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Patent code US11045457

Compile Data Set for Download or QSAR

Found 445 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506557
PNG
(US11045457, Example 157)
Show SMILES Cc1ccccc1[C@@H]1CNCC[C@H]1NC(=O)C(C)(C)COc1ncccc1C(F)(F)F
Show InChI InChI=1S/C23H28F3N3O2/c1-15-7-4-5-8-16(15)17-13-27-12-10-19(17)29-21(30)22(2,3)14-31-20-18(23(24,25)26)9-6-11-28-20/h4-9,11,17,19,27H,10,12-14H2,1-3H3,(H,29,30)/t17-,19+/m0/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506586
PNG
(US11045457, Example 187)
Show SMILES CC(C)(COc1ccccc1Cl)C(=O)N[C@H]1CCNC[C@@H]1F
Show InChI InChI=1S/C16H22ClFN2O2/c1-16(2,10-22-14-6-4-3-5-11(14)17)15(21)20-13-7-8-19-9-12(13)18/h3-6,12-13,19H,7-10H2,1-2H3,(H,20,21)/t12-,13-/m0/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506515
PNG
(US11045457, Example 115)
Show SMILES CC[C@H]1CN(C)CC[C@@H]1NC(=O)C(C)(C)COc1ncccc1OC(F)(F)F
Show InChI InChI=1S/C19H28F3N3O3/c1-5-13-11-25(4)10-8-14(13)24-17(26)18(2,3)12-27-16-15(7-6-9-23-16)28-19(20,21)22/h6-7,9,13-14H,5,8,10-12H2,1-4H3,(H,24,26)/t13-,14-/m0/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506558
PNG
(US11045457, Example 158)
Show SMILES CC(C)(COc1ncccc1C(F)(F)F)C(=O)N[C@H]1CCNC[C@@H]1F
Show InChI InChI=1S/C16H21F4N3O2/c1-15(2,14(24)23-12-5-7-21-8-11(12)17)9-25-13-10(16(18,19)20)4-3-6-22-13/h3-4,6,11-12,21H,5,7-9H2,1-2H3,(H,23,24)/t11-,12-/m0/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506544
PNG
(US11045457, Example 144)
Show SMILES CC[C@@H]1CN(C)CC[C@H]1NC(=O)C(C)(C)COc1ncccc1C(F)(F)F
Show InChI InChI=1S/C19H28F3N3O2/c1-5-13-11-25(4)10-8-15(13)24-17(26)18(2,3)12-27-16-14(19(20,21)22)7-6-9-23-16/h6-7,9,13,15H,5,8,10-12H2,1-4H3,(H,24,26)/t13-,15-/m1/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506504
PNG
(US11045457, Example 104)
Show SMILES CCc1ccccc1OCC(C)(C)C(=O)NC1CCN(CC(=O)c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C26H33ClN2O3/c1-4-19-7-5-6-8-24(19)32-18-26(2,3)25(31)28-22-13-15-29(16-14-22)17-23(30)20-9-11-21(27)12-10-20/h5-12,22H,4,13-18H2,1-3H3,(H,28,31)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506502
PNG
(US11045457, Example 102)
Show SMILES CN1CCC(CC1)NC(=O)C(C)(C)COc1ccccc1OC(F)(F)F
Show InChI InChI=1S/C18H25F3N2O3/c1-17(2,16(24)22-13-8-10-23(3)11-9-13)12-25-14-6-4-5-7-15(14)26-18(19,20)21/h4-7,13H,8-12H2,1-3H3,(H,22,24)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506510
PNG
(US11045457, Example 110 | US11045457, Example 145)
Show SMILES CC[C@H]1CN(C)CC[C@@H]1NC(=O)C(C)(C)COc1ncccc1C(F)(F)F
Show InChI InChI=1S/C19H28F3N3O2/c1-5-13-11-25(4)10-8-15(13)24-17(26)18(2,3)12-27-16-14(19(20,21)22)7-6-9-23-16/h6-7,9,13,15H,5,8,10-12H2,1-4H3,(H,24,26)/t13-,15-/m0/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506430
PNG
(US11045457, Example 30)
Show SMILES CN1C[C@@H](NC(=O)C(C)(C)COc2ncccc2OC(F)(F)F)[C@@H](C1)c1cnn(C)c1C
Show InChI InChI=1S/C21H28F3N5O3/c1-13-14(9-26-29(13)5)15-10-28(4)11-16(15)27-19(30)20(2,3)12-31-18-17(7-6-8-25-18)32-21(22,23)24/h6-9,15-16H,10-12H2,1-5H3,(H,27,30)/t15-,16+/m0/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506507
PNG
(US11045457, Example 107)
Show SMILES C[C@H]1CN(C)CC[C@@H]1NC(=O)C(C)(C)COc1ncccc1OC(F)(F)F
Show InChI InChI=1S/C18H26F3N3O3/c1-12-10-24(4)9-7-13(12)23-16(25)17(2,3)11-26-15-14(6-5-8-22-15)27-18(19,20)21/h5-6,8,12-13H,7,9-11H2,1-4H3,(H,23,25)/t12-,13-/m0/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506615
PNG
(US11045457, Example 216)
Show SMILES C[C@H]1CNCC[C@@H]1NC(=O)C(F)(F)COc1ccccc1Cl
Show InChI InChI=1S/C15H19ClF2N2O2/c1-10-8-19-7-6-12(10)20-14(21)15(17,18)9-22-13-5-3-2-4-11(13)16/h2-5,10,12,19H,6-9H2,1H3,(H,20,21)/t10-,12-/m0/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506428
PNG
(US11045457, Example 28)
Show SMILES CN1C[C@@H](NC(=O)C(C)(C)COc2ncccc2C(F)(F)F)[C@@H](C1)c1cnn(C)c1C
Show InChI InChI=1S/C21H28F3N5O2/c1-13-14(9-26-29(13)5)15-10-28(4)11-17(15)27-19(30)20(2,3)12-31-18-16(21(22,23)24)7-6-8-25-18/h6-9,15,17H,10-12H2,1-5H3,(H,27,30)/t15-,17+/m0/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506593
PNG
(US11045457, Example 194)
Show SMILES C[C@@H]1C[C@@H](CCN1C)NC(=O)C(F)(F)COc1ncccc1C1CC1
Show InChI InChI=1S/C18H25F2N3O2/c1-12-10-14(7-9-23(12)2)22-17(24)18(19,20)11-25-16-15(13-5-6-13)4-3-8-21-16/h3-4,8,12-14H,5-7,9-11H2,1-2H3,(H,22,24)/t12-,14-/m1/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506561
PNG
(US11045457, Example 161)
Show SMILES CN1CC[C@@H](NC(=O)C(C)(C)COc2ncccc2C(F)(F)F)[C@@H](C1)c1ccccc1C
Show InChI InChI=1S/C24H30F3N3O2/c1-16-8-5-6-9-17(16)18-14-30(4)13-11-20(18)29-22(31)23(2,3)15-32-21-19(24(25,26)27)10-7-12-28-21/h5-10,12,18,20H,11,13-15H2,1-4H3,(H,29,31)/t18-,20+/m0/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506608
PNG
(US11045457, Example 209)
Show SMILES C[C@H]1CNCC[C@@H]1NC(=O)C(F)(F)COc1ncccc1C1CC1
Show InChI InChI=1S/C17H23F2N3O2/c1-11-9-20-8-6-14(11)22-16(23)17(18,19)10-24-15-13(12-4-5-12)3-2-7-21-15/h2-3,7,11-12,14,20H,4-6,8-10H2,1H3,(H,22,23)/t11-,14-/m0/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506612
PNG
(US11045457, Example 213)
Show SMILES CC(C)(COc1ccccc1Cl)C(=O)NC1CCNCC1
Show InChI InChI=1S/C16H23ClN2O2/c1-16(2,11-21-14-6-4-3-5-13(14)17)15(20)19-12-7-9-18-10-8-12/h3-6,12,18H,7-11H2,1-2H3,(H,19,20)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506589
PNG
(US11045457, Example 190)
Show SMILES C[C@H]1CNCC[C@@H]1NC(=O)C(C)(C)COc1ccccc1Cl
Show InChI InChI=1S/C17H25ClN2O2/c1-12-10-19-9-8-14(12)20-16(21)17(2,3)11-22-15-7-5-4-6-13(15)18/h4-7,12,14,19H,8-11H2,1-3H3,(H,20,21)/t12-,14-/m0/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506427
PNG
(US11045457, Example 27)
Show SMILES CN1C[C@@H](NC(=O)C(C)(C)COc2ncccc2C2CC2)[C@@H](C1)c1cnn(C)c1C
Show InChI InChI=1S/C23H33N5O2/c1-15-18(11-25-28(15)5)19-12-27(4)13-20(19)26-22(29)23(2,3)14-30-21-17(16-8-9-16)7-6-10-24-21/h6-7,10-11,16,19-20H,8-9,12-14H2,1-5H3,(H,26,29)/t19-,20+/m0/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506470
PNG
(US11045457, Example 70)
Show SMILES CN1CCC(CC1)NC(=O)C(C)(C)COc1ccccc1C1CC1
Show InChI InChI=1S/C20H30N2O2/c1-20(2,19(23)21-16-10-12-22(3)13-11-16)14-24-18-7-5-4-6-17(18)15-8-9-15/h4-7,15-16H,8-14H2,1-3H3,(H,21,23)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506587
PNG
(US11045457, Example 188)
Show SMILES CN1CC[C@H](NC(=O)C(C)(C)COc2ccccc2Cl)[C@@H](F)C1
Show InChI InChI=1S/C17H24ClFN2O2/c1-17(2,11-23-15-7-5-4-6-12(15)18)16(22)20-14-8-9-21(3)10-13(14)19/h4-7,13-14H,8-11H2,1-3H3,(H,20,22)/t13-,14-/m0/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506609
PNG
(US11045457, Example 210)
Show SMILES C[C@H]1CNCC[C@@H]1NC(=O)C(F)(F)COc1ncccc1OC(F)(F)F
Show InChI InChI=1S/C15H18F5N3O3/c1-9-7-21-6-4-10(9)23-13(24)14(16,17)8-25-12-11(3-2-5-22-12)26-15(18,19)20/h2-3,5,9-10,21H,4,6-8H2,1H3,(H,23,24)/t9-,10-/m0/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506606
PNG
(US11045457, Example 207)
Show SMILES F[C@H]1CNCC[C@@H]1NC(=O)C(F)(F)COc1ncccc1OC(F)(F)F
Show InChI InChI=1S/C14H15F6N3O3/c15-8-6-21-5-3-9(8)23-12(24)13(16,17)7-25-11-10(2-1-4-22-11)26-14(18,19)20/h1-2,4,8-9,21H,3,5-7H2,(H,23,24)/t8-,9-/m0/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506547
PNG
(US11045457, Example 147)
Show SMILES C[C@@H]1C[C@@H](CCN1C)NC(=O)C(C)(C)COc1ncccc1C1CC1
Show InChI InChI=1S/C20H31N3O2/c1-14-12-16(9-11-23(14)4)22-19(24)20(2,3)13-25-18-17(15-7-8-15)6-5-10-21-18/h5-6,10,14-16H,7-9,11-13H2,1-4H3,(H,22,24)/t14-,16-/m1/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506413
PNG
(BDBM506508 | US11045457, Example 13)
Show SMILES C[C@@H]1CN(C)CC[C@H]1NC(=O)C(C)(C)COc1ncccc1OC(F)(F)F
Show InChI InChI=1S/C18H26F3N3O3/c1-12-10-24(4)9-7-13(12)23-16(25)17(2,3)11-26-15-14(6-5-8-22-15)27-18(19,20)21/h5-6,8,12-13H,7,9-11H2,1-4H3,(H,23,25)/t12-,13-/m1/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506595
PNG
(US11045457, Example 196)
Show SMILES C[C@H]1CNCC[C@@H]1NC(=O)C(C)(C)COc1ccccc1F
Show InChI InChI=1S/C17H25FN2O2/c1-12-10-19-9-8-14(12)20-16(21)17(2,3)11-22-15-7-5-4-6-13(15)18/h4-7,12,14,19H,8-11H2,1-3H3,(H,20,21)/t12-,14-/m0/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506467
PNG
(US11045457, Example 67)
Show SMILES CN1CCC(CC1)NC(=O)C(C)(C)COc1ccccc1Br
Show InChI InChI=1S/C17H25BrN2O2/c1-17(2,12-22-15-7-5-4-6-14(15)18)16(21)19-13-8-10-20(3)11-9-13/h4-7,13H,8-12H2,1-3H3,(H,19,21)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506585
PNG
(US11045457, Example 186)
Show SMILES C[C@@H]1CN(C)CC[C@H]1NC(=O)C(C)(C)COc1ccccc1Cl
Show InChI InChI=1S/C18H27ClN2O2/c1-13-11-21(4)10-9-15(13)20-17(22)18(2,3)12-23-16-8-6-5-7-14(16)19/h5-8,13,15H,9-12H2,1-4H3,(H,20,22)/t13-,15-/m1/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506579
PNG
(US11045457, Example 179)
Show SMILES C[C@@H]1C[C@@H](CCN1C)NC(=O)C(C)(C)COc1ncccc1OC(F)(F)F
Show InChI InChI=1S/C18H26F3N3O3/c1-12-10-13(7-9-24(12)4)23-16(25)17(2,3)11-26-15-14(6-5-8-22-15)27-18(19,20)21/h5-6,8,12-13H,7,9-11H2,1-4H3,(H,23,25)/t12-,13-/m1/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506524
PNG
(US11045457, Example 124)
Show SMILES CN1CC[C@H](NC(=O)C(C)(C)COc2ncccc2OC(F)(F)F)[C@@H](F)C1
Show InChI InChI=1S/C17H23F4N3O3/c1-16(2,15(25)23-12-6-8-24(3)9-11(12)18)10-26-14-13(5-4-7-22-14)27-17(19,20)21/h4-5,7,11-12H,6,8-10H2,1-3H3,(H,23,25)/t11-,12-/m0/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506429
PNG
(US11045457, Example 29)
Show SMILES CN1C[C@@H](NC(=O)C(C)(C)COc2ncccc2OC(F)(F)F)[C@@H](C1)c1cn(C)nc1C
Show InChI InChI=1S/C21H28F3N5O3/c1-13-14(10-29(5)27-13)15-9-28(4)11-16(15)26-19(30)20(2,3)12-31-18-17(7-6-8-25-18)32-21(22,23)24/h6-8,10,15-16H,9,11-12H2,1-5H3,(H,26,30)/t15-,16+/m0/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506566
PNG
(US11045457, Example 166)
Show SMILES CN1CC[C@H](NC(=O)C(C)(C)COc2ncccc2OC(F)(F)F)[C@@H](C1)c1ccccc1
Show InChI InChI=1S/C23H28F3N3O3/c1-22(2,15-31-20-19(10-7-12-27-20)32-23(24,25)26)21(30)28-18-11-13-29(3)14-17(18)16-8-5-4-6-9-16/h4-10,12,17-18H,11,13-15H2,1-3H3,(H,28,30)/t17-,18-/m0/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506548
PNG
(US11045457, Example 148)
Show SMILES CN1C[C@H](NC(=O)C(C)(C)COc2ncccc2C(F)(F)F)C2(CC2)C1
Show InChI InChI=1S/C18H24F3N3O2/c1-16(2,11-26-14-12(18(19,20)21)5-4-8-22-14)15(25)23-13-9-24(3)10-17(13)6-7-17/h4-5,8,13H,6-7,9-11H2,1-3H3,(H,23,25)/t13-/m0/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506611
PNG
(US11045457, Example 212)
Show SMILES C[C@@H]1C[C@@H](CCN1)NC(=O)C(F)(F)COc1ncccc1OC(F)(F)F
Show InChI InChI=1S/C15H18F5N3O3/c1-9-7-10(4-6-21-9)23-13(24)14(16,17)8-25-12-11(3-2-5-22-12)26-15(18,19)20/h2-3,5,9-10,21H,4,6-8H2,1H3,(H,23,24)/t9-,10-/m1/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506525
PNG
(US11045457, Example 125)
Show SMILES CN1CC[C@H](NC(=O)C(C)(C)COc2ncccc2C(F)(F)F)[C@H](C1)c1cnn(c1)C(F)F
Show InChI InChI=1S/C21H26F5N5O2/c1-20(2,12-33-17-15(21(24,25)26)5-4-7-27-17)18(32)29-16-6-8-30(3)11-14(16)13-9-28-31(10-13)19(22)23/h4-5,7,9-10,14,16,19H,6,8,11-12H2,1-3H3,(H,29,32)/t14-,16+/m1/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506519
PNG
(US11045457, Example 119)
Show SMILES CN1CCC(NC(=O)C(C)(C)COc2ncccc2OC(F)(F)F)C2(CC2)C1
Show InChI InChI=1S/C19H26F3N3O3/c1-17(2,12-27-15-13(5-4-9-23-15)28-19(20,21)22)16(26)24-14-6-10-25(3)11-18(14)7-8-18/h4-5,9,14H,6-8,10-12H2,1-3H3,(H,24,26)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506471
PNG
(US11045457, Example 71)
Show SMILES CN1CC[C@H](C1)NC(=O)C(C)(C)COc1ccccc1C1CC1
Show InChI InChI=1S/C19H28N2O2/c1-19(2,18(22)20-15-10-11-21(3)12-15)13-23-17-7-5-4-6-16(17)14-8-9-14/h4-7,14-15H,8-13H2,1-3H3,(H,20,22)/t15-/m1/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506426
PNG
(US11045457, Example 26)
Show SMILES CN1C[C@@H](NC(=O)C(C)(C)COc2ncccc2C)[C@@H](C1)c1cnn(C)c1C
Show InChI InChI=1S/C21H31N5O2/c1-14-8-7-9-22-19(14)28-13-21(3,4)20(27)24-18-12-25(5)11-17(18)16-10-23-26(6)15(16)2/h7-10,17-18H,11-13H2,1-6H3,(H,24,27)/t17-,18+/m0/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506550
PNG
(US11045457, Example 150)
Show SMILES CN1C[C@H](NC(=O)C(C)(C)COc2ncccc2OC(F)(F)F)C2(CC2)C1
Show InChI InChI=1S/C18H24F3N3O3/c1-16(2,15(25)23-13-9-24(3)10-17(13)6-7-17)11-26-14-12(5-4-8-22-14)27-18(19,20)21/h4-5,8,13H,6-7,9-11H2,1-3H3,(H,23,25)/t13-/m0/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506505
PNG
(US11045457, Example 105)
Show SMILES C[C@H]1CN(C)CC[C@@H]1NC(=O)C(C)(C)COc1ncccc1C(F)(F)F
Show InChI InChI=1S/C18H26F3N3O2/c1-12-10-24(4)9-7-14(12)23-16(25)17(2,3)11-26-15-13(18(19,20)21)6-5-8-22-15/h5-6,8,12,14H,7,9-11H2,1-4H3,(H,23,25)/t12-,14-/m0/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506538
PNG
(US11045457, Example 138)
Show SMILES CN1CC(NC(=O)C(C)(C)COc2ncccc2C(F)(F)F)C2(CC2)C1
Show InChI InChI=1S/C18H24F3N3O2/c1-16(2,11-26-14-12(18(19,20)21)5-4-8-22-14)15(25)23-13-9-24(3)10-17(13)6-7-17/h4-5,8,13H,6-7,9-11H2,1-3H3,(H,23,25)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506528
PNG
(US11045457, Example 128)
Show SMILES CC[C@H]1CN(C)CC[C@@H]1NC(=O)C(C)(C)COc1ncc(C)cc1C
Show InChI InChI=1S/C20H33N3O2/c1-7-16-12-23(6)9-8-17(16)22-19(24)20(4,5)13-25-18-15(3)10-14(2)11-21-18/h10-11,16-17H,7-9,12-13H2,1-6H3,(H,22,24)/t16-,17-/m0/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506469
PNG
(US11045457, Example 69)
Show SMILES CN1CC[C@H](C1)NC(=O)C(C)(C)COc1ccccc1Br
Show InChI InChI=1S/C16H23BrN2O2/c1-16(2,11-21-14-7-5-4-6-13(14)17)15(20)18-12-8-9-19(3)10-12/h4-7,12H,8-11H2,1-3H3,(H,18,20)/t12-/m1/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506539
PNG
(US11045457, Example 139 | US11045457, Example 177)
Show SMILES C[C@@H]1C[C@H](CCN1C)NC(=O)C(C)(C)COc1ncccc1C(F)(F)F
Show InChI InChI=1S/C18H26F3N3O2/c1-12-10-13(7-9-24(12)4)23-16(25)17(2,3)11-26-15-14(18(19,20)21)6-5-8-22-15/h5-6,8,12-13H,7,9-11H2,1-4H3,(H,23,25)/t12-,13+/m1/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506610
PNG
(US11045457, Example 211)
Show SMILES C[C@@H]1C[C@@H](CCN1)NC(=O)C(F)(F)COc1ncccc1C1CC1
Show InChI InChI=1S/C17H23F2N3O2/c1-11-9-13(6-8-20-11)22-16(23)17(18,19)10-24-15-14(12-4-5-12)3-2-7-21-15/h2-3,7,11-13,20H,4-6,8-10H2,1H3,(H,22,23)/t11-,13-/m1/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506416
PNG
(US11045457, Example 16)
Show SMILES CC(C)[C@@H]1CN(C)C[C@H]1NC(=O)C(C)(C)COc1ncccc1OC(F)(F)F
Show InChI InChI=1S/C19H28F3N3O3/c1-12(2)13-9-25(5)10-14(13)24-17(26)18(3,4)11-27-16-15(7-6-8-23-16)28-19(20,21)22/h6-8,12-14H,9-11H2,1-5H3,(H,24,26)/t13-,14+/m0/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506420
PNG
(US11045457, Example 20)
Show SMILES C[C@@H]1CN(C)CC[C@H]1NC(=O)C(C)(C)COc1ncccc1C1CC1
Show InChI InChI=1S/C20H31N3O2/c1-14-12-23(4)11-9-17(14)22-19(24)20(2,3)13-25-18-16(15-7-8-15)6-5-10-21-18/h5-6,10,14-15,17H,7-9,11-13H2,1-4H3,(H,22,24)/t14-,17-/m1/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506555
PNG
(US11045457, Example 155)
Show SMILES CN([C@@H]1CCNC[C@H]1c1ccccc1C)C(=O)C(C)(C)COc1ncccc1C(F)(F)F
Show InChI InChI=1S/C24H30F3N3O2/c1-16-8-5-6-9-17(16)18-14-28-13-11-20(18)30(4)22(31)23(2,3)15-32-21-19(24(25,26)27)10-7-12-29-21/h5-10,12,18,20,28H,11,13-15H2,1-4H3/t18-,20+/m0/s1
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n/an/a 63.1n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506523
PNG
(US11045457, Example 123)
Show SMILES CN1CC[C@H](NC(=O)C(C)(C)COc2ncccc2C2CC2)[C@@H](F)C1
Show InChI InChI=1S/C19H28FN3O2/c1-19(2,18(24)22-16-8-10-23(3)11-15(16)20)12-25-17-14(13-6-7-13)5-4-9-21-17/h4-5,9,13,15-16H,6-8,10-12H2,1-3H3,(H,22,24)/t15-,16-/m0/s1
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UniProtKB/SwissProt

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n/an/a 63.1n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506536
PNG
(US11045457, Example 136 | US11045457, Example 152)
Show SMILES C[C@H]1C[C@H](CCN1C)NC(=O)C(C)(C)COc1ncccc1OC(F)(F)F
Show InChI InChI=1S/C18H26F3N3O3/c1-12-10-13(7-9-24(12)4)23-16(25)17(2,3)11-26-15-14(6-5-8-22-15)27-18(19,20)21/h5-6,8,12-13H,7,9-11H2,1-4H3,(H,23,25)/t12-,13-/m0/s1
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n/an/a 79.4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
Somatostatin receptor type 4


(Homo sapiens (Human))
BDBM506527
PNG
(US11045457, Example 127)
Show SMILES CC[C@H]1CN(C)CC[C@@H]1NC(=O)C(C)(C)COc1ncccc1C
Show InChI InChI=1S/C19H31N3O2/c1-6-15-12-22(5)11-9-16(15)21-18(23)19(3,4)13-24-17-14(2)8-7-10-20-17/h7-8,10,15-16H,6,9,11-13H2,1-5H3,(H,21,23)/t15-,16-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 79.4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...


US Patent US11045457 (2021)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%