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Patent code US11046710

Compile Data Set for Download or QSAR
Found 48 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508497
PNG
(5-chloro-N-[(9S,9aS)-9-hydroxy-5-oxo-8,9,9a,10-tet...)
Show SMILES O[C@H]1CCN2[C@H]1COc1ncc(NS(=O)(=O)c3cc(Cl)ccc3OC(F)(F)F)cc1C2=O
Show InChI InChI=1S/C18H15ClF3N3O6S/c19-9-1-2-14(31-18(20,21)22)15(5-9)32(28,29)24-10-6-11-16(23-7-10)30-8-12-13(26)3-4-25(12)17(11)27/h1-2,5-7,12-13,24,26H,3-4,8H2/t12-,13-/m0/s1
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n/an/a 0.400n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508496
PNG
(5-chloro-N-[(9S,9aS)-9-hydroxy-5-oxo-8,9,9a,10-tet...)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OC[C@H]3[C@@H](O)CCN3C(=O)c2c1
Show InChI InChI=1S/C18H18ClN3O6S/c1-27-15-3-2-10(19)6-16(15)29(25,26)21-11-7-12-17(20-8-11)28-9-13-14(23)4-5-22(13)18(12)24/h2-3,6-8,13-14,21,23H,4-5,9H2,1H3/t13-,14-/m0/s1
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n/an/a 0.400n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508500
PNG
(5-chloro-2-methoxy-N-[(8S,9aR)-8-methoxy-5-oxo-8,9...)
Show SMILES CO[C@H]1C[C@@H]2COc3ncc(NS(=O)(=O)c4cc(Cl)ccc4OC)cc3C(=O)N2C1
Show InChI InChI=1S/C19H20ClN3O6S/c1-27-14-7-13-10-29-18-15(19(24)23(13)9-14)6-12(8-21-18)22-30(25,26)17-5-11(20)3-4-16(17)28-2/h3-6,8,13-14,22H,7,9-10H2,1-2H3/t13-,14+/m1/s1
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n/an/a 0.5n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508503
PNG
(US11046710, Example 50 | methyl [(8R,9aR)-3-{[(5-c...)
Show SMILES COC(=O)N[C@@H]1C[C@@H]2COc3ncc(NS(=O)(=O)c4cc(Cl)ccc4OC)cc3C(=O)N2C1
Show InChI InChI=1S/C20H21ClN4O7S/c1-30-16-4-3-11(21)5-17(16)33(28,29)24-12-7-15-18(22-8-12)32-10-14-6-13(23-20(27)31-2)9-25(14)19(15)26/h3-5,7-8,13-14,24H,6,9-10H2,1-2H3,(H,23,27)/t13-,14-/m1/s1
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Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508502
PNG
((8S,9aR)-3-{[(5-chloro-2-methoxyphenyl)sulfonyl]am...)
Show SMILES COC(=O)N[C@H]1C[C@@H]2COc3ncc(NS(=O)(=O)c4cc(Cl)ccc4OC)cc3C(=O)N2C1
Show InChI InChI=1S/C20H21ClN4O7S/c1-30-16-4-3-11(21)5-17(16)33(28,29)24-12-7-15-18(22-8-12)32-10-14-6-13(23-20(27)31-2)9-25(14)19(15)26/h3-5,7-8,13-14,24H,6,9-10H2,1-2H3,(H,23,27)/t13-,14+/m0/s1
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n/an/a 0.600n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508512
PNG
(2-ethoxy-5-fluoro-N-[(10aS)-7-oxo-7,8,10a,11-tetra...)
Show SMILES CCOc1ccc(F)cc1S(=O)(=O)Nc1cnc2OC[C@@H]3COC(=O)CN3Cc2c1
Show InChI InChI=1S/C19H20FN3O6S/c1-2-27-16-4-3-13(20)6-17(16)30(25,26)22-14-5-12-8-23-9-18(24)28-10-15(23)11-29-19(12)21-7-14/h3-7,15,22H,2,8-11H2,1H3/t15-/m0/s1
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n/an/a 0.600n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508498
PNG
(5-chloro-N-[(8S,9aR)-8-fluoro-5-oxo-8,9,9a,10-tetr...)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OC[C@H]3C[C@H](F)CN3C(=O)c2c1
Show InChI InChI=1S/C18H17ClFN3O5S/c1-27-15-3-2-10(19)4-16(15)29(25,26)22-12-6-14-17(21-7-12)28-9-13-5-11(20)8-23(13)18(14)24/h2-4,6-7,11,13,22H,5,8-9H2,1H3/t11-,13+/m0/s1
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Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508491
PNG
(US11046710, Example 35)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OC[C@H]3C[C@@H](O)CN3C(=O)c2c1
Show InChI InChI=1S/C18H18ClN3O6S/c1-27-15-3-2-10(19)4-16(15)29(25,26)21-11-5-14-17(20-7-11)28-9-12-6-13(23)8-22(12)18(14)24/h2-5,7,12-13,21,23H,6,8-9H2,1H3/t12-,13-/m1/s1
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Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508487
PNG
(US11046710, Example 30)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OC[C@H]3C[C@H](O)CN3C(=O)c2c1
Show InChI InChI=1S/C18H18ClN3O6S/c1-27-15-3-2-10(19)4-16(15)29(25,26)21-11-5-14-17(20-7-11)28-9-12-6-13(23)8-22(12)18(14)24/h2-5,7,12-13,21,23H,6,8-9H2,1H3/t12-,13+/m1/s1
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Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508489
PNG
(US11046710, Example 32)
Show SMILES O[C@H]1C[C@@H]2COc3ncc(NS(=O)(=O)c4cc(Cl)ccc4OC(F)(F)F)cc3C(=O)N2C1
Show InChI InChI=1S/C18H15ClF3N3O6S/c19-9-1-2-14(31-18(20,21)22)15(3-9)32(28,29)24-10-4-13-16(23-6-10)30-8-11-5-12(26)7-25(11)17(13)27/h1-4,6,11-12,24,26H,5,7-8H2/t11-,12+/m1/s1
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n/an/a 0.900n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508506
PNG
(US11046710, Example 54)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OC[C@@H]3C[C@H](O)C(=O)N3Cc2c1
Show InChI InChI=1S/C18H18ClN3O6S/c1-27-15-3-2-11(19)5-16(15)29(25,26)21-12-4-10-8-22-13(6-14(23)18(22)24)9-28-17(10)20-7-12/h2-5,7,13-14,21,23H,6,8-9H2,1H3/t13-,14-/m0/s1
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Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508485
PNG
(US11046710, Example 28)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OC[C@H]3CCCN3C(=O)c2c1
Show InChI InChI=1S/C18H18ClN3O5S/c1-26-15-5-4-11(19)7-16(15)28(24,25)21-12-8-14-17(20-9-12)27-10-13-3-2-6-22(13)18(14)23/h4-5,7-9,13,21H,2-3,6,10H2,1H3/t13-/m1/s1
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Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508488
PNG
(US11046710, Example 31)
Show SMILES COc1ccc(F)cc1S(=O)(=O)Nc1cnc2OC[C@H]3C[C@H](O)CN3C(=O)c2c1
Show InChI InChI=1S/C18H18FN3O6S/c1-27-15-3-2-10(19)4-16(15)29(25,26)21-11-5-14-17(20-7-11)28-9-12-6-13(23)8-22(12)18(14)24/h2-5,7,12-13,21,23H,6,8-9H2,1H3/t12-,13+/m1/s1
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Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508513
PNG
(US11046710, Example 63)
Show SMILES COc1ccc(F)cc1S(=O)(=O)Nc1cnc2OC[C@@H]3CNC(=O)CN3Cc2c1
Show InChI InChI=1S/C18H19FN4O5S/c1-27-15-3-2-12(19)5-16(15)29(25,26)22-13-4-11-8-23-9-17(24)20-7-14(23)10-28-18(11)21-6-13/h2-6,14,22H,7-10H2,1H3,(H,20,24)/t14-/m0/s1
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Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508493
PNG
(US11046710, Example 37)
Show SMILES O[C@@H]1C[C@@H]2COc3ncc(NS(=O)(=O)c4cc(Cl)ccc4OC(F)(F)F)cc3C(=O)N2C1
Show InChI InChI=1S/C18H15ClF3N3O6S/c19-9-1-2-14(31-18(20,21)22)15(3-9)32(28,29)24-10-4-13-16(23-6-10)30-8-11-5-12(26)7-25(11)17(13)27/h1-4,6,11-12,24,26H,5,7-8H2/t11-,12-/m1/s1
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Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508507
PNG
(5-chloro-N-[(8S,9aS)-8-hydroxy-7-oxo-8,9,9a,10-tet...)
Show SMILES O[C@H]1C[C@H]2COc3ncc(NS(=O)(=O)c4cc(Cl)ccc4OC(F)(F)F)cc3CN2C1=O
Show InChI InChI=1S/C18H15ClF3N3O6S/c19-10-1-2-14(31-18(20,21)22)15(4-10)32(28,29)24-11-3-9-7-25-12(5-13(26)17(25)27)8-30-16(9)23-6-11/h1-4,6,12-13,24,26H,5,7-8H2/t12-,13-/m0/s1
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Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508510
PNG
(5-chloro-2-methoxy-N-[(10aS)-7-oxo-7,8,9,10,10a, 1...)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OC[C@@H]3CCCC(=O)N3Cc2c1
Show InChI InChI=1S/C19H20ClN3O5S/c1-27-16-6-5-13(20)8-17(16)29(25,26)22-14-7-12-10-23-15(3-2-4-18(23)24)11-28-19(12)21-9-14/h5-9,15,22H,2-4,10-11H2,1H3/t15-/m0/s1
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Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508501
PNG
((8S,9aR)-3-({[5-chloro-2-(trifluoromethoxy)phenyl]...)
Show SMILES CC(=O)O[C@H]1C[C@@H]2COc3ncc(NS(=O)(=O)c4cc(Cl)ccc4OC(F)(F)F)cc3C(=O)N2C1
Show InChI InChI=1S/C20H17ClF3N3O7S/c1-10(28)33-14-6-13-9-32-18-15(19(29)27(13)8-14)5-12(7-25-18)26-35(30,31)17-4-11(21)2-3-16(17)34-20(22,23)24/h2-5,7,13-14,26H,6,8-9H2,1H3/t13-,14+/m1/s1
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Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508492
PNG
(US11046710, Example 36)
Show SMILES COc1ccc(F)cc1S(=O)(=O)Nc1cnc2OC[C@H]3C[C@@H](O)CN3C(=O)c2c1
Show InChI InChI=1S/C18H18FN3O6S/c1-27-15-3-2-10(19)4-16(15)29(25,26)21-11-5-14-17(20-7-11)28-9-12-6-13(23)8-22(12)18(14)24/h2-5,7,12-13,21,23H,6,8-9H2,1H3/t12-,13-/m1/s1
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US Patent
n/an/a 1.5n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508490
PNG
(US11046710, Example 34)
Show SMILES O[C@H]1C[C@@H]2COc3ncc(NS(=O)(=O)c4cc(F)ccc4OC(F)(F)F)cc3C(=O)N2C1
Show InChI InChI=1S/C18H15F4N3O6S/c19-9-1-2-14(31-18(20,21)22)15(3-9)32(28,29)24-10-4-13-16(23-6-10)30-8-11-5-12(26)7-25(11)17(13)27/h1-4,6,11-12,24,26H,5,7-8H2/t11-,12+/m1/s1
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n/an/a 1.60n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508514
PNG
(5-chloro-2-methoxy-N-[(10aS)-9-methyl-7-oxo-7,8,9,...)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OC[C@H]3CNC(=O)CN3Cc2c1
Show InChI InChI=1S/C18H19ClN4O5S/c1-27-15-3-2-12(19)5-16(15)29(25,26)22-13-4-11-8-23-9-17(24)20-7-14(23)10-28-18(11)21-6-13/h2-6,14,22H,7-10H2,1H3,(H,20,24)/t14-/m1/s1
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n/an/a 1.80n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508499
PNG
(5-chloro-N-[(9aR)-8,8-difluoro-5-oxo-8,9,9a,10-tet...)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OC[C@H]3CC(F)(F)CN3C(=O)c2c1
Show InChI InChI=1S/C18H16ClF2N3O5S/c1-28-14-3-2-10(19)4-15(14)30(26,27)23-11-5-13-16(22-7-11)29-8-12-6-18(20,21)9-24(12)17(13)25/h2-5,7,12,23H,6,8-9H2,1H3/t12-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508504
PNG
(5-chloro-2-methoxy-N-[(9aS)-7-oxo-8,9,9a,10-tetrah...)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OC[C@@H]3CCC(=O)N3Cc2c1
Show InChI InChI=1S/C18H18ClN3O5S/c1-26-15-4-2-12(19)7-16(15)28(24,25)21-13-6-11-9-22-14(3-5-17(22)23)10-27-18(11)20-8-13/h2,4,6-8,14,21H,3,5,9-10H2,1H3/t14-/m0/s1
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n/an/a 2.20n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508482
PNG
(US11046710, Example 24)
Show SMILES CCOc1ncc(F)cc1S(=O)(=O)Nc1cnc2OC[C@H](C)n3nccc3-c2c1
Show InChI InChI=1S/C18H18FN5O4S/c1-3-27-18-16(6-12(19)8-20-18)29(25,26)23-13-7-14-15-4-5-22-24(15)11(2)10-28-17(14)21-9-13/h4-9,11,23H,3,10H2,1-2H3/t11-/m0/s1
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n/an/a 2.30n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508467
PNG
(US11046710, Example 3)
Show SMILES CCc1nnc2-c3cc(NS(=O)(=O)c4cc(Cl)ccc4OC)cnc3OCCn12
Show InChI InChI=1S/C18H18ClN5O4S/c1-3-16-21-22-17-13-9-12(10-20-18(13)28-7-6-24(16)17)23-29(25,26)15-8-11(19)4-5-14(15)27-2/h4-5,8-10,23H,3,6-7H2,1-2H3
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n/an/a 2.40n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508494
PNG
(5-fluoro-N-[(8R,9aR)-8-hydroxy-5-oxo-8,9,9a,10-tet...)
Show SMILES O[C@@H]1C[C@@H]2COc3ncc([N-]S(=O)(=O)c4cc(F)ccc4OC(F)(F)F)cc3C(=O)N2C1
Show InChI InChI=1S/C18H14F4N3O6S/c19-9-1-2-14(31-18(20,21)22)15(3-9)32(28,29)24-10-4-13-16(23-6-10)30-8-11-5-12(26)7-25(11)17(13)27/h1-4,6,11-12,26H,5,7-8H2/q-1/t11-,12-/m1/s1
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n/an/a 2.40n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508466
PNG
(US11046710, Example 1)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OCCn3c(C)nnc3-c2c1
Show InChI InChI=1S/C17H16ClN5O4S/c1-10-20-21-16-13-8-12(9-19-17(13)27-6-5-23(10)16)22-28(24,25)15-7-11(18)3-4-14(15)26-2/h3-4,7-9,22H,5-6H2,1-2H3
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n/an/a 2.60n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508478
PNG
(US11046710, Example 18)
Show SMILES CCOc1ccc(F)cc1S(=O)(=O)Nc1cnc2OC[C@H](C)n3nccc3-c2c1
Show InChI InChI=1S/C19H19FN4O4S/c1-3-27-17-5-4-13(20)8-18(17)29(25,26)23-14-9-15-16-6-7-22-24(16)12(2)11-28-19(15)21-10-14/h4-10,12,23H,3,11H2,1-2H3/t12-/m0/s1
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n/an/a 2.80n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508468
PNG
(US11046710, Example 5)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OCCn3c(nnc3-c2c1)C(C)C
Show InChI InChI=1S/C19H20ClN5O4S/c1-11(2)17-22-23-18-14-9-13(10-21-19(14)29-7-6-25(17)18)24-30(26,27)16-8-12(20)4-5-15(16)28-3/h4-5,8-11,24H,6-7H2,1-3H3
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n/an/a 2.80n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508480
PNG
(US11046710, Example 21)
Show SMILES COc1ncc(Cl)cc1S(=O)(=O)Nc1cnc2OC[C@H](C)n3nccc3-c2c1
Show InChI InChI=1S/C17H16ClN5O4S/c1-10-9-27-16-13(14-3-4-21-23(10)14)6-12(8-20-16)22-28(24,25)15-5-11(18)7-19-17(15)26-2/h3-8,10,22H,9H2,1-2H3/t10-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508511
PNG
(US11046710, Example 60)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OC[C@@H]3COC(=O)CN3Cc2c1
Show InChI InChI=1S/C18H18ClN3O6S/c1-26-15-3-2-12(19)5-16(15)29(24,25)21-13-4-11-7-22-8-17(23)27-9-14(22)10-28-18(11)20-6-13/h2-6,14,21H,7-10H2,1H3/t14-/m0/s1
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n/an/a 3.30n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508471
PNG
(US11046710, Example 9)
Show SMILES CCOc1ccc(F)cc1S(=O)(=O)Nc1cnc2OCCn3nccc3-c2c1
Show InChI InChI=1S/C18H17FN4O4S/c1-2-26-16-4-3-12(19)9-17(16)28(24,25)22-13-10-14-15-5-6-21-23(15)7-8-27-18(14)20-11-13/h3-6,9-11,22H,2,7-8H2,1H3
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n/an/a 3.40n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508476
PNG
(US11046710, Example 16)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OC[C@H](C)n3nccc3-c2c1
Show InChI InChI=1S/C18H17ClN4O4S/c1-11-10-27-18-14(15-5-6-21-23(11)15)8-13(9-20-18)22-28(24,25)17-7-12(19)3-4-16(17)26-2/h3-9,11,22H,10H2,1-2H3/t11-/m0/s1
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n/an/a 3.5n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508475
PNG
(US11046710, Example 14)
Show SMILES CCOc1ncc(F)cc1S(=O)(=O)Nc1cnc2OCCn3nccc3-c2c1
Show InChI InChI=1S/C17H16FN5O4S/c1-2-26-17-15(7-11(18)9-19-17)28(24,25)22-12-8-13-14-3-4-21-23(14)5-6-27-16(13)20-10-12/h3-4,7-10,22H,2,5-6H2,1H3
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n/an/a 3.60n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508508
PNG
(5-chloro-2-methoxy-N-[(9aR)-7-oxo-9a,10-dihydro-5H...)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OC[C@@H]3COC(=O)N3Cc2c1
Show InChI InChI=1S/C17H16ClN3O6S/c1-25-14-3-2-11(18)5-15(14)28(23,24)20-12-4-10-7-21-13(9-27-17(21)22)8-26-16(10)19-6-12/h2-6,13,20H,7-9H2,1H3/t13-/m1/s1
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n/an/a 3.80n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508479
PNG
(US11046710, Example 20)
Show SMILES CCOc1ccc(F)cc1S(=O)(=O)Nc1cnc2OC[C@@H](C)n3nccc3-c2c1
Show InChI InChI=1S/C19H19FN4O4S/c1-3-27-17-5-4-13(20)8-18(17)29(25,26)23-14-9-15-16-6-7-22-24(16)12(2)11-28-19(15)21-10-14/h4-10,12,23H,3,11H2,1-2H3/t12-/m1/s1
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n/an/a 4.20n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508505
PNG
(5-chloro-N-[(8R,9aS)-8-hydroxy-7-oxo-8,9,9a,10-tet...)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OC[C@@H]3C[C@@H](O)C(=O)N3Cc2c1
Show InChI InChI=1S/C18H18ClN3O6S/c1-27-15-3-2-11(19)5-16(15)29(25,26)21-12-4-10-8-22-13(6-14(23)18(22)24)9-28-17(10)20-7-12/h2-5,7,13-14,21,23H,6,8-9H2,1H3/t13-,14+/m0/s1
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n/an/a 4.30n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508474
PNG
(US11046710, Example 13)
Show SMILES CCOc1ncc(Cl)cc1S(=O)(=O)Nc1cnc2OCCn3nccc3-c2c1
Show InChI InChI=1S/C17H16ClN5O4S/c1-2-26-17-15(7-11(18)9-19-17)28(24,25)22-12-8-13-14-3-4-21-23(14)5-6-27-16(13)20-10-12/h3-4,7-10,22H,2,5-6H2,1H3
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n/an/a 5.10n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508481
PNG
(US11046710, Example 23)
Show SMILES COc1ncc(Cl)cc1S(=O)(=O)Nc1cnc2OC[C@@H](C)n3nccc3-c2c1
Show InChI InChI=1S/C17H16ClN5O4S/c1-10-9-27-16-13(14-3-4-21-23(10)14)6-12(8-20-16)22-28(24,25)15-5-11(18)7-19-17(15)26-2/h3-8,10,22H,9H2,1-2H3/t10-/m1/s1
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n/an/a 5.70n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508495
PNG
(5-chloro-N-[(9R,9aS)-9-hydroxy-5-oxo-8,9,9a,10-tet...)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OC[C@H]3[C@H](O)CCN3C(=O)c2c1
Show InChI InChI=1S/C18H18ClN3O6S/c1-27-15-3-2-10(19)6-16(15)29(25,26)21-11-7-12-17(20-8-11)28-9-13-14(23)4-5-22(13)18(12)24/h2-3,6-8,13-14,21,23H,4-5,9H2,1H3/t13-,14+/m0/s1
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n/an/a 5.80n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508469
PNG
(US11046710, Example 6)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OCCn3ccnc3-c2c1
Show InChI InChI=1S/C17H15ClN4O4S/c1-25-14-3-2-11(18)8-15(14)27(23,24)21-12-9-13-16-19-4-5-22(16)6-7-26-17(13)20-10-12/h2-5,8-10,21H,6-7H2,1H3
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n/an/a 5.90n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508470
PNG
(US11046710, Example 7)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OCCn3nccc3-c2c1
Show InChI InChI=1S/C17H15ClN4O4S/c1-25-15-3-2-11(18)8-16(15)27(23,24)21-12-9-13-14-4-5-20-22(14)6-7-26-17(13)19-10-12/h2-5,8-10,21H,6-7H2,1H3
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n/an/a 6.5n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508477
PNG
(US11046710, Example 17)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OC[C@@H](C)n3nccc3-c2c1
Show InChI InChI=1S/C18H17ClN4O4S/c1-11-10-27-18-14(15-5-6-21-23(11)15)8-13(9-20-18)22-28(24,25)17-7-12(19)3-4-16(17)26-2/h3-9,11,22H,10H2,1-2H3/t11-/m1/s1
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n/an/a 6.90n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508486
PNG
(US11046710, Example 29)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OC[C@@H]3C[C@@H](O)CN3C(=O)c2c1
Show InChI InChI=1S/C18H18ClN3O6S/c1-27-15-3-2-10(19)4-16(15)29(25,26)21-11-5-14-17(20-7-11)28-9-12-6-13(23)8-22(12)18(14)24/h2-5,7,12-13,21,23H,6,8-9H2,1H3/t12-,13+/m0/s1
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n/an/a 7.10n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508473
PNG
(US11046710, Example 12)
Show SMILES COc1ncc(Cl)cc1S(=O)(=O)Nc1cnc2OCCn3nccc3-c2c1
Show InChI InChI=1S/C16H14ClN5O4S/c1-25-16-14(6-10(17)8-18-16)27(23,24)21-11-7-12-13-2-3-20-22(13)4-5-26-15(12)19-9-11/h2-3,6-9,21H,4-5H2,1H3
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n/an/a 8.5n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508472
PNG
(US11046710, Example 11)
Show SMILES COCCOc1ccc(F)cc1S(=O)(=O)Nc1cnc2OCCn3nccc3-c2c1
Show InChI InChI=1S/C19H19FN4O5S/c1-27-8-9-28-17-3-2-13(20)10-18(17)30(25,26)23-14-11-15-16-4-5-22-24(16)6-7-29-19(15)21-12-14/h2-5,10-12,23H,6-9H2,1H3
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n/an/a 12.6n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508484
PNG
(US11046710, Example 27)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OC[C@@H]3CCCN3C(=O)c2c1
Show InChI InChI=1S/C18H18ClN3O5S/c1-26-15-5-4-11(19)7-16(15)28(24,25)21-12-8-14-17(20-9-12)27-10-13-3-2-6-22(13)18(14)23/h4-5,7-9,13,21H,2-3,6,10H2,1H3/t13-/m0/s1
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n/an/a 13.2n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM508483
PNG
(US11046710, Example 26)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OCCc3ccnn3-c2c1
Show InChI InChI=1S/C17H15ClN4O4S/c1-25-15-3-2-11(18)8-16(15)27(23,24)21-12-9-14-17(19-10-12)26-7-5-13-4-6-20-22(13)14/h2-4,6,8-10,21H,5,7H2,1H3
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n/an/a 29.4n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US11046710 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%