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Patent code US11066363

Compile Data Set for Download or QSAR
Found 22 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM50500359
PNG
(CHEMBL3747611 | US11066363, Compound 13)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cnn[nH]1
Show InChI InChI=1S/C23H19N5O/c1-4-13-8-16-17(9-15(13)19-11-25-28-27-19)23(2,3)22-20(21(16)29)14-6-5-12(10-24)7-18(14)26-22/h5-9,11,26H,4H2,1-3H3,(H,25,27,28)
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n/an/a 0.884n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM50500360
PNG
(CHEMBL3747134 | US11066363, Compound 9)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cc[nH]n1
Show InChI InChI=1S/C24H20N4O/c1-4-14-10-17-18(11-16(14)19-7-8-26-28-19)24(2,3)23-21(22(17)29)15-6-5-13(12-25)9-20(15)27-23/h5-11,27H,4H2,1-3H3,(H,26,28)
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n/an/a 1.15n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM50500357
PNG
(CHEMBL3746522 | US11066363, Compound 31)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cnn(CCN(C)C)c1
Show InChI InChI=1S/C28H29N5O/c1-6-18-12-22-23(13-21(18)19-15-30-33(16-19)10-9-32(4)5)28(2,3)27-25(26(22)34)20-8-7-17(14-29)11-24(20)31-27/h7-8,11-13,15-16,31H,6,9-10H2,1-5H3
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n/an/a 1.91n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM504520
PNG
(9-ethyl-6,6-dimethyl-11-oxo-8- (pyrimidin-5-yl)-6,...)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cncnc1
Show InChI InChI=1S/C25H20N4O/c1-4-15-8-19-20(9-18(15)16-11-27-13-28-12-16)25(2,3)24-22(23(19)30)17-6-5-14(10-26)7-21(17)29-24/h5-9,11-13,29H,4H2,1-3H3
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n/an/a 2.53n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM504519
PNG
((9-ethyl-6,6-dimethyl-11-oxo-8- (pyridin-4-yl)-6,1...)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1ccncc1
Show InChI InChI=1S/C26H21N3O/c1-4-16-12-20-21(13-19(16)17-7-9-28-10-8-17)26(2,3)25-23(24(20)30)18-6-5-15(14-27)11-22(18)29-25/h5-13,29H,4H2,1-3H3
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n/an/a 2.61n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM50500351
PNG
(CHEMBL3746960 | US11066363, Compound 19)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1N1CCN(C)CC1
Show InChI InChI=1S/C26H28N4O/c1-5-17-13-19-20(14-22(17)30-10-8-29(4)9-11-30)26(2,3)25-23(24(19)31)18-7-6-16(15-27)12-21(18)28-25/h6-7,12-14,28H,5,8-11H2,1-4H3
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n/an/a 2.66n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM50500356
PNG
(CHEMBL3747406 | US11066363, Compound 7)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cnn(C)c1
Show InChI InChI=1S/C25H22N4O/c1-5-15-9-19-20(10-18(15)16-12-27-29(4)13-16)25(2,3)24-22(23(19)30)17-7-6-14(11-26)8-21(17)28-24/h6-10,12-13,28H,5H2,1-4H3
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n/an/a 3.01n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM50500355
PNG
(CHEMBL3747108 | US11066363, Compound 36)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cnn(c1)C(=O)N(C)C
Show InChI InChI=1S/C27H25N5O2/c1-6-16-10-20-21(11-19(16)17-13-29-32(14-17)26(34)31(4)5)27(2,3)25-23(24(20)33)18-8-7-15(12-28)9-22(18)30-25/h7-11,13-14,30H,6H2,1-5H3
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n/an/a 4.75n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM50500353
PNG
(CHEMBL3746395 | US11066363, Compound 10)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cnoc1
Show InChI InChI=1S/C24H19N3O2/c1-4-14-8-18-19(9-17(14)15-11-26-29-12-15)24(2,3)23-21(22(18)28)16-6-5-13(10-25)7-20(16)27-23/h5-9,11-12,27H,4H2,1-3H3
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n/an/a 5.09n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK2


(Homo sapiens (Human))
BDBM50500357
PNG
(CHEMBL3746522 | US11066363, Compound 31)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cnn(CCN(C)C)c1
Show InChI InChI=1S/C28H29N5O/c1-6-18-12-22-23(13-21(18)19-15-30-33(16-19)10-9-32(4)5)28(2,3)27-25(26(22)34)20-8-7-17(14-29)11-24(20)31-27/h7-8,11-13,15-16,31H,6,9-10H2,1-5H3
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n/an/a 6.60n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK2


(Homo sapiens (Human))
BDBM50500359
PNG
(CHEMBL3747611 | US11066363, Compound 13)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cnn[nH]1
Show InChI InChI=1S/C23H19N5O/c1-4-13-8-16-17(9-15(13)19-11-25-28-27-19)23(2,3)22-20(21(16)29)14-6-5-12(10-24)7-18(14)26-22/h5-9,11,26H,4H2,1-3H3,(H,25,27,28)
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n/an/a 7.46n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK2


(Homo sapiens (Human))
BDBM50500351
PNG
(CHEMBL3746960 | US11066363, Compound 19)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1N1CCN(C)CC1
Show InChI InChI=1S/C26H28N4O/c1-5-17-13-19-20(14-22(17)30-10-8-29(4)9-11-30)26(2,3)25-23(24(19)31)18-7-6-16(15-27)12-21(18)28-25/h6-7,12-14,28H,5,8-11H2,1-4H3
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n/an/a 8.57n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM50362781
PNG
(1256580-46-7 | AF802 | Alecensa | Alectinib | CH54...)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C30H34N4O2/c1-4-20-16-23-24(17-26(20)34-9-7-21(8-10-34)33-11-13-36-14-12-33)30(2,3)29-27(28(23)35)22-6-5-19(18-31)15-25(22)32-29/h5-6,15-17,21,32H,4,7-14H2,1-3H3
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n/an/a 11n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase SRPK2


(Homo sapiens (Human))
BDBM50500356
PNG
(CHEMBL3747406 | US11066363, Compound 7)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cnn(C)c1
Show InChI InChI=1S/C25H22N4O/c1-5-15-9-19-20(10-18(15)16-12-27-29(4)13-16)25(2,3)24-22(23(19)30)17-7-6-14(11-26)8-21(17)28-24/h6-10,12-13,28H,5H2,1-4H3
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n/an/a 12.4n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK2


(Homo sapiens (Human))
BDBM504520
PNG
(9-ethyl-6,6-dimethyl-11-oxo-8- (pyrimidin-5-yl)-6,...)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cncnc1
Show InChI InChI=1S/C25H20N4O/c1-4-15-8-19-20(9-18(15)16-11-27-13-28-12-16)25(2,3)24-22(23(19)30)17-6-5-14(10-26)7-21(17)29-24/h5-9,11-13,29H,4H2,1-3H3
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n/an/a 12.5n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK2


(Homo sapiens (Human))
BDBM504519
PNG
((9-ethyl-6,6-dimethyl-11-oxo-8- (pyridin-4-yl)-6,1...)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1ccncc1
Show InChI InChI=1S/C26H21N3O/c1-4-16-12-20-21(13-19(16)17-7-9-28-10-8-17)26(2,3)25-23(24(20)30)18-6-5-15(14-27)11-22(18)29-25/h5-13,29H,4H2,1-3H3
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n/an/a 13.2n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK2


(Homo sapiens (Human))
BDBM50500353
PNG
(CHEMBL3746395 | US11066363, Compound 10)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cnoc1
Show InChI InChI=1S/C24H19N3O2/c1-4-14-8-18-19(9-17(14)15-11-26-29-12-15)24(2,3)23-21(22(18)28)16-6-5-13(10-25)7-20(16)27-23/h5-9,11-12,27H,4H2,1-3H3
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n/an/a 14.5n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK2


(Homo sapiens (Human))
BDBM50500355
PNG
(CHEMBL3747108 | US11066363, Compound 36)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cnn(c1)C(=O)N(C)C
Show InChI InChI=1S/C27H25N5O2/c1-6-16-10-20-21(11-19(16)17-13-29-32(14-17)26(34)31(4)5)27(2,3)25-23(24(20)33)18-8-7-15(12-28)9-22(18)30-25/h7-11,13-14,30H,6H2,1-5H3
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n/an/a 23.6n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK2


(Homo sapiens (Human))
BDBM50362781
PNG
(1256580-46-7 | AF802 | Alecensa | Alectinib | CH54...)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C30H34N4O2/c1-4-20-16-23-24(17-26(20)34-9-7-21(8-10-34)33-11-13-36-14-12-33)30(2,3)29-27(28(23)35)22-6-5-19(18-31)15-25(22)32-29/h5-6,15-17,21,32H,4,7-14H2,1-3H3
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n/an/a 28.2n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM50512854
PNG
(CHEMBL4468747 | US11066363, Compound 37)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cccc(c1)S(F)(=O)=O
Show InChI InChI=1S/C27H21FN2O3S/c1-4-16-12-21-22(13-20(16)17-6-5-7-18(11-17)34(28,32)33)27(2,3)26-24(25(21)31)19-9-8-15(14-29)10-23(19)30-26/h5-13,30H,4H2,1-3H3
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n/an/a 35.6n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM504532
PNG
(4-(3-cyano-9-ethyl-6,6-dimethyl-11- oxo-6,11-dihyd...)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1ccc(cc1)S(F)(=O)=O
Show InChI InChI=1S/C27H21FN2O3S/c1-4-16-12-21-22(13-20(16)17-6-8-18(9-7-17)34(28,32)33)27(2,3)26-24(25(21)31)19-10-5-15(14-29)11-23(19)30-26/h5-13,30H,4H2,1-3H3
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n/an/a 41n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM50500352
PNG
(CHEMBL3746665 | US11066363, Compound 17)
Show SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1N1CCC(CC1)N(C)C
Show InChI InChI=1S/C28H32N4O/c1-6-18-14-21-22(15-24(18)32-11-9-19(10-12-32)31(4)5)28(2,3)27-25(26(21)33)20-8-7-17(16-29)13-23(20)30-27/h7-8,13-15,19,30H,6,9-12H2,1-5H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>103n/an/an/an/an/an/a



DANA-FARBER CANCER INSTITUTE, INC.

US Patent


Assay Description
SRPK1 Inhibitory Activities of the Compounds.


US Patent US11066363 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%