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Patent code US11065231

Compile Data Set for Download or QSAR
Found 55 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504430
PNG
((2S,4R)-1-((S)-2-(tert-butyl)- 17-(4-((1-((1SR,4SR...)
Show SMILES Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCN2CCN(Cc3ccc4n(C5CC[C@H](CO)CC5)c(NC(=O)c5cccc(c5)C(F)(F)F)nc4c3)CC2)C(C)(C)C)cc1
Show InChI InChI=1S/C59H78F3N9O10S/c1-39-52(82-38-64-39)43-13-8-40(9-14-43)33-63-55(76)50-32-47(73)35-70(50)56(77)53(58(2,3)4)66-51(74)37-81-29-28-80-27-26-79-25-24-78-23-22-68-18-20-69(21-19-68)34-42-12-17-49-48(30-42)65-57(71(49)46-15-10-41(36-72)11-16-46)67-54(75)44-6-5-7-45(31-44)59(60,61)62/h5-9,12-14,17,30-31,38,41,46-47,50,53,72-73H,10-11,15-16,18-29,32-37H2,1-4H3,(H,63,76)(H,66,74)(H,65,67,75)/t41-,46?,47-,50+,53-/m1/s1
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n/an/a<30n/an/an/an/an/an/a



ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504485
PNG
(N-(2-(1-(2-(2-(2-((2-(2,6- dioxopiperidin-3-yl)-1-...)
Show SMILES COc1cc2nn(cc2cc1NC(=O)c1cccc(n1)C(F)(F)F)C1CCN(CCOCCOCCOc2ccc3C(=O)N(Cc3c2)C2CCC(=O)NC2=O)CC1
Show InChI InChI=1S/C39H42F3N7O8/c1-54-33-21-30-25(20-31(33)44-36(51)29-3-2-4-34(43-29)39(40,41)42)23-49(46-30)26-9-11-47(12-10-26)13-14-55-15-16-56-17-18-57-27-5-6-28-24(19-27)22-48(38(28)53)32-7-8-35(50)45-37(32)52/h2-6,19-21,23,26,32H,7-18,22H2,1H3,(H,44,51)(H,45,50,52)
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n/an/a<30n/an/an/an/an/an/a



ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50502736
PNG
(CHEMBL4472363 | US11065231, Example 9)
Show SMILES OC[C@H]1CC[C@H](CC1)n1c(NC(=O)c2cccc(c2)C(F)(F)F)nc2cc(CN3CCN(CC4CCN(CC4)c4ccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c5c4)CC3)ccc12
Show InChI InChI=1S/C46H51F3N8O6/c47-46(48,49)32-3-1-2-31(23-32)41(60)52-45-50-37-22-30(6-11-38(37)56(45)33-7-4-29(27-58)5-8-33)26-54-20-18-53(19-21-54)25-28-14-16-55(17-15-28)34-9-10-35-36(24-34)44(63)57(43(35)62)39-12-13-40(59)51-42(39)61/h1-3,6,9-11,22-24,28-29,33,39,58H,4-5,7-8,12-21,25-27H2,(H,50,52,60)(H,51,59,61)/t29-,33+,39?
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n/an/a<30n/an/an/an/an/an/a



ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504488
PNG
(N-(2-(1-(2-(2-(2-(2-((2-(2,6- dioxopiperidin-3-yl)...)
Show SMILES COc1cc2nn(cc2cc1NC(=O)c1cccc(n1)C(F)(F)F)C1CCN(CCOCCOCCOCCNc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)CC1
Show InChI InChI=1S/C41H45F3N8O9/c1-58-33-23-30-25(22-31(33)47-37(54)29-6-3-7-34(46-29)41(42,43)44)24-51(49-30)26-10-13-50(14-11-26)15-17-60-19-21-61-20-18-59-16-12-45-28-5-2-4-27-36(28)40(57)52(39(27)56)32-8-9-35(53)48-38(32)55/h2-7,22-24,26,32,45H,8-21H2,1H3,(H,47,54)(H,48,53,55)
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n/an/a<30n/an/an/an/an/an/a



ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504422
PNG
(N-(5-((4-(2-(2-((2-(2,6- dioxopiperidin-3-yl)-1- o...)
Show SMILES OC[C@H]1CC[C@H](CC1)n1c(NC(=O)c2cccc(c2)C(F)(F)F)nc2cc(CN3CCN(CCOCCOc4ccc5C(=O)N(Cc5c4)C4CCC(=O)NC4=O)CC3)ccc12
Show InChI InChI=1S/C44H50F3N7O7/c45-44(46,47)32-3-1-2-30(23-32)40(57)50-43-48-36-22-29(6-11-37(36)54(43)33-7-4-28(27-55)5-8-33)25-52-16-14-51(15-17-52)18-19-60-20-21-61-34-9-10-35-31(24-34)26-53(42(35)59)38-12-13-39(56)49-41(38)58/h1-3,6,9-11,22-24,28,33,38,55H,4-5,7-8,12-21,25-27H2,(H,48,50,57)(H,49,56,58)/t28-,33+,38?
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n/an/a<30n/an/an/an/an/an/a



ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50502737
PNG
(CHEMBL4441283 | US11065231, Example 58)
Show SMILES COc1cc2nn(cc2cc1NC(=O)c1cccc(n1)C(F)(F)F)C1CCN(CCOCCOc2ccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c3c2)CC1
Show InChI InChI=1S/C37H36F3N7O8/c1-53-30-19-27-21(17-28(30)42-33(49)26-3-2-4-31(41-26)37(38,39)40)20-46(44-27)22-9-11-45(12-10-22)13-14-54-15-16-55-23-5-6-24-25(18-23)36(52)47(35(24)51)29-7-8-32(48)43-34(29)50/h2-6,17-20,22,29H,7-16H2,1H3,(H,42,49)(H,43,48,50)
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n/an/a<30n/an/an/an/an/an/a



ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504486
PNG
(N-(2-(1-(2-(2-(2-((2-(2,6- dioxopiperidin-3-yl)-1,...)
Show SMILES COc1cc2nn(cc2cc1NC(=O)c1cccc(n1)C(F)(F)F)C1CCN(CCOCCOCCNc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)CC1
Show InChI InChI=1S/C39H41F3N8O8/c1-56-31-21-28-23(20-29(31)45-35(52)27-6-3-7-32(44-27)39(40,41)42)22-49(47-28)24-10-13-48(14-11-24)15-17-58-19-18-57-16-12-43-26-5-2-4-25-34(26)38(55)50(37(25)54)30-8-9-33(51)46-36(30)53/h2-7,20-22,24,30,43H,8-19H2,1H3,(H,45,52)(H,46,51,53)
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n/an/a<30n/an/an/an/an/an/a



ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504487
PNG
(N-(2-(1-((1-(2-((2-(2,6- dioxopiperidin-3-yl)-1,3-...)
Show SMILES COc1cc2nn(cc2cc1NC(=O)c1cccc(n1)C(F)(F)F)C1CCN(CC2CCN(CCOc3ccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c4c3)CC2)CC1
Show InChI InChI=1S/C41H43F3N8O7/c1-58-34-21-31-25(19-32(34)46-37(54)30-3-2-4-35(45-30)41(42,43)44)23-51(48-31)26-11-15-50(16-12-26)22-24-9-13-49(14-10-24)17-18-59-27-5-6-28-29(20-27)40(57)52(39(28)56)33-7-8-36(53)47-38(33)55/h2-6,19-21,23-24,26,33H,7-18,22H2,1H3,(H,46,54)(H,47,53,55)
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504490
PNG
(N-(5-((4-((4-((2-(2,6- dioxopiperidin-3-yl)-1,3- d...)
Show SMILES OC[C@H]1CCC(CC1)n1c(NC(=O)c2cccc(c2)C(F)(F)F)nc2cc(CN3CCN(CC4CCC(CC4)Oc4ccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c5c4)CC3)ccc12
Show InChI InChI=1S/C47H52F3N7O7/c48-47(49,50)32-3-1-2-31(23-32)42(60)53-46-51-38-22-30(8-15-39(38)56(46)33-9-4-29(27-58)5-10-33)26-55-20-18-54(19-21-55)25-28-6-11-34(12-7-28)64-35-13-14-36-37(24-35)45(63)57(44(36)62)40-16-17-41(59)52-43(40)61/h1-3,8,13-15,22-24,28-29,33-34,40,58H,4-7,9-12,16-21,25-27H2,(H,51,53,60)(H,52,59,61)/t28?,29-,33?,34?,40?
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504418
PNG
(N-(5-((4-(2-(2-((2-(2,6- dioxopiperidin-3-yl)-1,3-...)
Show SMILES OC[C@H]1CCC(CC1)n1c(NC(=O)c2cccc(c2)C(F)(F)F)nc2cc(CN3CCN(CCOCCOc4ccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c5c4)CC3)ccc12
Show InChI InChI=1S/C44H48F3N7O8/c45-44(46,47)30-3-1-2-29(23-30)39(57)50-43-48-35-22-28(6-11-36(35)53(43)31-7-4-27(26-55)5-8-31)25-52-16-14-51(15-17-52)18-19-61-20-21-62-32-9-10-33-34(24-32)42(60)54(41(33)59)37-12-13-38(56)49-40(37)58/h1-3,6,9-11,22-24,27,31,37,55H,4-5,7-8,12-21,25-26H2,(H,48,50,57)(H,49,56,58)/t27-,31?,37?
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n/an/a<30n/an/an/an/an/an/a



ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504421
PNG
(N-(5-((4-(14-((2-(2,6- dioxopiperidin-3-yl)-1,3- d...)
Show SMILES OC[C@H]1CC[C@H](CC1)n1c(NC(=O)c2cccc(c2)C(F)(F)F)nc2cc(CN3CCN(CCOCCOCCOCCOCCOc4ccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c5c4)CC3)ccc12
Show InChI InChI=1S/C50H60F3N7O11/c51-50(52,53)36-3-1-2-35(29-36)45(63)56-49-54-41-28-34(6-11-42(41)59(49)37-7-4-33(32-61)5-8-37)31-58-16-14-57(15-17-58)18-19-67-20-21-68-22-23-69-24-25-70-26-27-71-38-9-10-39-40(30-38)48(66)60(47(39)65)43-12-13-44(62)55-46(43)64/h1-3,6,9-11,28-30,33,37,43,61H,4-5,7-8,12-27,31-32H2,(H,54,56,63)(H,55,62,64)/t33-,37+,43?
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504489
PNG
(N-(5-((4-(2-(2-(2-((2-(2,6- dioxopiperidin-3-yl)-1...)
Show SMILES OC[C@H]1CCC(CC1)n1c(NC(=O)c2cccc(c2)C(F)(F)F)nc2cc(CN3CCN(CCOCCOCCNc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)ccc12
Show InChI InChI=1S/C46H53F3N8O8/c47-46(48,49)32-4-1-3-31(26-32)41(60)53-45-51-36-25-30(9-12-37(36)56(45)33-10-7-29(28-58)8-11-33)27-55-18-16-54(17-19-55)20-22-65-24-23-64-21-15-50-35-6-2-5-34-40(35)44(63)57(43(34)62)38-13-14-39(59)52-42(38)61/h1-6,9,12,25-26,29,33,38,50,58H,7-8,10-11,13-24,27-28H2,(H,51,53,60)(H,52,59,61)/t29-,33?,38?
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504425
PNG
(N-(5-((4-((1-(2-((2-(2,6- dioxopiperidin-3-yl)-1,3...)
Show SMILES OC[C@H]1CCC(CC1)n1c(NC(=O)c2cccc(c2)C(F)(F)F)nc2cc(CN3CCN(CC4CCN(CCOc5ccc6C(=O)N(C7CCC(=O)NC7=O)C(=O)c6c5)CC4)CC3)ccc12
Show InChI InChI=1S/C48H55F3N8O7/c49-48(50,51)34-3-1-2-33(25-34)43(62)54-47-52-39-24-32(6-11-40(39)58(47)35-7-4-31(29-60)5-8-35)28-57-20-18-56(19-21-57)27-30-14-16-55(17-15-30)22-23-66-36-9-10-37-38(26-36)46(65)59(45(37)64)41-12-13-42(61)53-44(41)63/h1-3,6,9-11,24-26,30-31,35,41,60H,4-5,7-8,12-23,27-29H2,(H,52,54,62)(H,53,61,63)/t31-,35?,41?
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504417
PNG
(N-(5-((4-(2-((2-(2,6- dioxopiperidin-3-yl)-1,3- di...)
Show SMILES OC[C@H]1CCC(CC1)n1c(NC(=O)c2cccc(c2)C(F)(F)F)nc2cc(CN3CCN(CCOc4ccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c5c4)CC3)ccc12
Show InChI InChI=1S/C42H44F3N7O7/c43-42(44,45)28-3-1-2-27(21-28)37(55)48-41-46-33-20-26(6-11-34(33)51(41)29-7-4-25(24-53)5-8-29)23-50-16-14-49(15-17-50)18-19-59-30-9-10-31-32(22-30)40(58)52(39(31)57)35-12-13-36(54)47-38(35)56/h1-3,6,9-11,20-22,25,29,35,53H,4-5,7-8,12-19,23-24H2,(H,46,48,55)(H,47,54,56)/t25-,29?,35?
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504420
PNG
(N-(5-((4-(2-(2-(2-(2-((2-(2,6- dioxopiperidin-3-yl...)
Show SMILES OC[C@H]1CC[C@H](CC1)n1c(NC(=O)c2cccc(c2)C(F)(F)F)nc2cc(CN3CCN(CCOCCOCCOCCOc4ccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c5c4)CC3)ccc12
Show InChI InChI=1S/C48H56F3N7O10/c49-48(50,51)34-3-1-2-33(27-34)43(61)54-47-52-39-26-32(6-11-40(39)57(47)35-7-4-31(30-59)5-8-35)29-56-16-14-55(15-17-56)18-19-65-20-21-66-22-23-67-24-25-68-36-9-10-37-38(28-36)46(64)58(45(37)63)41-12-13-42(60)53-44(41)62/h1-3,6,9-11,26-28,31,35,41,59H,4-5,7-8,12-25,29-30H2,(H,52,54,61)(H,53,60,62)/t31-,35+,41?
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50502740
PNG
(CHEMBL4592457 | US11065231, Example 60)
Show SMILES COc1cc2nn(cc2cc1NC(=O)c1cccc(n1)C(F)(F)F)C1CCN(CCOCCOc2ccc3C(=O)N(Cc3c2)C2CCC(=O)NC2=O)CC1
Show InChI InChI=1S/C37H38F3N7O7/c1-52-31-19-28-23(18-29(31)42-34(49)27-3-2-4-32(41-27)37(38,39)40)21-47(44-28)24-9-11-45(12-10-24)13-14-53-15-16-54-25-5-6-26-22(17-25)20-46(36(26)51)30-7-8-33(48)43-35(30)50/h2-6,17-19,21,24,30H,7-16,20H2,1H3,(H,42,49)(H,43,48,50)
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n/an/a<30n/an/an/an/an/an/a



ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504483
PNG
(N-(2-(1-(2-(2-(2-((2-(2,6- dioxopiperidin-3-yl)-1,...)
Show SMILES COc1cc2nn(cc2cc1NC(=O)c1cccc(n1)C(F)(F)F)C1CCN(CCOCCOCCOc2ccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c3c2)CC1
Show InChI InChI=1S/C39H40F3N7O9/c1-55-32-21-29-23(19-30(32)44-35(51)28-3-2-4-33(43-28)39(40,41)42)22-48(46-29)24-9-11-47(12-10-24)13-14-56-15-16-57-17-18-58-25-5-6-26-27(20-25)38(54)49(37(26)53)31-7-8-34(50)45-36(31)52/h2-6,19-22,24,31H,7-18H2,1H3,(H,44,51)(H,45,50,52)
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50502739
PNG
(CHEMBL4447648 | US11065231, Example 3)
Show SMILES OC[C@H]1CC[C@H](CC1)n1c(NC(=O)c2cccc(c2)C(F)(F)F)nc2cc(CN3CCN(CCOCCOCCOc4ccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c5c4)CC3)ccc12
Show InChI InChI=1S/C46H52F3N7O9/c47-46(48,49)32-3-1-2-31(25-32)41(59)52-45-50-37-24-30(6-11-38(37)55(45)33-7-4-29(28-57)5-8-33)27-54-16-14-53(15-17-54)18-19-63-20-21-64-22-23-65-34-9-10-35-36(26-34)44(62)56(43(35)61)39-12-13-40(58)51-42(39)60/h1-3,6,9-11,24-26,29,33,39,57H,4-5,7-8,12-23,27-28H2,(H,50,52,59)(H,51,58,60)/t29-,33+,39?
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n/an/a<30n/an/an/an/an/an/a



ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504428
PNG
((2S,4R)-4-hydroxy-1-((S)-2- (2-(2-(2-(4-((1-((1SR,...)
Show SMILES Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CC2C(=O)[C@@H](NC(=O)COCCOCCN2CCN(Cc3ccc4n(C5CC[C@H](CO)CC5)c(NC(=O)c5cccc(c5)C(F)(F)F)nc4c3)CC2)C(C)(C)C)cc1
Show InChI InChI=1S/C56H71F3N8O8S/c1-35-50(76-34-61-35)39-13-8-36(9-14-39)30-60-53(73)45-29-43(69)28-44(45)49(71)51(55(2,3)4)63-48(70)33-75-25-24-74-23-22-65-18-20-66(21-19-65)31-38-12-17-47-46(26-38)62-54(67(47)42-15-10-37(32-68)11-16-42)64-52(72)40-6-5-7-41(27-40)56(57,58)59/h5-9,12-14,17,26-27,34,37,42-45,51,68-69H,10-11,15-16,18-25,28-33H2,1-4H3,(H,60,73)(H,63,70)(H,62,64,72)/t37-,42?,43-,44?,45+,51+/m0/s1
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504432
PNG
(N-(3-(4-(2-(2-(2-((2-(2,6- dioxopiperidin-3-yl)-1,...)
Show SMILES Cc1ccc(nc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)N1CCN(CCOCCOCCOc2ccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c3c2)CC1
Show InChI InChI=1S/C39H41N11O8/c1-25-3-7-31(41-23-25)50-32(43-36(52)29-24-42-48-10-2-9-40-35(29)48)22-33(45-50)47-13-11-46(12-14-47)15-16-56-17-18-57-19-20-58-26-4-5-27-28(21-26)39(55)49(38(27)54)30-6-8-34(51)44-37(30)53/h2-5,7,9-10,21-24,30H,6,8,11-20H2,1H3,(H,43,52)(H,44,51,53)
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504423
PNG
(N-(5-((4-(2-(2-((2-(2,6- dioxopiperidin-3-yl)-1,3-...)
Show SMILES C[C@H]1CCC(CC1)n1c(NC(=O)c2cccc(c2)C(F)(F)F)nc2cc(CN3CCN(CCOCCOc4ccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c5c4)CC3)ccc12
Show InChI InChI=1S/C44H48F3N7O7/c1-27-5-8-31(9-6-27)53-36-12-7-28(23-35(36)48-43(53)50-39(56)29-3-2-4-30(24-29)44(45,46)47)26-52-17-15-51(16-18-52)19-20-60-21-22-61-32-10-11-33-34(25-32)42(59)54(41(33)58)37-13-14-38(55)49-40(37)57/h2-4,7,10-12,23-25,27,31,37H,5-6,8-9,13-22,26H2,1H3,(H,48,50,56)(H,49,55,57)/t27-,31?,37?
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504435
PNG
(N-(3-(4-((S)-16-((2S,4R)-4- hydroxy-2-((4-(4- meth...)
Show SMILES Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCN2CCN(CC2)c2cc(NC(=O)c3cnn4cccnc34)n(n2)-c2ccc(C)cn2)C(C)(C)C)cc1
Show InChI InChI=1S/C52H67N13O9S/c1-35-7-12-42(54-29-35)65-43(58-49(68)40-31-57-64-14-6-13-53-48(40)64)28-44(60-65)62-17-15-61(16-18-62)19-20-71-21-22-72-23-24-73-25-26-74-33-45(67)59-47(52(3,4)5)51(70)63-32-39(66)27-41(63)50(69)55-30-37-8-10-38(11-9-37)46-36(2)56-34-75-46/h6-14,28-29,31,34,39,41,47,66H,15-27,30,32-33H2,1-5H3,(H,55,69)(H,58,68)(H,59,67)/t39-,41+,47-/m1/s1
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504437
PNG
(4-((1r,4r)-4-(4-(2-((2-(2,6- dioxopiperidin-3-yl)-...)
Show SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)c2cc(OCCN3CCN(CC3)[C@H]3CC[C@@H](CC3)Nc3ncnc4ccc(cc34)C#N)ccc12
Show InChI InChI=1S/C34H36N8O5/c35-19-21-1-8-28-27(17-21)31(37-20-36-28)38-22-2-4-23(5-3-22)41-13-11-40(12-14-41)15-16-47-24-6-7-25-26(18-24)34(46)42(33(25)45)29-9-10-30(43)39-32(29)44/h1,6-8,17-18,20,22-23,29H,2-5,9-16H2,(H,36,37,38)(H,39,43,44)/t22-,23-,29?
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n/an/a 650n/an/an/an/an/an/a



ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504426
PNG
((2S,4R)-4-hydroxy-1-((S)-2- (2-(2-(4-((1-((1SR,4SR...)
Show SMILES Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCN2CCN(Cc3ccc4n(C5CC[C@H](CO)CC5)c(NC(=O)c5cccc(c5)C(F)(F)F)nc4c3)CC2)C(C)(C)C)cc1
Show InChI InChI=1S/C53H66F3N9O7S/c1-33-46(73-32-58-33)37-13-8-34(9-14-37)27-57-49(70)44-26-41(67)29-64(44)50(71)47(52(2,3)4)60-45(68)31-72-23-22-62-18-20-63(21-19-62)28-36-12-17-43-42(24-36)59-51(65(43)40-15-10-35(30-66)11-16-40)61-48(69)38-6-5-7-39(25-38)53(54,55)56/h5-9,12-14,17,24-25,32,35,40-41,44,47,66-67H,10-11,15-16,18-23,26-31H2,1-4H3,(H,57,70)(H,60,68)(H,59,61,69)/t35-,40?,41-,44+,47-/m1/s1
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504462
PNG
(N-(1-((1s,4s)-4-(13-((2-(2,6- dioxopiperidin-3-yl)...)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)NC1Nc2cc(CN3CCCCC3)ccc2N1[C@@H]1CC[C@H](COCCOCCOCCOCCOc2ccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c3c2)CC1
Show InChI InChI=1S/C49H59F3N6O10/c50-49(51,52)35-6-4-5-34(28-35)44(60)55-48-53-40-27-33(30-56-17-2-1-3-18-56)9-14-41(40)57(48)36-10-7-32(8-11-36)31-67-24-23-65-20-19-64-21-22-66-25-26-68-37-12-13-38-39(29-37)47(63)58(46(38)62)42-15-16-43(59)54-45(42)61/h4-6,9,12-14,27-29,32,36,42,48,53H,1-3,7-8,10-11,15-26,30-31H2,(H,55,60)(H,54,59,61)/t32-,36+,42?,48?
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504429
PNG
((2S,4R)-1-((S)-2-(tert-butyl)- 14-(4-((1-((1SR,4SR...)
Show SMILES Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCN2CCN(Cc3ccc4n(C5CC[C@H](CO)CC5)c(NC(=O)c5cccc(c5)C(F)(F)F)nc4c3)CC2)C(C)(C)C)cc1
Show InChI InChI=1S/C57H74F3N9O9S/c1-37-50(79-36-62-37)41-13-8-38(9-14-41)31-61-53(74)48-30-45(71)33-68(48)54(75)51(56(2,3)4)64-49(72)35-78-27-26-77-25-24-76-23-22-66-18-20-67(21-19-66)32-40-12-17-47-46(28-40)63-55(69(47)44-15-10-39(34-70)11-16-44)65-52(73)42-6-5-7-43(29-42)57(58,59)60/h5-9,12-14,17,28-29,36,39,44-45,48,51,70-71H,10-11,15-16,18-27,30-35H2,1-4H3,(H,61,74)(H,64,72)(H,63,65,73)/t39-,44?,45-,48+,51-/m1/s1
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504434
PNG
(N-(3-(4-((S)-13-((2S,4R)-4- hydroxy-2-((4-(4- meth...)
Show SMILES Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CC2C(=O)[C@@H](NC(=O)COCCOCCOCCN2CCN(CC2)c2cc(NC(=O)c3cnn4cccnc34)n(n2)-c2ccc(C)cn2)C(C)(C)C)cc1
Show InChI InChI=1S/C51H64N12O8S/c1-33-7-12-41(53-28-33)63-42(57-50(68)40-30-56-62-14-6-13-52-48(40)62)27-43(59-63)61-17-15-60(16-18-61)19-20-69-21-22-70-23-24-71-31-44(65)58-47(51(3,4)5)45(66)38-25-37(64)26-39(38)49(67)54-29-35-8-10-36(11-9-35)46-34(2)55-32-72-46/h6-14,27-28,30,32,37-39,47,64H,15-26,29,31H2,1-5H3,(H,54,67)(H,57,68)(H,58,65)/t37-,38?,39+,47+/m0/s1
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504438
PNG
(4-((1r,4r)-4-(4-(2-(2-((2- (2,6-dioxopiperidin-3-y...)
Show SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)c2cc(OCCOCCN3CCN(CC3)[C@H]3CC[C@@H](CC3)Nc3ncnc4ccc(cc34)C#N)ccc12
Show InChI InChI=1S/C36H40N8O6/c37-21-23-1-8-30-29(19-23)33(39-22-38-30)40-24-2-4-25(5-3-24)43-13-11-42(12-14-43)15-16-49-17-18-50-26-6-7-27-28(20-26)36(48)44(35(27)47)31-9-10-32(45)41-34(31)46/h1,6-8,19-20,22,24-25,31H,2-5,9-18H2,(H,38,39,40)(H,41,45,46)/t24-,25-,31?
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504433
PNG
(N-(3-(4-(2-(2-(2-(2-((2-(2,6- dioxopiperidin-3-yl)...)
Show SMILES Cc1ccc(nc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)N1CCN(CCOCCOCCOCCOc2ccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c3c2)CC1
Show InChI InChI=1S/C41H45N11O9/c1-27-3-7-33(43-25-27)52-34(45-38(54)31-26-44-50-10-2-9-42-37(31)50)24-35(47-52)49-13-11-48(12-14-49)15-16-58-17-18-59-19-20-60-21-22-61-28-4-5-29-30(23-28)41(57)51(40(29)56)32-6-8-36(53)46-39(32)55/h2-5,7,9-10,23-26,32H,6,8,11-22H2,1H3,(H,45,54)(H,46,53,55)
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504472
PNG
(N-(1-(3-((2-((2-(2,6- dioxopiperidin-3-yl)-1,3- di...)
Show SMILES CN(CCOc1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1)c1cccc(c1)-n1c(NC(=O)c2cccc(c2)C(F)(F)F)nc2cc(F)ccc12
Show InChI InChI=1S/C37H28F4N6O6/c1-45(14-15-53-25-9-10-26-27(19-25)35(52)47(34(26)51)30-12-13-31(48)43-33(30)50)23-6-3-7-24(18-23)46-29-11-8-22(38)17-28(29)42-36(46)44-32(49)20-4-2-5-21(16-20)37(39,40)41/h2-11,16-19,30H,12-15H2,1H3,(H,42,44,49)(H,43,48,50)
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504465
PNG
(N-(1-((1s,4s)-4-((2-((2-(2,6- dioxopiperidin-3-yl)...)
Show SMILES Fc1ccc2n([C@@H]3CC[C@H](COCCOc4ccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c5c4)CC3)c(NC(=O)c3cccc(c3)C(F)(F)F)nc2c1
Show InChI InChI=1S/C37H33F4N5O7/c38-23-6-11-29-28(17-23)42-36(44-32(48)21-2-1-3-22(16-21)37(39,40)41)45(29)24-7-4-20(5-8-24)19-52-14-15-53-25-9-10-26-27(18-25)35(51)46(34(26)50)30-12-13-31(47)43-33(30)49/h1-3,6,9-11,16-18,20,24,30H,4-5,7-8,12-15,19H2,(H,42,44,48)(H,43,47,49)/t20-,24+,30?
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504463
PNG
(N-(1-((1s,4s)-4-((2-(2-((2- (2,6-dioxopiperidin-3-...)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1nc2cc(CN3CCCCC3)ccc2n1[C@@H]1CC[C@H](COCCOCCOc2ccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c3c2)CC1
Show InChI InChI=1S/C45H49F3N6O8/c46-45(47,48)31-6-4-5-30(24-31)40(56)51-44-49-36-23-29(26-52-17-2-1-3-18-52)9-14-37(36)53(44)32-10-7-28(8-11-32)27-61-20-19-60-21-22-62-33-12-13-34-35(25-33)43(59)54(42(34)58)38-15-16-39(55)50-41(38)57/h4-6,9,12-14,23-25,28,32,38H,1-3,7-8,10-11,15-22,26-27H2,(H,49,51,56)(H,50,55,57)/t28-,32+,38?
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504460
PNG
(4-((1r,4r)-4-(4-((14-((2- (2,6-dioxopiperidin-3-yl...)
Show SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)c2cc(OCCOCCOCCOCCOCCS(=O)(=O)N3CCN(CC3)[C@H]3CC[C@@H](CC3)Nc3ncnc4ccc(cc34)C#N)ccc12
Show InChI InChI=1S/C42H52N8O11S/c43-27-29-1-8-36-35(25-29)39(45-28-44-36)46-30-2-4-31(5-3-30)48-11-13-49(14-12-48)62(55,56)24-23-60-20-19-58-16-15-57-17-18-59-21-22-61-32-6-7-33-34(26-32)42(54)50(41(33)53)37-9-10-38(51)47-40(37)52/h1,6-8,25-26,28,30-31,37H,2-5,9-24H2,(H,44,45,46)(H,47,51,52)/t30-,31-,37?
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504439
PNG
(4-((1r,4r)-4-(4-(2-(2-(2-((2- (2,6-dioxopiperidin-...)
Show SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)c2cc(OCCOCCOCCN3CCN(CC3)[C@H]3CC[C@@H](CC3)Nc3ncnc4ccc(cc34)C#N)ccc12
Show InChI InChI=1S/C38H44N8O7/c39-23-25-1-8-32-31(21-25)35(41-24-40-32)42-26-2-4-27(5-3-26)45-13-11-44(12-14-45)15-16-51-17-18-52-19-20-53-28-6-7-29-30(22-28)38(50)46(37(29)49)33-9-10-34(47)43-36(33)48/h1,6-8,21-22,24,26-27,33H,2-5,9-20H2,(H,40,41,42)(H,43,47,48)/t26-,27-,33?
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504481
PNG
(N-(5-((4-(2-(2-((2-(2,6- dioxopiperidin-3-yl)-1,3-...)
Show SMILES COc1cccc(c1)-n1c(NC(=O)c2cccc(c2)C(F)(F)F)nc2cc(CN3CCN(CCOCCOc4ccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c5c4)CC3)ccc12
Show InChI InChI=1S/C44H42F3N7O8/c1-60-31-7-3-6-30(24-31)53-36-11-8-27(22-35(36)48-43(53)50-39(56)28-4-2-5-29(23-28)44(45,46)47)26-52-16-14-51(15-17-52)18-19-61-20-21-62-32-9-10-33-34(25-32)42(59)54(41(33)58)37-12-13-38(55)49-40(37)57/h2-11,22-25,37H,12-21,26H2,1H3,(H,48,50,56)(H,49,55,57)
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504454
PNG
(4-((1r,4r)-4-(4-((2-(2-((2- (2,6-dioxopiperidin-3-...)
Show SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)c2cc(OCCOCCS(=O)(=O)N3CCN(CC3)[C@H]3CC[C@@H](CC3)Nc3ncnc4ccc(cc34)C#N)ccc12
Show InChI InChI=1S/C36H40N8O8S/c37-21-23-1-8-30-29(19-23)33(39-22-38-30)40-24-2-4-25(5-3-24)42-11-13-43(14-12-42)53(49,50)18-17-51-15-16-52-26-6-7-27-28(20-26)36(48)44(35(27)47)31-9-10-32(45)41-34(31)46/h1,6-8,19-20,22,24-25,31H,2-5,9-18H2,(H,38,39,40)(H,41,45,46)/t24-,25-,31?
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504457
PNG
(4-((1s,4s)-4-(4-((2-(2-(2- ((2-(2,6-dioxopiperidin...)
Show SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)c2cc(OCCOCCOCCS(=O)(=O)N3CCN(CC3)[C@@H]3CC[C@@H](CC3)Nc3ncnc4ccc(cc34)C#N)ccc12
Show InChI InChI=1S/C38H44N8O9S/c39-23-25-1-8-32-31(21-25)35(41-24-40-32)42-26-2-4-27(5-3-26)44-11-13-45(14-12-44)56(51,52)20-19-54-16-15-53-17-18-55-28-6-7-29-30(22-28)38(50)46(37(29)49)33-9-10-34(47)43-36(33)48/h1,6-8,21-22,24,26-27,33H,2-5,9-20H2,(H,40,41,42)(H,43,47,48)/t26-,27+,33?
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504440
PNG
(4-((1r,4r)-4-(4-(2-(2-(2-(2- ((2-(2,6-dioxopiperid...)
Show SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)c2cc(OCCOCCOCCOCCN3CCN(CC3)[C@H]3CC[C@@H](CC3)Nc3ncnc4ccc(cc34)C#N)ccc12
Show InChI InChI=1S/C40H48N8O8/c41-25-27-1-8-34-33(23-27)37(43-26-42-34)44-28-2-4-29(5-3-28)47-13-11-46(12-14-47)15-16-53-17-18-54-19-20-55-21-22-56-30-6-7-31-32(24-30)40(52)48(39(31)51)35-9-10-36(49)45-38(35)50/h1,6-8,23-24,26,28-29,35H,2-5,9-22H2,(H,42,43,44)(H,45,49,50)/t28-,29-,35?
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504477
PNG
(N-(5-((4-(2-(2-(2-((2-(2,6- dioxopiperidin-3-yl)-1...)
Show SMILES COc1cccc(c1)-n1c(NC(=O)c2cccc(c2)C(F)(F)F)nc2cc(CN3CCN(CCOCCOCCOc4ccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c5c4)CC3)ccc12
Show InChI InChI=1S/C46H46F3N7O9/c1-62-33-7-3-6-32(26-33)55-38-11-8-29(24-37(38)50-45(55)52-41(58)30-4-2-5-31(25-30)46(47,48)49)28-54-16-14-53(15-17-54)18-19-63-20-21-64-22-23-65-34-9-10-35-36(27-34)44(61)56(43(35)60)39-12-13-40(57)51-42(39)59/h2-11,24-27,39H,12-23,28H2,1H3,(H,50,52,58)(H,51,57,59)
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504467
PNG
(N-(1-((1s,4s)-4-((2-(2-(2-((2- (2,6-dioxopiperidin...)
Show SMILES Fc1ccc2n([C@@H]3CC[C@H](COCCOCCOCCOc4ccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c5c4)CC3)c(NC(=O)c3cccc(c3)C(F)(F)F)nc2c1
Show InChI InChI=1S/C41H41F4N5O9/c42-27-6-11-33-32(21-27)46-40(48-36(52)25-2-1-3-26(20-25)41(43,44)45)49(33)28-7-4-24(5-8-28)23-58-17-16-56-14-15-57-18-19-59-29-9-10-30-31(22-29)39(55)50(38(30)54)34-12-13-35(51)47-37(34)53/h1-3,6,9-11,20-22,24,28,34H,4-5,7-8,12-19,23H2,(H,46,48,52)(H,47,51,53)/t24-,28+,34?
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504461
PNG
(4-((1s,4s)-4-(4-((14-((2- (2,6-dioxopiperidin-3-yl...)
Show SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)c2cc(OCCOCCOCCOCCOCCS(=O)(=O)N3CCN(CC3)[C@@H]3CC[C@@H](CC3)Nc3ncnc4ccc(cc34)C#N)ccc12
Show InChI InChI=1S/C42H52N8O11S/c43-27-29-1-8-36-35(25-29)39(45-28-44-36)46-30-2-4-31(5-3-30)48-11-13-49(14-12-48)62(55,56)24-23-60-20-19-58-16-15-57-17-18-59-21-22-61-32-6-7-33-34(26-32)42(54)50(41(33)53)37-9-10-38(51)47-40(37)52/h1,6-8,25-26,28,30-31,37H,2-5,9-24H2,(H,44,45,46)(H,47,51,52)/t30-,31+,37?
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504475
PNG
(N-(1-(3-((2-(2-(2-(2-((2-(2,6- dioxopiperidin-3-yl...)
Show SMILES CN(CCOCCOCCOCCOc1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1)c1cccc(c1)-n1c(NC(=O)c2cccc(c2)C(F)(F)F)nc2cc(F)ccc12
Show InChI InChI=1S/C43H40F4N6O9/c1-51(29-6-3-7-30(24-29)52-35-11-8-28(44)23-34(35)48-42(52)50-38(55)26-4-2-5-27(22-26)43(45,46)47)14-15-59-16-17-60-18-19-61-20-21-62-31-9-10-32-33(25-31)41(58)53(40(32)57)36-12-13-37(54)49-39(36)56/h2-11,22-25,36H,12-21H2,1H3,(H,48,50,55)(H,49,54,56)
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504453
PNG
(4-((1r,4r)-4-(4-(14-((2-(2,6- dioxopiperidin-3-yl)...)
Show SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)c2cc(OCCOCCOCCOCCOCCN3CCN(CC3)[C@H]3CC[C@@H](CC3)Nc3ncnc4ccc(cc34)C#N)ccc12
Show InChI InChI=1S/C42H52N8O9/c43-27-29-1-8-36-35(25-29)39(45-28-44-36)46-30-2-4-31(5-3-30)49-13-11-48(12-14-49)15-16-55-17-18-56-19-20-57-21-22-58-23-24-59-32-6-7-33-34(26-32)42(54)50(41(33)53)37-9-10-38(51)47-40(37)52/h1,6-8,25-26,28,30-31,37H,2-5,9-24H2,(H,44,45,46)(H,47,51,52)/t30-,31-,37?
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504478
PNG
(N-(5-((4-(2-((2-(2,6- dioxopiperidin-3-yl)-1,3- di...)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1nc2cc(CN3CCN(CCOc4ccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c5c4)CC3)ccc2n1-c1ccccc1
Show InChI InChI=1S/C41H36F3N7O6/c42-41(43,44)27-6-4-5-26(22-27)36(53)47-40-45-32-21-25(9-12-33(32)50(40)28-7-2-1-3-8-28)24-49-17-15-48(16-18-49)19-20-57-29-10-11-30-31(23-29)39(56)51(38(30)55)34-13-14-35(52)46-37(34)54/h1-12,21-23,34H,13-20,24H2,(H,45,47,53)(H,46,52,54)
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n/an/a>1.00E+3n/an/an/an/an/an/a



ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504476
PNG
(N-(5-((4-(2-(2-(2-((2-(2,6- dioxopiperidin-3-yl)-1...)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1nc2cc(CN3CCN(CCOCCOCCOc4ccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c5c4)CC3)ccc2n1-c1ccccc1
Show InChI InChI=1S/C45H44F3N7O8/c46-45(47,48)31-6-4-5-30(26-31)40(57)51-44-49-36-25-29(9-12-37(36)54(44)32-7-2-1-3-8-32)28-53-17-15-52(16-18-53)19-20-61-21-22-62-23-24-63-33-10-11-34-35(27-33)43(60)55(42(34)59)38-13-14-39(56)50-41(38)58/h1-12,25-27,38H,13-24,28H2,(H,49,51,57)(H,50,56,58)
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504473
PNG
(N-(1-(3-((2-(2-((2-(2,6- dioxopiperidin-3-yl)-1,3-...)
Show SMILES CN(CCOCCOc1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1)c1cccc(c1)-n1c(NC(=O)c2cccc(c2)C(F)(F)F)nc2cc(F)ccc12
Show InChI InChI=1S/C39H32F4N6O7/c1-47(14-15-55-16-17-56-27-9-10-28-29(21-27)37(54)49(36(28)53)32-12-13-33(50)45-35(32)52)25-6-3-7-26(20-25)48-31-11-8-24(40)19-30(31)44-38(48)46-34(51)22-4-2-5-23(18-22)39(41,42)43/h2-11,18-21,32H,12-17H2,1H3,(H,44,46,51)(H,45,50,52)
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504466
PNG
(N-(1-((1s,4s)-4-((2-(2-((2- (2,6-dioxopiperidin-3-...)
Show SMILES Fc1ccc2n([C@@H]3CC[C@H](COCCOCCOc4ccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c5c4)CC3)c(NC(=O)c3cccc(c3)C(F)(F)F)nc2c1
Show InChI InChI=1S/C39H37F4N5O8/c40-25-6-11-31-30(19-25)44-38(46-34(50)23-2-1-3-24(18-23)39(41,42)43)47(31)26-7-4-22(5-8-26)21-55-15-14-54-16-17-56-27-9-10-28-29(20-27)37(53)48(36(28)52)32-12-13-33(49)45-35(32)51/h1-3,6,9-11,18-20,22,26,32H,4-5,7-8,12-17,21H2,(H,44,46,50)(H,45,49,51)/t22-,26+,32?
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504455
PNG
(4-((1s,4s)-4-(4-((2-(2-((2- (2,6-dioxopiperidin-3-...)
Show SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)c2cc(OCCOCCS(=O)(=O)N3CCN(CC3)[C@@H]3CC[C@@H](CC3)Nc3ncnc4ccc(cc34)C#N)ccc12
Show InChI InChI=1S/C36H40N8O8S/c37-21-23-1-8-30-29(19-23)33(39-22-38-30)40-24-2-4-25(5-3-24)42-11-13-43(14-12-42)53(49,50)18-17-51-15-16-52-26-6-7-27-28(20-26)36(48)44(35(27)47)31-9-10-32(45)41-34(31)46/h1,6-8,19-20,22,24-25,31H,2-5,9-18H2,(H,38,39,40)(H,41,45,46)/t24-,25+,31?
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504468
PNG
(N-(1-((1s,4s)-4-(13-((2-(2,6- dioxopiperidin-3-yl)...)
Show SMILES Fc1ccc2n([C@@H]3CC[C@H](COCCOCCOCCOCCOc4ccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c5c4)CC3)c(NC(=O)c3cccc(c3)C(F)(F)F)nc2c1
Show InChI InChI=1S/C43H45F4N5O10/c44-29-6-11-35-34(23-29)48-42(50-38(54)27-2-1-3-28(22-27)43(45,46)47)51(35)30-7-4-26(5-8-30)25-61-19-18-59-15-14-58-16-17-60-20-21-62-31-9-10-32-33(24-31)41(57)52(40(32)56)36-12-13-37(53)49-39(36)55/h1-3,6,9-11,22-24,26,30,36H,4-5,7-8,12-21,25H2,(H,48,50,54)(H,49,53,55)/t26-,30+,36?
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504491
PNG
(US11065231, Example 68)
Show SMILES CN(CCOc1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1)c1cccc(c1)-n1c(NC(=O)c2cccc(c2)C(F)(F)F)nc2cc(CN3CCCCC3)ccc12
Show InChI InChI=1S/C43H40F3N7O6/c1-50(19-20-59-31-12-13-32-33(24-31)41(58)53(40(32)57)36-15-16-37(54)48-39(36)56)29-9-6-10-30(23-29)52-35-14-11-26(25-51-17-3-2-4-18-51)21-34(35)47-42(52)49-38(55)27-7-5-8-28(22-27)43(44,45)46/h5-14,21-24,36H,2-4,15-20,25H2,1H3,(H,47,49,55)(H,48,54,56)
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n/an/a>1.00E+3n/an/an/an/an/an/a



ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504470
PNG
(N-(1-(3-((2-(2-(2-((2-(2,6- dioxopiperidin-3-yl)-1...)
Show SMILES CN(CCOCCOCCOc1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1)c1cccc(c1)-n1c(NC(=O)c2cccc(c2)C(F)(F)F)nc2cc(F)ccc12
Show InChI InChI=1S/C41H36F4N6O8/c1-49(14-15-57-16-17-58-18-19-59-29-9-10-30-31(23-29)39(56)51(38(30)55)34-12-13-35(52)47-37(34)54)27-6-3-7-28(22-27)50-33-11-8-26(42)21-32(33)46-40(50)48-36(53)24-4-2-5-25(20-24)41(43,44)45/h2-11,20-23,34H,12-19H2,1H3,(H,46,48,53)(H,47,52,54)
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504459
PNG
(4-((1s,4s)-4-(4-((2-(2-(2-(2- ((2-(2,6-dioxopiperi...)
Show SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)c2cc(OCCOCCOCCOCCS(=O)(=O)N3CCN(CC3)[C@@H]3CC[C@@H](CC3)Nc3ncnc4ccc(cc34)C#N)ccc12
Show InChI InChI=1S/C40H48N8O10S/c41-25-27-1-8-34-33(23-27)37(43-26-42-34)44-28-2-4-29(5-3-28)46-11-13-47(14-12-46)59(53,54)22-21-57-18-17-55-15-16-56-19-20-58-30-6-7-31-32(24-30)40(52)48(39(31)51)35-9-10-36(49)45-38(35)50/h1,6-8,23-24,26,28-29,35H,2-5,9-22H2,(H,42,43,44)(H,45,49,50)/t28-,29+,35?
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504458
PNG
(4-((1r,4r)-4-(4-((2-(2-(2-(2- ((2-(2,6-dioxopiperi...)
Show SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)c2cc(OCCOCCOCCOCCS(=O)(=O)N3CCN(CC3)[C@H]3CC[C@@H](CC3)Nc3ncnc4ccc(cc34)C#N)ccc12
Show InChI InChI=1S/C40H48N8O10S/c41-25-27-1-8-34-33(23-27)37(43-26-42-34)44-28-2-4-29(5-3-28)46-11-13-47(14-12-46)59(53,54)22-21-57-18-17-55-15-16-56-19-20-58-30-6-7-31-32(24-30)40(52)48(39(31)51)35-9-10-36(49)45-38(35)50/h1,6-8,23-24,26,28-29,35H,2-5,9-22H2,(H,42,43,44)(H,45,49,50)/t28-,29-,35?
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504479
PNG
(N-(5-((4-(2-((2-(2,6- dioxopiperidin-3-yl)-1,3- di...)
Show SMILES COc1cccc(c1)-n1c(NC(=O)c2cccc(c2)C(F)(F)F)nc2cc(CN3CCN(CCOc4ccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c5c4)CC3)ccc12
Show InChI InChI=1S/C42H38F3N7O7/c1-58-29-7-3-6-28(22-29)51-34-11-8-25(20-33(34)46-41(51)48-37(54)26-4-2-5-27(21-26)42(43,44)45)24-50-16-14-49(15-17-50)18-19-59-30-9-10-31-32(23-30)40(57)52(39(31)56)35-12-13-36(53)47-38(35)55/h2-11,20-23,35H,12-19,24H2,1H3,(H,46,48,54)(H,47,53,55)
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM504456
PNG
(4-((1r,4r)-4-(4-((2-(2-(2-((2- (2,6-dioxopiperidin...)
Show SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)c2cc(OCCOCCOCCS(=O)(=O)N3CCN(CC3)[C@H]3CC[C@@H](CC3)Nc3ncnc4ccc(cc34)C#N)ccc12
Show InChI InChI=1S/C38H44N8O9S/c39-23-25-1-8-32-31(21-25)35(41-24-40-32)42-26-2-4-27(5-3-26)44-11-13-45(14-12-44)56(51,52)20-19-54-16-15-53-17-18-55-28-6-7-29-30(22-28)38(50)46(37(29)49)33-9-10-34(47)43-36(33)48/h1,6-8,21-22,24,26-27,33H,2-5,9-20H2,(H,40,41,42)(H,43,47,48)/t26-,27-,33?
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ARVINAS OPERATIONS, INC.

US Patent


Assay Description
A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...


US Patent US11065231 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%