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Patent code US11028093

Compile Data Set for Download or QSAR

Found 867 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325515
PNG
((1- hydroxycyclopropyl)(3- (4-(4-(1-(pentan-3-yl)-...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CN(C1)C(=O)C1(O)CC1
Show InChI InChI=1S/C24H28N8O2/c1-3-18(4-2)30-12-17(10-27-30)22-21-5-8-25-32(21)15-20(28-22)16-9-26-31(11-16)19-13-29(14-19)23(33)24(34)6-7-24/h5,8-12,15,18-19,34H,3-4,6-7,13-14H2,1-2H3
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325375
PNG
(6-(1-(1-(methylsulfonyl)azetidin-3-yl)-1H-pyrazol-...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CN(C1)S(C)(=O)=O
Show InChI InChI=1S/C21H26N8O2S/c1-4-17(5-2)27-11-16(9-24-27)21-20-6-7-22-29(20)14-19(25-21)15-8-23-28(10-15)18-12-26(13-18)32(3,30)31/h6-11,14,17-18H,4-5,12-13H2,1-3H3
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM502821
PNG
(US11028093, Example 118 | trans-4-(4-(4-(1-(pentan...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C23H29N7O/c1-3-18(4-2)28-14-17(12-26-28)23-22-9-10-24-30(22)15-21(27-23)16-11-25-29(13-16)19-5-7-20(31)8-6-19/h9-15,18-20,31H,3-8H2,1-2H3/t19-,20-
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM502873
PNG
((1s,3 s)-1-methyl-3-(4-(4-(1-(pentan-3-yl)-1H-pyra...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)[C@H]1C[C@@](C)(O)C1
Show InChI InChI=1S/C22H27N7O/c1-4-17(5-2)27-13-16(11-25-27)21-20-6-7-23-29(20)14-19(26-21)15-10-24-28(12-15)18-8-22(3,30)9-18/h6-7,10-14,17-18,30H,4-5,8-9H2,1-3H3/t18-,22+
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM502874
PNG
((1s,3s)-1-(hydroxymethyl)-3-(4-(4-(1-(pentan-3-yl)...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)[C@H]1C[C@](O)(CO)C1
Show InChI InChI=1S/C22H27N7O2/c1-3-17(4-2)27-12-16(10-25-27)21-20-5-6-23-29(20)13-19(26-21)15-9-24-28(11-15)18-7-22(31,8-18)14-30/h5-6,9-13,17-18,30-31H,3-4,7-8,14H2,1-2H3/t18-,22+
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325371
PNG
(2-methoxy-1-(4-(4-(4-(1- (pentan-3-yl)-1H-pyrazol-...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CCN(CC1)C(=O)COC
Show InChI InChI=1S/C25H32N8O2/c1-4-20(5-2)31-15-19(13-28-31)25-23-6-9-26-33(23)16-22(29-25)18-12-27-32(14-18)21-7-10-30(11-8-21)24(34)17-35-3/h6,9,12-16,20-21H,4-5,7-8,10-11,17H2,1-3H3
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325457
PNG
(US10189845, Example 119 | US10730880, Example 119 ...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1C[C@H](O)C1
Show InChI InChI=1S/C21H25N7O/c1-3-16(4-2)26-12-15(10-24-26)21-20-5-6-22-28(20)13-19(25-21)14-9-23-27(11-14)17-7-18(29)8-17/h5-6,9-13,16-18,29H,3-4,7-8H2,1-2H3/t17?,18-
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325470
PNG
(US10189845, Example 132A | US10189845, Example 133...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)[C@@H]1C[C@H](O)[C@H](O)C1
Show InChI InChI=1S/C22H27N7O2/c1-3-16(4-2)27-12-15(10-25-27)22-19-5-6-23-29(19)13-18(26-22)14-9-24-28(11-14)17-7-20(30)21(31)8-17/h5-6,9-13,16-17,20-21,30-31H,3-4,7-8H2,1-2H3/t17-,20+,21-
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325371
PNG
(2-methoxy-1-(4-(4-(4-(1- (pentan-3-yl)-1H-pyrazol-...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CCN(CC1)C(=O)COC
Show InChI InChI=1S/C25H32N8O2/c1-4-20(5-2)31-15-19(13-28-31)25-23-6-9-26-33(23)16-22(29-25)18-12-27-32(14-18)21-7-10-30(11-8-21)24(34)17-35-3/h6,9,12-16,20-21H,4-5,7-8,10-11,17H2,1-3H3
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325374
PNG
(2-amino-1-(4-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4-y...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CCN(CC1)C(=O)CN
Show InChI InChI=1S/C24H31N9O/c1-3-19(4-2)31-15-18(13-28-31)24-22-5-8-26-33(22)16-21(29-24)17-12-27-32(14-17)20-6-9-30(10-7-20)23(34)11-25/h5,8,12-16,19-20H,3-4,6-7,9-11,25H2,1-2H3
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325372
PNG
(N-methyl-4-(4-(4-(1- (pentan-3-yl)-1H-pyrazol- 4-y...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CCN(CC1)C(=O)NC
Show InChI InChI=1S/C24H31N9O/c1-4-19(5-2)31-15-18(13-28-31)23-22-6-9-26-33(22)16-21(29-23)17-12-27-32(14-17)20-7-10-30(11-8-20)24(34)25-3/h6,9,12-16,19-20H,4-5,7-8,10-11H2,1-3H3,(H,25,34)
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325374
PNG
(2-amino-1-(4-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4-y...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CCN(CC1)C(=O)CN
Show InChI InChI=1S/C24H31N9O/c1-3-19(4-2)31-15-18(13-28-31)24-22-5-8-26-33(22)16-21(29-24)17-12-27-32(14-17)20-6-9-30(10-7-20)23(34)11-25/h5,8,12-16,19-20H,3-4,6-7,9-11,25H2,1-2H3
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325386
PNG
(4-(1-(3-ethyl-1-((trifluoromethyl)sulfonyl)azetidi...)
Show SMILES CCC1(CN(C1)S(=O)(=O)C(F)(F)F)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C)c1
Show InChI InChI=1S/C19H19F3N8O2S/c1-3-18(11-28(12-18)33(31,32)19(20,21)22)30-9-14(7-25-30)17-16-4-5-23-29(16)10-15(26-17)13-6-24-27(2)8-13/h4-10H,3,11-12H2,1-2H3
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325369
PNG
(1-(4-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4-yl)pyrazo...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CCN(CC1)C(C)=O
Show InChI InChI=1S/C24H30N8O/c1-4-20(5-2)30-15-19(13-27-30)24-23-6-9-25-32(23)16-22(28-24)18-12-26-31(14-18)21-7-10-29(11-8-21)17(3)33/h6,9,12-16,20-21H,4-5,7-8,10-11H2,1-3H3
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325370
PNG
(6-(1-(1- (methylsulfonyl)piperidin- 4-yl)-1H-pyraz...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C23H30N8O2S/c1-4-19(5-2)29-15-18(13-26-29)23-22-6-9-24-31(22)16-21(27-23)17-12-25-30(14-17)20-7-10-28(11-8-20)34(3,32)33/h6,9,12-16,19-20H,4-5,7-8,10-11H2,1-3H3
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325386
PNG
(4-(1-(3-ethyl-1-((trifluoromethyl)sulfonyl)azetidi...)
Show SMILES CCC1(CN(C1)S(=O)(=O)C(F)(F)F)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C)c1
Show InChI InChI=1S/C19H19F3N8O2S/c1-3-18(11-28(12-18)33(31,32)19(20,21)22)30-9-14(7-25-30)17-16-4-5-23-29(16)10-15(26-17)13-6-24-27(2)8-13/h4-10H,3,11-12H2,1-2H3
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325545
PNG
(US10189845, Example 207A | US10730880, Example 207...)
Show SMILES CC[C@@H]1CCC[C@@H]1n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@@H](O)CO)c1
Show InChI InChI=1S/C22H27N7O2/c1-2-15-4-3-5-20(15)28-11-17(9-25-28)22-21-6-7-23-29(21)13-19(26-22)16-8-24-27(10-16)12-18(31)14-30/h6-11,13,15,18,20,30-31H,2-5,12,14H2,1H3/t15-,18-,20+/m1/s1
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325351
PNG
(3-(4-(4-(1-(pentan-3-yl)-1H- pyrazol-4-yl)pyrazolo...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CS(=O)(=O)C1
Show InChI InChI=1S/C20H23N7O2S/c1-3-16(4-2)25-10-15(8-23-25)20-19-5-6-21-27(19)11-18(24-20)14-7-22-26(9-14)17-12-30(28,29)13-17/h5-11,16-17H,3-4,12-13H2,1-2H3
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325423
PNG
((R)-2-(4-(4-(1-(sec- butyl)-1H-pyrazol-4- yl)pyraz...)
Show SMILES CC[C@@H](C)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C(CO)CO
Show InChI InChI=1S/C19H23N7O2/c1-3-13(2)24-9-15(7-21-24)19-18-4-5-20-26(18)10-17(23-19)14-6-22-25(8-14)16(11-27)12-28/h4-10,13,16,27-28H,3,11-12H2,1-2H3/t13-/m1/s1
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325424
PNG
((S)-3-(4-(4-(1-((S)- pentan-2-yl)-1H-pyrazol- 4-yl...)
Show SMILES CCC[C@H](C)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@H](O)CO)c1
Show InChI InChI=1S/C20H25N7O2/c1-3-4-14(2)26-10-16(8-23-26)20-19-5-6-21-27(19)12-18(24-20)15-7-22-25(9-15)11-17(29)13-28/h5-10,12,14,17,28-29H,3-4,11,13H2,1-2H3/t14-,17-/m0/s1
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325514
PNG
(2-hydroxy-2-methyl-1-(3- (4-(4-(1-(pentan-3-yl)- 1...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CN(C1)C(=O)C(C)(C)O
Show InChI InChI=1S/C24H30N8O2/c1-5-18(6-2)30-12-17(10-27-30)22-21-7-8-25-32(21)15-20(28-22)16-9-26-31(11-16)19-13-29(14-19)23(33)24(3,4)34/h7-12,15,18-19,34H,5-6,13-14H2,1-4H3
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325370
PNG
(6-(1-(1- (methylsulfonyl)piperidin- 4-yl)-1H-pyraz...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C23H30N8O2S/c1-4-19(5-2)29-15-18(13-26-29)23-22-6-9-24-31(22)16-21(27-23)17-12-25-30(14-17)20-7-10-28(11-8-20)34(3,32)33/h6,9,12-16,19-20H,4-5,7-8,10-11H2,1-3H3
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325493
PNG
(US10189845, Example 155A | US10730880, Example 155...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)[C@@H](C)[C@H](C)O
Show InChI InChI=1S/C21H27N7O/c1-5-18(6-2)27-12-17(10-24-27)21-20-7-8-22-28(20)13-19(25-21)16-9-23-26(11-16)14(3)15(4)29/h7-15,18,29H,5-6H2,1-4H3/t14-,15-/m0/s1
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n/an/a 55n/an/an/an/an/an/a



ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325495
PNG
(US10189845, Example 157A | US10730880, Example 157...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)[C@@H](C)[C@@H](C)O
Show InChI InChI=1S/C21H27N7O/c1-5-18(6-2)27-12-17(10-24-27)21-20-7-8-22-28(20)13-19(25-21)16-9-23-26(11-16)14(3)15(4)29/h7-15,18,29H,5-6H2,1-4H3/t14-,15+/m0/s1
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM325496
PNG
(US10189845, Example 158B | US10730880, Example 158...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)[C@H](C)[C@H](C)O
Show InChI InChI=1S/C21H27N7O/c1-5-18(6-2)27-12-17(10-24-27)21-20-7-8-22-28(20)13-19(25-21)16-9-23-26(11-16)14(3)15(4)29/h7-15,18,29H,5-6H2,1-4H3/t14-,15+/m1/s1
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n/an/a 55n/an/an/an/an/an/a



ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325499
PNG
(US10189845, Example 161 | US10730880, Example 161 ...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)[C@H]1C[C@H](O)C1
Show InChI InChI=1S/C21H25N7O/c1-3-16(4-2)26-12-15(10-24-26)21-20-5-6-22-28(20)13-19(25-21)14-9-23-27(11-14)17-7-18(29)8-17/h5-6,9-13,16-18,29H,3-4,7-8H2,1-2H3/t17-,18-
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325516
PNG
((cis-3- hydroxycyclobutyl)(3- (4-(4-(1-(pentan-3-y...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CN(C1)C(=O)C1C[C@H](O)C1
Show InChI InChI=1S/C25H30N8O2/c1-3-19(4-2)31-12-18(10-28-31)24-23-5-6-26-33(23)15-22(29-24)17-9-27-32(11-17)20-13-30(14-20)25(35)16-7-21(34)8-16/h5-6,9-12,15-16,19-21,34H,3-4,7-8,13-14H2,1-2H3/t16?,21-
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325530
PNG
((1-((4-(4-(1-(pentan-3-yl)-1H- pyrazol-4-yl)pyrazo...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CC2(CO)CC2)c1
Show InChI InChI=1S/C22H27N7O/c1-3-18(4-2)28-12-17(10-25-28)21-20-5-8-23-29(20)13-19(26-21)16-9-24-27(11-16)14-22(15-30)6-7-22/h5,8-13,18,30H,3-4,6-7,14-15H2,1-2H3
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325538
PNG
(US10189845, Example 200A | US10730880, Example 200...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@@H](O)CCO)c1
Show InChI InChI=1S/C21H27N7O2/c1-3-17(4-2)27-12-16(10-24-27)21-20-5-7-22-28(20)14-19(25-21)15-9-23-26(11-15)13-18(30)6-8-29/h5,7,9-12,14,17-18,29-30H,3-4,6,8,13H2,1-2H3/t18-/m0/s1
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325341
PNG
(4-(2-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4-yl)pyrazo...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CCN2CCOCC2)c1
Show InChI InChI=1S/C23H30N8O/c1-3-20(4-2)30-16-19(14-26-30)23-22-5-6-24-31(22)17-21(27-23)18-13-25-29(15-18)8-7-28-9-11-32-12-10-28/h5-6,13-17,20H,3-4,7-12H2,1-2H3
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325541
PNG
(US10189845, Example 203B | US10730880, Example 203...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@](C)(O)CO)c1
Show InChI InChI=1S/C21H27N7O2/c1-4-17(5-2)27-11-16(9-24-27)20-19-6-7-22-28(19)12-18(25-20)15-8-23-26(10-15)13-21(3,30)14-29/h6-12,17,29-30H,4-5,13-14H2,1-3H3/t21-/m0/s1
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325545
PNG
(US10189845, Example 207A | US10730880, Example 207...)
Show SMILES CC[C@@H]1CCC[C@@H]1n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@@H](O)CO)c1
Show InChI InChI=1S/C22H27N7O2/c1-2-15-4-3-5-20(15)28-11-17(9-25-28)22-21-6-7-23-29(21)13-19(26-22)16-8-24-27(10-16)12-18(31)14-30/h6-11,13,15,18,20,30-31H,2-5,12,14H2,1H3/t15-,18-,20+/m1/s1
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325551
PNG
(US10189845, Example 213B | US10189845, Example 214...)
Show SMILES CCC(C1CC1)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@@H](O)CO)c1
Show InChI InChI=1S/C21H25N7O2/c1-2-19(14-3-4-14)27-10-16(8-24-27)21-20-5-6-22-28(20)12-18(25-21)15-7-23-26(9-15)11-17(30)13-29/h5-10,12,14,17,19,29-30H,2-4,11,13H2,1H3/t17-,19?/m1/s1
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325553
PNG
(US10189845, Example 215B | US10730880, Example 215...)
Show SMILES CCC(C1CC1)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C(CO)CO
Show InChI InChI=1S/C21H25N7O2/c1-2-19(14-3-4-14)27-10-16(8-24-27)21-20-5-6-22-28(20)11-18(25-21)15-7-23-26(9-15)17(12-29)13-30/h5-11,14,17,19,29-30H,2-4,12-13H2,1H3
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325345
PNG
(6-(1-(3- (methylsulfonyl)propyl)-1H- pyrazol-4-yl)...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CCCS(C)(=O)=O)c1
Show InChI InChI=1S/C21H27N7O2S/c1-4-18(5-2)27-14-17(12-24-27)21-20-7-8-22-28(20)15-19(25-21)16-11-23-26(13-16)9-6-10-31(3,29)30/h7-8,11-15,18H,4-6,9-10H2,1-3H3
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325348
PNG
(N,N-dimethyl-2-(4-(4-(1- (pentan-3-yl)-1H-pyrazol-...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CCN(C)C)c1
Show InChI InChI=1S/C21H28N8/c1-5-18(6-2)28-14-17(12-24-28)21-20-7-8-22-29(20)15-19(25-21)16-11-23-27(13-16)10-9-26(3)4/h7-8,11-15,18H,5-6,9-10H2,1-4H3
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM325352
PNG
((R)-2-methyl-3-(4-(4-(1- (pentan-3-yl)-1H-pyrazol-...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@@H](C)CO)c1
Show InChI InChI=1S/C21H27N7O/c1-4-18(5-2)27-12-17(9-24-27)21-20-6-7-22-28(20)13-19(25-21)16-8-23-26(11-16)10-15(3)14-29/h6-9,11-13,15,18,29H,4-5,10,14H2,1-3H3/t15-/m1/s1
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325355
PNG
((S)-5-((4-(4-(1-(pentan-3- yl)-1H-pyrazol-4- yl)py...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@@H]2CCC(=O)N2)c1
Show InChI InChI=1S/C22H26N8O/c1-3-18(4-2)29-12-16(10-25-29)22-20-7-8-23-30(20)14-19(27-22)15-9-24-28(11-15)13-17-5-6-21(31)26-17/h7-12,14,17-18H,3-6,13H2,1-2H3,(H,26,31)/t17-/m0/s1
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325356
PNG
((R)-5-((4-(4-(1-(pentan-3- yl)-1H-pyrazol-4- yl)py...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@H]2CCC(=O)N2)c1
Show InChI InChI=1S/C22H26N8O/c1-3-18(4-2)29-12-16(10-25-29)22-20-7-8-23-30(20)14-19(27-22)15-9-24-28(11-15)13-17-5-6-21(31)26-17/h7-12,14,17-18H,3-6,13H2,1-2H3,(H,26,31)/t17-/m1/s1
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325356
PNG
((R)-5-((4-(4-(1-(pentan-3- yl)-1H-pyrazol-4- yl)py...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@H]2CCC(=O)N2)c1
Show InChI InChI=1S/C22H26N8O/c1-3-18(4-2)29-12-16(10-25-29)22-20-7-8-23-30(20)14-19(27-22)15-9-24-28(11-15)13-17-5-6-21(31)26-17/h7-12,14,17-18H,3-6,13H2,1-2H3,(H,26,31)/t17-/m1/s1
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n/an/a 55n/an/an/an/an/an/a



ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325360
PNG
(6-(1-(2-(methylsulfonyl)ethyl)-1H-pyrazol-4-yl)-4-...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CCS(C)(=O)=O)c1
Show InChI InChI=1S/C20H25N7O2S/c1-4-17(5-2)26-13-16(11-23-26)20-19-6-7-21-27(19)14-18(24-20)15-10-22-25(12-15)8-9-30(3,28)29/h6-7,10-14,17H,4-5,8-9H2,1-3H3
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n/an/a 55n/an/an/an/an/an/a



ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325363
PNG
(4-(1-(pentan-3-yl)-1H-pyrazol-4-yl)-6-(1-(piperidi...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C22H28N8/c1-3-18(4-2)28-14-17(12-26-28)22-21-7-10-24-30(21)15-20(27-22)16-11-25-29(13-16)19-5-8-23-9-6-19/h7,10-15,18-19,23H,3-6,8-9H2,1-2H3
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n/an/a 55n/an/an/an/an/an/a



ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325363
PNG
(4-(1-(pentan-3-yl)-1H-pyrazol-4-yl)-6-(1-(piperidi...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C22H28N8/c1-3-18(4-2)28-14-17(12-26-28)22-21-7-10-24-30(21)15-20(27-22)16-11-25-29(13-16)19-5-8-23-9-6-19/h7,10-15,18-19,23H,3-6,8-9H2,1-2H3
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n/an/a 55n/an/an/an/an/an/a



ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325375
PNG
(6-(1-(1-(methylsulfonyl)azetidin-3-yl)-1H-pyrazol-...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)C1CN(C1)S(C)(=O)=O
Show InChI InChI=1S/C21H26N8O2S/c1-4-17(5-2)27-11-16(9-24-27)21-20-6-7-22-29(20)14-19(25-21)15-8-23-28(10-15)18-12-26(13-18)32(3,30)31/h6-11,14,17-18H,4-5,12-13H2,1-3H3
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n/an/a 55n/an/an/an/an/an/a



ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325393
PNG
((S)-3-(4-(4-(1-(pentan-3-yl)-1H-pyrazol-4-yl)pyraz...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@H](O)CO)c1
Show InChI InChI=1S/C20H25N7O2/c1-3-16(4-2)26-10-15(8-23-26)20-19-5-6-21-27(19)12-18(24-20)14-7-22-25(9-14)11-17(29)13-28/h5-10,12,16-17,28-29H,3-4,11,13H2,1-2H3/t17-/m0/s1
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n/an/a 55n/an/an/an/an/an/a



ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325401
PNG
(4-(4-(4-(1-(pentan-3-yl)- 1H-pyrazol-4- yl)pyrazol...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(CC(O)CCO)c1
Show InChI InChI=1S/C21H27N7O2/c1-3-17(4-2)27-12-16(10-24-27)21-20-5-7-22-28(20)14-19(25-21)15-9-23-26(11-15)13-18(30)6-8-29/h5,7,9-12,14,17-18,29-30H,3-4,6,8,13H2,1-2H3
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n/an/a 55n/an/an/an/an/an/a



ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325408
PNG
((S)-3-(4-(4-(1-((S)-sec- butyl)-1H-pyrazol-4- yl)p...)
Show SMILES CC[C@H](C)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@H](O)CO)c1
Show InChI InChI=1S/C19H23N7O2/c1-3-13(2)25-9-15(7-22-25)19-18-4-5-20-26(18)11-17(23-19)14-6-21-24(8-14)10-16(28)12-27/h4-9,11,13,16,27-28H,3,10,12H2,1-2H3/t13-,16-/m0/s1
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n/an/a 55n/an/an/an/an/an/a



ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM325411
PNG
((R)-3-(4-(4-(1-((R)-pentan- 2-yl)-1H-pyrazol-4- yl...)
Show SMILES CCC[C@@H](C)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@@H](O)CO)c1
Show InChI InChI=1S/C20H25N7O2/c1-3-4-14(2)26-10-16(8-23-26)20-19-5-6-21-27(19)12-18(24-20)15-7-22-25(9-15)11-17(29)13-28/h5-10,12,14,17,28-29H,3-4,11,13H2,1-2H3/t14-,17-/m1/s1
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n/an/a 55n/an/an/an/an/an/a



ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325417
PNG
((2R)-3-(4-(4-(1-(1-(3,3- difluorocyclobutyl)propyl...)
Show SMILES CCC(C1CC(F)(F)C1)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(C[C@@H](O)CO)c1
Show InChI InChI=1S/C22H25F2N7O2/c1-2-19(14-5-22(23,24)6-14)30-10-16(8-27-30)21-20-3-4-25-31(20)12-18(28-21)15-7-26-29(9-15)11-17(33)13-32/h3-4,7-10,12,14,17,19,32-33H,2,5-6,11,13H2,1H3/t17-,19?/m1/s1
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM325429
PNG
(US10189845, Example 91A | US10730880, Example 91 |...)
Show SMILES CCC(CC)n1cc(cn1)-c1nc(cn2nccc12)-c1cnn(c1)[C@@H](C)[C@@H](O)CO
Show InChI InChI=1S/C21H27N7O2/c1-4-17(5-2)27-11-16(9-24-27)21-19-6-7-22-28(19)12-18(25-21)15-8-23-26(10-15)14(3)20(30)13-29/h6-12,14,17,20,29-30H,4-5,13H2,1-3H3/t14-,20-/m0/s1
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ARRAY BIOPHARMA INC.; CELGENE CORPORATION

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US11028093 (2021)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%