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Patent code US11033539

Compile Data Set for Download or QSAR

Found 1210 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM502996
PNG
(N-[2-(1-benzylpiperidin-4-yl)ethyl]-4-[4- (trifluo...)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1ccc(cc1)C(=O)NCCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C28H29F3N2O2/c29-28(30,31)35-26-12-10-24(11-13-26)23-6-8-25(9-7-23)27(34)32-17-14-21-15-18-33(19-16-21)20-22-4-2-1-3-5-22/h1-13,21H,14-20H2,(H,32,34)
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM503082
PNG
(N-[2-(1-benzylpiperidin-4-yl)ethyl]-3-methyl-1-[3-...)
Show SMILES CC1CN(CCC1C(=O)NCCC1CCN(Cc2ccccc2)CC1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C28H36F3N3O2/c1-21-19-34(24-8-5-9-25(18-24)36-28(29,30)31)17-13-26(21)27(35)32-14-10-22-11-15-33(16-12-22)20-23-6-3-2-4-7-23/h2-9,18,21-22,26H,10-17,19-20H2,1H3,(H,32,35)
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM503121
PNG
(N-[2-(1-benzylpiperidin-4-yl)ethyl]-1-[3-cyano-4- ...)
Show SMILES FC(F)(F)Oc1ccc(cc1C#N)N1CCC(CC1)C(=O)NCCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C28H33F3N4O2/c29-28(30,31)37-26-7-6-25(18-24(26)19-32)35-16-11-23(12-17-35)27(36)33-13-8-21-9-14-34(15-10-21)20-22-4-2-1-3-5-22/h1-7,18,21,23H,8-17,20H2,(H,33,36)
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM503143
PNG
((3R)-N-[2-(1-benzylpiperidin-4-yl)ethyl]-1-(5-cyan...)
Show SMILES C[C@H]1CN(CCC1C(=O)NCCC1CCN(Cc2ccccc2)CC1)c1ccc(cn1)C#N
Show InChI InChI=1S/C27H35N5O/c1-21-19-32(26-8-7-24(17-28)18-30-26)16-12-25(21)27(33)29-13-9-22-10-14-31(15-11-22)20-23-5-3-2-4-6-23/h2-8,18,21-22,25H,9-16,19-20H2,1H3,(H,29,33)/t21-,25?/m0/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM503188
PNG
(N-[2-(1-benzylpiperidin-4-yl)ethyl]-7-methyl-2-[3-...)
Show SMILES Cc1c(cnc2cc(nn12)-c1cccc(c1)C(F)(F)F)C(=O)NCCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C29H30F3N5O/c1-20-25(18-34-27-17-26(35-37(20)27)23-8-5-9-24(16-23)29(30,31)32)28(38)33-13-10-21-11-14-36(15-12-21)19-22-6-3-2-4-7-22/h2-9,16-18,21H,10-15,19H2,1H3,(H,33,38)
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM503190
PNG
(N-[2-(1-benzyl-4-hydroxypiperidin-4-yl)ethyl]-7-me...)
Show SMILES Cc1c(cnc2cc(nn12)-c1cccc(c1)C(F)(F)F)C(=O)NCCC1(O)CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C29H30F3N5O2/c1-20-24(18-34-26-17-25(35-37(20)26)22-8-5-9-23(16-22)29(30,31)32)27(38)33-13-10-28(39)11-14-36(15-12-28)19-21-6-3-2-4-7-21/h2-9,16-18,39H,10-15,19H2,1H3,(H,33,38)
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM502819
PNG
((2S,6R)-N-[2-(1-benzylpiperidin-4-yl)ethyl]-4-(5-c...)
Show SMILES C[C@H]1CN(C[C@@H](C)N1C(=O)NCCC1CCN(Cc2ccccc2)CC1)c1ncc(cn1)C#N
Show InChI InChI=1S/C26H35N7O/c1-20-17-32(25-29-15-24(14-27)16-30-25)18-21(2)33(20)26(34)28-11-8-22-9-12-31(13-10-22)19-23-6-4-3-5-7-23/h3-7,15-16,20-22H,8-13,17-19H2,1-2H3,(H,28,34)/t20-,21+
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM503245
PNG
((2R,6S)-N-[2-(1-benzylpiperidin-4-yl)ethyl]-4-(4-c...)
Show SMILES C[C@H]1CN(C[C@@H](C)N1C(=O)NCCC1CCN(Cc2ccccc2)CC1)c1ccc(cc1)C#N
Show InChI InChI=1S/C28H37N5O/c1-22-19-32(27-10-8-25(18-29)9-11-27)20-23(2)33(22)28(34)30-15-12-24-13-16-31(17-14-24)21-26-6-4-3-5-7-26/h3-11,22-24H,12-17,19-21H2,1-2H3,(H,30,34)/t22-,23+
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM503250
PNG
((2R,6S)-N-[2-(1-benzylpiperidin-4-yl)ethyl]-4-(3-c...)
Show SMILES C[C@H]1CN(C[C@@H](C)N1C(=O)NCCC1CCN(Cc2ccccc2)CC1)c1cc(F)c(F)c(Cl)c1
Show InChI InChI=1S/C27H35ClF2N4O/c1-19-16-33(23-14-24(28)26(30)25(29)15-23)17-20(2)34(19)27(35)31-11-8-21-9-12-32(13-10-21)18-22-6-4-3-5-7-22/h3-7,14-15,19-21H,8-13,16-18H2,1-2H3,(H,31,35)/t19-,20+
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM502838
PNG
((2R)-N-[2-(1-benzylpiperidin-4-yl)ethyl]-4-(5-brom...)
Show SMILES C[C@@H]1CN(CCN1C(=O)NCCC1CCN(Cc2ccccc2)CC1)c1ncc(Br)cn1
Show InChI InChI=1S/C24H33BrN6O/c1-19-17-30(23-27-15-22(25)16-28-23)13-14-31(19)24(32)26-10-7-20-8-11-29(12-9-20)18-21-5-3-2-4-6-21/h2-6,15-16,19-20H,7-14,17-18H2,1H3,(H,26,32)/t19-/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM502705
PNG
((2R)-N-[2-(1-benzylpiperidin-4-yl)ethyl]-2-methyl-...)
Show SMILES C[C@@H]1CN(CCN1C(=O)NCCC1CCN(Cc2ccccc2)CC1)c1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C26H34F3N5O/c1-20-18-33(24-8-7-23(17-31-24)26(27,28)29)15-16-34(20)25(35)30-12-9-21-10-13-32(14-11-21)19-22-5-3-2-4-6-22/h2-8,17,20-21H,9-16,18-19H2,1H3,(H,30,35)/t20-/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM502724
PNG
((2R)-N-[2-(1-benzylpiperidin-4-yl)ethyl]-2-methyl-...)
Show SMILES C[C@@H]1CN(CCN1C(=O)NCCC1CCN(Cc2ccccc2)CC1)c1cc(ccn1)C(F)(F)F
Show InChI InChI=1S/C26H34F3N5O/c1-20-18-33(24-17-23(8-12-30-24)26(27,28)29)15-16-34(20)25(35)31-11-7-21-9-13-32(14-10-21)19-22-5-3-2-4-6-22/h2-6,8,12,17,20-21H,7,9-11,13-16,18-19H2,1H3,(H,31,35)/t20-/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM502735
PNG
((2S)-N-[2-(1-benzylpiperidin-4-yl)ethyl]-4-[3-cyan...)
Show SMILES C[C@H]1CN(CCN1C(=O)NCCC1CCN(Cc2ccccc2)CC1)c1ccc(OC(F)(F)F)c(c1)C#N
Show InChI InChI=1S/C28H34F3N5O2/c1-21-19-35(25-7-8-26(24(17-25)18-32)38-28(29,30)31)15-16-36(21)27(37)33-12-9-22-10-13-34(14-11-22)20-23-5-3-2-4-6-23/h2-8,17,21-22H,9-16,19-20H2,1H3,(H,33,37)/t21-/m0/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM502788
PNG
(N-[2-(1-benzylpiperidin-4-yl)ethyl]-4-[5-(trifluor...)
Show SMILES FC(F)(F)c1ccc(nc1)N1CCN(CC1)C(=O)NCCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C25H32F3N5O/c26-25(27,28)22-6-7-23(30-18-22)32-14-16-33(17-15-32)24(34)29-11-8-20-9-12-31(13-10-20)19-21-4-2-1-3-5-21/h1-7,18,20H,8-17,19H2,(H,29,34)
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM502799
PNG
((2R)-N-[2-(1-benzylpiperidin-4-yl)ethyl]-2-methyl-...)
Show SMILES C[C@@H]1CN(CCN1C(=O)NCCC1CCN(Cc2ccccc2)CC1)c1nccc(n1)C(F)(F)F
Show InChI InChI=1S/C25H33F3N6O/c1-19-17-33(23-29-12-8-22(31-23)25(26,27)28)15-16-34(19)24(35)30-11-7-20-9-13-32(14-10-20)18-21-5-3-2-4-6-21/h2-6,8,12,19-20H,7,9-11,13-18H2,1H3,(H,30,35)/t19-/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM502835
PNG
((2R,6S)-4-[4-amino-5-(trifluoromethyl)pyrimidin-2-...)
Show SMILES C[C@H]1CN(C[C@@H](C)N1C(=O)NCCC1CCN(Cc2ccccc2)CC1)c1ncc(c(N)n1)C(F)(F)F
Show InChI InChI=1S/C26H36F3N7O/c1-18-15-35(24-32-14-22(23(30)33-24)26(27,28)29)16-19(2)36(18)25(37)31-11-8-20-9-12-34(13-10-20)17-21-6-4-3-5-7-21/h3-7,14,18-20H,8-13,15-17H2,1-2H3,(H,31,37)(H2,30,32,33)/t18-,19+
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM502844
PNG
((2R)-N-{2-[1-(1H-indol-5-ylmethyl)piperidin-4-yl]e...)
Show SMILES C[C@@H]1CN(CCN1C(=O)NCCC1CCN(Cc2ccc3[nH]ccc3c2)CC1)c1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C28H34F3N5O/c1-19-17-35(23-15-24(29)27(31)25(30)16-23)12-13-36(19)28(37)33-8-4-20-6-10-34(11-7-20)18-21-2-3-26-22(14-21)5-9-32-26/h2-3,5,9,14-16,19-20,32H,4,6-8,10-13,17-18H2,1H3,(H,33,37)/t19-/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM502699
PNG
((2R)-N-[2-(1-benzylpiperidin-4-yl)ethyl]-4-[3-fluo...)
Show SMILES C[C@@H]1CN(CCN1C(=O)NCCC1CCN(Cc2ccccc2)CC1)c1ncc(cc1F)C(F)(F)F
Show InChI InChI=1S/C26H33F4N5O/c1-19-17-34(24-23(27)15-22(16-32-24)26(28,29)30)13-14-35(19)25(36)31-10-7-20-8-11-33(12-9-20)18-21-5-3-2-4-6-21/h2-6,15-16,19-20H,7-14,17-18H2,1H3,(H,31,36)/t19-/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM502729
PNG
((3R)-N-[2-(1-benzylpiperidin-4-yl)ethyl]-3-methyl-...)
Show SMILES C[C@@H]1CN(CCN1c1cc(F)c(F)c(F)c1)C(=O)NCCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C26H33F3N4O/c1-19-17-32(13-14-33(19)22-15-23(27)25(29)24(28)16-22)26(34)30-10-7-20-8-11-31(12-9-20)18-21-5-3-2-4-6-21/h2-6,15-16,19-20H,7-14,17-18H2,1H3,(H,30,34)/t19-/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM502736
PNG
((3R)-N-[2-(1-benzylpiperidin-4-yl)ethyl]-4-[3-fluo...)
Show SMILES C[C@@H]1CN(CCN1c1ccc(OC(F)(F)F)c(F)c1)C(=O)NCCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C27H34F4N4O2/c1-20-18-34(15-16-35(20)23-7-8-25(24(28)17-23)37-27(29,30)31)26(36)32-12-9-21-10-13-33(14-11-21)19-22-5-3-2-4-6-22/h2-8,17,20-21H,9-16,18-19H2,1H3,(H,32,36)/t20-/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM502989
PNG
(N-[2-(1-benzylpiperidin-4-yl)ethyl]-3-(5-cyanopyri...)
Show SMILES O=C(NCCC1CCN(Cc2ccccc2)CC1)N1C2CCC1CN(C2)c1ncc(cn1)C#N
Show InChI InChI=1S/C26H33N7O/c27-14-22-15-29-25(30-16-22)32-18-23-6-7-24(19-32)33(23)26(34)28-11-8-20-9-12-31(13-10-20)17-21-4-2-1-3-5-21/h1-5,15-16,20,23-24H,6-13,17-19H2,(H,28,34)
PDB

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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM502764
PNG
((2S)-N-[2-(1-benzylpiperidin-4-yl)ethyl]-4-[3-fluo...)
Show SMILES C[C@H]1CN(CCN1C(=O)NCCC1CCN(Cc2ccccc2)CC1)c1ccc(OC(F)(F)F)c(F)c1
Show InChI InChI=1S/C27H34F4N4O2/c1-20-18-34(23-7-8-25(24(28)17-23)37-27(29,30)31)15-16-35(20)26(36)32-12-9-21-10-13-33(14-11-21)19-22-5-3-2-4-6-22/h2-8,17,20-21H,9-16,18-19H2,1H3,(H,32,36)/t20-/m0/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM502765
PNG
((2S,6R)-4-(4-amino-5-cyanopyrimidin-2-yl)-N-[2-(1-...)
Show SMILES C[C@H]1CN(C[C@@H](C)N1C(=O)NCCC1CCN(Cc2ccccc2)CC1)c1ncc(C#N)c(N)n1
Show InChI InChI=1S/C26H36N8O/c1-19-16-33(25-30-15-23(14-27)24(28)31-25)17-20(2)34(19)26(35)29-11-8-21-9-12-32(13-10-21)18-22-6-4-3-5-7-22/h3-7,15,19-21H,8-13,16-18H2,1-2H3,(H,29,35)(H2,28,30,31)/t19-,20+
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM502782
PNG
((2R)-N-[2-(1-benzylpiperidin-4-yl)ethyl]-4-[2-fluo...)
Show SMILES C[C@@H]1CN(CCN1C(=O)NCCC1CCN(Cc2ccccc2)CC1)c1ccc(cc1F)C(F)(F)F
Show InChI InChI=1S/C27H34F4N4O/c1-20-18-34(25-8-7-23(17-24(25)28)27(29,30)31)15-16-35(20)26(36)32-12-9-21-10-13-33(14-11-21)19-22-5-3-2-4-6-22/h2-8,17,20-21H,9-16,18-19H2,1H3,(H,32,36)/t20-/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM502792
PNG
((2R)-4-(4-amino-5-cyanopyrimidin-2-yl)-N-[2-(1-ben...)
Show SMILES C[C@@H]1CN(CCN1C(=O)NCCC1CCN(Cc2ccccc2)CC1)c1ncc(C#N)c(N)n1
Show InChI InChI=1S/C25H34N8O/c1-19-17-32(24-29-16-22(15-26)23(27)30-24)13-14-33(19)25(34)28-10-7-20-8-11-31(12-9-20)18-21-5-3-2-4-6-21/h2-6,16,19-20H,7-14,17-18H2,1H3,(H,28,34)(H2,27,29,30)/t19-/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM502796
PNG
((2R)-N-[2-(1-benzylpiperidin-4-yl)ethyl]-4-(4-chlo...)
Show SMILES C[C@@H]1CN(CCN1C(=O)NCCC1CCN(Cc2ccccc2)CC1)c1nc(Cl)cc(n1)C#N
Show InChI InChI=1S/C25H32ClN7O/c1-19-17-32(24-29-22(16-27)15-23(26)30-24)13-14-33(19)25(34)28-10-7-20-8-11-31(12-9-20)18-21-5-3-2-4-6-21/h2-6,15,19-20H,7-14,17-18H2,1H3,(H,28,34)/t19-/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM502819
PNG
((2S,6R)-N-[2-(1-benzylpiperidin-4-yl)ethyl]-4-(5-c...)
Show SMILES C[C@H]1CN(C[C@@H](C)N1C(=O)NCCC1CCN(Cc2ccccc2)CC1)c1ncc(cn1)C#N
Show InChI InChI=1S/C26H35N7O/c1-20-17-32(25-29-15-24(14-27)16-30-25)18-21(2)33(20)26(34)28-11-8-22-9-12-31(13-10-22)19-23-6-4-3-5-7-23/h3-7,15-16,20-22H,8-13,17-19H2,1-2H3,(H,28,34)/t20-,21+
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM502823
PNG
((2R)-N-[2-(1-benzylpiperidin-4-yl)ethyl]-4-[5-cyan...)
Show SMILES CNc1nc(ncc1C#N)N1CCN([C@H](C)C1)C(=O)NCCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C26H36N8O/c1-20-18-33(25-30-17-23(16-27)24(28-2)31-25)14-15-34(20)26(35)29-11-8-21-9-12-32(13-10-21)19-22-6-4-3-5-7-22/h3-7,17,20-21H,8-15,18-19H2,1-2H3,(H,29,35)(H,28,30,31)/t20-/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM502900
PNG
((2R,6S)-N-{2-[1-(1H-indol-5-ylmethyl)piperidin-4-y...)
Show SMILES C[C@H]1CN(C[C@@H](C)N1C(=O)NCCC1CCN(Cc2ccc3[nH]ccc3c2)CC1)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C28H36F3N7O/c1-19-16-37(24-14-34-26(35-15-24)28(29,30)31)17-20(2)38(19)27(39)33-9-5-21-7-11-36(12-8-21)18-22-3-4-25-23(13-22)6-10-32-25/h3-4,6,10,13-15,19-21,32H,5,7-9,11-12,16-18H2,1-2H3,(H,33,39)/t19-,20+
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM502994
PNG
((2R)-N-[(2S)-2-(1-benzylpiperidin-4-yl)-2-hydroxye...)
Show SMILES C[C@@H]1CN(CCN1C(=O)NC[C@@H](O)C1CCN(Cc2ccccc2)CC1)c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C27H34FN5O2/c1-20-18-32(25-14-22(16-29)13-24(28)15-25)11-12-33(20)27(35)30-17-26(34)23-7-9-31(10-8-23)19-21-5-3-2-4-6-21/h2-6,13-15,20,23,26,34H,7-12,17-19H2,1H3,(H,30,35)/t20-,26-/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM502998
PNG
(N-[2-(1-benzyl-4-hydroxypiperidin-4-yl)ethyl]-1-[3...)
Show SMILES OC1(CCNC(=O)C2CCN(CC2)c2ccc(OC(F)(F)F)c(F)c2)CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C27H33F4N3O3/c28-23-18-22(6-7-24(23)37-27(29,30)31)34-14-8-21(9-15-34)25(35)32-13-10-26(36)11-16-33(17-12-26)19-20-4-2-1-3-5-20/h1-7,18,21,36H,8-17,19H2,(H,32,35)
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM503052
PNG
(N-[2-(1-benzylpiperidin-4-yl)ethyl]-1-[3-chloro-5 ...)
Show SMILES FC(F)(F)c1cnc(N2CCC(CC2)C(=O)NCCC2CCN(Cc3ccccc3)CC2)c(Cl)c1
Show InChI InChI=1S/C26H32ClF3N4O/c27-23-16-22(26(28,29)30)17-32-24(23)34-14-9-21(10-15-34)25(35)31-11-6-19-7-12-33(13-8-19)18-20-4-2-1-3-5-20/h1-5,16-17,19,21H,6-15,18H2,(H,31,35)
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM502997
PNG
(N-[2-(1-benzylpiperidin-4-yl)-2-hydroxyethyl]-1-[4...)
Show SMILES OC(CNC(=O)C1CCN(CC1)c1ccc(OC(F)(F)F)cc1)C1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C27H34F3N3O3/c28-27(29,30)36-24-8-6-23(7-9-24)33-16-12-22(13-17-33)26(35)31-18-25(34)21-10-14-32(15-11-21)19-20-4-2-1-3-5-20/h1-9,21-22,25,34H,10-19H2,(H,31,35)
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM503073
PNG
(N-[2-(1-benzylpiperidin-4-yl)ethyl]-1-[4- (trifluo...)
Show SMILES FC(F)(F)c1ccc(cc1)N1CCC(CC1)C(=O)NCCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C27H34F3N3O/c28-27(29,30)24-6-8-25(9-7-24)33-18-13-23(14-19-33)26(34)31-15-10-21-11-16-32(17-12-21)20-22-4-2-1-3-5-22/h1-9,21,23H,10-20H2,(H,31,34)
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM503078
PNG
(N-[2-(1-benzylpiperidin-4-yl)ethyl]-1-(3-cyano-5- ...)
Show SMILES Fc1cc(cc(c1)N1CCC(CC1)C(=O)NCCC1CCN(Cc2ccccc2)CC1)C#N
Show InChI InChI=1S/C27H33FN4O/c28-25-16-23(19-29)17-26(18-25)32-14-9-24(10-15-32)27(33)30-11-6-21-7-12-31(13-8-21)20-22-4-2-1-3-5-22/h1-5,16-18,21,24H,6-15,20H2,(H,30,33)
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM503200
PNG
(N-[2-(1-benzylpiperidin-4-yl)ethyl]-2-(3,5-difluor...)
Show SMILES Cc1c(cnc2cc(nn12)-c1cc(F)cc(F)c1)C(=O)NCCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C28H29F2N5O/c1-19-25(17-32-27-16-26(33-35(19)27)22-13-23(29)15-24(30)14-22)28(36)31-10-7-20-8-11-34(12-9-20)18-21-5-3-2-4-6-21/h2-6,13-17,20H,7-12,18H2,1H3,(H,31,36)
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM503226
PNG
((3R)-N-[2-(1-benzylpiperidin-4-yl)ethyl]-1-(5-chlo...)
Show SMILES C[C@H]1CN(CCC1C(=O)NCCC1CCN(Cc2ccccc2)CC1)c1ncc(Cl)cn1
Show InChI InChI=1S/C25H34ClN5O/c1-19-17-31(25-28-15-22(26)16-29-25)14-10-23(19)24(32)27-11-7-20-8-12-30(13-9-20)18-21-5-3-2-4-6-21/h2-6,15-16,19-20,23H,7-14,17-18H2,1H3,(H,27,32)/t19-,23?/m0/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM503242
PNG
((2R)-4-[4-amino-5-(trifluoromethyl)pyrimidin-2-yl]...)
Show SMILES C[C@H]1CN(CCN1C(=O)NCCC1CCN(Cc2ccccc2)CC1)c1ncc(c(N)n1)C(F)(F)F
Show InChI InChI=1S/C25H34F3N7O/c1-18-16-34(23-31-15-21(22(29)32-23)25(26,27)28)13-14-35(18)24(36)30-10-7-19-8-11-33(12-9-19)17-20-5-3-2-4-6-20/h2-6,15,18-19H,7-14,16-17H2,1H3,(H,30,36)(H2,29,31,32)/t18-/m0/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM503248
PNG
((2R,6S)-N-[2-(1-benzylpiperidin-4-yl)ethyl]-4-(3,5...)
Show SMILES C[C@H]1CN(C[C@@H](C)N1C(=O)NCCC1CCN(Cc2ccccc2)CC1)c1ncc(F)cc1F
Show InChI InChI=1S/C26H35F2N5O/c1-19-16-32(25-24(28)14-23(27)15-30-25)17-20(2)33(19)26(34)29-11-8-21-9-12-31(13-10-21)18-22-6-4-3-5-7-22/h3-7,14-15,19-21H,8-13,16-18H2,1-2H3,(H,29,34)/t19-,20+
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM503253
PNG
((2R)-N-[2-(1-benzylpiperidin-4-yl)ethyl]-4-(4-cyan...)
Show SMILES C[C@@H]1CN(CCN1C(=O)NCCC1CCN(Cc2ccccc2)CC1)c1cc(F)c(cc1F)C#N
Show InChI InChI=1S/C27H33F2N5O/c1-20-18-33(26-16-24(28)23(17-30)15-25(26)29)13-14-34(20)27(35)31-10-7-21-8-11-32(12-9-21)19-22-5-3-2-4-6-22/h2-6,15-16,20-21H,7-14,18-19H2,1H3,(H,31,35)/t20-/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM503255
PNG
((2R)-N-[2-(1-benzylpiperidin-4-yl)ethyl]-4-(4-cyan...)
Show SMILES C[C@@H]1CN(CCN1C(=O)NCCC1CCN(Cc2ccccc2)CC1)c1cc(F)c(C#N)c(F)c1
Show InChI InChI=1S/C27H33F2N5O/c1-20-18-33(23-15-25(28)24(17-30)26(29)16-23)13-14-34(20)27(35)31-10-7-21-8-11-32(12-9-21)19-22-5-3-2-4-6-22/h2-6,15-16,20-21H,7-14,18-19H2,1H3,(H,31,35)/t20-/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM503264
PNG
((2R,6S)-N-[2-(1-benzylpiperidin-4-yl)ethyl]-2,6-di...)
Show SMILES C[C@H]1CN(C[C@@H](C)N1C(=O)NCCC1CCN(Cc2ccccc2)CC1)c1cnc(cn1)C(F)(F)F
Show InChI InChI=1S/C26H35F3N6O/c1-19-16-34(24-15-31-23(14-32-24)26(27,28)29)17-20(2)35(19)25(36)30-11-8-21-9-12-33(13-10-21)18-22-6-4-3-5-7-22/h3-7,14-15,19-21H,8-13,16-18H2,1-2H3,(H,30,36)/t19-,20+
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM503265
PNG
((2R,6S)-N-[2-(1-benzylpiperidin-4-yl)ethyl]-4-(3-c...)
Show SMILES COc1ccc(cc1C#N)N1C[C@H](C)N([C@H](C)C1)C(=O)NCCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C29H39N5O2/c1-22-19-33(27-9-10-28(36-3)26(17-27)18-30)20-23(2)34(22)29(35)31-14-11-24-12-15-32(16-13-24)21-25-7-5-4-6-8-25/h4-10,17,22-24H,11-16,19-21H2,1-3H3,(H,31,35)/t22-,23+
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM503272
PNG
((2R)-N-[2-(1-benzylpiperidin-4-yl)ethyl]-4-[4-cyan...)
Show SMILES C[C@@H]1CN(CCN1C(=O)NCCC1CCN(Cc2ccccc2)CC1)c1ccc(C#N)c(c1)C(F)(F)F
Show InChI InChI=1S/C28H34F3N5O/c1-21-19-35(25-8-7-24(18-32)26(17-25)28(29,30)31)15-16-36(21)27(37)33-12-9-22-10-13-34(14-11-22)20-23-5-3-2-4-6-23/h2-8,17,21-22H,9-16,19-20H2,1H3,(H,33,37)/t21-/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM503277
PNG
((2R,6R)-4-[4-amino-5-(trifluoromethyl)pyrimidin-2-...)
Show SMILES C[C@@H]1CN(C[C@@H](C)N1C(=O)NCCC1CCN(Cc2ccccc2)CC1)c1ncc(c(N)n1)C(F)(F)F
Show InChI InChI=1S/C26H36F3N7O/c1-18-15-35(24-32-14-22(23(30)33-24)26(27,28)29)16-19(2)36(18)25(37)31-11-8-20-9-12-34(13-10-20)17-21-6-4-3-5-7-21/h3-7,14,18-20H,8-13,15-17H2,1-2H3,(H,31,37)(H2,30,32,33)/t18-,19-/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM502998
PNG
(N-[2-(1-benzyl-4-hydroxypiperidin-4-yl)ethyl]-1-[3...)
Show SMILES OC1(CCNC(=O)C2CCN(CC2)c2ccc(OC(F)(F)F)c(F)c2)CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C27H33F4N3O3/c28-23-18-22(6-7-24(23)37-27(29,30)31)34-14-8-21(9-15-34)25(35)32-13-10-26(36)11-16-33(17-12-26)19-20-4-2-1-3-5-20/h1-7,18,21,36H,8-17,19H2,(H,32,35)
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM503076
PNG
((2R)-N-[2-(1-benzylpiperidin-4-yl)ethyl]-4-[2-fluo...)
Show SMILES C[C@@H]1CN(CCN1C(=O)NCCC1CCN(Cc2ccccc2)CC1)c1ccc(OC(F)(F)F)cc1F
Show InChI InChI=1S/C27H34F4N4O2/c1-20-18-34(25-8-7-23(17-24(25)28)37-27(29,30)31)15-16-35(20)26(36)32-12-9-21-10-13-33(14-11-21)19-22-5-3-2-4-6-22/h2-8,17,20-21H,9-16,18-19H2,1H3,(H,32,36)/t20-/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM503077
PNG
(N-[2-(1-benzylpiperidin-4-yl)ethyl]-1-[4-cyano-3- ...)
Show SMILES FC(F)(F)Oc1cc(ccc1C#N)N1CCC(CC1)C(=O)NCCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C28H33F3N4O2/c29-28(30,31)37-26-18-25(7-6-24(26)19-32)35-16-11-23(12-17-35)27(36)33-13-8-21-9-14-34(15-10-21)20-22-4-2-1-3-5-22/h1-7,18,21,23H,8-17,20H2,(H,33,36)
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM503083
PNG
(N-[2-(1-benzylpiperidin-4-yl)ethyl]-1-[3- (trifluo...)
Show SMILES FC(F)(F)Oc1cccc(c1)N1CCC(CC1)C(=O)NCCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C27H34F3N3O2/c28-27(29,30)35-25-8-4-7-24(19-25)33-17-12-23(13-18-33)26(34)31-14-9-21-10-15-32(16-11-21)20-22-5-2-1-3-6-22/h1-8,19,21,23H,9-18,20H2,(H,31,34)
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2 and M4


(Homo sapiens (Human))
BDBM503084
PNG
(N-[2-(1-benzyl-4-hydroxypiperidin-4-yl)ethyl]-1-[3...)
Show SMILES OC1(CCNC(=O)C2CCN(CC2)c2ccc(OC(F)(F)F)c(c2)C#N)CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C28H33F3N4O3/c29-28(30,31)38-25-7-6-24(18-23(25)19-32)35-14-8-22(9-15-35)26(36)33-13-10-27(37)11-16-34(17-12-27)20-21-4-2-1-3-5-21/h1-7,18,22,37H,8-17,20H2,(H,33,36)
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
Binding affinity (Ki) of compounds was measured by inhibition of radioligand binding to membranes from CHO cells expressing human M1, M2, M3, M4 and ...


US Patent US11033539 (2021)

More data for this
Ligand-Target Pair
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