Affinity Data by Patent

Patent code US11040967

Found 15 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM406678 (US10336752, Compound 16 \| US11040967, Compound 16) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	17.7	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Compounds were serially diluted in DMSO then further diluted in 1� kinase buffer: 5 uL of buffer diluted compound was added into wells first, then 10...				US Patent US11040967 (2021)
Nimbus Lakshmi, Inc. US Patent					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332998 (US10196390, Compound I-287 \| US10336752, Compound ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	24.2	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Compounds were serially diluted in DMSO then further diluted in 1� kinase buffer: 5 uL of buffer diluted compound was added into wells first, then 10...				US Patent US11040967 (2021)
Nimbus Lakshmi, Inc. US Patent					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332882 (US10196390, Compound I-171 \| US10336752, Compound ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Compounds were serially diluted in DMSO then further diluted in 1� kinase buffer: 5 uL of buffer diluted compound was added into wells first, then 10...				US Patent US11040967 (2021)
Nimbus Lakshmi, Inc. US Patent					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM406663 (US10336752, Compound 1 \| US10336752, Compound 2 \| ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	56.9	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Compounds were serially diluted in DMSO then further diluted in 1� kinase buffer: 5 uL of buffer diluted compound was added into wells first, then 10...				US Patent US11040967 (2021)
Nimbus Lakshmi, Inc. US Patent					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM406663 (US10336752, Compound 1 \| US10336752, Compound 2 \| ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	72.6	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Compounds were serially diluted in DMSO then further diluted in 1� kinase buffer: 5 uL of buffer diluted compound was added into wells first, then 10...				US Patent US11040967 (2021)
Nimbus Lakshmi, Inc. US Patent					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM406676 (US10336752, Compound 15 \| US11040967, Compound 15) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	74.1	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Compounds were serially diluted in DMSO then further diluted in 1� kinase buffer: 5 uL of buffer diluted compound was added into wells first, then 10...				US Patent US11040967 (2021)
Nimbus Lakshmi, Inc. US Patent					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM406663 (US10336752, Compound 1 \| US10336752, Compound 2 \| ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	78.5	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Compounds were serially diluted in DMSO then further diluted in 1� kinase buffer: 5 uL of buffer diluted compound was added into wells first, then 10...				US Patent US11040967 (2021)
Nimbus Lakshmi, Inc. US Patent					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM406663 (US10336752, Compound 1 \| US10336752, Compound 2 \| ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	85.3	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Compounds were serially diluted in DMSO then further diluted in 1� kinase buffer: 5 uL of buffer diluted compound was added into wells first, then 10...				US Patent US11040967 (2021)
Nimbus Lakshmi, Inc. US Patent					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM406679 (US10336752, Compound 17 \| US10968236, Compound I-6...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	88.6	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Compounds were serially diluted in DMSO then further diluted in 1� kinase buffer: 5 uL of buffer diluted compound was added into wells first, then 10...				US Patent US11040967 (2021)
Nimbus Lakshmi, Inc. US Patent					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332968 (US10196390, Compound I-257 \| US10336752, Compound ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Compounds were serially diluted in DMSO then further diluted in 1� kinase buffer: 5 uL of buffer diluted compound was added into wells first, then 10...				US Patent US11040967 (2021)
Nimbus Lakshmi, Inc. US Patent					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM406663 (US10336752, Compound 1 \| US10336752, Compound 2 \| ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	93.2	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Compounds were serially diluted in DMSO then further diluted in 1� kinase buffer: 5 uL of buffer diluted compound was added into wells first, then 10...				US Patent US11040967 (2021)
Nimbus Lakshmi, Inc. US Patent					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332970 (US10196390, Compound I-259 \| US10336752, Compound ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	119	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Compounds were serially diluted in DMSO then further diluted in 1� kinase buffer: 5 uL of buffer diluted compound was added into wells first, then 10...				US Patent US11040967 (2021)
Nimbus Lakshmi, Inc. US Patent					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332942 (US10196390, Compound I-231 \| US10336752, Compound ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	134	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Compounds were serially diluted in DMSO then further diluted in 1� kinase buffer: 5 uL of buffer diluted compound was added into wells first, then 10...				US Patent US11040967 (2021)
Nimbus Lakshmi, Inc. US Patent					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332986 (US10196390, Compound I-275 \| US10336752, Compound ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	136	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Compounds were serially diluted in DMSO then further diluted in 1� kinase buffer: 5 uL of buffer diluted compound was added into wells first, then 10...				US Patent US11040967 (2021)
Nimbus Lakshmi, Inc. US Patent					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM332916 (US10196390, Compound I-205 \| US10336752, Compound ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Compounds were serially diluted in DMSO then further diluted in 1� kinase buffer: 5 uL of buffer diluted compound was added into wells first, then 10...				US Patent US11040967 (2021)
Nimbus Lakshmi, Inc. US Patent					More data for this Ligand-Target Pair

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* indicates data uncertainty>20%