H26FN5O2/c1-16-2-4-17(5-3-16)23-22(18-6-7-19(15-27)21(26)14-18)29-24(25(33)31(23)12-13-32)30-10-8-20(28)9-11-30/h2-7,14,20,32H,8-13,28H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501807
PNG
(4-[6-(4-aminopiperidyl)-4-(3- methoxypropyl)-3(4-...)
Show SMILES COCCCn1c(-c2ccc(C)cc2)c(nc(N2CCC(N)CC2)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C27H30FN5O2/c1-18-4-6-19(7-5-18)25-24(20-8-9-21(17-29)23(28)16-20)31-26(32-13-10-22(30)11-14-32)27(34)33(25)12-3-15-35-2/h4-9,16,22H,3,10-15,30H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501822
PNG
(4-[6-(4-amino-piperidin-1-yl)-4- methyl-3-(1-meth...)
Show SMILES Cn1cnc2cc(ccc12)-c1c(nc(N2CCC(N)CC2)c(=O)n1C)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C25H24FN7O/c1-31-14-29-20-12-16(5-6-21(20)31)23-22(15-3-4-17(13-27)19(26)11-15)30-24(25(34)32(23)2)33-9-7-18(28)8-10-33/h3-6,11-12,14,18H,7-10,28H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501852
PNG
(4-[3-(4-aminopiperidyl)-5-(4- cyano-3-fluoropheny...)
Show SMILES COc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)c(=O)n1CCCC(N)=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C27H29FN6O3/c1-37-21-8-6-17(7-9-21)25-24(18-4-5-19(16-29)22(28)15-18)32-26(33-13-10-20(30)11-14-33)27(36)34(25)12-2-3-23(31)35/h4-9,15,20H,2-3,10-14,30H2,1H3,(H2,31,35)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501783
PNG
(4-[6-(4-amino-4-methylpiperidin- 1-yl)-4-methyl-3...)
Show SMILES Cc1ccc(cc1)-c1c(nc(N2CCC(C)(N)CC2)c(=O)n1C)-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H27N5O/c1-17-4-8-20(9-5-17)22-21(19-10-6-18(16-26)7-11-19)28-23(24(31)29(22)3)30-14-12-25(2,27)13-15-30/h4-11H,12-15,27H2,1-3H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501790
PNG
(4-[3-(4-ethylphenyl)-4-methyl-5- oxo-6-{[(3S)-pyr...)
Show SMILES CCc1ccc(cc1)-c1c(nc(NC[C@H]2CCNC2)c(=O)n1C)-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H27N5O/c1-3-17-4-10-21(11-5-17)23-22(20-8-6-18(14-26)7-9-20)29-24(25(31)30(23)2)28-16-19-12-13-27-15-19/h4-11,19,27H,3,12-13,15-16H2,1-2H3,(H,28,29)/t19-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501791
PNG
(4-[3-(4-ethylphenyl)-4-methyl-5- oxo-6-{[(3R)-pyr...)
Show SMILES CCc1ccc(cc1)-c1c(nc(NC[C@@H]2CCNC2)c(=O)n1C)-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H27N5O/c1-3-17-4-10-21(11-5-17)23-22(20-8-6-18(14-26)7-9-20)29-24(25(31)30(23)2)28-16-19-12-13-27-15-19/h4-11,19,27H,3,12-13,15-16H2,1-2H3,(H,28,29)/t19-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501793
PNG
(4-[3-(4-methoxyphenyl)-4-methyl- 5-oxo-6-{[(3S)-p...)
Show SMILES COc1ccc(cc1)-c1c(nc(NC[C@H]2CCNC2)c(=O)n1C)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H25N5O2/c1-29-22(19-7-9-20(31-2)10-8-19)21(18-5-3-16(13-25)4-6-18)28-23(24(29)30)27-15-17-11-12-26-14-17/h3-10,17,26H,11-12,14-15H2,1-2H3,(H,27,28)/t17-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501796
PNG
(4-[3-(4-cyclopropylphenyl)-4- methyl-5-oxo-6-{[(3...)
Show SMILES Cn1c(-c2ccc(cc2)C2CC2)c(nc(NC[C@H]2CCNC2)c1=O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H27N5O/c1-31-24(22-10-8-20(9-11-22)19-6-7-19)23(21-4-2-17(14-27)3-5-21)30-25(26(31)32)29-16-18-12-13-28-15-18/h2-5,8-11,18-19,28H,6-7,12-13,15-16H2,1H3,(H,29,30)/t18-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501806
PNG
(4-(6-{[((3S)-pyrrolidin-3- yl)methyl]amino}-4-(2-...)
Show SMILES Cc1ccc(cc1)-c1c(nc(NC[C@H]2CCNC2)c(=O)n1CCO)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C25H26FN5O2/c1-16-2-4-18(5-3-16)23-22(19-6-7-20(13-27)21(26)12-19)30-24(25(33)31(23)10-11-32)29-15-17-8-9-28-14-17/h2-7,12,17,28,32H,8-11,14-15H2,1H3,(H,29,30)/t17-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501809
PNG
(4-[6-(4-amino-piperidin-1-yl)-4- methyl-5-oxo-3-p...)
Show SMILES Cc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)c(=O)n1C)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C24H24FN5O/c1-15-3-5-16(6-4-15)22-21(17-7-8-18(14-26)20(25)13-17)28-23(24(31)29(22)2)30-11-9-19(27)10-12-30/h3-8,13,19H,9-12,27H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501813
PNG
(5-[6-(4-amino-piperidin-1-yl)-3- (4-methoxy-pheny...)
Show SMILES COc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)c(=O)n1C)-c1ccc(nc1)C#N
Show InChI InChI=1S/C23H24N6O2/c1-28-21(15-4-7-19(31-2)8-5-15)20(16-3-6-18(13-24)26-14-16)27-22(23(28)30)29-11-9-17(25)10-12-29/h3-8,14,17H,9-12,25H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501814
PNG
(4-[6-(4-amino-piperdin-1-yl)-3- (4-methoxy-phenyl...)
Show SMILES COc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)c(=O)n1C)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C24H24FN5O2/c1-29-22(15-5-7-19(32-2)8-6-15)21(16-3-4-17(14-26)20(25)13-16)28-23(24(29)31)30-11-9-18(27)10-12-30/h3-8,13,18H,9-12,27H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501816
PNG
(5-{3-(4-methoxy-phenyl)-4- methyl-5-oxo-6-[((3S)-...)
Show SMILES COc1ccc(cc1)-c1c(nc(NC[C@H]2CCNC2)c(=O)n1C)-c1ccc(nc1)C#N
Show InChI InChI=1S/C23H24N6O2/c1-29-21(16-4-7-19(31-2)8-5-16)20(17-3-6-18(11-24)26-14-17)28-22(23(29)30)27-13-15-9-10-25-12-15/h3-8,14-15,25H,9-10,12-13H2,1-2H3,(H,27,28)/t15-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501840
PNG
(4-{2-(4-methoxyphenyl)-1- methyl-5-[4- (methylam...)
Show SMILES CNC1CCN(CC1)c1cc(-c2ccc(cc2)C#N)c(-c2ccc(OC)cc2)n(C)c1=O
Show InChI InChI=1S/C26H28N4O2/c1-28-21-12-14-30(15-13-21)24-16-23(19-6-4-18(17-27)5-7-19)25(29(2)26(24)31)20-8-10-22(32-3)11-9-20/h4-11,16,21,28H,12-15H2,1-3H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501843
PNG
(4-[5-(4-aminopiperidin-1-yl)-1- (cyclopropylmethy...)
Show SMILES COc1ccc(cc1)-c1c(cc(N2CCC(N)CC2)c(=O)n1CC1CC1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C28H30N4O2/c1-34-24-10-8-22(9-11-24)27-25(21-6-4-19(17-29)5-7-21)16-26(31-14-12-23(30)13-15-31)28(33)32(27)18-20-2-3-20/h4-11,16,20,23H,2-3,12-15,18,30H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501847
PNG
(4-[5-(4-aminopiperidin-1-yl)-1- (cyclopropylmethy...)
Show SMILES COc1ccc(cc1)-c1c(cc(N2CCC(N)CC2)c(=O)n1CC1CC1)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C28H29FN4O2/c1-35-23-8-6-19(7-9-23)27-24(20-4-5-21(16-30)25(29)14-20)15-26(32-12-10-22(31)11-13-32)28(34)33(27)17-18-2-3-18/h4-9,14-15,18,22H,2-3,10-13,17,31H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501848
PNG
(2-fluoro-4-[2-(3-fluoro-4- methoxyphenyl)-1-methy...)
Show SMILES CNC1CCN(CC1)c1cc(-c2ccc(C#N)c(F)c2)c(-c2ccc(OC)c(F)c2)n(C)c1=O
Show InChI InChI=1S/C26H26F2N4O2/c1-30-19-8-10-32(11-9-19)23-14-20(16-4-5-18(15-29)21(27)12-16)25(31(2)26(23)33)17-6-7-24(34-3)22(28)13-17/h4-7,12-14,19,30H,8-11H2,1-3H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501767
PNG
(4-[6-(4-amino-piperidin-1-yl)-4- methyl-5-oxo-4,5...)
Show SMILES Cn1cc(nc(N2CCC(N)CC2)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C17H18FN5O/c1-22-10-15(11-2-3-12(9-19)14(18)8-11)21-16(17(22)24)23-6-4-13(20)5-7-23/h2-3,8,10,13H,4-7,20H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501859
PNG
(3-(4-aminopiperidin-1-yl)-5-[4-(difluoromethyl)phe...)
Show SMILES Cc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)c(=O)n1C)-c1ccc(cc1)C(F)F
Show InChI InChI=1S/C24H26F2N4O/c1-15-3-5-17(6-4-15)21-20(16-7-9-18(10-8-16)22(25)26)28-23(24(31)29(21)2)30-13-11-19(27)12-14-30/h3-10,19,22H,11-14,27H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501768
PNG
(4-[6-(4-Amino-piperidin-1-yl)-4- ethyl-5-oxo-4,5-...)
Show SMILES CCn1cc(nc(N2CCC(N)CC2)c1=O)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C18H20FN5O/c1-2-23-11-16(12-3-4-13(10-20)15(19)9-12)22-17(18(23)25)24-7-5-14(21)6-8-24/h3-4,9,11,14H,2,5-8,21H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501858
PNG
(3-(4-aminopiperidin-1-yl)-1-methyl-6-(4-methylphen...)
Show SMILES Cc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)c(=O)n1C)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H25F3N4O/c1-15-3-5-17(6-4-15)21-20(16-7-9-18(10-8-16)24(25,26)27)29-22(23(32)30(21)2)31-13-11-19(28)12-14-31/h3-10,19H,11-14,28H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501857
PNG
(3-(4-aminopiperidin-1-yl)-5-[4-(hydroxymethyl)phen...)
Show SMILES Cc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)c(=O)n1C)-c1ccc(CO)cc1
Show InChI InChI=1S/C24H28N4O2/c1-16-3-7-19(8-4-16)22-21(18-9-5-17(15-29)6-10-18)26-23(24(30)27(22)2)28-13-11-20(25)12-14-28/h3-10,20,29H,11-15,25H2,1-2H3
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n/an/a 5.50E+3n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501855
PNG
(4-[6-(4-aminopiperidin-1-yl)-4-methyl-3-(4- methyl...)
Show SMILES Cc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)c(=O)n1C)-c1ccc(cc1)C(N)=O
Show InChI InChI=1S/C24H27N5O2/c1-15-3-5-17(6-4-15)21-20(16-7-9-18(10-8-16)22(26)30)27-23(24(31)28(21)2)29-13-11-19(25)12-14-29/h3-10,19H,11-14,25H2,1-2H3,(H2,26,30)
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n/an/a 5.50E+3n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM501856
PNG
(5-(4-acetylphenyl)-3-(4-aminopiperidin-1-yl)-1-met...)
Show SMILES CC(=O)c1ccc(cc1)-c1nc(N2CCC(N)CC2)c(=O)n(C)c1-c1ccc(C)cc1
Show InChI InChI=1S/C25H28N4O2/c1-16-4-6-20(7-5-16)23-22(19-10-8-18(9-11-19)17(2)30)27-24(25(31)28(23)3)29-14-12-21(26)13-15-29/h4-11,21H,12-15,26H2,1-3H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US11028066 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%