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Patent code US11066365

Compile Data Set for Download or QSAR

Found 273 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404503
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-1-(cyclopropylmethy...)
Show SMILES Cc1noc(C)c1-c1ccc2c(nn(CC3CC3)c2c1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C22H24N6O2/c1-13-20(14(2)30-26-13)16-5-6-18-19(9-16)28(10-15-3-4-15)25-21(18)22(29)24-17-7-8-27(11-17)12-23/h5-6,9,15,17H,3-4,7-8,10-11H2,1-2H3,(H,24,29)/t17-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404540
PNG
((R)-3-(3-chlorophenyl)-N-(1-cyanopyrrolidin-3-yl)a...)
Show SMILES Clc1cccc(c1)C1CN(C1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C15H17ClN4O/c16-13-3-1-2-11(6-13)12-7-20(8-12)15(21)18-14-4-5-19(9-14)10-17/h1-3,6,12,14H,4-5,7-9H2,(H,18,21)/t14-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM505531
PNG
((3aR,6aR)-5-cyano-N-(4- (trifluoromethyl)-phenyl)-...)
Show SMILES FC(F)(F)c1ccc(NC(=O)N2CC[C@@H]3CN(C[C@H]23)C#N)cc1
Show InChI InChI=1S/C15H15F3N4O/c16-15(17,18)11-1-3-12(4-2-11)20-14(23)22-6-5-10-7-21(9-19)8-13(10)22/h1-4,10,13H,5-8H2,(H,20,23)/t10-,13+/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404552
PNG
((R)-1-(1-cyanopyrrolidin-3-yl)-1-ethyl-3-(4-(trifl...)
Show SMILES CCN([C@@H]1CCN(C1)C#N)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H17F3N4O/c1-2-22(13-7-8-21(9-13)10-19)14(23)20-12-5-3-11(4-6-12)15(16,17)18/h3-6,13H,2,7-9H2,1H3,(H,20,23)/t13-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404602
PNG
(1-[1,1''-biphenyl]-4-yl)-3-(1- cyanopyrrolidin-3-y...)
Show SMILES O=C(NC1CCN(C1)C#N)Nc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C18H18N4O/c19-13-22-11-10-17(12-22)21-18(23)20-16-8-6-15(7-9-16)14-4-2-1-3-5-14/h1-9,17H,10-12H2,(H2,20,21,23)
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404382
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)- [1,1'-biphenyl]-4-...)
Show SMILES O=C(N[C@@H]1CCN(C1)C#N)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C18H17N3O/c19-13-21-11-10-17(12-21)20-18(22)16-8-6-15(7-9-16)14-4-2-1-3-5-14/h1-9,17H,10-12H2,(H,20,22)/t17-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404384
PNG
((R)-2-(2-chlorophenyl)-N-(1- cyanopyrrolidin-3-yl)...)
Show SMILES Clc1ccccc1-c1ncc(s1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C15H13ClN4OS/c16-12-4-2-1-3-11(12)15-18-7-13(22-15)14(21)19-10-5-6-20(8-10)9-17/h1-4,7,10H,5-6,8H2,(H,19,21)/t10-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404433
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-2- fluoro-4-(5-(tri...)
Show SMILES Fc1cc(ccc1C(=O)N[C@@H]1CCN(C1)C#N)-c1cn[nH]c1C(F)(F)F
Show InChI InChI=1S/C16H13F4N5O/c17-13-5-9(12-6-22-24-14(12)16(18,19)20)1-2-11(13)15(26)23-10-3-4-25(7-10)8-21/h1-2,5-6,10H,3-4,7H2,(H,22,24)(H,23,26)/t10-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404469
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-3-fluoro-5-(1-meth...)
Show SMILES Cn1ccc2cc(cnc12)-c1cnc(C(=O)N[C@@H]2CCN(C2)C#N)c(F)c1
Show InChI InChI=1S/C19H17FN6O/c1-25-4-2-12-6-13(9-23-18(12)25)14-7-16(20)17(22-8-14)19(27)24-15-3-5-26(10-15)11-21/h2,4,6-9,15H,3,5,10H2,1H3,(H,24,27)/t15-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404505
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-N-methyl-5-(1-methy...)
Show SMILES CN([C@@H]1CCN(C1)C#N)C(=O)c1cc2cc(ccc2[nH]1)-c1cnn(C)c1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM447634
PNG
((R)—N-(1-cyanopyrrolidin-3-yl)-5-(4-fluorophe...)
Show SMILES CC(C)(C)OC(=O)N1CC[C@H](C1)NC(=O)c1ccc(Br)cn1
Show InChI InChI=1S/C15H20BrN3O3/c1-15(2,3)22-14(21)19-7-6-11(9-19)18-13(20)12-5-4-10(16)8-17-12/h4-5,8,11H,6-7,9H2,1-3H3,(H,18,20)/t11-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM447658
PNG
((3aR,6aR)-5-cyano-N-(2- fluoro-4-(trifluoromethoxy...)
Show SMILES Fc1cc(OC(F)(F)F)ccc1NC(=O)N1CC[C@@H]2CN(C[C@H]12)C#N
Show InChI InChI=1S/C15H14F4N4O2/c16-11-5-10(25-15(17,18)19)1-2-12(11)21-14(24)23-4-3-9-6-22(8-20)7-13(9)23/h1-2,5,9,13H,3-4,6-7H2,(H,21,24)/t9-,13+/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404582
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-3-(1-phenyl-1H-pyra...)
Show SMILES O=C(N[C@@H]1CCN(C1)C#N)N1CC(C1)c1ccn(n1)-c1ccccc1
Show InChI InChI=1S/C18H20N6O/c19-13-22-8-6-15(12-22)20-18(25)23-10-14(11-23)17-7-9-24(21-17)16-4-2-1-3-5-16/h1-5,7,9,14-15H,6,8,10-12H2,(H,20,25)/t15-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404589
PNG
((3aR,6aR)-5-cyano-N-(3-(2-methylpyridin-4-yl)pheny...)
Show SMILES Cc1cc(ccn1)-c1cccc(NC(=O)N2CC[C@@H]3CN(C[C@H]23)C#N)c1
Show InChI InChI=1S/C20H21N5O/c1-14-9-16(5-7-22-14)15-3-2-4-18(10-15)23-20(26)25-8-6-17-11-24(13-21)12-19(17)25/h2-5,7,9-10,17,19H,6,8,11-12H2,1H3,(H,23,26)/t17-,19+/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404619
PNG
((R)-N-(1- cyanopyrrolidin- 3-yl)-3-(3,4- dimethylp...)
Show SMILES Cc1ccc(cc1C)-c1cc(on1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C17H18N4O2/c1-11-3-4-13(7-12(11)2)15-8-16(23-20-15)17(22)19-14-5-6-21(9-14)10-18/h3-4,7-8,14H,5-6,9H2,1-2H3,(H,19,22)/t14-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404383
PNG
((R)-6-(4-chlorophenyl)-N-(1- cyanopyrrolidin-3-yl)...)
Show SMILES Clc1ccc(cc1)-c1ccc(cn1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C17H15ClN4O/c18-14-4-1-12(2-5-14)16-6-3-13(9-20-16)17(23)21-15-7-8-22(10-15)11-19/h1-6,9,15H,7-8,10H2,(H,21,23)/t15-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404386
PNG
((R)-4-(3-chloropyridin-4-yl)-N- (1-cyanopyrrolidin...)
Show SMILES COc1cc(ccc1-c1ccncc1Cl)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C18H17ClN4O2/c1-25-17-8-12(18(24)22-13-5-7-23(10-13)11-20)2-3-15(17)14-4-6-21-9-16(14)19/h2-4,6,8-9,13H,5,7,10H2,1H3,(H,22,24)/t13-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404490
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-3-fluoro-4- (pyrim...)
Show SMILES Fc1cc(ccc1Nc1ncccn1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C16H15FN6O/c17-13-8-11(15(24)21-12-4-7-23(9-12)10-18)2-3-14(13)22-16-19-5-1-6-20-16/h1-3,5-6,8,12H,4,7,9H2,(H,21,24)(H,19,20,22)/t12-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404493
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-2,5-difluoro-4- (p...)
Show SMILES Fc1cc(C(=O)N[C@@H]2CCN(C2)C#N)c(F)cc1N1CCCC1
Show InChI InChI=1S/C16H18F2N4O/c17-13-8-15(22-4-1-2-5-22)14(18)7-12(13)16(23)20-11-3-6-21(9-11)10-19/h7-8,11H,1-6,9H2,(H,20,23)/t11-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404508
PNG
((R)-7-(3-cyanophenyl)-N-(1-cyanopyrrolidin-3-yl)im...)
Show SMILES O=C(N[C@@H]1CCN(C1)C#N)c1cnc2cc(ccn12)-c1cccc(c1)C#N
Show InChI InChI=1S/C20H16N6O/c21-10-14-2-1-3-15(8-14)16-4-7-26-18(11-23-19(26)9-16)20(27)24-17-5-6-25(12-17)13-22/h1-4,7-9,11,17H,5-6,12H2,(H,24,27)/t17-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404520
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-2-fluoro-4-(pyrazol...)
Show SMILES Fc1cc(ccc1C(=O)N[C@@H]1CCN(C1)C#N)-c1ccn2nccc2n1
Show InChI InChI=1S/C18H15FN6O/c19-15-9-12(16-5-8-25-17(23-16)3-6-21-25)1-2-14(15)18(26)22-13-4-7-24(10-13)11-20/h1-3,5-6,8-9,13H,4,7,10H2,(H,22,26)/t13-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM505530
PNG
((3aR,6aR)-5-cyano-N-(5- phenyl-pyridin-2-yl) hexah...)
Show SMILES O=C(Nc1ccc(cn1)-c1ccccc1)N1CC[C@@H]2CN(C[C@H]12)C#N
Show InChI InChI=1S/C19H19N5O/c20-13-23-11-16-8-9-24(17(16)12-23)19(25)22-18-7-6-15(10-21-18)14-4-2-1-3-5-14/h1-7,10,16-17H,8-9,11-12H2,(H,21,22,25)/t16-,17+/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404561
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-4-((4-cyclopropylpy...)
Show SMILES Fc1cc(ccc1Nc1nccc(n1)C1CC1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C19H19FN6O/c20-15-9-13(18(27)23-14-6-8-26(10-14)11-21)3-4-17(15)25-19-22-7-5-16(24-19)12-1-2-12/h3-5,7,9,12,14H,1-2,6,8,10H2,(H,23,27)(H,22,24,25)/t14-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404562
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-4-((4-cyclopropylpy...)
Show SMILES Fc1c(Nc2nccc(n2)C2CC2)ccc(C(=O)N[C@@H]2CCN(C2)C#N)c1F
Show InChI InChI=1S/C19H18F2N6O/c20-16-13(18(28)24-12-6-8-27(9-12)10-22)3-4-15(17(16)21)26-19-23-7-5-14(25-19)11-1-2-11/h3-5,7,11-12H,1-2,6,8-9H2,(H,24,28)(H,23,25,26)/t12-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404580
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-3-fluoro-1-methyl-5...)
Show SMILES Cn1cc(cn1)-c1ccc2n(C)c(C(=O)N[C@@H]3CCN(C3)C#N)c(F)c2c1
Show InChI InChI=1S/C19H19FN6O/c1-24-9-13(8-22-24)12-3-4-16-15(7-12)17(20)18(25(16)2)19(27)23-14-5-6-26(10-14)11-21/h3-4,7-9,14H,5-6,10H2,1-2H3,(H,23,27)/t14-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404586
PNG
((R)-3-(benzyloxy)-N-(1-cyanopyrrolidin-3-yl)-3-phe...)
Show SMILES O=C(N[C@@H]1CCN(C1)C#N)N1CC(C1)(OCc1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H24N4O2/c23-17-25-12-11-20(13-25)24-21(27)26-15-22(16-26,19-9-5-2-6-10-19)28-14-18-7-3-1-4-8-18/h1-10,20H,11-16H2,(H,24,27)/t20-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM447722
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-6- (3,5-dimethyliso...)
Show SMILES CN([C@@H]1CCN(C1)C#N)C(=O)c1cc2ccc(cc2[nH]1)-c1c(C)noc1C
Show InChI InChI=1S/C20H21N5O2/c1-12-19(13(2)27-23-12)15-5-4-14-8-18(22-17(14)9-15)20(26)24(3)16-6-7-25(10-16)11-21/h4-5,8-9,16,22H,6-7,10H2,1-3H3/t16-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404387
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-3- methoxy-4-(2-met...)
Show SMILES COc1cc(ccc1-c1ccnc(C)c1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C19H20N4O2/c1-13-9-14(5-7-21-13)17-4-3-15(10-18(17)25-2)19(24)22-16-6-8-23(11-16)12-20/h3-5,7,9-10,16H,6,8,11H2,1-2H3,(H,22,24)/t16-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404428
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-4- (1,3-dimethyl-1H...)
Show SMILES Cc1nn(C)cc1-c1ccc(C(=O)N[C@@H]2CCN(C2)C#N)c(F)c1
Show InChI InChI=1S/C17H18FN5O/c1-11-15(9-22(2)21-11)12-3-4-14(16(18)7-12)17(24)20-13-5-6-23(8-13)10-19/h3-4,7,9,13H,5-6,8H2,1-2H3,(H,20,24)/t13-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404446
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-5-(2-fluorophenyl)...)
Show SMILES Fc1ccccc1-c1cc(n[nH]1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C15H14FN5O/c16-12-4-2-1-3-11(12)13-7-14(20-19-13)15(22)18-10-5-6-21(8-10)9-17/h1-4,7,10H,5-6,8H2,(H,18,22)(H,19,20)/t10-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404468
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-3-fluoro-5-(1-meth...)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc(C(=O)N[C@@H]2CCN(C2)C#N)c(F)c1
Show InChI InChI=1S/C19H17FN6O/c1-25-17-3-2-12(6-14(17)9-23-25)13-7-16(20)18(22-8-13)19(27)24-15-4-5-26(10-15)11-21/h2-3,6-9,15H,4-5,10H2,1H3,(H,24,27)/t15-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404471
PNG
((R)-3-chloro-N-(1- cyanopyrrolidin-3-yl)-5-(4- flu...)
Show SMILES Fc1ccc(cc1)-c1cnc(C(=O)N[C@@H]2CCN(C2)C#N)c(Cl)c1
Show InChI InChI=1S/C17H14ClFN4O/c18-15-7-12(11-1-3-13(19)4-2-11)8-21-16(15)17(24)22-14-5-6-23(9-14)10-20/h1-4,7-8,14H,5-6,9H2,(H,22,24)/t14-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404532
PNG
((R)-N-(1- cyanopyrrolidin- 3-yl)-2-fluoro-4- (2-me...)
Show SMILES Cc1nc2nccc2c([nH]1)-c1ccc(C(=O)N[C@@H]2CCN(C2)C#N)c(F)c1
Show InChI InChI=1S/C19H17FN6O/c1-11-23-17(15-4-6-22-18(15)24-11)12-2-3-14(16(20)8-12)19(27)25-13-5-7-26(9-13)10-21/h2-4,6,8,13H,5,7,9H2,1H3,(H,25,27)(H,22,23,24)/t13-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404569
PNG
((R)-N-(1-cyanopyrrolidin-3-yl)-3-(3-methoxyphenyl)...)
Show SMILES COc1cccc(c1)-c1cc(on1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C16H16N4O3/c1-22-13-4-2-3-11(7-13)14-8-15(23-19-14)16(21)18-12-5-6-20(9-12)10-17/h2-4,7-8,12H,5-6,9H2,1H3,(H,18,21)/t12-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404585
PNG
((R)-3-(2-(4-chlorophenyl)pyrimidin-4-yl)-N-(1-cyan...)
Show SMILES Clc1ccc(cc1)-c1nccc(n1)C1CN(C1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C19H19ClN6O/c20-15-3-1-13(2-4-15)18-22-7-5-17(24-18)14-9-26(10-14)19(27)23-16-6-8-25(11-16)12-21/h1-5,7,14,16H,6,8-11H2,(H,23,27)/t16-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404349
PNG
(3-(3-chlorophenyl)-N-(1- cyanopyrrolidin-3-yl)isox...)
Show SMILES Clc1cccc(c1)-c1cc(on1)C(=O)NC1CCN(C1)C#N
Show InChI InChI=1S/C15H13ClN4O2/c16-11-3-1-2-10(6-11)13-7-14(22-19-13)15(21)18-12-4-5-20(8-12)9-17/h1-3,6-7,12H,4-5,8H2,(H,18,21)
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM504675
PNG
(US11066365, Example 51 | rac-(3aR,6aR)-1-([1,1'-bi...)
Show SMILES O=C(N1CC[C@@H]2CN(C[C@H]12)C#N)c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C20H19N3O/c21-14-22-12-18-9-10-23(19(18)13-22)20(24)17-8-4-7-16(11-17)15-5-2-1-3-6-15/h1-8,11,18-19H,9-10,12-13H2/t18-,19+/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404438
PNG
((3aR,6aR)-5-cyano-N-(2-fluoro-4-(trifluoromethyl)p...)
Show SMILES Fc1cc(ccc1NC(=O)N1CC[C@@H]2CN(C[C@H]12)C#N)C(F)(F)F
Show InChI InChI=1S/C15H14F4N4O/c16-11-5-10(15(17,18)19)1-2-12(11)21-14(24)23-4-3-9-6-22(8-20)7-13(9)23/h1-2,5,9,13H,3-4,6-7H2,(H,21,24)/t9-,13+/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404491
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-2-fluoro-4-(pyrrol...)
Show SMILES Fc1cc(ccc1C(=O)N[C@@H]1CCN(C1)C#N)N1CCCC1
Show InChI InChI=1S/C16H19FN4O/c17-15-9-13(21-6-1-2-7-21)3-4-14(15)16(22)19-12-5-8-20(10-12)11-18/h3-4,9,12H,1-2,5-8,10H2,(H,19,22)/t12-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404515
PNG
((R)-6-(3-cyanophenyl)-N-(1-cyanopyrrolidin-3-yl)-3...)
Show SMILES Fc1c(nc2ccc(cn12)-c1cccc(c1)C#N)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C20H15FN6O/c21-19-18(20(28)24-16-6-7-26(11-16)12-23)25-17-5-4-15(10-27(17)19)14-3-1-2-13(8-14)9-22/h1-5,8,10,16H,6-7,11H2,(H,24,28)/t16-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404539
PNG
((R)-3-(4-chlorophenyl)-N-(1-cyanopyrrolidin-3-yl)a...)
Show SMILES Clc1ccc(cc1)C1CN(C1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C15H17ClN4O/c16-13-3-1-11(2-4-13)12-7-20(8-12)15(21)18-14-5-6-19(9-14)10-17/h1-4,12,14H,5-9H2,(H,18,21)/t14-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM505558
PNG
((R)?N-(1-cyanopyrrolidin-3-yl)-1-methyl-5-(1-methy...)
Show SMILES Cn1cc(cn1)-c1ccc2n(C)c(cc2c1)C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C19H20N6O/c1-23-10-15(9-21-23)13-3-4-17-14(7-13)8-18(24(17)2)19(26)22-16-5-6-25(11-16)12-20/h3-4,7-10,16H,5-6,11H2,1-2H3,(H,22,26)/t16-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404592
PNG
((3aR,6aR)-5- cyano-N-(2'- methyl-[3,4'- bipyridin]...)
Show SMILES Cc1cc(ccn1)-c1ccc(NC(=O)N2CC[C@@H]3CN(C[C@H]23)C#N)nc1
Show InChI InChI=1S/C19H20N6O/c1-13-8-14(4-6-21-13)15-2-3-18(22-9-15)23-19(26)25-7-5-16-10-24(12-20)11-17(16)25/h2-4,6,8-9,16-17H,5,7,10-11H2,1H3,(H,22,23,26)/t16-,17+/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404355
PNG
(N-(1-cyanopyrrolidin-3-yl)-2'- methoxy-[1,1'-biphe...)
Show SMILES COc1ccccc1-c1ccc(cc1)C(=O)NC1CCN(C1)C#N
Show InChI InChI=1S/C19H19N3O2/c1-24-18-5-3-2-4-17(18)14-6-8-15(9-7-14)19(23)21-16-10-11-22(12-16)13-20/h2-9,16H,10-12H2,1H3,(H,21,23)
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n/an/a<100n/an/an/an/an/an/a



Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404418
PNG
(US10343992, Example 70 | US10689345, Example 70 | ...)
Show SMILES C[C@@H]1CN(C[C@H]1NC(=O)c1ncc(s1)-c1ccccc1)C#N
Show InChI InChI=1S/C16H16N4OS/c1-11-8-20(10-17)9-13(11)19-15(21)16-18-7-14(22-16)12-5-3-2-4-6-12/h2-7,11,13H,8-9H2,1H3,(H,19,21)/t11-,13-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404420
PNG
(US10343992, Example 72 | US10689345, Example 72 | ...)
Show SMILES C[C@@H]1CN(C[C@H]1NC(=O)c1cnc(s1)-c1ccccc1)C#N
Show InChI InChI=1S/C16H16N4OS/c1-11-8-20(10-17)9-13(11)19-15(21)14-7-18-16(22-14)12-5-3-2-4-6-12/h2-7,11,13H,8-9H2,1H3,(H,19,21)/t11-,13-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404439
PNG
(US10343992, Example 91 | US10689345, Example 91 | ...)
Show SMILES Fc1cc(Nc2ncccn2)ccc1C(=O)N[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C16H15FN6O/c17-14-8-11(22-16-19-5-1-6-20-16)2-3-13(14)15(24)21-12-4-7-23(9-12)10-18/h1-3,5-6,8,12H,4,7,9H2,(H,21,24)(H,19,20,22)/t12-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404453
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-2-fluoro-4-(2- met...)
Show SMILES Cc1nccc(n1)-c1ccc(C(=O)N[C@@H]2CCN(C2)C#N)c(F)c1
Show InChI InChI=1S/C17H16FN5O/c1-11-20-6-4-16(21-11)12-2-3-14(15(18)8-12)17(24)22-13-5-7-23(9-13)10-19/h2-4,6,8,13H,5,7,9H2,1H3,(H,22,24)/t13-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404474
PNG
((R)-N-(1-cyanopyrrolidin- 3-yl)-5-(1-methyl-1H- py...)
Show SMILES Cn1cc(cn1)-c1ccc2[nH]nc(C(=O)N[C@@H]3CCN(C3)C#N)c2c1
Show InChI InChI=1S/C17H17N7O/c1-23-8-12(7-19-23)11-2-3-15-14(6-11)16(22-21-15)17(25)20-13-4-5-24(9-13)10-18/h2-3,6-8,13H,4-5,9H2,1H3,(H,20,25)(H,21,22)/t13-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 30


(Homo sapiens (Human))
BDBM404533
PNG
((R)-N-(1- cyanopyrrolidin- 3-yl)-2-fluoro-4- (imid...)
Show SMILES Fc1cc(ccc1C(=O)N[C@@H]1CCN(C1)C#N)-c1cnc2cnccn12
Show InChI InChI=1S/C18H15FN6O/c19-15-7-12(16-8-22-17-9-21-4-6-25(16)17)1-2-14(15)18(26)23-13-3-5-24(10-13)11-20/h1-2,4,6-9,13H,3,5,10H2,(H,23,26)/t13-/m1/s1
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Mission Therapeutics Limited

US Patent


Assay Description
USP30 biochemical fluorescence intensity IC50 assay Dilution plates were prepared at 21 times the final concentration (2100 μM for a final conce...


US Patent US11066365 (2021)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%