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Patent code US11066406

Compile Data Set for Download or QSAR
Found 60 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
JAK1 (aa 574-1154)


(Homo sapiens (Human))
BDBM505112
PNG
(US11066406, Ex. 6)
Show SMILES O=C(Cc1nc2cnc3[nH]ccc3c2n1C1(CC#N)CCCCC1)NCC1CCOCC1
Show InChI InChI=1S/C24H30N6O2/c25-10-9-24(7-2-1-3-8-24)30-20(14-21(31)27-15-17-5-12-32-13-6-17)29-19-16-28-23-18(22(19)30)4-11-26-23/h4,11,16-17H,1-3,5-9,12-15H2,(H,26,28)(H,27,31)
PDB

GoogleScholar
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK1 (aa 574-1154)


(Homo sapiens (Human))
BDBM505110
PNG
(US11066406, Ex. 4)
Show SMILES O=C(Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)NCCC#N
Show InChI InChI=1S/C21H23N7O/c22-8-1-10-24-19(29)12-18-27-17-13-26-21-16(7-11-25-21)20(17)28(18)15-4-2-14(3-5-15)6-9-23/h7,11,13-15H,1-6,10,12H2,(H,24,29)(H,25,26)
PDB

GoogleScholar
UniChem
US Patent
n/an/a 0.100n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK2 (aa 532-1132)


(Homo sapiens (Human))
BDBM505104
PNG
(US11066406, A)
Show SMILES Cc1nc2ccc3[nH]ccc3c2n1C1CCC(CC1)C#N
Show InChI InChI=1S/C17H18N4/c1-11-20-16-7-6-15-14(8-9-19-15)17(16)21(11)13-4-2-12(10-18)3-5-13/h6-9,12-13,19H,2-5H2,1H3
PDB
MMDB

NCI pathway
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KEGG

DrugBank
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US Patent
n/an/a<0.200n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK1 (aa 574-1154)


(Homo sapiens (Human))
BDBM505109
PNG
(US11066406, Ex. 3)
Show SMILES O=C(Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)NCC1CC1
Show InChI InChI=1S/C22H26N6O/c23-9-7-14-3-5-16(6-4-14)28-19(11-20(29)25-12-15-1-2-15)27-18-13-26-22-17(21(18)28)8-10-24-22/h8,10,13-16H,1-7,11-12H2,(H,24,26)(H,25,29)
PDB

GoogleScholar
UniChem
US Patent
n/an/a 0.200n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK1 (aa 574-1154)


(Homo sapiens (Human))
BDBM505105
PNG
(US11066406, B)
Show SMILES OCc1nc2ccc3[nH]ccc3c2n1C1CCC(CC1)C#N
Show InChI InChI=1S/C17H18N4O/c18-9-11-1-3-12(4-2-11)21-16(10-22)20-15-6-5-14-13(17(15)21)7-8-19-14/h5-8,11-12,19,22H,1-4,10H2
PDB

GoogleScholar
UniChem
US Patent
n/an/a<0.200n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK2 (aa 532-1132)


(Homo sapiens (Human))
BDBM505105
PNG
(US11066406, B)
Show SMILES OCc1nc2ccc3[nH]ccc3c2n1C1CCC(CC1)C#N
Show InChI InChI=1S/C17H18N4O/c18-9-11-1-3-12(4-2-11)21-16(10-22)20-15-6-5-14-13(17(15)21)7-8-19-14/h5-8,11-12,19,22H,1-4,10H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

DrugBank
GoogleScholar
UniChem
US Patent
n/an/a<0.200n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
TYK2 (aa 580-1182)


(Homo sapiens (Human))
BDBM505105
PNG
(US11066406, B)
Show SMILES OCc1nc2ccc3[nH]ccc3c2n1C1CCC(CC1)C#N
Show InChI InChI=1S/C17H18N4O/c18-9-11-1-3-12(4-2-11)21-16(10-22)20-15-6-5-14-13(17(15)21)7-8-19-14/h5-8,11-12,19,22H,1-4,10H2
PDB
MMDB

GoogleScholar
UniChem
US Patent
n/an/a<0.200n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
TYK2 (aa 580-1182)


(Homo sapiens (Human))
BDBM505106
PNG
(US11066406, C)
Show SMILES C[C@H](O)c1nc2ccc3[nH]ccc3c2n1C1CCC(CC1)C#N
PDB
MMDB

GoogleScholar
UniChem
US Patent
n/an/a 0.200n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK1 (aa 574-1154)


(Homo sapiens (Human))
BDBM505108
PNG
(US11066406, Ex. 2)
Show SMILES N#CCC1CCC(CC1)n1c(nc2cnc3[nH]ccc3c12)-c1c[nH]cn1
Show InChI InChI=1S/C19H19N7/c20-7-5-12-1-3-13(4-2-12)26-17-14-6-8-22-18(14)23-10-15(17)25-19(26)16-9-21-11-24-16/h6,8-13H,1-5H2,(H,21,24)(H,22,23)
PDB

GoogleScholar
UniChem
US Patent
n/an/a 0.200n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK1 (aa 574-1154)


(Homo sapiens (Human))
BDBM505113
PNG
(US11066406, Ex. 7)
Show SMILES CC(C)(CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)C#N
Show InChI InChI=1S/C23H27N7O/c1-23(2,13-25)14-28-20(31)11-19-29-18-12-27-22-17(8-10-26-22)21(18)30(19)16-5-3-15(4-6-16)7-9-24/h8,10,12,15-16H,3-7,11,14H2,1-2H3,(H,26,27)(H,28,31)
PDB

GoogleScholar
UniChem
US Patent
n/an/a 0.200n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK1 (aa 574-1154)


(Homo sapiens (Human))
BDBM505106
PNG
(US11066406, C)
Show SMILES C[C@H](O)c1nc2ccc3[nH]ccc3c2n1C1CCC(CC1)C#N
PDB

GoogleScholar
UniChem
US Patent
n/an/a<0.200n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK1 (aa 574-1154)


(Homo sapiens (Human))
BDBM505104
PNG
(US11066406, A)
Show SMILES Cc1nc2ccc3[nH]ccc3c2n1C1CCC(CC1)C#N
Show InChI InChI=1S/C17H18N4/c1-11-20-16-7-6-15-14(8-9-19-15)17(16)21(11)13-4-2-12(10-18)3-5-13/h6-9,12-13,19H,2-5H2,1H3
PDB

GoogleScholar
UniChem
US Patent
n/an/a<0.200n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK1 (aa 574-1154)


(Homo sapiens (Human))
BDBM505115
PNG
(US11066406, Ex. 9)
Show SMILES Cn1cc(NC(=O)Cc2nc3cnc4[nH]ccc4c3n2C2CCC(CC#N)CC2)cn1
Show InChI InChI=1S/C22H24N8O/c1-29-13-15(11-26-29)27-20(31)10-19-28-18-12-25-22-17(7-9-24-22)21(18)30(19)16-4-2-14(3-5-16)6-8-23/h7,9,11-14,16H,2-6,10H2,1H3,(H,24,25)(H,27,31)
PDB

GoogleScholar
UniChem
US Patent
n/an/a 0.200n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK1 (aa 574-1154)


(Homo sapiens (Human))
BDBM505111
PNG
(US11066406, Ex. 5)
Show SMILES O=C(Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)NC1CCOCC1
Show InChI InChI=1S/C23H28N6O2/c24-9-5-15-1-3-17(4-2-15)29-20(13-21(30)27-16-7-11-31-12-8-16)28-19-14-26-23-18(22(19)29)6-10-25-23/h6,10,14-17H,1-5,7-8,11-13H2,(H,25,26)(H,27,30)
PDB

GoogleScholar
UniChem
US Patent
n/an/a 0.300n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK1 (aa 574-1154)


(Homo sapiens (Human))
BDBM505107
PNG
(US11066406, Ex. 1)
Show SMILES CC(C)(O)CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1
Show InChI InChI=1S/C22H28N6O2/c1-22(2,30)13-26-19(29)11-18-27-17-12-25-21-16(8-10-24-21)20(17)28(18)15-5-3-14(4-6-15)7-9-23/h8,10,12,14-15,30H,3-7,11,13H2,1-2H3,(H,24,25)(H,26,29)
PDB

GoogleScholar
UniChem
US Patent
n/an/a 0.400n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK1 (aa 574-1154)


(Homo sapiens (Human))
BDBM505114
PNG
(US11066406, Ex. 8)
Show SMILES OC1(CNC(=O)Cc2nc3cnc4[nH]ccc4c3n2C2CCC(CC#N)CC2)CCC1
Show InChI InChI=1S/C23H28N6O2/c24-10-6-15-2-4-16(5-3-15)29-19(12-20(30)27-14-23(31)8-1-9-23)28-18-13-26-22-17(21(18)29)7-11-25-22/h7,11,13,15-16,31H,1-6,8-9,12,14H2,(H,25,26)(H,27,30)
PDB

GoogleScholar
UniChem
US Patent
n/an/a 0.400n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK1 (aa 574-1154)


(Homo sapiens (Human))
BDBM505117
PNG
(US11066406, Ex. 11)
Show SMILES O=C(Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)Nc1cc[nH]n1
Show InChI InChI=1S/C21H22N8O/c22-8-5-13-1-3-14(4-2-13)29-18(11-19(30)27-17-7-10-25-28-17)26-16-12-24-21-15(20(16)29)6-9-23-21/h6-7,9-10,12-14H,1-5,11H2,(H,23,24)(H2,25,27,28,30)
PDB

GoogleScholar
UniChem
US Patent
n/an/a 0.400n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK2 (aa 532-1132)


(Homo sapiens (Human))
BDBM505106
PNG
(US11066406, C)
Show SMILES C[C@H](O)c1nc2ccc3[nH]ccc3c2n1C1CCC(CC1)C#N
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 0.600n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
TYK2 (aa 580-1182)


(Homo sapiens (Human))
BDBM505104
PNG
(US11066406, A)
Show SMILES Cc1nc2ccc3[nH]ccc3c2n1C1CCC(CC1)C#N
Show InChI InChI=1S/C17H18N4/c1-11-20-16-7-6-15-14(8-9-19-15)17(16)21(11)13-4-2-12(10-18)3-5-13/h6-9,12-13,19H,2-5H2,1H3
PDB
MMDB

GoogleScholar
UniChem
US Patent
n/an/a 0.900n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK1 (aa 574-1154)


(Homo sapiens (Human))
BDBM505118
PNG
(US11066406, Ex. 12)
Show SMILES OC1(CNC(=O)Cc2nc3cnc4[nH]ccc4c3n2C2CCC(CC#N)CC2)CC1
Show InChI InChI=1S/C22H26N6O2/c23-9-5-14-1-3-15(4-2-14)28-18(11-19(29)26-13-22(30)7-8-22)27-17-12-25-21-16(20(17)28)6-10-24-21/h6,10,12,14-15,30H,1-5,7-8,11,13H2,(H,24,25)(H,26,29)
PDB

GoogleScholar
UniChem
US Patent
n/an/a 0.900n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK1 (aa 574-1154)


(Homo sapiens (Human))
BDBM505116
PNG
(US11066406, Ex. 10)
Show SMILES O=C(Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)NC12CCC(CC#N)(CC1)C2
Show InChI InChI=1S/C27H31N7O/c28-12-5-18-1-3-19(4-2-18)34-22(32-21-16-31-25-20(24(21)34)6-14-30-25)15-23(35)33-27-9-7-26(17-27,8-10-27)11-13-29/h6,14,16,18-19H,1-5,7-11,15,17H2,(H,30,31)(H,33,35)
PDB

GoogleScholar
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK2 (aa 532-1132)


(Homo sapiens (Human))
BDBM505108
PNG
(US11066406, Ex. 2)
Show SMILES N#CCC1CCC(CC1)n1c(nc2cnc3[nH]ccc3c12)-c1c[nH]cn1
Show InChI InChI=1S/C19H19N7/c20-7-5-12-1-3-13(4-2-12)26-17-14-6-8-22-18(14)23-10-15(17)25-19(26)16-9-21-11-24-16/h6,8-13H,1-5H2,(H,21,24)(H,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
TYK2 (aa 580-1182)


(Homo sapiens (Human))
BDBM505112
PNG
(US11066406, Ex. 6)
Show SMILES O=C(Cc1nc2cnc3[nH]ccc3c2n1C1(CC#N)CCCCC1)NCC1CCOCC1
Show InChI InChI=1S/C24H30N6O2/c25-10-9-24(7-2-1-3-8-24)30-20(14-21(31)27-15-17-5-12-32-13-6-17)29-19-16-28-23-18(22(19)30)4-11-26-23/h4,11,16-17H,1-3,5-9,12-15H2,(H,26,28)(H,27,31)
PDB
MMDB

GoogleScholar
UniChem
US Patent
n/an/a 1.10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK2 (aa 532-1132)


(Homo sapiens (Human))
BDBM505112
PNG
(US11066406, Ex. 6)
Show SMILES O=C(Cc1nc2cnc3[nH]ccc3c2n1C1(CC#N)CCCCC1)NCC1CCOCC1
Show InChI InChI=1S/C24H30N6O2/c25-10-9-24(7-2-1-3-8-24)30-20(14-21(31)27-15-17-5-12-32-13-6-17)29-19-16-28-23-18(22(19)30)4-11-26-23/h4,11,16-17H,1-3,5-9,12-15H2,(H,26,28)(H,27,31)
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n/an/a 1.40n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
TYK2 (aa 580-1182)


(Homo sapiens (Human))
BDBM505108
PNG
(US11066406, Ex. 2)
Show SMILES N#CCC1CCC(CC1)n1c(nc2cnc3[nH]ccc3c12)-c1c[nH]cn1
Show InChI InChI=1S/C19H19N7/c20-7-5-12-1-3-13(4-2-12)26-17-14-6-8-22-18(14)23-10-15(17)25-19(26)16-9-21-11-24-16/h6,8-13H,1-5H2,(H,21,24)(H,22,23)
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n/an/a 1.5n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
TYK2 (aa 580-1182)


(Homo sapiens (Human))
BDBM505117
PNG
(US11066406, Ex. 11)
Show SMILES O=C(Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)Nc1cc[nH]n1
Show InChI InChI=1S/C21H22N8O/c22-8-5-13-1-3-14(4-2-13)29-18(11-19(30)27-17-7-10-25-28-17)26-16-12-24-21-15(20(16)29)6-9-23-21/h6-7,9-10,12-14H,1-5,11H2,(H,23,24)(H2,25,27,28,30)
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n/an/a 1.5n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK2 (aa 532-1132)


(Homo sapiens (Human))
BDBM505117
PNG
(US11066406, Ex. 11)
Show SMILES O=C(Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)Nc1cc[nH]n1
Show InChI InChI=1S/C21H22N8O/c22-8-5-13-1-3-14(4-2-13)29-18(11-19(30)27-17-7-10-25-28-17)26-16-12-24-21-15(20(16)29)6-9-23-21/h6-7,9-10,12-14H,1-5,11H2,(H,23,24)(H2,25,27,28,30)
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n/an/a 1.60n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK2 (aa 532-1132)


(Homo sapiens (Human))
BDBM505111
PNG
(US11066406, Ex. 5)
Show SMILES O=C(Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)NC1CCOCC1
Show InChI InChI=1S/C23H28N6O2/c24-9-5-15-1-3-17(4-2-15)29-20(13-21(30)27-16-7-11-31-12-8-16)28-19-14-26-23-18(22(19)29)6-10-25-23/h6,10,14-17H,1-5,7-8,11-13H2,(H,25,26)(H,27,30)
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n/an/a 2.10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
TYK2 (aa 580-1182)


(Homo sapiens (Human))
BDBM505110
PNG
(US11066406, Ex. 4)
Show SMILES O=C(Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)NCCC#N
Show InChI InChI=1S/C21H23N7O/c22-8-1-10-24-19(29)12-18-27-17-13-26-21-16(7-11-25-21)20(17)28(18)15-4-2-14(3-5-15)6-9-23/h7,11,13-15H,1-6,10,12H2,(H,24,29)(H,25,26)
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n/an/a 2.20n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
TYK2 (aa 580-1182)


(Homo sapiens (Human))
BDBM505111
PNG
(US11066406, Ex. 5)
Show SMILES O=C(Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)NC1CCOCC1
Show InChI InChI=1S/C23H28N6O2/c24-9-5-15-1-3-17(4-2-15)29-20(13-21(30)27-16-7-11-31-12-8-16)28-19-14-26-23-18(22(19)29)6-10-25-23/h6,10,14-17H,1-5,7-8,11-13H2,(H,25,26)(H,27,30)
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n/an/a 4.10n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
TYK2 (aa 580-1182)


(Homo sapiens (Human))
BDBM505115
PNG
(US11066406, Ex. 9)
Show SMILES Cn1cc(NC(=O)Cc2nc3cnc4[nH]ccc4c3n2C2CCC(CC#N)CC2)cn1
Show InChI InChI=1S/C22H24N8O/c1-29-13-15(11-26-29)27-20(31)10-19-28-18-12-25-22-17(7-9-24-22)21(18)30(19)16-4-2-14(3-5-16)6-8-23/h7,9,11-14,16H,2-6,10H2,1H3,(H,24,25)(H,27,31)
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n/an/a 4.70n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
TYK2 (aa 580-1182)


(Homo sapiens (Human))
BDBM505113
PNG
(US11066406, Ex. 7)
Show SMILES CC(C)(CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)C#N
Show InChI InChI=1S/C23H27N7O/c1-23(2,13-25)14-28-20(31)11-19-29-18-12-27-22-17(8-10-26-22)21(18)30(19)16-5-3-15(4-6-16)7-9-24/h8,10,12,15-16H,3-7,11,14H2,1-2H3,(H,26,27)(H,28,31)
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n/an/a 4.80n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK2 (aa 532-1132)


(Homo sapiens (Human))
BDBM505113
PNG
(US11066406, Ex. 7)
Show SMILES CC(C)(CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)C#N
Show InChI InChI=1S/C23H27N7O/c1-23(2,13-25)14-28-20(31)11-19-29-18-12-27-22-17(8-10-26-22)21(18)30(19)16-5-3-15(4-6-16)7-9-24/h8,10,12,15-16H,3-7,11,14H2,1-2H3,(H,26,27)(H,28,31)
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n/an/a 5.60n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK2 (aa 532-1132)


(Homo sapiens (Human))
BDBM505109
PNG
(US11066406, Ex. 3)
Show SMILES O=C(Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)NCC1CC1
Show InChI InChI=1S/C22H26N6O/c23-9-7-14-3-5-16(6-4-14)28-19(11-20(29)25-12-15-1-2-15)27-18-13-26-22-17(21(18)28)8-10-24-22/h8,10,13-16H,1-7,11-12H2,(H,24,26)(H,25,29)
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n/an/a 6.20n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK2 (aa 532-1132)


(Homo sapiens (Human))
BDBM505116
PNG
(US11066406, Ex. 10)
Show SMILES O=C(Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)NC12CCC(CC#N)(CC1)C2
Show InChI InChI=1S/C27H31N7O/c28-12-5-18-1-3-19(4-2-18)34-22(32-21-16-31-25-20(24(21)34)6-14-30-25)15-23(35)33-27-9-7-26(17-27,8-10-27)11-13-29/h6,14,16,18-19H,1-5,7-11,15,17H2,(H,30,31)(H,33,35)
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n/an/a 6.5n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
TYK2 (aa 580-1182)


(Homo sapiens (Human))
BDBM505114
PNG
(US11066406, Ex. 8)
Show SMILES OC1(CNC(=O)Cc2nc3cnc4[nH]ccc4c3n2C2CCC(CC#N)CC2)CCC1
Show InChI InChI=1S/C23H28N6O2/c24-10-6-15-2-4-16(5-3-15)29-19(12-20(30)27-14-23(31)8-1-9-23)28-18-13-26-22-17(21(18)29)7-11-25-22/h7,11,13,15-16,31H,1-6,8-9,12,14H2,(H,25,26)(H,27,30)
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n/an/a 6.60n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK2 (aa 532-1132)


(Homo sapiens (Human))
BDBM505110
PNG
(US11066406, Ex. 4)
Show SMILES O=C(Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)NCCC#N
Show InChI InChI=1S/C21H23N7O/c22-8-1-10-24-19(29)12-18-27-17-13-26-21-16(7-11-25-21)20(17)28(18)15-4-2-14(3-5-15)6-9-23/h7,11,13-15H,1-6,10,12H2,(H,24,29)(H,25,26)
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n/an/a 6.60n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK2 (aa 532-1132)


(Homo sapiens (Human))
BDBM505115
PNG
(US11066406, Ex. 9)
Show SMILES Cn1cc(NC(=O)Cc2nc3cnc4[nH]ccc4c3n2C2CCC(CC#N)CC2)cn1
Show InChI InChI=1S/C22H24N8O/c1-29-13-15(11-26-29)27-20(31)10-19-28-18-12-25-22-17(7-9-24-22)21(18)30(19)16-4-2-14(3-5-16)6-8-23/h7,9,11-14,16H,2-6,10H2,1H3,(H,24,25)(H,27,31)
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n/an/a 6.60n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK2 (aa 532-1132)


(Homo sapiens (Human))
BDBM505114
PNG
(US11066406, Ex. 8)
Show SMILES OC1(CNC(=O)Cc2nc3cnc4[nH]ccc4c3n2C2CCC(CC#N)CC2)CCC1
Show InChI InChI=1S/C23H28N6O2/c24-10-6-15-2-4-16(5-3-15)29-19(12-20(30)27-14-23(31)8-1-9-23)28-18-13-26-22-17(21(18)29)7-11-25-22/h7,11,13,15-16,31H,1-6,8-9,12,14H2,(H,25,26)(H,27,30)
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n/an/a 7n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
TYK2 (aa 580-1182)


(Homo sapiens (Human))
BDBM505107
PNG
(US11066406, Ex. 1)
Show SMILES CC(C)(O)CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1
Show InChI InChI=1S/C22H28N6O2/c1-22(2,30)13-26-19(29)11-18-27-17-12-25-21-16(8-10-24-21)20(17)28(18)15-5-3-14(4-6-15)7-9-23/h8,10,12,14-15,30H,3-7,11,13H2,1-2H3,(H,24,25)(H,26,29)
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n/an/a 7.40n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK2 (aa 532-1132)


(Homo sapiens (Human))
BDBM505107
PNG
(US11066406, Ex. 1)
Show SMILES CC(C)(O)CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1
Show InChI InChI=1S/C22H28N6O2/c1-22(2,30)13-26-19(29)11-18-27-17-12-25-21-16(8-10-24-21)20(17)28(18)15-5-3-14(4-6-15)7-9-23/h8,10,12,14-15,30H,3-7,11,13H2,1-2H3,(H,24,25)(H,26,29)
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n/an/a 8.60n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
TYK2 (aa 580-1182)


(Homo sapiens (Human))
BDBM505118
PNG
(US11066406, Ex. 12)
Show SMILES OC1(CNC(=O)Cc2nc3cnc4[nH]ccc4c3n2C2CCC(CC#N)CC2)CC1
Show InChI InChI=1S/C22H26N6O2/c23-9-5-14-1-3-15(4-2-14)28-18(11-19(29)26-13-22(30)7-8-22)27-17-12-25-21-16(20(17)28)6-10-24-21/h6,10,12,14-15,30H,1-5,7-8,11,13H2,(H,24,25)(H,26,29)
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n/an/a 8.70n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
TYK2 (aa 580-1182)


(Homo sapiens (Human))
BDBM505116
PNG
(US11066406, Ex. 10)
Show SMILES O=C(Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)NC12CCC(CC#N)(CC1)C2
Show InChI InChI=1S/C27H31N7O/c28-12-5-18-1-3-19(4-2-18)34-22(32-21-16-31-25-20(24(21)34)6-14-30-25)15-23(35)33-27-9-7-26(17-27,8-10-27)11-13-29/h6,14,16,18-19H,1-5,7-11,15,17H2,(H,30,31)(H,33,35)
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n/an/a 9n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK2 (aa 532-1132)


(Homo sapiens (Human))
BDBM505118
PNG
(US11066406, Ex. 12)
Show SMILES OC1(CNC(=O)Cc2nc3cnc4[nH]ccc4c3n2C2CCC(CC#N)CC2)CC1
Show InChI InChI=1S/C22H26N6O2/c23-9-5-14-1-3-15(4-2-14)28-18(11-19(29)26-13-22(30)7-8-22)27-17-12-25-21-16(20(17)28)6-10-24-21/h6,10,12,14-15,30H,1-5,7-8,11,13H2,(H,24,25)(H,26,29)
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n/an/a 9.40n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
TYK2 (aa 580-1182)


(Homo sapiens (Human))
BDBM505109
PNG
(US11066406, Ex. 3)
Show SMILES O=C(Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)NCC1CC1
Show InChI InChI=1S/C22H26N6O/c23-9-7-14-3-5-16(6-4-14)28-19(11-20(29)25-12-15-1-2-15)27-18-13-26-22-17(21(18)28)8-10-24-22/h8,10,13-16H,1-7,11-12H2,(H,24,26)(H,25,29)
PDB
MMDB

GoogleScholar
UniChem
US Patent
n/an/a 11.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK3 (aa 512-1124)


(Homo sapiens (Human))
BDBM505104
PNG
(US11066406, A)
Show SMILES Cc1nc2ccc3[nH]ccc3c2n1C1CCC(CC1)C#N
Show InChI InChI=1S/C17H18N4/c1-11-20-16-7-6-15-14(8-9-19-15)17(16)21(11)13-4-2-12(10-18)3-5-13/h6-9,12-13,19H,2-5H2,1H3
PDB
MMDB

KEGG

DrugBank
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n/an/a 12.4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK3 (aa 512-1124)


(Homo sapiens (Human))
BDBM505105
PNG
(US11066406, B)
Show SMILES OCc1nc2ccc3[nH]ccc3c2n1C1CCC(CC1)C#N
Show InChI InChI=1S/C17H18N4O/c18-9-11-1-3-12(4-2-11)21-16(10-22)20-15-6-5-14-13(17(15)21)7-8-19-14/h5-8,11-12,19,22H,1-4,10H2
PDB
MMDB

KEGG

DrugBank
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n/an/a 13.4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK3 (aa 512-1124)


(Homo sapiens (Human))
BDBM505111
PNG
(US11066406, Ex. 5)
Show SMILES O=C(Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)NC1CCOCC1
Show InChI InChI=1S/C23H28N6O2/c24-9-5-15-1-3-17(4-2-15)29-20(13-21(30)27-16-7-11-31-12-8-16)28-19-14-26-23-18(22(19)29)6-10-25-23/h6,10,14-17H,1-5,7-8,11-13H2,(H,25,26)(H,27,30)
PDB
MMDB

KEGG

DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 23.1n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK3 (aa 512-1124)


(Homo sapiens (Human))
BDBM505112
PNG
(US11066406, Ex. 6)
Show SMILES O=C(Cc1nc2cnc3[nH]ccc3c2n1C1(CC#N)CCCCC1)NCC1CCOCC1
Show InChI InChI=1S/C24H30N6O2/c25-10-9-24(7-2-1-3-8-24)30-20(14-21(31)27-15-17-5-12-32-13-6-17)29-19-16-28-23-18(22(19)30)4-11-26-23/h4,11,16-17H,1-3,5-9,12-15H2,(H,26,28)(H,27,31)
PDB
MMDB

KEGG

DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 28.2n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK3 (aa 512-1124)


(Homo sapiens (Human))
BDBM505117
PNG
(US11066406, Ex. 11)
Show SMILES O=C(Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)Nc1cc[nH]n1
Show InChI InChI=1S/C21H22N8O/c22-8-5-13-1-3-14(4-2-13)29-18(11-19(30)27-17-7-10-25-28-17)26-16-12-24-21-15(20(16)29)6-9-23-21/h6-7,9-10,12-14H,1-5,11H2,(H,23,24)(H2,25,27,28,30)
PDB
MMDB

KEGG

DrugBank
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n/an/a 30.3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK3 (aa 512-1124)


(Homo sapiens (Human))
BDBM505108
PNG
(US11066406, Ex. 2)
Show SMILES N#CCC1CCC(CC1)n1c(nc2cnc3[nH]ccc3c12)-c1c[nH]cn1
Show InChI InChI=1S/C19H19N7/c20-7-5-12-1-3-13(4-2-12)26-17-14-6-8-22-18(14)23-10-15(17)25-19(26)16-9-21-11-24-16/h6,8-13H,1-5H2,(H,21,24)(H,22,23)
PDB
MMDB

KEGG

DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 33.9n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK3 (aa 512-1124)


(Homo sapiens (Human))
BDBM505106
PNG
(US11066406, C)
Show SMILES C[C@H](O)c1nc2ccc3[nH]ccc3c2n1C1CCC(CC1)C#N
PDB
MMDB

KEGG

DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 49.7n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK3 (aa 512-1124)


(Homo sapiens (Human))
BDBM505114
PNG
(US11066406, Ex. 8)
Show SMILES OC1(CNC(=O)Cc2nc3cnc4[nH]ccc4c3n2C2CCC(CC#N)CC2)CCC1
Show InChI InChI=1S/C23H28N6O2/c24-10-6-15-2-4-16(5-3-15)29-19(12-20(30)27-14-23(31)8-1-9-23)28-18-13-26-22-17(21(18)29)7-11-25-22/h7,11,13,15-16,31H,1-6,8-9,12,14H2,(H,25,26)(H,27,30)
PDB
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KEGG

DrugBank
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n/an/a 75.6n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK3 (aa 512-1124)


(Homo sapiens (Human))
BDBM505115
PNG
(US11066406, Ex. 9)
Show SMILES Cn1cc(NC(=O)Cc2nc3cnc4[nH]ccc4c3n2C2CCC(CC#N)CC2)cn1
Show InChI InChI=1S/C22H24N8O/c1-29-13-15(11-26-29)27-20(31)10-19-28-18-12-25-22-17(7-9-24-22)21(18)30(19)16-4-2-14(3-5-16)6-8-23/h7,9,11-14,16H,2-6,10H2,1H3,(H,24,25)(H,27,31)
PDB
MMDB

KEGG

DrugBank
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n/an/a 79.9n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK3 (aa 512-1124)


(Homo sapiens (Human))
BDBM505109
PNG
(US11066406, Ex. 3)
Show SMILES O=C(Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)NCC1CC1
Show InChI InChI=1S/C22H26N6O/c23-9-7-14-3-5-16(6-4-14)28-19(11-20(29)25-12-15-1-2-15)27-18-13-26-22-17(21(18)28)8-10-24-22/h8,10,13-16H,1-7,11-12H2,(H,24,26)(H,25,29)
PDB
MMDB

KEGG

DrugBank
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US Patent
n/an/a 82.8n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK3 (aa 512-1124)


(Homo sapiens (Human))
BDBM505116
PNG
(US11066406, Ex. 10)
Show SMILES O=C(Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)NC12CCC(CC#N)(CC1)C2
Show InChI InChI=1S/C27H31N7O/c28-12-5-18-1-3-19(4-2-18)34-22(32-21-16-31-25-20(24(21)34)6-14-30-25)15-23(35)33-27-9-7-26(17-27,8-10-27)11-13-29/h6,14,16,18-19H,1-5,7-11,15,17H2,(H,30,31)(H,33,35)
PDB
MMDB

KEGG

DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 87.5n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK3 (aa 512-1124)


(Homo sapiens (Human))
BDBM505107
PNG
(US11066406, Ex. 1)
Show SMILES CC(C)(O)CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1
Show InChI InChI=1S/C22H28N6O2/c1-22(2,30)13-26-19(29)11-18-27-17-12-25-21-16(8-10-24-21)20(17)28(18)15-5-3-14(4-6-15)7-9-23/h8,10,12,14-15,30H,3-7,11,13H2,1-2H3,(H,24,25)(H,26,29)
PDB
MMDB

KEGG

DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 92.2n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK3 (aa 512-1124)


(Homo sapiens (Human))
BDBM505110
PNG
(US11066406, Ex. 4)
Show SMILES O=C(Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)NCCC#N
Show InChI InChI=1S/C21H23N7O/c22-8-1-10-24-19(29)12-18-27-17-13-26-21-16(7-11-25-21)20(17)28(18)15-4-2-14(3-5-15)6-9-23/h7,11,13-15H,1-6,10,12H2,(H,24,29)(H,25,26)
PDB
MMDB

KEGG

DrugBank
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n/an/a 96.2n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK3 (aa 512-1124)


(Homo sapiens (Human))
BDBM505113
PNG
(US11066406, Ex. 7)
Show SMILES CC(C)(CNC(=O)Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)C#N
Show InChI InChI=1S/C23H27N7O/c1-23(2,13-25)14-28-20(31)11-19-29-18-12-27-22-17(8-10-26-22)21(18)30(19)16-5-3-15(4-6-16)7-9-24/h8,10,12,15-16H,3-7,11,14H2,1-2H3,(H,26,27)(H,28,31)
PDB
MMDB

KEGG

DrugBank
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UniChem
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n/an/a 98.4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
JAK3 (aa 512-1124)


(Homo sapiens (Human))
BDBM505118
PNG
(US11066406, Ex. 12)
Show SMILES OC1(CNC(=O)Cc2nc3cnc4[nH]ccc4c3n2C2CCC(CC#N)CC2)CC1
Show InChI InChI=1S/C22H26N6O2/c23-9-5-14-1-3-15(4-2-14)28-18(11-19(29)26-13-22(30)7-8-22)27-17-12-25-21-16(20(17)28)6-10-24-21/h6,10,12,14-15,30H,1-5,7-8,11,13H2,(H,24,25)(H,26,29)
PDB
MMDB

KEGG

DrugBank
GoogleScholar
UniChem
US Patent
n/an/a 101n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Substrate (NH2-KGGEEEEYFELVKK-CO2), internal standard peptide (NH2-SWGAIETDKEYYTVKD-CO2) and product peptide (for standard curve only) (NH2-KGGEEEEY-...


US Patent US11066406 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%