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Patent code US11046698

Compile Data Set for Download or QSAR

Found 1366 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424336
PNG
(US10508120, Compound I-791 | US10508120, Compound ...)
Show SMILES CNc1cc(nc2c(cnn12)C(=O)N[C@H]1COC[C@H]1O)-c1cn(CCN2CCOCC2)c2ncccc12
Show InChI InChI=1S/C25H30N8O4/c1-26-22-11-19(29-24-17(12-28-33(22)24)25(35)30-20-14-37-15-21(20)34)18-13-32(23-16(18)3-2-4-27-23)6-5-31-7-9-36-10-8-31/h2-4,11-13,20-21,26,34H,5-10,14-15H2,1H3,(H,30,35)/t20-,21+/m0/s1
PDB

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UniChem
US Patent
n/an/an/a 0.600n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424408
PNG
(US10508120, Compound I-863 | US10508120, Compound ...)
Show SMILES CNc1cc(Nc2cccn(-c3ncccc3F)c2=O)nc2c(cnn12)C(=O)N[C@@H]1CC[C@H]1OC
Show InChI InChI=1S/C23H23FN8O3/c1-25-19-11-18(28-16-6-4-10-31(23(16)34)21-14(24)5-3-9-26-21)30-20-13(12-27-32(19)20)22(33)29-15-7-8-17(15)35-2/h3-6,9-12,15,17,25H,7-8H2,1-2H3,(H,28,30)(H,29,33)/t15-,17-/m1/s1
PDB

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US Patent
n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424412
PNG
(US10508120, Compound I-867 | US10577373, Compound ...)
Show SMILES CNc1cc(Nc2cccn([C@H]3C[C@@H]3F)c2=O)nc2c(cnn12)C(=O)NC1CC1
Show InChI InChI=1S/C19H20FN7O2/c1-21-16-8-15(24-13-3-2-6-26(19(13)29)14-7-12(14)20)25-17-11(9-22-27(16)17)18(28)23-10-4-5-10/h2-3,6,8-10,12,14,21H,4-5,7H2,1H3,(H,23,28)(H,24,25)/t12-,14-/m0/s1
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US Patent
n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424418
PNG
(US10508120, Compound I-873 | US10577373, Compound ...)
Show SMILES CNc1cc(Nc2cccc(n2)N2CC3(CCO3)C2)nc2c(cnn12)C(=O)N[C@@H]1CC[C@@H]1O
Show InChI InChI=1S/C22H26N8O3/c1-23-19-9-17(26-16-3-2-4-18(27-16)29-11-22(12-29)7-8-33-22)28-20-13(10-24-30(19)20)21(32)25-14-5-6-15(14)31/h2-4,9-10,14-15,23,31H,5-8,11-12H2,1H3,(H,25,32)(H,26,27,28)/t14-,15+/m1/s1
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US Patent
n/an/an/a 5.5n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424338
PNG
(US10508120, Compound I-793 | US10508120, Compound ...)
Show SMILES CNc1cc(nc2c(cnn12)C(=O)N[C@@H]1CC[C@@H]1O)-c1cn(CCN2CCCCC2)c2ncccc12
Show InChI InChI=1S/C26H32N8O2/c1-27-23-14-21(30-25-18(15-29-34(23)25)26(36)31-20-7-8-22(20)35)19-16-33(24-17(19)6-5-9-28-24)13-12-32-10-3-2-4-11-32/h5-6,9,14-16,20,22,27,35H,2-4,7-8,10-13H2,1H3,(H,31,36)/t20-,22+/m1/s1
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US Patent
n/an/an/a 5.5n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424420
PNG
(US10508120, Compound I-875 | US10577373, Compound ...)
Show SMILES CNc1cc(nc2c(cnn12)C(=O)N[C@H]1CC[C@H]1O)-c1cn(CCN2CCCCC2)c2ncccc12
Show InChI InChI=1S/C26H32N8O2/c1-27-23-14-21(30-25-18(15-29-34(23)25)26(36)31-20-7-8-22(20)35)19-16-33(24-17(19)6-5-9-28-24)13-12-32-10-3-2-4-11-32/h5-6,9,14-16,20,22,27,35H,2-4,7-8,10-13H2,1H3,(H,31,36)/t20-,22+/m0/s1
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PC sid
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US Patent
n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424431
PNG
(US10508120, Compound I-886 | US10577373, Compound ...)
Show SMILES CNc1cc(nc2c(cnn12)C(=O)N[C@H]1CC[C@@H]1OC)-c1cn(CCN2CCOCC2)c2ncccc12
Show InChI InChI=1S/C26H32N8O3/c1-27-23-14-21(30-25-18(15-29-34(23)25)26(35)31-20-5-6-22(20)36-2)19-16-33(24-17(19)4-3-7-28-24)9-8-32-10-12-37-13-11-32/h3-4,7,14-16,20,22,27H,5-6,8-13H2,1-2H3,(H,31,35)/t20-,22-/m0/s1
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n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424433
PNG
(US10508120, Compound I-888 | US10577373, Compound ...)
Show SMILES CNC(=O)c1occc1Nc1cc(NC)n2ncc(C(=O)N[C@@H]3C[C@@H]3F)c2n1
Show InChI InChI=1S/C17H18FN7O3/c1-19-13-6-12(22-10-3-4-28-14(10)17(27)20-2)24-15-8(7-21-25(13)15)16(26)23-11-5-9(11)18/h3-4,6-7,9,11,19H,5H2,1-2H3,(H,20,27)(H,22,24)(H,23,26)/t9-,11+/m0/s1
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n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424442
PNG
(US10508120, Compound I-897 | US10577373, Compound ...)
Show SMILES CNc1cc(Nc2cccn(C3CCN(CCF)CC3)c2=O)nc2c(cnn12)C(=O)N[C@@H]1CC[C@@H]1O
Show InChI InChI=1S/C24H31FN8O3/c1-26-21-13-20(30-22-16(14-27-33(21)22)23(35)29-17-4-5-19(17)34)28-18-3-2-9-32(24(18)36)15-6-10-31(11-7-15)12-8-25/h2-3,9,13-15,17,19,26,34H,4-8,10-12H2,1H3,(H,28,30)(H,29,35)/t17-,19+/m1/s1
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US Patent
n/an/an/a 0.600n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424458
PNG
(US10508120, Compound I-913 | US10577373, Compound ...)
Show SMILES CNC(=O)c1nscc1Nc1cc(NC)n2ncc(C(=O)NC3CC3)c2n1
Show InChI InChI=1S/C16H18N8O2S/c1-17-12-5-11(21-10-7-27-23-13(10)16(26)18-2)22-14-9(6-19-24(12)14)15(25)20-8-3-4-8/h5-8,17H,3-4H2,1-2H3,(H,18,26)(H,20,25)(H,21,22)
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PC sid
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US Patent
n/an/an/a 0.600n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424410
PNG
(US10508120, Compound I-865 | US10508120, Compound ...)
Show SMILES CNc1cc(Nc2cccn(-c3cccnc3C)c2=O)nc2c(cnn12)C(=O)N[C@H]1CC[C@@H]1OC
Show InChI InChI=1S/C24H26N8O3/c1-14-18(7-4-10-26-14)31-11-5-6-17(24(31)34)28-20-12-21(25-2)32-22(30-20)15(13-27-32)23(33)29-16-8-9-19(16)35-3/h4-7,10-13,16,19,25H,8-9H2,1-3H3,(H,28,30)(H,29,33)/t16-,19-/m0/s1
PDB

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US Patent
n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424471
PNG
(US10508120, Compound I-926 | US10577373, Compound ...)
Show SMILES CNc1cc(Nc2cccn(-c3ccc(F)cn3)c2=O)nc2c(cnn12)C(=O)N[C@H]1CC[C@@H]1OC
Show InChI InChI=1S/C23H23FN8O3/c1-25-20-10-18(28-16-4-3-9-31(23(16)34)19-8-5-13(24)11-26-19)30-21-14(12-27-32(20)21)22(33)29-15-6-7-17(15)35-2/h3-5,8-12,15,17,25H,6-7H2,1-2H3,(H,28,30)(H,29,33)/t15-,17-/m0/s1
PDB

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US Patent
n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424484
PNG
(US10508120, Compound I-1035 | US10508120, Compound...)
Show SMILES CNc1cc(Nc2cccn(-c3ccccc3F)c2=O)nc2c(cnn12)C(=O)N[C@H]1CC[C@H]1O
Show InChI InChI=1S/C23H22FN7O3/c1-25-20-11-19(27-16-6-4-10-30(23(16)34)17-7-3-2-5-14(17)24)29-21-13(12-26-31(20)21)22(33)28-15-8-9-18(15)32/h2-7,10-12,15,18,25,32H,8-9H2,1H3,(H,27,29)(H,28,33)/t15-,18+/m0/s1
PDB

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n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424489
PNG
(US10508120, Compound I-944 | US10577373, Compound ...)
Show SMILES CNc1cc(Nc2cccn(C3CCCCC3)c2=O)nc2c(cnn12)C(=O)NCC(C)CO
Show InChI InChI=1S/C23H31N7O3/c1-15(14-31)12-25-22(32)17-13-26-30-20(24-2)11-19(28-21(17)30)27-18-9-6-10-29(23(18)33)16-7-4-3-5-8-16/h6,9-11,13,15-16,24,31H,3-5,7-8,12,14H2,1-2H3,(H,25,32)(H,27,28)
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US Patent
n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424498
PNG
(US10508120, Compound I-953 | US10577373, Compound ...)
Show SMILES CNc1cc(nc2c(cnn12)C(=O)N[C@@H]1CC[C@H]1OC)-c1cn(CCN2CCN(C)CC2)c2ncccc12
Show InChI InChI=1S/C27H35N9O2/c1-28-24-15-22(31-26-19(16-30-36(24)26)27(37)32-21-6-7-23(21)38-3)20-17-35(25-18(20)5-4-8-29-25)14-13-34-11-9-33(2)10-12-34/h4-5,8,15-17,21,23,28H,6-7,9-14H2,1-3H3,(H,32,37)/t21-,23-/m1/s1
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US Patent
n/an/an/a 0.600n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424501
PNG
(US10508120, Compound I-1103 | US10508120, Compound...)
Show SMILES CNc1cc(Nc2cccn([C@H]3CC[C@H]3O)c2=O)nc2c(cnn12)C(=O)NC1CC1
Show InChI InChI=1S/C20H23N7O3/c1-21-17-9-16(24-13-3-2-8-26(20(13)30)14-6-7-15(14)28)25-18-12(10-22-27(17)18)19(29)23-11-4-5-11/h2-3,8-11,14-15,21,28H,4-7H2,1H3,(H,23,29)(H,24,25)/t14-,15+/m0/s1
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n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424504
PNG
(US10508120, Compound I-959 | US10577373, Compound ...)
Show SMILES CNc1cc(Nc2cccn([C@H]3CC[C@@](C)(CC3)OC)c2=O)nc2c(cnn12)C(=O)N[C@@H]1CC[C@H]1OC
Show InChI InChI=1S/C26H35N7O4/c1-26(37-4)11-9-16(10-12-26)32-13-5-6-19(25(32)35)29-21-14-22(27-2)33-23(31-21)17(15-28-33)24(34)30-18-7-8-20(18)36-3/h5-6,13-16,18,20,27H,7-12H2,1-4H3,(H,29,31)(H,30,34)/t16-,18-,20-,26-/m1/s1
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n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424512
PNG
(US10508120, Compound I-967 | US10577373, Compound ...)
Show SMILES CNc1cc(Nc2cccn(-c3cncc(F)c3)c2=O)nc2c(cnn12)C(=O)NC1CC1
Show InChI InChI=1S/C21H19FN8O2/c1-23-18-8-17(28-19-15(11-25-30(18)19)20(31)26-13-4-5-13)27-16-3-2-6-29(21(16)32)14-7-12(22)9-24-10-14/h2-3,6-11,13,23H,4-5H2,1H3,(H,26,31)(H,27,28)
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n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424439
PNG
(US10508120, Compound I-894 | US10508120, Compound ...)
Show SMILES CNc1cc(Nc2cccn(C(C)C)c2=O)nc2c(cnn12)C(=O)N[C@H]1CC[C@H]1O
Show InChI InChI=1S/C20H25N7O3/c1-11(2)26-8-4-5-14(20(26)30)23-16-9-17(21-3)27-18(25-16)12(10-22-27)19(29)24-13-6-7-15(13)28/h4-5,8-11,13,15,21,28H,6-7H2,1-3H3,(H,23,25)(H,24,29)/t13-,15+/m0/s1
PDB

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n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424537
PNG
(US10508120, Compound I-1080 | US10508120, Compound...)
Show SMILES CNc1cc(nc2c(cnn12)C(=O)N[C@H]1CC[C@H]1O)-c1cn(C2CC2)c2ncccc12
Show InChI InChI=1S/C22H23N7O2/c1-23-19-9-17(15-11-28(12-4-5-12)20-13(15)3-2-8-24-20)26-21-14(10-25-29(19)21)22(31)27-16-6-7-18(16)30/h2-3,8-12,16,18,23,30H,4-7H2,1H3,(H,27,31)/t16-,18+/m0/s1
PDB

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n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424554
PNG
(US10508120, Compound I-1009 | US10577373, Compound...)
Show SMILES CNc1cc(Nc2cccn(C3CCCN(CCC#N)C3)c2=O)nc2c(cnn12)C(=O)NC1CC1
Show InChI InChI=1S/C24H29N9O2/c1-26-21-13-20(30-22-18(14-27-33(21)22)23(34)28-16-7-8-16)29-19-6-3-12-32(24(19)35)17-5-2-10-31(15-17)11-4-9-25/h3,6,12-14,16-17,26H,2,4-5,7-8,10-11,15H2,1H3,(H,28,34)(H,29,30)
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n/an/an/a 0.600n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM423556
PNG
(US10508120, Compound I-11 | US10577373, Compound I...)
Show SMILES CNc1cc(Nc2cnn(C)c2)nc2c(cnn12)C(N)=O
Show InChI InChI=1S/C12H14N8O/c1-14-10-3-9(17-7-4-15-19(2)6-7)18-12-8(11(13)21)5-16-20(10)12/h3-6,14H,1-2H3,(H2,13,21)(H,17,18)
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n/an/an/a 5.5n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM423558
PNG
(US10508120, Compound I-13 | US10577373, Compound I...)
Show SMILES CNc1cc(Nc2cc(C)nc(C)c2)nc2c(cnn12)C(N)=O
Show InChI InChI=1S/C15H17N7O/c1-8-4-10(5-9(2)19-8)20-12-6-13(17-3)22-15(21-12)11(7-18-22)14(16)23/h4-7,17H,1-3H3,(H2,16,23)(H,19,20,21)
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n/an/an/a 5.5n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM423565
PNG
(US10508120, Compound I-20 | US10577373, Compound I...)
Show SMILES CNc1cc(Nc2cccn(-c3ccn(n3)C3CC3)c2=O)nc2c(cnn12)C(N)=O
Show InChI InChI=1S/C19H19N9O2/c1-21-16-9-14(24-18-12(17(20)29)10-22-28(16)18)23-13-3-2-7-26(19(13)30)15-6-8-27(25-15)11-4-5-11/h2-3,6-11,21H,4-5H2,1H3,(H2,20,29)(H,23,24)
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n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM423566
PNG
(US10508120, Compound I-21 | US10577373, Compound I...)
Show SMILES Cc1cc(C)cc(Nc2cc(N)n3ncc(C(N)=O)c3n2)c1
Show InChI InChI=1S/C15H16N6O/c1-8-3-9(2)5-10(4-8)19-13-6-12(16)21-15(20-13)11(7-18-21)14(17)22/h3-7H,16H2,1-2H3,(H2,17,22)(H,19,20)
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n/an/an/a 0.600n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM423588
PNG
(US10508120, Compound I-43 | US10577373, Compound I...)
Show SMILES CNc1cc(Nc2cccn(-c3ccon3)c2=O)nc2c(cnn12)C(N)=O
Show InChI InChI=1S/C16H14N8O3/c1-18-13-7-11(21-15-9(14(17)25)8-19-24(13)15)20-10-3-2-5-23(16(10)26)12-4-6-27-22-12/h2-8,18H,1H3,(H2,17,25)(H,20,21)
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n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM423594
PNG
(US10508120, Compound I-49 | US10577373, Compound I...)
Show SMILES CCn1cc(Cl)cc(Nc2cc(N)n3ncc(C(N)=O)c3n2)c1=O
Show InChI InChI=1S/C14H14ClN7O2/c1-2-21-6-7(15)3-9(14(21)24)19-11-4-10(16)22-13(20-11)8(5-18-22)12(17)23/h3-6H,2,16H2,1H3,(H2,17,23)(H,19,20)
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n/an/an/a 0.600n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424588
PNG
(US10508120, Compound I-1043 | US10577373, Compound...)
Show SMILES CNc1cc(Nc2cccn([C@@H]3CCC[C@H](C3)OC)c2=O)nc2c(cnn12)C(=O)N[C@@H]1C[C@@H]1F
Show InChI InChI=1S/C23H28FN7O3/c1-25-20-11-19(29-21-15(12-26-31(20)21)22(32)28-18-10-16(18)24)27-17-7-4-8-30(23(17)33)13-5-3-6-14(9-13)34-2/h4,7-8,11-14,16,18,25H,3,5-6,9-10H2,1-2H3,(H,27,29)(H,28,32)/t13-,14-,16+,18-/m1/s1
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n/an/an/a 0.600n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM423621
PNG
(US10508120, Compound I-76 | US10577373, Compound I...)
Show SMILES NC(=O)c1cnn2c(N)cc(Nc3cccn([C@@H]4CC[C@@H](CC4)N4CCOCC4)c3=O)nc12
Show InChI InChI=1S/C22H28N8O3/c23-18-12-19(27-21-16(20(24)31)13-25-30(18)21)26-17-2-1-7-29(22(17)32)15-5-3-14(4-6-15)28-8-10-33-11-9-28/h1-2,7,12-15H,3-6,8-11,23H2,(H2,24,31)(H,26,27)/t14-,15+
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n/an/an/a 5.5n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM423623
PNG
(US10508120, Compound I-78 | US10577373, Compound I...)
Show SMILES CNc1cc(Nc2cc(Cl)cnc2OC(C)C)nc2c(cnn12)C(N)=O
Show InChI InChI=1S/C16H18ClN7O2/c1-8(2)26-16-11(4-9(17)6-20-16)22-12-5-13(19-3)24-15(23-12)10(7-21-24)14(18)25/h4-8,19H,1-3H3,(H2,18,25)(H,22,23)
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n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM423640
PNG
(US10508120, Compound I-95 | US10577373, Compound I...)
Show SMILES CNc1cc(Nc2cccn(-c3cnc(cn3)C(C)(C)O)c2=O)nc2c(cnn12)C(=O)NC1CCC1
Show InChI InChI=1S/C24H27N9O3/c1-24(2,36)17-12-27-20(13-26-17)32-9-5-8-16(23(32)35)30-18-10-19(25-3)33-21(31-18)15(11-28-33)22(34)29-14-6-4-7-14/h5,8-14,25,36H,4,6-7H2,1-3H3,(H,29,34)(H,30,31)
PDB

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n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM423647
PNG
(US10508120, Compound I-102 | US10577373, Compound ...)
Show SMILES NC(=O)c1cnn2c(N)cc(Nc3cccnc3OC(F)(F)F)nc12
Show InChI InChI=1S/C13H10F3N7O2/c14-13(15,16)25-12-7(2-1-3-19-12)21-9-4-8(17)23-11(22-9)6(5-20-23)10(18)24/h1-5H,17H2,(H2,18,24)(H,21,22)
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n/an/an/a 0.600n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM423666
PNG
(US10508120, Compound I-121 | US10577373, Compound ...)
Show SMILES CNc1cc(Nc2cccn(-c3ccc(cn3)C(=O)N3CCCC3)c2=O)nc2c(cnn12)C(=O)NC1CCC1
Show InChI InChI=1S/C27H29N9O3/c1-28-23-14-21(33-24-19(16-30-36(23)24)25(37)31-18-6-4-7-18)32-20-8-5-13-35(27(20)39)22-10-9-17(15-29-22)26(38)34-11-2-3-12-34/h5,8-10,13-16,18,28H,2-4,6-7,11-12H2,1H3,(H,31,37)(H,32,33)
PDB

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n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424637
PNG
(US10508120, Compound I-1092 | US10508120, Compound...)
Show SMILES CNc1cc(Nc2cccn([C@H]3C[C@@H]3F)c2=O)nc2c(cnn12)C(=O)N[C@@H]1CC[C@H]1O
Show InChI InChI=1S/C20H22FN7O3/c1-22-17-8-16(24-13-3-2-6-27(20(13)31)14-7-11(14)21)26-18-10(9-23-28(17)18)19(30)25-12-4-5-15(12)29/h2-3,6,8-9,11-12,14-15,22,29H,4-5,7H2,1H3,(H,24,26)(H,25,30)/t11-,12+,14-,15+/m0/s1
PDB

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n/an/an/a 0.600n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424658
PNG
(US10508120, Compound I-1113 | US10577373, Compound...)
Show SMILES CNc1cc(nc2c(cnn12)C(=O)N[C@H]1CC[C@H]1O)-c1cn(C2CCOCC2)c2ncccc12
Show InChI InChI=1S/C24H27N7O3/c1-25-21-11-19(28-23-16(12-27-31(21)23)24(33)29-18-4-5-20(18)32)17-13-30(14-6-9-34-10-7-14)22-15(17)3-2-8-26-22/h2-3,8,11-14,18,20,25,32H,4-7,9-10H2,1H3,(H,29,33)/t18-,20+/m0/s1
PDB

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n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424665
PNG
(US10508120, Compound I-1120 | US10577373, Compound...)
Show SMILES CNc1cc(Nc2cccn(C3CCCCC3)c2=O)nc2c(cnn12)C(=O)NC[C@H](C)CO
Show InChI InChI=1S/C23H31N7O3/c1-15(14-31)12-25-22(32)17-13-26-30-20(24-2)11-19(28-21(17)30)27-18-9-6-10-29(23(18)33)16-7-4-3-5-8-16/h6,9-11,13,15-16,24,31H,3-5,7-8,12,14H2,1-2H3,(H,25,32)(H,27,28)/t15-/m0/s1
PDB

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n/an/an/a 0.600n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424683
PNG
(US10508120, Compound I-1187 | US10508120, Compound...)
Show SMILES CNc1cc(Nc2cccn([C@H]3C[C@@H]3OC)c2=O)nc2c(cnn12)C(=O)N[C@H]1CC[C@@H]1OC
Show InChI InChI=1S/C22H27N7O4/c1-23-19-10-18(25-14-5-4-8-28(22(14)31)15-9-17(15)33-3)27-20-12(11-24-29(19)20)21(30)26-13-6-7-16(13)32-2/h4-5,8,10-11,13,15-17,23H,6-7,9H2,1-3H3,(H,25,27)(H,26,30)/t13-,15-,16-,17-/m0/s1
PDB

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n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424684
PNG
(US10508120, Compound I-1188 | US10508120, Compound...)
Show SMILES CNc1cc(Nc2cccn(-c3ccc(C)nc3)c2=O)nc2c(cnn12)C(=O)N[C@H]1CCC[C@@H](C1)OC
Show InChI InChI=1S/C26H30N8O3/c1-16-9-10-18(14-28-16)33-11-5-8-21(26(33)36)31-22-13-23(27-2)34-24(32-22)20(15-29-34)25(35)30-17-6-4-7-19(12-17)37-3/h5,8-11,13-15,17,19,27H,4,6-7,12H2,1-3H3,(H,30,35)(H,31,32)/t17-,19-/m0/s1
PDB

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n/an/an/a 5.5n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424689
PNG
(BDBM424792 | US10508120, Compound I-1193 | US10577...)
Show SMILES CNc1cc(Nc2cccn([C@H]3CCC[C@@H](O)C3)c2=O)nc2c(cnn12)C(=O)N[C@H]1CC[C@@H]1OC
Show InChI InChI=1S/C24H31N7O4/c1-25-21-12-20(27-18-7-4-10-30(24(18)34)14-5-3-6-15(32)11-14)29-22-16(13-26-31(21)22)23(33)28-17-8-9-19(17)35-2/h4,7,10,12-15,17,19,25,32H,3,5-6,8-9,11H2,1-2H3,(H,27,29)(H,28,33)/t14-,15+,17-,19-/m0/s1
PDB

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n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424694
PNG
(US10508120, Compound I-1198 | US10577373, Compound...)
Show SMILES CNc1cc(Nc2cccn(C3CC(F)(F)C3)c2=O)nc2c(cnn12)C(=O)N[C@@H]1CC[C@H]1O
Show InChI InChI=1S/C21H23F2N7O3/c1-24-17-7-16(26-14-3-2-6-29(20(14)33)11-8-21(22,23)9-11)28-18-12(10-25-30(17)18)19(32)27-13-4-5-15(13)31/h2-3,6-7,10-11,13,15,24,31H,4-5,8-9H2,1H3,(H,26,28)(H,27,32)/t13-,15-/m1/s1
PDB

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n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM423690
PNG
(US10508120, Compound I-145 | US10577373, Compound ...)
Show SMILES CNc1cc(Nc2cccnc2OC(C)C)nc2c(cnn12)C(=O)NC1CCC1
Show InChI InChI=1S/C20H25N7O2/c1-12(2)29-20-15(8-5-9-22-20)25-16-10-17(21-3)27-18(26-16)14(11-23-27)19(28)24-13-6-4-7-13/h5,8-13,21H,4,6-7H2,1-3H3,(H,24,28)(H,25,26)
PDB

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n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM423696
PNG
(US10508120, Compound I-151 | US10577373, Compound ...)
Show SMILES CNc1cc(Nc2cccnc2OC(F)F)nc2c(cnn12)C(=O)NC1CCC1
Show InChI InChI=1S/C18H19F2N7O2/c1-21-14-8-13(25-12-6-3-7-22-17(12)29-18(19)20)26-15-11(9-23-27(14)15)16(28)24-10-4-2-5-10/h3,6-10,18,21H,2,4-5H2,1H3,(H,24,28)(H,25,26)
PDB

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n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM423702
PNG
(US10508120, Compound I-157 | US10577373, Compound ...)
Show SMILES CNc1cc(Nc2cccn(-c3nccs3)c2=O)nc2c(cnn12)C(=O)NC1CC1
Show InChI InChI=1S/C19H18N8O2S/c1-20-15-9-14(24-13-3-2-7-26(18(13)29)19-21-6-8-30-19)25-16-12(10-22-27(15)16)17(28)23-11-4-5-11/h2-3,6-11,20H,4-5H2,1H3,(H,23,28)(H,24,25)
PDB

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PC sid
UniChem
US Patent
n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM423713
PNG
(US10508120, Compound I-168 | US10577373, Compound ...)
Show SMILES CNc1cc(Nc2cccnc2OC2CCC2)nc2c(cnn12)C(=O)NC1CCC1
Show InChI InChI=1S/C21H25N7O2/c1-22-18-11-17(26-16-9-4-10-23-21(16)30-14-7-3-8-14)27-19-15(12-24-28(18)19)20(29)25-13-5-2-6-13/h4,9-14,22H,2-3,5-8H2,1H3,(H,25,29)(H,26,27)
PDB

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UniChem
US Patent
n/an/an/a 0.600n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM423732
PNG
(US10508120, Compound I-187 | US10577373, Compound ...)
Show SMILES CNc1cc(Nc2cccnc2O[C@H]2C[C@@H](C2)OC)nc2c(cnn12)C(=O)NC1CCC1
Show InChI InChI=1S/C22H27N7O3/c1-23-19-11-18(27-17-7-4-8-24-22(17)32-15-9-14(10-15)31-2)28-20-16(12-25-29(19)20)21(30)26-13-5-3-6-13/h4,7-8,11-15,23H,3,5-6,9-10H2,1-2H3,(H,26,30)(H,27,28)/t14-,15-
PDB

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PC sid
UniChem
US Patent
n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM423734
PNG
(US10508120, Compound I-189 | US10577373, Compound ...)
Show SMILES CNc1cc(Nc2cccnc2O[C@H]2C[C@@H](C2)OC)nc2c(cnn12)C(=O)N[C@H]1C[C@H]1F
Show InChI InChI=1S/C21H24FN7O3/c1-23-18-9-17(26-15-4-3-5-24-21(15)32-12-6-11(7-12)31-2)28-19-13(10-25-29(18)19)20(30)27-16-8-14(16)22/h3-5,9-12,14,16,23H,6-8H2,1-2H3,(H,26,28)(H,27,30)/t11-,12-,14-,16+/m1/s1
PDB

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US Patent
n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424705
PNG
(US10508120, Compound I-1209 | US10577373, Compound...)
Show SMILES CNc1cc(Nc2cccn(C3CC(F)(F)C3)c2=O)nc2c(cnn12)C(=O)N[C@@H]1CCC[C@@H](O)C1
Show InChI InChI=1S/C23H27F2N7O3/c1-26-19-9-18(29-17-6-3-7-31(22(17)35)14-10-23(24,25)11-14)30-20-16(12-27-32(19)20)21(34)28-13-4-2-5-15(33)8-13/h3,6-7,9,12-15,26,33H,2,4-5,8,10-11H2,1H3,(H,28,34)(H,29,30)/t13-,15-/m1/s1
PDB

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US Patent
n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424732
PNG
(US10508120, Compound I-1236 | US10577373, Compound...)
Show SMILES CNc1cc(Nc2cccn([C@@H]3CCCOC3)c2=O)nc2c(cnn12)C(=O)N[C@@H]1CCC[C@](C)(C1)OC
Show InChI InChI=1S/C26H35N7O4/c1-26(36-3)10-4-7-17(14-26)29-24(34)19-15-28-33-22(27-2)13-21(31-23(19)33)30-20-9-5-11-32(25(20)35)18-8-6-12-37-16-18/h5,9,11,13,15,17-18,27H,4,6-8,10,12,14,16H2,1-3H3,(H,29,34)(H,30,31)/t17-,18-,26-/m1/s1
PDB

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US Patent
n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424741
PNG
(US10508120, Compound I-1245 | US10508120, Compound...)
Show SMILES CNc1cc(Nc2cccn([C@H]3CCC[C@H](C3)C#N)c2=O)nc2c(cnn12)C(=O)NC1CC1
Show InChI InChI=1S/C23H26N8O2/c1-25-20-11-19(29-21-17(13-26-31(20)21)22(32)27-15-7-8-15)28-18-6-3-9-30(23(18)33)16-5-2-4-14(10-16)12-24/h3,6,9,11,13-16,25H,2,4-5,7-8,10H2,1H3,(H,27,32)(H,28,29)/t14-,16+/m1/s1
PDB

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PC sid
UniChem
US Patent
n/an/an/a 0.600n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
TYK2 JH2 Domain (aa 556-888)


(Homo sapiens (Human))
BDBM424743
PNG
(US10508120, Compound I-1247 | US10577373, Compound...)
Show SMILES CNc1cc(nc2c(cnn12)C(=O)N[C@@H]1CC[C@@H]1O)-c1cn([C@@H]2CCC[C@H]2OC)c2ncccc12
Show InChI InChI=1S/C25H29N7O3/c1-26-22-11-18(29-24-15(12-28-32(22)24)25(34)30-17-8-9-20(17)33)16-13-31(19-6-3-7-21(19)35-2)23-14(16)5-4-10-27-23/h4-5,10-13,17,19-21,26,33H,3,6-9H2,1-2H3,(H,30,34)/t17-,19-,20+,21-/m1/s1
PDB

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UniChem
US Patent
n/an/an/a<0.200n/an/an/an/an/a



Nimbus Lakshmi, Inc.

US Patent


Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...


US Patent US11046698 (2021)

More data for this
Ligand-Target Pair
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