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Patent code US11034671

Compile Data Set for Download or QSAR
Found 100 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503615
PNG
(US11034671, Example 2)
Show SMILES COc1ccc2OCCCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C20H21N5O3/c1-27-14-8-9-17-15(12-14)20(26)23-18-7-5-6-16(22-18)19-24-21-13-25(19)10-3-2-4-11-28-17/h5-9,12-13H,2-4,10-11H2,1H3,(H,22,23,26)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503618
PNG
(US11034671, Example 5)
Show SMILES COc1ccc2CCCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C20H21N5O2/c1-27-15-10-9-14-6-3-2-4-11-25-13-21-24-19(25)17-7-5-8-18(22-17)23-20(26)16(14)12-15/h5,7-10,12-13H,2-4,6,11H2,1H3,(H,22,23,26)
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n/an/an/a 750n/an/an/an/an/a



SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503620
PNG
(US11034671, Example 7)
Show SMILES COc1ccc2OCCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C19H19N5O3/c1-26-13-7-8-16-14(11-13)19(25)22-17-6-4-5-15(21-17)18-23-20-12-24(18)9-2-3-10-27-16/h4-8,11-12H,2-3,9-10H2,1H3,(H,21,22,25)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503625
PNG
(US11034671, Example 12)
Show SMILES Brc1ccc2OCCC\C=C/Cn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C20H18BrN5O2/c21-14-8-9-17-15(12-14)20(27)24-18-7-5-6-16(23-18)19-25-22-13-26(19)10-3-1-2-4-11-28-17/h1,3,5-9,12-13H,2,4,10-11H2,(H,23,24,27)/b3-1-
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503634
PNG
(US11034671, Example 21)
Show SMILES O=C1Nc2cccc(c2)-c2nncn2CCCOc2ccc(cc12)-c1ccc(nc1)C1CC1
Show InChI InChI=1S/C26H23N5O2/c32-26-22-14-18(20-7-9-23(27-15-20)17-5-6-17)8-10-24(22)33-12-2-11-31-16-28-30-25(31)19-3-1-4-21(13-19)29-26/h1,3-4,7-10,13-17H,2,5-6,11-12H2,(H,29,32)
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n/an/an/a 1.50E+3n/an/an/an/an/a



SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503643
PNG
(US11034671, Example 31)
Show SMILES O=C1Nc2cccc(n2)-c2nncn2CCCCOc2ccc(cc12)C#N
Show InChI InChI=1S/C19H16N6O2/c20-11-13-6-7-16-14(10-13)19(26)23-17-5-3-4-15(22-17)18-24-21-12-25(18)8-1-2-9-27-16/h3-7,10,12H,1-2,8-9H2,(H,22,23,26)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503645
PNG
(US11034671, Example 33)
Show SMILES Brc1ccc2OCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C17H14BrN5O2/c18-11-5-6-14-12(9-11)17(24)21-15-4-1-3-13(20-15)16-22-19-10-23(16)7-2-8-25-14/h1,3-6,9-10H,2,7-8H2,(H,20,21,24)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503649
PNG
(US11034671, Example 39)
Show SMILES Fc1ccc(cn1)-c1ccc2OCCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C23H19FN6O2/c24-20-9-7-16(13-25-20)15-6-8-19-17(12-15)23(31)28-21-5-3-4-18(27-21)22-29-26-14-30(22)10-1-2-11-32-19/h3-9,12-14H,1-2,10-11H2,(H,27,28,31)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503652
PNG
(US11034671, Example 42)
Show SMILES O=C1Nc2cccc(n2)-c2nncn2CCCCOc2ccc(cc12)-c1ccsc1
Show InChI InChI=1S/C22H19N5O2S/c28-22-17-12-15(16-8-11-30-13-16)6-7-19(17)29-10-2-1-9-27-14-23-26-21(27)18-4-3-5-20(24-18)25-22/h3-8,11-14H,1-2,9-10H2,(H,24,25,28)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503655
PNG
(US11034671, Example 45)
Show SMILES CC(C)N1[Na]=CC=C1c1ccc2OCCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C24H25N6O2.Na/c1-4-19(26-16(2)3)17-10-11-21-18(14-17)24(31)28-22-9-7-8-20(27-22)23-29-25-15-30(23)12-5-6-13-32-21;/h1,4,7-11,14-16H,5-6,12-13H2,2-3H3,(H,27,28,31);/q-1;+1/b19-4-;
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503664
PNG
(US11034671, Example 55)
Show SMILES Cn1ncc2cc(ccc12)-c1ccc2OCCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C26H23N7O2/c1-32-22-9-7-17(13-19(22)15-28-32)18-8-10-23-20(14-18)26(34)30-24-6-4-5-21(29-24)25-31-27-16-33(25)11-2-3-12-35-23/h4-10,13-16H,2-3,11-12H2,1H3,(H,29,30,34)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503667
PNG
(US11034671, Example 58)
Show SMILES O=C1Nc2cccc(n2)-c2nncn2CCCCOc2ccc(cc12)-c1ccc2nccn2c1
Show InChI InChI=1S/C25H21N7O2/c33-25-19-14-17(18-7-9-23-26-10-12-31(23)15-18)6-8-21(19)34-13-2-1-11-32-16-27-30-24(32)20-4-3-5-22(28-20)29-25/h3-10,12,14-16H,1-2,11,13H2,(H,28,29,33)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503694
PNG
(General Procedure for Synthesis of Compounds Examp...)
Show SMILES C[C@H]1CCCOc2ccc(cc2C(=O)Nc2cccc(n2)-c2nncn12)-c1ccc(C)nc1
Show InChI InChI=1S/C25H24N6O2/c1-16-8-9-19(14-26-16)18-10-11-22-20(13-18)25(32)29-23-7-3-6-21(28-23)24-30-27-15-31(24)17(2)5-4-12-33-22/h3,6-11,13-15,17H,4-5,12H2,1-2H3,(H,28,29,32)/t17-/m0/s1
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503686
PNG
(US11034671, Example 79 | US11034671, Example 90)
Show SMILES FC(F)c1ccc(cn1)-c1ccc2OCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C23H18F2N6O2/c24-21(25)17-7-5-15(12-26-17)14-6-8-19-16(11-14)23(32)29-20-4-1-3-18(28-20)22-30-27-13-31(22)9-2-10-33-19/h1,3-8,11-13,21H,2,9-10H2,(H,28,29,32)
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n/an/an/a 1.50E+3n/an/an/an/an/a



SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503703
PNG
(US11034671, Example 97)
Show SMILES Cc1ccc(cn1)-c1ccc2OCCC3C[C@H]3n3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C25H22N6O2/c1-15-5-6-18(13-26-15)16-7-8-22-19(11-16)25(32)29-23-4-2-3-20(28-23)24-30-27-14-31(24)21-12-17(21)9-10-33-22/h2-8,11,13-14,17,21H,9-10,12H2,1H3,(H,28,29,32)/t17?,21-/m1/s1
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503614
PNG
(US11034671, Example 1)
Show SMILES COc1ccc2OC\C=C\CCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C20H19N5O3/c1-27-14-8-9-17-15(12-14)20(26)23-18-7-5-6-16(22-18)19-24-21-13-25(19)10-3-2-4-11-28-17/h2,4-9,12-13H,3,10-11H2,1H3,(H,22,23,26)/b4-2+
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503621
PNG
(US11034671, Example 8)
Show SMILES O=C1Nc2cccc(n2)-c2nncn2CCCCCc2ccc(cc12)-c1ccc(nc1)C1CC1
Show InChI InChI=1S/C27H26N6O/c34-27-22-15-20(21-12-13-23(28-16-21)19-9-10-19)11-8-18(22)5-2-1-3-14-33-17-29-32-26(33)24-6-4-7-25(30-24)31-27/h4,6-8,11-13,15-17,19H,1-3,5,9-10,14H2,(H,30,31,34)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503627
PNG
(US11034671, Example 14)
Show SMILES O=C1Nc2cccc(n2)-c2nncn2C\C=C\CCOc2ccc(cc12)-c1ccc(nc1)C1CC1
Show InChI InChI=1S/C27H24N6O2/c34-27-21-15-19(20-9-11-22(28-16-20)18-7-8-18)10-12-24(21)35-14-3-1-2-13-33-17-29-32-26(33)23-5-4-6-25(30-23)31-27/h1-2,4-6,9-12,15-18H,3,7-8,13-14H2,(H,30,31,34)/b2-1+
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503635
PNG
(US11034671, Example 22)
Show SMILES O=C1Nc2cccc(n2)-c2nncn2CCCCOc2ccc(cc12)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C24H23N7O2/c32-24-18-12-17(31-13-20(25-14-31)16-6-7-16)8-9-21(18)33-11-2-1-10-30-15-26-29-23(30)19-4-3-5-22(27-19)28-24/h3-5,8-9,12-16H,1-2,6-7,10-11H2,(H,27,28,32)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503640
PNG
(US11034671, Example 28)
Show SMILES Fc1cc2OCCCCn3cnnc3-c3cccc(NC(=O)c2cc1Br)n3
Show InChI InChI=1S/C18H15BrFN5O2/c19-12-8-11-15(9-13(12)20)27-7-2-1-6-25-10-21-24-17(25)14-4-3-5-16(22-14)23-18(11)26/h3-5,8-10H,1-2,6-7H2,(H,22,23,26)
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n/an/an/a 750n/an/an/an/an/a



SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503642
PNG
(US11034671, Example 30)
Show SMILES CC1(C)Cc2cc3OCCCCn4cnnc4-c4cccc(NC(=O)c3cc2O1)n4
Show InChI InChI=1S/C22H23N5O3/c1-22(2)12-14-10-18-15(11-17(14)30-22)21(28)25-19-7-5-6-16(24-19)20-26-23-13-27(20)8-3-4-9-29-18/h5-7,10-11,13H,3-4,8-9,12H2,1-2H3,(H,24,25,28)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503644
PNG
(US11034671, Example 32)
Show SMILES FC(F)(F)c1ccc2OCCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C19H16F3N5O2/c20-19(21,22)12-6-7-15-13(10-12)18(28)25-16-5-3-4-14(24-16)17-26-23-11-27(17)8-1-2-9-29-15/h3-7,10-11H,1-2,8-9H2,(H,24,25,28)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503657
PNG
(US11034671, Example 47)
Show SMILES CCc1ccc(cn1)-c1ccc2OCCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C25H24N6O2/c1-2-19-10-8-18(15-26-19)17-9-11-22-20(14-17)25(32)29-23-7-5-6-21(28-23)24-30-27-16-31(24)12-3-4-13-33-22/h5-11,14-16H,2-4,12-13H2,1H3,(H,28,29,32)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503674
PNG
(US11034671, Example 66)
Show SMILES O=C1Nc2cccc(n2)-c2nncn2CCCOc2ccc(cc12)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C23H21N7O2/c31-23-17-11-16(30-12-19(24-13-30)15-5-6-15)7-8-20(17)32-10-2-9-29-14-25-28-22(29)18-3-1-4-21(26-18)27-23/h1,3-4,7-8,11-15H,2,5-6,9-10H2,(H,26,27,31)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503677
PNG
(US11034671, Example 69)
Show SMILES Cc1ccc(cn1)-c1ccc2OCC3C[C@@H](C3)n3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C25H22N6O2/c1-15-5-6-18(12-26-15)17-7-8-22-20(11-17)25(32)29-23-4-2-3-21(28-23)24-30-27-14-31(24)19-9-16(10-19)13-33-22/h2-8,11-12,14,16,19H,9-10,13H2,1H3,(H,28,29,32)/t16?,19-
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503678
PNG
(US11034671, Example 70)
Show SMILES Cc1ccc(cn1)-c1ccc2COCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C24H22N6O2/c1-16-6-7-18(13-25-16)17-8-9-19-14-32-11-3-10-30-15-26-29-23(30)21-4-2-5-22(27-21)28-24(31)20(19)12-17/h2,4-9,12-13,15H,3,10-11,14H2,1H3,(H,27,28,31)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503691
PNG
(US11034671, Example 84)
Show SMILES FC(F)c1ccc(cn1)-c1ccc2OC3CC[C@@H](CC3)n3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C26H22F2N6O2/c27-24(28)20-10-4-16(13-29-20)15-5-11-22-19(12-15)26(35)32-23-3-1-2-21(31-23)25-33-30-14-34(25)17-6-8-18(36-22)9-7-17/h1-5,10-14,17-18,24H,6-9H2,(H,31,32,35)/t17-,18?
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503629
PNG
(US11034671, Example 16)
Show SMILES Brc1ccc2OC\C=C/Cn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C18H14BrN5O2/c19-12-6-7-15-13(10-12)18(25)22-16-5-3-4-14(21-16)17-23-20-11-24(17)8-1-2-9-26-15/h1-7,10-11H,8-9H2,(H,21,22,25)/b2-1-
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503638
PNG
(US11034671, Example 25)
Show SMILES Fc1cc2OCCCCn3cnnc3-c3cccc(NC(=O)c2cc1F)n3
Show InChI InChI=1S/C18H15F2N5O2/c19-12-8-11-15(9-13(12)20)27-7-2-1-6-25-10-21-24-17(25)14-4-3-5-16(22-14)23-18(11)26/h3-5,8-10H,1-2,6-7H2,(H,22,23,26)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503651
PNG
(US11034671, Example 41)
Show SMILES Clc1ccc2OCCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C18H16ClN5O2/c19-12-6-7-15-13(10-12)18(25)22-16-5-3-4-14(21-16)17-23-20-11-24(17)8-1-2-9-26-15/h3-7,10-11H,1-2,8-9H2,(H,21,22,25)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503661
PNG
(US11034671, Example 52)
Show SMILES FC(F)c1ccc(cn1)-c1ccc2OCCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C24H20F2N6O2/c25-22(26)18-8-6-16(13-27-18)15-7-9-20-17(12-15)24(33)30-21-5-3-4-19(29-21)23-31-28-14-32(23)10-1-2-11-34-20/h3-9,12-14,22H,1-2,10-11H2,(H,29,30,33)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503662
PNG
(US11034671, Example 53)
Show SMILES CC(C)(O)c1ccc2c(OCCCCn3cnnc3-c3cccc(NC2=O)n3)c1
Show InChI InChI=1S/C21H23N5O3/c1-21(2,28)14-8-9-15-17(12-14)29-11-4-3-10-26-13-22-25-19(26)16-6-5-7-18(23-16)24-20(15)27/h5-9,12-13,28H,3-4,10-11H2,1-2H3,(H,23,24,27)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503663
PNG
(US11034671, Example 54)
Show SMILES Clc1ccc(cn1)-c1ccc2OCCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C23H19ClN6O2/c24-20-9-7-16(13-25-20)15-6-8-19-17(12-15)23(31)28-21-5-3-4-18(27-21)22-29-26-14-30(22)10-1-2-11-32-19/h3-9,12-14H,1-2,10-11H2,(H,27,28,31)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503665
PNG
(US11034671, Example 56)
Show SMILES CC1CCCOc2ccc(cc2C(=O)Nc2cccc(n2)-c2nncn12)-c1ccc(C)nc1
Show InChI InChI=1S/C25H24N6O2/c1-16-8-9-19(14-26-16)18-10-11-22-20(13-18)25(32)29-23-7-3-6-21(28-23)24-30-27-15-31(24)17(2)5-4-12-33-22/h3,6-11,13-15,17H,4-5,12H2,1-2H3,(H,28,29,32)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503666
PNG
(US11034671, Example 57)
Show SMILES O=C1Nc2cccc(n2)-c2nncn2CCCOc2ccc(cc12)-c1ccccc1
Show InChI InChI=1S/C23H19N5O2/c29-23-18-14-17(16-6-2-1-3-7-16)10-11-20(18)30-13-5-12-28-15-24-27-22(28)19-8-4-9-21(25-19)26-23/h1-4,6-11,14-15H,5,12-13H2,(H,25,26,29)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503680
PNG
(US11034671, Example 72)
Show SMILES Cc1ccc(cn1)-c1ccc2OCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C22H18N6O2/c1-14-5-6-16(12-23-14)15-7-8-19-17(11-15)22(29)26-20-4-2-3-18(25-20)21-27-24-13-28(21)9-10-30-19/h2-8,11-13H,9-10H2,1H3,(H,25,26,29)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503692
PNG
(US11034671, Example 86)
Show SMILES FC(F)c1ccc(cn1)-c1ccc2OC3CC[C@@H](C3)n3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C25H20F2N6O2/c26-23(27)19-8-4-15(12-28-19)14-5-9-21-18(10-14)25(34)31-22-3-1-2-20(30-22)24-32-29-13-33(24)16-6-7-17(11-16)35-21/h1-5,8-10,12-13,16-17,23H,6-7,11H2,(H,30,31,34)/t16-,17?/m0/s1
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503702
PNG
(US11034671, Example 96)
Show SMILES O=C1Nc2cccc(n2)-c2nncn2CCCCOc2cc(ccc12)C#N
Show InChI InChI=1S/C19H16N6O2/c20-11-13-6-7-14-16(10-13)27-9-2-1-8-25-12-21-24-18(25)15-4-3-5-17(22-15)23-19(14)26/h3-7,10,12H,1-2,8-9H2,(H,22,23,26)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503619
PNG
(US11034671, Example 6)
Show SMILES COc1ccc2OC\C=C/Cn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C19H17N5O3/c1-26-13-7-8-16-14(11-13)19(25)22-17-6-4-5-15(21-17)18-23-20-12-24(18)9-2-3-10-27-16/h2-8,11-12H,9-10H2,1H3,(H,21,22,25)/b3-2-
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503624
PNG
(US11034671, Example 11)
Show SMILES COc1ccc2OCCCCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C21H23N5O3/c1-28-15-9-10-18-16(13-15)21(27)24-19-8-6-7-17(23-19)20-25-22-14-26(20)11-4-2-3-5-12-29-18/h6-10,13-14H,2-5,11-12H2,1H3,(H,23,24,27)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503632
PNG
(US11034671, Example 19)
Show SMILES O=C1Nc2cccc(n2)-c2nncn2CCCCCOc2ccc(cc12)-c1ccc(nc1)C1CC1
Show InChI InChI=1S/C27H26N6O2/c34-27-21-15-19(20-9-11-22(28-16-20)18-7-8-18)10-12-24(21)35-14-3-1-2-13-33-17-29-32-26(33)23-5-4-6-25(30-23)31-27/h4-6,9-12,15-18H,1-3,7-8,13-14H2,(H,30,31,34)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503637
PNG
(US11034671, Example 24)
Show SMILES Cc1ccc(cn1)-c1ccc2OCCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C24H22N6O2/c1-16-7-8-18(14-25-16)17-9-10-21-19(13-17)24(31)28-22-6-4-5-20(27-22)23-29-26-15-30(23)11-2-3-12-32-21/h4-10,13-15H,2-3,11-12H2,1H3,(H,27,28,31)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503639
PNG
(US11034671, Example 26)
Show SMILES Cc1c(F)c(F)cc2OCCCCn3cnnc3-c3cccc(NC(=O)c12)n3
Show InChI InChI=1S/C19H17F2N5O2/c1-11-16-14(9-12(20)17(11)21)28-8-3-2-7-26-10-22-25-18(26)13-5-4-6-15(23-13)24-19(16)27/h4-6,9-10H,2-3,7-8H2,1H3,(H,23,24,27)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503647
PNG
(US11034671, Example 37)
Show SMILES O=C1Nc2cccc(n2)-c2nncn2CCCOc2ccc(cc12)-c1ccc(nc1)C1CC1
Show InChI InChI=1S/C25H22N6O2/c32-25-19-13-17(18-7-9-20(26-14-18)16-5-6-16)8-10-22(19)33-12-2-11-31-15-27-30-24(31)21-3-1-4-23(28-21)29-25/h1,3-4,7-10,13-16H,2,5-6,11-12H2,(H,28,29,32)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503650
PNG
(US11034671, Example 40)
Show SMILES FC(F)(F)c1ccc(cn1)-c1ccc2OCCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C24H19F3N6O2/c25-24(26,27)20-9-7-16(13-28-20)15-6-8-19-17(12-15)23(34)31-21-5-3-4-18(30-21)22-32-29-14-33(22)10-1-2-11-35-19/h3-9,12-14H,1-2,10-11H2,(H,30,31,34)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503656
PNG
(US11034671, Example 46)
Show SMILES O=C1Nc2cccc(n2)-c2nncn2CCCCOc2ccc(cc12)C1CC1
Show InChI InChI=1S/C21H21N5O2/c27-21-16-12-15(14-6-7-14)8-9-18(16)28-11-2-1-10-26-13-22-25-20(26)17-4-3-5-19(23-17)24-21/h3-5,8-9,12-14H,1-2,6-7,10-11H2,(H,23,24,27)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503672
PNG
(US11034671, Example 64)
Show SMILES Cc1ccc(cn1)-c1cc2c(OCCCCn3cnnc3-c3cccc(NC2=O)n3)cc1F
Show InChI InChI=1S/C24H21FN6O2/c1-15-7-8-16(13-26-15)17-11-18-21(12-19(17)25)33-10-3-2-9-31-14-27-30-23(31)20-5-4-6-22(28-20)29-24(18)32/h4-8,11-14H,2-3,9-10H2,1H3,(H,28,29,32)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503675
PNG
(US11034671, Example 67)
Show SMILES CC1CCOc2ccc(cc2C(=O)Nc2cccc(n2)-c2nncn12)-c1ccc(C)nc1
Show InChI InChI=1S/C24H22N6O2/c1-15-6-7-18(13-25-15)17-8-9-21-19(12-17)24(31)28-22-5-3-4-20(27-22)23-29-26-14-30(23)16(2)10-11-32-21/h3-9,12-14,16H,10-11H2,1-2H3,(H,27,28,31)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503697
PNG
(US11034671, Example 91)
Show SMILES Cc1ccc(cn1)-c1ccc2SCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C23H20N6OS/c1-15-6-7-17(13-24-15)16-8-9-20-18(12-16)23(30)27-21-5-2-4-19(26-21)22-28-25-14-29(22)10-3-11-31-20/h2,4-9,12-14H,3,10-11H2,1H3,(H,26,27,30)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503698
PNG
(US11034671, Example 92)
Show SMILES CCc1ccc(cn1)-c1ccc2SCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C24H22N6OS/c1-2-18-9-7-17(14-25-18)16-8-10-21-19(13-16)24(31)28-22-6-3-5-20(27-22)23-29-26-15-30(23)11-4-12-32-21/h3,5-10,13-15H,2,4,11-12H2,1H3,(H,27,28,31)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503699
PNG
(US11034671, Example 93)
Show SMILES FC(F)c1ccc(cn1)-c1ccc2OC3CC(C3)n3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C24H18F2N6O2/c25-22(26)18-6-4-14(11-27-18)13-5-7-20-17(8-13)24(33)30-21-3-1-2-19(29-21)23-31-28-12-32(23)15-9-16(10-15)34-20/h1-8,11-12,15-16,22H,9-10H2,(H,29,30,33)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503706
PNG
(US11034671, Example 100)
Show SMILES FCc1ccc(cn1)-c1ccc2COCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C24H21FN6O2/c25-12-19-8-7-17(13-26-19)16-5-6-18-14-33-10-2-9-31-15-27-30-23(31)21-3-1-4-22(28-21)29-24(32)20(18)11-16/h1,3-8,11,13,15H,2,9-10,12,14H2,(H,28,29,32)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503711
PNG
(US11034671, Example 105)
Show SMILES FCCc1ccc(cn1)-c1ccc2OCCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C25H23FN6O2/c26-11-10-19-8-6-18(15-27-19)17-7-9-22-20(14-17)25(33)30-23-5-3-4-21(29-23)24-31-28-16-32(24)12-1-2-13-34-22/h3-9,14-16H,1-2,10-13H2,(H,29,30,33)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503617
PNG
(US11034671, Example 4)
Show SMILES COc1ccc2C\C=C\CCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C20H19N5O2/c1-27-15-10-9-14-6-3-2-4-11-25-13-21-24-19(25)17-7-5-8-18(22-17)23-20(26)16(14)12-15/h2-3,5,7-10,12-13H,4,6,11H2,1H3,(H,22,23,26)/b3-2+
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503626
PNG
(US11034671, Example 13)
Show SMILES O=C1Nc2cccc(n2)-c2nncn2C\C=C/CCCOc2ccc(cc12)-c1ccc(nc1)C1CC1
Show InChI InChI=1S/C28H26N6O2/c35-28-22-16-20(21-10-12-23(29-17-21)19-8-9-19)11-13-25(22)36-15-4-2-1-3-14-34-18-30-33-27(34)24-6-5-7-26(31-24)32-28/h1,3,5-7,10-13,16-19H,2,4,8-9,14-15H2,(H,31,32,35)/b3-1-
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503633
PNG
(US11034671, Example 20)
Show SMILES O=C1Nc2cccc(n2)-c2nncn2CCCCOc2ccc(OC3CCOC3)cc12
Show InChI InChI=1S/C22H23N5O4/c28-22-17-12-15(31-16-8-11-29-13-16)6-7-19(17)30-10-2-1-9-27-14-23-26-21(27)18-4-3-5-20(24-18)25-22/h3-7,12,14,16H,1-2,8-11,13H2,(H,24,25,28)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503636
PNG
(US11034671, Example 23)
Show SMILES O=C1Nc2cccc(n2)-c2nncn2CCCCOc2ccc(cc12)-c1ccc(nc1)C1CC1
Show InChI InChI=1S/C26H24N6O2/c33-26-20-14-18(19-8-10-21(27-15-19)17-6-7-17)9-11-23(20)34-13-2-1-12-32-16-28-31-25(32)22-4-3-5-24(29-22)30-26/h3-5,8-11,14-17H,1-2,6-7,12-13H2,(H,29,30,33)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503669
PNG
(US11034671, Example 60)
Show SMILES Cc1ccc(cn1)-c1ccc2OCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C23H20N6O2/c1-15-6-7-17(13-24-15)16-8-9-20-18(12-16)23(30)27-21-5-2-4-19(26-21)22-28-25-14-29(22)10-3-11-31-20/h2,4-9,12-14H,3,10-11H2,1H3,(H,26,27,30)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503681
PNG
(US11034671, Example 73)
Show SMILES Cc1ncc(cn1)-c1ccc2OCCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C23H21N7O2/c1-15-24-12-17(13-25-15)16-7-8-20-18(11-16)23(31)28-21-6-4-5-19(27-21)22-29-26-14-30(22)9-2-3-10-32-20/h4-8,11-14H,2-3,9-10H2,1H3,(H,27,28,31)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503684
PNG
(US11034671, Example 77)
Show SMILES Cc1ccc(cn1)-c1ccc2OCC3C[C@@H]3Cn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C25H22N6O2/c1-15-5-6-17(11-26-15)16-7-8-22-20(10-16)25(32)29-23-4-2-3-21(28-23)24-30-27-14-31(24)12-18-9-19(18)13-33-22/h2-8,10-11,14,18-19H,9,12-13H2,1H3,(H,28,29,32)/t18-,19?/m1/s1
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503693
PNG
(US11034671, Example 87)
Show SMILES FCc1ccc(cn1)-c1ccc2OCCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C24H21FN6O2/c25-13-18-8-6-17(14-26-18)16-7-9-21-19(12-16)24(32)29-22-5-3-4-20(28-22)23-30-27-15-31(23)10-1-2-11-33-21/h3-9,12,14-15H,1-2,10-11,13H2,(H,28,29,32)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503700
PNG
(US11034671, Example 94)
Show SMILES COc1ccc2CC=CCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C19H17N5O2/c1-26-14-9-8-13-5-2-3-10-24-12-20-23-18(24)16-6-4-7-17(21-16)22-19(25)15(13)11-14/h2-4,6-9,11-12H,5,10H2,1H3,(H,21,22,25)/b3-2+
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n/an/an/a 1.50E+3n/an/an/an/an/a



SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503623
PNG
(US11034671, Example 10)
Show SMILES Brc1ccc2OCCC=CCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C19H16BrN5O2/c20-13-7-8-16-14(11-13)19(26)23-17-6-4-5-15(22-17)18-24-21-12-25(18)9-2-1-3-10-27-16/h1-2,4-8,11-12H,3,9-10H2,(H,22,23,26)/b2-1+
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503631
PNG
(US11034671, Example 18)
Show SMILES O=C1Nc2cccc(n2)-c2nncn2C\C=C\COc2ccc(OCc3ccccc3)cc12
Show InChI InChI=1S/C25H21N5O3/c31-25-20-15-19(33-16-18-7-2-1-3-8-18)11-12-22(20)32-14-5-4-13-30-17-26-29-24(30)21-9-6-10-23(27-21)28-25/h1-12,15,17H,13-14,16H2,(H,27,28,31)/b5-4+
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503641
PNG
(US11034671, Example 29)
Show SMILES COc1cc2OCCCCn3cnnc3-c3cccc(NC(=O)c2cc1OC)n3
Show InChI InChI=1S/C20H21N5O4/c1-27-16-10-13-15(11-17(16)28-2)29-9-4-3-8-25-12-21-24-19(25)14-6-5-7-18(22-14)23-20(13)26/h5-7,10-12H,3-4,8-9H2,1-2H3,(H,22,23,26)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM50505947
PNG
(CHEMBL4469413 | US11034671, Example 35)
Show SMILES Fc1ccc2OCCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C18H16FN5O2/c19-12-6-7-15-13(10-12)18(25)22-16-5-3-4-14(21-16)17-23-20-11-24(17)8-1-2-9-26-15/h3-7,10-11H,1-2,8-9H2,(H,21,22,25)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503685
PNG
(US11034671, Example 78)
Show SMILES CC(F)(F)c1ccc(cn1)-c1ccc2OCCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C25H22F2N6O2/c1-25(26,27)21-10-8-17(14-28-21)16-7-9-20-18(13-16)24(34)31-22-6-4-5-19(30-22)23-32-29-15-33(23)11-2-3-12-35-20/h4-10,13-15H,2-3,11-12H2,1H3,(H,30,31,34)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503686
PNG
(US11034671, Example 79 | US11034671, Example 90)
Show SMILES FC(F)c1ccc(cn1)-c1ccc2OCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C23H18F2N6O2/c24-21(25)17-7-5-15(12-26-17)14-6-8-19-16(11-14)23(32)29-20-4-1-3-18(28-20)22-30-27-13-31(22)9-2-10-33-19/h1,3-8,11-13,21H,2,9-10H2,(H,28,29,32)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503688
PNG
(US11034671, Example 81)
Show SMILES Cc1ccc(cn1)-c1ccc2OCC3C[C@H]3Cn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C25H22N6O2/c1-15-5-6-17(11-26-15)16-7-8-22-20(10-16)25(32)29-23-4-2-3-21(28-23)24-30-27-14-31(24)12-18-9-19(18)13-33-22/h2-8,10-11,14,18-19H,9,12-13H2,1H3,(H,28,29,32)/t18-,19?/m0/s1
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503707
PNG
(US11034671, Example 101)
Show SMILES FC(F)(F)c1ccc(cn1)-c1ccc2COCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C24H19F3N6O2/c25-24(26,27)20-8-7-16(12-28-20)15-5-6-17-13-35-10-2-9-33-14-29-32-22(33)19-3-1-4-21(30-19)31-23(34)18(17)11-15/h1,3-8,11-12,14H,2,9-10,13H2,(H,30,31,34)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503708
PNG
(US11034671, Example 102)
Show SMILES CCc1ccc(cn1)-c1ccc2COCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C25H24N6O2/c1-2-20-10-9-18(14-26-20)17-7-8-19-15-33-12-4-11-31-16-27-30-24(31)22-5-3-6-23(28-22)29-25(32)21(19)13-17/h3,5-10,13-14,16H,2,4,11-12,15H2,1H3,(H,28,29,32)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503713
PNG
(US11034671, Example 107)
Show SMILES Fc1cc(cnc1F)-c1ccc2COCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C23H18F2N6O2/c24-18-10-16(11-26-21(18)25)14-5-6-15-12-33-8-2-7-31-13-27-30-22(31)19-3-1-4-20(28-19)29-23(32)17(15)9-14/h1,3-6,9-11,13H,2,7-8,12H2,(H,28,29,32)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503622
PNG
(US11034671, Example 9)
Show SMILES O=C1Nc2cccc(n2)-c2nncn2CCCCCCOc2ccc(cc12)-c1ccc(nc1)C1CC1
Show InChI InChI=1S/C28H28N6O2/c35-28-22-16-20(21-10-12-23(29-17-21)19-8-9-19)11-13-25(22)36-15-4-2-1-3-14-34-18-30-33-27(34)24-6-5-7-26(31-24)32-28/h5-7,10-13,16-19H,1-4,8-9,14-15H2,(H,31,32,35)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503630
PNG
(US11034671, Example 17)
Show SMILES O=C1Nc2cccc(n2)-c2nncn2C\C=C\CCOc2ccc(OCc3ccccc3)cc12
Show InChI InChI=1S/C26H23N5O3/c32-26-21-16-20(34-17-19-8-3-1-4-9-19)12-13-23(21)33-15-6-2-5-14-31-18-27-30-25(31)22-10-7-11-24(28-22)29-26/h1-5,7-13,16,18H,6,14-15,17H2,(H,28,29,32)/b5-2+
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM50505952
PNG
(CHEMBL4475667 | US11034671, Example 48)
Show SMILES Cn1cc(cn1)-c1ccc2OCCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C22H21N7O2/c1-28-13-16(12-24-28)15-7-8-19-17(11-15)22(30)26-20-6-4-5-18(25-20)21-27-23-14-29(21)9-2-3-10-31-19/h4-8,11-14H,2-3,9-10H2,1H3,(H,25,26,30)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503659
PNG
(US11034671, Example 50)
Show SMILES CC1CCCOc2ccc(cc2C(=O)Nc2cccc(n2)-c2nncn12)-c1ccc(nc1)C1CC1
Show InChI InChI=1S/C27H26N6O2/c1-17-4-3-13-35-24-12-10-19(20-9-11-22(28-15-20)18-7-8-18)14-21(24)27(34)31-25-6-2-5-23(30-25)26-32-29-16-33(17)26/h2,5-6,9-12,14-18H,3-4,7-8,13H2,1H3,(H,30,31,34)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503676
PNG
(US11034671, Example 68)
Show SMILES Fc1cc2OCCCCn3cnnc3-c3cccc(NC(=O)c2cc1-c1ccc(nc1)C1CC1)n3
Show InChI InChI=1S/C26H23FN6O2/c27-20-13-23-19(12-18(20)17-8-9-21(28-14-17)16-6-7-16)26(34)31-24-5-3-4-22(30-24)25-32-29-15-33(25)10-1-2-11-35-23/h3-5,8-9,12-16H,1-2,6-7,10-11H2,(H,30,31,34)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503679
PNG
(US11034671, Example 71)
Show SMILES Cc1ccc(cn1)-c1ccc2OC3CC[C@@H](CC3)n3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C26H24N6O2/c1-16-5-6-18(14-27-16)17-7-12-23-21(13-17)26(33)30-24-4-2-3-22(29-24)25-31-28-15-32(25)19-8-10-20(34-23)11-9-19/h2-7,12-15,19-20H,8-11H2,1H3,(H,29,30,33)/t19-,20?
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503682
PNG
(US11034671, Example 74)
Show SMILES Cc1ncc(cc1F)-c1ccc2OCCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C24H21FN6O2/c1-15-19(25)12-17(13-26-15)16-7-8-21-18(11-16)24(32)29-22-6-4-5-20(28-22)23-30-27-14-31(23)9-2-3-10-33-21/h4-8,11-14H,2-3,9-10H2,1H3,(H,28,29,32)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503687
PNG
(US11034671, Example 80)
Show SMILES CC1CCOc2ccc(cc2C(=O)Nc2cccc(n2)-c2nncn2C1)-c1ccc(C)nc1
Show InChI InChI=1S/C25H24N6O2/c1-16-10-11-33-22-9-8-18(19-7-6-17(2)26-13-19)12-20(22)25(32)29-23-5-3-4-21(28-23)24-30-27-15-31(24)14-16/h3-9,12-13,15-16H,10-11,14H2,1-2H3,(H,28,29,32)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503705
PNG
(US11034671, Example 99)
Show SMILES Fc1ncc(cc1Cl)-c1ccc2OCCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C23H18ClFN6O2/c24-17-11-15(12-26-21(17)25)14-6-7-19-16(10-14)23(32)29-20-5-3-4-18(28-20)22-30-27-13-31(22)8-1-2-9-33-19/h3-7,10-13H,1-2,8-9H2,(H,28,29,32)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503710
PNG
(US11034671, Example 104)
Show SMILES C[C@@H]1CCn2cnnc2-c2cccc(NC(=O)c3cc(ccc3OC1)-c1ccc(C)nc1)n2
Show InChI InChI=1S/C25H24N6O2/c1-16-10-11-31-15-27-30-24(31)21-4-3-5-23(28-21)29-25(32)20-12-18(8-9-22(20)33-14-16)19-7-6-17(2)26-13-19/h3-9,12-13,15-16H,10-11,14H2,1-2H3,(H,28,29,32)/t16-/m1/s1
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503616
PNG
(US11034671, Example 3)
Show SMILES COc1ccc2OC\C=C\CCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C21H21N5O3/c1-28-15-9-10-18-16(13-15)21(27)24-19-8-6-7-17(23-19)20-25-22-14-26(20)11-4-2-3-5-12-29-18/h3,5-10,13-14H,2,4,11-12H2,1H3,(H,23,24,27)/b5-3+
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503628
PNG
(US11034671, Example 15)
Show SMILES COc1ccc2CCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C19H19N5O2/c1-26-14-9-8-13-5-2-3-10-24-12-20-23-18(24)16-6-4-7-17(21-16)22-19(25)15(13)11-14/h4,6-9,11-12H,2-3,5,10H2,1H3,(H,21,22,25)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503648
PNG
(US11034671, Example 38)
Show SMILES O=C1Nc2cccc(n2)-c2nncn2CCCCOc2ccc(cc12)-c1ccccc1
Show InChI InChI=1S/C24H21N5O2/c30-24-19-15-18(17-7-2-1-3-8-17)11-12-21(19)31-14-5-4-13-29-16-25-28-23(29)20-9-6-10-22(26-20)27-24/h1-3,6-12,15-16H,4-5,13-14H2,(H,26,27,30)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM50505950
PNG
(CHEMBL4548492 | US11034671, Example 43)
Show SMILES O=C1Nc2cccc(n2)-c2nncn2CCCCOc2ccc(cc12)N1CCOCC1
Show InChI InChI=1S/C22H24N6O3/c29-22-17-14-16(27-9-12-30-13-10-27)6-7-19(17)31-11-2-1-8-28-15-23-26-21(28)18-4-3-5-20(24-18)25-22/h3-7,14-15H,1-2,8-13H2,(H,24,25,29)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503654
PNG
(US11034671, Example 44)
Show SMILES Fc1cc2OCCCCn3cnnc3-c3cccc(NC(=O)c2cc1C#N)n3
Show InChI InChI=1S/C19H15FN6O2/c20-14-9-16-13(8-12(14)10-21)19(27)24-17-5-3-4-15(23-17)18-25-22-11-26(18)6-1-2-7-28-16/h3-5,8-9,11H,1-2,6-7H2,(H,23,24,27)
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n/an/an/a 300n/an/an/an/an/a



SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503660
PNG
(US11034671, Example 51)
Show SMILES Cc1ccc(cn1)-c1cc2c(OCCCCn3cnnc3-c3cccc(NC2=O)n3)cc1C
Show InChI InChI=1S/C25H24N6O2/c1-16-12-22-20(13-19(16)18-9-8-17(2)26-14-18)25(32)29-23-7-5-6-21(28-23)24-30-27-15-31(24)10-3-4-11-33-22/h5-9,12-15H,3-4,10-11H2,1-2H3,(H,28,29,32)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503668
PNG
(US11034671, Example 59)
Show SMILES COc1cc2c(OCCCCn3cnnc3-c3cccc(NC2=O)n3)cc1Br
Show InChI InChI=1S/C19H18BrN5O3/c1-27-16-9-12-15(10-13(16)20)28-8-3-2-7-25-11-21-24-18(25)14-5-4-6-17(22-14)23-19(12)26/h4-6,9-11H,2-3,7-8H2,1H3,(H,22,23,26)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503670
PNG
(US11034671, Example 61)
Show SMILES Cc1cc2OCCCCn3cnnc3-c3cccc(NC(=O)c2cc1-n1cnc(c1)C1CC1)n3
Show InChI InChI=1S/C25H25N7O2/c1-16-11-22-18(12-21(16)32-13-20(26-14-32)17-7-8-17)25(33)29-23-6-4-5-19(28-23)24-30-27-15-31(24)9-2-3-10-34-22/h4-6,11-15,17H,2-3,7-10H2,1H3,(H,28,29,33)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503671
PNG
(US11034671, Example 63)
Show SMILES O=C1Nc2cccc(n2)-c2nncn2CCCCOc2ccc(cc12)-c1ccc(nc1)C#N
Show InChI InChI=1S/C24H19N7O2/c25-13-18-8-6-17(14-26-18)16-7-9-21-19(12-16)24(32)29-22-5-3-4-20(28-22)23-30-27-15-31(23)10-1-2-11-33-21/h3-9,12,14-15H,1-2,10-11H2,(H,28,29,32)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503673
PNG
(US11034671, Example 65)
Show SMILES Cc1cc2OCCCCn3cnnc3-c3cccc(NC(=O)c2cc1-c1ccc(nc1)C1CC1)n3
Show InChI InChI=1S/C27H26N6O2/c1-17-13-24-21(14-20(17)19-9-10-22(28-15-19)18-7-8-18)27(34)31-25-6-4-5-23(30-25)26-32-29-16-33(26)11-2-3-12-35-24/h4-6,9-10,13-16,18H,2-3,7-8,11-12H2,1H3,(H,30,31,34)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503683
PNG
(US11034671, Example 75)
Show SMILES Cc1ncc(cc1Cl)-c1ccc2OCCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C24H21ClN6O2/c1-15-19(25)12-17(13-26-15)16-7-8-21-18(11-16)24(32)29-22-6-4-5-20(28-22)23-30-27-14-31(23)9-2-3-10-33-21/h4-8,11-14H,2-3,9-10H2,1H3,(H,28,29,32)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503689
PNG
(US11034671, Example 82)
Show SMILES FC(F)c1ccc(cn1)-c1ccc2COCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C24H20F2N6O2/c25-22(26)19-8-7-16(12-27-19)15-5-6-17-13-34-10-2-9-32-14-28-31-23(32)20-3-1-4-21(29-20)30-24(33)18(17)11-15/h1,3-8,11-12,14,22H,2,9-10,13H2,(H,29,30,33)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503690
PNG
(US11034671, Example 83)
Show SMILES CC1CCOc2ccc(cc2C(=O)Nc2cccc(n2)-c2nncn12)-c1ccc(nc1)C(F)F
Show InChI InChI=1S/C24H20F2N6O2/c1-14-9-10-34-20-8-6-15(16-5-7-18(22(25)26)27-12-16)11-17(20)24(33)30-21-4-2-3-19(29-21)23-31-28-13-32(14)23/h2-8,11-14,22H,9-10H2,1H3,(H,29,30,33)
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n/an/an/a 1.50E+3n/an/an/an/an/a



SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503695
PNG
(US11034671, Example 89)
Show SMILES C[C@@H]1CCCOc2ccc(cc2C(=O)Nc2cccc(n2)-c2nncn12)-c1ccc(C)nc1
Show InChI InChI=1S/C25H24N6O2/c1-16-8-9-19(14-26-16)18-10-11-22-20(13-18)25(32)29-23-7-3-6-21(28-23)24-30-27-15-31(24)17(2)5-4-12-33-22/h3,6-11,13-15,17H,4-5,12H2,1-2H3,(H,28,29,32)/t17-/m1/s1
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503701
PNG
(US11034671, Example 95)
Show SMILES O=C1Nc2cccc(n2)-c2nncn2CCCOCc2ccc(cc12)-c1ccc(nc1)C1CC1
Show InChI InChI=1S/C26H24N6O2/c33-26-21-13-18(19-9-10-22(27-14-19)17-5-6-17)7-8-20(21)15-34-12-2-11-32-16-28-31-25(32)23-3-1-4-24(29-23)30-26/h1,3-4,7-10,13-14,16-17H,2,5-6,11-12,15H2,(H,29,30,33)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503704
PNG
(US11034671, Example 98)
Show SMILES Fc1cc(cnc1F)-c1ccc2OCCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C23H18F2N6O2/c24-17-11-15(12-26-21(17)25)14-6-7-19-16(10-14)23(32)29-20-5-3-4-18(28-20)22-30-27-13-31(22)8-1-2-9-33-19/h3-7,10-13H,1-2,8-9H2,(H,28,29,32)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503709
PNG
(US11034671, Example 103)
Show SMILES O=C1Nc2cccc(n2)-c2nncn2CCCOCc2ccc(cc12)-n1cnc(c1)C1CC1
Show InChI InChI=1S/C24H23N7O2/c32-24-19-11-18(31-12-21(25-14-31)16-5-6-16)8-7-17(19)13-33-10-2-9-30-15-26-29-23(30)20-3-1-4-22(27-20)28-24/h1,3-4,7-8,11-12,14-16H,2,5-6,9-10,13H2,(H,27,28,32)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 5


(Homo sapiens (Human))
BDBM503712
PNG
(US11034671, Example 106)
Show SMILES Fc1ncc(cc1Cl)-c1ccc2COCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
Show InChI InChI=1S/C23H18ClFN6O2/c24-18-10-16(11-26-21(18)25)14-5-6-15-12-33-8-2-7-31-13-27-30-22(31)19-3-1-4-20(28-19)29-23(32)17(15)9-14/h1,3-6,9-11,13H,2,7-8,12H2,(H,28,29,32)
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SICHUAN HAISCO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...


US Patent US11034671 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%