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Patent code US11040970

Compile Data Set for Download or QSAR
Found 54 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504362
PNG
(US11040970, Compound 5-16)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)C)CN3CCc2cc1OC1CCC1
Show InChI InChI=1S/C22H34N2O2/c1-15(2)10-17-13-24-9-8-16-11-22(26-18-6-5-7-18)21(25-4)12-19(16)20(24)14-23(17)3/h11-12,15,17-18,20H,5-10,13-14H2,1-4H3/t17-,20?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504365
PNG
(US11040970, Compound 5-19)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)C)CN3CCc2cc1OCCC(F)(F)F
Show InChI InChI=1S/C21H31F3N2O2/c1-14(2)9-16-12-26-7-5-15-10-20(28-8-6-21(22,23)24)19(27-4)11-17(15)18(26)13-25(16)3/h10-11,14,16,18H,5-9,12-13H2,1-4H3/t16-,18?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504363
PNG
(US11040970, Compound 5-17)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)C)CN3CCc2cc1OCC(F)(F)F
Show InChI InChI=1S/C20H29F3N2O2/c1-13(2)7-15-10-25-6-5-14-8-19(27-12-20(21,22)23)18(26-4)9-16(14)17(25)11-24(15)3/h8-9,13,15,17H,5-7,10-12H2,1-4H3/t15-,17?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504361
PNG
(US11040970, Compound 5-15)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)C)CN3CCc2cc1OCC1CC1
Show InChI InChI=1S/C22H34N2O2/c1-15(2)9-18-12-24-8-7-17-10-22(26-14-16-5-6-16)21(25-4)11-19(17)20(24)13-23(18)3/h10-11,15-16,18,20H,5-9,12-14H2,1-4H3/t18-,20?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504356
PNG
(US11040970, Compound 5-11)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)C)CN3CCc2cc1OCC1CCC1
Show InChI InChI=1S/C23H36N2O2/c1-16(2)10-19-13-25-9-8-18-11-23(27-15-17-6-5-7-17)22(26-4)12-20(18)21(25)14-24(19)3/h11-12,16-17,19,21H,5-10,13-15H2,1-4H3/t19-,21?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504388
PNG
(US11040970, Compound 11-9)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)(C)C)CN3CCc2cc1OCCCC(F)(F)F
Show InChI InChI=1S/C23H35F3N2O2/c1-22(2,3)13-17-14-28-9-7-16-11-21(30-10-6-8-23(24,25)26)20(29-5)12-18(16)19(28)15-27(17)4/h11-12,17,19H,6-10,13-15H2,1-5H3/t17-,19?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504370
PNG
(US11040970, Compound 8-2)
Show SMILES COc1cc2C3CN(C)[C@H](CC4CCC4)CN3CCc2cc1OCC(F)(F)F
Show InChI InChI=1S/C21H29F3N2O2/c1-25-12-18-17-10-19(27-2)20(28-13-21(22,23)24)9-15(17)6-7-26(18)11-16(25)8-14-4-3-5-14/h9-10,14,16,18H,3-8,11-13H2,1-2H3/t16-,18?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504364
PNG
(US11040970, Compound 5-18)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)C)CN3CCc2cc1OCC1CC1(F)F
Show InChI InChI=1S/C22H32F2N2O2/c1-14(2)7-17-11-26-6-5-15-8-21(28-13-16-10-22(16,23)24)20(27-4)9-18(15)19(26)12-25(17)3/h8-9,14,16-17,19H,5-7,10-13H2,1-4H3/t16?,17-,19?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504358
PNG
(US11040970, Compound 5-13)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)C)CN3CCc2cc1OCCCC(F)(F)F
Show InChI InChI=1S/C22H33F3N2O2/c1-15(2)10-17-13-27-8-6-16-11-21(29-9-5-7-22(23,24)25)20(28-4)12-18(16)19(27)14-26(17)3/h11-12,15,17,19H,5-10,13-14H2,1-4H3/t17-,19?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504384
PNG
(US11040970, Compound 11-5 | US11040970, Compound 1...)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)(C)C)CN3CCc2cc1OCCC(F)(F)F
Show InChI InChI=1S/C22H33F3N2O2/c1-21(2,3)12-16-13-27-8-6-15-10-20(29-9-7-22(23,24)25)19(28-5)11-17(15)18(27)14-26(16)4/h10-11,16,18H,6-9,12-14H2,1-5H3/t16-,18?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504353
PNG
(US11040970, Compound 5-8)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)C)CN3CCc2cc1OCC=C
Show InChI InChI=1S/C21H32N2O2/c1-6-9-25-21-11-16-7-8-23-13-17(10-15(2)3)22(4)14-19(23)18(16)12-20(21)24-5/h6,11-12,15,17,19H,1,7-10,13-14H2,2-5H3/t17-,19?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504351
PNG
(US11040970, Compound 5-6)
Show SMILES CCCOc1cc2CCN3C[C@@H](CC(C)C)N(C)CC3c2cc1OC
Show InChI InChI=1S/C21H34N2O2/c1-6-9-25-21-11-16-7-8-23-13-17(10-15(2)3)22(4)14-19(23)18(16)12-20(21)24-5/h11-12,15,17,19H,6-10,13-14H2,1-5H3/t17-,19?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504345
PNG
(US11040970, Compound 5-1)
Show SMILES CCOc1cc2CCN3C[C@@H](CC(C)C)N(C)CC3c2cc1OC
Show InChI InChI=1S/C20H32N2O2/c1-6-24-20-10-15-7-8-22-12-16(9-14(2)3)21(4)13-18(22)17(15)11-19(20)23-5/h10-11,14,16,18H,6-9,12-13H2,1-5H3/t16-,18?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504392
PNG
(US11040970, Compound 11-13)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)(C)C)CN3CCc2cc1OC(C)C
Show InChI InChI=1S/C22H36N2O2/c1-15(2)26-21-10-16-8-9-24-13-17(12-22(3,4)5)23(6)14-19(24)18(16)11-20(21)25-7/h10-11,15,17,19H,8-9,12-14H2,1-7H3/t17-,19?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504389
PNG
(US11040970, Compound 11-10)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)(C)C)CN3CCc2cc1OCCCCF
Show InChI InChI=1S/C23H37FN2O2/c1-23(2,3)14-18-15-26-10-8-17-12-22(28-11-7-6-9-24)21(27-5)13-19(17)20(26)16-25(18)4/h12-13,18,20H,6-11,14-16H2,1-5H3/t18-,20?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504387
PNG
(US11040970, Compound 11-8)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)(C)C)CN3CCc2cc1OCC1CCC1
Show InChI InChI=1S/C24H38N2O2/c1-24(2,3)13-19-14-26-10-9-18-11-23(28-16-17-7-6-8-17)22(27-5)12-20(18)21(26)15-25(19)4/h11-12,17,19,21H,6-10,13-16H2,1-5H3/t19-,21?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504386
PNG
(US11040970, Compound 11-7)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)(C)C)CN3CCc2cc1OCC1CC1
Show InChI InChI=1S/C23H36N2O2/c1-23(2,3)12-18-13-25-9-8-17-10-22(27-15-16-6-7-16)21(26-5)11-19(17)20(25)14-24(18)4/h10-11,16,18,20H,6-9,12-15H2,1-5H3/t18-,20?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504380
PNG
(US11040970, Compound 11-1 | US11040970, Compound 1...)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)(C)C)CN3CCc2cc1OCCCF
Show InChI InChI=1S/C22H35FN2O2/c1-22(2,3)13-17-14-25-9-7-16-11-21(27-10-6-8-23)20(26-5)12-18(16)19(25)15-24(17)4/h11-12,17,19H,6-10,13-15H2,1-5H3/t17-,19?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504359
PNG
(US11040970, Compound 5-14)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)C)CN3CCc2cc1OCCCCF
Show InChI InChI=1S/C22H35FN2O2/c1-16(2)11-18-14-25-9-7-17-12-22(27-10-6-5-8-23)21(26-4)13-19(17)20(25)15-24(18)3/h12-13,16,18,20H,5-11,14-15H2,1-4H3/t18-,20?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504376
PNG
(US11040970, Compound 8-6)
Show SMILES COc1cc2C3CN(C)[C@H](CC4CCC4)CN3CCc2cc1OCC1CCC1
Show InChI InChI=1S/C24H36N2O2/c1-25-15-22-21-13-23(27-2)24(28-16-18-7-4-8-18)12-19(21)9-10-26(22)14-20(25)11-17-5-3-6-17/h12-13,17-18,20,22H,3-11,14-16H2,1-2H3/t20-,22?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504391
PNG
(US11040970, Compound 11-12 | US11040970, Compound ...)
Show SMILES CCOc1cc2CCN3C[C@@H](CC(C)(C)C)N(C)CC3c2cc1OC
Show InChI InChI=1S/C21H34N2O2/c1-7-25-20-10-15-8-9-23-13-16(12-21(2,3)4)22(5)14-18(23)17(15)11-19(20)24-6/h10-11,16,18H,7-9,12-14H2,1-6H3/t16-,18?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504384
PNG
(US11040970, Compound 11-5 | US11040970, Compound 1...)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)(C)C)CN3CCc2cc1OCCC(F)(F)F
Show InChI InChI=1S/C22H33F3N2O2/c1-21(2,3)12-16-13-27-8-6-15-10-20(29-9-7-22(23,24)25)19(28-5)11-17(15)18(27)14-26(16)4/h10-11,16,18H,6-9,12-14H2,1-5H3/t16-,18?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504382
PNG
(US11040970, Compound 11-3)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)(C)C)CN3CCc2cc1OCC(F)(F)F
Show InChI InChI=1S/C21H31F3N2O2/c1-20(2,3)10-15-11-26-7-6-14-8-19(28-13-21(22,23)24)18(27-5)9-16(14)17(26)12-25(15)4/h8-9,15,17H,6-7,10-13H2,1-5H3/t15-,17?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504381
PNG
(US11040970, Compound 11-2 | US11040970, Compound 1...)
Show SMILES COc1cc2CCN3C[C@@H](CC(C)(C)C)N(C)CC3c2cc1OC
Show InChI InChI=1S/C20H32N2O2/c1-20(2,3)11-15-12-22-8-7-14-9-18(23-5)19(24-6)10-16(14)17(22)13-21(15)4/h9-10,15,17H,7-8,11-13H2,1-6H3/t15-,17?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504352
PNG
(US11040970, Compound 5-7)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)C)CN3CCc2cc1OC1CCCC1
Show InChI InChI=1S/C23H36N2O2/c1-16(2)11-18-14-25-10-9-17-12-23(27-19-7-5-6-8-19)22(26-4)13-20(17)21(25)15-24(18)3/h12-13,16,18-19,21H,5-11,14-15H2,1-4H3/t18-,21?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504391
PNG
(US11040970, Compound 11-12 | US11040970, Compound ...)
Show SMILES CCOc1cc2CCN3C[C@@H](CC(C)(C)C)N(C)CC3c2cc1OC
Show InChI InChI=1S/C21H34N2O2/c1-7-25-20-10-15-8-9-23-13-16(12-21(2,3)4)22(5)14-18(23)17(15)11-19(20)24-6/h10-11,16,18H,7-9,12-14H2,1-6H3/t16-,18?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504354
PNG
(US11040970, Compound 5-9 | US11040970, Compound 6-...)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)C)CN3CCc2cc1OCC(C)C
Show InChI InChI=1S/C22H36N2O2/c1-15(2)9-18-12-24-8-7-17-10-22(26-14-16(3)4)21(25-6)11-19(17)20(24)13-23(18)5/h10-11,15-16,18,20H,7-9,12-14H2,1-6H3/t18-,20?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504383
PNG
(US11040970, Compound 11-4)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)(C)C)CN3CCc2cc1OCC1CC1(F)F
Show InChI InChI=1S/C23H34F2N2O2/c1-22(2,3)11-17-12-27-7-6-15-8-21(29-14-16-10-23(16,24)25)20(28-5)9-18(15)19(27)13-26(17)4/h8-9,16-17,19H,6-7,10-14H2,1-5H3/t16?,17-,19?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504380
PNG
(US11040970, Compound 11-1 | US11040970, Compound 1...)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)(C)C)CN3CCc2cc1OCCCF
Show InChI InChI=1S/C22H35FN2O2/c1-22(2,3)13-17-14-25-9-7-16-11-21(27-10-6-8-23)20(26-5)12-18(16)19(25)15-24(17)4/h11-12,17,19H,6-10,13-15H2,1-5H3/t17-,19?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504377
PNG
(US11040970, Compound 8-7)
Show SMILES CCCCOc1cc2CCN3C[C@@H](CC4CCC4)N(C)CC3c2cc1OC
Show InChI InChI=1S/C23H36N2O2/c1-4-5-11-27-23-13-18-9-10-25-15-19(12-17-7-6-8-17)24(2)16-21(25)20(18)14-22(23)26-3/h13-14,17,19,21H,4-12,15-16H2,1-3H3/t19-,21?/m1/s1
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260n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504347
PNG
(US11040970, Compound 5-3)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)C)CN3CCc2cc1OCCC(F)F
Show InChI InChI=1S/C21H32F2N2O2/c1-14(2)9-16-12-25-7-5-15-10-20(27-8-6-21(22)23)19(26-4)11-17(15)18(25)13-24(16)3/h10-11,14,16,18,21H,5-9,12-13H2,1-4H3/t16-,18?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504350
PNG
(US11040970, Compound 5-5 | US11040970, Compound 6-...)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)C)CN3CCc2cc1OC1CC1
Show InChI InChI=1S/C21H32N2O2/c1-14(2)9-16-12-23-8-7-15-10-21(25-17-5-6-17)20(24-4)11-18(15)19(23)13-22(16)3/h10-11,14,16-17,19H,5-9,12-13H2,1-4H3/t16-,19?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504372
PNG
(US11040970, Compound 8-4)
Show SMILES COc1cc2C3CN(C)[C@H](CC4CCC4)CN3CCc2cc1OCCF
Show InChI InChI=1S/C21H31FN2O2/c1-23-14-19-18-12-20(25-2)21(26-9-7-22)11-16(18)6-8-24(19)13-17(23)10-15-4-3-5-15/h11-12,15,17,19H,3-10,13-14H2,1-2H3/t17-,19?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504357
PNG
(US11040970, Compound 5-12)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)C)CN3CCc2cc1OCCC#N
Show InChI InChI=1S/C21H31N3O2/c1-15(2)10-17-13-24-8-6-16-11-21(26-9-5-7-22)20(25-4)12-18(16)19(24)14-23(17)3/h11-12,15,17,19H,5-6,8-10,13-14H2,1-4H3/t17-,19?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504369
PNG
(US11040970, Compound 8-1 | US11040970, Compound 9-...)
Show SMILES COc1cc2C3CN(C)[C@H](CC4CCC4)CN3CCc2cc1OCCCF
Show InChI InChI=1S/C22H33FN2O2/c1-24-15-20-19-13-21(26-2)22(27-10-4-8-23)12-17(19)7-9-25(20)14-18(24)11-16-5-3-6-16/h12-13,16,18,20H,3-11,14-15H2,1-2H3/t18-,20?/m1/s1
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260n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504378
PNG
(US11040970, Compound 8-8)
Show SMILES COc1cc2C3CN(C)[C@H](CC4CCC4)CN3CCc2cc1OCCCCF
Show InChI InChI=1S/C23H35FN2O2/c1-25-16-21-20-14-22(27-2)23(28-11-4-3-9-24)13-18(20)8-10-26(21)15-19(25)12-17-6-5-7-17/h13-14,17,19,21H,3-12,15-16H2,1-2H3/t19-,21?/m1/s1
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260n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504346
PNG
(US11040970, Compound 5-2 | US11040970, Compound 6-...)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)C)CN3CCc2cc1OC(C)C
Show InChI InChI=1S/C21H34N2O2/c1-14(2)9-17-12-23-8-7-16-10-21(25-15(3)4)20(24-6)11-18(16)19(23)13-22(17)5/h10-11,14-15,17,19H,7-9,12-13H2,1-6H3/t17-,19?/m1/s1
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260n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504390
PNG
(US11040970, Compound 11-11)
Show SMILES COCCOc1cc2CCN3C[C@@H](CC(C)(C)C)N(C)CC3c2cc1OC
Show InChI InChI=1S/C22H36N2O3/c1-22(2,3)13-17-14-24-8-7-16-11-21(27-10-9-25-5)20(26-6)12-18(16)19(24)15-23(17)4/h11-12,17,19H,7-10,13-15H2,1-6H3/t17-,19?/m1/s1
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260n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504338
PNG
(US11040970, Compound 2-2 | US11040970, Compound 3-...)
Show SMILES COc1cc2CCN3C[C@@H](CC(C)C)N(C)CC3c2cc1OC
Show InChI InChI=1S/C19H30N2O2/c1-13(2)8-15-11-21-7-6-14-9-18(22-4)19(23-5)10-16(14)17(21)12-20(15)3/h9-10,13,15,17H,6-8,11-12H2,1-5H3/t15-,17?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504349
PNG
(US11040970, Compound 5-4 | US11040970, Compound 6-...)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)C)CN3CCc2cc1OCCF
Show InChI InChI=1S/C20H31FN2O2/c1-14(2)9-16-12-23-7-5-15-10-20(25-8-6-21)19(24-4)11-17(15)18(23)13-22(16)3/h10-11,14,16,18H,5-9,12-13H2,1-4H3/t16-,18?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504373
PNG
(US11040970, Compound 8-5)
Show SMILES COc1cc2C3CN(C)[C@H](CC4CCC4)CN3CCc2cc1OCC1CC1
Show InChI InChI=1S/C23H34N2O2/c1-24-14-21-20-12-22(26-2)23(27-15-17-6-7-17)11-18(20)8-9-25(21)13-19(24)10-16-4-3-5-16/h11-12,16-17,19,21H,3-10,13-15H2,1-2H3/t19-,21?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504371
PNG
(US11040970, Compound 8-3)
Show SMILES COc1cc2C3CN(C)[C@H](CC4CCC4)CN3CCc2cc1OCC1CC1(F)F
Show InChI InChI=1S/C23H32F2N2O2/c1-26-13-20-19-10-21(28-2)22(29-14-17-11-23(17,24)25)9-16(19)6-7-27(20)12-18(26)8-15-4-3-5-15/h9-10,15,17-18,20H,3-8,11-14H2,1-2H3/t17?,18-,20?/m1/s1
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Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504337
PNG
(US11040970, Compound 2-1 | US11040970, Compound 3-...)
Show SMILES CCN1CC2N(CCc3cc(OC)c(OC)cc23)C[C@H]1CC(C)C
Show InChI InChI=1S/C20H32N2O2/c1-6-21-13-18-17-11-20(24-5)19(23-4)10-15(17)7-8-22(18)12-16(21)9-14(2)3/h10-11,14,16,18H,6-9,12-13H2,1-5H3/t16-,18?/m1/s1
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260n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504355
PNG
(US11040970, Compound 5-10)
Show SMILES COCCOc1cc2CCN3C[C@@H](CC(C)C)N(C)CC3c2cc1OC
Show InChI InChI=1S/C21H34N2O3/c1-15(2)10-17-13-23-7-6-16-11-21(26-9-8-24-4)20(25-5)12-18(16)19(23)14-22(17)3/h11-12,15,17,19H,6-10,13-14H2,1-5H3/t17-,19?/m1/s1
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260n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504349
PNG
(US11040970, Compound 5-4 | US11040970, Compound 6-...)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)C)CN3CCc2cc1OCCF
Show InChI InChI=1S/C20H31FN2O2/c1-14(2)9-16-12-23-7-5-15-10-20(25-8-6-21)19(24-4)11-17(15)18(23)13-22(16)3/h10-11,14,16,18H,5-9,12-13H2,1-4H3/t16-,18?/m1/s1
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>500n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504350
PNG
(US11040970, Compound 5-5 | US11040970, Compound 6-...)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)C)CN3CCc2cc1OC1CC1
Show InChI InChI=1S/C21H32N2O2/c1-14(2)9-16-12-23-8-7-15-10-21(25-17-5-6-17)20(24-4)11-18(15)19(23)13-22(16)3/h10-11,14,16-17,19H,5-9,12-13H2,1-4H3/t16-,19?/m1/s1
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>500n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504339
PNG
(US11040970, Compound 2-3 | US11040970, Compound 3-...)
Show SMILES COc1cc2CCN3C[C@@H](CC(C)C)N(CC(C)C)CC3c2cc1OC
Show InChI InChI=1S/C22H36N2O2/c1-15(2)9-18-13-23-8-7-17-10-21(25-5)22(26-6)11-19(17)20(23)14-24(18)12-16(3)4/h10-11,15-16,18,20H,7-9,12-14H2,1-6H3/t18-,20?/m1/s1
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>500n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504381
PNG
(US11040970, Compound 11-2 | US11040970, Compound 1...)
Show SMILES COc1cc2CCN3C[C@@H](CC(C)(C)C)N(C)CC3c2cc1OC
Show InChI InChI=1S/C20H32N2O2/c1-20(2,3)11-15-12-22-8-7-14-9-18(23-5)19(24-6)10-16(14)17(22)13-21(15)4/h9-10,15,17H,7-8,11-13H2,1-6H3/t15-,17?/m1/s1
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>500n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504339
PNG
(US11040970, Compound 2-3 | US11040970, Compound 3-...)
Show SMILES COc1cc2CCN3C[C@@H](CC(C)C)N(CC(C)C)CC3c2cc1OC
Show InChI InChI=1S/C22H36N2O2/c1-15(2)9-18-13-23-8-7-17-10-21(25-5)22(26-6)11-19(17)20(23)14-24(18)12-16(3)4/h10-11,15-16,18,20H,7-9,12-14H2,1-6H3/t18-,20?/m1/s1
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>500n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504354
PNG
(US11040970, Compound 5-9 | US11040970, Compound 6-...)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)C)CN3CCc2cc1OCC(C)C
Show InChI InChI=1S/C22H36N2O2/c1-15(2)9-18-12-24-8-7-17-10-22(26-14-16(3)4)21(25-6)11-19(17)20(24)13-23(18)5/h10-11,15-16,18,20H,7-9,12-14H2,1-6H3/t18-,20?/m1/s1
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>500n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504346
PNG
(US11040970, Compound 5-2 | US11040970, Compound 6-...)
Show SMILES COc1cc2C3CN(C)[C@H](CC(C)C)CN3CCc2cc1OC(C)C
Show InChI InChI=1S/C21H34N2O2/c1-14(2)9-17-12-23-8-7-16-10-21(25-15(3)4)20(24-6)11-18(16)19(23)13-22(17)5/h10-11,14-15,17,19H,7-9,12-13H2,1-6H3/t17-,19?/m1/s1
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>500n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504337
PNG
(US11040970, Compound 2-1 | US11040970, Compound 3-...)
Show SMILES CCN1CC2N(CCc3cc(OC)c(OC)cc23)C[C@H]1CC(C)C
Show InChI InChI=1S/C20H32N2O2/c1-6-21-13-18-17-11-20(24-5)19(23-4)10-15(17)7-8-22(18)12-16(21)9-14(2)3/h10-11,14,16,18H,6-9,12-13H2,1-5H3/t16-,18?/m1/s1
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>500n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504369
PNG
(US11040970, Compound 8-1 | US11040970, Compound 9-...)
Show SMILES COc1cc2C3CN(C)[C@H](CC4CCC4)CN3CCc2cc1OCCCF
Show InChI InChI=1S/C22H33FN2O2/c1-24-15-20-19-13-21(26-2)22(27-10-4-8-23)12-17(19)7-9-25(20)14-18(24)11-16-5-3-6-16/h12-13,16,18,20H,3-11,14-15H2,1-2H3/t18-,20?/m1/s1
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>500n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
Synaptic vesicular amine transporter


(Homo sapiens (Human))
BDBM504338
PNG
(US11040970, Compound 2-2 | US11040970, Compound 3-...)
Show SMILES COc1cc2CCN3C[C@@H](CC(C)C)N(C)CC3c2cc1OC
Show InChI InChI=1S/C19H30N2O2/c1-13(2)8-15-11-21-7-6-14-9-18(22-4)19(23-5)10-16(14)17(21)12-20(15)3/h9-10,13,15,17H,6-8,11-12H2,1-5H3/t15-,17?/m1/s1
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>500n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

US Patent


Assay Description
In a total volume of 0.15 mL in low-binding 96-well plates (Corning #3605), twelve concentrations of test compound were competed against 10 nM 3H-dih...


US Patent US11040970 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%