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Patent code US11028083

Compile Data Set for Download or QSAR
Found 163 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502138
PNG
(US11028083, Example 100b)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1[C@H]1CC[C@@]2(CCCOC2)CC1
Show InChI InChI=1S/C21H36N4O/c1-22-11-13-24(2)15-18-20(19-5-3-12-25(19)23-18)17-6-9-21(10-7-17)8-4-14-26-16-21/h17,22H,3-16H2,1-2H3/t17-,21-
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n/an/a 22n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502122
PNG
(US11028083, Example 91)
Show SMILES CCOCC1(COCC)CCC(CC1)c1c(CN(C)CCN)nn2CC(F)(F)Cc12
Show InChI InChI=1S/C22H38F2N4O2/c1-4-29-15-21(16-30-5-2)8-6-17(7-9-21)20-18(13-27(3)11-10-25)26-28-14-22(23,24)12-19(20)28/h17H,4-16,25H2,1-3H3
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502103
PNG
(US11028083, Example 79b | US11028083, Example 80b)
Show SMILES CNCCN(C)Cc1nn2CC(F)(F)Cc2c1[C@H]1CC[C@@]2(CCCOC2)CC1
Show InChI InChI=1S/C21H34F2N4O/c1-24-9-10-26(2)13-17-19(18-12-21(22,23)14-27(18)25-17)16-4-7-20(8-5-16)6-3-11-28-15-20/h16,24H,3-15H2,1-2H3/t16-,20-
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502116
PNG
(US11028083, Example 87b)
Show SMILES CNCCN(C)Cc1nn2CC(F)(F)Cc2c1[C@H]1CC[C@@]2(CC1)COCC(C)(C)C2
Show InChI InChI=1S/C23H38F2N4O/c1-21(2)13-22(16-30-15-21)7-5-17(6-8-22)20-18(12-28(4)10-9-26-3)27-29-14-23(24,25)11-19(20)29/h17,26H,5-16H2,1-4H3/t17-,22-
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502127
PNG
(US11028083, Example 94b)
Show SMILES CCOC[C@]1(CC)CC[C@@H](CC1)c1c(CN(C)CCNC)nn2CCCc12
Show InChI InChI=1S/C22H40N4O/c1-5-22(17-27-6-2)11-9-18(10-12-22)21-19(16-25(4)15-13-23-3)24-26-14-7-8-20(21)26/h18,23H,5-17H2,1-4H3/t18-,22+
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n/an/a 27n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502129
PNG
(US11028083, Example 95b)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1[C@H]1CC[C@@]2(CCCOC2)CC1
Show InChI InChI=1S/C21H36N4O/c1-22-11-13-24(2)15-18-20(19-5-3-12-25(19)23-18)17-6-9-21(10-7-17)8-4-14-26-16-21/h17,22H,3-16H2,1-2H3/t17-,21-
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502140
PNG
(US11028083, Example 101b)
Show SMILES CC[C@@]1(COCC(F)(F)F)CC[C@@H](CC1)c1c(CN(C)CCNC)nn2CCCc12
Show InChI InChI=1S/C22H37F3N4O/c1-4-21(15-30-16-22(23,24)25)9-7-17(8-10-21)20-18(14-28(3)13-11-26-2)27-29-12-5-6-19(20)29/h17,26H,4-16H2,1-3H3/t17-,21+
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n/an/a 29n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502120
PNG
(US11028083, Example 89b)
Show SMILES CNCCN(C)Cc1nn2CC(F)(F)Cc2c1[C@H]1CC[C@@]2(CCCC(C)(C)O2)CC1
Show InChI InChI=1S/C23H38F2N4O/c1-21(2)8-5-9-22(30-21)10-6-17(7-11-22)20-18(15-28(4)13-12-26-3)27-29-16-23(24,25)14-19(20)29/h17,26H,5-16H2,1-4H3/t17-,22-
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502057
PNG
(N1-((3-(4,4-dimethyl- cyclohexyl)-5,6- dihydro-4H-...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1C1CCC(C)(C)CC1
Show InChI InChI=1S/C19H34N4/c1-19(2)9-7-15(8-10-19)18-16(14-22(4)13-11-20-3)21-23-12-5-6-17(18)23/h15,20H,5-14H2,1-4H3
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502114
PNG
(US11028083, Example 86b)
Show SMILES CNCCN(C)Cc1nn2CC(F)(F)Cc2c1[C@H]1CC[C@]2(CC1)CCC(C)(C)OC2
Show InChI InChI=1S/C23H38F2N4O/c1-21(2)9-10-22(16-30-21)7-5-17(6-8-22)20-18(14-28(4)12-11-26-3)27-29-15-23(24,25)13-19(20)29/h17,26H,5-16H2,1-4H3/t17-,22-
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502128
PNG
(US11028083, Example 95a)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1[C@H]1CC[C@]2(CCCOC2)CC1
Show InChI InChI=1S/C21H36N4O/c1-22-11-13-24(2)15-18-20(19-5-3-12-25(19)23-18)17-6-9-21(10-7-17)8-4-14-26-16-21/h17,22H,3-16H2,1-2H3/t17-,21+
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502009
PNG
(US11028083, Example 5b)
Show SMILES CCOCC1(CC)CC[C@@H](CC1)c1c(CN(C)CCNC)nn2CC(F)(F)Cc12
Show InChI InChI=1S/C22H38F2N4O/c1-5-21(16-29-6-2)9-7-17(8-10-21)20-18(14-27(4)12-11-25-3)26-28-15-22(23,24)13-19(20)28/h17,25H,5-16H2,1-4H3/t17-,21?
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502074
PNG
(US11028083, Example 65a)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1[C@H]1CCC(C)(COC)CC1
Show InChI InChI=1S/C20H36N4O/c1-20(15-25-4)9-7-16(8-10-20)19-17(14-23(3)13-11-21-2)22-24-12-5-6-18(19)24/h16,21H,5-15H2,1-4H3/t16-,20?
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502107
PNG
(US11028083, Example 82a | US11028083, Example 82b)
Show SMILES CC[C@]1(COCC(F)(F)F)CC[C@@H](CC1)c1c(CN(C)CCNC)nn2CCOCc12
Show InChI InChI=1S/C22H37F3N4O2/c1-4-21(15-31-16-22(23,24)25)7-5-17(6-8-21)20-18(13-28(3)10-9-26-2)27-29-11-12-30-14-19(20)29/h17,26H,4-16H2,1-3H3/t17-,21-
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502131
PNG
(US11028083, Example 96b)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1[C@H]1CC[C@@]2(CC(C)(C)CO2)CC1
Show InChI InChI=1S/C22H38N4O/c1-21(2)15-22(27-16-21)9-7-17(8-10-22)20-18(14-25(4)13-11-23-3)24-26-12-5-6-19(20)26/h17,23H,5-16H2,1-4H3/t17-,22-
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502103
PNG
(US11028083, Example 79b | US11028083, Example 80b)
Show SMILES CNCCN(C)Cc1nn2CC(F)(F)Cc2c1[C@H]1CC[C@@]2(CCCOC2)CC1
Show InChI InChI=1S/C21H34F2N4O/c1-24-9-10-26(2)13-17-19(18-12-21(22,23)14-27(18)25-17)16-4-7-20(8-5-16)6-3-11-28-15-20/h16,24H,3-15H2,1-2H3/t16-,20-
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502019
PNG
(N1,N2-dimethyl-N1-((3- (spiro[5.5]undecan-3- yl)-5...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1C1CCC2(CCCCC2)CC1
Show InChI InChI=1S/C22H38N4/c1-23-14-16-25(2)17-19-21(20-7-6-15-26(20)24-19)18-8-12-22(13-9-18)10-4-3-5-11-22/h18,23H,3-17H2,1-2H3
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n/an/a 37n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502143
PNG
(US11028083, Example 103b)
Show SMILES CC[C@@]1(COCC(F)(F)F)CC[C@@H](CC1)c1c(CN(C)CCNC)nn2CC(F)(F)Cc12
Show InChI InChI=1S/C22H35F5N4O/c1-4-20(14-32-15-22(25,26)27)7-5-16(6-8-20)19-17(12-30(3)10-9-28-2)29-31-13-21(23,24)11-18(19)31/h16,28H,4-15H2,1-3H3/t16-,20+
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502055
PNG
(N1,N2-dimethyl-N1-((3- (spiro[4.5]decan-8-yl)- 5,6...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1C1CCC2(CCCC2)CC1
Show InChI InChI=1S/C21H36N4/c1-22-13-15-24(2)16-18-20(19-6-5-14-25(19)23-18)17-7-11-21(12-8-17)9-3-4-10-21/h17,22H,3-16H2,1-2H3
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n/an/a 39n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502075
PNG
(US11028083, Example 65b)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1[C@H]1CCC(C)(COC)CC1
Show InChI InChI=1S/C20H36N4O/c1-20(15-25-4)9-7-16(8-10-20)19-17(14-23(3)13-11-21-2)22-24-12-5-6-18(19)24/h16,21H,5-15H2,1-4H3/t16-,20?
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502115
PNG
(US11028083, Example 87a)
Show SMILES CNCCN(C)Cc1nn2CC(F)(F)Cc2c1[C@H]1CC[C@]2(CC1)COCC(C)(C)C2
Show InChI InChI=1S/C23H38F2N4O/c1-21(2)13-22(16-30-15-21)7-5-17(6-8-22)20-18(12-28(4)10-9-26-3)27-29-14-23(24,25)11-19(20)29/h17,26H,5-16H2,1-4H3/t17-,22+
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502113
PNG
(US11028083, Example 86a)
Show SMILES CNCCN(C)Cc1nn2CC(F)(F)Cc2c1[C@H]1CC[C@@]2(CC1)CCC(C)(C)OC2
Show InChI InChI=1S/C23H38F2N4O/c1-21(2)9-10-22(16-30-21)7-5-17(6-8-22)20-18(14-28(4)12-11-26-3)27-29-15-23(24,25)13-19(20)29/h17,26H,5-16H2,1-4H3/t17-,22+
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n/an/a 41n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502022
PNG
(Ethyl 1-methyl-4-(2- ((methyl(2-(methyl- amino)eth...)
Show SMILES CCOC(=O)C1(C)CCC(CC1)c1c(CN(C)CCNC)nn2CCCc12
Show InChI InChI=1S/C21H36N4O2/c1-5-27-20(26)21(2)10-8-16(9-11-21)19-17(15-24(4)14-12-22-3)23-25-13-6-7-18(19)25/h16,22H,5-15H2,1-4H3
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502102
PNG
(US11028083, Example 79a | US11028083, Example 80a)
Show SMILES CNCCN(C)Cc1nn2CC(F)(F)Cc2c1[C@H]1CC[C@]2(CCCOC2)CC1
Show InChI InChI=1S/C21H34F2N4O/c1-24-9-10-26(2)13-17-19(18-12-21(22,23)14-27(18)25-17)16-4-7-20(8-5-16)6-3-11-28-15-20/h16,24H,3-15H2,1-2H3/t16-,20+
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502136
PNG
(N1-((3-(4,4-bis(methoxy- methyl)cyclohexyl)-5,5- d...)
Show SMILES CNCCN(C)Cc1nn2CC(F)(F)Cc2c1C1CCC(COC)(COC)CC1
Show InChI InChI=1S/C21H36F2N4O2/c1-24-9-10-26(2)12-17-19(18-11-21(22,23)13-27(18)25-17)16-5-7-20(8-6-16,14-28-3)15-29-4/h16,24H,5-15H2,1-4H3
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502126
PNG
(US11028083, Example 94a)
Show SMILES CCOC[C@@]1(CC)CC[C@@H](CC1)c1c(CN(C)CCNC)nn2CCCc12
Show InChI InChI=1S/C22H40N4O/c1-5-22(17-27-6-2)11-9-18(10-12-22)21-19(16-25(4)15-13-23-3)24-26-14-7-8-20(21)26/h18,23H,5-17H2,1-4H3/t18-,22-
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502038
PNG
(N1-((3-(4,4-bis(ethoxy- methyl)cyclohexyl)- 5,6,7,...)
Show SMILES CCOCC1(COCC)CCC(CC1)c1c(CN(C)CCNC)nc2CCOCn12
Show InChI InChI=1S/C23H42N4O3/c1-5-28-16-23(17-29-6-2)10-7-19(8-11-23)22-20(15-26(4)13-12-24-3)25-21-9-14-30-18-27(21)22/h19,24H,5-18H2,1-4H3
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502017
PNG
(N1-((3-cyclohexyl-5,6- dihydro-4H-pyrrolo- [1,2-b]...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1C1CCCCC1
Show InChI InChI=1S/C17H30N4/c1-18-10-12-20(2)13-15-17(14-7-4-3-5-8-14)16-9-6-11-21(16)19-15/h14,18H,3-13H2,1-2H3
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502028
PNG
(N1-((3-cyclohexyl-6,7- dihydro-4H-pyrazolo- [5,1-c...)
Show SMILES CNCCN(C)Cc1nn2CCOCc2c1C1CCCCC1
Show InChI InChI=1S/C17H30N4O/c1-18-8-9-20(2)12-15-17(14-6-4-3-5-7-14)16-13-22-11-10-21(16)19-15/h14,18H,3-13H2,1-2H3
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502070
PNG
(US11028083, Example 63a)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1[C@H]1CCC2(CCN(C)C2=O)CC1
Show InChI InChI=1S/C21H35N5O/c1-22-11-14-24(2)15-17-19(18-5-4-12-26(18)23-17)16-6-8-21(9-7-16)10-13-25(3)20(21)27/h16,22H,4-15H2,1-3H3/t16-,21?
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502130
PNG
(US11028083, Example 96a)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1[C@H]1CC[C@]2(CC(C)(C)CO2)CC1
Show InChI InChI=1S/C22H38N4O/c1-21(2)15-22(27-16-21)9-7-17(8-10-22)20-18(14-25(4)13-11-23-3)24-26-12-5-6-19(20)26/h17,23H,5-16H2,1-4H3/t17-,22+
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502148
PNG
(US11028083, Example 107a)
Show SMILES CNCCN(C)Cc1nn2CCOCc2c1[C@H]1CC[C@@]2(CC1)CCC(C)(C)CO2
Show InChI InChI=1S/C23H40N4O2/c1-22(2)9-10-23(29-17-22)7-5-18(6-8-23)21-19(15-26(4)12-11-24-3)25-27-13-14-28-16-20(21)27/h18,24H,5-17H2,1-4H3/t18-,23+
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502101
PNG
(US11028083, Example 78b)
Show SMILES CNCCN(C)Cc1nn2CC(F)(F)Cc2c1[C@H]1CC[C@@]2(CC(C)(C)CO2)CC1
Show InChI InChI=1S/C22H36F2N4O/c1-20(2)13-21(29-15-20)7-5-16(6-8-21)19-17(12-27(4)10-9-25-3)26-28-14-22(23,24)11-18(19)28/h16,25H,5-15H2,1-4H3/t16-,21-
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502135
PNG
(US11028083, Example 98b)
Show SMILES CNCCN(C)Cc1nn2CCOCc2c1[C@H]1CC[C@@]2(CCCCO2)CC1
Show InChI InChI=1S/C21H36N4O2/c1-22-10-11-24(2)15-18-20(19-16-26-14-12-25(19)23-18)17-5-8-21(9-6-17)7-3-4-13-27-21/h17,22H,3-16H2,1-2H3/t17-,21-
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502049
PNG
(N1-((3-(3-oxaspiro- [5.5]undecan-9-yl)- 5,6-dihydr...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1[C@H]1CCC2(CCOCC2)CC1
Show InChI InChI=1S/C21H36N4O/c1-22-11-13-24(2)16-18-20(19-4-3-12-25(19)23-18)17-5-7-21(8-6-17)9-14-26-15-10-21/h17,22H,3-16H2,1-2H3
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502084
PNG
(US11028083, Example 70a)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1[C@H]1CCC2(CCCO2)CC1
Show InChI InChI=1S/C20H34N4O/c1-21-11-13-23(2)15-17-19(18-5-3-12-24(18)22-17)16-6-9-20(10-7-16)8-4-14-25-20/h16,21H,3-15H2,1-2H3/t16-,20?
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502008
PNG
(US11028083, Example 5a)
Show SMILES CCOCC1(CC)CC[C@@H](CC1)c1c(CN(C)CCNC)nn2CC(F)(F)Cc12
Show InChI InChI=1S/C22H38F2N4O/c1-5-21(16-29-6-2)9-7-17(8-10-21)20-18(14-27(4)12-11-25-3)26-28-15-22(23,24)13-19(20)28/h17,25H,5-16H2,1-4H3/t17-,21?
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502033
PNG
(2-Benzyl-8-(2- ((methyl(2-(methyl- amino)ethyl)ami...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1C1CCC2(CCN(Cc3ccccc3)C2=O)CC1
Show InChI InChI=1S/C27H39N5O/c1-28-15-18-30(2)20-23-25(24-9-6-16-32(24)29-23)22-10-12-27(13-11-22)14-17-31(26(27)33)19-21-7-4-3-5-8-21/h3-5,7-8,22,28H,6,9-20H2,1-2H3
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502118
PNG
(US11028083, Example 88b)
Show SMILES CNCCN(C)Cc1nn2CC(F)(F)Cc2c1[C@H]1CC[C@]2(CC1)CCC(C)(C)CO2
Show InChI InChI=1S/C23H38F2N4O/c1-21(2)9-10-22(30-16-21)7-5-17(6-8-22)20-18(14-28(4)12-11-26-3)27-29-15-23(24,25)13-19(20)29/h17,26H,5-16H2,1-4H3/t17-,22-
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502014
PNG
(US11028083, Example 9a)
Show SMILES CNCCN(C)Cc1nn2CCOCc2c1[C@H]1CC[C@]2(CCN(Cc3ccccc3)C2=O)CC1
Show InChI InChI=1S/C27H39N5O2/c1-28-13-15-30(2)19-23-25(24-20-34-17-16-32(24)29-23)22-8-10-27(11-9-22)12-14-31(26(27)33)18-21-6-4-3-5-7-21/h3-7,22,28H,8-20H2,1-2H3/t22-,27+
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502012
PNG
(US11028083, Example 8a)
Show SMILES CNCCN(C)Cc1nn2CCOCc2c1[C@H]1CC[C@](C)(COC)CC1
Show InChI InChI=1S/C20H36N4O2/c1-20(15-25-4)7-5-16(6-8-20)19-17(13-23(3)10-9-21-2)22-24-11-12-26-14-18(19)24/h16,21H,5-15H2,1-4H3/t16-,20-
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502097
PNG
(US11028083, Example 76b)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1[C@H]1CCC2(CCCCO2)CC1
Show InChI InChI=1S/C21H36N4O/c1-22-12-14-24(2)16-18-20(19-6-5-13-25(19)23-18)17-7-10-21(11-8-17)9-3-4-15-26-21/h17,22H,3-16H2,1-2H3/t17-,21?
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502093
PNG
(US11028083, Example 74b)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1[C@H]1CCC2(CCCOC2)CC1
Show InChI InChI=1S/C21H36N4O/c1-22-11-13-24(2)15-18-20(19-5-3-12-25(19)23-18)17-6-9-21(10-7-17)8-4-14-26-16-21/h17,22H,3-16H2,1-2H3/t17-,21?
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502085
PNG
(US11028083, Example 70b)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1[C@H]1CCC2(CCCO2)CC1
Show InChI InChI=1S/C20H34N4O/c1-21-11-13-23(2)15-17-19(18-5-3-12-24(18)22-17)16-6-9-20(10-7-16)8-4-14-25-20/h16,21H,3-15H2,1-2H3/t16-,20?
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502133
PNG
(US11028083, Example 97b)
Show SMILES CNCCN(C)Cc1nn2CCOCc2c1[C@H]1CC[C@@]2(CC(C)(C)CO2)CC1
Show InChI InChI=1S/C22H38N4O2/c1-21(2)15-22(28-16-21)7-5-17(6-8-22)20-18(13-25(4)10-9-23-3)24-26-11-12-27-14-19(20)26/h17,23H,5-16H2,1-4H3/t17-,22-
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502013
PNG
(US11028083, Example 8b)
Show SMILES CNCCN(C)Cc1nn2CCOCc2c1[C@H]1CC[C@@](C)(COC)CC1
Show InChI InChI=1S/C20H36N4O2/c1-20(15-25-4)7-5-16(6-8-20)19-17(13-23(3)10-9-21-2)22-24-11-12-26-14-18(19)24/h16,21H,5-15H2,1-4H3/t16-,20+
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502125
PNG
(US11028083, Example 93b)
Show SMILES CNCCN(C)Cc1nn2CCOCc2c1[C@H]1CC[C@@]2(CCCOC2)CC1
Show InChI InChI=1S/C21H36N4O2/c1-22-9-10-24(2)14-18-20(19-15-26-13-11-25(19)23-18)17-4-7-21(8-5-17)6-3-12-27-16-21/h17,22H,3-16H2,1-2H3/t17-,21-
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502137
PNG
(US11028083, Example 100a)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1[C@H]1CC[C@]2(CCCOC2)CC1
Show InChI InChI=1S/C21H36N4O/c1-22-11-13-24(2)15-18-20(19-5-3-12-25(19)23-18)17-6-9-21(10-7-17)8-4-14-26-16-21/h17,22H,3-16H2,1-2H3/t17-,21+
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502139
PNG
(US11028083, Example 101a)
Show SMILES CC[C@]1(COCC(F)(F)F)CC[C@@H](CC1)c1c(CN(C)CCNC)nn2CCCc12
Show InChI InChI=1S/C22H37F3N4O/c1-4-21(15-30-16-22(23,24)25)9-7-17(8-10-21)20-18(14-28(3)13-11-26-2)27-29-12-5-6-19(20)29/h17,26H,4-16H2,1-3H3/t17-,21-
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502095
PNG
(US11028083, Example 75b)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1[C@H]1CCC2(CCC(C)(C)O2)CC1
Show InChI InChI=1S/C22H38N4O/c1-21(2)11-12-22(27-21)9-7-17(8-10-22)20-18(16-25(4)15-13-23-3)24-26-14-5-6-19(20)26/h17,23H,5-16H2,1-4H3/t17-,22?
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502027
PNG
(N1-((3-cyclohexyl- 4,5,6,7-tetrahydro- pyrazolo[1,...)
Show SMILES CNCCN(C)Cc1nn2CCCCc2c1C1CCCCC1
Show InChI InChI=1S/C18H32N4/c1-19-11-13-21(2)14-16-18(15-8-4-3-5-9-15)17-10-6-7-12-22(17)20-16/h15,19H,3-14H2,1-2H3
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502057
PNG
(N1-((3-(4,4-dimethyl- cyclohexyl)-5,6- dihydro-4H-...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1C1CCC(C)(C)CC1
Show InChI InChI=1S/C19H34N4/c1-19(2)9-7-15(8-10-19)18-16(14-22(4)13-11-20-3)21-23-12-5-6-17(18)23/h15,20H,5-14H2,1-4H3
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Board of Regents, The University of Texas System

US Patent


Assay Description
PRMT1,4,6: This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 5...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502031
PNG
(8-(2-((Methyl(2- (methylamino)ethyl)- amino)methyl...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1C1CCC2(CCNC2=O)CC1
Show InChI InChI=1S/C20H33N5O/c1-21-11-13-24(2)14-16-18(17-4-3-12-25(17)23-16)15-5-7-20(8-6-15)9-10-22-19(20)26/h15,21H,3-14H2,1-2H3,(H,22,26)
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502015
PNG
(US11028083, Example 9b)
Show SMILES CNCCN(C)Cc1nn2CCOCc2c1[C@H]1CC[C@@]2(CCN(Cc3ccccc3)C2=O)CC1
Show InChI InChI=1S/C27H39N5O2/c1-28-13-15-30(2)19-23-25(24-20-34-17-16-32(24)29-23)22-8-10-27(11-9-22)12-14-31(26(27)33)18-21-6-4-3-5-7-21/h3-7,22,28H,8-20H2,1-2H3/t22-,27-
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502149
PNG
(US11028083, Example 107b)
Show SMILES CNCCN(C)Cc1nn2CCOCc2c1[C@H]1CC[C@]2(CC1)CCC(C)(C)CO2
Show InChI InChI=1S/C23H40N4O2/c1-22(2)9-10-23(29-17-22)7-5-18(6-8-23)21-19(15-26(4)12-11-24-3)25-27-13-14-28-16-20(21)27/h18,24H,5-17H2,1-4H3/t18-,23-
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502124
PNG
(US11028083, Example 93a)
Show SMILES CNCCN(C)Cc1nn2CCOCc2c1[C@H]1CC[C@]2(CCCOC2)CC1
Show InChI InChI=1S/C21H36N4O2/c1-22-9-10-24(2)14-18-20(19-15-26-13-11-25(19)23-18)17-4-7-21(8-5-17)6-3-12-27-16-21/h17,22H,3-16H2,1-2H3/t17-,21+
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502003
PNG
(US11028083, Example 1b)
Show SMILES CCOC[C@]1(CC)CC[C@@H](CC1)c1c(CN(C)CCNC)nn2CCCc12
Show InChI InChI=1S/C22H40N4O/c1-5-22(17-27-6-2)11-9-18(10-12-22)21-19(16-25(4)15-13-23-3)24-26-14-7-8-20(21)26/h18,23H,5-17H2,1-4H3/t18-,22+
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502005
PNG
(US11028083, Example 3a)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1[C@H]1CC[C@@]2(CC(C)(C)CO2)CC1
Show InChI InChI=1S/C22H38N4O/c1-21(2)15-22(27-16-21)9-7-17(8-10-22)20-18(14-25(4)13-11-23-3)24-26-12-5-6-19(20)26/h17,23H,5-16H2,1-4H3/t17-,22-
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502026
PNG
(N1-((3-(4-(ethoxy- methyl)cyclohexyl)- 5,6-dihydro...)
Show SMILES CCOCC1CCC(CC1)c1c(CN(C)CCNC)nn2CCCc12
Show InChI InChI=1S/C20H36N4O/c1-4-25-15-16-7-9-17(10-8-16)20-18(14-23(3)13-11-21-2)22-24-12-5-6-19(20)24/h16-17,21H,4-15H2,1-3H3
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502102
PNG
(US11028083, Example 79a | US11028083, Example 80a)
Show SMILES CNCCN(C)Cc1nn2CC(F)(F)Cc2c1[C@H]1CC[C@]2(CCCOC2)CC1
Show InChI InChI=1S/C21H34F2N4O/c1-24-9-10-26(2)13-17-19(18-12-21(22,23)14-27(18)25-17)16-4-7-20(8-5-16)6-3-11-28-15-20/h16,24H,3-15H2,1-2H3/t16-,20+
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502016
PNG
(US11028083, Example 10)
Show SMILES CCOCC1(COCC)CCC(CC1)c1c(CN(C)CCNC)nc2CCCn12
Show InChI InChI=1S/C23H42N4O2/c1-5-28-17-23(18-29-6-2)11-9-19(10-12-23)22-20(16-26(4)15-13-24-3)25-21-8-7-14-27(21)22/h19,24H,5-18H2,1-4H3
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502080
PNG
(US11028083, Example 68a)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1[C@H]1CCC2(CCC(=O)N2)CC1
Show InChI InChI=1S/C20H33N5O/c1-21-11-13-24(2)14-16-19(17-4-3-12-25(17)23-16)15-5-8-20(9-6-15)10-7-18(26)22-20/h15,21H,3-14H2,1-2H3,(H,22,26)/t15-,20?
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502106
PNG
(US11028083, Example 81)
Show SMILES CNCCN(C)Cc1nn2CCOCc2c1C1CCC(COC)(COC)CC1
Show InChI InChI=1S/C21H38N4O3/c1-22-9-10-24(2)13-18-20(19-14-28-12-11-25(19)23-18)17-5-7-21(8-6-17,15-26-3)16-27-4/h17,22H,5-16H2,1-4H3
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502010
PNG
(US11028083, Example 6a)
Show SMILES CNCCN(C)Cc1nn2CC(F)(F)Cc2c1[C@H]1CC[C@@](C)(COC)CC1
Show InChI InChI=1S/C20H34F2N4O/c1-19(14-27-4)7-5-15(6-8-19)18-16(12-25(3)10-9-23-2)24-26-13-20(21,22)11-17(18)26/h15,23H,5-14H2,1-4H3/t15-,19+
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502142
PNG
(US11028083, Example 103a)
Show SMILES CC[C@]1(COCC(F)(F)F)CC[C@@H](CC1)c1c(CN(C)CCNC)nn2CC(F)(F)Cc12
Show InChI InChI=1S/C22H35F5N4O/c1-4-20(14-32-15-22(25,26)27)7-5-16(6-8-20)19-17(12-30(3)10-9-28-2)29-31-13-21(23,24)11-18(19)31/h16,28H,4-15H2,1-3H3/t16-,20-
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502032
PNG
(8-(2-((Methyl(2- (methylamino)ethyl)- amino)methyl...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1C1CCC2(CNC(=O)C2)CC1
Show InChI InChI=1S/C20H33N5O/c1-21-9-11-24(2)13-16-19(17-4-3-10-25(17)23-16)15-5-7-20(8-6-15)12-18(26)22-14-20/h15,21H,3-14H2,1-2H3,(H,22,26)
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502024
PNG
(N1-((3-(4-(methoxy- methyl)cyclohexyl)- 5,6-dihydr...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1C1CCC(COC)CC1
Show InChI InChI=1S/C19H34N4O/c1-20-10-12-22(2)13-17-19(18-5-4-11-23(18)21-17)16-8-6-15(7-9-16)14-24-3/h15-16,20H,4-14H2,1-3H3
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502034
PNG
(8-(2-((Methyl(2- (methylamino)ethyl)- amino)methyl...)
Show SMILES CNCCN(C)Cc1nn2CCOCc2c1C1CCC2(CCNC2=O)CC1
Show InChI InChI=1S/C20H33N5O2/c1-21-9-10-24(2)13-16-18(17-14-27-12-11-25(17)23-16)15-3-5-20(6-4-15)7-8-22-19(20)26/h15,21H,3-14H2,1-2H3,(H,22,26)
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502091
PNG
(US11028083, Example 73b)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1[C@H]1CCC2(COC(C)(C)C2)CC1
Show InChI InChI=1S/C22H38N4O/c1-21(2)15-22(16-27-21)9-7-17(8-10-22)20-18(14-25(4)13-11-23-3)24-26-12-5-6-19(20)26/h17,23H,5-16H2,1-4H3/t17-,22?
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502132
PNG
(US11028083, Example 97a)
Show SMILES CNCCN(C)Cc1nn2CCOCc2c1[C@H]1CC[C@]2(CC(C)(C)CO2)CC1
Show InChI InChI=1S/C22H38N4O2/c1-21(2)15-22(28-16-21)7-5-17(6-8-22)20-18(13-25(4)10-9-23-3)24-26-11-12-27-14-19(20)26/h17,23H,5-16H2,1-4H3/t17-,22+
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Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502078
PNG
(US11028083, Example 67a)
Show SMILES CNCCN(C)Cc1nn2CC(F)(F)Cc2c1[C@H]1CCC2(CCN(Cc3ccccc3)C2=O)CC1
Show InChI InChI=1S/C27H37F2N5O/c1-30-13-15-32(2)18-22-24(23-16-27(28,29)19-34(23)31-22)21-8-10-26(11-9-21)12-14-33(25(26)35)17-20-6-4-3-5-7-20/h3-7,21,30H,8-19H2,1-2H3/t21-,26?
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n/an/a 66n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502011
PNG
(US11028083, Example 6b)
Show SMILES CNCCN(C)Cc1nn2CC(F)(F)Cc2c1[C@H]1CC[C@](C)(COC)CC1
Show InChI InChI=1S/C20H34F2N4O/c1-19(14-27-4)7-5-15(6-8-19)18-16(12-25(3)10-9-23-2)24-26-13-20(21,22)11-17(18)26/h15,23H,5-14H2,1-4H3/t15-,19-
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n/an/a 67n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502121
PNG
(US11028083, Example 90)
Show SMILES CCOCC1(COCC)CCC(CC1)c1c(CNCCNC)nn2CC(F)(F)Cc12
Show InChI InChI=1S/C22H38F2N4O2/c1-4-29-15-21(16-30-5-2)8-6-17(7-9-21)20-18(13-26-11-10-25-3)27-28-14-22(23,24)12-19(20)28/h17,25-26H,4-16H2,1-3H3
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n/an/a 68n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502076
PNG
(US11028083, Example 66a)
Show SMILES CCC1(COC)CC[C@@H](CC1)c1c(CN(C)CCNC)nn2CCCc12
Show InChI InChI=1S/C21H38N4O/c1-5-21(16-26-4)10-8-17(9-11-21)20-18(15-24(3)14-12-22-2)23-25-13-6-7-19(20)25/h17,22H,5-16H2,1-4H3/t17-,21?
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n/an/a 68n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502072
PNG
(US11028083, Example 64a)
Show SMILES CCOCC1(C)CCC(CC1)c1c(CN(C)CCNC)nn2CCCc12
Show InChI InChI=1S/C21H38N4O/c1-5-26-16-21(2)10-8-17(9-11-21)20-18(15-24(4)14-12-22-3)23-25-13-6-7-19(20)25/h17,22H,5-16H2,1-4H3
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n/an/a 69n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502086
PNG
(US11028083, Example 71a)
Show SMILES CNCCN(C)Cc1nn2CCOCc2c1[C@H]1CCC2(CCN(CC3CCCCC3)C2=O)CC1
Show InChI InChI=1S/C27H45N5O2/c1-28-13-15-30(2)19-23-25(24-20-34-17-16-32(24)29-23)22-8-10-27(11-9-22)12-14-31(26(27)33)18-21-6-4-3-5-7-21/h21-22,28H,3-20H2,1-2H3/t22-,27?
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n/an/a 69n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502068
PNG
(US11028083, Example 62a)
Show SMILES CCS(=O)(=O)C1CC[C@@H](CC1)c1c(CN(C)CCNC)nn2CCCc12
Show InChI InChI=1S/C19H34N4O2S/c1-4-26(24,25)16-9-7-15(8-10-16)19-17(14-22(3)13-11-20-2)21-23-12-5-6-18(19)23/h15-16,20H,4-14H2,1-3H3/t15-,16?
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n/an/a 70n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502077
PNG
(US11028083, Example 66b)
Show SMILES CCC1(COC)CC[C@@H](CC1)c1c(CN(C)CCNC)nn2CCCc12
Show InChI InChI=1S/C21H38N4O/c1-5-21(16-26-4)10-8-17(9-11-21)20-18(15-24(3)14-12-22-2)23-25-13-6-7-19(20)25/h17,22H,5-16H2,1-4H3/t17-,21?
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n/an/a 70n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502107
PNG
(US11028083, Example 82a | US11028083, Example 82b)
Show SMILES CC[C@]1(COCC(F)(F)F)CC[C@@H](CC1)c1c(CN(C)CCNC)nn2CCOCc12
Show InChI InChI=1S/C22H37F3N4O2/c1-4-21(15-31-16-22(23,24)25)7-5-17(6-8-21)20-18(13-28(3)10-9-26-2)27-29-11-12-30-14-19(20)29/h17,26H,4-16H2,1-3H3/t17-,21-
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n/an/a 70n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502069
PNG
(US11028083, Example 62b)
Show SMILES CCS(=O)(=O)C1CC[C@@H](CC1)c1c(CN(C)CCNC)nn2CCCc12
Show InChI InChI=1S/C19H34N4O2S/c1-4-26(24,25)16-9-7-15(8-10-16)19-17(14-22(3)13-11-20-2)21-23-12-5-6-18(19)23/h15-16,20H,4-14H2,1-3H3/t15-,16?
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n/an/a 70n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502051
PNG
(N1-((3-(4-ethoxy-4- methylcyclohexyl)-5,6- dihydro...)
Show SMILES CCOC1(C)CCC(CC1)c1c(CN(C)CCNC)nn2CCCc12
Show InChI InChI=1S/C20H36N4O/c1-5-25-20(2)10-8-16(9-11-20)19-17(15-23(4)14-12-21-3)22-24-13-6-7-18(19)24/h16,21H,5-15H2,1-4H3
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n/an/a 70n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502036
PNG
(2-Isobutyl-8-(2- ((methyl(2-(methyl- amino)ethyl)a...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1C1CCC2(CCN(CC(C)C)C2=O)CC1
Show InChI InChI=1S/C24H41N5O/c1-18(2)16-28-14-11-24(23(28)30)9-7-19(8-10-24)22-20(17-27(4)15-12-25-3)26-29-13-5-6-21(22)29/h18-19,25H,5-17H2,1-4H3
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n/an/a 71n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502119
PNG
(US11028083, Example 89a)
Show SMILES CNCCN(C)Cc1nn2CC(F)(F)Cc2c1[C@H]1CC[C@]2(CCCC(C)(C)O2)CC1
Show InChI InChI=1S/C23H38F2N4O/c1-21(2)8-5-9-22(30-21)10-6-17(7-11-22)20-18(15-28(4)13-12-26-3)27-29-16-23(24,25)14-19(20)29/h17,26H,5-16H2,1-4H3/t17-,22+
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n/an/a 71n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502134
PNG
(US11028083, Example 98a)
Show SMILES CNCCN(C)Cc1nn2CCOCc2c1[C@H]1CC[C@]2(CCCCO2)CC1
Show InChI InChI=1S/C21H36N4O2/c1-22-10-11-24(2)15-18-20(19-16-26-14-12-25(19)23-18)17-5-8-21(9-6-17)7-3-4-13-27-21/h17,22H,3-16H2,1-2H3/t17-,21+
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n/an/a 71n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502111
PNG
(US11028083, Example 84)
Show SMILES CCOCC1(COCC)CCC(CC1)c1c(CN(C)CCNC)nn2CC3(CC3)Cc12
Show InChI InChI=1S/C25H44N4O2/c1-5-30-18-25(19-31-6-2)9-7-20(8-10-25)23-21(16-28(4)14-13-26-3)27-29-17-24(11-12-24)15-22(23)29/h20,26H,5-19H2,1-4H3
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n/an/a 71n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502123
PNG
(US11028083, Example 92)
Show SMILES CCOCC1(COCC)CCC(CC1)c1c(CNCCN)nn2CC(F)(F)Cc12
Show InChI InChI=1S/C21H36F2N4O2/c1-3-28-14-20(15-29-4-2)7-5-16(6-8-20)19-17(12-25-10-9-24)26-27-13-21(22,23)11-18(19)27/h16,25H,3-15,24H2,1-2H3
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n/an/a 73n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM502055
PNG
(N1,N2-dimethyl-N1-((3- (spiro[4.5]decan-8-yl)- 5,6...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1C1CCC2(CCCC2)CC1
Show InChI InChI=1S/C21H36N4/c1-22-13-15-24(2)16-18-20(19-6-5-14-25(19)23-18)17-7-11-21(12-8-17)9-3-4-10-21/h17,22H,3-16H2,1-2H3
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n/an/a 74n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
PRMT1,4,6: This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 5...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502090
PNG
(US11028083, Example 73a)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1[C@H]1CCC2(COC(C)(C)C2)CC1
Show InChI InChI=1S/C22H38N4O/c1-21(2)15-22(16-27-21)9-7-17(8-10-22)20-18(14-25(4)13-11-23-3)24-26-12-5-6-19(20)26/h17,23H,5-16H2,1-4H3/t17-,22?
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n/an/a 74n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502092
PNG
(US11028083, Example 74a)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1[C@H]1CCC2(CCCOC2)CC1
Show InChI InChI=1S/C21H36N4O/c1-22-11-13-24(2)15-18-20(19-5-3-12-25(19)23-18)17-6-9-21(10-7-17)8-4-14-26-16-21/h17,22H,3-16H2,1-2H3/t17-,21?
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n/an/a 74n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502043
PNG
(2-Ethyl-8-(2-((methyl- (2-(methylamino)- ethyl)ami...)
Show SMILES CCN1CCC2(CCC(CC2)c2c(CN(C)CCNC)nn3CCCc23)C1=O
Show InChI InChI=1S/C22H37N5O/c1-4-26-14-11-22(21(26)28)9-7-17(8-10-22)20-18(16-25(3)15-12-23-2)24-27-13-5-6-19(20)27/h17,23H,4-16H2,1-3H3
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n/an/a 75n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502100
PNG
(US11028083, Example 78a)
Show SMILES CNCCN(C)Cc1nn2CC(F)(F)Cc2c1[C@H]1CC[C@]2(CC(C)(C)CO2)CC1
Show InChI InChI=1S/C22H36F2N4O/c1-20(2)13-21(29-15-20)7-5-16(6-8-21)19-17(12-27(4)10-9-25-3)26-28-14-22(23,24)11-18(19)28/h16,25H,5-15H2,1-4H3/t16-,21+
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n/an/a 75n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502144
PNG
(US11028083, Example 104a)
Show SMILES CCOC[C@@]1(CCC(F)(F)F)CC[C@@H](CC1)c1c(CN(C)CCNC)nn2CCOCc12
Show InChI InChI=1S/C23H39F3N4O2/c1-4-31-17-22(9-10-23(24,25)26)7-5-18(6-8-22)21-19(15-29(3)12-11-27-2)28-30-13-14-32-16-20(21)30/h18,27H,4-17H2,1-3H3/t18-,22-
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n/an/a 76n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502023
PNG
(N1-((3-(1-oxaspiro- [4.5]decan-8-yl)-5,6- dihydro-...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1C1CCC2(CCCO2)CC1
Show InChI InChI=1S/C20H34N4O/c1-21-11-13-23(2)15-17-19(18-5-3-12-24(18)22-17)16-6-9-20(10-7-16)8-4-14-25-20/h16,21H,3-15H2,1-2H3
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n/an/a 76n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502110
PNG
(US11028083, Example 83b)
Show SMILES CCOC[C@]1(CCC(F)(F)F)CC[C@@H](CC1)c1c(CN(C)CCNC)nn2CC(F)(F)Cc12
Show InChI InChI=1S/C23H37F5N4O/c1-4-33-16-21(9-10-23(26,27)28)7-5-17(6-8-21)20-18(14-31(3)12-11-29-2)30-32-15-22(24,25)13-19(20)32/h17,29H,4-16H2,1-3H3/t17-,21+
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n/an/a 78n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502096
PNG
(US11028083, Example 76a)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1[C@H]1CCC2(CCCCO2)CC1
Show InChI InChI=1S/C21H36N4O/c1-22-12-14-24(2)16-18-20(19-6-5-13-25(19)23-18)17-7-10-21(11-8-17)9-3-4-15-26-21/h17,22H,3-16H2,1-2H3/t17-,21?
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n/an/a 79n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM502004
PNG
(US11028083, Example 2)
Show SMILES CCOCC1(COCC)CCC(CC1)c1c(CN(C)CCNC)nn2CCCc12
Show InChI InChI=1S/C23H42N4O2/c1-5-28-17-23(18-29-6-2)11-9-19(10-12-23)22-20(16-26(4)15-13-24-3)25-27-14-7-8-21(22)27/h19,24H,5-18H2,1-4H3
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n/an/a 79n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
PRMT1,4,6: This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 5...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM502057
PNG
(N1-((3-(4,4-dimethyl- cyclohexyl)-5,6- dihydro-4H-...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1C1CCC(C)(C)CC1
Show InChI InChI=1S/C19H34N4/c1-19(2)9-7-15(8-10-19)18-16(14-22(4)13-11-20-3)21-23-12-5-6-17(18)23/h15,20H,5-14H2,1-4H3
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n/an/a 79n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
PRMT1,4,6: This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 5...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502045
PNG
(2-Isopropyl-8-(2- ((methyl(2-(methyl- amino)ethyl)...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1C1CCC2(CCN(C(C)C)C2=O)CC1
Show InChI InChI=1S/C23H39N5O/c1-17(2)27-14-11-23(22(27)29)9-7-18(8-10-23)21-19(16-26(4)15-12-24-3)25-28-13-5-6-20(21)28/h17-18,24H,5-16H2,1-4H3
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n/an/a 80n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502109
PNG
(US11028083, Example 83a)
Show SMILES CCOC[C@@]1(CCC(F)(F)F)CC[C@@H](CC1)c1c(CN(C)CCNC)nn2CC(F)(F)Cc12
Show InChI InChI=1S/C23H37F5N4O/c1-4-33-16-21(9-10-23(26,27)28)7-5-17(6-8-21)20-18(14-31(3)12-11-29-2)30-32-15-22(24,25)13-19(20)32/h17,29H,4-16H2,1-3H3/t17-,21-
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n/an/a 83n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502027
PNG
(N1-((3-cyclohexyl- 4,5,6,7-tetrahydro- pyrazolo[1,...)
Show SMILES CNCCN(C)Cc1nn2CCCCc2c1C1CCCCC1
Show InChI InChI=1S/C18H32N4/c1-19-11-13-21(2)14-16-18(15-8-4-3-5-9-15)17-10-6-7-12-22(17)20-16/h15,19H,3-14H2,1-2H3
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n/an/a 84n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
PRMT1,4,6: This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 5...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502040
PNG
(N1-((3-(4,4-bis- (methoxymethyl)- cyclohexyl)-5,6-...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1C1CCC(COC)(COC)CC1
Show InChI InChI=1S/C21H38N4O2/c1-22-11-13-24(2)14-18-20(19-6-5-12-25(19)23-18)17-7-9-21(10-8-17,15-26-3)16-27-4/h17,22H,5-16H2,1-4H3
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n/an/a 84n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502035
PNG
(2-Isobutyl-8-(2- ((methyl(2-(methyl- amino)ethyl)a...)
Show SMILES CNCCN(C)Cc1nn2CCOCc2c1C1CCC2(CCN(CC(C)C)C2=O)CC1
Show InChI InChI=1S/C24H41N5O2/c1-18(2)15-28-11-9-24(23(28)30)7-5-19(6-8-24)22-20(16-27(4)12-10-25-3)26-29-13-14-31-17-21(22)29/h18-19,25H,5-17H2,1-4H3
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n/an/a 87n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502053
PNG
(N1-((3-(2-oxaspiro- [3.5]nonan-7-yl)-5,6- dihydro-...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1C1CCC2(COC2)CC1
Show InChI InChI=1S/C19H32N4O/c1-20-9-11-22(2)12-16-18(17-4-3-10-23(17)21-16)15-5-7-19(8-6-15)13-24-14-19/h15,20H,3-14H2,1-2H3
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n/an/a 87n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502004
PNG
(US11028083, Example 2)
Show SMILES CCOCC1(COCC)CCC(CC1)c1c(CN(C)CCNC)nn2CCCc12
Show InChI InChI=1S/C23H42N4O2/c1-5-28-17-23(18-29-6-2)11-9-19(10-12-23)22-20(16-26(4)15-13-24-3)25-27-14-7-8-21(22)27/h19,24H,5-18H2,1-4H3
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n/an/a 88n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502052
PNG
(N1,N2-dimethyl-N1-((3- (4-methyl-4- propoxycyclohe...)
Show SMILES CCCOC1(C)CCC(CC1)c1c(CN(C)CCNC)nn2CCCc12
Show InChI InChI=1S/C21H38N4O/c1-5-15-26-21(2)10-8-17(9-11-21)20-18(16-24(4)14-12-22-3)23-25-13-6-7-19(20)25/h17,22H,5-16H2,1-4H3
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n/an/a 89n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502145
PNG
(US11028083, Example 104b)
Show SMILES CCOC[C@]1(CCC(F)(F)F)CC[C@@H](CC1)c1c(CN(C)CCNC)nn2CCOCc12
Show InChI InChI=1S/C23H39F3N4O2/c1-4-31-17-22(9-10-23(24,25)26)7-5-18(6-8-22)21-19(15-29(3)12-11-27-2)28-30-13-14-32-16-20(21)30/h18,27H,4-17H2,1-3H3/t18-,22+
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n/an/a 91n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502002
PNG
(US11028083, Example 1a)
Show SMILES CCOC[C@@]1(CC)CC[C@@H](CC1)c1c(CN(C)CCNC)nn2CCCc12
Show InChI InChI=1S/C22H40N4O/c1-5-22(17-27-6-2)11-9-18(10-12-22)21-19(16-25(4)15-13-23-3)24-26-14-7-8-20(21)26/h18,23H,5-17H2,1-4H3/t18-,22-
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n/an/a 93n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502017
PNG
(N1-((3-cyclohexyl-5,6- dihydro-4H-pyrrolo- [1,2-b]...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1C1CCCCC1
Show InChI InChI=1S/C17H30N4/c1-18-10-12-20(2)13-15-17(14-7-4-3-5-8-14)16-9-6-11-21(16)19-15/h14,18H,3-13H2,1-2H3
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n/an/a 93n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
PRMT1,4,6: This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 5...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502062
PNG
(N1-((3-(4-ethoxy-4- (ethoxymethyl)cyclo- hexyl)-5,...)
Show SMILES CCOCC1(CCC(CC1)c1c(CN(C)CCNC)nn2CCCc12)OCC
Show InChI InChI=1S/C22H40N4O2/c1-5-27-17-22(28-6-2)11-9-18(10-12-22)21-19(16-25(4)15-13-23-3)24-26-14-7-8-20(21)26/h18,23H,5-17H2,1-4H3
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n/an/a 95n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502039
PNG
(2-Methyl-8-(2- ((methyl(2-(methyl- amino)ethyl)ami...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1C1CCC2(CCN(C)C2=O)CC1
Show InChI InChI=1S/C21H35N5O/c1-22-11-14-24(2)15-17-19(18-5-4-12-26(18)23-17)16-6-8-21(9-7-16)10-13-25(3)20(21)27/h16,22H,4-15H2,1-3H3
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n/an/a 95n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502047
PNG
(2-(2-Methoxyethyl)-8- (2-((methyl(2-(methyl- amino...)
Show SMILES CNCCN(C)Cc1nn2CCOCc2c1C1CCC2(CCN(CCOC)C2=O)CC1
Show InChI InChI=1S/C23H39N5O3/c1-24-9-11-26(2)16-19-21(20-17-31-15-13-28(20)25-19)18-4-6-23(7-5-18)8-10-27(22(23)29)12-14-30-3/h18,24H,4-17H2,1-3H3
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n/an/a 98n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502117
PNG
(US11028083, Example 88a)
Show SMILES CNCCN(C)Cc1nn2CC(F)(F)Cc2c1[C@H]1CC[C@@]2(CC1)CCC(C)(C)CO2
Show InChI InChI=1S/C23H38F2N4O/c1-21(2)9-10-22(30-16-21)7-5-17(6-8-22)20-18(14-28(4)12-11-26-3)27-29-15-23(24,25)13-19(20)29/h17,26H,5-16H2,1-4H3/t17-,22+
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n/an/a 98n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502112
PNG
(US11028083, Example 85)
Show SMILES CCOCC1(COCC)CCC(CC1)c1c(CN(C)CCNC)nn2CCC(F)(F)Cc12
Show InChI InChI=1S/C24H42F2N4O2/c1-5-31-17-23(18-32-6-2)9-7-19(8-10-23)22-20(16-29(4)14-12-27-3)28-30-13-11-24(25,26)15-21(22)30/h19,27H,5-18H2,1-4H3
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n/an/a 99n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502050
PNG
(N1-((3-(4-methoxy-4- methylcyclohexyl)-5,6- dihydr...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1C1CCC(C)(CC1)OC
Show InChI InChI=1S/C19H34N4O/c1-19(24-4)9-7-15(8-10-19)18-16(14-22(3)13-11-20-2)21-23-12-5-6-17(18)23/h15,20H,5-14H2,1-4H3
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n/an/a 99n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM502017
PNG
(N1-((3-cyclohexyl-5,6- dihydro-4H-pyrrolo- [1,2-b]...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1C1CCCCC1
Show InChI InChI=1S/C17H30N4/c1-18-10-12-20(2)13-15-17(14-7-4-3-5-8-14)16-9-6-11-21(16)19-15/h14,18H,3-13H2,1-2H3
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n/an/a 99n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
PRMT1,4,6: This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 5...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502083
PNG
(US11028083, Example 69b)
Show SMILES CNCCN(C)Cc1nn2CCOCc2c1[C@H]1CCC2(CC(C)(C)CO2)CC1
Show InChI InChI=1S/C22H38N4O2/c1-21(2)15-22(28-16-21)7-5-17(6-8-22)20-18(13-25(4)10-9-23-3)24-26-11-12-27-14-19(20)26/h17,23H,5-16H2,1-4H3/t17-,22?
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n/an/a 101n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502146
PNG
(N1-((3-(4,4-bis(ethoxy- methyl)cyclohexyl)-5,5- di...)
Show SMILES CCOCC1(COCC)CCC(CC1)c1c(CN(C)CCNC)nn2CCC(C)(C)Cc12
Show InChI InChI=1S/C26H48N4O2/c1-7-31-19-26(20-32-8-2)11-9-21(10-12-26)24-22(18-29(6)16-14-27-5)28-30-15-13-25(3,4)17-23(24)30/h21,27H,7-20H2,1-6H3
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n/an/a 105n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502055
PNG
(N1,N2-dimethyl-N1-((3- (spiro[4.5]decan-8-yl)- 5,6...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1C1CCC2(CCCC2)CC1
Show InChI InChI=1S/C21H36N4/c1-22-13-15-24(2)16-18-20(19-6-5-14-25(19)23-18)17-7-11-21(12-8-17)9-3-4-10-21/h17,22H,3-16H2,1-2H3
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n/an/a 106n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
PRMT1,4,6: This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 5...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502073
PNG
(US11028083, Example 64b)
Show SMILES CCOCC1(C)CC[C@@H](CC1)c1c(CN(C)CCNC)nn2CCCc12
Show InChI InChI=1S/C21H38N4O/c1-5-26-16-21(2)10-8-17(9-11-21)20-18(15-24(4)14-12-22-3)23-25-13-6-7-19(20)25/h17,22H,5-16H2,1-4H3/t17-,21?
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n/an/a 111n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502048
PNG
(2-Isopropyl-8-(2- ((methyl(2-(methyl- amino)ethyl)...)
Show SMILES CNCCN(C)Cc1nn2CCOCc2c1C1CCC2(CCN(C(C)C)C2=O)CC1
Show InChI InChI=1S/C23H39N5O2/c1-17(2)27-11-9-23(22(27)29)7-5-18(6-8-23)21-19(15-26(4)12-10-24-3)25-28-13-14-30-16-20(21)28/h17-18,24H,5-16H2,1-4H3
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n/an/a 114n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM502055
PNG
(N1,N2-dimethyl-N1-((3- (spiro[4.5]decan-8-yl)- 5,6...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1C1CCC2(CCCC2)CC1
Show InChI InChI=1S/C21H36N4/c1-22-13-15-24(2)16-18-20(19-6-5-14-25(19)23-18)17-7-11-21(12-8-17)9-3-4-10-21/h17,22H,3-16H2,1-2H3
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n/an/a 114n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
PRMT1,4,6: This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 5...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502037
PNG
(2-Methyl-8-(2- ((methyl(2-(methyl- amino)ethyl)ami...)
Show SMILES CNCCN(C)Cc1nn2CCOCc2c1C1CCC2(CCN(C)C2=O)CC1
Show InChI InChI=1S/C21H35N5O2/c1-22-9-11-24(2)14-17-19(18-15-28-13-12-26(18)23-17)16-4-6-21(7-5-16)8-10-25(3)20(21)27/h16,22H,4-15H2,1-3H3
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n/an/a 117n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502029
PNG
(N1-((3-(4,4-bis(ethoxy- methyl)cyclohexyl)- 6,7-di...)
Show SMILES CCOCC1(COCC)CCC(CC1)c1c(CN(C)CCNC)nn2CCOCc12
Show InChI InChI=1S/C23H42N4O3/c1-5-28-17-23(18-29-6-2)9-7-19(8-10-23)22-20(15-26(4)12-11-24-3)25-27-13-14-30-16-21(22)27/h19,24H,5-18H2,1-4H3
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n/an/a 125n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502006
PNG
(US11028083, Example 3b)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1[C@H]1CC[C@]2(CC(C)(C)CO2)CC1
Show InChI InChI=1S/C22H38N4O/c1-21(2)15-22(27-16-21)9-7-17(8-10-22)20-18(14-25(4)13-11-23-3)24-26-12-5-6-19(20)26/h17,23H,5-16H2,1-4H3/t17-,22+
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n/an/a 125n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502067
PNG
(3-(4,4-bis(Methoxy- methyl)cyclohexyl)-2- ((methyl...)
Show SMILES CNCCN(C)Cc1nn2CC(O)Cc2c1C1CCC(COC)(COC)CC1
Show InChI InChI=1S/C21H38N4O3/c1-22-9-10-24(2)13-18-20(19-11-17(26)12-25(19)23-18)16-5-7-21(8-6-16,14-27-3)15-28-4/h16-17,22,26H,5-15H2,1-4H3
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n/an/a 126n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502098
PNG
(US11028083, Example 77a)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1[C@H]1CCC(C)(CC1)C(=O)N(C)C
Show InChI InChI=1S/C21H37N5O/c1-21(20(27)24(3)4)10-8-16(9-11-21)19-17(15-25(5)14-12-22-2)23-26-13-6-7-18(19)26/h16,22H,6-15H2,1-5H3/t16-,21?
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n/an/a 127n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502021
PNG
(N1-((3-(1-(ethyl- sulfonyl)-1,2,3,6-tetra- hydropy...)
Show SMILES CCS(=O)(=O)N1CCC(=CC1)c1c(CN(C)CCNC)nn2CCCc12
Show InChI InChI=1S/C18H31N5O2S/c1-4-26(24,25)22-11-7-15(8-12-22)18-16(14-21(3)13-9-19-2)20-23-10-5-6-17(18)23/h7,19H,4-6,8-14H2,1-3H3
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n/an/a 128n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502064
PNG
(N1-((3-(6,6-bis(ethoxy- methyl)bicyclo[3.1.0]- hex...)
Show SMILES CCOCC1(COCC)C2CC(CC12)c1c(CN(C)CCNC)nn2CCCc12
Show InChI InChI=1S/C23H40N4O2/c1-5-28-15-23(16-29-6-2)18-12-17(13-19(18)23)22-20(14-26(4)11-9-24-3)25-27-10-7-8-21(22)27/h17-19,24H,5-16H2,1-4H3
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n/an/a 128n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502141
PNG
(N1-((3-(4,4-bis((2,2,2- trifluoroethoxy)methyl)- c...)
Show SMILES CNCCN(C)Cc1nn2CC(F)(F)Cc2c1C1CCC(COCC(F)(F)F)(COCC(F)(F)F)CC1
Show InChI InChI=1S/C23H34F8N4O2/c1-32-7-8-34(2)10-17-19(18-9-21(24,25)11-35(18)33-17)16-3-5-20(6-4-16,12-36-14-22(26,27)28)13-37-15-23(29,30)31/h16,32H,3-15H2,1-2H3
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n/an/a 128n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502061
PNG
(N-ethyl-1-methyl-4-(2- ((methyl(2-(methyl- amino)e...)
Show SMILES CCNC(=O)C1(C)CCC(CC1)c1c(CN(C)CCNC)nn2CCCc12
Show InChI InChI=1S/C21H37N5O/c1-5-23-20(27)21(2)10-8-16(9-11-21)19-17(15-25(4)14-12-22-3)24-26-13-6-7-18(19)26/h16,22H,5-15H2,1-4H3,(H,23,27)
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n/an/a 134n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM502027
PNG
(N1-((3-cyclohexyl- 4,5,6,7-tetrahydro- pyrazolo[1,...)
Show SMILES CNCCN(C)Cc1nn2CCCCc2c1C1CCCCC1
Show InChI InChI=1S/C18H32N4/c1-19-11-13-21(2)14-16-18(15-8-4-3-5-9-15)17-10-6-7-12-22(17)20-16/h15,19H,3-14H2,1-2H3
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n/an/a 141n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
PRMT1,4,6: This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 5...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502094
PNG
(US11028083, Example 75a)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1[C@H]1CCC2(CCC(C)(C)O2)CC1
Show InChI InChI=1S/C22H38N4O/c1-21(2)11-12-22(27-21)9-7-17(8-10-22)20-18(16-25(4)15-13-23-3)24-26-14-5-6-19(20)26/h17,23H,5-16H2,1-4H3/t17-,22?
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n/an/a 147n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502066
PNG
(1-(3-(4,4-bis(Ethoxy- methyl)cyclohexyl)-2- ((meth...)
Show SMILES CCOCC1(COCC)CCC(CC1)c1c(CN(C)CCNC)nn2CCN(Cc12)C(=O)CC
Show InChI InChI=1S/C26H47N5O3/c1-6-24(32)30-15-16-31-23(18-30)25(22(28-31)17-29(5)14-13-27-4)21-9-11-26(12-10-21,19-33-7-2)20-34-8-3/h21,27H,6-20H2,1-5H3
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n/an/a 148n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502018
PNG
(Benzyl 4-(2-((methyl- (2-(methylamino)- ethyl)amin...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1C1=CCN(CC1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C24H33N5O2/c1-25-12-16-27(2)17-21-23(22-9-6-13-29(22)26-21)20-10-14-28(15-11-20)24(30)31-18-19-7-4-3-5-8-19/h3-5,7-8,10,25H,6,9,11-18H2,1-2H3
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n/an/a 151n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502042
PNG
(N1-((3-(4,4-bis(ethoxy- methyl)cyclohexyl)- 5,6-di...)
Show SMILES CCOCC1(COCC)CCC(CC1)c1c(CN(C)CCNC)nc2COCCn12
Show InChI InChI=1S/C23H42N4O3/c1-5-28-17-23(18-29-6-2)9-7-19(8-10-23)22-20(15-26(4)12-11-24-3)25-21-16-30-14-13-27(21)22/h19,24H,5-18H2,1-4H3
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n/an/a 156n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502025
PNG
(Ethyl 1-methyl-4-(2- ((methyl(2-(methyl- amino)eth...)
Show SMILES CCOC(=O)C1(C)CCC(=CC1)c1c(CN(C)CCNC)nn2CCCc12
Show InChI InChI=1S/C21H34N4O2/c1-5-27-20(26)21(2)10-8-16(9-11-21)19-17(15-24(4)14-12-22-3)23-25-13-6-7-18(19)25/h8,22H,5-7,9-15H2,1-4H3
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n/an/a 156n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502089
PNG
(US11028083, Example 72b)
Show SMILES CNCCN(C)Cc1nn2CCOCc2c1[C@H]1CCC2(CCN(Cc3ccn(C)n3)C2=O)CC1
Show InChI InChI=1S/C25H39N7O2/c1-26-10-13-29(2)17-21-23(22-18-34-15-14-32(22)28-21)19-4-7-25(8-5-19)9-12-31(24(25)33)16-20-6-11-30(3)27-20/h6,11,19,26H,4-5,7-10,12-18H2,1-3H3/t19-,25?
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n/an/a 163n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502007
PNG
(US11028083, Example 4)
Show SMILES CCOCC1(COCC)CCC(CC1)c1c(CN(C)CCNC)nn2CC(F)(F)Cc12
Show InChI InChI=1S/C23H40F2N4O2/c1-5-30-16-22(17-31-6-2)9-7-18(8-10-22)21-19(14-28(4)12-11-26-3)27-29-15-23(24,25)13-20(21)29/h18,26H,5-17H2,1-4H3
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n/an/a 163n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502046
PNG
(2-(2-Methoxyethyl)-8- (2-((methyl(2-(methyl- amino...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1C1CCC2(CCN(CCOC)C2=O)CC1
Show InChI InChI=1S/C23H39N5O2/c1-24-11-14-26(2)17-19-21(20-5-4-12-28(20)25-19)18-6-8-23(9-7-18)10-13-27(22(23)29)15-16-30-3/h18,24H,4-17H2,1-3H3
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n/an/a 166n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502044
PNG
(2-Ethyl-8-(2-((methyl- (2-(methylamino)- ethyl)ami...)
Show SMILES CCN1CCC2(CCC(CC2)c2c(CN(C)CCNC)nn3CCOCc23)C1=O
Show InChI InChI=1S/C22H37N5O2/c1-4-26-11-9-22(21(26)28)7-5-17(6-8-22)20-18(15-25(3)12-10-23-2)24-27-13-14-29-16-19(20)27/h17,23H,4-16H2,1-3H3
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n/an/a 168n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502041
PNG
(N1-((3-(4,4-bis- (methoxymethyl)- cyclohexyl)-4,5,...)
Show SMILES CNCCN(C)Cc1nn2CCCCc2c1C1CCC(COC)(COC)CC1
Show InChI InChI=1S/C22H40N4O2/c1-23-12-14-25(2)15-19-21(20-7-5-6-13-26(20)24-19)18-8-10-22(11-9-18,16-27-3)17-28-4/h18,23H,5-17H2,1-4H3
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n/an/a 172n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502020
PNG
(1-(4-(2-((Methyl(2- (methylamino)ethyl)- amino)met...)
Show SMILES CCC(=O)N1CCC(=CC1)c1c(CN(C)CCNC)nn2CCCc12
Show InChI InChI=1S/C19H31N5O/c1-4-18(25)23-11-7-15(8-12-23)19-16(14-22(3)13-9-20-2)21-24-10-5-6-17(19)24/h7,20H,4-6,8-14H2,1-3H3
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n/an/a 173n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502147
PNG
(N1-((3-(4,4-bis(ethoxy- methyl)cyclohexyl)-5- (tri...)
Show SMILES CCOCC1(COCC)CCC(CC1)c1c(CN(C)CCNC)nn2CCC(Cc12)C(F)(F)F
Show InChI InChI=1S/C25H43F3N4O2/c1-5-33-17-24(18-34-6-2)10-7-19(8-11-24)23-21(16-31(4)14-12-29-3)30-32-13-9-20(15-22(23)32)25(26,27)28/h19-20,29H,5-18H2,1-4H3
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n/an/a 173n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502082
PNG
(US11028083, Example 69a)
Show SMILES CNCCN(C)Cc1nn2CCOCc2c1[C@H]1CCC2(CC(C)(C)CO2)CC1
Show InChI InChI=1S/C22H38N4O2/c1-21(2)15-22(28-16-21)7-5-17(6-8-22)20-18(13-25(4)10-9-23-3)24-26-11-12-27-14-19(20)26/h17,23H,5-16H2,1-4H3/t17-,22?
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n/an/a 174n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502054
PNG
(1-Methyl-8-(2- ((methyl(2-(methyl- amino)ethyl)ami...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1C1CCC2(CCC(=O)N2C)CC1
Show InChI InChI=1S/C21H35N5O/c1-22-12-14-24(2)15-17-20(18-5-4-13-26(18)23-17)16-6-9-21(10-7-16)11-8-19(27)25(21)3/h16,22H,4-15H2,1-3H3
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n/an/a 176n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502030
PNG
(N1-((3-(4,4-bis(ethoxy- methyl)cyclohexyl)- 4,5,6,...)
Show SMILES CCOCC1(COCC)CCC(CC1)c1c(CN(C)CCNC)nn2CCCCc12
Show InChI InChI=1S/C24H44N4O2/c1-5-29-18-24(19-30-6-2)12-10-20(11-13-24)23-21(17-27(4)16-14-25-3)26-28-15-8-7-9-22(23)28/h20,25H,5-19H2,1-4H3
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n/an/a 203n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502071
PNG
(US11028083, Example 63b)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1[C@H]1CCC2(CCN(C)C2=O)CC1
Show InChI InChI=1S/C21H35N5O/c1-22-11-14-24(2)15-17-19(18-5-4-12-26(18)23-17)16-6-8-21(9-7-16)10-13-25(3)20(21)27/h16,22H,4-15H2,1-3H3/t16-,21?
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n/an/a 217n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502088
PNG
(US11028083, Example 72a)
Show SMILES CNCCN(C)Cc1nn2CCOCc2c1[C@H]1CCC2(CCN(Cc3ccn(C)n3)C2=O)CC1
Show InChI InChI=1S/C25H39N7O2/c1-26-10-13-29(2)17-21-23(22-18-34-15-14-32(22)28-21)19-4-7-25(8-5-19)9-12-31(24(25)33)16-20-6-11-30(3)27-20/h6,11,19,26H,4-5,7-10,12-18H2,1-3H3/t19-,25?
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n/an/a 243n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502058
PNG
((4-(2-((Methyl(2- (methylamino)ethyl)- amino)methy...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1C1=CCN(CC1)C(=O)C1(C)CC1
Show InChI InChI=1S/C21H33N5O/c1-21(8-9-21)20(27)25-12-6-16(7-13-25)19-17(15-24(3)14-10-22-2)23-26-11-4-5-18(19)26/h6,22H,4-5,7-15H2,1-3H3
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n/an/a 256n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 6


(Homo sapiens (Human))
BDBM502004
PNG
(US11028083, Example 2)
Show SMILES CCOCC1(COCC)CCC(CC1)c1c(CN(C)CCNC)nn2CCCc12
Show InChI InChI=1S/C23H42N4O2/c1-5-28-17-23(18-29-6-2)11-9-19(10-12-23)22-20(16-26(4)15-13-24-3)25-27-14-7-8-21(22)27/h19,24H,5-18H2,1-4H3
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n/an/a 314n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
PRMT1,4,6: This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 5...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502059
PNG
(N-(3-(2-((methyl(2- (methylamino)ethyl)- amino)met...)
Show SMILES CCS(=O)(=O)NC1CCC(C1)c1c(CN(C)CCNC)nn2CCCc12
Show InChI InChI=1S/C18H33N5O2S/c1-4-26(24,25)21-15-8-7-14(12-15)18-16(13-22(3)11-9-19-2)20-23-10-5-6-17(18)23/h14-15,19,21H,4-13H2,1-3H3
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n/an/a 317n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502004
PNG
(US11028083, Example 2)
Show SMILES CCOCC1(COCC)CCC(CC1)c1c(CN(C)CCNC)nn2CCCc12
Show InChI InChI=1S/C23H42N4O2/c1-5-28-17-23(18-29-6-2)11-9-19(10-12-23)22-20(16-26(4)15-13-24-3)25-27-14-7-8-21(22)27/h19,24H,5-18H2,1-4H3
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n/an/a 331n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
PRMT1,4,6: This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 5...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM502057
PNG
(N1-((3-(4,4-dimethyl- cyclohexyl)-5,6- dihydro-4H-...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1C1CCC(C)(C)CC1
Show InChI InChI=1S/C19H34N4/c1-19(2)9-7-15(8-10-19)18-16(14-22(4)13-11-20-3)21-23-12-5-6-17(18)23/h15,20H,5-14H2,1-4H3
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n/an/a 337n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
PRMT1,4,6: This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 5...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502065
PNG
((3-(4,4-bis(Ethoxy- methyl)cyclohexyl)-2- ((methyl...)
Show SMILES CCOCC1(COCC)CCC(CC1)c1c(CN(C)CCNC)nn2C(CO)CCc12
Show InChI InChI=1S/C24H44N4O3/c1-5-30-17-24(18-31-6-2)11-9-19(10-12-24)23-21(15-27(4)14-13-25-3)26-28-20(16-29)7-8-22(23)28/h19-20,25,29H,5-18H2,1-4H3
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n/an/a 362n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502060
PNG
(N-(3-(2-((methyl(2- (methylamino)ethyl)- amino)met...)
Show SMILES CCC(=O)NC1CCC(C1)c1c(CN(C)CCNC)nn2CCCc12
Show InChI InChI=1S/C19H33N5O/c1-4-18(25)21-15-8-7-14(12-15)19-16(13-23(3)11-9-20-2)22-24-10-5-6-17(19)24/h14-15,20H,4-13H2,1-3H3,(H,21,25)
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n/an/a 398n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502081
PNG
(US11028083, Example 68b)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1[C@H]1CCC2(CCC(=O)N2)CC1
Show InChI InChI=1S/C20H33N5O/c1-21-11-13-24(2)14-16-19(17-4-3-12-25(17)23-16)15-5-8-20(9-6-15)10-7-18(26)22-20/h15,21H,3-14H2,1-2H3,(H,22,26)/t15-,20?
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n/an/a 434n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502056
PNG
(N1-((3-cyclopentyl-5,6- dihydro-4H-pyrrolo- [1,2-b...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1C1CCCC1
Show InChI InChI=1S/C16H28N4/c1-17-9-11-19(2)12-14-16(13-6-3-4-7-13)15-8-5-10-20(15)18-14/h13,17H,3-12H2,1-2H3
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n/an/a 444n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502099
PNG
(US11028083, Example 77b)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1[C@H]1CCC(C)(CC1)C(=O)N(C)C
Show InChI InChI=1S/C21H37N5O/c1-21(20(27)24(3)4)10-8-16(9-11-21)19-17(15-25(5)14-12-22-2)23-26-13-6-7-18(19)26/h16,22H,6-15H2,1-5H3/t16-,21?
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n/an/a 457n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502087
PNG
(US11028083, Example 71b)
Show SMILES CNCCN(C)Cc1nn2CCOCc2c1[C@H]1CCC2(CCN(CC3CCCCC3)C2=O)CC1
Show InChI InChI=1S/C27H45N5O2/c1-28-13-15-30(2)19-23-25(24-20-34-17-16-32(24)29-23)22-8-10-27(11-9-22)12-14-31(26(27)33)18-21-6-4-3-5-7-21/h21-22,28H,3-20H2,1-2H3/t22-,27?
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n/an/a 537n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502063
PNG
(3-(4,4-bis(Ethoxy- methyl)cyclohexyl)-2- ((methyl(...)
Show SMILES CCOCC1(COCC)CCC(CC1)c1c(CN(C)CCNC)nn2CC(O)CCc12
Show InChI InChI=1S/C24H44N4O3/c1-5-30-17-24(18-31-6-2)11-9-19(10-12-24)23-21(16-27(4)14-13-25-3)26-28-15-20(29)7-8-22(23)28/h19-20,25,29H,5-18H2,1-4H3
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n/an/a 555n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Protein-arginine N-methyltransferase 1


(Homo sapiens)
BDBM502079
PNG
(US11028083, Example 67b)
Show SMILES CNCCN(C)Cc1nn2CC(F)(F)Cc2c1[C@H]1CCC2(CCN(Cc3ccccc3)C2=O)CC1
Show InChI InChI=1S/C27H37F2N5O/c1-30-13-15-32(2)18-22-24(23-16-27(28,29)19-34(23)31-22)21-8-10-26(11-9-21)12-14-33(25(26)35)17-20-6-4-3-5-7-20/h3-7,21,30H,8-19H2,1-2H3/t21-,26?
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n/an/a 590n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 50 mM Hepes ...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM502017
PNG
(N1-((3-cyclohexyl-5,6- dihydro-4H-pyrrolo- [1,2-b]...)
Show SMILES CNCCN(C)Cc1nn2CCCc2c1C1CCCCC1
Show InChI InChI=1S/C17H30N4/c1-18-10-12-20(2)13-15-17(14-7-4-3-5-8-14)16-9-6-11-21(16)19-15/h14,18H,3-13H2,1-2H3
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n/an/a 654n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
PRMT1,4,6: This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 5...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
Histone-arginine methyltransferase CARM1


(Homo sapiens (Human))
BDBM502027
PNG
(N1-((3-cyclohexyl- 4,5,6,7-tetrahydro- pyrazolo[1,...)
Show SMILES CNCCN(C)Cc1nn2CCCCc2c1C1CCCCC1
Show InChI InChI=1S/C18H32N4/c1-19-11-13-21(2)14-16-18(15-8-4-3-5-9-15)17-10-6-7-12-22(17)20-16/h15,19H,3-14H2,1-2H3
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n/an/a 1.12E+3n/an/an/an/an/an/a



Board of Regents, The University of Texas System

US Patent


Assay Description
PRMT1,4,6: This enzymatic assay was performed in a 384 well, white, low volume plate (PerkinElmer, Catalog 6008289) with assay buffer consisting of 5...


US Patent US11028083 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%