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Patent code US11046681

Compile Data Set for Download or QSAR
Found 33 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507637
PNG
(1-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-[[4-hydroxy...)
Show SMILES OC1(Cn2cnc3n(ncc3c2=O)-c2ccc3OCCOc3c2)CCN(CC1)C(=O)[C@@H]1CCNC[C@H]1c1ccccc1
Show InChI InChI=1S/C31H34N6O5/c38-29(23-8-11-32-17-24(23)21-4-2-1-3-5-21)35-12-9-31(40,10-13-35)19-36-20-33-28-25(30(36)39)18-34-37(28)22-6-7-26-27(16-22)42-15-14-41-26/h1-7,16,18,20,23-24,32,40H,8-15,17,19H2/t23-,24+/m1/s1
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n/an/a 19.6n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507626
PNG
(3-[[4-hydroxy-1-[(3R,4R)-3-phenylpiperidine-4-carb...)
Show SMILES COc1ccc(cc1)-n1ccc2c1ncn(CC1(O)CCN(CC1)C(=O)[C@@H]1CCNC[C@H]1c1ccccc1)c2=O
Show InChI InChI=1S/C31H35N5O4/c1-40-24-9-7-23(8-10-24)36-16-12-26-28(36)33-21-35(30(26)38)20-31(39)13-17-34(18-14-31)29(37)25-11-15-32-19-27(25)22-5-3-2-4-6-22/h2-10,12,16,21,25,27,32,39H,11,13-15,17-20H2,1H3/t25-,27+/m1/s1
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n/an/a 28.7n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507620
PNG
(3-[[4-hydroxy-1-[(3R,4R)-3-phenylpiperidine-4-carb...)
Show SMILES OC1(Cn2cnc3n(ccc3c2=O)-c2ccccc2)CCN(CC1)C(=O)[C@@H]1CCNC[C@H]1c1ccccc1
Show InChI InChI=1S/C30H33N5O3/c36-28(24-11-15-31-19-26(24)22-7-3-1-4-8-22)33-17-13-30(38,14-18-33)20-34-21-32-27-25(29(34)37)12-16-35(27)23-9-5-2-6-10-23/h1-10,12,16,21,24,26,31,38H,11,13-15,17-20H2/t24-,26+/m1/s1
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n/an/a 31.6n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507625
PNG
(7-(4-fluorophenyl)-3-[[4-hydroxy-1-[(3R,4R)-3-phen...)
Show SMILES OC1(Cn2cnc3n(ccc3c2=O)-c2ccc(F)cc2)CCN(CC1)C(=O)[C@@H]1CCNC[C@H]1c1ccccc1
Show InChI InChI=1S/C30H32FN5O3/c31-22-6-8-23(9-7-22)36-15-11-25-27(36)33-20-35(29(25)38)19-30(39)12-16-34(17-13-30)28(37)24-10-14-32-18-26(24)21-4-2-1-3-5-21/h1-9,11,15,20,24,26,32,39H,10,12-14,16-19H2/t24-,26+/m1/s1
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n/an/a 37.7n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507635
PNG
(7-(4-fluoro-3-methoxy-phenyl)-3-[[4-hydroxy-1-[(3R...)
Show SMILES COc1cc(ccc1F)-n1ccc2c1ncn(CC1(O)CCN(CC1)C(=O)[C@@H]1CCNC[C@H]1c1ccccc1)c2=O
Show InChI InChI=1S/C31H34FN5O4/c1-41-27-17-22(7-8-26(27)32)37-14-10-24-28(37)34-20-36(30(24)39)19-31(40)11-15-35(16-12-31)29(38)23-9-13-33-18-25(23)21-5-3-2-4-6-21/h2-8,10,14,17,20,23,25,33,40H,9,11-13,15-16,18-19H2,1H3/t23-,25+/m1/s1
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n/an/a 39.3n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507630
PNG
(7-(4-chlorophenyl)-3-[[4-hydroxy-1-[(3R,4R)-3-phen...)
Show SMILES OC1(Cn2cnc3n(ccc3c2=O)-c2ccc(Cl)cc2)CCN(CC1)C(=O)[C@@H]1CCNC[C@H]1c1ccccc1
Show InChI InChI=1S/C30H32ClN5O3/c31-22-6-8-23(9-7-22)36-15-11-25-27(36)33-20-35(29(25)38)19-30(39)12-16-34(17-13-30)28(37)24-10-14-32-18-26(24)21-4-2-1-3-5-21/h1-9,11,15,20,24,26,32,39H,10,12-14,16-19H2/t24-,26+/m1/s1
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n/an/a 41.2n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507627
PNG
(3-[[4-hydroxy-1-[(3R,4R)-3-phenylpiperidine-4-carb...)
Show SMILES COc1cccc(c1)-n1ccc2c1ncn(CC1(O)CCN(CC1)C(=O)[C@@H]1CCNC[C@H]1c1ccccc1)c2=O
Show InChI InChI=1S/C31H35N5O4/c1-40-24-9-5-8-23(18-24)36-15-11-26-28(36)33-21-35(30(26)38)20-31(39)12-16-34(17-13-31)29(37)25-10-14-32-19-27(25)22-6-3-2-4-7-22/h2-9,11,15,18,21,25,27,32,39H,10,12-14,16-17,19-20H2,1H3/t25-,27+/m1/s1
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n/an/a 48.6n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507634
PNG
(7-(4-chlorophenyl)-3-[[4-hydroxy-1-[(3R,4R)-1-meth...)
Show SMILES CN1CC[C@H]([C@@H](C1)c1ccccc1)C(=O)N1CCC(O)(Cn2cnc3n(ccc3c2=O)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C31H34ClN5O3/c1-34-15-11-25(27(19-34)22-5-3-2-4-6-22)29(38)35-17-13-31(40,14-18-35)20-36-21-33-28-26(30(36)39)12-16-37(28)24-9-7-23(32)8-10-24/h2-10,12,16,21,25,27,40H,11,13-15,17-20H2,1H3/t25-,27+/m1/s1
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n/an/a 48.6n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507616
PNG
(US11046681, Example 40 | tert-butyl (3R,4R)-4-[4-h...)
Show SMILES COc1ccc(cc1)-n1ccc2c1ncn(CC1CCN(CC1)C(=O)[C@@H]1CCN(C[C@H]1c1ccccc1)C(=O)OC(C)(C)C)c2=O
Show InChI InChI=1S/C36H43N5O5/c1-36(2,3)46-35(44)39-20-16-29(31(23-39)26-8-6-5-7-9-26)33(42)38-18-14-25(15-19-38)22-40-24-37-32-30(34(40)43)17-21-41(32)27-10-12-28(45-4)13-11-27/h5-13,17,21,24-25,29,31H,14-16,18-20,22-23H2,1-4H3/t29-,31+/m1/s1
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n/an/a 49.9n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507632
PNG
(3-[[4-hydroxy-1-[(3R,4R)-1-methyl-3-phenyl-piperid...)
Show SMILES COc1ccc(cc1)-n1ccc2c1ncn(CC1(O)CCN(CC1)C(=O)[C@@H]1CCN(C)C[C@H]1c1ccccc1)c2=O
Show InChI InChI=1S/C32H37N5O4/c1-34-16-12-26(28(20-34)23-6-4-3-5-7-23)30(38)35-18-14-32(40,15-19-35)21-36-22-33-29-27(31(36)39)13-17-37(29)24-8-10-25(41-2)11-9-24/h3-11,13,17,22,26,28,40H,12,14-16,18-21H2,1-2H3/t26-,28+/m1/s1
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n/an/a 52.4n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507621
PNG
(5-[[4-hydroxy-1-[(3R,4R)-3-phenylpiperidine-4-carb...)
Show SMILES OC1(Cn2cnc3n(ncc3c2=O)-c2ccccc2)CCN(CC1)C(=O)[C@@H]1CCNC[C@H]1c1ccccc1
Show InChI InChI=1S/C29H32N6O3/c36-27(23-11-14-30-17-24(23)21-7-3-1-4-8-21)33-15-12-29(38,13-16-33)19-34-20-31-26-25(28(34)37)18-32-35(26)22-9-5-2-6-10-22/h1-10,18,20,23-24,30,38H,11-17,19H2/t23-,24+/m1/s1
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n/an/a 52.9n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507629
PNG
(7-(3-chlorophenyl)-3-[[4-hydroxy-1-[(3R,4R)-3-phen...)
Show SMILES OC1(Cn2cnc3n(ccc3c2=O)-c2cccc(Cl)c2)CCN(CC1)C(=O)[C@@H]1CCNC[C@H]1c1ccccc1
Show InChI InChI=1S/C30H32ClN5O3/c31-22-7-4-8-23(17-22)36-14-10-25-27(36)33-20-35(29(25)38)19-30(39)11-15-34(16-12-30)28(37)24-9-13-32-18-26(24)21-5-2-1-3-6-21/h1-8,10,14,17,20,24,26,32,39H,9,11-13,15-16,18-19H2/t24-,26+/m1/s1
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n/an/a 56.7n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507617
PNG
(US11046681, Example 44 | tert-butyl (3R,4R)-4-[4-h...)
Show SMILES COc1ccc(cc1)-n1ncc2c1ncn(CC1CCN(CC1)C(=O)[C@@H]1CCN(C[C@H]1c1ccccc1)C(=O)OC(C)(C)C)c2=O
Show InChI InChI=1S/C35H42N6O5/c1-35(2,3)46-34(44)39-19-16-28(30(22-39)25-8-6-5-7-9-25)32(42)38-17-14-24(15-18-38)21-40-23-36-31-29(33(40)43)20-37-41(31)26-10-12-27(45-4)13-11-26/h5-13,20,23-24,28,30H,14-19,21-22H2,1-4H3/t28-,30+/m1/s1
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n/an/a 61.5n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507633
PNG
(7-(3-chlorophenyl)-3-[[4-hydroxy-1-[(3R,4R)-1-meth...)
Show SMILES CN1CC[C@H]([C@@H](C1)c1ccccc1)C(=O)N1CCC(O)(Cn2cnc3n(ccc3c2=O)-c2cccc(Cl)c2)CC1
Show InChI InChI=1S/C31H34ClN5O3/c1-34-14-10-25(27(19-34)22-6-3-2-4-7-22)29(38)35-16-12-31(40,13-17-35)20-36-21-33-28-26(30(36)39)11-15-37(28)24-9-5-8-23(32)18-24/h2-9,11,15,18,21,25,27,40H,10,12-14,16-17,19-20H2,1H3/t25-,27+/m1/s1
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n/an/a 64.8n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507619
PNG
(US11046681, Example 64 | tert-butyl (3R,4R)-4-[4-[...)
Show SMILES CC(C)(C)OC(=O)N1CC[C@H]([C@@H](C1)c1ccccc1)C(=O)N1CCC(O)(Cn2cnc3n(ncc3c2=O)-c2ccc3OC=COc3c2)CC1
Show InChI InChI=1S/C36H40N6O7/c1-35(2,3)49-34(45)40-14-11-26(28(21-40)24-7-5-4-6-8-24)32(43)39-15-12-36(46,13-16-39)22-41-23-37-31-27(33(41)44)20-38-42(31)25-9-10-29-30(19-25)48-18-17-47-29/h4-10,17-20,23,26,28,46H,11-16,21-22H2,1-3H3/t26-,28+/m1/s1
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n/an/a 68.7n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507618
PNG
(US11046681, Example 57 | tert-butyl (3R,4R)-4-[4-[...)
Show SMILES COc1cc(ccc1F)-n1ccc2c1ncn(CC1(O)CCN(CC1)C(=O)[C@@H]1CCN(C[C@H]1c1ccccc1)C(=O)OC(C)(C)C)c2=O
Show InChI InChI=1S/C36H42FN5O6/c1-35(2,3)48-34(45)40-16-12-26(28(21-40)24-8-6-5-7-9-24)32(43)39-18-14-36(46,15-19-39)22-41-23-38-31-27(33(41)44)13-17-42(31)25-10-11-29(37)30(20-25)47-4/h5-11,13,17,20,23,26,28,46H,12,14-16,18-19,21-22H2,1-4H3/t26-,28+/m1/s1
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n/an/a 70.2n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507644
PNG
(3-[[1-[(3R,4R)-1-acetyl-3-phenyl-piperidine-4-carb...)
Show SMILES CC(=O)N1CC[C@H]([C@@H](C1)c1ccccc1)C(=O)N1CCC(O)(Cn2cnc3n(ccc3c2=O)-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C32H34ClN5O4/c1-22(39)36-15-11-26(28(19-36)23-5-3-2-4-6-23)30(40)35-17-13-32(42,14-18-35)20-37-21-34-29-27(31(37)41)12-16-38(29)25-9-7-24(33)8-10-25/h2-10,12,16,21,26,28,42H,11,13-15,17-20H2,1H3/t26-,28+/m1/s1
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n/an/a 74.2n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507628
PNG
(7-(4-fluorophenyl)-3-[[4-hydroxy-1-[(3R,4R)-1-meth...)
Show SMILES CN1CC[C@H]([C@@H](C1)c1ccccc1)C(=O)N1CCC(O)(Cn2cnc3n(ccc3c2=O)-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C31H34FN5O3/c1-34-15-11-25(27(19-34)22-5-3-2-4-6-22)29(38)35-17-13-31(40,14-18-35)20-36-21-33-28-26(30(36)39)12-16-37(28)24-9-7-23(32)8-10-24/h2-10,12,16,21,25,27,40H,11,13-15,17-20H2,1H3/t25-,27+/m1/s1
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n/an/a 74.8n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507645
PNG
(3-[[1-[(3R,4R)-1-(2,2-dimethylpropanoyl)-3-phenyl-...)
Show SMILES CC(C)(C)C(=O)N1CC[C@H]([C@@H](C1)c1ccccc1)C(=O)N1CCC(O)(Cn2cnc3n(ccc3c2=O)-c2ccccc2)CC1
Show InChI InChI=1S/C35H41N5O4/c1-34(2,3)33(43)38-18-14-27(29(22-38)25-10-6-4-7-11-25)31(41)37-20-16-35(44,17-21-37)23-39-24-36-30-28(32(39)42)15-19-40(30)26-12-8-5-9-13-26/h4-13,15,19,24,27,29,44H,14,16-18,20-23H2,1-3H3/t27-,29+/m1/s1
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n/an/a 83n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507642
PNG
(3-[[1-[(3R,4R)-1-acetyl-3-phenyl-piperidine-4-carb...)
Show SMILES COc1cccc(c1)-n1ccc2c1ncn(CC1(O)CCN(CC1)C(=O)[C@@H]1CCN(C[C@H]1c1ccccc1)C(C)=O)c2=O
Show InChI InChI=1S/C33H37N5O5/c1-23(39)36-15-11-27(29(20-36)24-7-4-3-5-8-24)31(40)35-17-13-33(42,14-18-35)21-37-22-34-30-28(32(37)41)12-16-38(30)25-9-6-10-26(19-25)43-2/h3-10,12,16,19,22,27,29,42H,11,13-15,17-18,20-21H2,1-2H3/t27-,29+/m1/s1
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n/an/a 88.4n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507646
PNG
(3-[[1-[(3R,4R)-1-(3,3-dimethylbutanoyl)-3-phenyl-p...)
Show SMILES CC(C)(C)CC(=O)N1CC[C@H]([C@@H](C1)c1ccccc1)C(=O)N1CCC(O)(Cn2cnc3n(ccc3c2=O)-c2ccccc2)CC1
Show InChI InChI=1S/C36H43N5O4/c1-35(2,3)22-31(42)39-18-14-28(30(23-39)26-10-6-4-7-11-26)33(43)38-20-16-36(45,17-21-38)24-40-25-37-32-29(34(40)44)15-19-41(32)27-12-8-5-9-13-27/h4-13,15,19,25,28,30,45H,14,16-18,20-24H2,1-3H3/t28-,30+/m1/s1
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n/an/a 88.5n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507643
PNG
(3-[[1-[(3R,4R)-1-acetyl-3-phenyl-piperidine-4-carb...)
Show SMILES CC(=O)N1CC[C@H]([C@@H](C1)c1ccccc1)C(=O)N1CCC(O)(Cn2cnc3n(ccc3c2=O)-c2cccc(Cl)c2)CC1
Show InChI InChI=1S/C32H34ClN5O4/c1-22(39)36-14-10-26(28(19-36)23-6-3-2-4-7-23)30(40)35-16-12-32(42,13-17-35)20-37-21-34-29-27(31(37)41)11-15-38(29)25-9-5-8-24(33)18-25/h2-9,11,15,18,21,26,28,42H,10,12-14,16-17,19-20H2,1H3/t26-,28+/m1/s1
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n/an/a 89n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507641
PNG
(3-[[1-[(3R,4R)-1-acetyl-3-phenyl-piperidine-4-carb...)
Show SMILES COc1ccc(cc1)-n1ccc2c1ncn(CC1(O)CCN(CC1)C(=O)[C@@H]1CCN(C[C@H]1c1ccccc1)C(C)=O)c2=O
Show InChI InChI=1S/C33H37N5O5/c1-23(39)36-16-12-27(29(20-36)24-6-4-3-5-7-24)31(40)35-18-14-33(42,15-19-35)21-37-22-34-30-28(32(37)41)13-17-38(30)25-8-10-26(43-2)11-9-25/h3-11,13,17,22,27,29,42H,12,14-16,18-21H2,1-2H3/t27-,29+/m1/s1
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n/an/a 96.1n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507638
PNG
(3-[[1-[(3R,4R)-1-acetyl-3-phenyl-piperidine-4-carb...)
Show SMILES CC(=O)N1CC[C@H]([C@@H](C1)c1ccccc1)C(=O)N1CCC(O)(Cn2cnc3n(ccc3c2=O)-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C32H34FN5O4/c1-22(39)36-15-11-26(28(19-36)23-5-3-2-4-6-23)30(40)35-17-13-32(42,14-18-35)20-37-21-34-29-27(31(37)41)12-16-38(29)25-9-7-24(33)8-10-25/h2-10,12,16,21,26,28,42H,11,13-15,17-20H2,1H3/t26-,28+/m1/s1
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n/an/a 102n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507640
PNG
(3-[[4-hydroxy-1-[(3R,4R)-1-(2-methylpropanoyl)-3-p...)
Show SMILES CC(C)C(=O)N1CC[C@H]([C@@H](C1)c1ccccc1)C(=O)N1CCC(O)(Cn2cnc3n(ccc3c2=O)-c2ccccc2)CC1
Show InChI InChI=1S/C34H39N5O4/c1-24(2)31(40)37-17-13-27(29(21-37)25-9-5-3-6-10-25)32(41)36-19-15-34(43,16-20-36)22-38-23-35-30-28(33(38)42)14-18-39(30)26-11-7-4-8-12-26/h3-12,14,18,23-24,27,29,43H,13,15-17,19-22H2,1-2H3/t27-,29+/m1/s1
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n/an/a 103n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507636
PNG
(3-[[4-hydroxy-1-[(3R,4R)-1-isobutyl-3-phenyl-piper...)
Show SMILES CCC(C)N1CC[C@H]([C@@H](C1)c1ccccc1)C(=O)N1CCC(O)(Cn2cnc3n(ccc3c2=O)-c2ccccc2)CC1
Show InChI InChI=1S/C34H41N5O3/c1-3-25(2)37-18-14-28(30(22-37)26-10-6-4-7-11-26)32(40)36-20-16-34(42,17-21-36)23-38-24-35-31-29(33(38)41)15-19-39(31)27-12-8-5-9-13-27/h4-13,15,19,24-25,28,30,42H,3,14,16-18,20-23H2,1-2H3/t25?,28-,30+/m1/s1
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n/an/a 108n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507161
PNG
(US11046681, Example 2 | tert-butyl (3R,4R)-4-[4-hy...)
Show SMILES CC(C)(C)OC(=O)N1CC[C@H]([C@@H](C1)c1ccccc1)C(=O)N1CCC(Cn2cnc3sccc3c2=O)CC1
Show InChI InChI=1S/C29H36N4O4S/c1-29(2,3)37-28(36)32-15-11-22(24(18-32)21-7-5-4-6-8-21)26(34)31-13-9-20(10-14-31)17-33-19-30-25-23(27(33)35)12-16-38-25/h4-8,12,16,19-20,22,24H,9-11,13-15,17-18H2,1-3H3/t22-,24+/m1/s1
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n/an/a 128n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507624
PNG
(3-[[4-hydroxy-1-[(3R,4R)-1-methyl-3-phenyl-piperid...)
Show SMILES CN1CC[C@H]([C@@H](C1)c1ccccc1)C(=O)N1CCC(O)(Cn2cnc3n(ccc3c2=O)-c2ccccc2)CC1
Show InChI InChI=1S/C31H35N5O3/c1-33-16-12-25(27(20-33)23-8-4-2-5-9-23)29(37)34-18-14-31(39,15-19-34)21-35-22-32-28-26(30(35)38)13-17-36(28)24-10-6-3-7-11-24/h2-11,13,17,22,25,27,39H,12,14-16,18-21H2,1H3/t25-,27+/m1/s1
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n/an/a 140n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507450
PNG
(US11046681, Example 15 | tert-butyl (3R,4R)-4-[4-h...)
Show SMILES CC(C)(C)OC(=O)N1CC[C@H]([C@@H](C1)c1ccccc1)C(=O)N1CCC(Cn2cnc3n(ccc3c2=O)-c2ccccn2)CC1
Show InChI InChI=1S/C34H40N6O4/c1-34(2,3)44-33(43)38-19-14-26(28(22-38)25-9-5-4-6-10-25)31(41)37-17-12-24(13-18-37)21-39-23-36-30-27(32(39)42)15-20-40(30)29-11-7-8-16-35-29/h4-11,15-16,20,23-24,26,28H,12-14,17-19,21-22H2,1-3H3/t26-,28+/m1/s1
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n/an/a 274n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507622
PNG
(3-[[4-hydroxy-1-[(3R,4R)-3-phenylpiperidine-4-carb...)
Show SMILES OC1(Cn2cnc3n(ccc3c2=O)-c2ccccn2)CCN(CC1)C(=O)[C@@H]1CCNC[C@H]1c1ccccc1
Show InChI InChI=1S/C29H32N6O3/c36-27(22-9-14-30-18-24(22)21-6-2-1-3-7-21)33-16-11-29(38,12-17-33)19-34-20-32-26-23(28(34)37)10-15-35(26)25-8-4-5-13-31-25/h1-8,10,13,15,20,22,24,30,38H,9,11-12,14,16-19H2/t22-,24+/m1/s1
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n/an/a 394n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507631
PNG
(3-[[1-[(3R,4R)-1-acetyl-3-phenyl-piperidine-4-carb...)
Show SMILES CC(=O)N1CC[C@H]([C@@H](C1)c1ccccc1)C(=O)N1CCC(O)(Cn2cnc3n(ccc3c2=O)-c2ccccc2)CC1
Show InChI InChI=1S/C32H35N5O4/c1-23(38)35-16-12-26(28(20-35)24-8-4-2-5-9-24)30(39)34-18-14-32(41,15-19-34)21-36-22-33-29-27(31(36)40)13-17-37(29)25-10-6-3-7-11-25/h2-11,13,17,22,26,28,41H,12,14-16,18-21H2,1H3/t26-,28+/m1/s1
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n/an/a 406n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507639
PNG
(5-[[1-[(3R,4R)-1,1-dimethyl-3-phenyl-piperidin-1-i...)
Show SMILES COc1ccc(cc1)-n1ncc2c1ncn(CC1(O)CCN(CC1)C(=O)[C@@H]1CC[N+](C)(C)C[C@H]1c1ccccc1)c2=O
Show InChI InChI=1S/C32H39N6O4/c1-38(2)18-13-26(28(20-38)23-7-5-4-6-8-23)30(39)35-16-14-32(41,15-17-35)21-36-22-33-29-27(31(36)40)19-34-37(29)24-9-11-25(42-3)12-10-24/h4-12,19,22,26,28,41H,13-18,20-21H2,1-3H3/q+1/t26-,28+/m1/s1
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n/an/a 860n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 7


(Homo sapiens (Human))
BDBM507623
PNG
(3-[[4-hydroxy-1-[(3R,4R)-3-phenyl-1-(2,2,2-trifluo...)
Show SMILES OC1(Cn2cnc3[nH]ccc3c2=O)CCN(CC1)C(=O)[C@@H]1CCN(CC(F)(F)F)C[C@H]1c1ccccc1
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n/an/a 1.20E+3n/an/an/an/an/an/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
USP7 activity was measured using Rhodamine-110 c-terminal labelled Ubiquitin as a substrate (Viva Biosciences). Incubation with USP7 results in the r...


US Patent US11046681 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%