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Patent code US11046662

Compile Data Set for Download or QSAR
Found 48 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM506987
PNG
(4-hydroxy-2-(2-hydroxyphenyl)-N- methoxy-N-methyl-...)
Show SMILES CON(C)C(=O)c1sc(nc1O)-c1ccccc1O
Show InChI InChI=1S/C12H12N2O4S/c1-14(18-2)12(17)9-10(16)13-11(19-9)7-5-3-4-6-8(7)15/h3-6,15-16H,1-2H3
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n/an/a 6n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM506978
PNG
(2-(3-fluorophenyl)-4-hydroxy-N- methoxy-N-methyl-1...)
Show SMILES CON(C)C(=O)c1sc(nc1O)-c1cccc(F)c1
Show InChI InChI=1S/C12H11FN2O3S/c1-15(18-2)12(17)9-10(16)14-11(19-9)7-4-3-5-8(13)6-7/h3-6,16H,1-2H3
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n/an/a 18n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM507003
PNG
(1-[4-hydroxy-2-(3-hydroxyphenyl)- 1,3-thiazol-5-yl...)
Show SMILES CCC(=O)c1sc(nc1O)-c1cccc(O)c1
Show InChI InChI=1S/C12H11NO3S/c1-2-9(15)10-11(16)13-12(17-10)7-4-3-5-8(14)6-7/h3-6,14,16H,2H2,1H3
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n/an/a 23n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM506976
PNG
(Sodium 2-(3-fluorophenyl)-5- propanoyl-1,3-thiazol...)
Show SMILES CCC(=O)c1sc(nc1[O-])-c1cccc(F)c1
Show InChI InChI=1S/C12H10FNO2S/c1-2-9(15)10-11(16)14-12(17-10)7-4-3-5-8(13)6-7/h3-6,16H,2H2,1H3/p-1
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n/an/a 28n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM506977
PNG
(1-[2-(3-fluorophenyl)-4-hydroxy-1,3- thiazol-5-yl]...)
Show SMILES CCC(=O)c1sc(nc1O)-c1cccc(F)c1
Show InChI InChI=1S/C12H10FNO2S/c1-2-9(15)10-11(16)14-12(17-10)7-4-3-5-8(13)6-7/h3-6,16H,2H2,1H3
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n/an/a 32n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM507011
PNG
(1-[2-(4-fluorophenyl)-4-hydroxy-1,3- thiazol-5-yl]...)
Show SMILES CCC(=O)c1sc(nc1O)-c1ccc(F)cc1
Show InChI InChI=1S/C12H10FNO2S/c1-2-9(15)10-11(16)14-12(17-10)7-3-5-8(13)6-4-7/h3-6,16H,2H2,1H3
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n/an/a 50n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM506996
PNG
(1-[4-hydroxy-2-(thiophen-2-yl)-1,3- thiazol-5-yl]b...)
Show SMILES CCCC(=O)c1sc(nc1O)-c1cccs1
Show InChI InChI=1S/C11H11NO2S2/c1-2-4-7(13)9-10(14)12-11(16-9)8-5-3-6-15-8/h3,5-6,14H,2,4H2,1H3
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n/an/a 64n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM506997
PNG
(1-[4-hydroxy-2-(thiophen-2-yl)-1,3- thiazol-5-yl]-...)
Show SMILES CC(C)CC(=O)c1sc(nc1O)-c1cccs1
Show InChI InChI=1S/C12H13NO2S2/c1-7(2)6-8(14)10-11(15)13-12(17-10)9-4-3-5-16-9/h3-5,7,15H,6H2,1-2H3
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n/an/a 85n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM506983
PNG
(4-hydroxy-N-methoxy-N-methyl-2- (2-methylphenyl)-1...)
Show SMILES CON(C)C(=O)c1sc(nc1O)-c1ccccc1C
Show InChI InChI=1S/C13H14N2O3S/c1-8-6-4-5-7-9(8)12-14-11(16)10(19-12)13(17)15(2)18-3/h4-7,16H,1-3H3
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n/an/a 86n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM506995
PNG
(1-[4-hydroxy-2-(1-methyl-1H- pyrazol-4-yl)-1,3-thi...)
Show SMILES CCC(=O)c1sc(nc1O)-c1cnn(C)c1
Show InChI InChI=1S/C10H11N3O2S/c1-3-7(14)8-9(15)12-10(16-8)6-4-11-13(2)5-6/h4-5,15H,3H2,1-2H3
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DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM506998
PNG
(1-[4-hydroxy-2-(1,2,4-oxadiazol-3- yl)-1,3-thiazol...)
Show SMILES CCC(=O)c1sc(nc1O)-c1ncon1
Show InChI InChI=1S/C8H7N3O3S/c1-2-4(12)5-7(13)10-8(15-5)6-9-3-14-11-6/h3,13H,2H2,1H3
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DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM506988
PNG
(1-[2-(2-hydroxyphenyl)-4-hydroxy- 1,3-thiazol-5-yl...)
Show SMILES CCC(=O)c1sc(nc1O)-c1ccccc1O
Show InChI InChI=1S/C12H11NO3S/c1-2-8(14)10-11(16)13-12(17-10)7-5-3-4-6-9(7)15/h3-6,15-16H,2H2,1H3
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DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM506993
PNG
(1-[4-hydroxy-2-(1-methyl-1H- imidazol-5-yl)-1,3-th...)
Show SMILES CCC(=O)c1sc(nc1O)-c1cncn1C
Show InChI InChI=1S/C10H11N3O2S/c1-3-7(14)8-9(15)12-10(16-8)6-4-11-5-13(6)2/h4-5,15H,3H2,1-2H3
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DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM506991
PNG
(1-[4-hydroxy-2-(1H-pyrrol-2-yl)-1,3- thiazol-5-yl]...)
Show SMILES CCC(=O)c1sc(nc1O)-c1ccc[nH]1
Show InChI InChI=1S/C10H10N2O2S/c1-2-7(13)8-9(14)12-10(15-8)6-4-3-5-11-6/h3-5,11,14H,2H2,1H3
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DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM506999
PNG
(1-[4-hydroxy-2-(1,2-oxazol-5-yl)-1,3- thiazol-5-yl...)
Show SMILES CCC(=O)c1sc(nc1O)-c1ccno1
Show InChI InChI=1S/C9H8N2O3S/c1-2-5(12)7-8(13)11-9(15-7)6-3-4-10-14-6/h3-4,13H,2H2,1H3
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DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM507012
PNG
(1-(2-(3-fluorophenyl)-4- hydroxythiazol-5-yl)butan...)
Show SMILES CCCC(=O)c1sc(nc1O)-c1cccc(F)c1
Show InChI InChI=1S/C13H12FNO2S/c1-2-4-10(16)11-12(17)15-13(18-11)8-5-3-6-9(14)7-8/h3,5-7,17H,2,4H2,1H3
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DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM507002
PNG
(1-[4-hydroxy-2-(pyridin-2-yl)-1,3- thiazol-5-yl]pr...)
Show SMILES CCC(=O)c1sc(nc1O)-c1ccccn1
Show InChI InChI=1S/C11H10N2O2S/c1-2-8(14)9-10(15)13-11(16-9)7-5-3-4-6-12-7/h3-6,15H,2H2,1H3
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DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM506981
PNG
(4-hydroxy-N-methoxy-N-methyl-2- (thiophen-2-yl)-1,...)
Show SMILES CON(C)C(=O)c1sc(nc1O)-c1cccs1
Show InChI InChI=1S/C10H10N2O3S2/c1-12(15-2)10(14)7-8(13)11-9(17-7)6-4-3-5-16-6/h3-5,13H,1-2H3
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DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM507005
PNG
(1-[4-hydroxy-2-(3-methylphenyl)- 1,3-thiazol-5-yl]...)
Show SMILES CCC(=O)c1sc(nc1O)-c1cccc(C)c1
Show InChI InChI=1S/C13H13NO2S/c1-3-10(15)11-12(16)14-13(17-11)9-6-4-5-8(2)7-9/h4-7,16H,3H2,1-2H3
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n/an/a 231n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM507009
PNG
(1-{4-hydroxy-2-[3- (methylamino)phenyl]-1,3-thiazo...)
Show SMILES CCC(=O)c1sc(nc1O)-c1cccc(NC)c1
Show InChI InChI=1S/C13H14N2O2S/c1-3-10(16)11-12(17)15-13(18-11)8-5-4-6-9(7-8)14-2/h4-7,14,17H,3H2,1-2H3
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DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM507015
PNG
(1-[2-(3-fluorophenyl)-4-hydroxy-1,3- thiazol-5-yl]...)
Show SMILES CCC(=S)c1sc(nc1O)-c1cccc(F)c1
Show InChI InChI=1S/C12H10FNOS2/c1-2-9(16)10-11(15)14-12(17-10)7-4-3-5-8(13)6-7/h3-6,15H,2H2,1H3
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DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM506990
PNG
(1-[2-(furan-2-yl)-4-hydroxy-1,3- thiazol-5-yl]prop...)
Show SMILES CCC(=O)c1sc(nc1O)-c1ccco1
Show InChI InChI=1S/C10H9NO3S/c1-2-6(12)8-9(13)11-10(15-8)7-4-3-5-14-7/h3-5,13H,2H2,1H3
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DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM507006
PNG
(1-[4-hydroxy-2-(4-methylphenyl)- 1,3-thiazol-5-yl]...)
Show SMILES CCC(=O)c1sc(nc1O)-c1ccc(C)cc1
Show InChI InChI=1S/C13H13NO2S/c1-3-10(15)11-12(16)14-13(17-11)9-6-4-8(2)5-7-9/h4-7,16H,3H2,1-2H3
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DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM507020
PNG
(US11046662, Compound 45 | cyclopropyl[2-(3-fluorop...)
Show SMILES Oc1nc(sc1C(=O)C1CC1)-c1cccc(F)c1
Show InChI InChI=1S/C13H10FNO2S/c14-9-3-1-2-8(6-9)13-15-12(17)11(18-13)10(16)7-4-5-7/h1-3,6-7,17H,4-5H2
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DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM506980
PNG
(1-[2-(3-fluorophenyl)-4-hydroxy-1,3- thiazol-5-yl]...)
Show SMILES CC(C)C(=O)c1sc(nc1O)-c1cccc(F)c1
Show InChI InChI=1S/C13H12FNO2S/c1-7(2)10(16)11-12(17)15-13(18-11)8-4-3-5-9(14)6-8/h3-7,17H,1-2H3
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n/an/a 299n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM506994
PNG
(1-[4-hydroxy-2-(1H-imidazol-5-yl)- 1,3-thiazol-5-y...)
Show SMILES CCC(=O)c1sc(nc1O)-c1cnc[nH]1
Show InChI InChI=1S/C9H9N3O2S/c1-2-6(13)7-8(14)12-9(15-7)5-3-10-4-11-5/h3-4,14H,2H2,1H3,(H,10,11)
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n/an/a 302n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM506992
PNG
(1-[4-hydroxy-2-(1-methyl-1H-pyrrol- 2-yl)-1,3-thia...)
Show SMILES CCC(=O)c1sc(nc1O)-c1cccn1C
Show InChI InChI=1S/C11H12N2O2S/c1-3-8(14)9-10(15)12-11(16-9)7-5-4-6-13(7)2/h4-6,15H,3H2,1-2H3
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n/an/a 323n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM507004
PNG
(1-[4-hydroxy-2-(4-hydroxyphenyl)- 1,3-thiazol-5-yl...)
Show SMILES CCC(=O)c1sc(nc1O)-c1ccc(O)cc1
Show InChI InChI=1S/C12H11NO3S/c1-2-9(15)10-11(16)13-12(17-10)7-3-5-8(14)6-4-7/h3-6,14,16H,2H2,1H3
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n/an/a 326n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM507013
PNG
(1-(2-(3-fluorophenyl)-4- hydroxythiazol-5-yl)isobu...)
Show SMILES CC(C)CC(=O)c1sc(nc1O)-c1cccc(F)c1
Show InChI InChI=1S/C14H14FNO2S/c1-8(2)6-11(17)12-13(18)16-14(19-12)9-4-3-5-10(15)7-9/h3-5,7-8,18H,6H2,1-2H3
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n/an/a 331n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM507000
PNG
(1-[4-hydroxy-2-(pyridin-3-yl)-1,3- thiazol-5-yl]pr...)
Show SMILES CCC(=O)c1sc(nc1O)-c1cccnc1
Show InChI InChI=1S/C11H10N2O2S/c1-2-8(14)9-10(15)13-11(16-9)7-4-3-5-12-6-7/h3-6,15H,2H2,1H3
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n/an/a 356n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM507016
PNG
(2-(3-fluorophenyl)-4-hydroxy-N- methoxy-N-methyl-1...)
Show SMILES CON(C)C(=S)c1sc(nc1O)-c1cccc(F)c1
Show InChI InChI=1S/C12H11FN2O2S2/c1-15(17-2)12(18)9-10(16)14-11(19-9)7-4-3-5-8(13)6-7/h3-6,16H,1-2H3
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n/an/a 388n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM506984
PNG
(1-[4-hydroxy-2-(2-methylphenyl)- 1,3-thiazol-5-yl]...)
Show SMILES CCC(=O)c1sc(nc1O)-c1ccccc1C
Show InChI InChI=1S/C13H13NO2S/c1-3-10(15)11-12(16)14-13(17-11)9-7-5-4-6-8(9)2/h4-7,16H,3H2,1-2H3
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n/an/a 411n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM506985
PNG
(2-(2-bromophenyl)-4-hydroxy-N- methoxy-N-methyl-1,...)
Show SMILES CON(C)C(=O)c1sc(nc1O)-c1ccccc1Br
Show InChI InChI=1S/C12H11BrN2O3S/c1-15(18-2)12(17)9-10(16)14-11(19-9)7-5-3-4-6-8(7)13/h3-6,16H,1-2H3
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n/an/a 435n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM507007
PNG
(1-[2-(3-aminophenyl)-4-hydroxy-1,3- thiazol-5-yl]p...)
Show SMILES CCC(=O)c1sc(nc1O)-c1cccc(N)c1
Show InChI InChI=1S/C12H12N2O2S/c1-2-9(15)10-11(16)14-12(17-10)7-4-3-5-8(13)6-7/h3-6,16H,2,13H2,1H3
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n/an/a 450n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM507001
PNG
(1-[4-hydroxy-2-(pyridin-4-yl)-1,3- thiazol-5-yl]pr...)
Show SMILES CCC(=O)c1sc(nc1O)-c1ccncc1
Show InChI InChI=1S/C11H10N2O2S/c1-2-8(14)9-10(15)13-11(16-9)7-3-5-12-6-4-7/h3-6,15H,2H2,1H3
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n/an/a 453n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM507014
PNG
(1-[2-(3-fluorophenyl)-4-hydroxy-1,3- thiazol-5-yl]...)
Show SMILES COCC(=O)c1sc(nc1O)-c1cccc(F)c1
Show InChI InChI=1S/C12H10FNO3S/c1-17-6-9(15)10-11(16)14-12(18-10)7-3-2-4-8(13)5-7/h2-5,16H,6H2,1H3
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n/an/a 523n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM506982
PNG
(1-[4-hydroxy-2-(thiophen-2-yl)-1,3- thiazol-5-yl]p...)
Show SMILES CCC(=O)c1sc(nc1O)-c1cccs1
Show InChI InChI=1S/C10H9NO2S2/c1-2-6(12)8-9(13)11-10(15-8)7-4-3-5-14-7/h3-5,13H,2H2,1H3
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n/an/a 596n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM507008
PNG
(1-[2-(4-am inophenyl)-4-hydroxy- 1,3-thiazol-5-yl]...)
Show SMILES CCC(=O)c1sc(nc1O)-c1ccc(N)cc1
Show InChI InChI=1S/C12H12N2O2S/c1-2-9(15)10-11(16)14-12(17-10)7-3-5-8(13)6-4-7/h3-6,16H,2,13H2,1H3
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n/an/a 632n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM507010
PNG
(1-{4-hydroxy-2-[4- (methylamino)phenyl]-1,3-thiazo...)
Show SMILES CCC(=O)c1sc(nc1O)-c1ccc(NC)cc1
Show InChI InChI=1S/C13H14N2O2S/c1-3-10(16)11-12(17)15-13(18-11)8-4-6-9(14-2)7-5-8/h4-7,14,17H,3H2,1-2H3
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n/an/a 789n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM506986
PNG
(1-[2-(2-bromophenyl)-4-hydroxy-1,3- thiazol-5-yl]p...)
Show SMILES CCC(=O)c1sc(nc1O)-c1ccccc1Br
Show InChI InChI=1S/C12H10BrNO2S/c1-2-9(15)10-11(16)14-12(17-10)7-5-3-4-6-8(7)13/h3-6,16H,2H2,1H3
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n/an/a 912n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM506979
PNG
(1-(2-(3-fluorophenyl)-4- hydroxythiazol-5-yl)ethan...)
Show SMILES CC(=O)c1sc(nc1O)-c1cccc(F)c1
Show InChI InChI=1S/C11H8FNO2S/c1-6(14)9-10(15)13-11(16-9)7-3-2-4-8(12)5-7/h2-5,15H,1H3
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n/an/a 958n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM507017
PNG
(2-(3-fluorophenyl)-5-[(1E)-N- methoxypropanimidoyl...)
Show SMILES CC\C(=N/OC)c1sc(nc1O)-c1cccc(F)c1
Show InChI InChI=1S/C13H13FN2O2S/c1-3-10(16-18-2)11-12(17)15-13(19-11)8-5-4-6-9(14)7-8/h4-7,17H,3H2,1-2H3/b16-10+
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n/an/a 986n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM507018
PNG
(2-(3-fluorophenyl)-5-propanimidoyl- 1,3-thiazol-4-...)
Show SMILES CCC(=N)c1sc(nc1O)-c1cccc(F)c1
Show InChI InChI=1S/C12H11FN2OS/c1-2-9(14)10-11(16)15-12(17-10)7-4-3-5-8(13)6-7/h3-6,14,16H,2H2,1H3
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n/an/a 1.21E+3n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM507019
PNG
(2-(3-fluorophenyl)-5-[(1E)-N- hydroxypropanimidoyl...)
Show SMILES CC\C(=N/O)c1sc(nc1O)-c1cccc(F)c1
Show InChI InChI=1S/C12H11FN2O2S/c1-2-9(15-17)10-11(16)14-12(18-10)7-4-3-5-8(13)6-7/h3-6,16-17H,2H2,1H3/b15-9+
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n/an/a 1.36E+3n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))
BDBM506989
PNG
(1-[2-(3-bromophenyl)-4-hydroxy-1,3- thiazol-5-yl]p...)
Show SMILES CCC(=O)c1sc(nc1O)-c1cccc(Br)c1
Show InChI InChI=1S/C12H10BrNO2S/c1-2-9(15)10-11(16)14-12(17-10)7-4-3-5-8(13)6-7/h3-6,16H,2H2,1H3
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n/an/a 1.73E+3n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))
BDBM506976
PNG
(Sodium 2-(3-fluorophenyl)-5- propanoyl-1,3-thiazol...)
Show SMILES CCC(=O)c1sc(nc1[O-])-c1cccc(F)c1
Show InChI InChI=1S/C12H10FNO2S/c1-2-9(15)10-11(16)14-12(17-10)7-4-3-5-8(13)6-7/h3-6,16H,2H2,1H3/p-1
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent


Assay Description
a. Cloning, Sequencing, Transfection and Selection of Positive Clones Expressing Human TRPM8A functional cell-based assay for the identification of T...


US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Vanilloid receptor


(Homo sapiens (Human))
BDBM506976
PNG
(Sodium 2-(3-fluorophenyl)-5- propanoyl-1,3-thiazol...)
Show SMILES CCC(=O)c1sc(nc1[O-])-c1cccc(F)c1
Show InChI InChI=1S/C12H10FNO2S/c1-2-9(15)10-11(16)14-12(17-10)7-4-3-5-8(13)6-7/h3-6,16H,2H2,1H3/p-1
PDB
MMDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent


Assay Description
In order to address more specifically the potential selectivity issues, a counterassay was carried out for compound 2 against TRPV1 and TRPV4 ion cha...


US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM506976
PNG
(Sodium 2-(3-fluorophenyl)-5- propanoyl-1,3-thiazol...)
Show SMILES CCC(=O)c1sc(nc1[O-])-c1cccc(F)c1
Show InChI InChI=1S/C12H10FNO2S/c1-2-9(15)10-11(16)14-12(17-10)7-4-3-5-8(13)6-7/h3-6,16H,2H2,1H3/p-1
PDB

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n/an/a>1.00E+4n/an/an/an/an/an/a



DOMPÉ FARMACEUTICI S.P.A.

US Patent




US Patent US11046662 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%