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Patent code US11046680

Compile Data Set for Download or QSAR

Found 486 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Apelin receptor


(Homo sapiens (Human))
BDBM507134
PNG
(US11046680, Example 5.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2csc(C)n2)n1-c1c(OC)ncnc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C21H25N9O5S2/c1-11-7-22-17(23-8-11)16(33-4)12(2)37(31,32)29-21-28-27-18(14-9-36-13(3)26-14)30(21)15-19(34-5)24-10-25-20(15)35-6/h7-10,12,16H,1-6H3,(H,28,29)/t12-,16-/m0/s1
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n/an/an/an/a 4.10n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507146
PNG
(US11046680, Example 17.0)
Show SMILES COCC[C@H](Cc1ncc(C)cn1)S(=O)(=O)Nc1nnc(-c2nc(C)cs2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C24H29N7O5S2/c1-15-12-25-20(26-13-15)11-17(9-10-34-3)38(32,33)30-24-29-28-22(23-27-16(2)14-37-23)31(24)21-18(35-4)7-6-8-19(21)36-5/h6-8,12-14,17H,9-11H2,1-5H3,(H,29,30)/t17-/m1/s1
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n/an/an/an/a 5.20n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507148
PNG
(US11046680, Example 19.0 | US11046680, Example 20....)
Show SMILES COCC[C@H]([C@@H](C)c1ncc(F)cn1)S(=O)(=O)Nc1nnc(-c2nc(C)cs2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C24H28FN7O5S2/c1-14-13-38-23(28-14)22-29-30-24(32(22)20-17(36-4)7-6-8-18(20)37-5)31-39(33,34)19(9-10-35-3)15(2)21-26-11-16(25)12-27-21/h6-8,11-13,15,19H,9-10H2,1-5H3,(H,30,31)/t15-,19-/m1/s1
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n/an/an/an/a 6.30n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507152
PNG
(US11046680, Example 23.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)[C@H](O)c2ccc(F)cn2)nnc1-c1ccn(C)n1
Show InChI InChI=1S/C22H24FN7O5S/c1-13(20(31)15-9-8-14(23)12-24-15)36(32,33)28-22-26-25-21(16-10-11-29(2)27-16)30(22)19-17(34-3)6-5-7-18(19)35-4/h5-13,20,31H,1-4H3,(H,26,28)/t13-,20+/m1/s1
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n/an/an/an/a 1.10n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507158
PNG
(US11046680, Example 29.0 | US11046680, Example 30....)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1cnccn1
Show InChI InChI=1S/C21H21FN8O4S/c1-13(9-18-25-10-14(22)11-26-18)35(31,32)29-21-28-27-20(15-12-23-7-8-24-15)30(21)19-16(33-2)5-4-6-17(19)34-3/h4-8,10-13H,9H2,1-3H3,(H,28,29)/t13-/m0/s1
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n/an/an/an/a 47n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507163
PNG
(US11046680, Example 34.0 | US11046680, Example 35....)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1ccn(C)c1
Show InChI InChI=1S/C22H24FN7O4S/c1-14(10-19-24-11-16(23)12-25-19)35(31,32)28-22-27-26-21(15-8-9-29(2)13-15)30(22)20-17(33-3)6-5-7-18(20)34-4/h5-9,11-14H,10H2,1-4H3,(H,27,28)/t14-/m0/s1
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n/an/an/an/a 27n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507171
PNG
(US11046680, Example 42.0 | US11046680, Example 47....)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(F)cn2)nnc1-c1cncnc1
Show InChI InChI=1S/C21H21FN8O4S/c1-13(7-18-25-10-15(22)11-26-18)35(31,32)29-21-28-27-20(14-8-23-12-24-9-14)30(21)19-16(33-2)5-4-6-17(19)34-3/h4-6,8-13H,7H2,1-3H3,(H,28,29)/t13-/m1/s1
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n/an/an/an/a 150n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507170
PNG
(US11046680, Example 41.0 | US11046680, Example 49....)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(F)cn2)nnc1-c1nnc(C)o1
Show InChI InChI=1S/C20H21FN8O5S/c1-11(8-16-22-9-13(21)10-23-16)35(30,31)28-20-27-25-18(19-26-24-12(2)34-19)29(20)17-14(32-3)6-5-7-15(17)33-4/h5-7,9-11H,8H2,1-4H3,(H,27,28)/t11-/m1/s1
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n/an/an/an/a 23n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507182
PNG
(US11046680, Example 53.0 | US11046680, Example 54....)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(F)cn2)nnc1-c1cc(C)n(C)n1
Show InChI InChI=1S/C22H25FN8O4S/c1-13-9-16(28-30(13)3)21-26-27-22(31(21)20-17(34-4)7-6-8-18(20)35-5)29-36(32,33)14(2)10-19-24-11-15(23)12-25-19/h6-9,11-12,14H,10H2,1-5H3,(H,27,29)/t14-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507185
PNG
(US11046680, Example 56.0 | US11046680, Example 58....)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(F)cn2)nnc1-c1ncccn1
Show InChI InChI=1S/C21H21FN8O4S/c1-13(10-17-25-11-14(22)12-26-17)35(31,32)29-21-28-27-20(19-23-8-5-9-24-19)30(21)18-15(33-2)6-4-7-16(18)34-3/h4-9,11-13H,10H2,1-3H3,(H,28,29)/t13-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507200
PNG
(US11046680, Example 71.0 | US11046680, Example 75....)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(F)cn2)nnc1-c1cc[nH]n1
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n/an/an/an/a 55n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507209
PNG
(US11046680, Example 87.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2noc3ccccc23)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C26H27N7O6S/c1-15-13-27-24(28-14-15)23(38-5)16(2)40(34,35)32-26-30-29-25(21-17-9-6-7-10-18(17)39-31-21)33(26)22-19(36-3)11-8-12-20(22)37-4/h6-14,16,23H,1-5H3,(H,30,32)/t16-,23-/m0/s1
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n/an/an/an/a 82n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507210
PNG
(US11046680, Example 88.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)nnc1-c1noc2ccccc12
Show InChI InChI=1S/C24H25N9O5S/c1-13-10-25-20(26-11-13)14(2)15(3)39(34,35)32-24-30-29-21(18-16-8-6-7-9-17(16)38-31-18)33(24)19-22(36-4)27-12-28-23(19)37-5/h6-12,14-15H,1-5H3,(H,30,32)/t14-,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507219
PNG
(US11046680, Example 98.0)
Show SMILES COc1ccc(CNCc2ccc(OC)cc2OC)c(OC)c1
Show InChI InChI=1S/C18H23NO4/c1-20-15-7-5-13(17(9-15)22-3)11-19-12-14-6-8-16(21-2)10-18(14)23-4/h5-10,19H,11-12H2,1-4H3
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n/an/an/an/a 5.30n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507227
PNG
(US11046680, Example 106.0)
Show SMILES CCc1csc(n1)-c1nnc(NS(=O)(=O)[C@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C22H24FN7O4S2/c1-5-15-12-35-21(26-15)20-27-28-22(30(20)19-16(33-3)7-6-8-17(19)34-4)29-36(31,32)13(2)9-18-24-10-14(23)11-25-18/h6-8,10-13H,5,9H2,1-4H3,(H,28,29)/t13-/m1/s1
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n/an/an/an/a 21n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507237
PNG
(US11046680, Example 116.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)C[C@H](O)c2ccc(F)cc2F)nnc1-c1ccn(C)n1
Show InChI InChI=1S/C22H22F2N6O5S/c1-29-10-9-16(27-29)21-25-26-22(30(21)20-18(34-2)5-4-6-19(20)35-3)28-36(32,33)12-17(31)14-8-7-13(23)11-15(14)24/h4-11,17,31H,12H2,1-3H3,(H,26,28)/t17-/m0/s1
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n/an/an/an/a 2.60n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507238
PNG
(US11046680, Example 117.0 | US11046680, Example 11...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccn(C)n2)n1-c1c(OC)cccc1OC)c1ncc(F)cn1
Show InChI InChI=1S/C22H25FN8O5S/c1-13(19(36-5)20-24-11-14(23)12-25-20)37(32,33)29-22-27-26-21(15-9-10-30(2)28-15)31(22)18-16(34-3)7-6-8-17(18)35-4/h6-13,19H,1-5H3,(H,27,29)/t13-,19-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507240
PNG
(US11046680, Example 119.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](C)c2ncc(F)cn2)nnc1-c1nc(C)cs1
Show InChI InChI=1S/C22H24FN7O4S2/c1-12-11-35-21(26-12)20-27-28-22(30(20)18-16(33-4)7-6-8-17(18)34-5)29-36(31,32)14(3)13(2)19-24-9-15(23)10-25-19/h6-11,13-14H,1-5H3,(H,28,29)/t13-,14+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507247
PNG
(US11046680, Example 126.0)
Show SMILES COc1ccc(cc1-n1c(NS(=O)(=O)CCc2ccc(Cl)cc2)nnc1-c1cccs1)N1CCC1=O
Show InChI InChI=1S/C24H22ClN5O4S2/c1-34-20-9-8-18(29-12-10-22(29)31)15-19(20)30-23(21-3-2-13-35-21)26-27-24(30)28-36(32,33)14-11-16-4-6-17(25)7-5-16/h2-9,13,15H,10-12,14H2,1H3,(H,27,28)
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n/an/an/an/a 11n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507249
PNG
(US11046680, Example 128.0 | US11046680, Example 12...)
Show SMILES COc1cccc(C)c1-n1c(NS(=O)(=O)CCc2ccc(Cl)cc2)nnc1-c1cccs1
Show InChI InChI=1S/C22H21ClN4O3S2/c1-15-5-3-6-18(30-2)20(15)27-21(19-7-4-13-31-19)24-25-22(27)26-32(28,29)14-12-16-8-10-17(23)11-9-16/h3-11,13H,12,14H2,1-2H3,(H,25,26)
PDB

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n/an/an/an/a 54n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507254
PNG
(US11046680, Example 133.0)
Show SMILES COc1ccc(Br)cc1-n1c(N)nnc1-c1cccs1
Show InChI InChI=1S/C13H11BrN4OS/c1-19-10-5-4-8(14)7-9(10)18-12(16-17-13(18)15)11-3-2-6-20-11/h2-7H,1H3,(H2,15,17)
PDB

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n/an/an/an/a 363n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507255
PNG
(US11046680, Example 134.0)
Show SMILES CCn1ccc(n1)C(=O)NN\C(NS(=O)(=O)[C@@H](C)[C@H](OC)c1ncc(F)cn1)=N\c1c(OC)cccc1OC
Show InChI InChI=1S/C23H29FN8O6S/c1-6-32-11-10-16(30-32)22(33)28-29-23(27-19-17(36-3)8-7-9-18(19)37-4)31-39(34,35)14(2)20(38-5)21-25-12-15(24)13-26-21/h7-14,20H,6H2,1-5H3,(H,28,33)(H2,27,29,31)/t14-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507260
PNG
(US11046680, Example 139.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)CCc2ccc(Cl)cc2)nnc1-c1cocn1
Show InChI InChI=1S/C21H20ClN5O5S/c1-30-17-4-3-5-18(31-2)19(17)27-20(16-12-32-13-23-16)24-25-21(27)26-33(28,29)11-10-14-6-8-15(22)9-7-14/h3-9,12-13H,10-11H2,1-2H3,(H,25,26)
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507281
PNG
(US11046680, Example 160.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)nnc1-c1nc(cs1)C1CC1
Show InChI InChI=1S/C23H24FN7O4S2/c1-13(9-19-25-10-15(24)11-26-19)37(32,33)30-23-29-28-21(22-27-16(12-36-22)14-7-8-14)31(23)20-17(34-2)5-4-6-18(20)35-3/h4-6,10-14H,7-9H2,1-3H3,(H,29,30)/t13-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507289
PNG
(US11046680, Example 168.0 | US11046680, Example 16...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](OCC=C)c2ncc(F)cn2)nnc1-c1nc(C)cs1
Show InChI InChI=1S/C24H26FN7O5S2/c1-6-10-37-20(21-26-11-16(25)12-27-21)15(3)39(33,34)31-24-30-29-22(23-28-14(2)13-38-23)32(24)19-17(35-4)8-7-9-18(19)36-5/h6-9,11-13,15,20H,1,10H2,2-5H3,(H,30,31)/t15-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507295
PNG
(US11046680, Example 174.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(F)cn2)nnc1-c1ccn(n1)C(F)F
Show InChI InChI=1S/C21H21F3N8O4S/c1-12(9-17-25-10-13(22)11-26-17)37(33,34)30-21-28-27-19(14-7-8-31(29-14)20(23)24)32(21)18-15(35-2)5-4-6-16(18)36-3/h4-8,10-12,20H,9H2,1-3H3,(H,28,30)/t12-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507303
PNG
(US11046680, Example 182.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(F)cn2)nnc1-c1cnccn1
Show InChI InChI=1S/C21H21FN8O4S/c1-13(9-18-25-10-14(22)11-26-18)35(31,32)29-21-28-27-20(15-12-23-7-8-24-15)30(21)19-16(33-2)5-4-6-17(19)34-3/h4-8,10-13H,9H2,1-3H3,(H,28,29)/t13-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507305
PNG
(US11046680, Example 184.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(F)cn2)nnc1-c1ncco1
Show InChI InChI=1S/C20H20FN7O5S/c1-12(9-16-23-10-13(21)11-24-16)34(29,30)27-20-26-25-18(19-22-7-8-33-19)28(20)17-14(31-2)5-4-6-15(17)32-3/h4-8,10-12H,9H2,1-3H3,(H,26,27)/t12-/m1/s1
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n/an/an/an/a 150n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507313
PNG
(US11046680, Example 192.0 | US11046680, Example 19...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(F)cn2)nnc1-c1cnn(C)n1
Show InChI InChI=1S/C20H22FN9O4S/c1-12(8-17-22-9-13(21)10-23-17)35(31,32)28-20-26-25-19(14-11-24-29(2)27-14)30(20)18-15(33-3)6-5-7-16(18)34-4/h5-7,9-12H,8H2,1-4H3,(H,26,28)/t12-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507308
PNG
(US11046680, Example 187.0 | US11046680, Example 19...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(F)cn2)nnc1-c1cocn1
Show InChI InChI=1S/C20H20FN7O5S/c1-12(7-17-22-8-13(21)9-23-17)34(29,30)27-20-26-25-19(14-10-33-11-24-14)28(20)18-15(31-2)5-4-6-16(18)32-3/h4-6,8-12H,7H2,1-3H3,(H,26,27)/t12-/m1/s1
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n/an/an/an/a 140n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507324
PNG
(US11046680, Example 203.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccn(n2)C(F)F)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C23H26F2N8O5S/c1-13-11-26-20(27-12-13)19(38-5)14(2)39(34,35)31-23-29-28-21(15-9-10-32(30-15)22(24)25)33(23)18-16(36-3)7-6-8-17(18)37-4/h6-12,14,19,22H,1-5H3,(H,29,31)/t14-,19-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507328
PNG
(US11046680, Example 207.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccn(n2)C(F)F)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C22H23ClF2N8O5S/c1-12(18(38-4)19-26-10-13(23)11-27-19)39(34,35)31-22-29-28-20(14-8-9-32(30-14)21(24)25)33(22)17-15(36-2)6-5-7-16(17)37-3/h5-12,18,21H,1-4H3,(H,29,31)/t12-,18-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507333
PNG
(US11046680, Example 212.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)nnc1-c1cnn(C)c1
Show InChI InChI=1S/C22H25FN8O4S/c1-13(20-24-10-16(23)11-25-20)14(2)36(32,33)29-22-28-27-21(15-9-26-30(3)12-15)31(22)19-17(34-4)7-6-8-18(19)35-5/h6-14H,1-5H3,(H,28,29)/t13-,14-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507341
PNG
(US11046680, Example 220.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](O)c2ncc(C)cn2)nnc1-c1cc2CCCn2n1
Show InChI InChI=1S/C24H28N8O5S/c1-14-12-25-22(26-13-14)21(33)15(2)38(34,35)30-24-28-27-23(17-11-16-7-6-10-31(16)29-17)32(24)20-18(36-3)8-5-9-19(20)37-4/h5,8-9,11-13,15,21,33H,6-7,10H2,1-4H3,(H,28,30)/t15-,21-/m0/s1
PDB

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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507342
PNG
(US11046680, Example 221.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1-c1cc2CCCn2n1
Show InChI InChI=1S/C24H27ClN8O4S/c1-14(22-26-12-16(25)13-27-22)15(2)38(34,35)31-24-29-28-23(18-11-17-7-6-10-32(17)30-18)33(24)21-19(36-3)8-5-9-20(21)37-4/h5,8-9,11-15H,6-7,10H2,1-4H3,(H,29,31)/t14-,15-/m0/s1
PDB

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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507356
PNG
(US11046680, Example 235.0)
Show SMILES COc1ccccc1NC(=O)c1ccc(F)s1
Show InChI InChI=1S/C12H10FNO2S/c1-16-9-5-3-2-4-8(9)14-12(15)10-6-7-11(13)17-10/h2-7H,1H3,(H,14,15)
PDB

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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507359
PNG
(US11046680, Example 238.0)
Show SMILES COc1ccccc1-n1c(NS(=O)(=O)CCc2ccccc2)nnc1-c1cccs1
Show InChI InChI=1S/C21H20N4O3S2/c1-28-18-11-6-5-10-17(18)25-20(19-12-7-14-29-19)22-23-21(25)24-30(26,27)15-13-16-8-3-2-4-9-16/h2-12,14H,13,15H2,1H3,(H,23,24)
PDB

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n/an/an/an/a 226n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507366
PNG
(US11046680, Example 245.0)
Show SMILES COc1ccc(cc1-n1c(NS(=O)(=O)CCc2ccc(Cl)cc2)nnc1-c1cccs1)C(O)=O
Show InChI InChI=1S/C22H19ClN4O5S2/c1-32-18-9-6-15(21(28)29)13-17(18)27-20(19-3-2-11-33-19)24-25-22(27)26-34(30,31)12-10-14-4-7-16(23)8-5-14/h2-9,11,13H,10,12H2,1H3,(H,25,26)(H,28,29)
PDB

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n/an/an/an/a 210n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507367
PNG
(US11046680, Example 246.0)
Show SMILES Nc1nnc(-c2ccc(F)s2)n1-c1ccccc1OC(F)F
Show InChI InChI=1S/C13H9F3N4OS/c14-10-6-5-9(22-10)11-18-19-13(17)20(11)7-3-1-2-4-8(7)21-12(15)16/h1-6,12H,(H2,17,19)
PDB

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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507375
PNG
(US11046680, Example 254.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H]2C[C@@H](O)CN(C2)c2ncc(F)cn2)nnc1-c1nc(C)cs1
Show InChI InChI=1S/C23H25FN8O5S2/c1-13-12-38-21(27-13)20-28-29-23(32(20)19-17(36-2)5-4-6-18(19)37-3)30-39(34,35)16-7-15(33)10-31(11-16)22-25-8-14(24)9-26-22/h4-6,8-9,12,15-16,33H,7,10-11H2,1-3H3,(H,29,30)/t15-,16+/m1/s1
PDB

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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507380
PNG
(US11046680, Example 259.0)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H]2C[C@@H](O)CN(C2)c2ncc(F)cn2)nnc1-c1ccn(C)n1
Show InChI InChI=1S/C23H26FN9O5S/c1-31-8-7-17(29-31)21-27-28-23(33(21)20-18(37-2)5-4-6-19(20)38-3)30-39(35,36)16-9-15(34)12-32(13-16)22-25-10-14(24)11-26-22/h4-8,10-11,15-16,34H,9,12-13H2,1-3H3,(H,28,30)/t15-,16+/m1/s1
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n/an/an/an/a 82n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507382
PNG
(US11046680, Example 261.0 | US11046680, Example 26...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H]2CCCN(C2)c2ncc(F)cn2)nnc1-c1ccn(C)n1
Show InChI InChI=1S/C23H26FN9O4S/c1-31-11-9-17(29-31)21-27-28-23(33(21)20-18(36-2)7-4-8-19(20)37-3)30-38(34,35)16-6-5-10-32(14-16)22-25-12-15(24)13-26-22/h4,7-9,11-13,16H,5-6,10,14H2,1-3H3,(H,28,30)/t16-/m0/s1
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n/an/an/an/a 190n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507385
PNG
(US11046680, Example 264.0)
Show SMILES COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)[C@H](C)[C@H](O)c2ccc(Br)cc2Br)cc1
Show InChI InChI=1S/C25H27Br2NO5S/c1-17(25(29)23-13-8-20(26)14-24(23)27)34(30,31)28(15-18-4-9-21(32-2)10-5-18)16-19-6-11-22(33-3)12-7-19/h4-14,17,25,29H,15-16H2,1-3H3/t17-,25+/m1/s1
PDB

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n/an/an/an/a 0.800n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507396
PNG
(US11046680, Example 275.0)
Show SMILES CO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cc(C)[nH]n2)n1-c1c(OC)cccc1OC)c1ncc(Cl)s1
PDB

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n/an/an/an/a 3.10n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507409
PNG
(US11046680, Example 288.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccn(C)n2)n1-c1c(OC)ncnc1OC)c1ccc(Cl)cn1
Show InChI InChI=1S/C21H24ClN9O5S/c1-12(17(34-3)14-7-6-13(22)10-23-14)37(32,33)29-21-27-26-18(15-8-9-30(2)28-15)31(21)16-19(35-4)24-11-25-20(16)36-5/h6-12,17H,1-5H3,(H,27,29)/t12-,17-/m0/s1
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n/an/an/an/a 1.30n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507415
PNG
(US11046680, Example 294.0)
Show SMILES COc1ncnc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1-c1ccn(C)n1
Show InChI InChI=1S/C20H23ClN10O4S/c1-11(16-22-8-13(21)9-23-16)12(2)36(32,33)29-20-27-26-17(14-6-7-30(3)28-14)31(20)15-18(34-4)24-10-25-19(15)35-5/h6-12H,1-5H3,(H,27,29)/t11-,12-/m0/s1
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n/an/an/an/a 0.490n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507416
PNG
(US11046680, Example 295.0)
Show SMILES COc1cnc(nc1)[C@@H](C)[C@H](C)S(=O)(=O)Nc1nnc(-c2ccn(C)n2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C23H28N8O5S/c1-14(21-24-12-16(34-4)13-25-21)15(2)37(32,33)29-23-27-26-22(17-10-11-30(3)28-17)31(23)20-18(35-5)8-7-9-19(20)36-6/h7-15H,1-6H3,(H,27,29)/t14-,15-/m0/s1
PDB

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n/an/an/an/a 0.400n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507418
PNG
(US11046680, Example 297.0)
Show SMILES COc1cnc(nc1)[C@H](C)[C@H](C)S(=O)(=O)Nc1nnc(-c2ccn(C)n2)n1-c1c(OC)ncnc1OC
Show InChI InChI=1S/C21H26N10O5S/c1-12(17-22-9-14(34-4)10-23-17)13(2)37(32,33)29-21-27-26-18(15-7-8-30(3)28-15)31(21)16-19(35-5)24-11-25-20(16)36-6/h7-13H,1-6H3,(H,27,29)/t12-,13+/m1/s1
PDB

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n/an/an/an/a 0.140n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507428
PNG
(BDBM507429 | US11046680, Example 307.0)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccn(C)n2)n1-c1c(OC)cccc1OC)c1cnc(OC)cn1
Show InChI InChI=1S/C23H28N8O6S/c1-14(21(37-6)16-12-25-19(36-5)13-24-16)38(32,33)29-23-27-26-22(15-10-11-30(2)28-15)31(23)20-17(34-3)8-7-9-18(20)35-4/h7-14,21H,1-6H3,(H,27,29)/t14-,21-/m0/s1
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n/an/an/an/a 0.580n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens (Human))
BDBM507433
PNG
(US11046680, Example 312.0)
Show SMILES COc1ccc(cc1-n1c(NS(=O)(=O)CCc2ccc(Cl)cc2)nnc1-c1cccs1)S(C)(=O)=O
Show InChI InChI=1S/C22H21ClN4O5S3/c1-32-19-10-9-17(34(2,28)29)14-18(19)27-21(20-4-3-12-33-20)24-25-22(27)26-35(30,31)13-11-15-5-7-16(23)8-6-15/h3-10,12,14H,11,13H2,1-2H3,(H,25,26)
PDB

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n/an/an/an/a 76n/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si...


US Patent US11046680 (2021)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%