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Patent code US11066413

Compile Data Set for Download or QSAR
Found 60 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505387
PNG
(US11066413, Compound 56)
Show SMILES CN1C(=O)c2c(nc(N)nc2-c2ccc(C)o2)C1=Cc1ccc(F)cc1C(F)(F)F
Show InChI InChI=1S/C20H14F4N4O2/c1-9-3-6-14(30-9)17-15-16(26-19(25)27-17)13(28(2)18(15)29)7-10-4-5-11(21)8-12(10)20(22,23)24/h3-8H,1-2H3,(H2,25,26,27)/b13-7+
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n/an/a 3.40n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505383
PNG
(US11066413, Compound 52)
Show SMILES CN1C(=O)c2c(nc(N)nc2-c2ccc(C)o2)C1=Cc1ccccc1OC(F)(F)F
Show InChI InChI=1S/C20H15F3N4O3/c1-10-7-8-14(29-10)17-15-16(25-19(24)26-17)12(27(2)18(15)28)9-11-5-3-4-6-13(11)30-20(21,22)23/h3-9H,1-2H3,(H2,24,25,26)/b12-9+
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n/an/a 3.60n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505354
PNG
(US11066413, Compound 23)
Show SMILES Nc1nc2C(Cc3ccccc3OC(F)(F)F)OC(=O)c2c(n1)-c1ccco1
Show InChI InChI=1S/C18H12F3N3O4/c19-18(20,21)28-10-5-2-1-4-9(10)8-12-15-13(16(25)27-12)14(23-17(22)24-15)11-6-3-7-26-11/h1-7,12H,8H2,(H2,22,23,24)
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n/an/a 3.90n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505382
PNG
(US11066413, Compound 51)
Show SMILES CN1C(=O)c2c(nc(N)nc2-c2ccc(C)o2)C1=Cc1ccccc1C(F)(F)F
Show InChI InChI=1S/C20H15F3N4O2/c1-10-7-8-14(29-10)17-15-16(25-19(24)26-17)13(27(2)18(15)28)9-11-5-3-4-6-12(11)20(21,22)23/h3-9H,1-2H3,(H2,24,25,26)/b13-9+
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n/an/a 4.70n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505369
PNG
(US11066413, Compound 38)
Show SMILES CN1C(=O)c2c(nc(N)nc2-c2ccco2)C1=Cc1ccccc1F
Show InChI InChI=1S/C18H13FN4O2/c1-23-12(9-10-5-2-3-6-11(10)19)15-14(17(23)24)16(22-18(20)21-15)13-7-4-8-25-13/h2-9H,1H3,(H2,20,21,22)/b12-9+
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n/an/a 6.10n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505381
PNG
(US11066413, Compound 50)
Show SMILES CN1C(=O)c2c(nc(N)nc2-c2ccc(C)o2)C1=Cc1ccccc1F
Show InChI InChI=1S/C19H15FN4O2/c1-10-7-8-14(26-10)17-15-16(22-19(21)23-17)13(24(2)18(15)25)9-11-5-3-4-6-12(11)20/h3-9H,1-2H3,(H2,21,22,23)/b13-9+
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n/an/a 7.30n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505377
PNG
(US11066413, Compound 46)
Show SMILES CN1C(=O)c2c(nc(N)nc2-c2ccco2)C1=Cc1ccc(F)cc1F
Show InChI InChI=1S/C18H12F2N4O2/c1-24-12(7-9-4-5-10(19)8-11(9)20)15-14(17(24)25)16(23-18(21)22-15)13-3-2-6-26-13/h2-8H,1H3,(H2,21,22,23)/b12-7+
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n/an/a 8.70n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505339
PNG
(US11066413, Compound 8)
Show SMILES Nc1nc2C(Cc3ccc(F)cc3F)OC(=O)c2c(n1)-c1ccco1
Show InChI InChI=1S/C17H11F2N3O3/c18-9-4-3-8(10(19)7-9)6-12-15-13(16(23)25-12)14(21-17(20)22-15)11-2-1-5-24-11/h1-5,7,12H,6H2,(H2,20,21,22)
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n/an/a 10.7n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505359
PNG
(US11066413, Compound 28)
Show SMILES Cc1ccc(o1)-c1nc(N)nc2C(Cc3ccccc3C(F)(F)F)OC(=O)c12
Show InChI InChI=1S/C19H14F3N3O3/c1-9-6-7-12(27-9)15-14-16(25-18(23)24-15)13(28-17(14)26)8-10-4-2-3-5-11(10)19(20,21)22/h2-7,13H,8H2,1H3,(H2,23,24,25)
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n/an/a 11.2n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505376
PNG
(US11066413, Compound 45)
Show SMILES CN1C(Cc2ccccc2OC(F)(F)F)c2nc(N)nc(-c3ccco3)c2C1=O
Show InChI InChI=1S/C19H15F3N4O3/c1-26-11(9-10-5-2-3-6-12(10)29-19(20,21)22)15-14(17(26)27)16(25-18(23)24-15)13-7-4-8-28-13/h2-8,11H,9H2,1H3,(H2,23,24,25)
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n/an/a 11.6n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505379
PNG
(US11066413, Compound 48)
Show SMILES CN1C(=O)c2c(nc(N)nc2-c2ccc(C)o2)C1=Cc1ccc(F)cc1F
Show InChI InChI=1S/C19H14F2N4O2/c1-9-3-6-14(27-9)17-15-16(23-19(22)24-17)13(25(2)18(15)26)7-10-4-5-11(20)8-12(10)21/h3-8H,1-2H3,(H2,22,23,24)/b13-7+
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n/an/a 13.2n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505333
PNG
(US11066413, Compound 1 | US11066413, Compound 40)
Show SMILES Nc1nc2C(Cc3ccccc3F)OC(=O)c2c(n1)-c1ccco1
Show InChI InChI=1S/C17H12FN3O3/c18-10-5-2-1-4-9(10)8-12-15-13(16(22)24-12)14(20-17(19)21-15)11-6-3-7-23-11/h1-7,12H,8H2,(H2,19,20,21)
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n/an/a 14.7n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505347
PNG
(US11066413, Compound 16)
Show SMILES Nc1nc2C(Cc3ccccc3C(F)(F)F)OC(=O)c2c(n1)-c1ccco1
Show InChI InChI=1S/C18H12F3N3O3/c19-18(20,21)10-5-2-1-4-9(10)8-12-15-13(16(25)27-12)14(23-17(22)24-15)11-6-3-7-26-11/h1-7,12H,8H2,(H2,22,23,24)
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n/an/a 15.7n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505378
PNG
(US11066413, Compound 47)
Show SMILES CN1C(Cc2ccc(F)cc2F)c2nc(N)nc(-c3ccco3)c2C1=O
Show InChI InChI=1S/C18H14F2N4O2/c1-24-12(7-9-4-5-10(19)8-11(9)20)15-14(17(24)25)16(23-18(21)22-15)13-3-2-6-26-13/h2-6,8,12H,7H2,1H3,(H2,21,22,23)
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n/an/a 16.4n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505356
PNG
(US11066413, Compound 25)
Show SMILES Nc1nc2C(Cc3ccc(F)cc3F)OC(=O)c2c(n1)-c1ccc(Br)o1
Show InChI InChI=1S/C17H10BrF2N3O3/c18-12-4-3-10(25-12)14-13-15(23-17(21)22-14)11(26-16(13)24)5-7-1-2-8(19)6-9(7)20/h1-4,6,11H,5H2,(H2,21,22,23)
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n/an/a 18.6n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505363
PNG
(US11066413, Compound 32)
Show SMILES Cc1ccc(o1)-c1nc(N)nc2C(Cc3ccc(F)cc3C(F)(F)F)OC(=O)c12
Show InChI InChI=1S/C19H13F4N3O3/c1-8-2-5-12(28-8)15-14-16(26-18(24)25-15)13(29-17(14)27)6-9-3-4-10(20)7-11(9)19(21,22)23/h2-5,7,13H,6H2,1H3,(H2,24,25,26)
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n/an/a 19.9n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505389
PNG
(US11066413, Compound 58)
Show SMILES CN1C(Cc2cc[n+]([O-])cc2)c2nc(N)nc(-c3ccc(C)o3)c2C1=O
Show InChI InChI=1S/C18H17N5O3/c1-10-3-4-13(26-10)16-14-15(20-18(19)21-16)12(22(2)17(14)24)9-11-5-7-23(25)8-6-11/h3-8,12H,9H2,1-2H3,(H2,19,20,21)
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n/an/a 21n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505358
PNG
(US11066413, Compound 27)
Show SMILES Cc1ccc(o1)-c1nc(N)nc2C(Cc3ccccc3F)OC(=O)c12
Show InChI InChI=1S/C18H14FN3O3/c1-9-6-7-12(24-9)15-14-16(22-18(20)21-15)13(25-17(14)23)8-10-4-2-3-5-11(10)19/h2-7,13H,8H2,1H3,(H2,20,21,22)
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n/an/a 21n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505367
PNG
(US11066413, Compound 36)
Show SMILES Cc1ccc(o1)-c1nc(N)nc2n(Cc3ccccc3OC(F)(F)F)c(=O)n(C)c12
Show InChI InChI=1S/C19H16F3N5O3/c1-10-7-8-13(29-10)14-15-16(25-17(23)24-14)27(18(28)26(15)2)9-11-5-3-4-6-12(11)30-19(20,21)22/h3-8H,9H2,1-2H3,(H2,23,24,25)
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n/an/a 28.1n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505348
PNG
(US11066413, Compound 17)
Show SMILES Nc1nc2C(Cc3c(F)cccc3Cl)OC(=O)c2c(n1)-c1ccco1
Show InChI InChI=1S/C17H11ClFN3O3/c18-9-3-1-4-10(19)8(9)7-12-15-13(16(23)25-12)14(21-17(20)22-15)11-5-2-6-24-11/h1-6,12H,7H2,(H2,20,21,22)
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n/an/a 29.2n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505386
PNG
(US11066413, Compound 55)
Show SMILES CN1C(Cc2ccccc2F)c2nc(N)nc(-c3ccc(C)o3)c2C1=O
Show InChI InChI=1S/C19H17FN4O2/c1-10-7-8-14(26-10)17-15-16(22-19(21)23-17)13(24(2)18(15)25)9-11-5-3-4-6-12(11)20/h3-8,13H,9H2,1-2H3,(H2,21,22,23)
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n/an/a 29.3n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505366
PNG
(US11066413, Compound 35)
Show SMILES Cn1c2c(nc(N)nc2n(Cc2ccc(F)cc2F)c1=O)-c1ccco1
Show InChI InChI=1S/C17H13F2N5O2/c1-23-14-13(12-3-2-6-26-12)21-16(20)22-15(14)24(17(23)25)8-9-4-5-10(18)7-11(9)19/h2-7H,8H2,1H3,(H2,20,21,22)
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n/an/a 30.1n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505350
PNG
(US11066413, Compound 19)
Show SMILES Cc1ccccc1CC1OC(=O)c2c1nc(N)nc2-c1ccco1
Show InChI InChI=1S/C18H15N3O3/c1-10-5-2-3-6-11(10)9-13-16-14(17(22)24-13)15(20-18(19)21-16)12-7-4-8-23-12/h2-8,13H,9H2,1H3,(H2,19,20,21)
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n/an/a 31.1n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505380
PNG
(US11066413, Compound 49)
Show SMILES CN1C(Cc2ccc(F)cc2F)c2nc(N)nc(-c3ccc(C)o3)c2C1=O
Show InChI InChI=1S/C19H16F2N4O2/c1-9-3-6-14(27-9)17-15-16(23-19(22)24-17)13(25(2)18(15)26)7-10-4-5-11(20)8-12(10)21/h3-6,8,13H,7H2,1-2H3,(H2,22,23,24)
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n/an/a 32.1n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505342
PNG
(US11066413, Compound 11)
Show SMILES Nc1nc2C(Cc3ccccc3Cl)OC(=O)c2c(n1)-c1ccco1
Show InChI InChI=1S/C17H12ClN3O3/c18-10-5-2-1-4-9(10)8-12-15-13(16(22)24-12)14(20-17(19)21-15)11-6-3-7-23-11/h1-7,12H,8H2,(H2,19,20,21)
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n/an/a 32.1n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505357
PNG
(US11066413, Compound 26 | US11066413, Compound 42)
Show SMILES Cc1ccc(o1)-c1nc(N)nc2C(Cc3ccc(F)cc3F)OC(=O)c12
Show InChI InChI=1S/C18H13F2N3O3/c1-8-2-5-12(25-8)15-14-16(23-18(21)22-15)13(26-17(14)24)6-9-3-4-10(19)7-11(9)20/h2-5,7,13H,6H2,1H3,(H2,21,22,23)
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n/an/a 32.1n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505385
PNG
(US11066413, Compound 54)
Show SMILES CN1C(Cc2ccccc2C(F)(F)F)c2nc(N)nc(-c3ccc(C)o3)c2C1=O
Show InChI InChI=1S/C20H17F3N4O2/c1-10-7-8-14(29-10)17-15-16(25-19(24)26-17)13(27(2)18(15)28)9-11-5-3-4-6-12(11)20(21,22)23/h3-8,13H,9H2,1-2H3,(H2,24,25,26)
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n/an/a 34.7n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505362
PNG
(US11066413, Compound 31)
Show SMILES Cc1ccc(o1)-c1nc(N)nc2C(Cc3c(F)cccc3Cl)OC(=O)c12
Show InChI InChI=1S/C18H13ClFN3O3/c1-8-5-6-12(25-8)15-14-16(23-18(21)22-15)13(26-17(14)24)7-9-10(19)3-2-4-11(9)20/h2-6,13H,7H2,1H3,(H2,21,22,23)
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n/an/a 38.4n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505365
PNG
(US11066413, Compound 34)
Show SMILES Nc1nc(-c2ccco2)c2nc(=O)n(Cc3ccc(F)cc3F)c2n1
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n/an/a 39.2n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505334
PNG
(US11066413, Compound 2)
Show SMILES Nc1nc2C(Cc3ccc(Cl)cc3F)OC(=O)c2c(n1)-c1ccco1
Show InChI InChI=1S/C17H11ClFN3O3/c18-9-4-3-8(10(19)7-9)6-12-15-13(16(23)25-12)14(21-17(20)22-15)11-2-1-5-24-11/h1-5,7,12H,6H2,(H2,20,21,22)
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n/an/a 39.3n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505337
PNG
(US11066413, Compound 5)
Show SMILES Nc1nc2C(Cc3ccccc3)OC(=O)c2c(n1)-c1ccco1
Show InChI InChI=1S/C17H13N3O3/c18-17-19-14(11-7-4-8-22-11)13-15(20-17)12(23-16(13)21)9-10-5-2-1-3-6-10/h1-8,12H,9H2,(H2,18,19,20)
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n/an/a 40n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505372
PNG
(US11066413, Compound 41)
Show SMILES Cn1c2c(nc(N)nc2n(Cc2ccccc2F)c1=O)-c1ccco1
Show InChI InChI=1S/C17H14FN5O2/c1-22-14-13(12-7-4-8-25-12)20-16(19)21-15(14)23(17(22)24)9-10-5-2-3-6-11(10)18/h2-8H,9H2,1H3,(H2,19,20,21)
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n/an/a 43.5n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505353
PNG
(US11066413, Compound 22)
Show SMILES Nc1nc2C(Cc3c(F)cccc3F)OC(=O)c2c(n1)-c1ccco1
Show InChI InChI=1S/C17H11F2N3O3/c18-9-3-1-4-10(19)8(9)7-12-15-13(16(23)25-12)14(21-17(20)22-15)11-5-2-6-24-11/h1-6,12H,7H2,(H2,20,21,22)
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n/an/a 47.3n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505384
PNG
(US11066413, Compound 53)
Show SMILES CN1C(Cc2ccccc2OC(F)(F)F)c2nc(N)nc(-c3ccc(C)o3)c2C1=O
Show InChI InChI=1S/C20H17F3N4O3/c1-10-7-8-14(29-10)17-15-16(25-19(24)26-17)12(27(2)18(15)28)9-11-5-3-4-6-13(11)30-20(21,22)23/h3-8,12H,9H2,1-2H3,(H2,24,25,26)
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n/an/a 56.2n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505375
PNG
(US11066413, Compound 44)
Show SMILES CN1C(Cc2ccccc2F)c2nc(N)nc(-c3ccco3)c2C1=O
Show InChI InChI=1S/C18H15FN4O2/c1-23-12(9-10-5-2-3-6-11(10)19)15-14(17(23)24)16(22-18(20)21-15)13-7-4-8-25-13/h2-8,12H,9H2,1H3,(H2,20,21,22)
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n/an/a 64.6n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505368
PNG
(US11066413, Compound 37)
Show SMILES Nc1nc2C(Cc3ccccc3OC(F)(F)F)OC(=O)c2c(n1)-c1ccc(Br)o1
Show InChI InChI=1S/C18H11BrF3N3O4/c19-12-6-5-10(27-12)14-13-15(25-17(23)24-14)11(28-16(13)26)7-8-3-1-2-4-9(8)29-18(20,21)22/h1-6,11H,7H2,(H2,23,24,25)
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n/an/a 67.4n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505349
PNG
(US11066413, Compound 18)
Show SMILES Nc1nc2C(Cc3cccc(Cl)c3F)OC(=O)c2c(n1)-c1ccco1
Show InChI InChI=1S/C17H11ClFN3O3/c18-9-4-1-3-8(13(9)19)7-11-15-12(16(23)25-11)14(21-17(20)22-15)10-5-2-6-24-10/h1-6,11H,7H2,(H2,20,21,22)
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n/an/a 73.7n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505333
PNG
(US11066413, Compound 1 | US11066413, Compound 40)
Show SMILES Nc1nc2C(Cc3ccccc3F)OC(=O)c2c(n1)-c1ccco1
Show InChI InChI=1S/C17H12FN3O3/c18-10-5-2-1-4-9(10)8-12-15-13(16(22)24-12)14(20-17(19)21-15)11-6-3-7-23-11/h1-7,12H,8H2,(H2,19,20,21)
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n/an/a 79n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505357
PNG
(US11066413, Compound 26 | US11066413, Compound 42)
Show SMILES Cc1ccc(o1)-c1nc(N)nc2C(Cc3ccc(F)cc3F)OC(=O)c12
Show InChI InChI=1S/C18H13F2N3O3/c1-8-2-5-12(25-8)15-14-16(23-18(21)22-15)13(26-17(14)24)6-9-3-4-10(19)7-11(9)20/h2-5,7,13H,6H2,1H3,(H2,21,22,23)
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n/an/a 87.4n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505361
PNG
(US11066413, Compound 30)
Show SMILES Cc1ccc(o1)-c1nc(N)nc2C(Cc3cc(Cl)ccc3F)OC(=O)c12
Show InChI InChI=1S/C18H13ClFN3O3/c1-8-2-5-12(25-8)15-14-16(23-18(21)22-15)13(26-17(14)24)7-9-6-10(19)3-4-11(9)20/h2-6,13H,7H2,1H3,(H2,21,22,23)
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n/an/a 94n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505343
PNG
(US11066413, Compound 12)
Show SMILES Nc1nc2C(Cc3ccc(Cl)c(F)c3)OC(=O)c2c(n1)-c1ccco1
Show InChI InChI=1S/C17H11ClFN3O3/c18-9-4-3-8(6-10(9)19)7-12-15-13(16(23)25-12)14(21-17(20)22-15)11-2-1-5-24-11/h1-6,12H,7H2,(H2,20,21,22)
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n/an/a 99.8n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505352
PNG
(US11066413, Compound 21)
Show SMILES Nc1nc2C(Cc3ccc(OC(F)(F)F)cc3)OC(=O)c2c(n1)-c1ccco1
Show InChI InChI=1S/C18H12F3N3O4/c19-18(20,21)28-10-5-3-9(4-6-10)8-12-15-13(16(25)27-12)14(23-17(22)24-15)11-2-1-7-26-11/h1-7,12H,8H2,(H2,22,23,24)
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n/an/a 106n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505333
PNG
(US11066413, Compound 1 | US11066413, Compound 40)
Show SMILES Nc1nc2C(Cc3ccccc3F)OC(=O)c2c(n1)-c1ccco1
Show InChI InChI=1S/C17H12FN3O3/c18-10-5-2-1-4-9(10)8-12-15-13(16(22)24-12)14(20-17(19)21-15)11-6-3-7-23-11/h1-7,12H,8H2,(H2,19,20,21)
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n/an/a 106n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505341
PNG
(US11066413, Compound 10)
Show SMILES Nc1nc2C(Cc3ccc(F)cc3Cl)OC(=O)c2c(n1)-c1ccco1
Show InChI InChI=1S/C17H11ClFN3O3/c18-10-7-9(19)4-3-8(10)6-12-15-13(16(23)25-12)14(21-17(20)22-15)11-2-1-5-24-11/h1-5,7,12H,6H2,(H2,20,21,22)
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n/an/a 114n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505370
PNG
(US11066413, Compound 39)
Show SMILES Cc1ccc(o1)-c1nc(N)nc2C(Cc3ccccc3OC(F)F)OC(=O)c12
Show InChI InChI=1S/C19H15F2N3O4/c1-9-6-7-12(26-9)15-14-16(24-19(22)23-15)13(27-17(14)25)8-10-4-2-3-5-11(10)28-18(20)21/h2-7,13,18H,8H2,1H3,(H2,22,23,24)
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n/an/a 128n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505344
PNG
(US11066413, Compound 13)
Show SMILES CS(=O)(=O)c1ccc(CC2OC(=O)c3c2nc(N)nc3-c2ccco2)cc1
Show InChI InChI=1S/C18H15N3O5S/c1-27(23,24)11-6-4-10(5-7-11)9-13-16-14(17(22)26-13)15(20-18(19)21-16)12-3-2-8-25-12/h2-8,13H,9H2,1H3,(H2,19,20,21)
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n/an/a 152n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505388
PNG
(US11066413, Compound 57)
Show SMILES CN1C(Cc2ccc(F)cc2C(F)(F)F)c2nc(N)nc(-c3ccc(C)o3)c2C1=O
Show InChI InChI=1S/C20H16F4N4O2/c1-9-3-6-14(30-9)17-15-16(26-19(25)27-17)13(28(2)18(15)29)7-10-4-5-11(21)8-12(10)20(22,23)24/h3-6,8,13H,7H2,1-2H3,(H2,25,26,27)
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n/an/a 152n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505338
PNG
(US11066413, Compound 6)
Show SMILES Nc1nc2[C@@H](Cc3ccccc3)OCc2c(n1)-c1ccco1
Show InChI InChI=1S/C17H15N3O2/c18-17-19-15(13-7-4-8-21-13)12-10-22-14(16(12)20-17)9-11-5-2-1-3-6-11/h1-8,14H,9-10H2,(H2,18,19,20)/t14-/m1/s1
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n/an/a 157n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505335
PNG
(US11066413, Compound 3)
Show SMILES Nc1nc2C(Cc3ccc(C#N)c(F)c3)OC(=O)c2c(n1)-c1ccco1
Show InChI InChI=1S/C18H11FN4O3/c19-11-6-9(3-4-10(11)8-20)7-13-16-14(17(24)26-13)15(22-18(21)23-16)12-2-1-5-25-12/h1-6,13H,7H2,(H2,21,22,23)
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n/an/a 159n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505391
PNG
(US11066413, Compound 60)
Show SMILES Cc1ccc(o1)-c1nc(N)nc2n(Cc3ccccc3C(F)(F)F)c(=O)[nH]c12
Show InChI InChI=1S/C18H14F3N5O2/c1-9-6-7-12(28-9)13-14-15(25-16(22)23-13)26(17(27)24-14)8-10-4-2-3-5-11(10)18(19,20)21/h2-7H,8H2,1H3,(H,24,27)(H2,22,23,25)
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n/an/a 177n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505390
PNG
(US11066413, Compound 59)
Show SMILES CN1C(Cc2ccncc2)c2nc(N)nc(-c3ccc(C)o3)c2C1=O
Show InChI InChI=1S/C18H17N5O2/c1-10-3-4-13(25-10)16-14-15(21-18(19)22-16)12(23(2)17(14)24)9-11-5-7-20-8-6-11/h3-8,12H,9H2,1-2H3,(H2,19,21,22)
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n/an/a 179n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505392
PNG
(US11066413, Compound 61)
Show SMILES Cc1ccc(o1)-c1nc(N)nc2n(Cc3ccc(C)cc3C(F)(F)F)c(=O)[nH]c12
Show InChI InChI=1S/C19H16F3N5O2/c1-9-3-5-11(12(7-9)19(20,21)22)8-27-16-15(25-18(27)28)14(24-17(23)26-16)13-6-4-10(2)29-13/h3-7H,8H2,1-2H3,(H,25,28)(H2,23,24,26)
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n/an/a 213n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505345
PNG
(US11066413, Compound 14)
Show SMILES NC(=O)c1ccc(CC2OC(=O)c3c2nc(N)nc3-c2ccco2)cc1
Show InChI InChI=1S/C18H14N4O4/c19-16(23)10-5-3-9(4-6-10)8-12-15-13(17(24)26-12)14(21-18(20)22-15)11-2-1-7-25-11/h1-7,12H,8H2,(H2,19,23)(H2,20,21,22)
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n/an/a 218n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505336
PNG
(US11066413, Compound 4)
Show SMILES Nc1nc2C(Cc3ccc(cc3)C#N)OC(=O)c2c(n1)-c1ccco1
Show InChI InChI=1S/C18H12N4O3/c19-9-11-5-3-10(4-6-11)8-13-16-14(17(23)25-13)15(21-18(20)22-16)12-2-1-7-24-12/h1-7,13H,8H2,(H2,20,21,22)
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n/an/a 249n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505360
PNG
(US11066413, Compound 29)
Show SMILES Cc1ccc(o1)-c1nc(N)nc2C(Cc3cc(F)ccc3F)OC(=O)c12
Show InChI InChI=1S/C18H13F2N3O3/c1-8-2-5-12(25-8)15-14-16(23-18(21)22-15)13(26-17(14)24)7-9-6-10(19)3-4-11(9)20/h2-6,13H,7H2,1H3,(H2,21,22,23)
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n/an/a 252n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505346
PNG
(US11066413, Compound 15)
Show SMILES Nc1nc2C(Cc3ccc(cc3)C(F)(F)F)OC(=O)c2c(n1)-c1ccco1
Show InChI InChI=1S/C18H12F3N3O3/c19-18(20,21)10-5-3-9(4-6-10)8-12-15-13(16(25)27-12)14(23-17(22)24-15)11-2-1-7-26-11/h1-7,12H,8H2,(H2,22,23,24)
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n/an/a 274n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505364
PNG
(US11066413, Compound 33)
Show SMILES Nc1nc2[C@H](Cc3ccccc3)OCc2c(n1)-c1ccco1
Show InChI InChI=1S/C17H15N3O2/c18-17-19-15(13-7-4-8-21-13)12-10-22-14(16(12)20-17)9-11-5-2-1-3-6-11/h1-8,14H,9-10H2,(H2,18,19,20)/t14-/m0/s1
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n/an/a 275n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505351
PNG
(US11066413, Compound 20)
Show SMILES Nc1nc2C(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)OC(=O)c2c(n1)-c1ccco1
Show InChI InChI=1S/C19H11F6N3O3/c20-18(21,22)9-4-8(5-10(7-9)19(23,24)25)6-12-15-13(16(29)31-12)14(27-17(26)28-15)11-2-1-3-30-11/h1-5,7,12H,6H2,(H2,26,27,28)
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n/an/a 299n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505355
PNG
(US11066413, Compound 24)
Show SMILES Nc1nc2C(Cc3ccccc3)OC(=O)c2c(n1)-c1ccccn1
Show InChI InChI=1S/C18H14N4O2/c19-18-21-15(12-8-4-5-9-20-12)14-16(22-18)13(24-17(14)23)10-11-6-2-1-3-7-11/h1-9,13H,10H2,(H2,19,21,22)
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n/an/a 918n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM505374
PNG
(US11066413, Compound 43)
Show SMILES Cc1ccc(o1)-c1nc(N)nc2c1C(=O)OC2(C)Cc1ccccc1F
Show InChI InChI=1S/C19H16FN3O3/c1-10-7-8-13(25-10)15-14-16(23-18(21)22-15)19(2,26-17(14)24)9-11-5-3-4-6-12(11)20/h3-8H,9H2,1-2H3,(H2,21,22,23)
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n/an/a 992n/an/an/an/an/an/a



GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
1. Preparation of the reagents1) Detection buffer: 50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA, 1 μg/mL Adenosine Deaminase, and stored at 4 ...


US Patent US11066413 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%