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Patent code US11046672

Compile Data Set for Download or QSAR

Found 414 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50026612
PNG
(BIBF-1120 | NINTEDANIB | Nintedanib | US10981896, ...)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-
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3.80n/an/an/an/an/an/an/an/a



RespiVert Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM507109
PNG
(US11046672, Example 58)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)OCCN3CCN(CCO)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C34H39N5O6/c1-23-21-28-29(22-27(23)34(43)44-3)36-32(41)30(28)31(24-7-5-4-6-8-24)35-26-11-9-25(10-12-26)33(42)37(2)45-20-18-39-15-13-38(14-16-39)17-19-40/h4-12,21-22,35,40H,13-20H2,1-3H3,(H,36,41)/b31-30-
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3.86n/an/an/an/an/an/an/an/a



RespiVert Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM507056
PNG
((Z)-Methyl 3-(((4-((2-(dimethylamino)ethoxy)carbam...)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(C(=O)NOCCN(C)C)c(C)c3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C30H32N4O5/c1-18-15-21(11-12-22(18)28(35)33-39-14-13-34(3)4)31-27(20-9-7-6-8-10-20)26-24-16-19(2)23(30(37)38-5)17-25(24)32-29(26)36/h6-12,15-17,31H,13-14H2,1-5H3,(H,32,36)(H,33,35)/b27-26-
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4.57n/an/an/an/an/an/an/an/a



RespiVert Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
VHL/PDGFRB


(Homo sapiens (Human))
BDBM507078
PNG
(US11046672, Example 27)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NOCCCN(C)C)c3ccccc3)c2cc1C
Show InChI InChI=1S/C30H32N4O5/c1-19-17-24-25(18-23(19)30(37)38-4)32-29(36)26(24)27(20-9-6-5-7-10-20)31-22-13-11-21(12-14-22)28(35)33-39-16-8-15-34(2)3/h5-7,9-14,17-18,31H,8,15-16H2,1-4H3,(H,32,36)(H,33,35)/b27-26-
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4.77n/an/an/an/an/an/an/an/a



RespiVert Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
VHL/PDGFRB


(Homo sapiens (Human))
BDBM507083
PNG
(US11046672, Example 32)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(C(=O)NOCCN4CCN(C)CC4)c(F)c3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C32H34FN5O5/c1-20-17-25-27(19-24(20)32(41)42-3)35-31(40)28(25)29(21-7-5-4-6-8-21)34-22-9-10-23(26(33)18-22)30(39)36-43-16-15-38-13-11-37(2)12-14-38/h4-10,17-19,34H,11-16H2,1-3H3,(H,35,40)(H,36,39)/b29-28-
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Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM507111
PNG
(US11046672, Example 60)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)OCCN3C4CCC3CNC4)c3ccccc3)c2cc1C
Show InChI InChI=1S/C34H37N5O5/c1-21-17-28-29(18-27(21)34(42)43-3)37-32(40)30(28)31(22-7-5-4-6-8-22)36-24-11-9-23(10-12-24)33(41)38(2)44-16-15-39-25-13-14-26(39)20-35-19-25/h4-12,17-18,25-26,35-36H,13-16,19-20H2,1-3H3,(H,37,40)/b31-30-
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5.24n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM507108
PNG
(US11046672, Example 57)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)OCCN3CCNCC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C32H35N5O5/c1-21-19-26-27(20-25(21)32(40)41-3)35-30(38)28(26)29(22-7-5-4-6-8-22)34-24-11-9-23(10-12-24)31(39)36(2)42-18-17-37-15-13-33-14-16-37/h4-12,19-20,33-34H,13-18H2,1-3H3,(H,35,38)/b29-28-
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5.36n/an/an/an/an/an/an/an/a



RespiVert Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
VHL/PDGFRB


(Homo sapiens (Human))
BDBM507090
PNG
(US11046672, Example 39)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)C(=O)NOCCN3CCN(CCO)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C32H35N5O6/c1-42-32(41)24-9-12-26-27(21-24)34-31(40)28(26)29(22-5-3-2-4-6-22)33-25-10-7-23(8-11-25)30(39)35-43-20-18-37-15-13-36(14-16-37)17-19-38/h2-12,21,33,38H,13-20H2,1H3,(H,34,40)(H,35,39)/b29-28-
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5.39n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM507110
PNG
(US11046672, Example 59)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)OCCN3C[C@@H]4C[C@H]3CN4)c3ccccc3)c2cc1C
Show InChI InChI=1S/C33H35N5O5/c1-20-15-27-28(17-26(20)33(41)42-3)36-31(39)29(27)30(21-7-5-4-6-8-21)35-23-11-9-22(10-12-23)32(40)37(2)43-14-13-38-19-24-16-25(38)18-34-24/h4-12,15,17,24-25,34-35H,13-14,16,18-19H2,1-3H3,(H,36,39)/b30-29-/t24-,25-/m0/s1
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM507113
PNG
(US11046672, Example 62)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)OCCN3CCN[C@@H](C)C3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C33H37N5O5/c1-21-18-27-28(19-26(21)33(41)42-4)36-31(39)29(27)30(23-8-6-5-7-9-23)35-25-12-10-24(11-13-25)32(40)37(3)43-17-16-38-15-14-34-22(2)20-38/h5-13,18-19,22,34-35H,14-17,20H2,1-4H3,(H,36,39)/b30-29-/t22-/m0/s1
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Assay Description
The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM50026612
PNG
(BIBF-1120 | NINTEDANIB | Nintedanib | US10981896, ...)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-
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5.90n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM507116
PNG
(US11046672, Example 66)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)OCCN3CC4CC(C3)N4)c3ccccc3)c2cc1C
Show InChI InChI=1S/C33H35N5O5/c1-20-15-27-28(17-26(20)33(41)42-3)36-31(39)29(27)30(21-7-5-4-6-8-21)35-23-11-9-22(10-12-23)32(40)37(2)43-14-13-38-18-24-16-25(19-38)34-24/h4-12,15,17,24-25,34-35H,13-14,16,18-19H2,1-3H3,(H,36,39)/b30-29-
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
VHL/PDGFRB


(Homo sapiens (Human))
BDBM507082
PNG
(US11046672, Example 31)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(C(=O)NOC4CCN(C)CC4)c(C)c3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C32H34N4O5/c1-19-16-22(10-11-24(19)30(37)35-41-23-12-14-36(3)15-13-23)33-29(21-8-6-5-7-9-21)28-26-17-20(2)25(32(39)40-4)18-27(26)34-31(28)38/h5-11,16-18,23,33H,12-15H2,1-4H3,(H,34,38)(H,35,37)/b29-28-
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6.58n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
VHL/PDGFRB


(Homo sapiens (Human))
BDBM507058
PNG
((Z)-Methyl 3-(((4-((2-(4-(2-hydroxyethyl)piperazin...)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NOCCN3CCN(CCO)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C33H37N5O6/c1-22-20-27-28(21-26(22)33(42)43-2)35-32(41)29(27)30(23-6-4-3-5-7-23)34-25-10-8-24(9-11-25)31(40)36-44-19-17-38-14-12-37(13-15-38)16-18-39/h3-11,20-21,34,39H,12-19H2,1-2H3,(H,35,41)(H,36,40)/b30-29-
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM507090
PNG
(US11046672, Example 39)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)C(=O)NOCCN3CCN(CCO)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C32H35N5O6/c1-42-32(41)24-9-12-26-27(21-24)34-31(40)28(26)29(22-5-3-2-4-6-22)33-25-10-7-23(8-11-25)30(39)35-43-20-18-37-15-13-36(14-16-37)17-19-38/h2-12,21,33,38H,13-20H2,1H3,(H,34,40)(H,35,39)/b29-28-
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM507056
PNG
((Z)-Methyl 3-(((4-((2-(dimethylamino)ethoxy)carbam...)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(C(=O)NOCCN(C)C)c(C)c3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C30H32N4O5/c1-18-15-21(11-12-22(18)28(35)33-39-14-13-34(3)4)31-27(20-9-7-6-8-10-20)26-24-16-19(2)23(30(37)38-5)17-25(24)32-29(26)36/h6-12,15-17,31H,13-14H2,1-5H3,(H,32,36)(H,33,35)/b27-26-
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Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM507113
PNG
(US11046672, Example 62)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)OCCN3CCN[C@@H](C)C3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C33H37N5O5/c1-21-18-27-28(19-26(21)33(41)42-4)36-31(39)29(27)30(23-8-6-5-7-9-23)35-25-12-10-24(11-13-25)32(40)37(3)43-17-16-38-15-14-34-22(2)20-38/h5-13,18-19,22,34-35H,14-17,20H2,1-4H3,(H,36,39)/b30-29-/t22-/m0/s1
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
VHL/PDGFRB


(Homo sapiens (Human))
BDBM507089
PNG
(US11046672, Example 38)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)C(=O)NOCCN3CC[C@@H](C3)N(C)C)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C32H35N5O5/c1-36(2)25-15-16-37(20-25)17-18-42-35-30(38)22-9-12-24(13-10-22)33-29(21-7-5-4-6-8-21)28-26-14-11-23(32(40)41-3)19-27(26)34-31(28)39/h4-14,19,25,33H,15-18,20H2,1-3H3,(H,34,39)(H,35,38)/b29-28-/t25-/m0/s1
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RespiVert Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
VHL/PDGFRB


(Homo sapiens (Human))
BDBM507093
PNG
(US11046672, Example 42)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)C(=O)NOCCN3CCNC(=O)C3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C30H29N5O6/c1-40-30(39)21-9-12-23-24(17-21)33-29(38)26(23)27(19-5-3-2-4-6-19)32-22-10-7-20(8-11-22)28(37)34-41-16-15-35-14-13-31-25(36)18-35/h2-12,17,32H,13-16,18H2,1H3,(H,31,36)(H,33,38)(H,34,37)/b27-26-
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM507090
PNG
(US11046672, Example 39)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)C(=O)NOCCN3CCN(CCO)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C32H35N5O6/c1-42-32(41)24-9-12-26-27(21-24)34-31(40)28(26)29(22-5-3-2-4-6-22)33-25-10-7-23(8-11-25)30(39)35-43-20-18-37-15-13-36(14-16-37)17-19-38/h2-12,21,33,38H,13-20H2,1H3,(H,34,40)(H,35,39)/b29-28-
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
VHL/PDGFRB


(Homo sapiens (Human))
BDBM507056
PNG
((Z)-Methyl 3-(((4-((2-(dimethylamino)ethoxy)carbam...)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(C(=O)NOCCN(C)C)c(C)c3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C30H32N4O5/c1-18-15-21(11-12-22(18)28(35)33-39-14-13-34(3)4)31-27(20-9-7-6-8-10-20)26-24-16-19(2)23(30(37)38-5)17-25(24)32-29(26)36/h6-12,15-17,31H,13-14H2,1-5H3,(H,32,36)(H,33,35)/b27-26-
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
VHL/PDGFRB


(Homo sapiens (Human))
BDBM507107
PNG
(US11046672, Example 56)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)OCCN(C)CCO)c3ccccc3)c2cc1C
Show InChI InChI=1S/C31H34N4O6/c1-20-18-25-26(19-24(20)31(39)40-4)33-29(37)27(25)28(21-8-6-5-7-9-21)32-23-12-10-22(11-13-23)30(38)35(3)41-17-15-34(2)14-16-36/h5-13,18-19,32,36H,14-17H2,1-4H3,(H,33,37)/b28-27-
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Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
VHL/PDGFRB


(Homo sapiens (Human))
BDBM507081
PNG
(US11046672, Example 30)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NOC3CCN(C)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C31H32N4O5/c1-19-17-25-26(18-24(19)31(38)39-3)33-30(37)27(25)28(20-7-5-4-6-8-20)32-22-11-9-21(10-12-22)29(36)34-40-23-13-15-35(2)16-14-23/h4-12,17-18,23,32H,13-16H2,1-3H3,(H,33,37)(H,34,36)/b28-27-
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM507069
PNG
(US11046672, Example 18)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(C(=O)N(C)OCCN4CCN(C)CC4)c(C)c3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C33H37N5O5/c1-22-20-25(11-13-26(22)32(40)37(3)43-19-18-38-16-14-36(2)15-17-38)34-30(23-8-6-5-7-9-23)29-27-12-10-24(33(41)42-4)21-28(27)35-31(29)39/h5-13,20-21,34H,14-19H2,1-4H3,(H,35,39)/b30-29-
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Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
VHL/PDGFRB


(Homo sapiens (Human))
BDBM507080
PNG
(US11046672, Example 29)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(C(=O)NOCCCN(C)C)c(C)c3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C31H34N4O5/c1-19-16-22(12-13-23(19)29(36)34-40-15-9-14-35(3)4)32-28(21-10-7-6-8-11-21)27-25-17-20(2)24(31(38)39-5)18-26(25)33-30(27)37/h6-8,10-13,16-18,32H,9,14-15H2,1-5H3,(H,33,37)(H,34,36)/b28-27-
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM507073
PNG
(US11046672, Example 22)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(C(=O)N(C)OCCN(C)C)c(C)c3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C30H32N4O5/c1-19-17-22(12-14-23(19)29(36)34(4)39-16-15-33(2)3)31-27(20-9-7-6-8-10-20)26-24-13-11-21(30(37)38-5)18-25(24)32-28(26)35/h6-14,17-18,31H,15-16H2,1-5H3,(H,32,35)/b27-26-
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
VHL/PDGFRB


(Homo sapiens (Human))
BDBM507091
PNG
(US11046672, Example 40)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)C(=O)NOCCN3CCC(O)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H32N4O6/c1-40-31(39)22-9-12-25-26(19-22)33-30(38)27(25)28(20-5-3-2-4-6-20)32-23-10-7-21(8-11-23)29(37)34-41-18-17-35-15-13-24(36)14-16-35/h2-12,19,24,32,36H,13-18H2,1H3,(H,33,38)(H,34,37)/b28-27-
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Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM507089
PNG
(US11046672, Example 38)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)C(=O)NOCCN3CC[C@@H](C3)N(C)C)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C32H35N5O5/c1-36(2)25-15-16-37(20-25)17-18-42-35-30(38)22-9-12-24(13-10-22)33-29(21-7-5-4-6-8-21)28-26-14-11-23(32(40)41-3)19-27(26)34-31(28)39/h4-14,19,25,33H,15-18,20H2,1-3H3,(H,34,39)(H,35,38)/b29-28-/t25-/m0/s1
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
VHL/PDGFRB


(Homo sapiens (Human))
BDBM507079
PNG
(US11046672, Example 28)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(C(=O)NOCCN4CCN(C)CC4)c(C)c3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C33H37N5O5/c1-21-18-24(10-11-25(21)31(39)36-43-17-16-38-14-12-37(3)13-15-38)34-30(23-8-6-5-7-9-23)29-27-19-22(2)26(33(41)42-4)20-28(27)35-32(29)40/h5-11,18-20,34H,12-17H2,1-4H3,(H,35,40)(H,36,39)/b30-29-
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Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM507122
PNG
(US11046672, Example 73)
Show SMILES CNC(=O)CN1CCN(CCONC(=O)c2ccc(N\C(=C3/C(=O)Nc4cc(C(=O)OC)c(C)cc34)c3ccccc3)cc2)CC1
Show InChI InChI=1S/C34H38N6O6/c1-22-19-27-28(20-26(22)34(44)45-3)37-33(43)30(27)31(23-7-5-4-6-8-23)36-25-11-9-24(10-12-25)32(42)38-46-18-17-39-13-15-40(16-14-39)21-29(41)35-2/h4-12,19-20,36H,13-18,21H2,1-3H3,(H,35,41)(H,37,43)(H,38,42)/b31-30-
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM507115
PNG
(US11046672, Example 65)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)OCCN3CCN[C@H](C)C3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C33H37N5O5/c1-21-18-27-28(19-26(21)33(41)42-4)36-31(39)29(27)30(23-8-6-5-7-9-23)35-25-12-10-24(11-13-25)32(40)37(3)43-17-16-38-15-14-34-22(2)20-38/h5-13,18-19,22,34-35H,14-17,20H2,1-4H3,(H,36,39)/b30-29-/t22-/m1/s1
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
VHL/PDGFRB


(Homo sapiens (Human))
BDBM507122
PNG
(US11046672, Example 73)
Show SMILES CNC(=O)CN1CCN(CCONC(=O)c2ccc(N\C(=C3/C(=O)Nc4cc(C(=O)OC)c(C)cc34)c3ccccc3)cc2)CC1
Show InChI InChI=1S/C34H38N6O6/c1-22-19-27-28(20-26(22)34(44)45-3)37-33(43)30(27)31(23-7-5-4-6-8-23)36-25-11-9-24(10-12-25)32(42)38-46-18-17-39-13-15-40(16-14-39)21-29(41)35-2/h4-12,19-20,36H,13-18,21H2,1-3H3,(H,35,41)(H,37,43)(H,38,42)/b31-30-
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
VHL/PDGFRB


(Homo sapiens (Human))
BDBM50026612
PNG
(BIBF-1120 | NINTEDANIB | Nintedanib | US10981896, ...)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM507073
PNG
(US11046672, Example 22)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(C(=O)N(C)OCCN(C)C)c(C)c3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C30H32N4O5/c1-19-17-22(12-14-23(19)29(36)34(4)39-16-15-33(2)3)31-27(20-9-7-6-8-10-20)26-24-13-11-21(30(37)38-5)18-25(24)32-28(26)35/h6-14,17-18,31H,15-16H2,1-5H3,(H,32,35)/b27-26-
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
VHL/PDGFRB


(Homo sapiens (Human))
BDBM507057
PNG
((Z)-Methyl 5-methyl-3-(((4-((2-(4-methylpiperazin-...)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NOCCN3CCN(C)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C32H35N5O5/c1-21-19-26-27(20-25(21)32(40)41-3)34-31(39)28(26)29(22-7-5-4-6-8-22)33-24-11-9-23(10-12-24)30(38)35-42-18-17-37-15-13-36(2)14-16-37/h4-12,19-20,33H,13-18H2,1-3H3,(H,34,39)(H,35,38)/b29-28-
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM507054
PNG
((Z)-Methyl 3-(((4-((2-(dimethylamino)ethoxy)carbam...)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)C(=O)NOCCN(C)C)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C28H28N4O5/c1-32(2)15-16-37-31-26(33)19-9-12-21(13-10-19)29-25(18-7-5-4-6-8-18)24-22-14-11-20(28(35)36-3)17-23(22)30-27(24)34/h4-14,17,29H,15-16H2,1-3H3,(H,30,34)(H,31,33)/b25-24-
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM50026612
PNG
(BIBF-1120 | NINTEDANIB | Nintedanib | US10981896, ...)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-
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US Patent


Assay Description
The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
VHL/PDGFRB


(Homo sapiens (Human))
BDBM507087
PNG
(US11046672, Example 36)
Show SMILES CCN1CCN(CCONC(=O)c2ccc(N\C(=C3/C(=O)Nc4cc(C(=O)OC)c(C)cc34)c3ccccc3)cc2)CC1
Show InChI InChI=1S/C33H37N5O5/c1-4-37-14-16-38(17-15-37)18-19-43-36-31(39)24-10-12-25(13-11-24)34-30(23-8-6-5-7-9-23)29-27-20-22(2)26(33(41)42-3)21-28(27)35-32(29)40/h5-13,20-21,34H,4,14-19H2,1-3H3,(H,35,40)(H,36,39)/b30-29-
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8.46n/an/an/an/an/an/an/an/a



RespiVert Limited

US Patent


Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
VHL/PDGFRB


(Homo sapiens (Human))
BDBM507084
PNG
(US11046672, Example 33)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(C(=O)NOCCN4CCN(C)CC4)c(F)c3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H32FN5O5/c1-36-12-14-37(15-13-36)16-17-42-35-29(38)23-11-9-22(19-25(23)32)33-28(20-6-4-3-5-7-20)27-24-10-8-21(31(40)41-2)18-26(24)34-30(27)39/h3-11,18-19,33H,12-17H2,1-2H3,(H,34,39)(H,35,38)/b28-27-
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8.47n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
VHL/PDGFRB


(Homo sapiens (Human))
BDBM507077
PNG
(US11046672, Example 26)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NOCCN(C)C)c3ccccc3)c2cc1C
Show InChI InChI=1S/C29H30N4O5/c1-18-16-23-24(17-22(18)29(36)37-4)31-28(35)25(23)26(19-8-6-5-7-9-19)30-21-12-10-20(11-13-21)27(34)32-38-15-14-33(2)3/h5-13,16-17,30H,14-15H2,1-4H3,(H,31,35)(H,32,34)/b26-25-
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8.61n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM507054
PNG
((Z)-Methyl 3-(((4-((2-(dimethylamino)ethoxy)carbam...)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)C(=O)NOCCN(C)C)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C28H28N4O5/c1-32(2)15-16-37-31-26(33)19-9-12-21(13-10-19)29-25(18-7-5-4-6-8-18)24-22-14-11-20(28(35)36-3)17-23(22)30-27(24)34/h4-14,17,29H,15-16H2,1-3H3,(H,30,34)(H,31,33)/b25-24-
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8.65n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM507082
PNG
(US11046672, Example 31)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(C(=O)NOC4CCN(C)CC4)c(C)c3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C32H34N4O5/c1-19-16-22(10-11-24(19)30(37)35-41-23-12-14-36(3)15-13-23)33-29(21-8-6-5-7-9-21)28-26-17-20(2)25(32(39)40-4)18-27(26)34-31(28)38/h5-11,16-18,23,33H,12-15H2,1-4H3,(H,34,38)(H,35,37)/b29-28-
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8.74n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM507058
PNG
((Z)-Methyl 3-(((4-((2-(4-(2-hydroxyethyl)piperazin...)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NOCCN3CCN(CCO)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C33H37N5O6/c1-22-20-27-28(21-26(22)33(42)43-2)35-32(41)29(27)30(23-6-4-3-5-7-23)34-25-10-8-24(9-11-25)31(40)36-44-19-17-38-14-12-37(13-15-38)16-18-39/h3-11,20-21,34,39H,12-19H2,1-2H3,(H,35,41)(H,36,40)/b30-29-
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8.80n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM507057
PNG
((Z)-Methyl 5-methyl-3-(((4-((2-(4-methylpiperazin-...)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NOCCN3CCN(C)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C32H35N5O5/c1-21-19-26-27(20-25(21)32(40)41-3)34-31(39)28(26)29(22-7-5-4-6-8-22)33-24-11-9-23(10-12-24)30(38)35-42-18-17-37-15-13-36(2)14-16-37/h4-12,19-20,33H,13-18H2,1-3H3,(H,34,39)(H,35,38)/b29-28-
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8.80n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM507058
PNG
((Z)-Methyl 3-(((4-((2-(4-(2-hydroxyethyl)piperazin...)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NOCCN3CCN(CCO)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C33H37N5O6/c1-22-20-27-28(21-26(22)33(42)43-2)35-32(41)29(27)30(23-6-4-3-5-7-23)34-25-10-8-24(9-11-25)31(40)36-44-19-17-38-14-12-37(13-15-38)16-18-39/h3-11,20-21,34,39H,12-19H2,1-2H3,(H,35,41)(H,36,40)/b30-29-
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8.85n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
VHL/PDGFRB


(Homo sapiens (Human))
BDBM507109
PNG
(US11046672, Example 58)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)OCCN3CCN(CCO)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C34H39N5O6/c1-23-21-28-29(22-27(23)34(43)44-3)36-32(41)30(28)31(24-7-5-4-6-8-24)35-26-11-9-25(10-12-26)33(42)37(2)45-20-18-39-15-13-38(14-16-39)17-19-40/h4-12,21-22,35,40H,13-20H2,1-3H3,(H,36,41)/b31-30-
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8.87n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM507109
PNG
(US11046672, Example 58)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)OCCN3CCN(CCO)CC3)c3ccccc3)c2cc1C
Show InChI InChI=1S/C34H39N5O6/c1-23-21-28-29(22-27(23)34(43)44-3)36-32(41)30(28)31(24-7-5-4-6-8-24)35-26-11-9-25(10-12-26)33(42)37(2)45-20-18-39-15-13-38(14-16-39)17-19-40/h4-12,21-22,35,40H,13-20H2,1-3H3,(H,36,41)/b31-30-
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8.96n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM507078
PNG
(US11046672, Example 27)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NOCCCN(C)C)c3ccccc3)c2cc1C
Show InChI InChI=1S/C30H32N4O5/c1-19-17-24-25(18-23(19)30(37)38-4)32-29(36)26(24)27(20-9-6-5-7-10-20)31-22-13-11-21(12-14-22)28(35)33-39-16-8-15-34(2)3/h5-7,9-14,17-18,31H,8,15-16H2,1-4H3,(H,32,36)(H,33,35)/b27-26-
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9.11n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
VHL/PDGFRB


(Homo sapiens (Human))
BDBM507110
PNG
(US11046672, Example 59)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)OCCN3C[C@@H]4C[C@H]3CN4)c3ccccc3)c2cc1C
Show InChI InChI=1S/C33H35N5O5/c1-20-15-27-28(17-26(20)33(41)42-3)36-31(39)29(27)30(21-7-5-4-6-8-21)35-23-11-9-22(10-12-23)32(40)37(2)43-14-13-38-19-24-16-25(38)18-34-24/h4-12,15,17,24-25,34-35H,13-14,16,18-19H2,1-3H3,(H,36,39)/b30-29-/t24-,25-/m0/s1
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9.19n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
VHL/PDGFRB


(Homo sapiens (Human))
BDBM507101
PNG
(US11046672, Example 50)
Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NOCCN3CCC(CC3)N(C)C)c3ccccc3)c2cc1C
Show InChI InChI=1S/C34H39N5O5/c1-22-20-28-29(21-27(22)34(42)43-4)36-33(41)30(28)31(23-8-6-5-7-9-23)35-25-12-10-24(11-13-25)32(40)37-44-19-18-39-16-14-26(15-17-39)38(2)3/h5-13,20-21,26,35H,14-19H2,1-4H3,(H,36,41)(H,37,40)/b31-30-
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9.24n/an/an/an/an/an/an/an/a



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US Patent


Assay Description
The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...


US Patent US11046672 (2021)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%