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Patent code US11046691

Compile Data Set for Download or QSAR

Found 749 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM508351
PNG
(4-amino-7-(1,1-difluoroethyl)-1- (imidazo[1,2-a]py...)
Show SMILES CC(F)(F)c1ccc2c(N)nc(=O)n(-c3ccn4ccnc4c3)c2c1
Show InChI InChI=1S/C17H13F2N5O/c1-17(18,19)10-2-3-12-13(8-10)24(16(25)22-15(12)20)11-4-6-23-7-5-21-14(23)9-11/h2-9H,1H3,(H2,20,22,25)
PDB

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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM508366
PNG
(6-bromo-1-(2-chlorophenyl)-7-(1,1- difluoroethyl)-...)
Show SMILES CC(F)(F)c1cc2n(-c3ccccc3Cl)c(=O)nc(N[C@H]3C[C@H]3F)c2cc1Br
Show InChI InChI=1S/C19H14BrClF3N3O/c1-19(23,24)10-7-16-9(6-11(10)20)17(25-14-8-13(14)22)26-18(28)27(16)15-5-3-2-4-12(15)21/h2-7,13-14H,8H2,1H3,(H,25,26,28)/t13-,14+/m1/s1
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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM508375
PNG
(1-(2-chlorophenyl)-7-cyclopropyl-4- ((cyclopropylm...)
Show SMILES Clc1ccccc1-n1c2nc(C3CC3)c(cc2c(NCC2CC2)nc1=O)C#N
Show InChI InChI=1S/C21H18ClN5O/c22-16-3-1-2-4-17(16)27-20-15(9-14(10-23)18(25-20)13-7-8-13)19(26-21(27)28)24-11-12-5-6-12/h1-4,9,12-13H,5-8,11H2,(H,24,26,28)
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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM508382
PNG
(1-(2-chloro-6-fluorophenyl)-4- (methylamino)-7- (t...)
Show SMILES CNc1nc(=O)n(-c2c(F)cccc2Cl)c2nc(ccc12)C(F)(F)F
Show InChI InChI=1S/C15H9ClF4N4O/c1-21-12-7-5-6-10(15(18,19)20)22-13(7)24(14(25)23-12)11-8(16)3-2-4-9(11)17/h2-6H,1H3,(H,21,23,25)
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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507717
PNG
(4-(dimethylamino)-7-chloro-1-(4- fluorophenyl)-hyd...)
Show SMILES CN(C)c1nc(=O)n(-c2ccc(F)cc2)c2cc(Cl)ccc12
Show InChI InChI=1S/C16H13ClFN3O/c1-20(2)15-13-8-3-10(17)9-14(13)21(16(22)19-15)12-6-4-11(18)5-7-12/h3-9H,1-2H3
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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507719
PNG
(7-bromo-4-(methylamino)-1-phenyl- quinazolin-2(1H)...)
Show SMILES CNc1nc(=O)n(-c2ccccc2)c2cc(Br)ccc12
Show InChI InChI=1S/C15H12BrN3O/c1-17-14-12-8-7-10(16)9-13(12)19(15(20)18-14)11-5-3-2-4-6-11/h2-9H,1H3,(H,17,18,20)
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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507724
PNG
(7-chloro-4-(3-hydroxyazetidin-1-yl)-1- phenylquina...)
Show SMILES OC1CN(C1)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12
Show InChI InChI=1S/C17H14ClN3O2/c18-11-6-7-14-15(8-11)21(12-4-2-1-3-5-12)17(23)19-16(14)20-9-13(22)10-20/h1-8,13,22H,9-10H2
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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507733
PNG
(4-(dimethylamino)-7-chloro-1-[3- (hydroxymethyl)ph...)
Show SMILES CN(C)c1nc(=O)n(-c2cccc(CO)c2)c2cc(Cl)ccc12
Show InChI InChI=1S/C17H16ClN3O2/c1-20(2)16-14-7-6-12(18)9-15(14)21(17(23)19-16)13-5-3-4-11(8-13)10-22/h3-9,22H,10H2,1-2H3
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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM508403
PNG
(7-cyclopropyl-4-(methylamino)-1- (pyrimidin-5-yl)q...)
Show SMILES CNc1nc(=O)n(-c2cncnc2)c2cc(ccc12)C1CC1
Show InChI InChI=1S/C16H15N5O/c1-17-15-13-5-4-11(10-2-3-10)6-14(13)21(16(22)20-15)12-7-18-9-19-8-12/h4-10H,2-3H2,1H3,(H,17,20,22)
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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM508404
PNG
(4-amino-1-(3-chloropyridin-2-yl)-7- cyclopropylqui...)
Show SMILES Nc1nc(=O)n(-c2ncccc2Cl)c2cc(ccc12)C1CC1
Show InChI InChI=1S/C16H13ClN4O/c17-12-2-1-7-19-15(12)21-13-8-10(9-3-4-9)5-6-11(13)14(18)20-16(21)22/h1-2,5-9H,3-4H2,(H2,18,20,22)
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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM508407
PNG
(4-((trans-2-hydroxycyclobutyl) amino)- 1-phenyl-7-...)
Show SMILES O[C@@H]1CC[C@H]1Nc1nc(=O)n(-c2ccccc2)c2cc(ccc12)C(F)(F)F
Show InChI InChI=1S/C19H16F3N3O2/c20-19(21,22)11-6-7-13-15(10-11)25(12-4-2-1-3-5-12)18(27)24-17(13)23-14-8-9-16(14)26/h1-7,10,14,16,26H,8-9H2,(H,23,24,27)/t14-,16-/m1/s1
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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM508417
PNG
(1-(2-chlorophenyl)-4-(((1S,2S)-2- fluorocyclopropy...)
Show SMILES F[C@@H]1C[C@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C(F)(F)F
Show InChI InChI=1S/C18H12ClF4N3O/c19-11-3-1-2-4-14(11)26-15-7-9(18(21,22)23)5-6-10(15)16(25-17(26)27)24-13-8-12(13)20/h1-7,12-13H,8H2,(H,24,25,27)/t12-,13-/m1/s1
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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM508422
PNG
(1-(2-chlorophenyl)-7-cyclopropyl-4- (((1S,2S)-2-fl...)
Show SMILES F[C@H]1C[C@@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1
Show InChI InChI=1S/C20H17ClFN3O/c21-14-3-1-2-4-17(14)25-18-9-12(11-5-6-11)7-8-13(18)19(24-20(25)26)23-16-10-15(16)22/h1-4,7-9,11,15-16H,5-6,10H2,(H,23,24,26)/t15-,16-/m0/s1
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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM508425
PNG
(1-(2-chloropyridin-3-yl)-7-cyclopropyl- 4-(((lS,2R...)
Show SMILES F[C@@H]1C[C@@H]1Nc1nc(=O)n(-c2cccnc2Cl)c2cc(ccc12)C1CC1
Show InChI InChI=1S/C19H16ClFN4O/c20-17-15(2-1-7-22-17)25-16-8-11(10-3-4-10)5-6-12(16)18(24-19(25)26)23-14-9-13(14)21/h1-2,5-8,10,13-14H,3-4,9H2,(H,23,24,26)/t13-,14+/m1/s1
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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM508431
PNG
(1-(2-chloropyridin-3-yl)-7-cyclopropyl- 4-(methyla...)
Show SMILES CNc1nc(=O)n(-c2cccnc2Cl)c2cc(C3CC3)c(cc12)C#N
Show InChI InChI=1S/C18H14ClN5O/c1-21-17-13-7-11(9-20)12(10-4-5-10)8-15(13)24(18(25)23-17)14-3-2-6-22-16(14)19/h2-3,6-8,10H,4-5H2,1H3,(H,21,23,25)
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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507757
PNG
(N-(3-(7-chloro-4-(dimethylamino)-2- oxoquinazolin-...)
Show SMILES CN(C)c1nc(=O)n(-c2cccc(NS(C)(=O)=O)c2)c2cc(Cl)ccc12
Show InChI InChI=1S/C17H17ClN4O3S/c1-21(2)16-14-8-7-11(18)9-15(14)22(17(23)19-16)13-6-4-5-12(10-13)20-26(3,24)25/h4-10,20H,1-3H3
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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507766
PNG
((S)-7-chloro-4-(3-hydroxypyrrolidin-1- yl)-1-pheny...)
Show SMILES O[C@H]1CCN(C1)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12
Show InChI InChI=1S/C18H16ClN3O2/c19-12-6-7-15-16(10-12)22(13-4-2-1-3-5-13)18(24)20-17(15)21-9-8-14(23)11-21/h1-7,10,14,23H,8-9,11H2/t14-/m0/s1
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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507780
PNG
(4-(dimethylamino)-7-fluoro-1-phenyl- quinazolin-2(...)
Show SMILES CN(C)c1nc(=O)n(-c2ccccc2)c2cc(F)ccc12
Show InChI InChI=1S/C16H14FN3O/c1-19(2)15-13-9-8-11(17)10-14(13)20(16(21)18-15)12-6-4-3-5-7-12/h3-10H,1-2H3
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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM508453
PNG
(7-cyclopropyl-4((2-(dimethylamino)- ethyl)amino)-1...)
Show SMILES CN(C)CCNc1nc(=O)n(-c2cccnc2C)c2cc(ccc12)C1CC1
Show InChI InChI=1S/C21H25N5O/c1-14-18(5-4-10-22-14)26-19-13-16(15-6-7-15)8-9-17(19)20(24-21(26)27)23-11-12-25(2)3/h4-5,8-10,13,15H,6-7,11-12H2,1-3H3,(H,23,24,27)
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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507790
PNG
(4-[((2S,1R)-2- fluorocyclopropyl)amino]-1-(2- chlo...)
Show SMILES F[C@H]1C[C@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1
Show InChI InChI=1S/C20H17ClFN3O/c21-14-3-1-2-4-17(14)25-18-9-12(11-5-6-11)7-8-13(18)19(24-20(25)26)23-16-10-15(16)22/h1-4,7-9,11,15-16H,5-6,10H2,(H,23,24,26)/t15-,16+/m0/s1
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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507793
PNG
(1-benzimidazol-5-yl-4- (dimethylamino)-7- chlorohy...)
Show SMILES CN(C)c1nc(=O)n(-c2ccc3[nH]cnc3c2)c2cc(Cl)ccc12
Show InChI InChI=1S/C17H14ClN5O/c1-22(2)16-12-5-3-10(18)7-15(12)23(17(24)21-16)11-4-6-13-14(8-11)20-9-19-13/h3-9H,1-2H3,(H,19,20)
PDB

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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507804
PNG
(4-(3-aminopyrrolidin-1-yl)-7-chloro-1- phenylquina...)
Show SMILES NC1CCN(C1)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12
Show InChI InChI=1S/C18H17ClN4O/c19-12-6-7-15-16(10-12)23(14-4-2-1-3-5-14)18(24)21-17(15)22-9-8-13(20)11-22/h1-7,10,13H,8-9,11,20H2
PDB

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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507818
PNG
(5-fluoro-4-(methylamino)-1-phenyl-7- (trifluoromet...)
Show SMILES CNc1nc(=O)n(-c2ccccc2)c2cc(cc(F)c12)C(F)(F)F
Show InChI InChI=1S/C16H11F4N3O/c1-21-14-13-11(17)7-9(16(18,19)20)8-12(13)23(15(24)22-14)10-5-3-2-4-6-10/h2-8H,1H3,(H,21,22,24)
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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507847
PNG
(1-(2-chlorophenyl)-4- (cyclobutylamino)-7- (triflu...)
Show SMILES FC(F)(F)c1ccc2c(NC3CCC3)nc(=O)n(-c3ccccc3Cl)c2n1
Show InChI InChI=1S/C18H14ClF3N4O/c19-12-6-1-2-7-13(12)26-16-11(8-9-14(24-16)18(20,21)22)15(25-17(26)27)23-10-4-3-5-10/h1-2,6-10H,3-5H2,(H,23,25,27)
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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507848
PNG
(1-(2-chlorophenyl)-4-(methylamino)-7- (trifluorome...)
Show SMILES CNc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C(F)(F)F
Show InChI InChI=1S/C16H11ClF3N3O/c1-21-14-10-7-6-9(16(18,19)20)8-13(10)23(15(24)22-14)12-5-3-2-4-11(12)17/h2-8H,1H3,(H,21,22,24)
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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507856
PNG
((R)-(1Sa)-(2-chlorophenyl)-4-((1- hydroxypropan-2-...)
Show SMILES C[C@H](CO)Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F
Show InChI InChI=1S/C17H14ClF3N4O2/c1-9(8-26)22-14-10-6-7-13(17(19,20)21)23-15(10)25(16(27)24-14)12-5-3-2-4-11(12)18/h2-7,9,26H,8H2,1H3,(H,22,24,27)/t9-/m1/s1
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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507888
PNG
(7-chloro-1-(2-methoxyphenyl)-4- (methylamino)hydro...)
Show SMILES CNc1nc(=O)n(-c2ccccc2OC)c2cc(Cl)ccc12
Show InChI InChI=1S/C16H14ClN3O2/c1-18-15-11-8-7-10(17)9-13(11)20(16(21)19-15)12-5-3-4-6-14(12)22-2/h3-9H,1-2H3,(H,18,19,21)
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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507912
PNG
(7-chloro-4-[methyl(pyridin-4- ylmethyl)-amino]-1- ...)
Show SMILES CN(Cc1ccncc1)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12
Show InChI InChI=1S/C21H17ClN4O/c1-25(14-15-9-11-23-12-10-15)20-18-8-7-16(22)13-19(18)26(21(27)24-20)17-5-3-2-4-6-17/h2-13H,14H2,1H3
PDB

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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507919
PNG
(4-((2R)-2-methylpyrrolidin-1-yl)-1- phenyl-7-(trif...)
Show SMILES C[C@@H]1CCCN1c1nc(=O)n(-c2ccccc2)c2nc(ccc12)C(F)(F)F
Show InChI InChI=1S/C19H17F3N4O/c1-12-6-5-11-25(12)16-14-9-10-15(19(20,21)22)23-17(14)26(18(27)24-16)13-7-3-2-4-8-13/h2-4,7-10,12H,5-6,11H2,1H3/t12-/m1/s1
PDB

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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507935
PNG
(3-[7-chloro-4-(methylamino)-2-oxo- hydroquinazolin...)
Show SMILES CNc1nc(=O)n(-c2cccc(c2)C(O)=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C16H12ClN3O3/c1-18-14-12-6-5-10(17)8-13(12)20(16(23)19-14)11-4-2-3-9(7-11)15(21)22/h2-8H,1H3,(H,21,22)(H,18,19,23)
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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507943
PNG
(7-cyclopropyl-4-(methylamino)-1-(2- methylphenyl)h...)
Show SMILES CNc1nc(=O)n(-c2ccccc2C)c2cc(ccc12)C1CC1
Show InChI InChI=1S/C19H19N3O/c1-12-5-3-4-6-16(12)22-17-11-14(13-7-8-13)9-10-15(17)18(20-2)21-19(22)23/h3-6,9-11,13H,7-8H2,1-2H3,(H,20,21,23)
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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507947
PNG
(4-((2,2-difluoroethyl)amino)-1-phenyl- 7-(trifluor...)
Show SMILES FC(F)CNc1nc(=O)n(-c2ccccc2)c2nc(ccc12)C(F)(F)F
Show InChI InChI=1S/C16H11F5N4O/c17-12(18)8-22-13-10-6-7-11(16(19,20)21)23-14(10)25(15(26)24-13)9-4-2-1-3-5-9/h1-7,12H,8H2,(H,22,24,26)
PDB

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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507980
PNG
(4-amino-7-chloro-1-(2-chlorophenyl)- hydroquinazol...)
Show SMILES Nc1nc(=O)n(-c2ccccc2Cl)c2cc(Cl)ccc12
Show InChI InChI=1S/C14H9Cl2N3O/c15-8-5-6-9-12(7-8)19(14(20)18-13(9)17)11-4-2-1-3-10(11)16/h1-7H,(H2,17,18,20)
PDB

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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507984
PNG
(1-(2-chlorophenyl)-4-[(methylethyl)- amino]-7-(tri...)
Show SMILES CC(C)Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F
Show InChI InChI=1S/C17H14ClF3N4O/c1-9(2)22-14-10-7-8-13(17(19,20)21)23-15(10)25(16(26)24-14)12-6-4-3-5-11(12)18/h3-9H,1-2H3,(H,22,24,26)
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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507985
PNG
(4-((methyl-d3)amino)-1-phenyl-7- (trifluoromethyl)...)
Show SMILES CNc1nc(=O)n(-c2ccccc2)c2nc(ccc12)C(F)(F)F
Show InChI InChI=1S/C15H11F3N4O/c1-19-12-10-7-8-11(15(16,17)18)20-13(10)22(14(23)21-12)9-5-3-2-4-6-9/h2-8H,1H3,(H,19,21,23)
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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507990
PNG
(1-(3-methyl(2-pyridyl))-4-(methyl- amino)-7-(trifl...)
Show SMILES CNc1nc(=O)n(-c2ncccc2C)c2nc(ccc12)C(F)(F)F
Show InChI InChI=1S/C15H12F3N5O/c1-8-4-3-7-20-12(8)23-13-9(11(19-2)22-14(23)24)5-6-10(21-13)15(16,17)18/h3-7H,1-2H3,(H,19,22,24)
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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM507995
PNG
(7-chloro-1-(imidazol-4-ylmethyl)-4- (methylamino)h...)
Show SMILES CNc1nc(=O)n(Cc2c[nH]cn2)c2cc(Cl)ccc12
Show InChI InChI=1S/C13H12ClN5O/c1-15-12-10-3-2-8(14)4-11(10)19(13(20)18-12)6-9-5-16-7-17-9/h2-5,7H,6H2,1H3,(H,16,17)(H,15,18,20)
PDB

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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM508001
PNG
(1-(2-chlorophenyl)-4-{[2-(methyl- sulfonyl)ethyl]a...)
Show SMILES CS(=O)(=O)CCNc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F
Show InChI InChI=1S/C17H14ClF3N4O3S/c1-29(27,28)9-8-22-14-10-6-7-13(17(19,20)21)23-15(10)25(16(26)24-14)12-5-3-2-4-11(12)18/h2-7H,8-9H2,1H3,(H,22,24,26)
PDB

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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM508002
PNG
(7-cyclopropyl-4-(3-hydroxyazetidin-1- yl)-1-phenyl...)
Show SMILES OC1CN(C1)c1nc(=O)n(-c2ccccc2)c2cc(ccc12)C1CC1
Show InChI InChI=1S/C20H19N3O2/c24-16-11-22(12-16)19-17-9-8-14(13-6-7-13)10-18(17)23(20(25)21-19)15-4-2-1-3-5-15/h1-5,8-10,13,16,24H,6-7,11-12H2
PDB

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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM508004
PNG
(1-(2-chlorophenyl)-4-(((1-(hydroxy- methyl)cyclopr...)
Show SMILES OCC1(CNc2nc(=O)n(-c3ccccc3Cl)c3nc(ccc23)C(F)(F)F)CC1
Show InChI InChI=1S/C19H16ClF3N4O2/c20-12-3-1-2-4-13(12)27-16-11(5-6-14(25-16)19(21,22)23)15(26-17(27)29)24-9-18(10-28)7-8-18/h1-6,28H,7-10H2,(H,24,26,29)
PDB

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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM508019
PNG
(1-(2-chlorophenyl)-4-(((1s,3s)-3- methoxycyclobuty...)
Show SMILES CO[C@@H]1C[C@@H](C1)Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F
Show InChI InChI=1S/C19H16ClF3N4O2/c1-29-11-8-10(9-11)24-16-12-6-7-15(19(21,22)23)25-17(12)27(18(28)26-16)14-5-3-2-4-13(14)20/h2-7,10-11H,8-9H2,1H3,(H,24,26,28)/t10-,11+
PDB

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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM508044
PNG
(3-((1-(2-chlorophenyl)-2-oxo-7- (trifluoro-methyl)...)
Show SMILES FC(F)(F)c1ccc2c(NCCC#N)nc(=O)n(-c3ccccc3Cl)c2n1
Show InChI InChI=1S/C17H11ClF3N5O/c18-11-4-1-2-5-12(11)26-15-10(6-7-13(24-15)17(19,20)21)14(25-16(26)27)23-9-3-8-22/h1-2,4-7H,3,9H2,(H,23,25,27)
PDB

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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM508047
PNG
((R)-7-chloro-4-(3-hydroxypyrrolidin-1- yl)-1-(1H-i...)
Show SMILES O[C@@H]1CCN(C1)c1nc(=O)n(-c2ccc3[nH]ncc3c2)c2cc(Cl)ccc12
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n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM508056
PNG
(4-((2,2-difluoroethyl)amino)-1-(2- methylpyridin-3...)
Show SMILES Cc1ncccc1-n1c2cc(ccc2c(NCC(F)F)nc1=O)C(F)(F)F
Show InChI InChI=1S/C17H13F5N4O/c1-9-12(3-2-6-23-9)26-13-7-10(17(20,21)22)4-5-11(13)15(25-16(26)27)24-8-14(18)19/h2-7,14H,8H2,1H3,(H,24,25,27)
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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM508070
PNG
(3-[4-(methylamino)-2-oxo-7-(trifluoro- methyl)pyri...)
Show SMILES CNc1nc(=O)n(-c2cccc(c2)C#N)c2nc(ccc12)C(F)(F)F
Show InChI InChI=1S/C16H10F3N5O/c1-21-13-11-5-6-12(16(17,18)19)22-14(11)24(15(25)23-13)10-4-2-3-9(7-10)8-20/h2-7H,1H3,(H,21,23,25)
PDB

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IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM508124
PNG
(N,N-dimethyl-3-((2-oxo-1-(o-tolyl)-7- (trifluorome...)
Show SMILES CN(C)S(=O)(=O)CCCNc1nc(=O)n(-c2ccccc2C)c2cc(ccc12)C(F)(F)F
Show InChI InChI=1S/C21H23F3N4O3S/c1-14-7-4-5-8-17(14)28-18-13-15(21(22,23)24)9-10-16(18)19(26-20(28)29)25-11-6-12-32(30,31)27(2)3/h4-5,7-10,13H,6,11-12H2,1-3H3,(H,25,26,29)
PDB

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US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM508127
PNG
(4-((2- (morpholinosulfonyl)ethyl)amino)-1-(o- toly...)
Show SMILES Cc1ccccc1-n1c2cc(ccc2c(NCCS(=O)(=O)N2CCOCC2)nc1=O)C(F)(F)F
Show InChI InChI=1S/C22H23F3N4O4S/c1-15-4-2-3-5-18(15)29-19-14-16(22(23,24)25)6-7-17(19)20(27-21(29)30)26-8-13-34(31,32)28-9-11-33-12-10-28/h2-7,14H,8-13H2,1H3,(H,26,27,30)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM508132
PNG
((R)-4-(2-(methoxymethyl)azetidin-1- yl)-1-(o-tolyl...)
Show SMILES COC[C@H]1CCN1c1nc(=O)n(-c2ccccc2C)c2cc(ccc12)C(F)(F)F
Show InChI InChI=1S/C21H20F3N3O2/c1-13-5-3-4-6-17(13)27-18-11-14(21(22,23)24)7-8-16(18)19(25-20(27)28)26-10-9-15(26)12-29-2/h3-8,11,15H,9-10,12H2,1-2H3/t15-/m1/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM508136
PNG
(3-((2-oxo-1-(o-tolyl)-7-(trifluoro- methyl)-1,2-di...)
Show SMILES Cc1ccccc1-n1c2cc(ccc2c(NCCCS(N)(=O)=O)nc1=O)C(F)(F)F
Show InChI InChI=1S/C19H19F3N4O3S/c1-12-5-2-3-6-15(12)26-16-11-13(19(20,21)22)7-8-14(16)17(25-18(26)27)24-9-4-10-30(23,28)29/h2-3,5-8,11H,4,9-10H2,1H3,(H2,23,28,29)(H,24,25,27)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Human)
BDBM508140
PNG
((S)-4-(2-(hydroxymethyl)morpholino)- 1-(o-tolyl)-7...)
Show SMILES Cc1ccccc1-n1c2cc(ccc2c(nc1=O)N1CCO[C@H](CO)C1)C(F)(F)F
Show InChI InChI=1S/C21H20F3N3O3/c1-13-4-2-3-5-17(13)27-18-10-14(21(22,23)24)6-7-16(18)19(25-20(27)29)26-8-9-30-15(11-26)12-28/h2-7,10,15,28H,8-9,11-12H2,1H3/t15-/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
UniChem
US Patent
n/an/a<200n/an/an/an/an/an/a



IDEAYA BIOSCIENCES, INC.

US Patent


Assay Description
MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...


US Patent US11046691 (2021)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%