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Patent code US11028080

Compile Data Set for Download or QSAR
Found 44 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501984
PNG
(US11028080, No. 40)
Show SMILES CC(C)(C(N)=O)c1nc(Cl)c(Nc2ncc(c(NCC(F)F)n2)C(F)(F)F)s1
Show InChI InChI=1S/C14H14ClF5N6OS/c1-13(2,10(21)27)11-24-7(15)9(28-11)26-12-23-3-5(14(18,19)20)8(25-12)22-4-6(16)17/h3,6H,4H2,1-2H3,(H2,21,27)(H2,22,23,25,26)
PDB

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n/an/a<30n/an/an/an/an/an/a



DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501990
PNG
(US11028080, No. 46 | US11028080, No. 47)
Show SMILES CCNc1nc(Nc2sc(nc2Cl)C2(C)CCN(C)C2=O)ncc1C(F)(F)F
Show InChI InChI=1S/C16H18ClF3N6OS/c1-4-21-10-8(16(18,19)20)7-22-14(24-10)25-11-9(17)23-12(28-11)15(2)5-6-26(3)13(15)27/h7H,4-6H2,1-3H3,(H2,21,22,24,25)
PDB

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n/an/a<30n/an/an/an/an/an/a



DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501990
PNG
(US11028080, No. 46 | US11028080, No. 47)
Show SMILES CCNc1nc(Nc2sc(nc2Cl)C2(C)CCN(C)C2=O)ncc1C(F)(F)F
Show InChI InChI=1S/C16H18ClF3N6OS/c1-4-21-10-8(16(18,19)20)7-22-14(24-10)25-11-9(17)23-12(28-11)15(2)5-6-26(3)13(15)27/h7H,4-6H2,1-3H3,(H2,21,22,24,25)
PDB

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n/an/a<30n/an/an/an/an/an/a



DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501999
PNG
(US11028080, No. 59 | US11028080, No. 60)
Show SMILES CNc1nc(Nc2sc(nc2C2CC2)C2(C)CCNC2=O)ncc1C(F)(F)F
Show InChI InChI=1S/C17H19F3N6OS/c1-16(5-6-22-13(16)27)14-24-10(8-3-4-8)12(28-14)26-15-23-7-9(17(18,19)20)11(21-2)25-15/h7-8H,3-6H2,1-2H3,(H,22,27)(H2,21,23,25,26)
PDB

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n/an/a<30n/an/an/an/an/an/a



DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501949
PNG
(US11028080, No. 2)
Show SMILES CNc1nc(Nc2sc(nc2C)C2(CC2)C#N)ncc1C(F)(F)F
Show InChI InChI=1S/C14H13F3N6S/c1-7-10(24-11(21-7)13(6-18)3-4-13)23-12-20-5-8(14(15,16)17)9(19-2)22-12/h5H,3-4H2,1-2H3,(H2,19,20,22,23)
PDB

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n/an/a<30n/an/an/an/an/an/a



DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501964
PNG
(US11028080, No. 15)
Show SMILES CCNc1nc(Nc2cn(Cc3ccn(C)n3)c(C#N)c2C)ncc1C(F)(F)F
Show InChI InChI=1S/C18H19F3N8/c1-4-23-16-13(18(19,20)21)8-24-17(26-16)25-14-10-29(15(7-22)11(14)2)9-12-5-6-28(3)27-12/h5-6,8,10H,4,9H2,1-3H3,(H2,23,24,25,26)
PDB

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n/an/a<30n/an/an/an/an/an/a



DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501980
PNG
(US11028080, No. 36)
Show SMILES CNc1nc(Nc2sc(nc2Cl)C(C)(C)C#N)ncc1C(F)(F)F
Show InChI InChI=1S/C13H12ClF3N6S/c1-12(2,5-18)10-21-7(14)9(24-10)23-11-20-4-6(13(15,16)17)8(19-3)22-11/h4H,1-3H3,(H2,19,20,22,23)
PDB

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n/an/a<30n/an/an/an/an/an/a



DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501986
PNG
(US11028080, No. 42 | US11028080, No. 43)
Show SMILES CNc1nc(Nc2sc(nc2Cl)C2(C)CCNC2=O)ncc1C(F)(F)F
Show InChI InChI=1S/C14H14ClF3N6OS/c1-13(3-4-20-10(13)25)11-22-7(15)9(26-11)24-12-21-5-6(14(16,17)18)8(19-2)23-12/h5H,3-4H2,1-2H3,(H,20,25)(H2,19,21,23,24)
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n/an/a<30n/an/an/an/an/an/a



DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501986
PNG
(US11028080, No. 42 | US11028080, No. 43)
Show SMILES CNc1nc(Nc2sc(nc2Cl)C2(C)CCNC2=O)ncc1C(F)(F)F
Show InChI InChI=1S/C14H14ClF3N6OS/c1-13(3-4-20-10(13)25)11-22-7(15)9(26-11)24-12-21-5-6(14(16,17)18)8(19-2)23-12/h5H,3-4H2,1-2H3,(H,20,25)(H2,19,21,23,24)
PDB

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n/an/a<30n/an/an/an/an/an/a



DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501994
PNG
(US11028080, No. 50)
Show SMILES CCNc1nc(Nc2sc(nc2Cl)C(C)(C)C#N)ncc1C(F)(F)F
Show InChI InChI=1S/C14H14ClF3N6S/c1-4-20-9-7(14(16,17)18)5-21-12(23-9)24-10-8(15)22-11(25-10)13(2,3)6-19/h5H,4H2,1-3H3,(H2,20,21,23,24)
PDB

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n/an/a<30n/an/an/an/an/an/a



DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501962
PNG
(US11028080, No. 11 | US11028080, No. 33)
Show SMILES CCNc1nc(Nc2sc(nc2C)C(=O)N2CC3CCC(C2)O3)ncc1C(F)(F)F
Show InChI InChI=1S/C18H21F3N6O2S/c1-3-22-13-12(18(19,20)21)6-23-17(25-13)26-14-9(2)24-15(30-14)16(28)27-7-10-4-5-11(8-27)29-10/h6,10-11H,3-5,7-8H2,1-2H3,(H2,22,23,25,26)
PDB

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n/an/a<30n/an/an/an/an/an/a



DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501977
PNG
(US11028080, No. 32)
Show SMILES CCNc1nc(Nc2sc(nc2C)C2(CC2)C#N)ncc1C(F)(F)F
Show InChI InChI=1S/C15H15F3N6S/c1-3-20-10-9(15(16,17)18)6-21-13(23-10)24-11-8(2)22-12(25-11)14(7-19)4-5-14/h6H,3-5H2,1-2H3,(H2,20,21,23,24)
PDB

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n/an/a<30n/an/an/an/an/an/a



DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501979
PNG
(US11028080, No. 34)
Show SMILES CC(C)(C(N)=O)c1nc(Cl)c(Nc2ncc(c(NC3CC3)n2)C(F)(F)F)s1
Show InChI InChI=1S/C15H16ClF3N6OS/c1-14(2,11(20)26)12-23-8(16)10(27-12)25-13-21-5-7(15(17,18)19)9(24-13)22-6-3-4-6/h5-6H,3-4H2,1-2H3,(H2,20,26)(H2,21,22,24,25)
PDB

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n/an/a<30n/an/an/an/an/an/a



DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501981
PNG
(US11028080, No. 37)
Show SMILES CCNc1nc(Nc2sc(nc2Cl)C(C)(C)C(N)=O)ncc1C(F)(F)F
Show InChI InChI=1S/C14H16ClF3N6OS/c1-4-20-8-6(14(16,17)18)5-21-12(23-8)24-9-7(15)22-11(26-9)13(2,3)10(19)25/h5H,4H2,1-3H3,(H2,19,25)(H2,20,21,23,24)
PDB

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n/an/a<30n/an/an/an/an/an/a



DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501982
PNG
(US11028080, No. 38)
Show SMILES CCNc1nc(Nc2sc(nc2Cl)C(C)(C)C(N)=O)ncc1Br
Show InChI InChI=1S/C13H16BrClN6OS/c1-4-17-8-6(14)5-18-12(20-8)21-9-7(15)19-11(23-9)13(2,3)10(16)22/h5H,4H2,1-3H3,(H2,16,22)(H2,17,18,20,21)
PDB

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n/an/a<30n/an/an/an/an/an/a



DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501983
PNG
(US11028080, No. 39)
Show SMILES COc1nc(Nc2sc(nc2Cl)C(C)(C)C(N)=O)ncc1Br
Show InChI InChI=1S/C12H13BrClN5O2S/c1-12(2,9(15)20)10-17-6(14)8(22-10)19-11-16-4-5(13)7(18-11)21-3/h4H,1-3H3,(H2,15,20)(H,16,18,19)
PDB

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n/an/a<30n/an/an/an/an/an/a



DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501992
PNG
(US11028080, No. 48 | US11028080, No. 49)
Show SMILES COc1nc(Nc2sc(nc2Cl)C2(C)CCNC2=O)ncc1Br
Show InChI InChI=1S/C13H13BrClN5O2S/c1-13(3-4-16-10(13)21)11-18-7(15)9(23-11)20-12-17-5-6(14)8(19-12)22-2/h5H,3-4H2,1-2H3,(H,16,21)(H,17,19,20)
PDB

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n/an/a<30n/an/an/an/an/an/a



DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501963
PNG
(US11028080, No. 14)
Show SMILES CNc1nc(Nc2cn(C)c(C#N)c2C)ncc1C(F)(F)F
Show InChI InChI=1S/C13H13F3N6/c1-7-9(6-22(3)10(7)4-17)20-12-19-5-8(13(14,15)16)11(18-2)21-12/h5-6H,1-3H3,(H2,18,19,20,21)
PDB

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n/an/a<30n/an/an/an/an/an/a



DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501973
PNG
(US11028080, No. 28)
Show SMILES CCNc1nc(Nc2sc(nc2C)C(=O)NC)ncc1C(F)(F)F
Show InChI InChI=1S/C13H15F3N6OS/c1-4-18-8-7(13(14,15)16)5-19-12(21-8)22-10-6(2)20-11(24-10)9(23)17-3/h5H,4H2,1-3H3,(H,17,23)(H2,18,19,21,22)
PDB

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DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501962
PNG
(US11028080, No. 11 | US11028080, No. 33)
Show SMILES CCNc1nc(Nc2sc(nc2C)C(=O)N2CC3CCC(C2)O3)ncc1C(F)(F)F
Show InChI InChI=1S/C18H21F3N6O2S/c1-3-22-13-12(18(19,20)21)6-23-17(25-13)26-14-9(2)24-15(30-14)16(28)27-7-10-4-5-11(8-27)29-10/h6,10-11H,3-5,7-8H2,1-2H3,(H2,22,23,25,26)
PDB

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n/an/a<30n/an/an/an/an/an/a



DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501992
PNG
(US11028080, No. 48 | US11028080, No. 49)
Show SMILES COc1nc(Nc2sc(nc2Cl)C2(C)CCNC2=O)ncc1Br
Show InChI InChI=1S/C13H13BrClN5O2S/c1-13(3-4-16-10(13)21)11-18-7(15)9(23-11)20-12-17-5-6(14)8(19-12)22-2/h5H,3-4H2,1-2H3,(H,16,21)(H,17,19,20)
PDB

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n/an/a<30n/an/an/an/an/an/a



DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501995
PNG
(US11028080, No. 51 | US11028080, No. 52)
Show SMILES CCNc1nc(Nc2sc(nc2C2CC2)C2(C)CCNC2=O)ncc1C(F)(F)F
Show InChI InChI=1S/C18H21F3N6OS/c1-3-22-12-10(18(19,20)21)8-24-16(26-12)27-13-11(9-4-5-9)25-15(29-13)17(2)6-7-23-14(17)28/h8-9H,3-7H2,1-2H3,(H,23,28)(H2,22,24,26,27)
PDB

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US Patent
n/an/a<30n/an/an/an/an/an/a



DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501999
PNG
(US11028080, No. 59 | US11028080, No. 60)
Show SMILES CNc1nc(Nc2sc(nc2C2CC2)C2(C)CCNC2=O)ncc1C(F)(F)F
Show InChI InChI=1S/C17H19F3N6OS/c1-16(5-6-22-13(16)27)14-24-10(8-3-4-8)12(28-14)26-15-23-7-9(17(18,19)20)11(21-2)25-15/h7-8H,3-6H2,1-2H3,(H,22,27)(H2,21,23,25,26)
PDB

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US Patent
n/an/a<30n/an/an/an/an/an/a



DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501967
PNG
(US11028080, No. 22)
Show SMILES CNc1nc(Nc2sc(nc2C)C(C)(C)C(N)=O)ncc1C(F)(F)F
Show InChI InChI=1S/C14H17F3N6OS/c1-6-9(25-11(21-6)13(2,3)10(18)24)23-12-20-5-7(14(15,16)17)8(19-4)22-12/h5H,1-4H3,(H2,18,24)(H2,19,20,22,23)
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DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501969
PNG
(US11028080, No. 24)
Show SMILES CCNc1nc(Nc2sc(nc2C)C(=O)N2CCOCC2)ncc1C(F)(F)F
Show InChI InChI=1S/C16H19F3N6O2S/c1-3-20-11-10(16(17,18)19)8-21-15(23-11)24-12-9(2)22-13(28-12)14(26)25-4-6-27-7-5-25/h8H,3-7H2,1-2H3,(H2,20,21,23,24)
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DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501976
PNG
(US11028080, No. 31)
Show SMILES Cc1nc(sc1Nc1ncc(c(n1)C1CC1)C(F)(F)F)C(C)(C)c1nnn(C)n1
Show InChI InChI=1S/C17H19F3N8S/c1-8-12(29-14(22-8)16(2,3)13-25-27-28(4)26-13)24-15-21-7-10(17(18,19)20)11(23-15)9-5-6-9/h7,9H,5-6H2,1-4H3,(H,21,23,24)
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DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501997
PNG
(US11028080, No. 53 | US11028080, No. 54)
Show SMILES COc1nc(Nc2sc(nc2C2CC2)C2(C)CCNC2=O)ncc1Br
Show InChI InChI=1S/C16H18BrN5O2S/c1-16(5-6-18-13(16)23)14-20-10(8-3-4-8)12(25-14)22-15-19-7-9(17)11(21-15)24-2/h7-8H,3-6H2,1-2H3,(H,18,23)(H,19,21,22)
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DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501876
PNG
(US11028080, No. 1)
Show SMILES Cc1nc(sc1Nc1ncc(c(n1)C1CC1)C(F)(F)F)C(C)(C)c1nc[nH]n1
Show InChI InChI=1S/C17H18F3N7S/c1-8-12(28-14(24-8)16(2,3)13-22-7-23-27-13)26-15-21-6-10(17(18,19)20)11(25-15)9-4-5-9/h6-7,9H,4-5H2,1-3H3,(H,21,25,26)(H,22,23,27)
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DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501966
PNG
(US11028080, No. 17)
Show SMILES CNc1nc(Nc2sc(nc2C)C(C)(C)C#N)ncc1C(F)(F)F
Show InChI InChI=1S/C14H15F3N6S/c1-7-10(24-11(21-7)13(2,3)6-18)23-12-20-5-8(14(15,16)17)9(19-4)22-12/h5H,1-4H3,(H2,19,20,22,23)
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DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501968
PNG
(US11028080, No. 23)
Show SMILES CNc1nc(Nc2sc(nc2C)C2(C)CCN(C)C2=O)ncc1C(F)(F)F
Show InChI InChI=1S/C16H19F3N6OS/c1-8-11(27-12(22-8)15(2)5-6-25(4)13(15)26)24-14-21-7-9(16(17,18)19)10(20-3)23-14/h7H,5-6H2,1-4H3,(H2,20,21,23,24)
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DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501970
PNG
(US11028080, No. 25)
Show SMILES CNc1nc(Nc2sc(nc2Cl)C(C)(C)C(N)=O)ncc1C(F)(F)F
Show InChI InChI=1S/C13H14ClF3N6OS/c1-12(2,9(18)24)10-21-6(14)8(25-10)23-11-20-4-5(13(15,16)17)7(19-3)22-11/h4H,1-3H3,(H2,18,24)(H2,19,20,22,23)
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DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501972
PNG
(US11028080, No. 27)
Show SMILES CCNc1nc(Nc2sc(nc2C)C#N)ncc1C(F)(F)F
Show InChI InChI=1S/C12H11F3N6S/c1-3-17-9-7(12(13,14)15)5-18-11(20-9)21-10-6(2)19-8(4-16)22-10/h5H,3H2,1-2H3,(H2,17,18,20,21)
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DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501974
PNG
(US11028080, No. 29)
Show SMILES Cc1nc(sc1Nc1ncc(c(NC2CC2)n1)C(F)(F)F)C(C)(C)C(N)=O
Show InChI InChI=1S/C16H19F3N6OS/c1-7-11(27-13(22-7)15(2,3)12(20)26)25-14-21-6-9(16(17,18)19)10(24-14)23-8-4-5-8/h6,8H,4-5H2,1-3H3,(H2,20,26)(H2,21,23,24,25)
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DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501975
PNG
(US11028080, No. 30)
Show SMILES Cc1nc(sc1Nc1ncc(c(n1)C1CC1)C(F)(F)F)C(C)(C)C(N)=O
Show InChI InChI=1S/C16H18F3N5OS/c1-7-11(26-13(22-7)15(2,3)12(20)25)24-14-21-6-9(16(17,18)19)10(23-14)8-4-5-8/h6,8H,4-5H2,1-3H3,(H2,20,25)(H,21,23,24)
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DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501985
PNG
(US11028080, No. 41)
Show SMILES CC(C)(C(N)=O)c1nc(Cl)c(Nc2ncc(Br)c(NC3CC3)n2)s1
Show InChI InChI=1S/C14H16BrClN6OS/c1-14(2,11(17)23)12-20-8(16)10(24-12)22-13-18-5-7(15)9(21-13)19-6-3-4-6/h5-6H,3-4H2,1-2H3,(H2,17,23)(H2,18,19,21,22)
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DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501988
PNG
(US11028080, No. 44 | US11028080, No. 45)
Show SMILES CNc1nc(Nc2sc(nc2Cl)C2(C)CCN(C)C2=O)ncc1C(F)(F)F
Show InChI InChI=1S/C15H16ClF3N6OS/c1-14(4-5-25(3)12(14)26)11-22-8(16)10(27-11)24-13-21-6-7(15(17,18)19)9(20-2)23-13/h6H,4-5H2,1-3H3,(H2,20,21,23,24)
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DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501995
PNG
(US11028080, No. 51 | US11028080, No. 52)
Show SMILES CCNc1nc(Nc2sc(nc2C2CC2)C2(C)CCNC2=O)ncc1C(F)(F)F
Show InChI InChI=1S/C18H21F3N6OS/c1-3-22-12-10(18(19,20)21)8-24-16(26-12)27-13-11(9-4-5-9)25-15(29-13)17(2)6-7-23-14(17)28/h8-9H,3-7H2,1-2H3,(H,23,28)(H2,22,24,26,27)
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DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501997
PNG
(US11028080, No. 53 | US11028080, No. 54)
Show SMILES COc1nc(Nc2sc(nc2C2CC2)C2(C)CCNC2=O)ncc1Br
Show InChI InChI=1S/C16H18BrN5O2S/c1-16(5-6-18-13(16)23)14-20-10(8-3-4-8)12(25-14)22-15-19-7-9(17)11(21-15)24-2/h7-8H,3-6H2,1-2H3,(H,18,23)(H,19,21,22)
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DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM502001
PNG
(US11028080, No. 61)
Show SMILES CNc1nc(Nc2sc(nc2C2CC2)C(C)(C)C#N)ncc1C(F)(F)F
Show InChI InChI=1S/C16H17F3N6S/c1-15(2,7-20)13-23-10(8-4-5-8)12(26-13)25-14-22-6-9(16(17,18)19)11(21-3)24-14/h6,8H,4-5H2,1-3H3,(H2,21,22,24,25)
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DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501960
PNG
(US11028080, No. 3)
Show SMILES Cc1nc(sc1Nc1ncc(c(n1)C1CC1)C(F)(F)F)C1(CC1)c1nc[nH]n1
Show InChI InChI=1S/C17H16F3N7S/c1-8-12(28-14(24-8)16(4-5-16)13-22-7-23-27-13)26-15-21-6-10(17(18,19)20)11(25-15)9-2-3-9/h6-7,9H,2-5H2,1H3,(H,21,25,26)(H,22,23,27)
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DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501961
PNG
(US11028080, No. 10)
Show SMILES CCNc1nc(Nc2sc(nc2C)C(=O)N2CCC(F)(F)C2)ncc1C(F)(F)F
Show InChI InChI=1S/C16H17F5N6OS/c1-3-22-10-9(16(19,20)21)6-23-14(25-10)26-11-8(2)24-12(29-11)13(28)27-5-4-15(17,18)7-27/h6H,3-5,7H2,1-2H3,(H2,22,23,25,26)
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DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501965
PNG
(US11028080, No. 16)
Show SMILES CCNc1nc(Nc2cn(c(C#N)c2C)S(C)(=O)=O)ncc1C(F)(F)F
Show InChI InChI=1S/C14H15F3N6O2S/c1-4-19-12-9(14(15,16)17)6-20-13(22-12)21-10-7-23(26(3,24)25)11(5-18)8(10)2/h6-7H,4H2,1-3H3,(H2,19,20,21,22)
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DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501971
PNG
(US11028080, No. 26)
Show SMILES CCNc1nc(Nc2sc(nc2C)C(C)(C)C(N)=O)ncc1C(F)(F)F
Show InChI InChI=1S/C15H19F3N6OS/c1-5-20-9-8(15(16,17)18)6-21-13(23-9)24-10-7(2)22-12(26-10)14(3,4)11(19)25/h6H,5H2,1-4H3,(H2,19,25)(H2,20,21,23,24)
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DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM501988
PNG
(US11028080, No. 44 | US11028080, No. 45)
Show SMILES CNc1nc(Nc2sc(nc2Cl)C2(C)CCN(C)C2=O)ncc1C(F)(F)F
Show InChI InChI=1S/C15H16ClF3N6OS/c1-14(4-5-25(3)12(14)26)11-22-8(16)10(27-11)24-13-21-6-7(15(17,18)19)9(20-2)23-13/h6H,4-5H2,1-3H3,(H2,20,21,23,24)
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DENALI THERAPEUTICS INC.

US Patent


Assay Description
Materials:LRRK2 G2019S enzymeSubstrate (LRRKtide)ATPTR-FRET dilution bufferpLRRKtide antibody384-well assay plateDMSOEnzyme reaction conditions50 mM ...


US Patent US11028080 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%