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Patent code US11045455

Compile Data Set for Download or QSAR
Found 135 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506358
PNG
(US11045455, Compound 2)
Show SMILES CS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C17H15N7O2S/c1-27(25,26)23-10-17(11-23,3-4-18)24-9-13(8-22-24)15-12(6-19)7-21-16-14(15)2-5-20-16/h2,5,7-9H,3,10-11H2,1H3,(H,20,21)
PDB

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n/an/a 0.170n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506397
PNG
(US11045455, Compound 52 | US11045455, Compound 52-...)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(F)cnc2[nH]ccc12
Show InChI InChI=1S/C17H17FN6O2S/c1-2-27(25,26)23-10-17(11-23,4-5-19)24-9-12(7-22-24)15-13-3-6-20-16(13)21-8-14(15)18/h3,6-9H,2,4,10-11H2,1H3,(H,20,21)
PDB

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n/an/a 0.350n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506380
PNG
(US11045455, Compound 26)
Show SMILES O=S(=O)(C1CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C18H18N6O2S/c19-6-5-18(11-23(12-18)27(25,26)14-1-2-14)24-10-13(9-22-24)15-3-7-20-17-16(15)4-8-21-17/h3-4,7-10,14H,1-2,5,11-12H2,(H,20,21)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506397
PNG
(US11045455, Compound 52 | US11045455, Compound 52-...)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(F)cnc2[nH]ccc12
Show InChI InChI=1S/C17H17FN6O2S/c1-2-27(25,26)23-10-17(11-23,4-5-19)24-9-12(7-22-24)15-13-3-6-20-16(13)21-8-14(15)18/h3,6-9H,2,4,10-11H2,1H3,(H,20,21)
PDB

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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506397
PNG
(US11045455, Compound 52 | US11045455, Compound 52-...)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(F)cnc2[nH]ccc12
Show InChI InChI=1S/C17H17FN6O2S/c1-2-27(25,26)23-10-17(11-23,4-5-19)24-9-12(7-22-24)15-13-3-6-20-16(13)21-8-14(15)18/h3,6-9H,2,4,10-11H2,1H3,(H,20,21)
PDB

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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506377
PNG
(US11045455, Compound 19)
Show SMILES CS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C16H16N6O2S/c1-25(23,24)21-10-16(11-21,4-5-17)22-9-12(8-20-22)13-2-6-18-15-14(13)3-7-19-15/h2-3,6-9H,4,10-11H2,1H3,(H,18,19)
PDB

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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506358
PNG
(US11045455, Compound 2)
Show SMILES CS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C17H15N7O2S/c1-27(25,26)23-10-17(11-23,3-4-18)24-9-13(8-22-24)15-12(6-19)7-21-16-14(15)2-5-20-16/h2,5,7-9H,3,10-11H2,1H3,(H,20,21)
PDB

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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506380
PNG
(US11045455, Compound 26)
Show SMILES O=S(=O)(C1CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C18H18N6O2S/c19-6-5-18(11-23(12-18)27(25,26)14-1-2-14)24-10-13(9-22-24)15-3-7-20-17-16(15)4-8-21-17/h3-4,7-10,14H,1-2,5,11-12H2,(H,20,21)
PDB

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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506375
PNG
(US11045455, Compound 14)
Show SMILES CN(C)S(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C17H19N7O2S/c1-22(2)27(25,26)23-11-17(12-23,5-6-18)24-10-13(9-21-24)14-3-7-19-16-15(14)4-8-20-16/h3-4,7-10H,5,11-12H2,1-2H3,(H,19,20)
PDB

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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506396
PNG
(US11045455, Compound 50 | US11045455, Compound 50-...)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(Cl)cnc2[nH]ccc12
Show InChI InChI=1S/C17H17ClN6O2S/c1-2-27(25,26)23-10-17(11-23,4-5-19)24-9-12(7-22-24)15-13-3-6-20-16(13)21-8-14(15)18/h3,6-9H,2,4,10-11H2,1H3,(H,20,21)
PDB

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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506397
PNG
(US11045455, Compound 52 | US11045455, Compound 52-...)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(F)cnc2[nH]ccc12
Show InChI InChI=1S/C17H17FN6O2S/c1-2-27(25,26)23-10-17(11-23,4-5-19)24-9-12(7-22-24)15-13-3-6-20-16(13)21-8-14(15)18/h3,6-9H,2,4,10-11H2,1H3,(H,20,21)
PDB

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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506386
PNG
(US11045455, Compound 43)
Show SMILES CC(C)S(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C19H19N7O2S/c1-13(2)29(27,28)25-11-19(12-25,4-5-20)26-10-15(9-24-26)17-14(7-21)8-23-18-16(17)3-6-22-18/h3,6,8-10,13H,4,11-12H2,1-2H3,(H,22,23)
PDB

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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506396
PNG
(US11045455, Compound 50 | US11045455, Compound 50-...)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(Cl)cnc2[nH]ccc12
Show InChI InChI=1S/C17H17ClN6O2S/c1-2-27(25,26)23-10-17(11-23,4-5-19)24-9-12(7-22-24)15-13-3-6-20-16(13)21-8-14(15)18/h3,6-9H,2,4,10-11H2,1H3,(H,20,21)
PDB

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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506396
PNG
(US11045455, Compound 50 | US11045455, Compound 50-...)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(Cl)cnc2[nH]ccc12
Show InChI InChI=1S/C17H17ClN6O2S/c1-2-27(25,26)23-10-17(11-23,4-5-19)24-9-12(7-22-24)15-13-3-6-20-16(13)21-8-14(15)18/h3,6-9H,2,4,10-11H2,1H3,(H,20,21)
PDB

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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506393
PNG
(US11045455, Compound 39)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cc1C#N)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H17N7O2S/c1-2-28(26,27)24-10-18(11-24,4-5-19)25-9-13(7-14(25)8-20)16-15-3-6-21-17(15)23-12-22-16/h3,6-7,9,12H,2,4,10-11H2,1H3,(H,21,22,23)
PDB

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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506377
PNG
(US11045455, Compound 19)
Show SMILES CS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C16H16N6O2S/c1-25(23,24)21-10-16(11-21,4-5-17)22-9-12(8-20-22)13-2-6-18-15-14(13)3-7-19-15/h2-3,6-9H,4,10-11H2,1H3,(H,18,19)
PDB

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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506363
PNG
(US11045455, Compound 5)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C18H17N7O2S/c1-2-28(26,27)24-11-18(12-24,4-5-19)25-10-14(9-23-25)16-13(7-20)8-22-17-15(16)3-6-21-17/h3,6,8-10H,2,4,11-12H2,1H3,(H,21,22)
PDB

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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506382
PNG
(US11045455, Compound 31)
Show SMILES CC1(CC1)S(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C19H20N6O2S/c1-18(4-5-18)28(26,27)24-12-19(13-24,6-7-20)25-11-14(10-23-25)15-2-8-21-17-16(15)3-9-22-17/h2-3,8-11H,4-6,12-13H2,1H3,(H,21,22)
PDB

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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506348
PNG
(US11045455, Compound 1)
Show SMILES CC1(CC1)S(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C20H19N7O2S/c1-19(3-4-19)30(28,29)26-12-20(13-26,5-6-21)27-11-15(10-25-27)17-14(8-22)9-24-18-16(17)2-7-23-18/h2,7,9-11H,3-5,12-13H2,1H3,(H,23,24)
PDB

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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506383
PNG
(US11045455, Compound 34)
Show SMILES CN(C)S(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C18H18N8O2S/c1-24(2)29(27,28)25-11-18(12-25,4-5-19)26-10-14(9-23-26)16-13(7-20)8-22-17-15(16)3-6-21-17/h3,6,8-10H,4,11-12H2,1-2H3,(H,21,22)
PDB

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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506374
PNG
(US11045455, Compound 8)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C17H18N6O2S/c1-2-26(24,25)22-11-17(12-22,5-6-18)23-10-13(9-21-23)14-3-7-19-16-15(14)4-8-20-16/h3-4,7-10H,2,5,11-12H2,1H3,(H,19,20)
PDB

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n/an/a 0.820n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506379
PNG
(US11045455, Compound 25)
Show SMILES CC(C)CS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C19H22N6O2S/c1-14(2)11-28(26,27)24-12-19(13-24,5-6-20)25-10-15(9-23-25)16-3-7-21-18-17(16)4-8-22-18/h3-4,7-10,14H,5,11-13H2,1-2H3,(H,21,22)
PDB

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n/an/a 0.830n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506385
PNG
(US11045455, Compound 12-2)
Show SMILES CCS(=O)(=O)N1CC(C1)(C(C)C#N)n1cc(cn1)-c1ncnc2[nH]ccc12
PDB

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n/an/a 0.860n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506393
PNG
(US11045455, Compound 39)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cc1C#N)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H17N7O2S/c1-2-28(26,27)24-10-18(11-24,4-5-19)25-9-13(7-14(25)8-20)16-15-3-6-21-17(15)23-12-22-16/h3,6-7,9,12H,2,4,10-11H2,1H3,(H,21,22,23)
PDB

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n/an/a 0.870n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506378
PNG
(US11045455, Compound 23)
Show SMILES CCCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C18H20N6O2S/c1-2-9-27(25,26)23-12-18(13-23,5-6-19)24-11-14(10-22-24)15-3-7-20-17-16(15)4-8-21-17/h3-4,7-8,10-11H,2,5,9,12-13H2,1H3,(H,20,21)
PDB

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n/an/a 0.890n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506376
PNG
(US11045455, Compound 17)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1ccc(c1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C19H18N6O2S/c1-2-28(26,27)25-12-19(13-25,5-6-20)24-8-4-14(11-24)17-15(9-21)10-23-18-16(17)3-7-22-18/h3-4,7-8,10-11H,2,5,12-13H2,1H3,(H,22,23)
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n/an/a 0.930n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506384
PNG
(US11045455, Compound 40)
Show SMILES CCCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C19H19N7O2S/c1-2-7-29(27,28)25-12-19(13-25,4-5-20)26-11-15(10-24-26)17-14(8-21)9-23-18-16(17)3-6-22-18/h3,6,9-11H,2,4,7,12-13H2,1H3,(H,22,23)
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n/an/a 0.970n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506374
PNG
(US11045455, Compound 8)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C17H18N6O2S/c1-2-26(24,25)22-11-17(12-22,5-6-18)23-10-13(9-21-23)14-3-7-19-16-15(14)4-8-20-16/h3-4,7-10H,2,5,11-12H2,1H3,(H,19,20)
PDB

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n/an/a 1.05n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506388
PNG
(US11045455, Compound 45 | US11045455, Compound 45-...)
Show SMILES CCS(=O)(=O)N1CC(C1)(C(C)C#N)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
PDB

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n/an/a 1.11n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506376
PNG
(US11045455, Compound 17)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1ccc(c1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C19H18N6O2S/c1-2-28(26,27)25-12-19(13-25,5-6-20)24-8-4-14(11-24)17-15(9-21)10-23-18-16(17)3-7-22-18/h3-4,7-8,10-11H,2,5,12-13H2,1H3,(H,22,23)
PDB

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n/an/a 1.13n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506396
PNG
(US11045455, Compound 50 | US11045455, Compound 50-...)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(Cl)cnc2[nH]ccc12
Show InChI InChI=1S/C17H17ClN6O2S/c1-2-27(25,26)23-10-17(11-23,4-5-19)24-9-12(7-22-24)15-13-3-6-20-16(13)21-8-14(15)18/h3,6-9H,2,4,10-11H2,1H3,(H,20,21)
PDB

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n/an/a 1.14n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506388
PNG
(US11045455, Compound 45 | US11045455, Compound 45-...)
Show SMILES CCS(=O)(=O)N1CC(C1)(C(C)C#N)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
PDB

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n/an/a 1.17n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506395
PNG
(US11045455, Compound 49)
Show SMILES CC(C)S(=O)(=O)N1CC(CC#N)(C1)n1cc(c(C)n1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H21N7O2S/c1-12(2)28(26,27)24-9-18(10-24,5-6-19)25-8-15(13(3)23-25)16-14-4-7-20-17(14)22-11-21-16/h4,7-8,11-12H,5,9-10H2,1-3H3,(H,20,21,22)
PDB

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n/an/a 1.21n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506382
PNG
(US11045455, Compound 31)
Show SMILES CC1(CC1)S(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C19H20N6O2S/c1-18(4-5-18)28(26,27)24-12-19(13-24,6-7-20)25-11-14(10-23-25)15-2-8-21-17-16(15)3-9-22-17/h2-3,8-11H,4-6,12-13H2,1H3,(H,21,22)
PDB

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n/an/a 1.23n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506375
PNG
(US11045455, Compound 14)
Show SMILES CN(C)S(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C17H19N7O2S/c1-22(2)27(25,26)23-11-17(12-23,5-6-18)24-10-13(9-21-24)14-3-7-19-16-15(14)4-8-20-16/h3-4,7-10H,5,11-12H2,1-2H3,(H,19,20)
PDB

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n/an/a 1.30n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506390
PNG
(US11045455, Compound 35)
Show SMILES O=S(=O)(N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12)N1CCCC1
Show InChI InChI=1S/C19H21N7O2S/c20-6-5-19(13-25(14-19)29(27,28)24-9-1-2-10-24)26-12-15(11-23-26)16-3-7-21-18-17(16)4-8-22-18/h3-4,7-8,11-12H,1-2,5,9-10,13-14H2,(H,21,22)
PDB

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n/an/a 1.40n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506394
PNG
(US11045455, Compound 48)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(c(Cl)n1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C17H17ClN6O2S/c1-2-27(25,26)23-10-17(11-23,5-6-19)24-9-14(15(18)22-24)12-3-7-20-16-13(12)4-8-21-16/h3-4,7-9H,2,5,10-11H2,1H3,(H,20,21)
PDB

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n/an/a 1.40n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506389
PNG
(US11045455, Compound 13)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(c(C)n1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C18H20N6O2S/c1-3-27(25,26)23-11-18(12-23,6-7-19)24-10-16(13(2)22-24)14-4-8-20-17-15(14)5-9-21-17/h4-5,8-10H,3,6,11-12H2,1-2H3,(H,20,21)
PDB

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n/an/a 1.44n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506390
PNG
(US11045455, Compound 35)
Show SMILES O=S(=O)(N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12)N1CCCC1
Show InChI InChI=1S/C19H21N7O2S/c20-6-5-19(13-25(14-19)29(27,28)24-9-1-2-10-24)26-12-15(11-23-26)16-3-7-21-18-17(16)4-8-22-18/h3-4,7-8,11-12H,1-2,5,9-10,13-14H2,(H,21,22)
PDB

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n/an/a 1.46n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506363
PNG
(US11045455, Compound 5)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C18H17N7O2S/c1-2-28(26,27)24-11-18(12-24,4-5-19)25-10-14(9-23-25)16-13(7-20)8-22-17-15(16)3-6-21-17/h3,6,8-10H,2,4,11-12H2,1H3,(H,21,22)
PDB

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n/an/a 1.49n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506395
PNG
(US11045455, Compound 49)
Show SMILES CC(C)S(=O)(=O)N1CC(CC#N)(C1)n1cc(c(C)n1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H21N7O2S/c1-12(2)28(26,27)24-9-18(10-24,5-6-19)25-8-15(13(3)23-25)16-14-4-7-20-17(14)22-11-21-16/h4,7-8,11-12H,5,9-10H2,1-3H3,(H,20,21,22)
PDB

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n/an/a 1.63n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506388
PNG
(US11045455, Compound 45 | US11045455, Compound 45-...)
Show SMILES CCS(=O)(=O)N1CC(C1)(C(C)C#N)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
PDB

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n/an/a 1.65n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506383
PNG
(US11045455, Compound 34)
Show SMILES CN(C)S(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C18H18N8O2S/c1-24(2)29(27,28)25-11-18(12-25,4-5-19)26-10-14(9-23-26)16-13(7-20)8-22-17-15(16)3-6-21-17/h3,6,8-10H,4,11-12H2,1-2H3,(H,21,22)
PDB

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n/an/a 1.66n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506388
PNG
(US11045455, Compound 45 | US11045455, Compound 45-...)
Show SMILES CCS(=O)(=O)N1CC(C1)(C(C)C#N)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
PDB

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n/an/a 1.66n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506398
PNG
(US11045455, Compound 56)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(C)c(c1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H20N6O2S/c1-3-27(25,26)24-10-18(11-24,5-6-19)23-8-13(2)15(9-23)16-14-4-7-20-17(14)22-12-21-16/h4,7-9,12H,3,5,10-11H2,1-2H3,(H,20,21,22)
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n/an/a 1.76n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506385
PNG
(US11045455, Compound 12-2)
Show SMILES CCS(=O)(=O)N1CC(C1)(C(C)C#N)n1cc(cn1)-c1ncnc2[nH]ccc12
PDB

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n/an/a 1.81n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506388
PNG
(US11045455, Compound 45 | US11045455, Compound 45-...)
Show SMILES CCS(=O)(=O)N1CC(C1)(C(C)C#N)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
PDB

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n/an/a 1.85n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506387
PNG
(US11045455, Compound 44)
Show SMILES FC(F)(F)CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C19H16F3N7O2S/c20-19(21,22)3-6-32(30,31)28-11-18(12-28,2-4-23)29-10-14(9-27-29)16-13(7-24)8-26-17-15(16)1-5-25-17/h1,5,8-10H,2-3,6,11-12H2,(H,25,26)
PDB

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n/an/a 1.95n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506348
PNG
(US11045455, Compound 1)
Show SMILES CC1(CC1)S(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C20H19N7O2S/c1-19(3-4-19)30(28,29)26-12-20(13-26,5-6-21)27-11-15(10-25-27)17-14(8-22)9-24-18-16(17)2-7-23-18/h2,7,9-11H,3-5,12-13H2,1H3,(H,23,24)
PDB

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n/an/a 1.98n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506381
PNG
(US11045455, Compound 30)
Show SMILES FC(F)(F)CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C18H17F3N6O2S/c19-18(20,21)4-8-30(28,29)26-11-17(12-26,3-5-22)27-10-13(9-25-27)14-1-6-23-16-15(14)2-7-24-16/h1-2,6-7,9-10H,3-4,8,11-12H2,(H,23,24)
PDB

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n/an/a 2.16n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506381
PNG
(US11045455, Compound 30)
Show SMILES FC(F)(F)CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C18H17F3N6O2S/c19-18(20,21)4-8-30(28,29)26-11-17(12-26,3-5-22)27-10-13(9-25-27)14-1-6-23-16-15(14)2-7-24-16/h1-2,6-7,9-10H,3-4,8,11-12H2,(H,23,24)
PDB

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n/an/a 2.22n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506384
PNG
(US11045455, Compound 40)
Show SMILES CCCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C19H19N7O2S/c1-2-7-29(27,28)25-12-19(13-25,4-5-20)26-11-15(10-24-26)17-14(8-21)9-23-18-16(17)3-6-22-18/h3,6,9-11H,2,4,7,12-13H2,1H3,(H,22,23)
PDB

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n/an/a 2.24n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506379
PNG
(US11045455, Compound 25)
Show SMILES CC(C)CS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C19H22N6O2S/c1-14(2)11-28(26,27)24-12-19(13-24,5-6-20)25-10-15(9-23-25)16-3-7-21-18-17(16)4-8-22-18/h3-4,7-10,14H,5,11-13H2,1-2H3,(H,21,22)
PDB

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n/an/a 2.29n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506378
PNG
(US11045455, Compound 23)
Show SMILES CCCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C18H20N6O2S/c1-2-9-27(25,26)23-12-18(13-23,5-6-19)24-11-14(10-22-24)15-3-7-20-17-16(15)4-8-21-17/h3-4,7-8,10-11H,2,5,9,12-13H2,1H3,(H,20,21)
PDB

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n/an/a 2.41n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506386
PNG
(US11045455, Compound 43)
Show SMILES CC(C)S(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C19H19N7O2S/c1-13(2)29(27,28)25-11-19(12-25,4-5-20)26-10-15(9-24-26)17-14(7-21)8-23-18-16(17)3-6-22-18/h3,6,8-10,13H,4,11-12H2,1-2H3,(H,22,23)
PDB

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n/an/a 2.54n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506389
PNG
(US11045455, Compound 13)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(c(C)n1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C18H20N6O2S/c1-3-27(25,26)23-11-18(12-23,6-7-19)24-10-16(13(2)22-24)14-4-8-20-17-15(14)5-9-21-17/h4-5,8-10H,3,6,11-12H2,1-2H3,(H,20,21)
PDB

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n/an/a 2.89n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506388
PNG
(US11045455, Compound 45 | US11045455, Compound 45-...)
Show SMILES CCS(=O)(=O)N1CC(C1)(C(C)C#N)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
PDB

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n/an/a 3.22n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506398
PNG
(US11045455, Compound 56)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(C)c(c1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H20N6O2S/c1-3-27(25,26)24-10-18(11-24,5-6-19)23-8-13(2)15(9-23)16-14-4-7-20-17(14)22-12-21-16/h4,7-9,12H,3,5,10-11H2,1-2H3,(H,20,21,22)
PDB

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n/an/a 3.52n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM506387
PNG
(US11045455, Compound 44)
Show SMILES FC(F)(F)CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C19H16F3N7O2S/c20-19(21,22)3-6-32(30,31)28-11-18(12-28,2-4-23)29-10-14(9-27-29)16-13(7-24)8-26-17-15(16)1-5-25-17/h1,5,8-10H,2-3,6,11-12H2,(H,25,26)
PDB

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n/an/a 3.93n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM506394
PNG
(US11045455, Compound 48)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(c(Cl)n1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C17H17ClN6O2S/c1-2-27(25,26)23-10-17(11-23,5-6-19)24-9-14(15(18)22-24)12-3-7-20-16-13(12)4-8-21-16/h3-4,7-9H,2,5,10-11H2,1H3,(H,20,21)
PDB

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n/an/a 5.66n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM506377
PNG
(US11045455, Compound 19)
Show SMILES CS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C16H16N6O2S/c1-25(23,24)21-10-16(11-21,4-5-17)22-9-12(8-20-22)13-2-6-18-15-14(13)3-7-19-15/h2-3,6-9H,4,10-11H2,1H3,(H,18,19)
PDB

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n/an/a 10.3n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM506385
PNG
(US11045455, Compound 12-2)
Show SMILES CCS(=O)(=O)N1CC(C1)(C(C)C#N)n1cc(cn1)-c1ncnc2[nH]ccc12
PDB

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n/an/a 20n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM506388
PNG
(US11045455, Compound 45 | US11045455, Compound 45-...)
Show SMILES CCS(=O)(=O)N1CC(C1)(C(C)C#N)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
PDB

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n/an/a 20n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM506393
PNG
(US11045455, Compound 39)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cc1C#N)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H17N7O2S/c1-2-28(26,27)24-10-18(11-24,4-5-19)25-9-13(7-14(25)8-20)16-15-3-6-21-17(15)23-12-22-16/h3,6-7,9,12H,2,4,10-11H2,1H3,(H,21,22,23)
PDB

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n/an/a 20n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM506388
PNG
(US11045455, Compound 45 | US11045455, Compound 45-...)
Show SMILES CCS(=O)(=O)N1CC(C1)(C(C)C#N)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
PDB

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n/an/a 20n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM506386
PNG
(US11045455, Compound 43)
Show SMILES CC(C)S(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C19H19N7O2S/c1-13(2)29(27,28)25-11-19(12-25,4-5-20)26-10-15(9-24-26)17-14(7-21)8-23-18-16(17)3-6-22-18/h3,6,8-10,13H,4,11-12H2,1-2H3,(H,22,23)
PDB

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n/an/a 20n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM506382
PNG
(US11045455, Compound 31)
Show SMILES CC1(CC1)S(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C19H20N6O2S/c1-18(4-5-18)28(26,27)24-12-19(13-24,6-7-20)25-11-14(10-23-25)15-2-8-21-17-16(15)3-9-22-17/h2-3,8-11H,4-6,12-13H2,1H3,(H,21,22)
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n/an/a 23.6n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM506363
PNG
(US11045455, Compound 5)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C18H17N7O2S/c1-2-28(26,27)24-11-18(12-24,4-5-19)25-10-14(9-23-25)16-13(7-20)8-22-17-15(16)3-6-21-17/h3,6,8-10H,2,4,11-12H2,1H3,(H,21,22)
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n/an/a 27n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM506374
PNG
(US11045455, Compound 8)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C17H18N6O2S/c1-2-26(24,25)22-11-17(12-22,5-6-18)23-10-13(9-21-23)14-3-7-19-16-15(14)4-8-20-16/h3-4,7-10H,2,5,11-12H2,1H3,(H,19,20)
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n/an/a 27.3n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM506388
PNG
(US11045455, Compound 45 | US11045455, Compound 45-...)
Show SMILES CCS(=O)(=O)N1CC(C1)(C(C)C#N)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
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n/an/a 30n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM506385
PNG
(US11045455, Compound 12-2)
Show SMILES CCS(=O)(=O)N1CC(C1)(C(C)C#N)n1cc(cn1)-c1ncnc2[nH]ccc12
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n/an/a 30n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM506379
PNG
(US11045455, Compound 25)
Show SMILES CC(C)CS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C19H22N6O2S/c1-14(2)11-28(26,27)24-12-19(13-24,5-6-20)25-10-15(9-23-25)16-3-7-21-18-17(16)4-8-22-18/h3-4,7-10,14H,5,11-13H2,1-2H3,(H,21,22)
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n/an/a>30n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM506386
PNG
(US11045455, Compound 43)
Show SMILES CC(C)S(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C19H19N7O2S/c1-13(2)29(27,28)25-11-19(12-25,4-5-20)26-10-15(9-24-26)17-14(7-21)8-23-18-16(17)3-6-22-18/h3,6,8-10,13H,4,11-12H2,1-2H3,(H,22,23)
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n/an/a>30n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM506389
PNG
(US11045455, Compound 13)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(c(C)n1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C18H20N6O2S/c1-3-27(25,26)23-11-18(12-23,6-7-19)24-10-16(13(2)22-24)14-4-8-20-17-15(14)5-9-21-17/h4-5,8-10H,3,6,11-12H2,1-2H3,(H,20,21)
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n/an/a 30n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM506379
PNG
(US11045455, Compound 25)
Show SMILES CC(C)CS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C19H22N6O2S/c1-14(2)11-28(26,27)24-12-19(13-24,5-6-20)25-10-15(9-23-25)16-3-7-21-18-17(16)4-8-22-18/h3-4,7-10,14H,5,11-13H2,1-2H3,(H,21,22)
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n/an/a>30n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM506389
PNG
(US11045455, Compound 13)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(c(C)n1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C18H20N6O2S/c1-3-27(25,26)23-11-18(12-23,6-7-19)24-10-16(13(2)22-24)14-4-8-20-17-15(14)5-9-21-17/h4-5,8-10H,3,6,11-12H2,1-2H3,(H,20,21)
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n/an/a>30n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM506390
PNG
(US11045455, Compound 35)
Show SMILES O=S(=O)(N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12)N1CCCC1
Show InChI InChI=1S/C19H21N7O2S/c20-6-5-19(13-25(14-19)29(27,28)24-9-1-2-10-24)26-12-15(11-23-26)16-3-7-21-18-17(16)4-8-22-18/h3-4,7-8,11-12H,1-2,5,9-10,13-14H2,(H,21,22)
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n/an/a>30n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM506388
PNG
(US11045455, Compound 45 | US11045455, Compound 45-...)
Show SMILES CCS(=O)(=O)N1CC(C1)(C(C)C#N)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
PDB

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n/an/a 30n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM506390
PNG
(US11045455, Compound 35)
Show SMILES O=S(=O)(N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12)N1CCCC1
Show InChI InChI=1S/C19H21N7O2S/c20-6-5-19(13-25(14-19)29(27,28)24-9-1-2-10-24)26-12-15(11-23-26)16-3-7-21-18-17(16)4-8-22-18/h3-4,7-8,11-12H,1-2,5,9-10,13-14H2,(H,21,22)
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n/an/a>30n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM506363
PNG
(US11045455, Compound 5)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C18H17N7O2S/c1-2-28(26,27)24-11-18(12-24,4-5-19)25-10-14(9-23-25)16-13(7-20)8-22-17-15(16)3-6-21-17/h3,6,8-10H,2,4,11-12H2,1H3,(H,21,22)
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n/an/a 33.8n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM506381
PNG
(US11045455, Compound 30)
Show SMILES FC(F)(F)CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C18H17F3N6O2S/c19-18(20,21)4-8-30(28,29)26-11-17(12-26,3-5-22)27-10-13(9-25-27)14-1-6-23-16-15(14)2-7-24-16/h1-2,6-7,9-10H,3-4,8,11-12H2,(H,23,24)
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n/an/a 36.5n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM506374
PNG
(US11045455, Compound 8)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C17H18N6O2S/c1-2-26(24,25)22-11-17(12-22,5-6-18)23-10-13(9-21-23)14-3-7-19-16-15(14)4-8-20-16/h3-4,7-10H,2,5,11-12H2,1H3,(H,19,20)
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n/an/a 47.9n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2


(Homo sapiens (Human))
BDBM506381
PNG
(US11045455, Compound 30)
Show SMILES FC(F)(F)CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C18H17F3N6O2S/c19-18(20,21)4-8-30(28,29)26-11-17(12-26,3-5-22)27-10-13(9-25-27)14-1-6-23-16-15(14)2-7-24-16/h1-2,6-7,9-10H,3-4,8,11-12H2,(H,23,24)
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n/an/a 58.2n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
1. Test Materials JAK1, JAK2, JAK3 and TYK2 enzymes were purchased from Life Technologies; and substrate GFP-STAT1 was purchased from Life Tec...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 2D6


(Homo sapiens (Human))
BDBM506394
PNG
(US11045455, Compound 48)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(c(Cl)n1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C17H17ClN6O2S/c1-2-27(25,26)23-10-17(11-23,5-6-19)24-9-14(15(18)22-24)12-3-7-20-16-13(12)4-8-21-16/h3-4,7-9H,2,5,10-11H2,1H3,(H,20,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 3A4


(Homo sapiens (Human))
BDBM506395
PNG
(US11045455, Compound 49)
Show SMILES CC(C)S(=O)(=O)N1CC(CC#N)(C1)n1cc(c(C)n1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H21N7O2S/c1-12(2)28(26,27)24-9-18(10-24,5-6-19)25-8-15(13(3)23-25)16-14-4-7-20-17(14)22-11-21-16/h4,7-8,11-12H,5,9-10H2,1-3H3,(H,20,21,22)
PDB
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n/an/a>1.00E+4n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 2D6


(Homo sapiens (Human))
BDBM506393
PNG
(US11045455, Compound 39)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cc1C#N)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H17N7O2S/c1-2-28(26,27)24-10-18(11-24,4-5-19)25-9-13(7-14(25)8-20)16-15-3-6-21-17(15)23-12-22-16/h3,6-7,9,12H,2,4,10-11H2,1H3,(H,21,22,23)
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n/an/a>1.00E+4n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 1A


(Homo sapiens (Human))
BDBM506386
PNG
(US11045455, Compound 43)
Show SMILES CC(C)S(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C19H19N7O2S/c1-13(2)29(27,28)25-11-19(12-25,4-5-20)26-10-15(9-24-26)17-14(7-21)8-23-18-16(17)3-6-22-18/h3,6,8-10,13H,4,11-12H2,1-2H3,(H,22,23)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 3A4


(Homo sapiens (Human))
BDBM506394
PNG
(US11045455, Compound 48)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(c(Cl)n1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C17H17ClN6O2S/c1-2-27(25,26)23-10-17(11-23,5-6-19)24-9-14(15(18)22-24)12-3-7-20-16-13(12)4-8-21-16/h3-4,7-9H,2,5,10-11H2,1H3,(H,20,21)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 1A


(Homo sapiens (Human))
BDBM506379
PNG
(US11045455, Compound 25)
Show SMILES CC(C)CS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C19H22N6O2S/c1-14(2)11-28(26,27)24-12-19(13-24,5-6-20)25-10-15(9-23-25)16-3-7-21-18-17(16)4-8-22-18/h3-4,7-10,14H,5,11-13H2,1-2H3,(H,21,22)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 3A4


(Homo sapiens (Human))
BDBM506377
PNG
(US11045455, Compound 19)
Show SMILES CS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C16H16N6O2S/c1-25(23,24)21-10-16(11-21,4-5-17)22-9-12(8-20-22)13-2-6-18-15-14(13)3-7-19-15/h2-3,6-9H,4,10-11H2,1H3,(H,18,19)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 1A


(Homo sapiens (Human))
BDBM506363
PNG
(US11045455, Compound 5)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C18H17N7O2S/c1-2-28(26,27)24-11-18(12-24,4-5-19)25-10-14(9-23-25)16-13(7-20)8-22-17-15(16)3-6-21-17/h3,6,8-10H,2,4,11-12H2,1H3,(H,21,22)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 3A4


(Homo sapiens (Human))
BDBM506397
PNG
(US11045455, Compound 52 | US11045455, Compound 52-...)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(F)cnc2[nH]ccc12
Show InChI InChI=1S/C17H17FN6O2S/c1-2-27(25,26)23-10-17(11-23,4-5-19)24-9-12(7-22-24)15-13-3-6-20-16(13)21-8-14(15)18/h3,6-9H,2,4,10-11H2,1H3,(H,20,21)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 2D6


(Homo sapiens (Human))
BDBM506395
PNG
(US11045455, Compound 49)
Show SMILES CC(C)S(=O)(=O)N1CC(CC#N)(C1)n1cc(c(C)n1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H21N7O2S/c1-12(2)28(26,27)24-9-18(10-24,5-6-19)25-8-15(13(3)23-25)16-14-4-7-20-17(14)22-11-21-16/h4,7-8,11-12H,5,9-10H2,1-3H3,(H,20,21,22)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 3A4


(Homo sapiens (Human))
BDBM506393
PNG
(US11045455, Compound 39)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cc1C#N)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H17N7O2S/c1-2-28(26,27)24-10-18(11-24,4-5-19)25-9-13(7-14(25)8-20)16-15-3-6-21-17(15)23-12-22-16/h3,6-7,9,12H,2,4,10-11H2,1H3,(H,21,22,23)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 1A


(Homo sapiens (Human))
BDBM506393
PNG
(US11045455, Compound 39)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cc1C#N)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H17N7O2S/c1-2-28(26,27)24-10-18(11-24,4-5-19)25-9-13(7-14(25)8-20)16-15-3-6-21-17(15)23-12-22-16/h3,6-7,9,12H,2,4,10-11H2,1H3,(H,21,22,23)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 3A4


(Homo sapiens (Human))
BDBM506363
PNG
(US11045455, Compound 5)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C18H17N7O2S/c1-2-28(26,27)24-11-18(12-24,4-5-19)25-10-14(9-23-25)16-13(7-20)8-22-17-15(16)3-6-21-17/h3,6,8-10H,2,4,11-12H2,1H3,(H,21,22)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 3A4


(Homo sapiens (Human))
BDBM506379
PNG
(US11045455, Compound 25)
Show SMILES CC(C)CS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C19H22N6O2S/c1-14(2)11-28(26,27)24-12-19(13-24,5-6-20)25-10-15(9-23-25)16-3-7-21-18-17(16)4-8-22-18/h3-4,7-10,14H,5,11-13H2,1-2H3,(H,21,22)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 3A4


(Homo sapiens (Human))
BDBM506396
PNG
(US11045455, Compound 50 | US11045455, Compound 50-...)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(Cl)cnc2[nH]ccc12
Show InChI InChI=1S/C17H17ClN6O2S/c1-2-27(25,26)23-10-17(11-23,4-5-19)24-9-12(7-22-24)15-13-3-6-20-16(13)21-8-14(15)18/h3,6-9H,2,4,10-11H2,1H3,(H,20,21)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 2D6


(Homo sapiens (Human))
BDBM506396
PNG
(US11045455, Compound 50 | US11045455, Compound 50-...)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(Cl)cnc2[nH]ccc12
Show InChI InChI=1S/C17H17ClN6O2S/c1-2-27(25,26)23-10-17(11-23,4-5-19)24-9-12(7-22-24)15-13-3-6-20-16(13)21-8-14(15)18/h3,6-9H,2,4,10-11H2,1H3,(H,20,21)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 3A4


(Homo sapiens (Human))
BDBM506386
PNG
(US11045455, Compound 43)
Show SMILES CC(C)S(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C19H19N7O2S/c1-13(2)29(27,28)25-11-19(12-25,4-5-20)26-10-15(9-24-26)17-14(7-21)8-23-18-16(17)3-6-22-18/h3,6,8-10,13H,4,11-12H2,1-2H3,(H,22,23)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 2D6


(Homo sapiens (Human))
BDBM506386
PNG
(US11045455, Compound 43)
Show SMILES CC(C)S(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C19H19N7O2S/c1-13(2)29(27,28)25-11-19(12-25,4-5-20)26-10-15(9-24-26)17-14(7-21)8-23-18-16(17)3-6-22-18/h3,6,8-10,13H,4,11-12H2,1-2H3,(H,22,23)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 2D6


(Homo sapiens (Human))
BDBM506379
PNG
(US11045455, Compound 25)
Show SMILES CC(C)CS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C19H22N6O2S/c1-14(2)11-28(26,27)24-12-19(13-24,5-6-20)25-10-15(9-23-25)16-3-7-21-18-17(16)4-8-22-18/h3-4,7-10,14H,5,11-13H2,1-2H3,(H,21,22)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 1A


(Homo sapiens (Human))
BDBM506377
PNG
(US11045455, Compound 19)
Show SMILES CS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C16H16N6O2S/c1-25(23,24)21-10-16(11-21,4-5-17)22-9-12(8-20-22)13-2-6-18-15-14(13)3-7-19-15/h2-3,6-9H,4,10-11H2,1H3,(H,18,19)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 1A


(Homo sapiens (Human))
BDBM506397
PNG
(US11045455, Compound 52 | US11045455, Compound 52-...)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(F)cnc2[nH]ccc12
Show InChI InChI=1S/C17H17FN6O2S/c1-2-27(25,26)23-10-17(11-23,4-5-19)24-9-12(7-22-24)15-13-3-6-20-16(13)21-8-14(15)18/h3,6-9H,2,4,10-11H2,1H3,(H,20,21)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 1A


(Homo sapiens (Human))
BDBM506396
PNG
(US11045455, Compound 50 | US11045455, Compound 50-...)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(Cl)cnc2[nH]ccc12
Show InChI InChI=1S/C17H17ClN6O2S/c1-2-27(25,26)23-10-17(11-23,4-5-19)24-9-12(7-22-24)15-13-3-6-20-16(13)21-8-14(15)18/h3,6-9H,2,4,10-11H2,1H3,(H,20,21)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 1A


(Homo sapiens (Human))
BDBM506394
PNG
(US11045455, Compound 48)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(c(Cl)n1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C17H17ClN6O2S/c1-2-27(25,26)23-10-17(11-23,5-6-19)24-9-14(15(18)22-24)12-3-7-20-16-13(12)4-8-21-16/h3-4,7-9H,2,5,10-11H2,1H3,(H,20,21)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 2D6


(Homo sapiens (Human))
BDBM506377
PNG
(US11045455, Compound 19)
Show SMILES CS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C16H16N6O2S/c1-25(23,24)21-10-16(11-21,4-5-17)22-9-12(8-20-22)13-2-6-18-15-14(13)3-7-19-15/h2-3,6-9H,4,10-11H2,1H3,(H,18,19)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 2D6


(Homo sapiens (Human))
BDBM506363
PNG
(US11045455, Compound 5)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C18H17N7O2S/c1-2-28(26,27)24-11-18(12-24,4-5-19)25-10-14(9-23-25)16-13(7-20)8-22-17-15(16)3-6-21-17/h3,6,8-10H,2,4,11-12H2,1H3,(H,21,22)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 1A


(Homo sapiens (Human))
BDBM506395
PNG
(US11045455, Compound 49)
Show SMILES CC(C)S(=O)(=O)N1CC(CC#N)(C1)n1cc(c(C)n1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H21N7O2S/c1-12(2)28(26,27)24-9-18(10-24,5-6-19)25-8-15(13(3)23-25)16-14-4-7-20-17(14)22-11-21-16/h4,7-8,11-12H,5,9-10H2,1-3H3,(H,20,21,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 2D6


(Homo sapiens (Human))
BDBM506397
PNG
(US11045455, Compound 52 | US11045455, Compound 52-...)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(F)cnc2[nH]ccc12
Show InChI InChI=1S/C17H17FN6O2S/c1-2-27(25,26)23-10-17(11-23,4-5-19)24-9-12(7-22-24)15-13-3-6-20-16(13)21-8-14(15)18/h3,6-9H,2,4,10-11H2,1H3,(H,20,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
According to the experimental data in Table 2-2, in this test, the 50% inhibitory concentrations (IC50) of the test compounds on CYP1A2, CYP3A4 and C...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 2/HERG


(Homo sapiens (Human))
BDBM506358
PNG
(US11045455, Compound 2)
Show SMILES CS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C17H15N7O2S/c1-27(25,26)23-10-17(11-23,3-4-18)24-9-13(8-22-24)15-12(6-19)7-21-16-14(15)2-5-20-16/h2,5,7-9H,3,10-11H2,1H3,(H,20,21)
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n/an/a>3.00E+4n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The effect of test compounds on hERG potassium channel were determined using Predictor hERG Fluorescence Polarization Assay at concentrations of 3, 1...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 2/HERG


(Homo sapiens (Human))
BDBM506378
PNG
(US11045455, Compound 23)
Show SMILES CCCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C18H20N6O2S/c1-2-9-27(25,26)23-12-18(13-23,5-6-19)24-11-14(10-22-24)15-3-7-20-17-16(15)4-8-21-17/h3-4,7-8,10-11H,2,5,9,12-13H2,1H3,(H,20,21)
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n/an/a>3.00E+4n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The effect of test compounds on hERG potassium channel were determined using Predictor hERG Fluorescence Polarization Assay at concentrations of 3, 1...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 2/HERG


(Homo sapiens (Human))
BDBM506382
PNG
(US11045455, Compound 31)
Show SMILES CC1(CC1)S(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C19H20N6O2S/c1-18(4-5-18)28(26,27)24-12-19(13-24,6-7-20)25-11-14(10-23-25)15-2-8-21-17-16(15)3-9-22-17/h2-3,8-11H,4-6,12-13H2,1H3,(H,21,22)
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n/an/a>3.00E+4n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The effect of test compounds on hERG potassium channel were determined using Predictor hERG Fluorescence Polarization Assay at concentrations of 3, 1...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 2/HERG


(Homo sapiens (Human))
BDBM506375
PNG
(US11045455, Compound 14)
Show SMILES CN(C)S(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C17H19N7O2S/c1-22(2)27(25,26)23-11-17(12-23,5-6-18)24-10-13(9-21-24)14-3-7-19-16-15(14)4-8-20-16/h3-4,7-10H,5,11-12H2,1-2H3,(H,19,20)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The effect of test compounds on hERG potassium channel were determined using Predictor hERG Fluorescence Polarization Assay at concentrations of 3, 1...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 2/HERG


(Homo sapiens (Human))
BDBM506397
PNG
(US11045455, Compound 52 | US11045455, Compound 52-...)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(F)cnc2[nH]ccc12
Show InChI InChI=1S/C17H17FN6O2S/c1-2-27(25,26)23-10-17(11-23,4-5-19)24-9-12(7-22-24)15-13-3-6-20-16(13)21-8-14(15)18/h3,6-9H,2,4,10-11H2,1H3,(H,20,21)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The effect of test compounds on hERG potassium channel were determined using Predictor hERG Fluorescence Polarization Assay at concentrations of 3, 1...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 2/HERG


(Homo sapiens (Human))
BDBM506388
PNG
(US11045455, Compound 45 | US11045455, Compound 45-...)
Show SMILES CCS(=O)(=O)N1CC(C1)(C(C)C#N)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The effect of test compounds on hERG potassium channel were determined using Predictor hERG Fluorescence Polarization Assay at concentrations of 3, 1...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 2/HERG


(Homo sapiens (Human))
BDBM506386
PNG
(US11045455, Compound 43)
Show SMILES CC(C)S(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C19H19N7O2S/c1-13(2)29(27,28)25-11-19(12-25,4-5-20)26-10-15(9-24-26)17-14(7-21)8-23-18-16(17)3-6-22-18/h3,6,8-10,13H,4,11-12H2,1-2H3,(H,22,23)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The effect of test compounds on hERG potassium channel were determined using Predictor hERG Fluorescence Polarization Assay at concentrations of 3, 1...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 2/HERG


(Homo sapiens (Human))
BDBM506385
PNG
(US11045455, Compound 12-2)
Show SMILES CCS(=O)(=O)N1CC(C1)(C(C)C#N)n1cc(cn1)-c1ncnc2[nH]ccc12
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The effect of test compounds on hERG potassium channel were determined using Predictor hERG Fluorescence Polarization Assay at concentrations of 3, 1...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 2/HERG


(Homo sapiens (Human))
BDBM506396
PNG
(US11045455, Compound 50 | US11045455, Compound 50-...)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(Cl)cnc2[nH]ccc12
Show InChI InChI=1S/C17H17ClN6O2S/c1-2-27(25,26)23-10-17(11-23,4-5-19)24-9-12(7-22-24)15-13-3-6-20-16(13)21-8-14(15)18/h3,6-9H,2,4,10-11H2,1H3,(H,20,21)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The effect of test compounds on hERG potassium channel were determined using Predictor hERG Fluorescence Polarization Assay at concentrations of 3, 1...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 2/HERG


(Homo sapiens (Human))
BDBM506388
PNG
(US11045455, Compound 45 | US11045455, Compound 45-...)
Show SMILES CCS(=O)(=O)N1CC(C1)(C(C)C#N)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The effect of test compounds on hERG potassium channel were determined using Predictor hERG Fluorescence Polarization Assay at concentrations of 3, 1...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 2/HERG


(Homo sapiens (Human))
BDBM506381
PNG
(US11045455, Compound 30)
Show SMILES FC(F)(F)CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C18H17F3N6O2S/c19-18(20,21)4-8-30(28,29)26-11-17(12-26,3-5-22)27-10-13(9-25-27)14-1-6-23-16-15(14)2-7-24-16/h1-2,6-7,9-10H,3-4,8,11-12H2,(H,23,24)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The effect of test compounds on hERG potassium channel were determined using Predictor hERG Fluorescence Polarization Assay at concentrations of 3, 1...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 2/HERG


(Homo sapiens (Human))
BDBM506377
PNG
(US11045455, Compound 19)
Show SMILES CS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C16H16N6O2S/c1-25(23,24)21-10-16(11-21,4-5-17)22-9-12(8-20-22)13-2-6-18-15-14(13)3-7-19-15/h2-3,6-9H,4,10-11H2,1H3,(H,18,19)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The effect of test compounds on hERG potassium channel were determined using Predictor hERG Fluorescence Polarization Assay at concentrations of 3, 1...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 2/HERG


(Homo sapiens (Human))
BDBM506397
PNG
(US11045455, Compound 52 | US11045455, Compound 52-...)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(F)cnc2[nH]ccc12
Show InChI InChI=1S/C17H17FN6O2S/c1-2-27(25,26)23-10-17(11-23,4-5-19)24-9-12(7-22-24)15-13-3-6-20-16(13)21-8-14(15)18/h3,6-9H,2,4,10-11H2,1H3,(H,20,21)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The effect of test compounds on hERG potassium channel were determined using Predictor hERG Fluorescence Polarization Assay at concentrations of 3, 1...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 2/HERG


(Homo sapiens (Human))
BDBM506380
PNG
(US11045455, Compound 26)
Show SMILES O=S(=O)(C1CC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C18H18N6O2S/c19-6-5-18(11-23(12-18)27(25,26)14-1-2-14)24-10-13(9-22-24)15-3-7-20-17-16(15)4-8-21-17/h3-4,7-10,14H,1-2,5,11-12H2,(H,20,21)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The effect of test compounds on hERG potassium channel were determined using Predictor hERG Fluorescence Polarization Assay at concentrations of 3, 1...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 2/HERG


(Homo sapiens (Human))
BDBM506379
PNG
(US11045455, Compound 25)
Show SMILES CC(C)CS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C19H22N6O2S/c1-14(2)11-28(26,27)24-12-19(13-24,5-6-20)25-10-15(9-23-25)16-3-7-21-18-17(16)4-8-22-18/h3-4,7-10,14H,5,11-13H2,1-2H3,(H,21,22)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The effect of test compounds on hERG potassium channel were determined using Predictor hERG Fluorescence Polarization Assay at concentrations of 3, 1...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 2/HERG


(Homo sapiens (Human))
BDBM506363
PNG
(US11045455, Compound 5)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C18H17N7O2S/c1-2-28(26,27)24-11-18(12-24,4-5-19)25-10-14(9-23-25)16-13(7-20)8-22-17-15(16)3-6-21-17/h3,6,8-10H,2,4,11-12H2,1H3,(H,21,22)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The effect of test compounds on hERG potassium channel were determined using Predictor hERG Fluorescence Polarization Assay at concentrations of 3, 1...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 2/HERG


(Homo sapiens (Human))
BDBM506396
PNG
(US11045455, Compound 50 | US11045455, Compound 50-...)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(Cl)cnc2[nH]ccc12
Show InChI InChI=1S/C17H17ClN6O2S/c1-2-27(25,26)23-10-17(11-23,4-5-19)24-9-12(7-22-24)15-13-3-6-20-16(13)21-8-14(15)18/h3,6-9H,2,4,10-11H2,1H3,(H,20,21)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The effect of test compounds on hERG potassium channel were determined using Predictor hERG Fluorescence Polarization Assay at concentrations of 3, 1...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 2/HERG


(Homo sapiens (Human))
BDBM506395
PNG
(US11045455, Compound 49)
Show SMILES CC(C)S(=O)(=O)N1CC(CC#N)(C1)n1cc(c(C)n1)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H21N7O2S/c1-12(2)28(26,27)24-9-18(10-24,5-6-19)25-8-15(13(3)23-25)16-14-4-7-20-17(14)22-11-21-16/h4,7-8,11-12H,5,9-10H2,1-3H3,(H,20,21,22)
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SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The effect of test compounds on hERG potassium channel were determined using Predictor hERG Fluorescence Polarization Assay at concentrations of 3, 1...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 2/HERG


(Homo sapiens (Human))
BDBM506394
PNG
(US11045455, Compound 48)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(c(Cl)n1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C17H17ClN6O2S/c1-2-27(25,26)23-10-17(11-23,5-6-19)24-9-14(15(18)22-24)12-3-7-20-16-13(12)4-8-21-16/h3-4,7-9H,2,5,10-11H2,1H3,(H,20,21)
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n/an/a>3.00E+4n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The effect of test compounds on hERG potassium channel were determined using Predictor hERG Fluorescence Polarization Assay at concentrations of 3, 1...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 2/HERG


(Homo sapiens (Human))
BDBM506390
PNG
(US11045455, Compound 35)
Show SMILES O=S(=O)(N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12)N1CCCC1
Show InChI InChI=1S/C19H21N7O2S/c20-6-5-19(13-25(14-19)29(27,28)24-9-1-2-10-24)26-12-15(11-23-26)16-3-7-21-18-17(16)4-8-22-18/h3-4,7-8,11-12H,1-2,5,9-10,13-14H2,(H,21,22)
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n/an/a>3.00E+4n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The effect of test compounds on hERG potassium channel were determined using Predictor hERG Fluorescence Polarization Assay at concentrations of 3, 1...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 2/HERG


(Homo sapiens (Human))
BDBM506389
PNG
(US11045455, Compound 13)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(c(C)n1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C18H20N6O2S/c1-3-27(25,26)23-11-18(12-23,6-7-19)24-10-16(13(2)22-24)14-4-8-20-17-15(14)5-9-21-17/h4-5,8-10H,3,6,11-12H2,1-2H3,(H,20,21)
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n/an/a>3.00E+4n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The effect of test compounds on hERG potassium channel were determined using Predictor hERG Fluorescence Polarization Assay at concentrations of 3, 1...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 2/HERG


(Homo sapiens (Human))
BDBM506376
PNG
(US11045455, Compound 17)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1ccc(c1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C19H18N6O2S/c1-2-28(26,27)25-12-19(13-25,5-6-20)24-8-4-14(11-24)17-15(9-21)10-23-18-16(17)3-7-22-18/h3-4,7-8,10-11H,2,5,12-13H2,1H3,(H,22,23)
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n/an/a>3.00E+4n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The effect of test compounds on hERG potassium channel were determined using Predictor hERG Fluorescence Polarization Assay at concentrations of 3, 1...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 2/HERG


(Homo sapiens (Human))
BDBM506374
PNG
(US11045455, Compound 8)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C17H18N6O2S/c1-2-26(24,25)22-11-17(12-22,5-6-18)23-10-13(9-21-23)14-3-7-19-16-15(14)4-8-20-16/h3-4,7-10H,2,5,11-12H2,1H3,(H,19,20)
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n/an/a>3.00E+4n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The effect of test compounds on hERG potassium channel were determined using Predictor hERG Fluorescence Polarization Assay at concentrations of 3, 1...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 2/HERG


(Homo sapiens (Human))
BDBM506393
PNG
(US11045455, Compound 39)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cc1C#N)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H17N7O2S/c1-2-28(26,27)24-10-18(11-24,4-5-19)25-9-13(7-14(25)8-20)16-15-3-6-21-17(15)23-12-22-16/h3,6-7,9,12H,2,4,10-11H2,1H3,(H,21,22,23)
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n/an/a>3.00E+4n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The effect of test compounds on hERG potassium channel were determined using Predictor hERG Fluorescence Polarization Assay at concentrations of 3, 1...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor 2/HERG


(Homo sapiens (Human))
BDBM506348
PNG
(US11045455, Compound 1)
Show SMILES CC1(CC1)S(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1c(cnc2[nH]ccc12)C#N
Show InChI InChI=1S/C20H19N7O2S/c1-19(3-4-19)30(28,29)26-12-20(13-26,5-6-21)27-11-15(10-25-27)17-14(8-22)9-24-18-16(17)2-7-23-18/h2,7,9-11H,3-5,12-13H2,1H3,(H,23,24)
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n/an/a>3.00E+4n/an/an/an/an/an/a



SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.

US Patent


Assay Description
The effect of test compounds on hERG potassium channel were determined using Predictor hERG Fluorescence Polarization Assay at concentrations of 3, 1...


US Patent US11045455 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%