Compile Data Set for Download or QSAR
maximum 50k data
Found 48 Enz. Inhib. hit(s) with all data for entry = 10001
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM506987(4-hydroxy-2-(2-hydroxyphenyl)-N- methoxy-N-methyl-...)
Affinity DataIC50:  6nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM506978(2-(3-fluorophenyl)-4-hydroxy-N- methoxy-N-methyl-1...)
Affinity DataIC50:  18nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM507003(1-[4-hydroxy-2-(3-hydroxyphenyl)- 1,3-thiazol-5-yl...)
Affinity DataIC50:  23nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM506976(Sodium 2-(3-fluorophenyl)-5- propanoyl-1,3-thiazol...)
Affinity DataIC50:  28nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM506977(1-[2-(3-fluorophenyl)-4-hydroxy-1,3- thiazol-5-yl]...)
Affinity DataIC50:  32nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM507011(1-[2-(4-fluorophenyl)-4-hydroxy-1,3- thiazol-5-yl]...)
Affinity DataIC50:  50nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM506996(1-[4-hydroxy-2-(thiophen-2-yl)-1,3- thiazol-5-yl]b...)
Affinity DataIC50:  64nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM506997(1-[4-hydroxy-2-(thiophen-2-yl)-1,3- thiazol-5-yl]-...)
Affinity DataIC50:  85nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM506983(4-hydroxy-N-methoxy-N-methyl-2- (2-methylphenyl)-1...)
Affinity DataIC50:  86nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM506995(1-[4-hydroxy-2-(1-methyl-1H- pyrazol-4-yl)-1,3-thi...)
Affinity DataIC50:  89nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM506998(1-[4-hydroxy-2-(1,2,4-oxadiazol-3- yl)-1,3-thiazol...)
Affinity DataIC50:  99nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM506993(1-[4-hydroxy-2-(1-methyl-1H- imidazol-5-yl)-1,3-th...)
Affinity DataIC50:  112nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM506988(1-[2-(2-hydroxyphenyl)-4-hydroxy- 1,3-thiazol-5-yl...)
Affinity DataIC50:  112nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM506999(1-[4-hydroxy-2-(1,2-oxazol-5-yl)-1,3- thiazol-5-yl...)
Affinity DataIC50:  123nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM506991(1-[4-hydroxy-2-(1H-pyrrol-2-yl)-1,3- thiazol-5-yl]...)
Affinity DataIC50:  123nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM507012(1-(2-(3-fluorophenyl)-4- hydroxythiazol-5-yl)butan...)
Affinity DataIC50:  142nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM507002(1-[4-hydroxy-2-(pyridin-2-yl)-1,3- thiazol-5-yl]pr...)
Affinity DataIC50:  145nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM506981(4-hydroxy-N-methoxy-N-methyl-2- (thiophen-2-yl)-1,...)
Affinity DataIC50:  156nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM507005(1-[4-hydroxy-2-(3-methylphenyl)- 1,3-thiazol-5-yl]...)
Affinity DataIC50:  231nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM507009(1-{4-hydroxy-2-[3- (methylamino)phenyl]-1,3-thiazo...)
Affinity DataIC50:  233nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM507015(1-[2-(3-fluorophenyl)-4-hydroxy-1,3- thiazol-5-yl]...)
Affinity DataIC50:  236nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM507006(1-[4-hydroxy-2-(4-methylphenyl)- 1,3-thiazol-5-yl]...)
Affinity DataIC50:  236nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM506990(1-[2-(furan-2-yl)-4-hydroxy-1,3- thiazol-5-yl]prop...)
Affinity DataIC50:  236nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM507020(US11046662, Compound 45 | cyclopropyl[2-(3-fluorop...)
Affinity DataIC50:  287nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM506980(1-[2-(3-fluorophenyl)-4-hydroxy-1,3- thiazol-5-yl]...)
Affinity DataIC50:  299nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM506994(1-[4-hydroxy-2-(1H-imidazol-5-yl)- 1,3-thiazol-5-y...)
Affinity DataIC50:  302nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM506992(1-[4-hydroxy-2-(1-methyl-1H-pyrrol- 2-yl)-1,3-thia...)
Affinity DataIC50:  323nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM507004(1-[4-hydroxy-2-(4-hydroxyphenyl)- 1,3-thiazol-5-yl...)
Affinity DataIC50:  326nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM507013(1-(2-(3-fluorophenyl)-4- hydroxythiazol-5-yl)isobu...)
Affinity DataIC50:  331nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM507000(1-[4-hydroxy-2-(pyridin-3-yl)-1,3- thiazol-5-yl]pr...)
Affinity DataIC50:  356nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM507016(2-(3-fluorophenyl)-4-hydroxy-N- methoxy-N-methyl-1...)
Affinity DataIC50:  388nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM506984(1-[4-hydroxy-2-(2-methylphenyl)- 1,3-thiazol-5-yl]...)
Affinity DataIC50:  411nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM506985(2-(2-bromophenyl)-4-hydroxy-N- methoxy-N-methyl-1,...)
Affinity DataIC50:  435nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM507007(1-[2-(3-aminophenyl)-4-hydroxy-1,3- thiazol-5-yl]p...)
Affinity DataIC50:  450nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM507001(1-[4-hydroxy-2-(pyridin-4-yl)-1,3- thiazol-5-yl]pr...)
Affinity DataIC50:  453nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM507014(1-[2-(3-fluorophenyl)-4-hydroxy-1,3- thiazol-5-yl]...)
Affinity DataIC50:  523nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM506982(1-[4-hydroxy-2-(thiophen-2-yl)-1,3- thiazol-5-yl]p...)
Affinity DataIC50:  596nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM507008(1-[2-(4-am inophenyl)-4-hydroxy- 1,3-thiazol-5-yl]...)
Affinity DataIC50:  632nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM507010(1-{4-hydroxy-2-[4- (methylamino)phenyl]-1,3-thiazo...)
Affinity DataIC50:  789nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM506986(1-[2-(2-bromophenyl)-4-hydroxy-1,3- thiazol-5-yl]p...)
Affinity DataIC50:  912nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM506979(1-(2-(3-fluorophenyl)-4- hydroxythiazol-5-yl)ethan...)
Affinity DataIC50:  958nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM507017(2-(3-fluorophenyl)-5-[(1E)-N- methoxypropanimidoyl...)
Affinity DataIC50:  986nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM507018(2-(3-fluorophenyl)-5-propanimidoyl- 1,3-thiazol-4-...)
Affinity DataIC50:  1.21E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM507019(2-(3-fluorophenyl)-5-[(1E)-N- hydroxypropanimidoyl...)
Affinity DataIC50:  1.36E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM506989(1-[2-(3-bromophenyl)-4-hydroxy-1,3- thiazol-5-yl]p...)
Affinity DataIC50:  1.73E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM506976(Sodium 2-(3-fluorophenyl)-5- propanoyl-1,3-thiazol...)
Affinity DataIC50: >1.00E+4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM506976(Sodium 2-(3-fluorophenyl)-5- propanoyl-1,3-thiazol...)
Affinity DataIC50: >1.00E+4nMAssay Description:In order to address more specifically the potential selectivity issues, a counterassay was carried out for compound 2 against TRPV1 and TRPV4 ion cha...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily V member 4(Homo sapiens (Human))
DompÉ

US Patent
LigandPNGBDBM506976(Sodium 2-(3-fluorophenyl)-5- propanoyl-1,3-thiazol...)
Affinity DataIC50: >1.00E+4nMAssay Description:a. Cloning, Sequencing, Transfection and Selection of Positive Clones Expressing Human TRPM8A functional cell-based assay for the identification of T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent