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Patent code US11028085

Compile Data Set for Download or QSAR

Found 837 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500900
PNG
(7-((5-(2-(2- (dimethylami- no)propan-2- yl)morphol...)
Show SMILES CN(C)C(C)(C)C1CN(CCO1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)nc1
Show InChI InChI=1S/C29H32FN7O2/c1-29(2,35(3)4)24-17-36(11-12-39-24)19-5-8-25(31-14-19)34-22-7-6-20(21-15-33-28(38)27(21)22)23-16-32-26-13-18(30)9-10-37(23)26/h5-10,13-14,16,24H,11-12,15,17H2,1-4H3,(H,31,34)(H,33,38)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500907
PNG
(7-((5-((2R,5S)-2- (hydroxymeth- yl)-5-methoxy-pipe...)
Show SMILES CO[C@H]1CC[C@H](CO)N(C1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnn3CCCCc23)nc1
Show InChI InChI=1S/C27H32N6O3/c1-36-19-7-5-18(16-34)32(15-19)17-6-10-25(28-12-17)31-23-9-8-20(22-13-29-27(35)26(22)23)21-14-30-33-11-3-2-4-24(21)33/h6,8-10,12,14,18-19,34H,2-5,7,11,13,15-16H2,1H3,(H,28,31)(H,29,35)/t18-,19+/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500910
PNG
((S)-4-(7- fluoroimidazo [1,2-a]pyridin- 3-yl)-7-((...)
Show SMILES O[C@@]1(CCOC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)nc1
Show InChI InChI=1S/C24H20FN5O3/c25-15-5-7-30-19(12-27-21(30)9-15)16-2-3-18(22-17(16)11-28-23(22)31)29-20-4-1-14(10-26-20)24(32)6-8-33-13-24/h1-5,7,9-10,12,32H,6,8,11,13H2,(H,26,29)(H,28,31)/t24-/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500913
PNG
((R)-7-((5-(3- ((dimethylamino)- methyl)-3- hydroxy...)
Show SMILES CN(C)C[C@]1(O)CCCN(C1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3c(F)c(C)ccn23)nc1
Show InChI InChI=1S/C29H32FN7O2/c1-18-9-12-37-23(15-32-27(37)26(18)30)20-6-7-22(25-21(20)14-33-28(25)38)34-24-8-5-19(13-31-24)36-11-4-10-29(39,17-36)16-35(2)3/h5-9,12-13,15,39H,4,10-11,14,16-17H2,1-3H3,(H,31,34)(H,33,38)/t29-/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500916
PNG
((R)-4-(8-fluoro-7- methylimidazo [1,2-a]pyridin- 3...)
Show SMILES COC[C@H]1CN(CCO1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3c(F)c(C)ccn23)nc1
Show InChI InChI=1S/C27H27FN6O3/c1-16-7-8-34-22(13-30-26(34)25(16)28)19-4-5-21(24-20(19)12-31-27(24)35)32-23-6-3-17(11-29-23)33-9-10-37-18(14-33)15-36-2/h3-8,11,13,18H,9-10,12,14-15H2,1-2H3,(H,29,32)(H,31,35)/t18-/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500919
PNG
(7-((5-((3R,4R]-4- fluoro-3- hydroxypiperidin- 1-yl...)
Show SMILES Cc1ccn2c(cnc2c1F)-c1ccc(Nc2ccc(cn2)N2CC[C@@H](F)[C@H](O)C2)c2C(=O)NCc12
Show InChI InChI=1S/C26H24F2N6O2/c1-14-6-9-34-20(12-30-25(34)24(14)28)16-3-4-19(23-17(16)11-31-26(23)36)32-22-5-2-15(10-29-22)33-8-7-18(27)21(35)13-33/h2-6,9-10,12,18,21,35H,7-8,11,13H2,1H3,(H,29,32)(H,31,36)/t18-,21-/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500921
PNG
((R)-7-((5-(2- ((dimethylamino)- methyl)mor- pholin...)
Show SMILES CN(C)C[C@@H]1CN(CCO1)c1ccc(Nc2cnc(c3CNC(=O)c23)-c2ccnc3n(C)ccc23)nc1
Show InChI InChI=1S/C27H30N8O2/c1-33(2)15-18-16-35(10-11-37-18)17-4-5-23(29-12-17)32-22-14-30-25(21-13-31-27(36)24(21)22)19-6-8-28-26-20(19)7-9-34(26)3/h4-9,12,14,18H,10-11,13,15-16H2,1-3H3,(H,29,32)(H,31,36)/t18-/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500955
PNG
(4-(7- fluoroimidazo [1,2-a]pyridin- 3-yl)-7-((5- (...)
Show SMILES C[C@H](O)[C@@H]1CN(CCO1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)nc1
Show InChI InChI=1S/C26H25FN6O3/c1-15(34)22-14-32(8-9-36-22)17-2-5-23(28-11-17)31-20-4-3-18(19-12-30-26(35)25(19)20)21-13-29-24-10-16(27)6-7-33(21)24/h2-7,10-11,13,15,22,34H,8-9,12,14H2,1H3,(H,28,31)(H,30,35)/t15-,22-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500980
PNG
((R)-7-((5-(2- (methylmeth- yl)morpho- lino)pyridin...)
Show SMILES COC[C@@H]1CN(CCO1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2ncnc3n(C)ccc23)nc1
Show InChI InChI=1S/C26H27N7O3/c1-32-8-7-19-24(29-15-30-25(19)32)18-4-5-21(23-20(18)12-28-26(23)34)31-22-6-3-16(11-27-22)33-9-10-36-17(13-33)14-35-2/h3-8,11,15,17H,9-10,12-14H2,1-2H3,(H,27,31)(H,28,34)/t17-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500984
PNG
(7-((5-((3S.4S)- 4-fluoro-3- liydroxy-piperidin-1- ...)
Show SMILES O[C@H]1CN(CC[C@@H]1F)c1ccc(Nc2cnc(c3CNC(=O)c23)-c2cnc3c(F)cccn23)nc1
Show InChI InChI=1S/C24H21F2N7O2/c25-15-5-7-32(12-19(15)34)13-3-4-20(27-8-13)31-17-10-28-22(14-9-30-24(35)21(14)17)18-11-29-23-16(26)2-1-6-33(18)23/h1-4,6,8,10-11,15,19,34H,5,7,9,12H2,(H,27,31)(H,30,35)/t15-,19-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500985
PNG
(4-(7- fluoroimidazo [1,2-a]pyridin- 3-yl)-7-((5-(3...)
Show SMILES OC1(CN2CCOCC2)CCCN(C1)c1ccc(Nc2cnc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)nc1
Show InChI InChI=1S/C29H31FN8O3/c30-19-4-7-38-23(16-32-25(38)12-19)27-21-14-34-28(39)26(21)22(15-33-27)35-24-3-2-20(13-31-24)37-6-1-5-29(40,18-37)17-36-8-10-41-11-9-36/h2-4,7,12-13,15-16,40H,1,5-6,8-11,14,17-18H2,(H,31,35)(H,34,39)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500994
PNG
(US11021481, Compound I-663 | rel-(R)-4-(7- fluoroi...)
Show SMILES OC1(CC1)[C@H]1CN(CCO1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)nc1
Show InChI InChI=1S/C27H25FN6O3/c28-16-5-8-34-21(14-30-24(34)11-16)18-2-3-20(25-19(18)13-31-26(25)35)32-23-4-1-17(12-29-23)33-9-10-37-22(15-33)27(36)6-7-27/h1-5,8,11-12,14,22,36H,6-7,9-10,13,15H2,(H,29,32)(H,31,35)/t22-/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500362
PNG
(7-[[5-(4- methylpiperazin- 1-yl)-2- pyridyl]amino]...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2cnc(c3CNC(=O)c23)-c2ccnc3[nH]ccc23)nc1
Show InChI InChI=1S/C24H24N8O/c1-31-8-10-32(11-9-31)15-2-3-20(27-12-15)30-19-14-28-22(18-13-29-24(33)21(18)19)16-4-6-25-23-17(16)5-7-26-23/h2-7,12,14H,8-11,13H2,1H3,(H,25,26)(H,27,30)(H,29,33)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500363
PNG
(7-[[5-(4- methylpiperazin- 1-yl)-2- pyridyl]amino]...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2c[nH]c3ncccc23)nc1
Show InChI InChI=1S/C25H25N7O/c1-31-9-11-32(12-10-31)16-4-7-22(27-13-16)30-21-6-5-17(20-15-29-25(33)23(20)21)19-14-28-24-18(19)3-2-8-26-24/h2-8,13-14H,9-12,15H2,1H3,(H,26,28)(H,27,30)(H,29,33)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500380
PNG
(7-[[5-(4- methylpiperazin- 1-yl)-2-pyridyl]amino]-...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2ccnc3[nH]c(C)cc23)nc1
Show InChI InChI=1S/C26H27N7O/c1-16-13-20-19(7-8-27-25(20)30-16)18-4-5-22(24-21(18)15-29-26(24)34)31-23-6-3-17(14-28-23)33-11-9-32(2)10-12-33/h3-8,13-14H,9-12,15H2,1-2H3,(H,27,30)(H,28,31)(H,29,34)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501028
PNG
(7-((6- ((dimethylamino)- methyl)-5- ((3R,4R]-4- fl...)
Show SMILES CN(C)Cc1nc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)ccc1N1CC[C@@H](F)[C@H](O)C1
Show InChI InChI=1S/C28H29F2N7O2/c1-35(2)14-21-22(36-9-8-19(30)24(38)15-36)5-6-25(34-21)33-20-4-3-17(18-12-32-28(39)27(18)20)23-13-31-26-11-16(29)7-10-37(23)26/h3-7,10-11,13,19,24,38H,8-9,12,14-15H2,1-2H3,(H,32,39)(H,33,34)/t19-,24-/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500876
PNG
((S)-7-((6- ((dimethylamino)- methyl)-5- (tetrahydr...)
Show SMILES CN(C)Cc1nc(Nc2cnc(c3CNC(=O)c23)-c2ccnc3n(C)ccc23)ccc1[C@@H]1CCOC1
Show InChI InChI=1S/C27H29N7O2/c1-33(2)14-22-17(16-8-11-36-15-16)4-5-23(32-22)31-21-13-29-25(20-12-30-27(35)24(20)21)18-6-9-28-26-19(18)7-10-34(26)3/h4-7,9-10,13,16H,8,11-12,14-15H2,1-3H3,(H,30,35)(H,31,32)/t16-/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM502842
PNG
(US11028085, Compound I-708)
Show SMILES CN(C)Cc1nc(Nc2cnc(c3CNC(=O)c23)-c2ccnc3n(C)ccc23)ccc1[C@H]1CCOC1
Show InChI InChI=1S/C27H29N7O2/c1-33(2)14-22-17(16-8-11-36-15-16)4-5-23(32-22)31-21-13-29-25(20-12-30-27(35)24(20)21)18-6-9-28-26-19(18)7-10-34(26)3/h4-7,9-10,13,16H,8,11-12,14-15H2,1-3H3,(H,30,35)(H,31,32)/t16-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500385
PNG
(4-(1-methylpyrrolo] 2,3-b]pyridin- 4-yl)-7-[(5- pi...)
Show SMILES Cn1ccc2c(ccnc12)-c1ccc(Nc2ccc(cn2)N2CCNCC2)c2C(=O)NCc12
Show InChI InChI=1S/C25H25N7O/c1-31-11-7-19-18(6-8-27-24(19)31)17-3-4-21(23-20(17)15-29-25(23)33)30-22-5-2-16(14-28-22)32-12-9-26-10-13-32/h2-8,11,14,26H,9-10,12-13,15H2,1H3,(H,28,30)(H,29,33)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500388
PNG
(4-(1H-indol-3- yl)-7-[[5-(4- methylpiperazin- 1-yl...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2c[nH]c3ccccc23)nc1
Show InChI InChI=1S/C26H26N6O/c1-31-10-12-32(13-11-31)17-6-9-24(28-14-17)30-23-8-7-18(21-16-29-26(33)25(21)23)20-15-27-22-5-3-2-4-19(20)22/h2-9,14-15,27H,10-13,16H2,1H3,(H,28,30)(H,29,33)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500396
PNG
(7-[[5-(4- methylpiperazin- 1-yl)-2- pyridyl]amino]...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2cnc(c3CNC(=O)c23)-c2ccnc3[nH]c(C)cc23)nc1
Show InChI InChI=1S/C25H26N8O/c1-15-11-18-17(5-6-26-24(18)30-15)23-19-13-29-25(34)22(19)20(14-28-23)31-21-4-3-16(12-27-21)33-9-7-32(2)8-10-33/h3-6,11-12,14H,7-10,13H2,1-2H3,(H,26,30)(H,27,31)(H,29,34)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500403
PNG
(7-[[5-[4- (methylamino)- 1-piperidyl]- 2-pyridyl]a...)
Show SMILES CNC1CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2ccnc3n(C)ccc23)nc1
Show InChI InChI=1S/C27H29N7O/c1-28-17-8-13-34(14-9-17)18-3-6-24(30-15-18)32-23-5-4-19(22-16-31-27(35)25(22)23)20-7-11-29-26-21(20)10-12-33(26)2/h3-7,10-12,15,17,28H,8-9,13-14,16H2,1-2H3,(H,30,32)(H,31,35)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501038
PNG
((R)-7-((6- ((dimethylamino)- methyl)-5- (tetrahydr...)
Show SMILES CN(C)Cc1nc(Nc2ccc(c3CNC(=O)c23)-c2cnn3c(C)cccc23)ccc1[C@@H]1CCOC1
Show InChI InChI=1S/C28H30N6O2/c1-17-5-4-6-25-21(14-30-34(17)25)20-7-9-23(27-22(20)13-29-28(27)35)31-26-10-8-19(18-11-12-36-16-18)24(32-26)15-33(2)3/h4-10,14,18H,11-13,15-16H2,1-3H3,(H,29,35)(H,31,32)/t18-/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501048
PNG
((SMK7- fluoroimidazo [1,2-a]pyridin- 3-yl)-7-((6- ...)
Show SMILES Fc1ccn2c(cnc2c1)-c1ccc(Nc2ccc([C@H]3CCOC3)c(CN3CCOCC3)n2)c2C(=O)NCc12
Show InChI InChI=1S/C29H29FN6O3/c30-19-5-7-36-25(15-31-27(36)13-19)21-1-3-23(28-22(21)14-32-29(28)37)33-26-4-2-20(18-6-10-39-17-18)24(34-26)16-35-8-11-38-12-9-35/h1-5,7,13,15,18H,6,8-12,14,16-17H2,(H,32,37)(H,33,34)/t18-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501059
PNG
((S)-7-((6- ((dimethylamino)- methyl)-5- (tetrahydr...)
Show SMILES CN(C)Cc1nc(Nc2ccc(c3CNC(=O)c23)-c2cnn3cc(C)ccc23)ccc1[C@H]1CCOC1
Show InChI InChI=1S/C28H30N6O2/c1-17-4-8-25-21(13-30-34(25)14-17)20-5-7-23(27-22(20)12-29-28(27)35)31-26-9-6-19(18-10-11-36-16-18)24(32-26)15-33(2)3/h4-9,13-14,18H,10-12,15-16H2,1-3H3,(H,29,35)(H,31,32)/t18-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501062
PNG
((R)-4-(7- fluoroimidazo [1,2-a]pyridin- 3-yl)-7-((...)
Show SMILES CN(CCO)Cc1nc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)ccc1[C@@H]1CCOC1
Show InChI InChI=1S/C28H29FN6O3/c1-34(9-10-36)15-23-19(17-7-11-38-16-17)3-5-25(33-23)32-22-4-2-20(21-13-31-28(37)27(21)22)24-14-30-26-12-18(29)6-8-35(24)26/h2-6,8,12,14,17,36H,7,9-11,13,15-16H2,1H3,(H,31,37)(H,32,33)/t17-/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501067
PNG
((R)-7-((6-(((2,2- difluoroethyl)- amino)methyl)-5-...)
Show SMILES FC(F)CNCc1nc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)ccc1[C@H]1CCOC1
Show InChI InChI=1S/C27H25F3N6O2/c28-16-5-7-36-22(12-32-25(36)9-16)18-1-3-20(26-19(18)10-33-27(26)37)34-24-4-2-17(15-6-8-38-14-15)21(35-24)11-31-13-23(29)30/h1-5,7,9,12,15,23,31H,6,8,10-11,13-14H2,(H,33,37)(H,34,35)/t15-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500431
PNG
(7-[(5-piperazin-1-yl- 2-pyridyl)amino]-4- pyrazolo...)
Show SMILES O=C1NCc2c1c(Nc1ccc(cn1)N1CCNCC1)ccc2-c1cnn2ccccc12
Show InChI InChI=1S/C24H23N7O/c32-24-23-19(14-27-24)17(18-15-28-31-10-2-1-3-21(18)31)5-6-20(23)29-22-7-4-16(13-26-22)30-11-8-25-9-12-30/h1-7,10,13,15,25H,8-9,11-12,14H2,(H,26,29)(H,27,32)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500433
PNG
(7-[[5-(4-methylpiperazin- 1-yl)-2- pyridyl]amino J...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3CNCCn23)nc1
Show InChI InChI=1S/C24H28N8O/c1-30-8-10-31(11-9-30)16-2-5-21(26-12-16)29-19-4-3-17(18-13-28-24(33)23(18)19)20-14-27-22-15-25-6-7-32(20)22/h2-5,12,14,25H,6-11,13,15H2,1H3,(H,26,29)(H,28,33)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500439
PNG
(4-0,3-dimethylpyrrolo [2,3-b]pyridin-4- yl)-7-[(5-...)
Show SMILES Cc1cn(C)c2nccc(-c3ccc(Nc4ccc(cn4)N4CCNCC4)c4C(=O)NCc34)c12
Show InChI InChI=1S/C26H27N7O/c1-16-15-32(2)25-23(16)19(7-8-28-25)18-4-5-21(24-20(18)14-30-26(24)34)31-22-6-3-17(13-29-22)33-11-9-27-10-12-33/h3-8,13,15,27H,9-12,14H2,1-2H3,(H,29,31)(H,30,34)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500445
PNG
(7-[[5-(l,4- diazepan-1- yl)-2-pyridyl] amino]-4- i...)
Show SMILES O=C1NCc2c1c(Nc1ccc(cn1)N1CCCNCC1)ccc2-c1cnc2ccccn12
Show InChI InChI=1S/C25H25N7O/c33-25-24-19(15-29-25)18(21-16-28-23-4-1-2-12-32(21)23)6-7-20(24)30-22-8-5-17(14-27-22)31-11-3-9-26-10-13-31/h1-2,4-8,12,14,16,26H,3,9-11,13,15H2,(H,27,30)(H,29,33)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500453
PNG
(7-[[5-(4- methylpiperazin- 1-yl)-2-pyridyl] amino]...)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnn3cccnc23)nc1
Show InChI InChI=1S/C24H24N8O/c1-30-9-11-31(12-10-30)16-3-6-21(26-13-16)29-20-5-4-17(18-14-27-24(33)22(18)20)19-15-28-32-8-2-7-25-23(19)32/h2-8,13,15H,9-12,14H2,1H3,(H,26,29)(H,27,33)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500456
PNG
(4-(1-methylpyrrolo [2,3-b]pyridin- 4-yl)-7-[[3-(4-...)
Show SMILES Cn1ccc2c(ccnc12)-c1ccc(Nc2cc(n[nH]2)C2CCNCC2)c2C(=O)NCc12
Show InChI InChI=1S/C24H25N7O/c1-31-11-7-17-16(6-10-26-23(17)31)15-2-3-19(22-18(15)13-27-24(22)32)28-21-12-20(29-30-21)14-4-8-25-9-5-14/h2-3,6-7,10-12,14,25H,4-5,8-9,13H2,1H3,(H,27,32)(H2,28,29,30)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501094
PNG
((S)-7-((6- ((dimethylamino)- methyl)-5- (tetrahydr...)
Show SMILES CN(C)Cc1nc(Nc2cnc(c3CNC(=O)c23)-c2ccnc3[nH]ccc23)ccc1[C@@H]1CCOC1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501100
PNG
((S)-4-(7- fluoroimidazo [1,2-a]pyridin- 3-yl)-7-((...)
Show SMILES Fc1ccn2c(cnc2c1)-c1ccc(Nc2ccc([C@H]3CCOC3)c(n2)N2CCNCC2)c2C(=O)NCc12
Show InChI InChI=1S/C28H28FN7O2/c29-18-5-9-36-23(15-31-25(36)13-18)20-1-3-22(26-21(20)14-32-28(26)37)33-24-4-2-19(17-6-12-38-16-17)27(34-24)35-10-7-30-8-11-35/h1-5,9,13,15,17,30H,6-8,10-12,14,16H2,(H,32,37)(H,33,34)/t17-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501117
PNG
(4-(7- fluoroimidazo [1,2-a]pyridin- 3-yl)-74(6- ((...)
Show SMILES CO[C@H]1CCN(Cc2nc(Nc3ccc(c4CNC(=O)c34)-c3cnc4cc(F)ccn34)ccc2C2CCOC2)C1
Show InChI InChI=1S/C30H31FN6O3/c1-39-20-7-9-36(15-20)16-25-21(18-8-11-40-17-18)3-5-27(35-25)34-24-4-2-22(23-13-33-30(38)29(23)24)26-14-32-28-12-19(31)6-10-37(26)28/h2-6,10,12,14,18,20H,7-9,11,13,15-17H2,1H3,(H,33,38)(H,34,35)/t18?,20-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500736
PNG
(7-((5-(4- hydroxypipen din-1-yl)pyridin-2- yl)amin...)
Show SMILES OC1CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3ccccn23)nc1
Show InChI InChI=1S/C25H24N6O2/c32-17-8-11-30(12-9-17)16-4-7-22(26-13-16)29-20-6-5-18(19-14-28-25(33)24(19)20)21-15-27-23-3-1-2-10-31(21)23/h1-7,10,13,15,17,32H,8-9,11-12,14H2,(H,26,29)(H,28,33)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500472
PNG
(7-[[5-(4-hydroxy-1- piperidyl)-2-pyridyl] amino]-4...)
Show SMILES OC1CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnn3ccccc23)nc1
Show InChI InChI=1S/C25H24N6O2/c32-17-8-11-30(12-9-17)16-4-7-23(26-13-16)29-21-6-5-18(20-14-27-25(33)24(20)21)19-15-28-31-10-2-1-3-22(19)31/h1-7,10,13,15,17,32H,8-9,11-12,14H2,(H,26,29)(H,27,33)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500481
PNG
(7-[[5-(4-hydroxy-1- piperidyl)-2- pyridyl]amino]-4...)
Show SMILES OC1CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(ccn23)C(F)(F)F)nc1
Show InChI InChI=1S/C26H23F3N6O2/c27-26(28,29)15-5-10-35-21(14-31-23(35)11-15)18-2-3-20(24-19(18)13-32-25(24)37)33-22-4-1-16(12-30-22)34-8-6-17(36)7-9-34/h1-5,10-12,14,17,36H,6-9,13H2,(H,30,33)(H,32,37)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM502291
PNG
(US11028085, Compound I-144)
Show SMILES Cn1ccc2c(ncnc12)-c1ccc(Nc2ccc(cn2)N2CCC(O)CC2)c2C(=O)NCc12
Show InChI InChI=1S/C25H25N7O2/c1-31-9-8-18-23(28-14-29-24(18)31)17-3-4-20(22-19(17)13-27-25(22)34)30-21-5-2-15(12-26-21)32-10-6-16(33)7-11-32/h2-5,8-9,12,14,16,33H,6-7,10-11,13H2,1H3,(H,26,30)(H,27,34)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500494
PNG
(4-imidazo[1,2- a]pyrazin-3- yl-7-[(5- morpholino-2...)
Show SMILES O=C1NCc2c1c(Nc1ccc(cn1)N1CCOCC1)ccc2-c1cnc2cnccn12
Show InChI InChI=1S/C23H21N7O2/c31-23-22-17(12-27-23)16(19-13-26-21-14-24-5-6-30(19)21)2-3-18(22)28-20-4-1-15(11-25-20)29-7-9-32-10-8-29/h1-6,11,13-14H,7-10,12H2,(H,25,28)(H,27,31)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501131
PNG
((R)-7-((6- ((dimethylamino)- methyl)-5-(3- hydroxy...)
Show SMILES CN(C)Cc1nc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)ccc1[C@@]1(O)CCOC1
Show InChI InChI=1S/C27H27FN6O3/c1-33(2)14-21-19(27(36)8-10-37-15-27)4-6-23(32-21)31-20-5-3-17(18-12-30-26(35)25(18)20)22-13-29-24-11-16(28)7-9-34(22)24/h3-7,9,11,13,36H,8,10,12,14-15H2,1-2H3,(H,30,35)(H,31,32)/t27-/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501132
PNG
((S)-7-((6- ((dimethylamino)- methyl)-5-(3- hydroxy...)
Show SMILES CN(C)Cc1nc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)ccc1[C@]1(O)CCOC1
Show InChI InChI=1S/C27H27FN6O3/c1-33(2)14-21-19(27(36)8-10-37-15-27)4-6-23(32-21)31-20-5-3-17(18-12-30-26(35)25(18)20)22-13-29-24-11-16(28)7-9-34(22)24/h3-7,9,11,13,36H,8,10,12,14-15H2,1-2H3,(H,30,35)(H,31,32)/t27-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501134
PNG
((S)-7-((6- ((dimetlnlamino)- methyl)-5- ((tetrahyd...)
Show SMILES CN(C)Cc1nc(Nc2cnc(c3CNC(=O)c23)-c2ccnc3n(C)ccc23)ccc1O[C@H]1CCOC1
Show InChI InChI=1S/C27H29N7O3/c1-33(2)14-21-22(37-16-8-11-36-15-16)4-5-23(32-21)31-20-13-29-25(19-12-30-27(35)24(19)20)17-6-9-28-26-18(17)7-10-34(26)3/h4-7,9-10,13,16H,8,11-12,14-15H2,1-3H3,(H,30,35)(H,31,32)/t16-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501138
PNG
(7-((6-(((R)-3- hydroxypyrroli- din-1- yl)methyl)-5...)
Show SMILES Cn1ccc2c(ccnc12)-c1ncc(Nc2ccc([C@H]3CCOC3)c(CN3CC[C@@H](O)C3)n2)c2C(=O)NCc12
Show InChI InChI=1S/C29H31N7O3/c1-35-9-6-21-20(4-8-30-28(21)35)27-22-12-32-29(38)26(22)23(13-31-27)33-25-3-2-19(17-7-11-39-16-17)24(34-25)15-36-10-5-18(37)14-36/h2-4,6,8-9,13,17-18,37H,5,7,10-12,14-16H2,1H3,(H,32,38)(H,33,34)/t17-,18+/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501139
PNG
(7-((6-(((S)-3- hydroxypyrroli- din-1- yl)methyl)-5...)
Show SMILES Cn1ccc2c(ccnc12)-c1ncc(Nc2ccc([C@@H]3CCOC3)c(CN3CC[C@H](O)C3)n2)c2C(=O)NCc12
Show InChI InChI=1S/C29H31N7O3/c1-35-9-6-21-20(4-8-30-28(21)35)27-22-12-32-29(38)26(22)23(13-31-27)33-25-3-2-19(17-7-11-39-16-17)24(34-25)15-36-10-5-18(37)14-36/h2-4,6,8-9,13,17-18,37H,5,7,10-12,14-16H2,1H3,(H,32,38)(H,33,34)/t17-,18+/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501154
PNG
(4-(7- fluoroimidazo [1,2-a]pyridin- 3-yl)-7-((6- (...)
Show SMILES OC[C@H]1CCCN1Cc1nc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)ccc1[C@@H]1CCOC1
Show InChI InChI=1S/C30H31FN6O3/c31-19-7-10-37-26(14-32-28(37)12-19)22-3-5-24(29-23(22)13-33-30(29)39)34-27-6-4-21(18-8-11-40-17-18)25(35-27)15-36-9-1-2-20(36)16-38/h3-7,10,12,14,18,20,38H,1-2,8-9,11,13,15-17H2,(H,33,39)(H,34,35)/t18-,20-/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM501155
PNG
(4-(7- fluoroimidazo [1,2-a]pyridin- 3-yl)-7-((6- (...)
Show SMILES OC[C@@H]1CCCN1Cc1nc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)ccc1[C@H]1CCOC1
Show InChI InChI=1S/C30H31FN6O3/c31-19-7-10-37-26(14-32-28(37)12-19)22-3-5-24(29-23(22)13-33-30(29)39)34-27-6-4-21(18-8-11-40-17-18)25(35-27)15-36-9-1-2-20(36)16-38/h3-7,10,12,14,18,20,38H,1-2,8-9,11,13,15-17H2,(H,33,39)(H,34,35)/t18-,20-/m0/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM500512
PNG
(7-[[5-[(3R)-3- hydroxy-1- piperipyl]-2- pyripyl]am...)
Show SMILES O[C@@H]1CCCN(C1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cnccn23)nc1
Show InChI InChI=1S/C24H23N7O2/c32-16-2-1-8-30(14-16)15-3-6-21(26-10-15)29-19-5-4-17(18-11-28-24(33)23(18)19)20-12-27-22-13-25-7-9-31(20)22/h3-7,9-10,12-13,16,32H,1-2,8,11,14H2,(H,26,29)(H,28,33)/t16-/m1/s1
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 1


(Homo sapiens (Human))
BDBM502324
PNG
(US11028085, Compound I-177)
Show SMILES OCc1ccn2c(cnc2c1)-c1ccc(Nc2ccc(cn2)N2CCC(O)CC2)c2C(=O)NCc12
Show InChI InChI=1S/C26H26N6O3/c33-15-16-5-10-32-22(14-28-24(32)11-16)19-2-3-21(25-20(19)13-29-26(25)35)30-23-4-1-17(12-27-23)31-8-6-18(34)7-9-31/h1-5,10-12,14,18,33-34H,6-9,13,15H2,(H,27,30)(H,29,35)
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Nimbus Saturn, Inc.

US Patent


Assay Description
HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...


US Patent US11028085 (2021)

More data for this
Ligand-Target Pair
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