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Patent code US11046686

Compile Data Set for Download or QSAR
Found 30 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507702
PNG
(N-(5-(6-(3- cyanopyrrolo[1,2- b]pyridazin-7-yl)-4-...)
Show SMILES CC(C)Nc1cc(ncc1-c1nnc(NC(C)=O)s1)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C20H18N8OS/c1-11(2)24-16-7-17(18-5-4-14-6-13(8-21)9-23-28(14)18)22-10-15(16)19-26-27-20(30-19)25-12(3)29/h4-7,9-11H,1-3H3,(H,22,24)(H,25,27,29)
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n/an/a 1n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507715
PNG
(7-(4-(isopropylamino)-5-(5-(tetrahydro-2H-pyran-4-...)
Show SMILES CC(C)Nc1cc(ncc1-c1nnc(s1)C1CCOCC1)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C23H23N7OS/c1-14(2)27-19-10-20(21-4-3-17-9-15(11-24)12-26-30(17)21)25-13-18(19)23-29-28-22(32-23)16-5-7-31-8-6-16/h3-4,9-10,12-14,16H,5-8H2,1-2H3,(H,25,27)
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n/an/a<1n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507710
PNG
((R)-7-(5-(5-((2- fluoro-3-hydroxy-3- methylbutyl)a...)
Show SMILES CC(C)Nc1cc(ncc1-c1nnc(NC[C@@H](F)C(C)(C)O)s1)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C23H25FN8OS/c1-13(2)29-17-8-18(19-6-5-15-7-14(9-25)10-28-32(15)19)26-11-16(17)21-30-31-22(34-21)27-12-20(24)23(3,4)33/h5-8,10-11,13,20,33H,12H2,1-4H3,(H,26,29)(H,27,31)/t20-/m1/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507713
PNG
(7-(4-(isopropylamino)-5-(1,3,4-thiadiazol-2-yl)pyr...)
Show SMILES CC(C)Nc1cc(ncc1-c1nncs1)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C18H15N7S/c1-11(2)23-15-6-16(20-9-14(15)18-24-21-10-26-18)17-4-3-13-5-12(7-19)8-22-25(13)17/h3-6,8-11H,1-2H3,(H,20,23)
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Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507687
PNG
(N-((1R,4r)-4-(5-(6-(3- cyanopyrrolo[1,2- b]pyridaz...)
Show SMILES CC(=O)NC1CC[C@@H](CC1)c1nnc(s1)-c1cnc(cc1N[C@H]1CCC(CC1)c1nnc(o1)C(F)F)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C32H32F2N10O2S/c1-17(45)38-21-8-4-20(5-9-21)31-42-43-32(47-31)24-16-36-26(27-11-10-23-12-18(14-35)15-37-44(23)27)13-25(24)39-22-6-2-19(3-7-22)29-40-41-30(46-29)28(33)34/h10-13,15-16,19-22,28H,2-9H2,1H3,(H,36,39)(H,38,45)/t19?,20-,21?,22-
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Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507690
PNG
(7-(5-(5-(hydroxymethyl)-1,3,4-thiadiazol-2-yl)-4-(...)
Show SMILES CC(C)Nc1cc(ncc1-c1nnc(CO)s1)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C19H17N7OS/c1-11(2)23-15-6-16(21-9-14(15)19-25-24-18(10-27)28-19)17-4-3-13-5-12(7-20)8-22-26(13)17/h3-6,8-9,11,27H,10H2,1-2H3,(H,21,23)
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Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507696
PNG
((R)-N-(1-(5-(6-(3- cyanopyrrolo[1,2- b]pyridazin-7...)
Show SMILES CC(C)Nc1cc(ncc1-c1nnc(s1)C(=O)N1CC[C@H](C1)NC(C)=O)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C25H25N9O2S/c1-14(2)29-20-9-21(22-5-4-18-8-16(10-26)11-28-34(18)22)27-12-19(20)23-31-32-24(37-23)25(36)33-7-6-17(13-33)30-15(3)35/h4-5,8-9,11-12,14,17H,6-7,13H2,1-3H3,(H,27,29)(H,30,35)/t17-/m1/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507697
PNG
((R)-5-(6-(3- cyanopyrrolo[1,2- b]pyridazin-7-yl)-4...)
Show SMILES CC(C)Nc1cc(ncc1-c1nnc(s1)C(=O)NCC(F)C(C)(C)O)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C24H25FN8O2S/c1-13(2)30-17-8-18(19-6-5-15-7-14(9-26)10-29-33(15)19)27-11-16(17)22-31-32-23(36-22)21(34)28-12-20(25)24(3,4)35/h5-8,10-11,13,20,35H,12H2,1-4H3,(H,27,30)(H,28,34)
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Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507700
PNG
((R)-7-(5-(5-(3- hydroxypyrrolidine-1- carbonyl)-1,...)
Show SMILES CC(C)Nc1cc(ncc1-c1nnc(s1)C(=O)N1CC[C@@H](O)C1)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C23H22N8O2S/c1-13(2)27-18-8-19(20-4-3-15-7-14(9-24)10-26-31(15)20)25-11-17(18)21-28-29-22(34-21)23(33)30-6-5-16(32)12-30/h3-4,7-8,10-11,13,16,32H,5-6,12H2,1-2H3,(H,25,27)/t16-/m1/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507704
PNG
(N-((1r,4r)-4-(5-(6-(3- cyanopyrrolo[1,2- b]pyridaz...)
Show SMILES CC(=O)NC1CC[C@@H](CC1)c1nnc(s1)-c1cnc(cc1NC1COC1)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C26H26N8O2S/c1-15(35)30-18-4-2-17(3-5-18)25-32-33-26(37-25)21-12-28-23(9-22(21)31-19-13-36-14-19)24-7-6-20-8-16(10-27)11-29-34(20)24/h6-9,11-12,17-19H,2-5,13-14H2,1H3,(H,28,31)(H,30,35)/t17-,18?
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Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507699
PNG
((S)-7-(5-(5-(3-hydroxypyrrolidine-1-carbonyl)-1,3,...)
Show SMILES CC(C)Nc1cc(ncc1-c1nnc(s1)C(=O)N1CC[C@H](O)C1)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C23H22N8O2S/c1-13(2)27-18-8-19(20-4-3-15-7-14(9-24)10-26-31(15)20)25-11-17(18)21-28-29-22(34-21)23(33)30-6-5-16(32)12-30/h3-4,7-8,10-11,13,16,32H,5-6,12H2,1-2H3,(H,25,27)/t16-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507703
PNG
(N-((1r,4r)-4-(5-(4- ((cyanomethyl)amino)- 6-(3-cya...)
Show SMILES CC(=O)NC1CC[C@@H](CC1)c1nnc(s1)-c1cnc(cc1NCC#N)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C25H23N9OS/c1-15(35)31-18-4-2-17(3-5-18)24-32-33-25(36-24)20-14-29-22(11-21(20)28-9-8-26)23-7-6-19-10-16(12-27)13-30-34(19)23/h6-7,10-11,13-14,17-18H,2-5,9H2,1H3,(H,28,29)(H,31,35)/t17-,18?
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Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507689
PNG
(7-(5-(5-(2-oxa-7- azaspiro[3.5]nonan-7-yl)- 1,3,4-...)
Show SMILES CC(C)Nc1cc(ncc1-c1nnc(s1)N1CCC2(COC2)CC1)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C25H26N8OS/c1-16(2)29-20-10-21(22-4-3-18-9-17(11-26)12-28-33(18)22)27-13-19(20)23-30-31-24(35-23)32-7-5-25(6-8-32)14-34-15-25/h3-4,9-10,12-13,16H,5-8,14-15H2,1-2H3,(H,27,29)
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Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507698
PNG
(5-(6-(3- cyanopyrrolo[1,2- b]pyridazin-7-yl)-4- (i...)
Show SMILES CNC(=O)c1nnc(s1)-c1cnc(cc1NC(C)C)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C20H18N8OS/c1-11(2)25-15-7-16(17-5-4-13-6-12(8-21)9-24-28(13)17)23-10-14(15)19-26-27-20(30-19)18(29)22-3/h4-7,9-11H,1-3H3,(H,22,29)(H,23,25)
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Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507708
PNG
(7-(4-(isopropylamino)-5-(5-methyl-1,3,4-thiadiazol...)
Show SMILES CC(C)Nc1cc(ncc1-c1nnc(C)s1)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C19H17N7S/c1-11(2)23-16-7-17(21-10-15(16)19-25-24-12(3)27-19)18-5-4-14-6-13(8-20)9-22-26(14)18/h4-7,9-11H,1-3H3,(H,21,23)
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Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507706
PNG
(US11046686, Example 23 | methyl (((1R,3r)-3-((5- (...)
Show SMILES COC(=O)NC[C@H]1CC(C1)Nc1cc(ncc1-c1nnc(s1)[C@H]1CCC(CC1)NC(C)=O)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C30H33N9O3S/c1-17(40)35-21-5-3-20(4-6-21)28-37-38-29(43-28)24-16-32-26(27-8-7-23-11-19(13-31)15-34-39(23)27)12-25(24)36-22-9-18(10-22)14-33-30(41)42-2/h7-8,11-12,15-16,18,20-22H,3-6,9-10,14H2,1-2H3,(H,32,36)(H,33,41)(H,35,40)/t18-,20-,21?,22?
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Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507707
PNG
(N-((1r,4r)-4-(5-(6-(3-cyanopyrrolo[1,2-b]pyridazin...)
Show SMILES CC(C)Nc1cc(ncc1-c1nnc(s1)[C@H]1CC[C@@H](CC1)NC(C)=O)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C26H28N8OS/c1-15(2)30-22-11-23(24-9-8-20-10-17(12-27)13-29-34(20)24)28-14-21(22)26-33-32-25(36-26)18-4-6-19(7-5-18)31-16(3)35/h8-11,13-15,18-19H,4-7H2,1-3H3,(H,28,30)(H,31,35)/t18-,19-
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Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507691
PNG
(N-(1-(5-(6-(3-cyanopyrrolo[1,2-b]pyridazin-7-yl)-4...)
Show SMILES CC(C)Nc1cc(ncc1-c1nnc(s1)N1CCC(CC1)NC(C)=O)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C25H27N9OS/c1-15(2)29-21-11-22(23-5-4-19-10-17(12-26)13-28-34(19)23)27-14-20(21)24-31-32-25(36-24)33-8-6-18(7-9-33)30-16(3)35/h4-5,10-11,13-15,18H,6-9H2,1-3H3,(H,27,29)(H,30,35)
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Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507709
PNG
(7-(5-(5-(2-aminoethyl)-1,3,4-thiadiazol-2-yl)-4-(i...)
Show SMILES CC(C)Nc1cc(ncc1-c1nnc(CCN)s1)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C20H20N8S/c1-12(2)25-16-8-17(18-4-3-14-7-13(9-22)10-24-28(14)18)23-11-15(16)20-27-26-19(29-20)5-6-21/h3-4,7-8,10-12H,5-6,21H2,1-2H3,(H,23,25)
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n/an/a 1n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507694
PNG
(5-(6-(3- cyanopyrrolo[1,2- b]pyridazin-7-yl)-4- (i...)
Show SMILES CC(C)Nc1cc(ncc1-c1nnc(s1)C(=O)NCCCN1CCCCC1)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C27H31N9OS/c1-18(2)32-22-14-23(24-8-7-20-13-19(15-28)16-31-36(20)24)30-17-21(22)26-33-34-27(38-26)25(37)29-9-6-12-35-10-4-3-5-11-35/h7-8,13-14,16-18H,3-6,9-12H2,1-2H3,(H,29,37)(H,30,32)
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n/an/a<1n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507688
PNG
(N-((1r,4r)-4-(5-(6-(3- cyanopyrrolo[1,2- b]pyridaz...)
Show SMILES CC(=O)NC1CC[C@@H](CC1)c1nnc(s1)-c1cnc(cc1NC1(C)COC1)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C27H28N8O2S/c1-16(36)31-19-5-3-18(4-6-19)25-33-34-26(38-25)21-13-29-23(10-22(21)32-27(2)14-37-15-27)24-8-7-20-9-17(11-28)12-30-35(20)24/h7-10,12-13,18-19H,3-6,14-15H2,1-2H3,(H,29,32)(H,31,36)/t18-,19?
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n/an/a<1n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507695
PNG
((S)-N-(1-(5-(6-(3- cyanopyrrolo[1,2- b]pyridazin-7...)
Show SMILES CC(C)Nc1cc(ncc1-c1nnc(s1)C(=O)N1CC[C@@H](C1)NC(C)=O)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C25H25N9O2S/c1-14(2)29-20-9-21(22-5-4-18-8-16(10-26)11-28-34(18)22)27-12-19(20)23-31-32-24(37-23)25(36)33-7-6-17(13-33)30-15(3)35/h4-5,8-9,11-12,14,17H,6-7,13H2,1-3H3,(H,27,29)(H,30,35)/t17-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507705
PNG
(N-((1r,4r)-4-(5-(6-(3- cyanopyrrolo[1,2- b]pyridaz...)
Show SMILES CNc1cc(ncc1-c1nnc(s1)[C@H]1CCC(CC1)NC(C)=O)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C24H24N8OS/c1-14(33)29-17-5-3-16(4-6-17)23-30-31-24(34-23)19-13-27-21(10-20(19)26-2)22-8-7-18-9-15(11-25)12-28-32(18)22/h7-10,12-13,16-17H,3-6H2,1-2H3,(H,26,27)(H,29,33)/t16-,17?
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n/an/a<1n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507714
PNG
(7-(5-(5-(3-hydroxy-3-methylbutyl)-1,3,4-thiadiazol...)
Show SMILES CC(C)Nc1cc(ncc1-c1nnc(CCC(C)(C)O)s1)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C23H25N7OS/c1-14(2)27-18-10-19(20-6-5-16-9-15(11-24)12-26-30(16)20)25-13-17(18)22-29-28-21(32-22)7-8-23(3,4)31/h5-6,9-10,12-14,31H,7-8H2,1-4H3,(H,25,27)
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n/an/a<1n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507693
PNG
(7-(5-(5-(4- acetylpiperazine-1- carbonyl)-1,3,4- t...)
Show SMILES CC(C)Nc1cc(ncc1-c1nnc(s1)C(=O)N1CCN(CC1)C(C)=O)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C25H25N9O2S/c1-15(2)29-20-11-21(22-5-4-18-10-17(12-26)13-28-34(18)22)27-14-19(20)23-30-31-24(37-23)25(36)33-8-6-32(7-9-33)16(3)35/h4-5,10-11,13-15H,6-9H2,1-3H3,(H,27,29)
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US Patent
n/an/a<1n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507686
PNG
(US11046686, Example 1 | tert-butyl (2-(5-(6-(3- cy...)
Show SMILES CC(C)Nc1cc(ncc1-c1nnc(CCNC(=O)OC(C)(C)C)s1)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C25H28N8O2S/c1-15(2)30-19-11-20(21-7-6-17-10-16(12-26)13-29-33(17)21)28-14-18(19)23-32-31-22(36-23)8-9-27-24(34)35-25(3,4)5/h6-7,10-11,13-15H,8-9H2,1-5H3,(H,27,34)(H,28,30)
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n/an/a 1.5n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507711
PNG
(7-(5-(5-(1H-pyrrol-1- yl)-1,3,4-thiadiazol- 2-yl)-...)
Show SMILES CC(C)Nc1cc(ncc1-c1nnc(s1)-n1cccc1)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C22H18N8S/c1-14(2)26-18-10-19(20-6-5-16-9-15(11-23)12-25-30(16)20)24-13-17(18)21-27-28-22(31-21)29-7-3-4-8-29/h3-10,12-14H,1-2H3,(H,24,26)
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n/an/a 1.70n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507712
PNG
(7-(4-(isopropylamino)-5-(5-(pyrrolidin-1-yl)-1,3,4...)
Show SMILES CC(C)Nc1cc(ncc1-c1nnc(s1)N1CCCC1)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C22H22N8S/c1-14(2)26-18-10-19(20-6-5-16-9-15(11-23)12-25-30(16)20)24-13-17(18)21-27-28-22(31-21)29-7-3-4-8-29/h5-6,9-10,12-14H,3-4,7-8H2,1-2H3,(H,24,26)
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n/an/a 1.80n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507692
PNG
(7-(5-(5-(4- aminophenyl)-1,3,4- thiadiazol-2-yl)-4...)
Show SMILES CC(C)Nc1cc(ncc1-c1nnc(s1)-c1ccc(N)cc1)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C24H20N8S/c1-14(2)29-20-10-21(22-8-7-18-9-15(11-25)12-28-32(18)22)27-13-19(20)24-31-30-23(33-24)16-3-5-17(26)6-4-16/h3-10,12-14H,26H2,1-2H3,(H,27,29)
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n/an/a 9n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM507701
PNG
(7-(4-(isopropylamino)- 5-(5-(morpholine-4- carbony...)
Show SMILES CC(C)Nc1cc(ncc1-c1nnc(s1)C(=O)N1CCOCC1)-c1ccc2cc(cnn12)C#N
Show InChI InChI=1S/C23H22N8O2S/c1-14(2)27-18-10-19(20-4-3-16-9-15(11-24)12-26-31(16)20)25-13-17(18)21-28-29-22(34-21)23(32)30-5-7-33-8-6-30/h3-4,9-10,12-14H,5-8H2,1-2H3,(H,25,27)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...


US Patent US11046686 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%