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Found 39 Enz. Inhib. hit(s) with all data for entry = 10030
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509527(US11072619, Example 11)
Affinity DataIC50:  0.0300nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509527(US11072619, Example 11)
Affinity DataIC50:  0.0500nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509520(US11072619, Example 6)
Affinity DataIC50:  0.160nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509521(US11072619, Example 7)
Affinity DataIC50:  0.190nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509529(US11072619, Example 13)
Affinity DataIC50:  0.200nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509528(US11072619, Example 12)
Affinity DataIC50:  0.290nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509520(US11072619, Example 6)
Affinity DataIC50:  0.380nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509528(US11072619, Example 12)
Affinity DataIC50:  0.510nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509529(US11072619, Example 13)
Affinity DataIC50:  0.510nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509526(US11072619, Example 10)
Affinity DataIC50:  0.600nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509521(US11072619, Example 7)
Affinity DataIC50:  0.75nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509527(US11072619, Example 11)
Affinity DataIC50:  1.18nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509515((R)-7-((1-(6-Cyanopyridazin-3-yl)-3,3-dimethylpipe...)
Affinity DataIC50:  1.20nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509517((R)-7-((1-(6-Cyanopyridazin-3-yl)-3,3-dimethylpipe...)
Affinity DataIC50:  1.58nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509519(US11072619, Example 5)
Affinity DataIC50:  1.80nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509515((R)-7-((1-(6-Cyanopyridazin-3-yl)-3,3-dimethylpipe...)
Affinity DataIC50:  1.80nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509522(US11072619, Example 8)
Affinity DataIC50:  2.24nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509526(US11072619, Example 10)
Affinity DataIC50:  2.37nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509518(US11072619, Example 4)
Affinity DataIC50:  2.67nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509518(US11072619, Example 4)
Affinity DataIC50:  2.67nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509529(US11072619, Example 13)
Affinity DataIC50:  2.82nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509520(US11072619, Example 6)
Affinity DataIC50:  2.98nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509521(US11072619, Example 7)
Affinity DataIC50:  3.40nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509516(US11072619, Example 2)
Affinity DataIC50:  3.74nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509516(US11072619, Example 2)
Affinity DataIC50:  3.77nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509517((R)-7-((1-(6-Cyanopyridazin-3-yl)-3,3-dimethylpipe...)
Affinity DataIC50:  4.47nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509528(US11072619, Example 12)
Affinity DataIC50:  5.05nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509519(US11072619, Example 5)
Affinity DataIC50:  8.08nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509522(US11072619, Example 8)
Affinity DataIC50:  8.54nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509526(US11072619, Example 10)
Affinity DataIC50:  12.8nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509525(US11072619, Example 9)
Affinity DataIC50:  18.8nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509515((R)-7-((1-(6-Cyanopyridazin-3-yl)-3,3-dimethylpipe...)
Affinity DataIC50:  19nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509522(US11072619, Example 8)
Affinity DataIC50:  26.8nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509518(US11072619, Example 4)
Affinity DataIC50:  27.7nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509517((R)-7-((1-(6-Cyanopyridazin-3-yl)-3,3-dimethylpipe...)
Affinity DataIC50:  31.1nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509519(US11072619, Example 5)
Affinity DataIC50:  34.4nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509525(US11072619, Example 9)
Affinity DataIC50:  47.5nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509516(US11072619, Example 2)
Affinity DataIC50:  59.3nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Celon Pharma

US Patent
LigandPNGBDBM509525(US11072619, Example 9)
Affinity DataIC50:  89.6nMAssay Description:Tested compounds were dissolved in 100% DMSO, and obtained stock solutions were serially diluted in the reaction buffer (50 mM Tris pH 7.5, 10 mM MgC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent