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Patent code US11046682

Compile Data Set for Download or QSAR
Found 39 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507676
PNG
(US11046682, Compound 51)
Show SMILES O=C(Cc1c(ccc2cncn12)-c1ccccc1)Nc1ccc(cc1)-c1cn[nH]c1
Show InChI InChI=1S/C24H19N5O/c30-24(28-20-8-6-17(7-9-20)19-13-26-27-14-19)12-23-22(18-4-2-1-3-5-18)11-10-21-15-25-16-29(21)23/h1-11,13-16H,12H2,(H,26,27)(H,28,30)
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n/an/a<250n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507677
PNG
(US11046682, Compound 52)
Show SMILES COCCn1cc(cn1)-c1ccc(NC(=O)Cc2c(ccc3cncn23)-c2ccccc2)cc1
Show InChI InChI=1S/C27H25N5O2/c1-34-14-13-31-18-22(16-29-31)20-7-9-23(10-8-20)30-27(33)15-26-25(21-5-3-2-4-6-21)12-11-24-17-28-19-32(24)26/h2-12,16-19H,13-15H2,1H3,(H,30,33)
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Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507672
PNG
(US11046682, Compound 47)
Show SMILES O=C(Cc1c(ccc2cncn12)-c1ccccc1)Nc1ccc(cc1)C(=O)N1CCOCC1
Show InChI InChI=1S/C26H24N4O3/c31-25(28-21-8-6-20(7-9-21)26(32)29-12-14-33-15-13-29)16-24-23(19-4-2-1-3-5-19)11-10-22-17-27-18-30(22)24/h1-11,17-18H,12-16H2,(H,28,31)
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Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507669
PNG
(US11046682, Compound 41)
Show SMILES Clc1cc(CC(=O)Nc2ccc(cc2)C#N)n2cncc2c1
Show InChI InChI=1S/C16H11ClN4O/c17-12-5-14(21-10-19-9-15(21)6-12)7-16(22)20-13-3-1-11(8-18)2-4-13/h1-6,9-10H,7H2,(H,20,22)
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Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507667
PNG
(US11046682, Compound 37)
Show SMILES O=C(Cc1c(ccc2cncn12)-c1ccccc1)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C22H16N4O/c23-13-16-6-8-18(9-7-16)25-22(27)12-21-20(17-4-2-1-3-5-17)11-10-19-14-24-15-26(19)21/h1-11,14-15H,12H2,(H,25,27)
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Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507663
PNG
(US11046682, Compound 32)
Show SMILES O=C(Nc1ccc(nc1)C#N)Nc1c(ccc2cncn12)-c1ccccc1
Show InChI InChI=1S/C20H14N6O/c21-10-15-6-7-16(11-23-15)24-20(27)25-19-18(14-4-2-1-3-5-14)9-8-17-12-22-13-26(17)19/h1-9,11-13H,(H2,24,25,27)
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Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507678
PNG
(US11046682, Compound 53)
Show SMILES O=C(Cc1c(ccc2cncn12)-c1ccccc1)Nc1cc[nH]n1
Show InChI InChI=1S/C18H15N5O/c24-18(21-17-8-9-20-22-17)10-16-15(13-4-2-1-3-5-13)7-6-14-11-19-12-23(14)16/h1-9,11-12H,10H2,(H2,20,21,22,24)
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Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507671
PNG
(US11046682, Compound 45)
Show SMILES ON(C(=O)Cc1c(ccc2cncn12)-c1ccccc1)c1ccc(cc1)C#N
Show InChI InChI=1S/C22H16N4O2/c23-13-16-6-8-18(9-7-16)26(28)22(27)12-21-20(17-4-2-1-3-5-17)11-10-19-14-24-15-25(19)21/h1-11,14-15,28H,12H2
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n/an/a<250n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507657
PNG
(US11046682, Compound 23)
Show SMILES Fc1ccccc1-c1ccc2cncn2c1NC(=O)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C21H14FN5O/c22-19-4-2-1-3-17(19)18-10-9-16-12-24-13-27(16)20(18)26-21(28)25-15-7-5-14(11-23)6-8-15/h1-10,12-13H,(H2,25,26,28)
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Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507675
PNG
(US11046682, Compound 50)
Show SMILES O=C(Cc1c(ccc2cncn12)-c1ccccc1)Nc1ccc(cc1)C(=O)NCCCN1CCOCC1
Show InChI InChI=1S/C29H31N5O3/c35-28(19-27-26(22-5-2-1-3-6-22)12-11-25-20-30-21-34(25)27)32-24-9-7-23(8-10-24)29(36)31-13-4-14-33-15-17-37-18-16-33/h1-3,5-12,20-21H,4,13-19H2,(H,31,36)(H,32,35)
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Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507665
PNG
(US11046682, Compound 34)
Show SMILES COc1cc(NC(=O)Nc2c(ccc3cncn23)-c2ccccc2)ccc1C#N
Show InChI InChI=1S/C22H17N5O2/c1-29-20-11-17(8-7-16(20)12-23)25-22(28)26-21-19(15-5-3-2-4-6-15)10-9-18-13-24-14-27(18)21/h2-11,13-14H,1H3,(H2,25,26,28)
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Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507654
PNG
(US11046682, Compound 20)
Show SMILES Clc1cc(NC(=O)Nc2ccc(cc2)C#N)n2cncc2c1
Show InChI InChI=1S/C15H10ClN5O/c16-11-5-13-8-18-9-21(13)14(6-11)20-15(22)19-12-3-1-10(7-17)2-4-12/h1-6,8-9H,(H2,19,20,22)
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Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507649
PNG
(US11046682, Compound 14)
Show SMILES Fc1ccc2cncn2c1NC(=O)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C15H10FN5O/c16-13-6-5-12-8-18-9-21(12)14(13)20-15(22)19-11-3-1-10(7-17)2-4-11/h1-6,8-9H,(H2,19,20,22)
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Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507652
PNG
(US11046682, Compound 17)
Show SMILES O=C(Nc1ccc(cc1)C#N)Nc1c(ccc2cncn12)-c1ccccc1
Show InChI InChI=1S/C21H15N5O/c22-12-15-6-8-17(9-7-15)24-21(27)25-20-19(16-4-2-1-3-5-16)11-10-18-13-23-14-26(18)20/h1-11,13-14H,(H2,24,25,27)
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n/an/a<250n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507673
PNG
(US11046682, Compound 48)
Show SMILES COC1CCN(CC1)C(=O)c1ccc(NC(=O)Cc2c(ccc3cncn23)-c2ccccc2)cc1
Show InChI InChI=1S/C28H28N4O3/c1-35-24-13-15-31(16-14-24)28(34)21-7-9-22(10-8-21)30-27(33)17-26-25(20-5-3-2-4-6-20)12-11-23-18-29-19-32(23)26/h2-12,18-19,24H,13-17H2,1H3,(H,30,33)
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Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507653
PNG
(US11046682, Compound 19)
Show SMILES Clc1ccc2cncn2c1NC(=O)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C15H10ClN5O/c16-13-6-5-12-8-18-9-21(12)14(13)20-15(22)19-11-3-1-10(7-17)2-4-11/h1-6,8-9H,(H2,19,20,22)
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Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507684
PNG
(US11046682, Compound 62)
Show SMILES CC(C)(O)CNCc1c(ccc2cncn12)-c1ccccc1
Show InChI InChI=1S/C18H21N3O/c1-18(2,22)12-19-11-17-16(14-6-4-3-5-7-14)9-8-15-10-20-13-21(15)17/h3-10,13,19,22H,11-12H2,1-2H3
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Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507656
PNG
(US11046682, Compound 22)
Show SMILES Fc1cccc(c1)-c1ccc2cncn2c1NC(=O)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C21H14FN5O/c22-16-3-1-2-15(10-16)19-9-8-18-12-24-13-27(18)20(19)26-21(28)25-17-6-4-14(11-23)5-7-17/h1-10,12-13H,(H2,25,26,28)
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Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507658
PNG
(US11046682, Compound 24)
Show SMILES O=C(Nc1ccc(cc1)C#N)Nc1c(ccc2cncn12)C1=CCCC1
Show InChI InChI=1S/C20H17N5O/c21-11-14-5-7-16(8-6-14)23-20(26)24-19-18(15-3-1-2-4-15)10-9-17-12-22-13-25(17)19/h3,5-10,12-13H,1-2,4H2,(H2,23,24,26)
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Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507666
PNG
(US11046682, Compound 35)
Show SMILES COc1cc(ccc1NC(=O)Nc1c(ccc2cncn12)-c1ccccc1)C#N
Show InChI InChI=1S/C22H17N5O2/c1-29-20-11-15(12-23)7-10-19(20)25-22(28)26-21-18(16-5-3-2-4-6-16)9-8-17-13-24-14-27(17)21/h2-11,13-14H,1H3,(H2,25,26,28)
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n/an/a<250n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507670
PNG
(US11046682, Compound 42)
Show SMILES N#Cc1ccc(CNCc2c(ccc3cncn23)-c2ccccc2)cc1
Show InChI InChI=1S/C22H18N4/c23-12-17-6-8-18(9-7-17)13-24-15-22-21(19-4-2-1-3-5-19)11-10-20-14-25-16-26(20)22/h1-11,14,16,24H,13,15H2
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n/an/a<250n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507674
PNG
(US11046682, Compound 49)
Show SMILES O=C(Cc1c(ccc2cncn12)-c1ccccc1)Nc1ccc(cc1)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C28H29N5O3/c34-27(18-26-25(21-4-2-1-3-5-21)11-10-24-19-29-20-33(24)26)31-23-8-6-22(7-9-23)28(35)30-12-13-32-14-16-36-17-15-32/h1-11,19-20H,12-18H2,(H,30,35)(H,31,34)
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n/an/a<250n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507648
PNG
(US11046682, Compound 3)
Show SMILES Clc1ccc(NC(=O)Nc2cccc3cncn23)cc1
Show InChI InChI=1S/C14H11ClN4O/c15-10-4-6-11(7-5-10)17-14(20)18-13-3-1-2-12-8-16-9-19(12)13/h1-9H,(H2,17,18,20)
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n/an/a 875n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507668
PNG
(US11046682, Compound 40)
Show SMILES OCc1cc(ccc1NC(=O)Cc1c(ccc2cncn12)-c1ccccc1)C#N
Show InChI InChI=1S/C23H18N4O2/c24-12-16-6-9-21(18(10-16)14-28)26-23(29)11-22-20(17-4-2-1-3-5-17)8-7-19-13-25-15-27(19)22/h1-10,13,15,28H,11,14H2,(H,26,29)
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n/an/a 875n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507683
PNG
(US11046682, Compound 61)
Show SMILES CC(C)CNCc1c(ccc2cncn12)-c1ccccc1
Show InChI InChI=1S/C18H21N3/c1-14(2)10-19-12-18-17(15-6-4-3-5-7-15)9-8-16-11-20-13-21(16)18/h3-9,11,13-14,19H,10,12H2,1-2H3
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n/an/a 875n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507682
PNG
(US11046682, Compound 59)
Show SMILES C(NCc1c(ccc2cncn12)-c1ccccc1)C1CCCCC1
Show InChI InChI=1S/C21H25N3/c1-3-7-17(8-4-1)13-22-15-21-20(18-9-5-2-6-10-18)12-11-19-14-23-16-24(19)21/h2,5-6,9-12,14,16-17,22H,1,3-4,7-8,13,15H2
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n/an/a 875n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507680
PNG
(US11046682, Compound 55)
Show SMILES CN(Cc1ccc(cc1)C#N)Cc1c(ccc2cncn12)-c1ccccc1
Show InChI InChI=1S/C23H20N4/c1-26(15-19-9-7-18(13-24)8-10-19)16-23-22(20-5-3-2-4-6-20)12-11-21-14-25-17-27(21)23/h2-12,14,17H,15-16H2,1H3
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n/an/a 875n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507681
PNG
(US11046682, Compound 58)
Show SMILES C(NCc1c(ccc2cncn12)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H19N3/c1-3-7-17(8-4-1)13-22-15-21-20(18-9-5-2-6-10-18)12-11-19-14-23-16-24(19)21/h1-12,14,16,22H,13,15H2
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n/an/a 875n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507661
PNG
(US11046682, Compound 29)
Show SMILES NC(=O)c1ccc(NC(=O)Nc2c(ccc3cncn23)-c2ccccc2)cc1
Show InChI InChI=1S/C21H17N5O2/c22-19(27)15-6-8-16(9-7-15)24-21(28)25-20-18(14-4-2-1-3-5-14)11-10-17-12-23-13-26(17)20/h1-13H,(H2,22,27)(H2,24,25,28)
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n/an/a 875n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507655
PNG
(US11046682, Compound 21)
Show SMILES Fc1ccc(cc1)-c1ccc2cncn2c1NC(=O)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C21H14FN5O/c22-16-5-3-15(4-6-16)19-10-9-18-12-24-13-27(18)20(19)26-21(28)25-17-7-1-14(11-23)2-8-17/h1-10,12-13H,(H2,25,26,28)
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n/an/a 875n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507659
PNG
(US11046682, Compound 27)
Show SMILES OC(=O)c1ccc(NC(=O)Nc2c(ccc3cncn23)-c2ccccc2)cc1
Show InChI InChI=1S/C21H16N4O3/c26-20(27)15-6-8-16(9-7-15)23-21(28)24-19-18(14-4-2-1-3-5-14)11-10-17-12-22-13-25(17)19/h1-13H,(H,26,27)(H2,23,24,28)
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n/an/a 875n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507664
PNG
(US11046682, Compound 33)
Show SMILES O=C(Nc1ccc(cn1)C#N)Nc1c(ccc2cncn12)-c1ccccc1
Show InChI InChI=1S/C20H14N6O/c21-10-14-6-9-18(23-11-14)24-20(27)25-19-17(15-4-2-1-3-5-15)8-7-16-12-22-13-26(16)19/h1-9,11-13H,(H2,23,24,25,27)
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n/an/a 875n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507662
PNG
(US11046682, Compound 30)
Show SMILES OCCNC(=O)c1ccc(NC(=O)Nc2c(ccc3cncn23)-c2ccccc2)cc1
Show InChI InChI=1S/C23H21N5O3/c29-13-12-25-22(30)17-6-8-18(9-7-17)26-23(31)27-21-20(16-4-2-1-3-5-16)11-10-19-14-24-15-28(19)21/h1-11,14-15,29H,12-13H2,(H,25,30)(H2,26,27,31)
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n/an/a 875n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507660
PNG
(US11046682, Compound 28)
Show SMILES CNC(=O)c1ccc(NC(=O)Nc2c(ccc3cncn23)-c2ccccc2)cc1
Show InChI InChI=1S/C22H19N5O2/c1-23-21(28)16-7-9-17(10-8-16)25-22(29)26-20-19(15-5-3-2-4-6-15)12-11-18-13-24-14-27(18)20/h2-14H,1H3,(H,23,28)(H2,25,26,29)
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n/an/a 875n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507651
PNG
(US11046682, Compound 16)
Show SMILES CCOc1ccc2cncn2c1NC(=O)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C17H15N5O2/c1-2-24-15-8-7-14-10-19-11-22(14)16(15)21-17(23)20-13-5-3-12(9-18)4-6-13/h3-8,10-11H,2H2,1H3,(H2,20,21,23)
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n/an/a 875n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507650
PNG
(US11046682, Compound 15)
Show SMILES COc1ccc2cncn2c1NC(=O)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C16H13N5O2/c1-23-14-7-6-13-9-18-10-21(13)15(14)20-16(22)19-12-4-2-11(8-17)3-5-12/h2-7,9-10H,1H3,(H2,19,20,22)
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n/an/a 875n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507685
PNG
(US11046682, Compound 63B:)
Show SMILES Clc1cc(CC(=O)Nc2ccc(cc2)C#N)c2cn[nH]c2c1
Show InChI InChI=1S/C16H11ClN4O/c17-12-5-11(14-9-19-21-15(14)7-12)6-16(22)20-13-3-1-10(8-18)2-4-13/h1-5,7,9H,6H2,(H,19,21)(H,20,22)
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n/an/a 875n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507679
PNG
(US11046682, Compound 54)
Show SMILES O=C(Cc1c(ccc2cncn12)-c1ccccc1)Nc1cn[nH]c1
Show InChI InChI=1S/C18H15N5O/c24-18(22-14-9-20-21-10-14)8-17-16(13-4-2-1-3-5-13)7-6-15-11-19-12-23(15)17/h1-7,9-12H,8H2,(H,20,21)(H,22,24)
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n/an/a 875n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
Indoleamine 2,3-dioxygenase


(Homo sapiens (Human))
BDBM507647
PNG
(US11046682, Compound 1)
Show SMILES O=C(Nc1ccc(cc1)C#N)Nc1cccc2cncn12
Show InChI InChI=1S/C15H11N5O/c16-8-11-4-6-12(7-5-11)18-15(21)19-14-3-1-2-13-9-17-10-20(13)14/h1-7,9-10H,(H2,18,19,21)
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n/an/a 875n/an/an/an/an/an/a



Beijing Innocare Pharma Tech Co., Ltd

US Patent


Assay Description
The effects of the compounds of the invention on the activity of indoleamine 2,3-dioxygenase (IDO) were evaluated by the Ehrlich method.The experimen...


US Patent US11046682 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%