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Patent code US11046725

Compile Data Set for Download or QSAR
Found 52 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Galectin-3


(Homo sapiens (Human))
BDBM508730
PNG
(5-Chloro-6-cyano-pyridine-3-yl 3-[4-(4-chlorothiaz...)
Show SMILES OCC1O[C@H](Sc2cnc(C#N)c(Cl)c2)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1nc(Cl)cs1
Show InChI InChI=1S/C17H14Cl2N6O4S2/c18-8-1-7(3-21-9(8)2-20)31-17-15(28)13(14(27)11(5-26)29-17)25-4-10(23-24-25)16-22-12(19)6-30-16/h1,3-4,6,11,13-15,17,26-28H,5H2/t11?,13-,14-,15?,17+/m0/s1
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n/an/an/a 420n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-3


(Homo sapiens (Human))
BDBM508747
PNG
(3-Chloro-4-trifluoromethylphenyl 3-deoxy-3-[4-(2-h...)
Show SMILES OCC1O[C@H](Sc2ccc(c(Cl)c2)C(F)(F)F)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C18H16ClF3N4O5S2/c19-9-3-7(1-2-8(9)18(20,21)22)33-16-15(29)13(14(28)12(5-27)31-16)26-4-10(24-25-26)11-6-32-17(30)23-11/h1-4,6,12-16,27-29H,5H2,(H,23,30)/t12?,13-,14-,15?,16+/m0/s1
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n/an/an/a 6.50E+3n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM508737
PNG
(5-Chloro-6-cyano-pyridine-3-yl 3-deoxy-3-[4-(2-hyd...)
Show SMILES OCC1O[C@H](Sc2cnc(Cl)c(Cl)c2)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C16H15Cl2N5O5S2/c17-7-1-6(2-19-14(7)18)30-15-13(26)11(12(25)10(4-24)28-15)23-3-8(21-22-23)9-5-29-16(27)20-9/h1-3,5,10-13,15,24-26H,4H2,(H,20,27)/t10?,11-,12-,13?,15+/m0/s1
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n/an/an/a 38n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM508740
PNG
(5-Chloro-2-cyano-3-pyridyl 3-deoxy-3-[4-(2-hydroxy...)
Show SMILES OCC1O[C@H](Sc2cc(Cl)cnc2C#N)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C17H15ClN6O5S2/c18-7-1-12(8(2-19)20-3-7)31-16-15(27)13(14(26)11(5-25)29-16)24-4-9(22-23-24)10-6-30-17(28)21-10/h1,3-4,6,11,13-16,25-27H,5H2,(H,21,28)/t11?,13-,14-,15?,16+/m0/s1
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n/an/an/a 6n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-3


(Homo sapiens (Human))
BDBM508745
PNG
(3-Bromo-4-cyanophenyl 3-deoxy-3-[4-(2-hydroxythiaz...)
Show SMILES OCC1O[C@H](Sc2ccc(C#N)c(Br)c2)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C18H16BrN5O5S2/c19-10-3-9(2-1-8(10)4-20)31-17-16(27)14(15(26)13(6-25)29-17)24-5-11(22-23-24)12-7-30-18(28)21-12/h1-3,5,7,13-17,25-27H,6H2,(H,21,28)/t13?,14-,15-,16?,17+/m0/s1
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n/an/an/a 6.00E+3n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-3


(Homo sapiens (Human))
BDBM508751
PNG
(3,4-Dichloro-6-fluoro-phenyl 3-deoxy-3-[4-(2-hydro...)
Show SMILES OCC1O[C@H](Sc2cc(Cl)c(Cl)cc2F)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C17H15Cl2FN4O5S2/c18-6-1-8(20)12(2-7(6)19)31-16-15(27)13(14(26)11(4-25)29-16)24-3-9(22-23-24)10-5-30-17(28)21-10/h1-3,5,11,13-16,25-27H,4H2,(H,21,28)/t11?,13-,14-,15?,16+/m0/s1
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n/an/an/a 4.60E+3n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM508753
PNG
(5-Chloro-N,N′-dimethyl-picolinamide-3-yl 3-d...)
Show SMILES CN(C)C(=O)c1ncc(Cl)cc1S[C@H]1OC(CO)[C@H](O)[C@@H](C1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C19H21ClN6O6S2/c1-25(2)17(30)13-12(3-8(20)4-21-13)34-18-16(29)14(15(28)11(6-27)32-18)26-5-9(23-24-26)10-7-33-19(31)22-10/h3-5,7,11,14-16,18,27-29H,6H2,1-2H3,(H,22,31)/t11?,14-,15-,16?,18+/m0/s1
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n/an/an/a 54n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-3


(Homo sapiens (Human))
BDBM508729
PNG
(5-Bromo-6-trifluoromethyl-pyridine-3-yl 3-[4-(4-br...)
Show SMILES OCC1O[C@H](Sc2cnc(c(Br)c2)C(F)(F)F)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1nc(Br)cs1
Show InChI InChI=1S/C17H14Br2F3N5O4S2/c18-7-1-6(2-23-14(7)17(20,21)22)33-16-13(30)11(12(29)9(4-28)31-16)27-3-8(25-26-27)15-24-10(19)5-32-15/h1-3,5,9,11-13,16,28-30H,4H2/t9?,11-,12-,13?,16+/m0/s1
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n/an/an/a 580n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM508731
PNG
(5-Bromo-2-cyano-pyridine-3-yl 3-[4-(4-chlorothiazo...)
Show SMILES OCC1O[C@H](Sc2cc(Br)cnc2C#N)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1nc(Cl)cs1
Show InChI InChI=1S/C17H14BrClN6O4S2/c18-7-1-11(8(2-20)21-3-7)31-17-15(28)13(14(27)10(5-26)29-17)25-4-9(23-24-25)16-22-12(19)6-30-16/h1,3-4,6,10,13-15,17,26-28H,5H2/t10?,13-,14-,15?,17+/m0/s1
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GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM508732
PNG
(5-Chloro-2-cyano-pyridine-3-yl 3-[4-(4-chlorothiaz...)
Show SMILES OCC1O[C@H](Sc2cc(Cl)cnc2C#N)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1nc(Cl)cs1
Show InChI InChI=1S/C17H14Cl2N6O4S2/c18-7-1-11(8(2-20)21-3-7)31-17-15(28)13(14(27)10(5-26)29-17)25-4-9(23-24-25)16-22-12(19)6-30-16/h1,3-4,6,10,13-15,17,26-28H,5H2/t10?,13-,14-,15?,17+/m0/s1
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n/an/an/a 95n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-3


(Homo sapiens (Human))
BDBM508738
PNG
(5-Bromo-2-cyano-pyridine-3-yl 3-deoxy-3-[4-(2-hydr...)
Show SMILES OCC1O[C@H](Sc2cc(Br)cnc2C#N)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C17H15BrN6O5S2/c18-7-1-12(8(2-19)20-3-7)31-16-15(27)13(14(26)11(5-25)29-16)24-4-9(22-23-24)10-6-30-17(28)21-10/h1,3-4,6,11,13-16,25-27H,5H2,(H,21,28)/t11?,13-,14-,15?,16+/m0/s1
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n/an/an/a 2.60E+3n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-3


(Homo sapiens (Human))
BDBM508743
PNG
(3,4,5-trichlorophenyl 3-deoxy-3-[4-(2-hydroxythiaz...)
Show SMILES OCC1O[C@H](Sc2cc(Cl)c(Cl)c(Cl)c2)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C17H15Cl3N4O5S2/c18-7-1-6(2-8(19)12(7)20)31-16-15(27)13(14(26)11(4-25)29-16)24-3-9(22-23-24)10-5-30-17(28)21-10/h1-3,5,11,13-16,25-27H,4H2,(H,21,28)/t11?,13-,14-,15?,16+/m0/s1
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n/an/an/a 6.00E+3n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM508745
PNG
(3-Bromo-4-cyanophenyl 3-deoxy-3-[4-(2-hydroxythiaz...)
Show SMILES OCC1O[C@H](Sc2ccc(C#N)c(Br)c2)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C18H16BrN5O5S2/c19-10-3-9(2-1-8(10)4-20)31-17-16(27)14(15(26)13(6-25)29-17)24-5-11(22-23-24)12-7-30-18(28)21-12/h1-3,5,7,13-17,25-27H,6H2,(H,21,28)/t13?,14-,15-,16?,17+/m0/s1
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n/an/an/a 63n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM508747
PNG
(3-Chloro-4-trifluoromethylphenyl 3-deoxy-3-[4-(2-h...)
Show SMILES OCC1O[C@H](Sc2ccc(c(Cl)c2)C(F)(F)F)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C18H16ClF3N4O5S2/c19-9-3-7(1-2-8(9)18(20,21)22)33-16-15(29)13(14(28)12(5-27)31-16)26-4-10(24-25-26)11-6-32-17(30)23-11/h1-4,6,12-16,27-29H,5H2,(H,23,30)/t12?,13-,14-,15?,16+/m0/s1
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n/an/an/a 71n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM508751
PNG
(3,4-Dichloro-6-fluoro-phenyl 3-deoxy-3-[4-(2-hydro...)
Show SMILES OCC1O[C@H](Sc2cc(Cl)c(Cl)cc2F)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C17H15Cl2FN4O5S2/c18-6-1-8(20)12(2-7(6)19)31-16-15(27)13(14(26)11(4-25)29-16)24-3-9(22-23-24)10-5-30-17(28)21-10/h1-3,5,11,13-16,25-27H,4H2,(H,21,28)/t11?,13-,14-,15?,16+/m0/s1
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n/an/an/a 13n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM508730
PNG
(5-Chloro-6-cyano-pyridine-3-yl 3-[4-(4-chlorothiaz...)
Show SMILES OCC1O[C@H](Sc2cnc(C#N)c(Cl)c2)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1nc(Cl)cs1
Show InChI InChI=1S/C17H14Cl2N6O4S2/c18-8-1-7(3-21-9(8)2-20)31-17-15(28)13(14(27)11(5-26)29-17)25-4-10(23-24-25)16-22-12(19)6-30-16/h1,3-4,6,11,13-15,17,26-28H,5H2/t11?,13-,14-,15?,17+/m0/s1
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n/an/an/a 95n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM508733
PNG
(5-Bromo-6-cyano-3-pyridyl 3-[4-(4-chlorothiazol-2-...)
Show SMILES OCC1O[C@H](Sc2cnc(C#N)c(Br)c2)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1nc(Cl)cs1
Show InChI InChI=1S/C17H14BrClN6O4S2/c18-8-1-7(3-21-9(8)2-20)31-17-15(28)13(14(27)11(5-26)29-17)25-4-10(23-24-25)16-22-12(19)6-30-16/h1,3-4,6,11,13-15,17,26-28H,5H2/t11?,13-,14-,15?,17+/m0/s1
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n/an/an/a 68n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM508738
PNG
(5-Bromo-2-cyano-pyridine-3-yl 3-deoxy-3-[4-(2-hydr...)
Show SMILES OCC1O[C@H](Sc2cc(Br)cnc2C#N)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C17H15BrN6O5S2/c18-7-1-12(8(2-19)20-3-7)31-16-15(27)13(14(26)11(5-25)29-16)24-4-9(22-23-24)10-6-30-17(28)21-10/h1,3-4,6,11,13-16,25-27H,5H2,(H,21,28)/t11?,13-,14-,15?,16+/m0/s1
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n/an/an/a 33n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM508739
PNG
(5-Bromo-6-cyano-3-pyridyl 3-deoxy-3-[4-(2-hydroxyt...)
Show SMILES OCC1O[C@H](Sc2cnc(C#N)c(Br)c2)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C17H15BrN6O5S2/c18-8-1-7(3-20-9(8)2-19)31-16-15(27)13(14(26)12(5-25)29-16)24-4-10(22-23-24)11-6-30-17(28)21-11/h1,3-4,6,12-16,25-27H,5H2,(H,21,28)/t12?,13-,14-,15?,16+/m0/s1
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n/an/an/a 19n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-3


(Homo sapiens (Human))
BDBM508739
PNG
(5-Bromo-6-cyano-3-pyridyl 3-deoxy-3-[4-(2-hydroxyt...)
Show SMILES OCC1O[C@H](Sc2cnc(C#N)c(Br)c2)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C17H15BrN6O5S2/c18-8-1-7(3-20-9(8)2-19)31-16-15(27)13(14(26)12(5-25)29-16)24-4-10(22-23-24)11-6-30-17(28)21-11/h1,3-4,6,12-16,25-27H,5H2,(H,21,28)/t12?,13-,14-,15?,16+/m0/s1
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n/an/an/a 2.80E+3n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM508743
PNG
(3,4,5-trichlorophenyl 3-deoxy-3-[4-(2-hydroxythiaz...)
Show SMILES OCC1O[C@H](Sc2cc(Cl)c(Cl)c(Cl)c2)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C17H15Cl3N4O5S2/c18-7-1-6(2-8(19)12(7)20)31-16-15(27)13(14(26)11(4-25)29-16)24-3-9(22-23-24)10-5-30-17(28)21-10/h1-3,5,11,13-16,25-27H,4H2,(H,21,28)/t11?,13-,14-,15?,16+/m0/s1
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n/an/an/a 56n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-3


(Homo sapiens (Human))
BDBM508746
PNG
(5-Bromo-6-trifluoromethyl-3-pyridyl 3-deoxy-3-[4-(...)
Show SMILES OCC1O[C@H](Sc2cnc(c(Br)c2)C(F)(F)F)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C17H15BrF3N5O5S2/c18-7-1-6(2-22-14(7)17(19,20)21)33-15-13(29)11(12(28)10(4-27)31-15)26-3-8(24-25-26)9-5-32-16(30)23-9/h1-3,5,10-13,15,27-29H,4H2,(H,23,30)/t10?,11-,12-,13?,15+/m0/s1
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n/an/an/a 3.10E+3n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM508748
PNG
(3-Chloro-4-methylphenyl 3-deoxy-3-[4-(2-hydroxythi...)
Show SMILES Cc1ccc(S[C@H]2OC(CO)[C@H](O)[C@@H](C2O)n2cc(nn2)-c2csc(O)n2)cc1Cl
Show InChI InChI=1S/C18H19ClN4O5S2/c1-8-2-3-9(4-10(8)19)30-17-16(26)14(15(25)13(6-24)28-17)23-5-11(21-22-23)12-7-29-18(27)20-12/h2-5,7,13-17,24-26H,6H2,1H3,(H,20,27)/t13?,14-,15-,16?,17+/m0/s1
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n/an/an/a 82n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-3


(Homo sapiens (Human))
BDBM508748
PNG
(3-Chloro-4-methylphenyl 3-deoxy-3-[4-(2-hydroxythi...)
Show SMILES Cc1ccc(S[C@H]2OC(CO)[C@H](O)[C@@H](C2O)n2cc(nn2)-c2csc(O)n2)cc1Cl
Show InChI InChI=1S/C18H19ClN4O5S2/c1-8-2-3-9(4-10(8)19)30-17-16(26)14(15(25)13(6-24)28-17)23-5-11(21-22-23)12-7-29-18(27)20-12/h2-5,7,13-17,24-26H,6H2,1H3,(H,20,27)/t13?,14-,15-,16?,17+/m0/s1
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n/an/an/a 6.60E+3n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-3


(Homo sapiens (Human))
BDBM508750
PNG
(5-Bromo-6-trifluoromethyl-pyridine-3-yl 3-deoxy-3-...)
Show SMILES OCC1O[C@H](Sc2cnc(c(Br)c2)C(F)(F)F)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1nc(Cl)c(Cl)s1
Show InChI InChI=1S/C17H13BrCl2F3N5O4S2/c18-6-1-5(2-24-12(6)17(21,22)23)33-16-11(31)9(10(30)8(4-29)32-16)28-3-7(26-27-28)15-25-13(19)14(20)34-15/h1-3,8-11,16,29-31H,4H2/t8?,9-,10-,11?,16+/m0/s1
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n/an/an/a 69n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM508752
PNG
(4-Chloro-N,N′-dimethylbenzamide-2-yl 3-deoxy...)
Show SMILES CN(C)C(=O)c1ccc(Cl)cc1S[C@H]1OC(CO)[C@H](O)[C@@H](C1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C20H22ClN5O6S2/c1-25(2)18(30)10-4-3-9(21)5-14(10)34-19-17(29)15(16(28)13(7-27)32-19)26-6-11(23-24-26)12-8-33-20(31)22-12/h3-6,8,13,15-17,19,27-29H,7H2,1-2H3,(H,22,31)/t13?,15-,16-,17?,19+/m0/s1
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n/an/an/a 44n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-3


(Homo sapiens (Human))
BDBM508732
PNG
(5-Chloro-2-cyano-pyridine-3-yl 3-[4-(4-chlorothiaz...)
Show SMILES OCC1O[C@H](Sc2cc(Cl)cnc2C#N)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1nc(Cl)cs1
Show InChI InChI=1S/C17H14Cl2N6O4S2/c18-7-1-11(8(2-20)21-3-7)31-17-15(28)13(14(27)10(5-26)29-17)25-4-9(23-24-25)16-22-12(19)6-30-16/h1,3-4,6,10,13-15,17,26-28H,5H2/t10?,13-,14-,15?,17+/m0/s1
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n/an/an/a 220n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM508741
PNG
(5-Chloro-6-trifluoromethyl-pyridin-3-yl 3-deoxy-3-...)
Show SMILES OCC1O[C@H](Sc2cnc(c(Cl)c2)C(F)(F)F)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C17H15ClF3N5O5S2/c18-7-1-6(2-22-14(7)17(19,20)21)33-15-13(29)11(12(28)10(4-27)31-15)26-3-8(24-25-26)9-5-32-16(30)23-9/h1-3,5,10-13,15,27-29H,4H2,(H,23,30)/t10?,11-,12-,13?,15+/m0/s1
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n/an/an/a 28n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-3


(Homo sapiens (Human))
BDBM508749
PNG
(2-carboxy-5-chloropyridyl 3-deoxy-3-[4-(2-hydroxyt...)
Show SMILES OCC1O[C@H](Sc2cc(Cl)cnc2C(O)=O)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C17H16ClN5O7S2/c18-6-1-10(11(15(27)28)19-2-6)32-16-14(26)12(13(25)9(4-24)30-16)23-3-7(21-22-23)8-5-31-17(29)20-8/h1-3,5,9,12-14,16,24-26H,4H2,(H,20,29)(H,27,28)/t9?,12-,13-,14?,16+/m0/s1
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n/an/an/a 5.70E+3n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM508750
PNG
(5-Bromo-6-trifluoromethyl-pyridine-3-yl 3-deoxy-3-...)
Show SMILES OCC1O[C@H](Sc2cnc(c(Br)c2)C(F)(F)F)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1nc(Cl)c(Cl)s1
Show InChI InChI=1S/C17H13BrCl2F3N5O4S2/c18-6-1-5(2-24-12(6)17(21,22)23)33-16-11(31)9(10(30)8(4-29)32-16)28-3-7(26-27-28)15-25-13(19)14(20)34-15/h1-3,8-11,16,29-31H,4H2/t8?,9-,10-,11?,16+/m0/s1
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n/an/an/a 390n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM508728
PNG
(5-Bromo-6-trifluoromethyl-pyridine-3-yl 3-[4-(4-ch...)
Show SMILES OCC1O[C@H](Sc2cnc(c(Br)c2)C(F)(F)F)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1nc(Cl)cs1
Show InChI InChI=1S/C17H14BrClF3N5O4S2/c18-7-1-6(2-23-14(7)17(20,21)22)33-16-13(30)11(12(29)9(4-28)31-16)27-3-8(25-26-27)15-24-10(19)5-32-15/h1-3,5,9,11-13,16,28-30H,4H2/t9?,11-,12-,13?,16+/m0/s1
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n/an/an/a 110n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM508729
PNG
(5-Bromo-6-trifluoromethyl-pyridine-3-yl 3-[4-(4-br...)
Show SMILES OCC1O[C@H](Sc2cnc(c(Br)c2)C(F)(F)F)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1nc(Br)cs1
Show InChI InChI=1S/C17H14Br2F3N5O4S2/c18-7-1-6(2-23-14(7)17(20,21)22)33-16-13(30)11(12(29)9(4-28)31-16)27-3-8(25-26-27)15-24-10(19)5-32-15/h1-3,5,9,11-13,16,28-30H,4H2/t9?,11-,12-,13?,16+/m0/s1
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n/an/an/a 160n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-3


(Homo sapiens (Human))
BDBM508734
PNG
(3,4-Dichlorophenyl 3-[4-(2-chlorothiazol-4-yl)-1H-...)
Show SMILES OCC1O[C@H](Sc2ccc(Cl)c(Cl)c2)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(Cl)n1
Show InChI InChI=1S/C17H15Cl3N4O4S2/c18-8-2-1-7(3-9(8)19)30-16-15(27)13(14(26)12(5-25)28-16)24-4-10(22-23-24)11-6-29-17(20)21-11/h1-4,6,12-16,25-27H,5H2/t12?,13-,14-,15?,16+/m0/s1
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n/an/an/a 1.40E+3n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-3


(Homo sapiens (Human))
BDBM508735
PNG
(3,4-Dichlorophenyl 3-deoxy-3-[4-(4-hydroxythiazol-...)
Show SMILES OCC1O[C@H](Sc2ccc(Cl)c(Cl)c2)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1nc(O)cs1
Show InChI InChI=1S/C17H16Cl2N4O5S2/c18-8-2-1-7(3-9(8)19)30-17-15(27)13(14(26)11(5-24)28-17)23-4-10(21-22-23)16-20-12(25)6-29-16/h1-4,6,11,13-15,17,24-27H,5H2/t11?,13-,14-,15?,17+/m0/s1
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n/an/an/a 1.70E+3n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-3


(Homo sapiens (Human))
BDBM508740
PNG
(5-Chloro-2-cyano-3-pyridyl 3-deoxy-3-[4-(2-hydroxy...)
Show SMILES OCC1O[C@H](Sc2cc(Cl)cnc2C#N)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C17H15ClN6O5S2/c18-7-1-12(8(2-19)20-3-7)31-16-15(27)13(14(26)11(5-25)29-16)24-4-9(22-23-24)10-6-30-17(28)21-10/h1,3-4,6,11,13-16,25-27H,5H2,(H,21,28)/t11?,13-,14-,15?,16+/m0/s1
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n/an/an/a 2.20E+3n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-3


(Homo sapiens (Human))
BDBM508741
PNG
(5-Chloro-6-trifluoromethyl-pyridin-3-yl 3-deoxy-3-...)
Show SMILES OCC1O[C@H](Sc2cnc(c(Cl)c2)C(F)(F)F)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C17H15ClF3N5O5S2/c18-7-1-6(2-22-14(7)17(19,20)21)33-15-13(29)11(12(28)10(4-27)31-15)26-3-8(24-25-26)9-5-32-16(30)23-9/h1-3,5,10-13,15,27-29H,4H2,(H,23,30)/t10?,11-,12-,13?,15+/m0/s1
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n/an/an/a 2.80E+3n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM508744
PNG
(3,5-dibromo-4-fluorophenyl 3-deoxy-3-[4-(2-hydroxy...)
Show SMILES OCC1O[C@H](Sc2cc(Br)c(F)c(Br)c2)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C17H15Br2FN4O5S2/c18-7-1-6(2-8(19)12(7)20)31-16-15(27)13(14(26)11(4-25)29-16)24-3-9(22-23-24)10-5-30-17(28)21-10/h1-3,5,11,13-16,25-27H,4H2,(H,21,28)/t11?,13-,14-,15?,16+/m0/s1
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n/an/an/a 50n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-3


(Homo sapiens (Human))
BDBM508752
PNG
(4-Chloro-N,N′-dimethylbenzamide-2-yl 3-deoxy...)
Show SMILES CN(C)C(=O)c1ccc(Cl)cc1S[C@H]1OC(CO)[C@H](O)[C@@H](C1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C20H22ClN5O6S2/c1-25(2)18(30)10-4-3-9(21)5-14(10)34-19-17(29)15(16(28)13(7-27)32-19)26-6-11(23-24-26)12-8-33-20(31)22-12/h3-6,8,13,15-17,19,27-29H,7H2,1-2H3,(H,22,31)/t13?,15-,16-,17?,19+/m0/s1
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n/an/an/a 2.10E+3n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM508735
PNG
(3,4-Dichlorophenyl 3-deoxy-3-[4-(4-hydroxythiazol-...)
Show SMILES OCC1O[C@H](Sc2ccc(Cl)c(Cl)c2)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1nc(O)cs1
Show InChI InChI=1S/C17H16Cl2N4O5S2/c18-8-2-1-7(3-9(8)19)30-17-15(27)13(14(26)11(5-24)28-17)23-4-10(21-22-23)16-20-12(25)6-29-16/h1-4,6,11,13-15,17,24-27H,5H2/t11?,13-,14-,15?,17+/m0/s1
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GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-3


(Homo sapiens (Human))
BDBM508744
PNG
(3,5-dibromo-4-fluorophenyl 3-deoxy-3-[4-(2-hydroxy...)
Show SMILES OCC1O[C@H](Sc2cc(Br)c(F)c(Br)c2)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C17H15Br2FN4O5S2/c18-7-1-6(2-8(19)12(7)20)31-16-15(27)13(14(26)11(4-25)29-16)24-3-9(22-23-24)10-5-30-17(28)21-10/h1-3,5,11,13-16,25-27H,4H2,(H,21,28)/t11?,13-,14-,15?,16+/m0/s1
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n/an/an/a 4.60E+3n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-3


(Homo sapiens (Human))
BDBM508753
PNG
(5-Chloro-N,N′-dimethyl-picolinamide-3-yl 3-d...)
Show SMILES CN(C)C(=O)c1ncc(Cl)cc1S[C@H]1OC(CO)[C@H](O)[C@@H](C1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C19H21ClN6O6S2/c1-25(2)17(30)13-12(3-8(20)4-21-13)34-18-16(29)14(15(28)11(6-27)32-18)26-5-9(23-24-26)10-7-33-19(31)22-10/h3-5,7,11,14-16,18,27-29H,6H2,1-2H3,(H,22,31)/t11?,14-,15-,16?,18+/m0/s1
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n/an/an/a 1.70E+3n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-3


(Homo sapiens (Human))
BDBM508733
PNG
(5-Bromo-6-cyano-3-pyridyl 3-[4-(4-chlorothiazol-2-...)
Show SMILES OCC1O[C@H](Sc2cnc(C#N)c(Br)c2)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1nc(Cl)cs1
Show InChI InChI=1S/C17H14BrClN6O4S2/c18-8-1-7(3-21-9(8)2-20)31-17-15(28)13(14(27)11(5-26)29-17)25-4-10(23-24-25)16-22-12(19)6-30-16/h1,3-4,6,11,13-15,17,26-28H,5H2/t11?,13-,14-,15?,17+/m0/s1
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n/an/an/a 250n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM508734
PNG
(3,4-Dichlorophenyl 3-[4-(2-chlorothiazol-4-yl)-1H-...)
Show SMILES OCC1O[C@H](Sc2ccc(Cl)c(Cl)c2)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(Cl)n1
Show InChI InChI=1S/C17H15Cl3N4O4S2/c18-8-2-1-7(3-9(8)19)30-16-15(27)13(14(26)12(5-25)28-16)24-4-10(22-23-24)11-6-29-17(20)21-11/h1-4,6,12-16,25-27H,5H2/t12?,13-,14-,15?,16+/m0/s1
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n/an/an/a 490n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-3


(Homo sapiens (Human))
BDBM508736
PNG
(3,4-Dichlorophenyl 3-deoxy-3-[4-(2-hydroxythiazol-...)
Show SMILES OCC1O[C@H](Sc2ccc(Cl)c(Cl)c2)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C17H16Cl2N4O5S2/c18-8-2-1-7(3-9(8)19)30-16-15(26)13(14(25)12(5-24)28-16)23-4-10(21-22-23)11-6-29-17(27)20-11/h1-4,6,12-16,24-26H,5H2,(H,20,27)/t12?,13-,14-,15?,16+/m0/s1
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n/an/an/a 8.60E+3n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-3


(Homo sapiens (Human))
BDBM508737
PNG
(5-Chloro-6-cyano-pyridine-3-yl 3-deoxy-3-[4-(2-hyd...)
Show SMILES OCC1O[C@H](Sc2cnc(Cl)c(Cl)c2)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C16H15Cl2N5O5S2/c17-7-1-6(2-19-14(7)18)30-15-13(26)11(12(25)10(4-24)28-15)23-3-8(21-22-23)9-5-29-16(27)20-9/h1-3,5,10-13,15,24-26H,4H2,(H,20,27)/t10?,11-,12-,13?,15+/m0/s1
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n/an/an/a 8.00E+3n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-3


(Homo sapiens (Human))
BDBM508742
PNG
(3,5-Dichloro-4-fluoro-phenyl 3-deoxy-3-[4-(2-hydro...)
Show SMILES OCC1O[C@H](Sc2cc(Cl)c(F)c(Cl)c2)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C17H15Cl2FN4O5S2/c18-7-1-6(2-8(19)12(7)20)31-16-15(27)13(14(26)11(4-25)29-16)24-3-9(22-23-24)10-5-30-17(28)21-10/h1-3,5,11,13-16,25-27H,4H2,(H,21,28)/t11?,13-,14-,15?,16+/m0/s1
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n/an/an/a 9.70E+3n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM508746
PNG
(5-Bromo-6-trifluoromethyl-3-pyridyl 3-deoxy-3-[4-(...)
Show SMILES OCC1O[C@H](Sc2cnc(c(Br)c2)C(F)(F)F)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C17H15BrF3N5O5S2/c18-7-1-6(2-22-14(7)17(19,20)21)33-15-13(29)11(12(28)10(4-27)31-15)26-3-8(24-25-26)9-5-32-16(30)23-9/h1-3,5,10-13,15,27-29H,4H2,(H,23,30)/t10?,11-,12-,13?,15+/m0/s1
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n/an/an/a 32n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM508749
PNG
(2-carboxy-5-chloropyridyl 3-deoxy-3-[4-(2-hydroxyt...)
Show SMILES OCC1O[C@H](Sc2cc(Cl)cnc2C(O)=O)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C17H16ClN5O7S2/c18-6-1-10(11(15(27)28)19-2-6)32-16-14(26)12(13(25)9(4-24)30-16)23-3-7(21-22-23)8-5-31-17(29)20-8/h1-3,5,9,12-14,16,24-26H,4H2,(H,20,29)(H,27,28)/t9?,12-,13-,14?,16+/m0/s1
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n/an/an/a 46n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-3


(Homo sapiens (Human))
BDBM508728
PNG
(5-Bromo-6-trifluoromethyl-pyridine-3-yl 3-[4-(4-ch...)
Show SMILES OCC1O[C@H](Sc2cnc(c(Br)c2)C(F)(F)F)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1nc(Cl)cs1
Show InChI InChI=1S/C17H14BrClF3N5O4S2/c18-7-1-6(2-23-14(7)17(20,21)22)33-16-13(30)11(12(29)9(4-28)31-16)27-3-8(25-26-27)15-24-10(19)5-32-15/h1-3,5,9,11-13,16,28-30H,4H2/t9?,11-,12-,13?,16+/m0/s1
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GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM508736
PNG
(3,4-Dichlorophenyl 3-deoxy-3-[4-(2-hydroxythiazol-...)
Show SMILES OCC1O[C@H](Sc2ccc(Cl)c(Cl)c2)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C17H16Cl2N4O5S2/c18-8-2-1-7(3-9(8)19)30-16-15(26)13(14(25)12(5-24)28-16)23-4-10(21-22-23)11-6-29-17(27)20-11/h1-4,6,12-16,24-26H,5H2,(H,20,27)/t12?,13-,14-,15?,16+/m0/s1
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n/an/an/a 58n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-1


(Homo sapiens (Human))
BDBM508742
PNG
(3,5-Dichloro-4-fluoro-phenyl 3-deoxy-3-[4-(2-hydro...)
Show SMILES OCC1O[C@H](Sc2cc(Cl)c(F)c(Cl)c2)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1csc(O)n1
Show InChI InChI=1S/C17H15Cl2FN4O5S2/c18-7-1-6(2-8(19)12(7)20)31-16-15(27)13(14(26)11(4-25)29-16)24-3-9(22-23-24)10-5-30-17(28)21-10/h1-3,5,11,13-16,25-27H,4H2,(H,21,28)/t11?,13-,14-,15?,16+/m0/s1
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n/an/an/a 27n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
Galectin-3


(Homo sapiens (Human))
BDBM508731
PNG
(5-Bromo-2-cyano-pyridine-3-yl 3-[4-(4-chlorothiazo...)
Show SMILES OCC1O[C@H](Sc2cc(Br)cnc2C#N)C(O)[C@H]([C@H]1O)n1cc(nn1)-c1nc(Cl)cs1
Show InChI InChI=1S/C17H14BrClN6O4S2/c18-7-1-11(8(2-20)21-3-7)31-17-15(28)13(14(27)10(5-26)29-17)25-4-9(23-24-25)16-22-12(19)6-30-16/h1,3-4,6,10,13-15,17,26-28H,5H2/t10?,13-,14-,15?,17+/m0/s1
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n/an/an/a 200n/an/an/an/an/a



GALECTO BIOTECH AB

US Patent


Assay Description
The affinity of Example 1-33 for galectins were determined by a fluorescence anisotropy assay where the compound was used as an inhibitor of the inte...


US Patent US11046725 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%