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Patent code US11040979

Compile Data Set for Download or QSAR
Found 20 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM504399
PNG
((S)-1-(2-(4-(3-chloro-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES Cn1cc(cn1)-c1cc2c(N3CCN(CC3)c3ncc(cn3)[C@@](C)(N)c3ccc(F)cc3)c(Cl)cnn2c1
Show InChI InChI=1S/C27H27ClFN9/c1-27(30,20-3-5-22(29)6-4-20)21-13-31-26(32-14-21)37-9-7-36(8-10-37)25-23(28)15-34-38-17-18(11-24(25)38)19-12-33-35(2)16-19/h3-6,11-17H,7-10,30H2,1-2H3/t27-/m0/s1
PDB

GoogleScholar
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...


US Patent US11040979 (2021)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM504398
PNG
((S)-1-(2-(4-(3-fluoro-6-(1-methyl-11H-pyrazol-4-yl...)
Show SMILES Cn1cc(cn1)-c1cc2c(N3CCN(CC3)c3ncc(cn3)[C@@](C)(N)c3ccc(F)cc3)c(F)cnn2c1
Show InChI InChI=1S/C27H27F2N9/c1-27(30,20-3-5-22(28)6-4-20)21-13-31-26(32-14-21)37-9-7-36(8-10-37)25-23(29)15-34-38-17-18(11-24(25)38)19-12-33-35(2)16-19/h3-6,11-17H,7-10,30H2,1-2H3/t27-/m0/s1
PDB

GoogleScholar
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...


US Patent US11040979 (2021)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM504397
PNG
((S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyr...)
Show SMILES Cn1cc(cn1)-c1cc2c(ccnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1
Show InChI InChI=1S/C27H28FN9/c1-27(29,21-3-5-23(28)6-4-21)22-15-30-26(31-16-22)36-11-9-35(10-12-36)24-7-8-32-37-18-19(13-25(24)37)20-14-33-34(2)17-20/h3-8,13-18H,9-12,29H2,1-2H3/t27-/m0/s1
PDB

GoogleScholar
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...


US Patent US11040979 (2021)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (D842V)


(Homo sapiens (Human))
BDBM504400
PNG
((S)-4-(4-(5-(1-amino-1-(4-fluorophenyl)ethyl)pyrim...)
Show SMILES Cn1cc(cn1)-c1cc2c(N3CCN(CC3)c3ncc(cn3)[C@@](C)(N)c3ccc(F)cc3)c(cnn2c1)C#N
Show InChI InChI=1S/C28H27FN10/c1-28(31,22-3-5-24(29)6-4-22)23-15-32-27(33-16-23)38-9-7-37(8-10-38)26-20(12-30)13-35-39-18-19(11-25(26)39)21-14-34-36(2)17-21/h3-6,11,13-18H,7-10,31H2,1-2H3/t28-/m0/s1
PDB

GoogleScholar
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...


US Patent US11040979 (2021)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (V559D/T670I)


(Homo sapiens (Human))
BDBM504399
PNG
((S)-1-(2-(4-(3-chloro-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES Cn1cc(cn1)-c1cc2c(N3CCN(CC3)c3ncc(cn3)[C@@](C)(N)c3ccc(F)cc3)c(Cl)cnn2c1
Show InChI InChI=1S/C27H27ClFN9/c1-27(30,20-3-5-22(29)6-4-20)21-13-31-26(32-14-21)37-9-7-36(8-10-37)25-23(28)15-34-38-17-18(11-24(25)38)19-12-33-35(2)16-19/h3-6,11-17H,7-10,30H2,1-2H3/t27-/m0/s1
MMDB

GoogleScholar
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...


US Patent US11040979 (2021)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (V560G)


(Mast/stem cell growth factor receptor Kit)
BDBM504400
PNG
((S)-4-(4-(5-(1-amino-1-(4-fluorophenyl)ethyl)pyrim...)
Show SMILES Cn1cc(cn1)-c1cc2c(N3CCN(CC3)c3ncc(cn3)[C@@](C)(N)c3ccc(F)cc3)c(cnn2c1)C#N
Show InChI InChI=1S/C28H27FN10/c1-28(31,22-3-5-24(29)6-4-22)23-15-32-27(33-16-23)38-9-7-37(8-10-38)26-20(12-30)13-35-39-18-19(11-25(26)39)21-14-34-36(2)17-21/h3-6,11,13-18H,7-10,31H2,1-2H3/t28-/m0/s1
MMDB

KEGG

DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...


US Patent US11040979 (2021)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (V559D/T670I)


(Homo sapiens (Human))
BDBM504397
PNG
((S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyr...)
Show SMILES Cn1cc(cn1)-c1cc2c(ccnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1
Show InChI InChI=1S/C27H28FN9/c1-27(29,21-3-5-23(28)6-4-21)22-15-30-26(31-16-22)36-11-9-35(10-12-36)24-7-8-32-37-18-19(13-25(24)37)20-14-33-34(2)17-20/h3-8,13-18H,9-12,29H2,1-2H3/t27-/m0/s1
MMDB

GoogleScholar
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...


US Patent US11040979 (2021)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (V559D/V654A)


(Homo sapiens (Human))
BDBM504397
PNG
((S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyr...)
Show SMILES Cn1cc(cn1)-c1cc2c(ccnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1
Show InChI InChI=1S/C27H28FN9/c1-27(29,21-3-5-23(28)6-4-21)22-15-30-26(31-16-22)36-11-9-35(10-12-36)24-7-8-32-37-18-19(13-25(24)37)20-14-33-34(2)17-20/h3-8,13-18H,9-12,29H2,1-2H3/t27-/m0/s1
GoogleScholar
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...


US Patent US11040979 (2021)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (V559D/T670I)


(Homo sapiens (Human))
BDBM504398
PNG
((S)-1-(2-(4-(3-fluoro-6-(1-methyl-11H-pyrazol-4-yl...)
Show SMILES Cn1cc(cn1)-c1cc2c(N3CCN(CC3)c3ncc(cn3)[C@@](C)(N)c3ccc(F)cc3)c(F)cnn2c1
Show InChI InChI=1S/C27H27F2N9/c1-27(30,20-3-5-22(28)6-4-20)21-13-31-26(32-14-21)37-9-7-36(8-10-37)25-23(29)15-34-38-17-18(11-24(25)38)19-12-33-35(2)16-19/h3-6,11-17H,7-10,30H2,1-2H3/t27-/m0/s1
MMDB

GoogleScholar
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...


US Patent US11040979 (2021)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (V559D/T670I)


(Homo sapiens (Human))
BDBM504400
PNG
((S)-4-(4-(5-(1-amino-1-(4-fluorophenyl)ethyl)pyrim...)
Show SMILES Cn1cc(cn1)-c1cc2c(N3CCN(CC3)c3ncc(cn3)[C@@](C)(N)c3ccc(F)cc3)c(cnn2c1)C#N
Show InChI InChI=1S/C28H27FN10/c1-28(31,22-3-5-24(29)6-4-22)23-15-32-27(33-16-23)38-9-7-37(8-10-38)26-20(12-30)13-35-39-18-19(11-25(26)39)21-14-34-36(2)17-21/h3-6,11,13-18H,7-10,31H2,1-2H3/t28-/m0/s1
MMDB

GoogleScholar
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...


US Patent US11040979 (2021)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (V560G)


(Mast/stem cell growth factor receptor Kit)
BDBM504397
PNG
((S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyr...)
Show SMILES Cn1cc(cn1)-c1cc2c(ccnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1
Show InChI InChI=1S/C27H28FN9/c1-27(29,21-3-5-23(28)6-4-21)22-15-30-26(31-16-22)36-11-9-35(10-12-36)24-7-8-32-37-18-19(13-25(24)37)20-14-33-34(2)17-20/h3-8,13-18H,9-12,29H2,1-2H3/t27-/m0/s1
MMDB

KEGG

DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...


US Patent US11040979 (2021)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (V560G)


(Mast/stem cell growth factor receptor Kit)
BDBM504399
PNG
((S)-1-(2-(4-(3-chloro-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES Cn1cc(cn1)-c1cc2c(N3CCN(CC3)c3ncc(cn3)[C@@](C)(N)c3ccc(F)cc3)c(Cl)cnn2c1
Show InChI InChI=1S/C27H27ClFN9/c1-27(30,20-3-5-22(29)6-4-20)21-13-31-26(32-14-21)37-9-7-36(8-10-37)25-23(28)15-34-38-17-18(11-24(25)38)19-12-33-35(2)16-19/h3-6,11-17H,7-10,30H2,1-2H3/t27-/m0/s1
MMDB

KEGG

DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...


US Patent US11040979 (2021)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (V559D/V654A)


(Homo sapiens (Human))
BDBM504398
PNG
((S)-1-(2-(4-(3-fluoro-6-(1-methyl-11H-pyrazol-4-yl...)
Show SMILES Cn1cc(cn1)-c1cc2c(N3CCN(CC3)c3ncc(cn3)[C@@](C)(N)c3ccc(F)cc3)c(F)cnn2c1
Show InChI InChI=1S/C27H27F2N9/c1-27(30,20-3-5-22(28)6-4-20)21-13-31-26(32-14-21)37-9-7-36(8-10-37)25-23(29)15-34-38-17-18(11-24(25)38)19-12-33-35(2)16-19/h3-6,11-17H,7-10,30H2,1-2H3/t27-/m0/s1
GoogleScholar
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...


US Patent US11040979 (2021)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (V559D/V654A)


(Homo sapiens (Human))
BDBM504400
PNG
((S)-4-(4-(5-(1-amino-1-(4-fluorophenyl)ethyl)pyrim...)
Show SMILES Cn1cc(cn1)-c1cc2c(N3CCN(CC3)c3ncc(cn3)[C@@](C)(N)c3ccc(F)cc3)c(cnn2c1)C#N
Show InChI InChI=1S/C28H27FN10/c1-28(31,22-3-5-24(29)6-4-22)23-15-32-27(33-16-23)38-9-7-37(8-10-38)26-20(12-30)13-35-39-18-19(11-25(26)39)21-14-34-36(2)17-21/h3-6,11,13-18H,7-10,31H2,1-2H3/t28-/m0/s1
GoogleScholar
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...


US Patent US11040979 (2021)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (V560G)


(Mast/stem cell growth factor receptor Kit)
BDBM504398
PNG
((S)-1-(2-(4-(3-fluoro-6-(1-methyl-11H-pyrazol-4-yl...)
Show SMILES Cn1cc(cn1)-c1cc2c(N3CCN(CC3)c3ncc(cn3)[C@@](C)(N)c3ccc(F)cc3)c(F)cnn2c1
Show InChI InChI=1S/C27H27F2N9/c1-27(30,20-3-5-22(28)6-4-20)21-13-31-26(32-14-21)37-9-7-36(8-10-37)25-23(29)15-34-38-17-18(11-24(25)38)19-12-33-35(2)16-19/h3-6,11-17H,7-10,30H2,1-2H3/t27-/m0/s1
MMDB

KEGG

DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...


US Patent US11040979 (2021)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (V559D/V654A)


(Homo sapiens (Human))
BDBM504399
PNG
((S)-1-(2-(4-(3-chloro-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES Cn1cc(cn1)-c1cc2c(N3CCN(CC3)c3ncc(cn3)[C@@](C)(N)c3ccc(F)cc3)c(Cl)cnn2c1
Show InChI InChI=1S/C27H27ClFN9/c1-27(30,20-3-5-22(29)6-4-20)21-13-31-26(32-14-21)37-9-7-36(8-10-37)25-23(28)15-34-38-17-18(11-24(25)38)19-12-33-35(2)16-19/h3-6,11-17H,7-10,30H2,1-2H3/t27-/m0/s1
GoogleScholar
UniChem
US Patent
n/an/a>100n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...


US Patent US11040979 (2021)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM504398
PNG
((S)-1-(2-(4-(3-fluoro-6-(1-methyl-11H-pyrazol-4-yl...)
Show SMILES Cn1cc(cn1)-c1cc2c(N3CCN(CC3)c3ncc(cn3)[C@@](C)(N)c3ccc(F)cc3)c(F)cnn2c1
Show InChI InChI=1S/C27H27F2N9/c1-27(30,20-3-5-22(28)6-4-20)21-13-31-26(32-14-21)37-9-7-36(8-10-37)25-23(29)15-34-38-17-18(11-24(25)38)19-12-33-35(2)16-19/h3-6,11-17H,7-10,30H2,1-2H3/t27-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a>100n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...


US Patent US11040979 (2021)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM504400
PNG
((S)-4-(4-(5-(1-amino-1-(4-fluorophenyl)ethyl)pyrim...)
Show SMILES Cn1cc(cn1)-c1cc2c(N3CCN(CC3)c3ncc(cn3)[C@@](C)(N)c3ccc(F)cc3)c(cnn2c1)C#N
Show InChI InChI=1S/C28H27FN10/c1-28(31,22-3-5-24(29)6-4-22)23-15-32-27(33-16-23)38-9-7-37(8-10-38)26-20(12-30)13-35-39-18-19(11-25(26)39)21-14-34-36(2)17-21/h3-6,11,13-18H,7-10,31H2,1-2H3/t28-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a>100n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...


US Patent US11040979 (2021)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM504399
PNG
((S)-1-(2-(4-(3-chloro-6-(1-methyl-1H-pyrazol-4-yl)...)
Show SMILES Cn1cc(cn1)-c1cc2c(N3CCN(CC3)c3ncc(cn3)[C@@](C)(N)c3ccc(F)cc3)c(Cl)cnn2c1
Show InChI InChI=1S/C27H27ClFN9/c1-27(30,20-3-5-22(29)6-4-20)21-13-31-26(32-14-21)37-9-7-36(8-10-37)25-23(28)15-34-38-17-18(11-24(25)38)19-12-33-35(2)16-19/h3-6,11-17H,7-10,30H2,1-2H3/t27-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a>100n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...


US Patent US11040979 (2021)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM504397
PNG
((S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyr...)
Show SMILES Cn1cc(cn1)-c1cc2c(ccnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1
Show InChI InChI=1S/C27H28FN9/c1-27(29,21-3-5-23(28)6-4-21)22-15-30-26(31-16-22)36-11-9-35(10-12-36)24-7-8-32-37-18-19(13-25(24)37)20-14-33-34(2)17-20/h3-8,13-18H,9-12,29H2,1-2H3/t27-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a>100n/an/an/an/an/an/a



Blueprint Medicines Corporation

US Patent


Assay Description
KIT, KIT mutant, and PDGFRα mutant kinase profiling was performed with recombinant enzymes including wild-type KIT, KIT V560G, KIT V559D/T670I, ...


US Patent US11040979 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%