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Patent code US11034670

Compile Data Set for Download or QSAR
Found 70 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503592
PNG
(6-[4-[3-(6-fluoro-4-oxo-3H-quinazolin-2-yl)propano...)
Show SMILES OCC1CN(CCN1C(=O)CCc1nc2ccc(F)cc2c(=O)[nH]1)c1ccc(cn1)C#N
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503591
PNG
(US11034670, Ex. 31)
Show SMILES OCC1CN(CCN1C(=O)CCc1nc2ccccc2c(=O)[nH]1)c1ccc(cn1)C#N
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503571
PNG
(US11034670, Ex. 11)
Show SMILES O=C(CCc1nc2ccccc2c(=O)[nH]1)N1CCN(CC1)c1ccc(cn1)C#N
Show InChI InChI=1S/C21H20N6O2/c22-13-15-5-7-19(23-14-15)26-9-11-27(12-10-26)20(28)8-6-18-24-17-4-2-1-3-16(17)21(29)25-18/h1-5,7,14H,6,8-12H2,(H,24,25,29)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503593
PNG
(6-[4-[3-(5-fluoro-4-oxo-3H-quinazolin-2-yl)propano...)
Show SMILES OCC1CN(CCN1C(=O)CCc1nc2cccc(F)c2c(=O)[nH]1)c1ccc(cn1)C#N
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503578
PNG
(6-[4-[3-(6-fluoro-4-oxo-3H-quinazolin-2-yl)propano...)
Show SMILES Fc1ccc2nc(CCC(=O)N3CCN(CC3)c3ccc(cn3)C#N)[nH]c(=O)c2c1
Show InChI InChI=1S/C21H19FN6O2/c22-15-2-3-17-16(11-15)21(30)26-18(25-17)4-6-20(29)28-9-7-27(8-10-28)19-5-1-14(12-23)13-24-19/h1-3,5,11,13H,4,6-10H2,(H,25,26,30)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503562
PNG
(US11034670, Ex. 2)
Show SMILES NC(=O)c1ccc(N2CCN(CC2)C(=O)CCc2nc3ccccc3c(=O)[nH]2)c(Cl)c1
Show InChI InChI=1S/C22H22ClN5O3/c23-16-13-14(21(24)30)5-6-18(16)27-9-11-28(12-10-27)20(29)8-7-19-25-17-4-2-1-3-15(17)22(31)26-19/h1-6,13H,7-12H2,(H2,24,30)(H,25,26,31)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503576
PNG
(US11034670, Ex. 16)
Show SMILES Cc1cccc2c1nc(CCC(=O)N1CCN(CC1)c1ccc(cn1)C#N)[nH]c2=O
Show InChI InChI=1S/C22H22N6O2/c1-15-3-2-4-17-21(15)25-18(26-22(17)30)6-8-20(29)28-11-9-27(10-12-28)19-7-5-16(13-23)14-24-19/h2-5,7,14H,6,8-12H2,1H3,(H,25,26,30)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503577
PNG
(6-[4-[3-(5-fluoro-4-oxo-3H-quinazolin-2-yl)propano...)
Show SMILES Fc1cccc2nc(CCC(=O)N3CCN(CC3)c3ccc(cn3)C#N)[nH]c(=O)c12
Show InChI InChI=1S/C21H19FN6O2/c22-15-2-1-3-16-20(15)21(30)26-17(25-16)5-7-19(29)28-10-8-27(9-11-28)18-6-4-14(12-23)13-24-18/h1-4,6,13H,5,7-11H2,(H,25,26,30)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503588
PNG
(US11034670, Ex. 28)
Show SMILES C[C@H]1CN(CCN1C(=O)CCc1nc2ccccc2c(=O)[nH]1)c1ccc(cn1)C#N
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503584
PNG
(US11034670, Ex. 24)
Show SMILES O=C(CCc1nc2ccsc2c(=O)[nH]1)N1CCN(CC1)c1ccc(cn1)C#N
Show InChI InChI=1S/C19H18N6O2S/c20-11-13-1-3-16(21-12-13)24-6-8-25(9-7-24)17(26)4-2-15-22-14-5-10-28-18(14)19(27)23-15/h1,3,5,10,12H,2,4,6-9H2,(H,22,23,27)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503604
PNG
(US11034670, Ex. 44)
Show SMILES C[C@H]1CN(CCN1C(=O)CCc1nc2ccc(F)c(F)c2c(=O)[nH]1)c1ccc(cn1)C#N
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503590
PNG
(US11034670, Ex. 30)
Show SMILES C[C@H]1CN(CCN1C(=O)CCc1nc2cccc(F)c2c(=O)[nH]1)c1ccc(cn1)C#N
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503589
PNG
(US11034670, Ex. 29)
Show SMILES C[C@H]1CN(CCN1C(=O)CCc1nc2ccc(F)cc2c(=O)[nH]1)c1ccc(cn1)C#N
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503580
PNG
(US11034670, Ex. 20)
Show SMILES Fc1cccc2c1nc(CCC(=O)N1CCN(CC1)c1ccc(cn1)C#N)[nH]c2=O
Show InChI InChI=1S/C21H19FN6O2/c22-16-3-1-2-15-20(16)25-17(26-21(15)30)5-7-19(29)28-10-8-27(9-11-28)18-6-4-14(12-23)13-24-18/h1-4,6,13H,5,7-11H2,(H,25,26,30)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503599
PNG
(US11034670, Ex. 39)
Show SMILES O=C(CCc1nc2ccccc2c(=O)[nH]1)N1CCN(CC1)c1cnc(cn1)C#N
Show InChI InChI=1S/C20H19N7O2/c21-11-14-12-23-18(13-22-14)26-7-9-27(10-8-26)19(28)6-5-17-24-16-4-2-1-3-15(16)20(29)25-17/h1-4,12-13H,5-10H2,(H,24,25,29)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503563
PNG
(US11034670, Ex. 3)
Show SMILES CNC(=O)c1ccc(N2CCN(CC2)C(=O)CCc2nc3ccccc3c(=O)[nH]2)c(Cl)c1
Show InChI InChI=1S/C23H24ClN5O3/c1-25-22(31)15-6-7-19(17(24)14-15)28-10-12-29(13-11-28)21(30)9-8-20-26-18-5-3-2-4-16(18)23(32)27-20/h2-7,14H,8-13H2,1H3,(H,25,31)(H,26,27,32)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503574
PNG
(US11034670, Ex. 14)
Show SMILES Cc1ccc2nc(CCC(=O)N3CCN(CC3)c3ccc(cn3)C#N)[nH]c(=O)c2c1
Show InChI InChI=1S/C22H22N6O2/c1-15-2-4-18-17(12-15)22(30)26-19(25-18)5-7-21(29)28-10-8-27(9-11-28)20-6-3-16(13-23)14-24-20/h2-4,6,12,14H,5,7-11H2,1H3,(H,25,26,30)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503572
PNG
(6-[4-[3-(4-oxo-3H-quinazolin-2-yl)propanoyl]pipera...)
Show SMILES NC(=O)c1ccc(nc1)N1CCN(CC1)C(=O)CCc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C21H22N6O3/c22-20(29)14-5-7-18(23-13-14)26-9-11-27(12-10-26)19(28)8-6-17-24-16-4-2-1-3-15(16)21(30)25-17/h1-5,7,13H,6,8-12H2,(H2,22,29)(H,24,25,30)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503564
PNG
(US11034670, Ex. 4)
Show SMILES Clc1cc(ccc1N1CCN(CC1)C(=O)CCc1nc2ccccc2c(=O)[nH]1)C(=O)NC1CC1
Show InChI InChI=1S/C25H26ClN5O3/c26-19-15-16(24(33)27-17-6-7-17)5-8-21(19)30-11-13-31(14-12-30)23(32)10-9-22-28-20-4-2-1-3-18(20)25(34)29-22/h1-5,8,15,17H,6-7,9-14H2,(H,27,33)(H,28,29,34)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503561
PNG
(US11034670, Ex. 1)
Show SMILES Clc1cc(ccc1N1CCN(CC1)C(=O)CCc1nc2c(Cl)cccc2c(=O)[nH]1)C(=O)NC1CC1
Show InChI InChI=1S/C25H25Cl2N5O3/c26-18-3-1-2-17-23(18)29-21(30-25(17)35)8-9-22(33)32-12-10-31(11-13-32)20-7-4-15(14-19(20)27)24(34)28-16-5-6-16/h1-4,7,14,16H,5-6,8-13H2,(H,28,34)(H,29,30,35)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503566
PNG
(US11034670, Ex. 6)
Show SMILES CC1(CC1)NC(=O)c1ccc(N2CCN(CC2)C(=O)CCc2nc(=O)c3ccccc3[nH]2)c(Cl)c1
Show InChI InChI=1S/C26H28ClN5O3/c1-26(10-11-26)30-24(34)17-6-7-21(19(27)16-17)31-12-14-32(15-13-31)23(33)9-8-22-28-20-5-3-2-4-18(20)25(35)29-22/h2-7,16H,8-15H2,1H3,(H,30,34)(H,28,29,35)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503608
PNG
(US11034670, Ex. 48)
Show SMILES CNC(=N)c1ccc(nc1)N1CCN(CC1)C(=O)CCc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C22H25N7O2/c1-24-21(23)15-6-8-19(25-14-15)28-10-12-29(13-11-28)20(30)9-7-18-26-17-5-3-2-4-16(17)22(31)27-18/h2-6,8,14H,7,9-13H2,1H3,(H2,23,24)(H,26,27,31)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503567
PNG
(US11034670, Ex. 7)
Show SMILES CC1(COC1)NC(=O)c1ccc(N2CCN(CC2)C(=O)CCc2nc(=O)c3ccccc3[nH]2)c(Cl)c1
Show InChI InChI=1S/C26H28ClN5O4/c1-26(15-36-16-26)30-24(34)17-6-7-21(19(27)14-17)31-10-12-32(13-11-31)23(33)9-8-22-28-20-5-3-2-4-18(20)25(35)29-22/h2-7,14H,8-13,15-16H2,1H3,(H,30,34)(H,28,29,35)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503595
PNG
(US11034670, Ex. 35)
Show SMILES Cc1ccc(nc1)N1CCN(CC1)C(=O)CCc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C21H23N5O2/c1-15-6-8-19(22-14-15)25-10-12-26(13-11-25)20(27)9-7-18-23-17-5-3-2-4-16(17)21(28)24-18/h2-6,8,14H,7,9-13H2,1H3,(H,23,24,28)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503583
PNG
(US11034670, Ex. 23)
Show SMILES O=C(CCc1nc2sccc2c(=O)[nH]1)N1CCN(CC1)c1ccc(cn1)C#N
Show InChI InChI=1S/C19H18N6O2S/c20-11-13-1-3-16(21-12-13)24-6-8-25(9-7-24)17(26)4-2-15-22-18(27)14-5-10-28-19(14)23-15/h1,3,5,10,12H,2,4,6-9H2,(H,22,23,27)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503609
PNG
(US11034670, Ex. 49)
Show SMILES O=C(CCc1nc2ccccc2c(=O)[nH]1)N1CCN(CC1)c1ccc(cn1)C1=NCCN1
Show InChI InChI=1S/C23H25N7O2/c31-21(8-6-19-27-18-4-2-1-3-17(18)23(32)28-19)30-13-11-29(12-14-30)20-7-5-16(15-26-20)22-24-9-10-25-22/h1-5,7,15H,6,8-14H2,(H,24,25)(H,27,28,32)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM503576
PNG
(US11034670, Ex. 16)
Show SMILES Cc1cccc2c1nc(CCC(=O)N1CCN(CC1)c1ccc(cn1)C#N)[nH]c2=O
Show InChI InChI=1S/C22H22N6O2/c1-15-3-2-4-17-21(15)25-18(26-22(17)30)6-8-20(29)28-11-9-27(10-12-28)19-7-5-16(13-23)14-24-19/h2-5,7,14H,6,8-12H2,1H3,(H,25,26,30)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503603
PNG
(US11034670, Ex. 43)
Show SMILES CC(CC(=O)N1CCN(CC1)c1ccc(cn1)C#N)c1nc2ccccc2c(=O)[nH]1
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM503591
PNG
(US11034670, Ex. 31)
Show SMILES OCC1CN(CCN1C(=O)CCc1nc2ccccc2c(=O)[nH]1)c1ccc(cn1)C#N
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503586
PNG
(US11034670, Ex. 26)
Show SMILES C[C@@H]1CN(CCN1c1ccc(cn1)C#N)C(=O)CCc1nc2ccccc2c(=O)[nH]1
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503565
PNG
(US11034670, Ex. 5)
Show SMILES Clc1cc(ccc1N1CCN(CC1)C(=O)CCc1nc(=O)c2ccccc2[nH]1)C(=O)NC1CCC1
Show InChI InChI=1S/C26H28ClN5O3/c27-20-16-17(25(34)28-18-4-3-5-18)8-9-22(20)31-12-14-32(15-13-31)24(33)11-10-23-29-21-7-2-1-6-19(21)26(35)30-23/h1-2,6-9,16,18H,3-5,10-15H2,(H,28,34)(H,29,30,35)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503600
PNG
(US11034670, Ex. 40)
Show SMILES O=C(CCc1nc2ccccc2c(=O)[nH]1)N1CCN(CC1)c1ncc(s1)C#N
Show InChI InChI=1S/C19H18N6O2S/c20-11-13-12-21-19(28-13)25-9-7-24(8-10-25)17(26)6-5-16-22-15-4-2-1-3-14(15)18(27)23-16/h1-4,12H,5-10H2,(H,22,23,27)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503594
PNG
(US11034670, Ex. 34)
Show SMILES O=C(CCc1nc2ccccc2c(=O)[nH]1)N1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C20H21N5O2/c26-19(25-13-11-24(12-14-25)18-7-3-4-10-21-18)9-8-17-22-16-6-2-1-5-15(16)20(27)23-17/h1-7,10H,8-9,11-14H2,(H,22,23,27)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503573
PNG
(US11034670, Ex. 13)
Show SMILES Cc1cccc2nc(CCC(=O)N3CCN(CC3)c3ccc(cn3)C#N)[nH]c(=O)c12
Show InChI InChI=1S/C22H22N6O2/c1-15-3-2-4-17-21(15)22(30)26-18(25-17)6-8-20(29)28-11-9-27(10-12-28)19-7-5-16(13-23)14-24-19/h2-5,7,14H,6,8-12H2,1H3,(H,25,26,30)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503602
PNG
(US11034670, Ex. 42)
Show SMILES O=C(CCc1nc2ncccc2c(=O)[nH]1)N1CCN(CC1)c1ccc(cn1)C#N
Show InChI InChI=1S/C20H19N7O2/c21-12-14-3-5-17(23-13-14)26-8-10-27(11-9-26)18(28)6-4-16-24-19-15(20(29)25-16)2-1-7-22-19/h1-3,5,7,13H,4,6,8-11H2,(H,22,24,25,29)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503612
PNG
(2-(3-(4-(4-fluorophenyl)piperazin-1-yl)-3-oxopropy...)
Show SMILES Fc1ccc(cc1)N1CCN(CC1)C(=O)CCc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C21H21FN4O2/c22-15-5-7-16(8-6-15)25-11-13-26(14-12-25)20(27)10-9-19-23-18-4-2-1-3-17(18)21(28)24-19/h1-8H,9-14H2,(H,23,24,28)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM503562
PNG
(US11034670, Ex. 2)
Show SMILES NC(=O)c1ccc(N2CCN(CC2)C(=O)CCc2nc3ccccc3c(=O)[nH]2)c(Cl)c1
Show InChI InChI=1S/C22H22ClN5O3/c23-16-13-14(21(24)30)5-6-18(16)27-9-11-28(12-10-27)20(29)8-7-19-25-17-4-2-1-3-15(17)22(31)26-19/h1-6,13H,7-12H2,(H2,24,30)(H,25,26,31)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503585
PNG
(US11034670, Ex. 25)
Show SMILES C[C@H]1CN(CCN1c1ccc(cn1)C#N)C(=O)CCc1nc2ccccc2c(=O)[nH]1
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503611
PNG
(2-(3-(4-(4-fluorophenyl)-3,6-dihydropyridin-1 (2H)...)
Show SMILES Fc1ccc(cc1)C1=CCN(CC1)C(=O)CCc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C22H20FN3O2/c23-17-7-5-15(6-8-17)16-11-13-26(14-12-16)21(27)10-9-20-24-19-4-2-1-3-18(19)22(28)25-20/h1-8,11H,9-10,12-14H2,(H,24,25,28)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503579
PNG
(US11034670, Ex. 19)
Show SMILES Fc1ccc2c(c1)nc(CCC(=O)N1CCN(CC1)c1ccc(cn1)C#N)[nH]c2=O
Show InChI InChI=1S/C21H19FN6O2/c22-15-2-3-16-17(11-15)25-18(26-21(16)30)4-6-20(29)28-9-7-27(8-10-28)19-5-1-14(12-23)13-24-19/h1-3,5,11,13H,4,6-10H2,(H,25,26,30)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503605
PNG
(US11034670, Ex. 45)
Show SMILES O=C(CCc1nc2ccccc2c(=O)[nH]1)N1CCN(CC1)c1ncc(cn1)C#N
Show InChI InChI=1S/C20H19N7O2/c21-11-14-12-22-20(23-13-14)27-9-7-26(8-10-27)18(28)6-5-17-24-16-4-2-1-3-15(16)19(29)25-17/h1-4,12-13H,5-10H2,(H,24,25,29)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503587
PNG
(US11034670, Ex. 27)
Show SMILES C[C@@H]1CN(CCN1C(=O)CCc1nc2ccccc2c(=O)[nH]1)c1ccc(cn1)C#N
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503601
PNG
(US11034670, Ex. 41)
Show SMILES O=C(CCc1nc2ccncc2c(=O)[nH]1)N1CCN(CC1)c1ccc(cn1)C#N
Show InChI InChI=1S/C20H19N7O2/c21-11-14-1-3-18(23-12-14)26-7-9-27(10-8-26)19(28)4-2-17-24-16-5-6-22-13-15(16)20(29)25-17/h1,3,5-6,12-13H,2,4,7-10H2,(H,24,25,29)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503581
PNG
(US11034670, Ex. 21)
Show SMILES O=C(CCc1nc2cccnc2c(=O)[nH]1)N1CCN(CC1)c1ccc(cn1)C#N
Show InChI InChI=1S/C20H19N7O2/c21-12-14-3-5-17(23-13-14)26-8-10-27(11-9-26)18(28)6-4-16-24-15-2-1-7-22-19(15)20(29)25-16/h1-3,5,7,13H,4,6,8-11H2,(H,24,25,29)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503596
PNG
(US11034670, Ex. 36)
Show SMILES Cc1cccnc1N1CCN(CC1)C(=O)CCc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C21H23N5O2/c1-15-5-4-10-22-20(15)26-13-11-25(12-14-26)19(27)9-8-18-23-17-7-3-2-6-16(17)21(28)24-18/h2-7,10H,8-9,11-14H2,1H3,(H,23,24,28)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503598
PNG
(US11034670, Ex. 38)
Show SMILES Cc1ccnc(c1)N1CCN(CC1)C(=O)CCc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C21H23N5O2/c1-15-8-9-22-19(14-15)25-10-12-26(13-11-25)20(27)7-6-18-23-17-5-3-2-4-16(17)21(28)24-18/h2-5,8-9,14H,6-7,10-13H2,1H3,(H,23,24,28)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503569
PNG
(US11034670, Ex. 9)
Show SMILES O=C(CCc1nc2ccccc2c(=O)[nH]1)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C21H22N4O2/c26-20(25-14-12-24(13-15-25)16-6-2-1-3-7-16)11-10-19-22-18-9-5-4-8-17(18)21(27)23-19/h1-9H,10-15H2,(H,22,23,27)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503570
PNG
(US11034670, Ex. 10)
Show SMILES Clc1ccccc1N1CCN(CC1)C(=O)CCc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C21H21ClN4O2/c22-16-6-2-4-8-18(16)25-11-13-26(14-12-25)20(27)10-9-19-23-17-7-3-1-5-15(17)21(28)24-19/h1-8H,9-14H2,(H,23,24,28)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM503561
PNG
(US11034670, Ex. 1)
Show SMILES Clc1cc(ccc1N1CCN(CC1)C(=O)CCc1nc2c(Cl)cccc2c(=O)[nH]1)C(=O)NC1CC1
Show InChI InChI=1S/C25H25Cl2N5O3/c26-18-3-1-2-17-23(18)29-21(30-25(17)35)8-9-22(33)32-12-10-31(11-13-32)20-7-4-15(14-19(20)27)24(34)28-16-5-6-16/h1-4,7,14,16H,5-6,8-13H2,(H,28,34)(H,29,30,35)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503613
PNG
(2-(3-(4-(4-fluorophenyl)-3,6-dihydropyridin-1 (2H)...)
Show SMILES Cn1ccc2c1nc(CCC(=O)N1CCC(=CC1)c1ccc(F)cc1)[nH]c2=O
Show InChI InChI=1S/C21H21FN4O2/c1-25-11-10-17-20(25)23-18(24-21(17)28)6-7-19(27)26-12-8-15(9-13-26)14-2-4-16(22)5-3-14/h2-5,8,10-11H,6-7,9,12-13H2,1H3,(H,23,24,28)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM503563
PNG
(US11034670, Ex. 3)
Show SMILES CNC(=O)c1ccc(N2CCN(CC2)C(=O)CCc2nc3ccccc3c(=O)[nH]2)c(Cl)c1
Show InChI InChI=1S/C23H24ClN5O3/c1-25-22(31)15-6-7-19(17(24)14-15)28-10-12-29(13-11-28)21(30)9-8-20-26-18-5-3-2-4-16(18)23(32)27-20/h2-7,14H,8-13H2,1H3,(H,25,31)(H,26,27,32)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503575
PNG
(US11034670, Ex. 15)
Show SMILES Cc1ccc2c(c1)nc(CCC(=O)N1CCN(CC1)c1ccc(cn1)C#N)[nH]c2=O
Show InChI InChI=1S/C22H22N6O2/c1-15-2-4-17-18(12-15)25-19(26-22(17)30)5-7-21(29)28-10-8-27(9-11-28)20-6-3-16(13-23)14-24-20/h2-4,6,12,14H,5,7-11H2,1H3,(H,25,26,30)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM503577
PNG
(6-[4-[3-(5-fluoro-4-oxo-3H-quinazolin-2-yl)propano...)
Show SMILES Fc1cccc2nc(CCC(=O)N3CCN(CC3)c3ccc(cn3)C#N)[nH]c(=O)c12
Show InChI InChI=1S/C21H19FN6O2/c22-15-2-1-3-16-20(15)21(30)26-17(25-16)5-7-19(29)28-10-8-27(9-11-28)18-6-4-14(12-23)13-24-18/h1-4,6,13H,5,7-11H2,(H,25,26,30)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM503578
PNG
(6-[4-[3-(6-fluoro-4-oxo-3H-quinazolin-2-yl)propano...)
Show SMILES Fc1ccc2nc(CCC(=O)N3CCN(CC3)c3ccc(cn3)C#N)[nH]c(=O)c2c1
Show InChI InChI=1S/C21H19FN6O2/c22-15-2-3-17-16(11-15)21(30)26-18(25-17)4-6-20(29)28-9-7-27(8-10-28)19-5-1-14(12-23)13-24-19/h1-3,5,11,13H,4,6-10H2,(H,25,26,30)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503610
PNG
(US11034670, Ex. 50)
Show SMILES Fc1ccc(cc1)C1=CCN(CC1)C(=O)CCc1nc2c(Cl)cccc2c(=O)[nH]1
Show InChI InChI=1S/C22H19ClFN3O2/c23-18-3-1-2-17-21(18)25-19(26-22(17)29)8-9-20(28)27-12-10-15(11-13-27)14-4-6-16(24)7-5-14/h1-7,10H,8-9,11-13H2,(H,25,26,29)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503606
PNG
(US11034670, Ex. 46)
Show SMILES CN\C(=C/C(=N)N1CCN(CC1)C(=O)CCc1nc2ccccc2c(=O)[nH]1)C#N
Show InChI InChI=1S/C20H23N7O2/c1-23-14(13-21)12-17(22)26-8-10-27(11-9-26)19(28)7-6-18-24-16-5-3-2-4-15(16)20(29)25-18/h2-5,12,22-23H,6-11H2,1H3,(H,24,25,29)/b14-12-,22-17?
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503568
PNG
(US11034670, Ex. 8)
Show SMILES O=C(CCc1nc2ccccc2c(=O)[nH]1)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C22H23N3O2/c26-21(25-14-12-17(13-15-25)16-6-2-1-3-7-16)11-10-20-23-19-9-5-4-8-18(19)22(27)24-20/h1-9,17H,10-15H2,(H,23,24,27)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM503571
PNG
(US11034670, Ex. 11)
Show SMILES O=C(CCc1nc2ccccc2c(=O)[nH]1)N1CCN(CC1)c1ccc(cn1)C#N
Show InChI InChI=1S/C21H20N6O2/c22-13-15-5-7-19(23-14-15)26-9-11-27(12-10-26)20(28)8-6-18-24-17-4-2-1-3-16(17)21(29)25-18/h1-5,7,14H,6,8-12H2,(H,24,25,29)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM503611
PNG
(2-(3-(4-(4-fluorophenyl)-3,6-dihydropyridin-1 (2H)...)
Show SMILES Fc1ccc(cc1)C1=CCN(CC1)C(=O)CCc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C22H20FN3O2/c23-17-7-5-15(6-8-17)16-11-13-26(14-12-16)21(27)10-9-20-24-19-4-2-1-3-18(19)22(28)25-20/h1-8,11H,9-10,12-14H2,(H,24,25,28)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503597
PNG
(US11034670, Ex. 37)
Show SMILES Cc1cccc(n1)N1CCN(CC1)C(=O)CCc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C21H23N5O2/c1-15-5-4-8-19(22-15)25-11-13-26(14-12-25)20(27)10-9-18-23-17-7-3-2-6-16(17)21(28)24-18/h2-8H,9-14H2,1H3,(H,23,24,28)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503582
PNG
(US11034670, Ex. 22)
Show SMILES O=C(CCc1nc2cnccc2c(=O)[nH]1)N1CCN(CC1)c1ccc(cn1)C#N
Show InChI InChI=1S/C20H19N7O2/c21-11-14-1-3-18(23-12-14)26-7-9-27(10-8-26)19(28)4-2-17-24-16-13-22-6-5-15(16)20(29)25-17/h1,3,5-6,12-13H,2,4,7-10H2,(H,24,25,29)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM503599
PNG
(US11034670, Ex. 39)
Show SMILES O=C(CCc1nc2ccccc2c(=O)[nH]1)N1CCN(CC1)c1cnc(cn1)C#N
Show InChI InChI=1S/C20H19N7O2/c21-11-14-12-23-18(13-22-14)26-7-9-27(10-8-26)19(28)6-5-17-24-16-4-2-1-3-15(16)20(29)25-17/h1-4,12-13H,5-10H2,(H,24,25,29)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM503589
PNG
(US11034670, Ex. 29)
Show SMILES C[C@H]1CN(CCN1C(=O)CCc1nc2ccc(F)cc2c(=O)[nH]1)c1ccc(cn1)C#N
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM503590
PNG
(US11034670, Ex. 30)
Show SMILES C[C@H]1CN(CCN1C(=O)CCc1nc2cccc(F)c2c(=O)[nH]1)c1ccc(cn1)C#N
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM503588
PNG
(US11034670, Ex. 28)
Show SMILES C[C@H]1CN(CCN1C(=O)CCc1nc2ccccc2c(=O)[nH]1)c1ccc(cn1)C#N
PDB

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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM503607
PNG
(US11034670, Ex. 47)
Show SMILES CN(C)C(=O)c1ccc(N2CCN(CC2)C(=O)CCc2nc3ccccc3c(=O)[nH]2)c(Cl)c1
Show InChI InChI=1S/C24H26ClN5O3/c1-28(2)24(33)16-7-8-20(18(25)15-16)29-11-13-30(14-12-29)22(31)10-9-21-26-19-6-4-3-5-17(19)23(32)27-21/h3-8,15H,9-14H2,1-2H3,(H,26,27,32)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM503612
PNG
(2-(3-(4-(4-fluorophenyl)piperazin-1-yl)-3-oxopropy...)
Show SMILES Fc1ccc(cc1)N1CCN(CC1)C(=O)CCc1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C21H21FN4O2/c22-15-5-7-16(8-6-15)25-11-13-26(14-12-25)20(27)10-9-19-23-18-4-2-1-3-17(18)21(28)24-19/h1-8H,9-14H2,(H,23,24,28)
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Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM503584
PNG
(US11034670, Ex. 24)
Show SMILES O=C(CCc1nc2ccsc2c(=O)[nH]1)N1CCN(CC1)c1ccc(cn1)C#N
Show InChI InChI=1S/C19H18N6O2S/c20-11-13-1-3-16(21-12-13)24-6-8-25(9-7-24)17(26)4-2-15-22-14-5-10-28-18(14)19(27)23-15/h1,3,5,10,12H,2,4,6-9H2,(H,22,23,27)
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n/an/a 1.59E+3n/an/an/an/an/an/a



Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM503603
PNG
(US11034670, Ex. 43)
Show SMILES CC(CC(=O)N1CCN(CC1)c1ccc(cn1)C#N)c1nc2ccccc2c(=O)[nH]1
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n/an/a 3.82E+3n/an/an/an/an/an/a



Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM503583
PNG
(US11034670, Ex. 23)
Show SMILES O=C(CCc1nc2sccc2c(=O)[nH]1)N1CCN(CC1)c1ccc(cn1)C#N
Show InChI InChI=1S/C19H18N6O2S/c20-11-13-1-3-16(21-12-13)24-6-8-25(9-7-24)17(26)4-2-15-22-18(27)14-5-10-28-19(14)23-15/h1,3,5,10,12H,2,4,6-9H2,(H,22,23,27)
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n/an/a 1.03E+4n/an/an/an/an/an/a



Mitobridge, Inc.

US Patent


Assay Description
The scintillation proximity assay (SPA) is designed to measure PARP activity using purified recombinant PARP-1 enzyme and is ideal for high throughpu...


US Patent US11034670 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%